                         SEQUENCE LISTING

<110>  Tel HaShomer Medical Research Infrastructure and Services 
       Ltd.
       Tageza Biopharmaceuticals Ltd.
       DEKEL, Benjamin
       HARARI-STEINBERG, Orit
 
<120>  COMPOSITIONS TARGETING GPM6A AND METHODS FOR DIAGNOSIS AND 
       TREATMENT OF CANCER

<130>  83889

<150>  US 62/884,208
<151>  2019-08-08

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  398
<212>  DNA
<213>  Artificial sequence

<220>
<223>  heavy chain nucleic acid sequence with signal sequence

<400>  1
tgaaattcag ctgggtcatc ttcttcctga tggcagtggt tacaggggtc aattcagagg       60

ttcagctgca gcagtctgtg gcagagcttg tgaggccagg ggcctcagtc aagttgtcct      120

gcacagcttc tggcttcaac attaaaaacg cctatgtgca ctgggtgaag cagaggcctg      180

aacagggcct ggagtggatt ggaaggattg atcctgcgaa tggtattact aaatttgccc      240

cgaaattcca gggcaaggcc actttaactg cagacacatc ctccaacaca gcctacctgc      300

agctcagcag cctgacatct gaggacactg ccatctatta ctgtgctaga gggggtagca      360

gcgggtgggg tcaaggaacc tcagtcaccg tctcctca                              398


<210>  2
<211>  342
<212>  DNA
<213>  Artificial sequence

<220>
<223>  heavy chain nucleic acid sequence

<400>  2
gaggttcagc tgcagcagtc tgtggcagag cttgtgaggc caggggcctc agtcaagttg       60

tcctgcacag cttctggctt caacattaaa aacgcctatg tgcactgggt gaagcagagg      120

cctgaacagg gcctggagtg gattggaagg attgatcctg cgaatggtat tactaaattt      180

gccccgaaat tccagggcaa ggccacttta actgcagaca catcctccaa cacagcctac      240

ctgcagctca gcagcctgac atctgaggac actgccatct attactgtgc tagagggggt      300

agcagcgggt ggggtcaagg aacctcagtc accgtctcct ca                         342


<210>  3
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  omplementarity-determining region (CDR) sequence

<400>  3
aacgcctatg tgcac                                                        15


<210>  4
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  omplementarity-determining region (CDR) sequence

<400>  4
aggattgatc ctgcgaatgg tattactaaa tttgccccga aattccaggg c                51


<210>  5
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  omplementarity-determining region (CDR) sequence

<400>  5
gggggtagca gcggg                                                        15


<210>  6
<211>  133
<212>  PRT
<213>  Artificial sequence

<220>
<223>  heavy chain amino acid sequence with signal sequence

<400>  6

Met Lys Phe Ser Trp Val Ile Phe Phe Leu Met Ala Val Val Thr Gly 
1               5                   10                  15      


Val Asn Ser Glu Val Gln Leu Gln Gln Ser Val Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asn Ala Tyr Val His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Asp Pro Ala Asn Gly Ile Thr Lys Phe Ala 
65                  70                  75                  80  


Pro Lys Phe Gln Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Gly Ser Ser Gly Trp Gly Gln Gly Thr Ser 
        115                 120                 125             


Val Thr Val Ser Ser 
    130             


<210>  7
<211>  114
<212>  PRT
<213>  Artificial sequence

<220>
<223>  heavy chain amino acid sequence

<400>  7

Glu Val Gln Leu Gln Gln Ser Val Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asn Ala 
            20                  25                  30          


Tyr Val His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Ile Thr Lys Phe Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ser Ser Gly Trp Gly Gln Gly Thr Ser Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  8
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  omplementarity-determining region (CDR) sequence

<400>  8

Asn Ala Tyr Val His 
1               5   


<210>  9
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  omplementarity-determining region (CDR) sequence

<400>  9

Arg Ile Asp Pro Ala Asn Gly Ile Thr Lys Phe Ala Pro Lys Phe Gln 
1               5                   10                  15      


<210>  10
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  omplementarity-determining region (CDR) sequence

<400>  10

Gly Gly Ser Ser Gly 
1               5   


<210>  11
<211>  393
<212>  DNA
<213>  Artificial sequence

<220>
<223>  light chain nucleic acid sequence with signal sequence

<400>  11
atgagtcctg cccagttcct gtttctgtta gtgctctgga ttcgggaaac caacggtgat       60

gttgtgatga cccagactcc actcactttg tcggttacca ttggacaacc agcctccatc      120

tcttgcaagt caagtcagag cctcttagat actgatggaa agacatattt gaattggttg      180

ttacagaggc caggccagtc tccaaagcgc ctaatctatc tggtgtctaa gctggactct      240

ggagcccctg acaggttcac tggcagtgga tcagggacag atttcacact gaaaatcagc      300

agagtggagg ctgaggattt gggactttat tattgctggc aaggtacaca ttttccgctc      360

acgttcggtg ctgggaccaa gctggagctg aaa                                   393


<210>  12
<211>  336
<212>  DNA
<213>  Artificial sequence

<220>
<223>  light chain nucleic acid sequence

<400>  12
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc       60

atctcttgca agtcaagtca gagcctctta gatactgatg gaaagacata tttgaattgg      120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taagctggac      180

tctggagccc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgagga tttgggactt tattattgct ggcaaggtac acattttccg      300

ctcacgttcg gtgctgggac caagctggag ctgaaa                                336


<210>  13
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  omplementarity-determining region (CDR) sequence

<400>  13
aagtcaagtc agagcctctt agatactgat ggaaagacat atttgaat                    48


<210>  14
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  omplementarity-determining region (CDR) sequence

<400>  14
ctggtgtcta agctggactc                                                   20


<210>  15
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  omplementarity-determining region (CDR) sequence

<400>  15
tggcaaggta cacattttcc gctcacg                                           27


<210>  16
<211>  131
<212>  PRT
<213>  Artificial sequence

<220>
<223>  light chain amino acid sequence with signal sequence

<400>  16

Met Ser Pro Ala Gln Phe Leu Phe Leu Leu Val Leu Trp Ile Arg Glu 
1               5                   10                  15      


Thr Asn Gly Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val 
            20                  25                  30          


Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu Asp Thr Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser 
65                  70                  75                  80  


Gly Ala Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Tyr Cys 
            100                 105                 110         


Trp Gln Gly Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
        115                 120                 125             


Glu Leu Lys 
    130     


<210>  17
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  light chain amino acid sequence

<400>  17

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Thr 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Ala Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  18
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  omplementarity-determining region (CDR) sequence

<400>  18

Lys Ser Ser Gln Ser Leu Leu Asp Thr Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  19
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  omplementarity-determining region (CDR) sequence

<400>  19

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  omplementarity-determining region (CDR) sequence

<400>  20

Trp Gln Gly Thr His Phe Pro Leu Thr 
1               5                   


<210>  21
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  human GPM6A protein antigen

<400>  21

Cys Glu Met Ala Arg Thr Ala Gly Asp Thr Leu Asp Val Phe Thr 
1               5                   10                  15  


<210>  22
<211>  278
<212>  PRT
<213>  homo sapiens

<400>  22

Met Glu Glu Asn Met Glu Glu Gly Gln Thr Gln Lys Gly Cys Phe Glu 
1               5                   10                  15      


Cys Cys Ile Lys Cys Leu Gly Gly Ile Pro Tyr Ala Ser Leu Ile Ala 
            20                  25                  30          


Thr Ile Leu Leu Tyr Ala Gly Val Ala Leu Phe Cys Gly Cys Gly His 
        35                  40                  45              


Glu Ala Leu Ser Gly Thr Val Asn Ile Leu Gln Thr Tyr Phe Glu Met 
    50                  55                  60                  


Ala Arg Thr Ala Gly Asp Thr Leu Asp Val Phe Thr Met Ile Asp Ile 
65                  70                  75                  80  


Phe Lys Tyr Val Ile Tyr Gly Ile Ala Ala Ala Phe Phe Val Tyr Gly 
                85                  90                  95      


Ile Leu Leu Met Val Glu Gly Phe Phe Thr Thr Gly Ala Ile Lys Asp 
            100                 105                 110         


Leu Tyr Gly Asp Phe Lys Ile Thr Thr Cys Gly Arg Cys Val Ser Ala 
        115                 120                 125             


Trp Phe Ile Met Leu Thr Tyr Leu Phe Met Leu Ala Trp Leu Gly Val 
    130                 135                 140                 


Thr Ala Phe Thr Ser Leu Pro Val Tyr Met Tyr Phe Asn Leu Trp Thr 
145                 150                 155                 160 


Ile Cys Arg Asn Thr Thr Leu Val Glu Gly Ala Asn Leu Cys Leu Asp 
                165                 170                 175     


Leu Arg Gln Phe Gly Ile Val Thr Ile Gly Glu Glu Lys Lys Ile Cys 
            180                 185                 190         


Thr Val Ser Glu Asn Phe Leu Arg Met Cys Glu Ser Thr Glu Leu Asn 
        195                 200                 205             


Met Thr Phe His Leu Phe Ile Val Ala Leu Ala Gly Ala Gly Ala Ala 
    210                 215                 220                 


Val Ile Ala Met Val His Tyr Leu Met Val Leu Ser Ala Asn Trp Ala 
225                 230                 235                 240 


Tyr Val Lys Asp Ala Cys Arg Met Gln Lys Tyr Glu Asp Ile Lys Ser 
                245                 250                 255     


Lys Glu Glu Gln Glu Leu His Asp Ile His Ser Thr Arg Ser Lys Glu 
            260                 265                 270         


Arg Leu Asn Ala Tyr Thr 
        275             


<210>  23
<211>  41
<212>  PRT
<213>  homo sapiens

<400>  23

Cys Gly Cys Gly His Glu Ala Leu Ser Gly Thr Val Asn Ile Leu Gln 
1               5                   10                  15      


Thr Tyr Phe Glu Met Ala Arg Thr Ala Gly Asp Thr Leu Asp Val Phe 
            20                  25                  30          


Thr Met Ile Asp Ile Phe Lys Tyr Val 
        35                  40      


<210>  24
<211>  14
<212>  PRT
<213>  homo sapiens

<400>  24

Glu Met Ala Arg Thr Ala Gly Asp Thr Leu Asp Val Phe Thr 
1               5                   10                  


