                         SEQUENCE LISTING

<110>  Ramot at Tel-Aviv University Ltd.
       Tel Hashomer Medical Research Infrastructure and Services 
       Ltd.
 
<120>  METHODS OF TREATING NON-INFECTIOUS INFLAMMATORY DISORDERS

<130>  2738029

<150>  US 62/884,184
<151>  2019-08-08

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
    50                  55                  60                  


Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
65                  70                  75                  80  


Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His 
                85                  90                  95      


Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp 
            100                 105                 110         


Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu 
        115                 120                 125             


Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu 
    130                 135                 140                 


Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly 
145                 150                 155                 160 


Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg 
                165                 170                 175     


Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His 
            180                 185                 190         


Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala 
        195                 200                 205             


Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser 
    210                 215                 220                 


Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His Ser His 
225                 230                 235                 240 


Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu 
                245                 250                 255     


His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser Arg Glu 
            260                 265                 270         


Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val Val Asp 
        275                 280                 285             


Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile Ser His 
    290                 295                 300                 


Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
305                 310                 


<210>  2
<211>  1561
<212>  DNA
<213>  Homo sapiens

<400>  2
agcagcagga ggaggcagag cacagcatcg tcgggaccag actcgtctca ggccagttgc       60

agccttctca gccaaacgcc gaccaaggaa aactcactac catgagaatt gcagtgattt      120

gcttttgcct cctaggcatc acctgtgcca taccagttaa acaggctgat tctggaagtt      180

ctgaggaaaa gcagctttac aacaaatacc cagatgctgt ggccacatgg ctaaaccctg      240

acccatctca gaagcagaat ctcctagccc cacagaatgc tgtgtcctct gaagaaacca      300

atgactttaa acaagagacc cttccaagta agtccaacga aagccatgac cacatggatg      360

atatggatga tgaagatgat gatgaccatg tggacagcca ggactccatt gactcgaacg      420

actctgatga tgtagatgac actgatgatt ctcaccagtc tgatgagtct caccattctg      480

atgaatctga tgaactggtc actgattttc ccacggacct gccagcaacc gaagttttca      540

ctccagttgt ccccacagta gacacatatg atggccgagg tgatagtgtg gtttatggac      600

tgaggtcaaa atctaagaag tttcgcagac ctgacatcca gtaccctgat gctacagacg      660

aggacatcac ctcacacatg gaaagcgagg agttgaatgg tgcatacaag gccatccccg      720

ttgcccagga cctgaacgcg ccttctgatt gggacagccg tgggaaggac agttatgaaa      780

cgagtcagct ggatgaccag agtgctgaaa cccacagcca caagcagtcc agattatata      840

agcggaaagc caatgatgag agcaatgagc attccgatgt gattgatagt caggaacttt      900

ccaaagtcag ccgtgaattc cacagccatg aatttcacag ccatgaagat atgctggttg      960

tagaccccaa aagtaaggaa gaagataaac acctgaaatt tcgtatttct catgaattag     1020

atagtgcatc ttctgaggtc aattaaaagg agaaaaaata caatttctca ctttgcattt     1080

agtcaaaaga aaaaatgctt tatagcaaaa tgaaagagaa catgaaatgc ttctttctca     1140

gtttattggt tgaatgtgta tctatttgag tctggaaata actaatgtgt ttgataatta     1200

gtttagtttg tggcttcatg gaaactccct gtaaactaaa agcttcaggg ttatgtctat     1260

gttcattcta tagaagaaat gcaaactatc actgtatttt aatatttgtt attctctcat     1320

gaatagaaat ttatgtagaa gcaaacaaaa tacttttacc cacttaaaaa gagaatataa     1380

cattttatgt cactataatc ttttgttttt taagttagtg tatattttgt tgtgattatc     1440

tttttgtggt gtgaataaat cttttatctt gaatgtaata agaatttggt ggtgtcaatt     1500

gcttatttgt tttcccacgg ttgtccagca attaataaaa cataaccttt tttactgcct     1560

a                                                                     1561


<210>  3
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Thr Leu Pro Ser Lys Ser 
    50                  55                  60                  


Asn Glu Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp 
65                  70                  75                  80  


Asp His Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp 
                85                  90                  95      


Val Asp Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser 
            100                 105                 110         


Asp Glu Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala 
        115                 120                 125             


Thr Glu Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly 
    130                 135                 140                 


Arg Gly Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe 
145                 150                 155                 160 


Arg Arg Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr 
                165                 170                 175     


Ser His Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro 
            180                 185                 190         


Val Ala Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys 
        195                 200                 205             


Asp Ser Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His 
    210                 215                 220                 


Ser His Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser 
225                 230                 235                 240 


Asn Glu His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser 
                245                 250                 255     


Arg Glu Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val 
            260                 265                 270         


Val Asp Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile 
        275                 280                 285             


Ser His Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
    290                 295                 300 


<210>  4
<211>  1616
<212>  DNA
<213>  Homo sapiens

<400>  4
ctccctgtgt tggtggagga tgtctgcagc agcatttaaa ttctgggagg gcttggttgt       60

cagcagcagc aggaggaggc agagcacagc atcgtcggga ccagactcgt ctcaggccag      120

ttgcagcctt ctcagccaaa cgccgaccaa ggaaaactca ctaccatgag aattgcagtg      180

atttgctttt gcctcctagg catcacctgt gccataccag ttaaacaggc tgattctgga      240

agttctgagg aaaagcagct ttacaacaaa tacccagatg ctgtggccac atggctaaac      300

cctgacccat ctcagaagca gaatctccta gccccacaga cccttccaag taagtccaac      360

gaaagccatg accacatgga tgatatggat gatgaagatg atgatgacca tgtggacagc      420

caggactcca ttgactcgaa cgactctgat gatgtagatg acactgatga ttctcaccag      480

tctgatgagt ctcaccattc tgatgaatct gatgaactgg tcactgattt tcccacggac      540

ctgccagcaa ccgaagtttt cactccagtt gtccccacag tagacacata tgatggccga      600

ggtgatagtg tggtttatgg actgaggtca aaatctaaga agtttcgcag acctgacatc      660

cagtaccctg atgctacaga cgaggacatc acctcacaca tggaaagcga ggagttgaat      720

ggtgcataca aggccatccc cgttgcccag gacctgaacg cgccttctga ttgggacagc      780

cgtgggaagg acagttatga aacgagtcag ctggatgacc agagtgctga aacccacagc      840

cacaagcagt ccagattata taagcggaaa gccaatgatg agagcaatga gcattccgat      900

gtgattgata gtcaggaact ttccaaagtc agccgtgaat tccacagcca tgaatttcac      960

agccatgaag atatgctggt tgtagacccc aaaagtaagg aagaagataa acacctgaaa     1020

tttcgtattt ctcatgaatt agatagtgca tcttctgagg tcaattaaaa ggagaaaaaa     1080

tacaatttct cactttgcat ttagtcaaaa gaaaaaatgc tttatagcaa aatgaaagag     1140

aacatgaaat gcttctttct cagtttattg gttgaatgtg tatctatttg agtctggaaa     1200

taactaatgt gtttgataat tagtttagtt tgtggcttca tggaaactcc ctgtaaacta     1260

aaagcttcag ggttatgtct atgttcattc tatagaagaa atgcaaacta tcactgtatt     1320

ttaatatttg ttattctctc atgaatagaa atttatgtag aagcaaacaa aatactttta     1380

cccacttaaa aagagaatat aacattttat gtcactataa tcttttgttt tttaagttag     1440

tgtatatttt gttgtgatta tctttttgtg gtgtgaataa atcttttatc ttgaatgtaa     1500

taagaatttg gtggtgtcaa ttgcttattt gttttcccac ggttgtccag caattaataa     1560

aacataacct tttttactgc ctaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa         1616


<210>  5
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Asn 
            20                  25                  30          


Ala Val Ser Ser Glu Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro 
        35                  40                  45              


Ser Lys Ser Asn Glu Ser His Asp His Met Asp Asp Met Asp Asp Glu 
    50                  55                  60                  


Asp Asp Asp Asp His Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp 
65                  70                  75                  80  


Ser Asp Asp Val Asp Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser 
                85                  90                  95      


His His Ser Asp Glu Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp 
            100                 105                 110         


Leu Pro Ala Thr Glu Val Phe Thr Pro Val Val Pro Thr Val Asp Thr 
        115                 120                 125             


Tyr Asp Gly Arg Gly Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser 
    130                 135                 140                 


Lys Lys Phe Arg Arg Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu 
145                 150                 155                 160 


Asp Ile Thr Ser His Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys 
                165                 170                 175     


Ala Ile Pro Val Ala Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser 
            180                 185                 190         


Arg Gly Lys Asp Ser Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala 
        195                 200                 205             


Glu Thr His Ser His Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn 
    210                 215                 220                 


Asp Glu Ser Asn Glu His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser 
225                 230                 235                 240 


Lys Val Ser Arg Glu Phe His Ser His Glu Phe His Ser His Glu Asp 
                245                 250                 255     


Met Leu Val Val Asp Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys 
            260                 265                 270         


Phe Arg Ile Ser His Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
        275                 280                 285         


<210>  6
<211>  1560
<212>  DNA
<213>  Homo sapiens

<400>  6
ctccctgtgt tggtggagga tgtctgcagc agcatttaaa ttctgggagg gcttggttgt       60

cagcagcagc aggaggaggc agagcacagc atcgtcggga ccagactcgt ctcaggccag      120

ttgcagcctt ctcagccaaa cgccgaccaa ggaaaactca ctaccatgag aattgcagtg      180

atttgctttt gcctcctagg catcacctgt gccataccag ttaaacaggc tgattctgga      240

agttctgagg aaaagcagaa tgctgtgtcc tctgaagaaa ccaatgactt taaacaagag      300

acccttccaa gtaagtccaa cgaaagccat gaccacatgg atgatatgga tgatgaagat      360

gatgatgacc atgtggacag ccaggactcc attgactcga acgactctga tgatgtagat      420

gacactgatg attctcacca gtctgatgag tctcaccatt ctgatgaatc tgatgaactg      480

gtcactgatt ttcccacgga cctgccagca accgaagttt tcactccagt tgtccccaca      540

gtagacacat atgatggccg aggtgatagt gtggtttatg gactgaggtc aaaatctaag      600

aagtttcgca gacctgacat ccagtaccct gatgctacag acgaggacat cacctcacac      660

atggaaagcg aggagttgaa tggtgcatac aaggccatcc ccgttgccca ggacctgaac      720

gcgccttctg attgggacag ccgtgggaag gacagttatg aaacgagtca gctggatgac      780

cagagtgctg aaacccacag ccacaagcag tccagattat ataagcggaa agccaatgat      840

gagagcaatg agcattccga tgtgattgat agtcaggaac tttccaaagt cagccgtgaa      900

ttccacagcc atgaatttca cagccatgaa gatatgctgg ttgtagaccc caaaagtaag      960

gaagaagata aacacctgaa atttcgtatt tctcatgaat tagatagtgc atcttctgag     1020

gtcaattaaa aggagaaaaa atacaatttc tcactttgca tttagtcaaa agaaaaaatg     1080

ctttatagca aaatgaaaga gaacatgaaa tgcttctttc tcagtttatt ggttgaatgt     1140

gtatctattt gagtctggaa ataactaatg tgtttgataa ttagtttagt ttgtggcttc     1200

atggaaactc cctgtaaact aaaagcttca gggttatgtc tatgttcatt ctatagaaga     1260

aatgcaaact atcactgtat tttaatattt gttattctct catgaataga aatttatgta     1320

gaagcaaaca aaatactttt acccacttaa aaagagaata taacatttta tgtcactata     1380

atcttttgtt ttttaagtta gtgtatattt tgttgtgatt atctttttgt ggtgtgaata     1440

aatcttttat cttgaatgta ataagaattt ggtggtgtca attgcttatt tgttttccca     1500

cggttgtcca gcaattaata aaacataacc ttttttactg cctaaaaaaa aaaaaaaaaa     1560


<210>  7
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
    50                  55                  60                  


Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
65                  70                  75                  80  


Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Ser His 
                85                  90                  95      


Gln Ser Asp Glu Ser His His Ser Asp Glu Ser Asp Glu Leu Val Thr 
            100                 105                 110         


Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu Val Phe Thr Pro Val Val 
        115                 120                 125             


Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly Asp Ser Val Val Tyr Gly 
    130                 135                 140                 


Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg Pro Asp Ile Gln Tyr Pro 
145                 150                 155                 160 


Asp Ala Thr Asp Glu Asp Ile Thr Ser His Met Glu Ser Glu Glu Leu 
                165                 170                 175     


Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala Gln Asp Leu Asn Ala Pro 
            180                 185                 190         


Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser Tyr Glu Thr Ser Gln Leu 
        195                 200                 205             


Asp Asp Gln Ser Ala Glu Thr His Ser His Lys Gln Ser Arg Leu Tyr 
    210                 215                 220                 


Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu His Ser Asp Val Ile Asp 
225                 230                 235                 240 


Ser Gln Glu Leu Ser Lys Val Ser Arg Glu Phe His Ser His Glu Phe 
                245                 250                 255     


His Ser His Glu Asp Met Leu Val Val Asp Pro Lys Ser Lys Glu Glu 
            260                 265                 270         


Asp Lys His Leu Lys Phe Arg Ile Ser His Glu Leu Asp Ser Ala Ser 
        275                 280                 285             


Ser Glu Val Asn 
    290         


<210>  8
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Glu Thr Leu Pro Ser Lys Ser 
    50                  55                  60                  


Asn Glu Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp 
65                  70                  75                  80  


Asp His Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp 
                85                  90                  95      


Val Asp Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser 
            100                 105                 110         


Asp Glu Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala 
        115                 120                 125             


Thr Glu Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly 
    130                 135                 140                 


Arg Gly Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe 
145                 150                 155                 160 


Arg Arg Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr 
                165                 170                 175     


Ser His Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro 
            180                 185                 190         


Val Ala Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys 
        195                 200                 205             


Asp Ser Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His 
    210                 215                 220                 


Ser His Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser 
225                 230                 235                 240 


Asn Glu His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser 
                245                 250                 255     


Arg Glu Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val 
            260                 265                 270         


Val Asp Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile 
        275                 280                 285             


Ser His Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
    290                 295                 300 


<210>  9
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Thr 
            20                  25                  30          


Leu Pro Ser Lys Ser Asn Glu Ser His Asp His Met Asp Asp Met Asp 
        35                  40                  45              


Asp Glu Asp Asp Asp Asp His Val Asp Ser Gln Asp Ser Ile Asp Ser 
    50                  55                  60                  


Asn Asp Ser Asp Asp Val Asp Asp Thr Asp Asp Ser His Gln Ser Asp 
65                  70                  75                  80  


Glu Ser His His Ser Asp Glu Ser Asp Glu Leu Val Thr Asp Phe Pro 
                85                  90                  95      


Thr Asp Leu Pro Ala Thr Glu Val Phe Thr Pro Val Val Pro Thr Val 
            100                 105                 110         


Asp Thr Tyr Asp Gly Arg Gly Asp Ser Val Val Tyr Gly Leu Arg Ser 
        115                 120                 125             


Lys Ser Lys Lys Phe Arg Arg Pro Asp Ile Gln Tyr Pro Asp Ala Thr 
    130                 135                 140                 


Asp Glu Asp Ile Thr Ser His Met Glu Ser Glu Glu Leu Asn Gly Ala 
145                 150                 155                 160 


Tyr Lys Ala Ile Pro Val Ala Gln Asp Leu Asn Ala Pro Ser Asp Trp 
                165                 170                 175     


Asp Ser Arg Gly Lys Asp Ser Tyr Glu Thr Ser Gln Leu Asp Asp Gln 
            180                 185                 190         


Ser Ala Glu Thr His Ser His Lys Gln Ser Arg Leu Tyr Lys Arg Lys 
        195                 200                 205             


Ala Asn Asp Glu Ser Asn Glu His Ser Asp Val Ile Asp Ser Gln Glu 
    210                 215                 220                 


Leu Ser Lys Val Ser Arg Glu Phe His Ser His Glu Phe His Ser His 
225                 230                 235                 240 


Glu Asp Met Leu Val Val Asp Pro Lys Ser Lys Glu Glu Asp Lys His 
                245                 250                 255     


Leu Lys Phe Arg Ile Ser His Glu Leu Asp Ser Ala Ser Ser Glu Val 
            260                 265                 270         


Asn 
    


<210>  10
<211>  1511
<212>  DNA
<213>  Homo sapiens

<400>  10
ctccctgtgt tggtggagga tgtctgcagc agcatttaaa ttctgggagg gcttggttgt       60

cagcagcagc aggaggaggc agagcacagc atcgtcggga ccagactcgt ctcaggccag      120

ttgcagcctt ctcagccaaa cgccgaccaa ggaaaactca ctaccatgag aattgcagtg      180

atttgctttt gcctcctagg catcacctgt gccataccag ttaaacaggc tgattctgga      240

agttctgagg aaaagcagac ccttccaagt aagtccaacg aaagccatga ccacatggat      300

gatatggatg atgaagatga tgatgaccat gtggacagcc aggactccat tgactcgaac      360

gactctgatg atgtagatga cactgatgat tctcaccagt ctgatgagtc tcaccattct      420

gatgaatctg atgaactggt cactgatttt cccacggacc tgccagcaac cgaagttttc      480

actccagttg tccccacagt agacacatat gatggccgag gtgatagtgt ggtttatgga      540

ctgaggtcaa aatctaagaa gtttcgcaga cctgacatcc agtaccctga tgctacagac      600

gaggacatca cctcacacat ggaaagcgag gagttgaatg gtgcatacaa ggccatcccc      660

gttgcccagg acctgaacgc gccttctgat tgggacagcc gtgggaagga cagttatgaa      720

acgagtcagc tggatgacca gagtgctgaa acccacagcc acaagcagtc cagattatat      780

aagcggaaag ccaatgatga gagcaatgag cattccgatg tgattgatag tcaggaactt      840

tccaaagtca gccgtgaatt ccacagccat gaatttcaca gccatgaaga tatgctggtt      900

gtagacccca aaagtaagga agaagataaa cacctgaaat ttcgtatttc tcatgaatta      960

gatagtgcat cttctgaggt caattaaaag gagaaaaaat acaatttctc actttgcatt     1020

tagtcaaaag aaaaaatgct ttatagcaaa atgaaagaga acatgaaatg cttctttctc     1080

agtttattgg ttgaatgtgt atctatttga gtctggaaat aactaatgtg tttgataatt     1140

agtttagttt gtggcttcat ggaaactccc tgtaaactaa aagcttcagg gttatgtcta     1200

tgttcattct atagaagaaa tgcaaactat cactgtattt taatatttgt tattctctca     1260

tgaatagaaa tttatgtaga agcaaacaaa atacttttac ccacttaaaa agagaatata     1320

acattttatg tcactataat cttttgtttt ttaagttagt gtatattttg ttgtgattat     1380

ctttttgtgg tgtgaataaa tcttttatct tgaatgtaat aagaatttgg tggtgtcaat     1440

tgcttatttg ttttcccacg gttgtccagc aattaataaa acataacctt ttttactgcc     1500

taaaaaaaaa a                                                          1511


<210>  11
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gly Ile Val Pro Arg Ser Leu Asp Lys Lys Ala His Arg Val Gln 
1               5                   10                  15      


Phe Gln Leu Asn Arg Ile Lys Ala Lys Ile Glu Leu Pro Trp Gly Ser 
            20                  25                  30          


Leu Gln Leu Asp Cys Leu Met Lys Thr Leu Lys Glu Leu Tyr Asn Lys 
        35                  40                  45              


Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro Ser Gln Lys 
    50                  55                  60                  


Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu Glu Thr Asn 
65                  70                  75                  80  


Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu Ser His Asp 
                85                  90                  95      


His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His Val Asp Ser 
            100                 105                 110         


Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp Asp Thr Asp 
        115                 120                 125             


Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu Ser Asp Glu 
    130                 135                 140                 


Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu Val Phe Thr 
145                 150                 155                 160 


Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly Asp Ser Val 
                165                 170                 175     


Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg Pro Asp Ile 
            180                 185                 190         


Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His Met Glu Ser 
        195                 200                 205             


Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala Gln Asp Leu 
    210                 215                 220                 


Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser Tyr Glu Thr 
225                 230                 235                 240 


Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His Ser His Lys Gln Ser 
                245                 250                 255     


Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu His Ser Asp 
            260                 265                 270         


Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser Arg Glu Phe His Ser 
        275                 280                 285             


His Glu Phe His Ser His Glu Asp Met Leu Val Val Asp Pro Lys Ser 
    290                 295                 300                 


Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile Ser His Glu Leu Asp 
305                 310                 315                 320 


Ser Ala Ser Ser Glu Val Asn 
                325         


<210>  12
<211>  1823
<212>  DNA
<213>  Homo sapiens

<400>  12
ctccctgtgt tggtggagga tgtctgcagc agcatttaaa ttctgggagg gcttggttgt       60

cagcagcagc aggaggaggc agagcacagc atcgtcggga ccagactcgt ctcaggccag      120

ttgcagcctt ctcagccaaa cgccgaccaa ggaaaactca ctaccatgag aattgcagtg      180

atttgctttt gcctcctagg catcacctgt gccataccag ttaaacaggc tgattctgga      240

agttctgagg aaaagcagca ctaaagatgt acctacccct ccacaacaga tgaaactgtg      300

ccagccaaac aacaaatggg cattgtcccc agaagcttgg acaaaaaggc acacagagtt      360

caattccagt tgaacagaat aaaggccaaa atagagctgc cttgggggtc actgcaatta      420

gactgcttaa tgaagacatt aaaagaactt tacaacaaat acccagatgc tgtggccaca      480

tggctaaacc ctgacccatc tcagaagcag aatctcctag ccccacagaa tgctgtgtcc      540

tctgaagaaa ccaatgactt taaacaagag acccttccaa gtaagtccaa cgaaagccat      600

gaccacatgg atgatatgga tgatgaagat gatgatgacc atgtggacag ccaggactcc      660

attgactcga acgactctga tgatgtagat gacactgatg attctcacca gtctgatgag      720

tctcaccatt ctgatgaatc tgatgaactg gtcactgatt ttcccacgga cctgccagca      780

accgaagttt tcactccagt tgtccccaca gtagacacat atgatggccg aggtgatagt      840

gtggtttatg gactgaggtc aaaatctaag aagtttcgca gacctgacat ccagtaccct      900

gatgctacag acgaggacat cacctcacac atggaaagcg aggagttgaa tggtgcatac      960

aaggccatcc ccgttgccca ggacctgaac gcgccttctg attgggacag ccgtgggaag     1020

gacagttatg aaacgagtca gctggatgac cagagtgctg aaacccacag ccacaagcag     1080

tccagattat ataagcggaa agccaatgat gagagcaatg agcattccga tgtgattgat     1140

agtcaggaac tttccaaagt cagccgtgaa ttccacagcc atgaatttca cagccatgaa     1200

gatatgctgg ttgtagaccc caaaagtaag gaagaagata aacacctgaa atttcgtatt     1260

tctcatgaat tagatagtgc atcttctgag gtcaattaaa aggagaaaaa atacaatttc     1320

tcactttgca tttagtcaaa agaaaaaatg ctttatagca aaatgaaaga gaacatgaaa     1380

tgcttctttc tcagtttatt ggttgaatgt gtatctattt gagtctggaa ataactaatg     1440

tgtttgataa ttagtttagt ttgtggcttc atggaaactc cctgtaaact aaaagcttca     1500

gggttatgtc tatgttcatt ctatagaaga aatgcaaact atcactgtat tttaatattt     1560

gttattctct catgaataga aatttatgta gaagcaaaca aaatactttt acccacttaa     1620

aaagagaata taacatttta tgtcactata atcttttgtt ttttaagtta gtgtatattt     1680

tgttgtgatt atctttttgt ggtgtgaata aatcttttat cttgaatgta ataagaattt     1740

ggtggtgtca attgcttatt tgttttccca cggttgtcca gcaattaata aaacataacc     1800

ttttttactg cctaaaaaaa aaa                                             1823


<210>  13
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
    50                  55                  60                  


Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
65                  70                  75                  80  


Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His 
                85                  90                  95      


Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp 
            100                 105                 110         


Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu 
        115                 120                 125             


Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu 
    130                 135                 140                 


Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly 
145                 150                 155                 160 


Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg 
                165                 170                 175     


Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu His Ile Thr Ser His 
            180                 185                 190         


Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala 
        195                 200                 205             


Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser 
    210                 215                 220                 


Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His Ser His 
225                 230                 235                 240 


Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu 
                245                 250                 255     


His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser Arg Glu 
            260                 265                 270         


Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val Val Asp 
        275                 280                 285             


Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile Ser His 
    290                 295                 300                 


Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
305                 310                 


<210>  14
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
    50                  55                  60                  


Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
65                  70                  75                  80  


Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His 
                85                  90                  95      


Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp 
            100                 105                 110         


Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu 
        115                 120                 125             


Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu 
    130                 135                 140                 


Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly 
145                 150                 155                 160 


Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg 
                165                 170                 175     


Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His 
            180                 185                 190         


Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala 
        195                 200                 205             


Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser 
    210                 215                 220                 


Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Ala His Ser His 
225                 230                 235                 240 


Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu 
                245                 250                 255     


His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser Arg Glu 
            260                 265                 270         


Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val Val Asp 
        275                 280                 285             


Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile Ser His 
    290                 295                 300                 


Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
305                 310                 


<210>  15
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
    50                  55                  60                  


Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
65                  70                  75                  80  


Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His 
                85                  90                  95      


Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp 
            100                 105                 110         


Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu 
        115                 120                 125             


Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu 
    130                 135                 140                 


Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly 
145                 150                 155                 160 


Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg 
                165                 170                 175     


Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His 
            180                 185                 190         


Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala 
        195                 200                 205             


Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser 
    210                 215                 220                 


Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His Ser His 
225                 230                 235                 240 


Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu 
                245                 250                 255     


His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser Arg Glu 
            260                 265                 270         


Phe His Gly Asn Ser Leu His Ser His Glu Asp Met Leu Val Val Asp 
        275                 280                 285             


Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile Ser His 
    290                 295                 300                 


Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
305                 310                 


<210>  16
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
    50                  55                  60                  


Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
65                  70                  75                  80  


Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His 
                85                  90                  95      


Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp 
            100                 105                 110         


Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu 
        115                 120                 125             


Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu 
    130                 135                 140                 


Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly 
145                 150                 155                 160 


Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg 
                165                 170                 175     


Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His 
            180                 185                 190         


Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala 
        195                 200                 205             


Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys Asp Asn 
    210                 215                 220                 


Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His Ser His 
225                 230                 235                 240 


Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu 
                245                 250                 255     


His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser Arg Glu 
            260                 265                 270         


Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val Val Asp 
        275                 280                 285             


Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile Ser His 
    290                 295                 300                 


Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
305                 310                 


<210>  17
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
    50                  55                  60                  


Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
65                  70                  75                  80  


Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His 
                85                  90                  95      


Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp 
            100                 105                 110         


Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu 
        115                 120                 125             


Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu 
    130                 135                 140                 


Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly 
145                 150                 155                 160 


Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg 
                165                 170                 175     


Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His 
            180                 185                 190         


Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala 
        195                 200                 205             


Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser 
    210                 215                 220                 


Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His Ser His 
225                 230                 235                 240 


Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu 
                245                 250                 255     


His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser Arg Glu 
            260                 265                 270         


Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val Val Asp 
        275                 280                 285             


Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe His Ile Ser His 
    290                 295                 300                 


Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
305                 310                 


<210>  18
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Asn 
            20                  25                  30          


Ala Val Ser Ser Glu Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro 
        35                  40                  45              


Ser Lys Ser Asn Glu Ser His Asp His Met Asp Asp Met Asp Asp Glu 
    50                  55                  60                  


Asp Asp Asp Asp His Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp 
65                  70                  75                  80  


Ser Asp Asp Val Asp Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser 
                85                  90                  95      


His His Ser Asp Glu Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp 
            100                 105                 110         


Leu Pro Ala Thr Glu Val Phe Thr Pro Val Val Pro Thr Val Asp Thr 
        115                 120                 125             


Tyr Asp Gly Arg Gly Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser 
    130                 135                 140                 


Lys Lys Phe Arg Arg Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu 
145                 150                 155                 160 


Asp Ile Thr Ser His Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys 
                165                 170                 175     


Ala Ile Pro Val Ala Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser 
            180                 185                 190         


Arg Gly Lys Asp Ser Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala 
        195                 200                 205             


Glu Thr His Ser His Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn 
    210                 215                 220                 


Asp Glu Ser Asn Glu His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser 
225                 230                 235                 240 


Lys Val Ser Arg Glu Phe His Ser His Glu Phe His Ser His Glu Asp 
                245                 250                 255     


Met Leu Val Val Asp Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys 
            260                 265                 270         


Phe Arg Ile Ser His Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
        275                 280                 285         


<210>  19
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Glu Thr Leu Pro Ser Lys Ser 
    50                  55                  60                  


Asn Glu Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp 
65                  70                  75                  80  


Asp His Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp 
                85                  90                  95      


Val Asp Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser 
            100                 105                 110         


Asp Glu Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala 
        115                 120                 125             


Thr Glu Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly 
    130                 135                 140                 


Arg Gly Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe 
145                 150                 155                 160 


Arg Arg Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr 
                165                 170                 175     


Ser His Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro 
            180                 185                 190         


Val Ala Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys 
        195                 200                 205             


Asp Ser Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His 
    210                 215                 220                 


Ser His Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser 
225                 230                 235                 240 


Asn Glu His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser 
                245                 250                 255     


Arg Glu Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val 
            260                 265                 270         


Val Asp Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile 
        275                 280                 285             


Ser His Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
    290                 295                 300 


<210>  20
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Thr Leu Pro Ser Lys Ser 
    50                  55                  60                  


Asn Glu Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp 
65                  70                  75                  80  


Asp His Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp 
                85                  90                  95      


Val Asp Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser 
            100                 105                 110         


Asp Glu Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala 
        115                 120                 125             


Thr Glu Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly 
    130                 135                 140                 


Arg Gly Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe 
145                 150                 155                 160 


Arg Arg Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr 
                165                 170                 175     


Ser His Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro 
            180                 185                 190         


Val Ala Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys 
        195                 200                 205             


Asp Ser Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His 
    210                 215                 220                 


Ser His Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser 
225                 230                 235                 240 


Asn Glu His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser 
                245                 250                 255     


Arg Glu Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val 
            260                 265                 270         


Val Asp Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile 
        275                 280                 285             


Ser His Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
    290                 295                 300 


<210>  21
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
    50                  55                  60                  


Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
65                  70                  75                  80  


Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Ser His 
                85                  90                  95      


Gln Ser Asp Glu Ser His His Ser Asp Glu Ser Asp Glu Leu Val Thr 
            100                 105                 110         


Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu Val Phe Thr Pro Val Val 
        115                 120                 125             


Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly Asp Ser Val Val Tyr Gly 
    130                 135                 140                 


Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg Pro Asp Ile Gln Tyr Pro 
145                 150                 155                 160 


Asp Ala Thr Asp Glu Asp Ile Thr Ser His Met Glu Ser Glu Glu Leu 
                165                 170                 175     


Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala Gln Asp Leu Asn Ala Pro 
            180                 185                 190         


Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser Tyr Glu Thr Ser Gln Leu 
        195                 200                 205             


Asp Asp Gln Ser Ala Glu Thr His Ser His Lys Gln Ser Arg Leu Tyr 
    210                 215                 220                 


Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu His Ser Asp Val Ile Asp 
225                 230                 235                 240 


Ser Gln Glu Leu Ser Lys Val Ser Arg Glu Phe His Ser His Glu Phe 
                245                 250                 255     


His Ser His Glu Asp Met Leu Val Val Asp Pro Lys Ser Lys Glu Glu 
            260                 265                 270         


Asp Lys His Leu Lys Phe Arg Ile Ser His Glu Leu Asp Ser Ala Ser 
        275                 280                 285             


Ser Glu Val Asn 
    290         


<210>  22
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is null

<400>  22

Xaa Arg Gly Asp 
1               


<210>  23
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  23

Gly Arg Gly Asp Ser 
1               5   


<210>  24
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  24

Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr 
1               5                   10              


<210>  25
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  25

Ser Val Val Tyr Gly Leu Arg 
1               5           


<210>  26
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  26

Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile Ser His Glu 
1               5                   10                  15      


<210>  27
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  27

Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg Pro Asp Ile Gln Tyr Pro 
1               5                   10                  15      


Asp Ala Thr Asp Glu Asp Ile Thr Ser His Met Glu Ser Glu Glu Leu 
            20                  25                  30          


Asn Gly Ala Tyr Lys Ala Ile Pro 
        35                  40  


