               SEQUENCE LISTING

<110> Fundacio Clínic per  a la Recerca Biomedica
      Hospital Clínic de Barcelona
      Institut d’Investigacions Biomèdiques August Pi i Sunyer
      (IDIBAPS)
      Universitat de Barcelona

<120> CAR T-cells for the treatment of Multiple myeloma

<130> 905 487

<150> EP19382673.2
<151> 2019-08-02

<160> 16

<170> BiSSAP 1.3.6

<210> 1
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<221> PEPTIDE
<222> 1..120

<220> 
<223> VH domain

<400> 1
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Phe Ser Arg Tyr 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  
Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 

<210> 2
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<221> PEPTIDE
<222> 1..107

<220> 
<223> VL domain

<400> 2
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp Ser Asn 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ala Leu Ile 
        35                  40                  45              
Phe Ser Ala Ser Leu Arg Phe Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 3
<211> 242
<212> PRT
<213> Artificial Sequence


<220> 
<221> PEPTIDE
<222> 1..242

<220> 
<223> VL and VH domain

<400> 3
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Phe Ser Arg Tyr 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  
Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala 
145                 150                 155                 160 
Ser Gln Ser Val Asp Ser Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     
Lys Ala Pro Lys Ala Leu Ile Phe Ser Ala Ser Leu Arg Phe Ser Gly 
            180                 185                 190         
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             
Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 
Gln Tyr Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
225                 230                 235                 240 
Ile Lys 
        

<210> 4
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<221> PEPTIDE
<222> 1..15

<220> 
<223> Linker

<400> 4
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

<210> 5
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<221> PEPTIDE
<222> 1..20

<220> 
<223> signal peptide

<400> 5
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      
Asp Thr Thr Gly 
            20  

<210> 6
<211> 262
<212> PRT
<213> Artificial Sequence


<220> 
<221> PEPTIDE
<222> 1..262

<220> 
<223> BCMA -targeting moiety

<400> 6
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      
Asp Thr Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          
Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp 
        35                  40                  45              
Phe Ser Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  
Leu Glu Trp Ile Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr 
65                  70                  75                  80  
Ala Pro Ser Leu Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      
Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         
Val Tyr Tyr Cys Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Met Asp 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
145                 150                 155                 160 
Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     
Thr Cys Lys Ala Ser Gln Ser Val Asp Ser Asn Val Ala Trp Tyr Gln 
            180                 185                 190         
Gln Lys Pro Gly Lys Ala Pro Lys Ala Leu Ile Phe Ser Ala Ser Leu 
        195                 200                 205             
Arg Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 
Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 
Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly 
                245                 250                 255     
Thr Lys Val Glu Ile Lys 
            260         

<210> 7
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<221> PEPTIDE
<222> 1..23

<220> 
<223> Transmembrane domain derived from CD8a

<400> 7
Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
1               5                   10                  15      
Leu Val Ile Thr Leu Tyr Cys 
            20              

<210> 8
<211> 46
<212> PRT
<213> Artificial Sequence


<220> 
<221> PEPTIDE
<222> 1..46

<220> 
<223> Hinge domain

<400> 8
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        35                  40                  45      

<210> 9
<211> 69
<212> PRT
<213> Artificial Sequence


<220> 
<221> PEPTIDE
<222> 1..69

<220> 
<223> transmembrane domain further comprises a CD8 hinge

<400> 9
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              
Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  
Ile Thr Leu Tyr Cys 
65                  

<210> 10
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<221> PEPTIDE
<222> 1..113

<220> 
<223> Intracellular signaling domain

<400> 10
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              
Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  
Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  
Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      
Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         
Arg 
    

<210> 11
<211> 42
<212> PRT
<213> Artificial Sequence


<220> 
<221> PEPTIDE
<222> 1..42

<220> 
<223> costimulatory signaling domain

<400> 11
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          

<210> 12
<211> 1460
<212> DNA
<213> Artificial Sequence


<220> 
<223> full nucleotide sequence of the CAR

<220> 
<221> misc_feature
<222> 1..1460

<400> 12
atggaggctc cagcacagct cctttttctg ctcctcctgt ggctccctga tacgaccgga      60

gaagttcaac tcgtggagag cggtggggga ctcgtacagc caggtggatc tctcagactt     120

tcctgcgctg catcaggcat agactttagt cggtactgga tgagttgggt acgacaagct     180

cctgggaagg gcttggaatg gattggtgaa atcaacccgg acagcagcac cataaattat     240

gctccaagct tgaaagaccg gttcactata tctcgggata atgctaaaaa ctccctttac     300

cttcagatga atagtctccg ggcggaagat acggcggtgt attactgtgc ttctctgtac     360

tacgactatg gcgatgcaat ggactattgg ggccaaggta cgctggtgac cgtctcatct     420

ggggggggag gtagtggagg aggaggttca ggggggggcg gaagtgatat tcaaatgaca     480

cagtctccgt cttcactgag tgcttctgta ggggatcgag ttacgatcac ttgtaaggcc     540

agccaatccg tggattctaa tgttgcgtgg tatcagcaga agcccggcaa agcgcctaaa     600

gcactgatat ttagcgcatc actccgcttt tccggggtcc cctccaggtt cagtggtagc     660

gggtctggaa cagacttcac tctcactata tcttcattgc aaccagaaga cttcgcgacc     720

tattactgtc agcaatacaa taactacccg cttacgttcg gcggcggcac taaagtcgaa     780

atcaagacga cgacgccggc gccgagacca cctacacctg caccaactat tgcctctcag     840

ccactgagtc tgcgccccga ggcatgtcga cctgccgctg gcggggctgt gcacaccagg     900

ggcctagact tcgcctgcga tatctatatt tgggctccac tggcaggaac ctgtggcgtg     960

ctgctgctgt ctctggtcat cacactgtac tgcaaaagag gcaggaagaa actgctgtat    1020

attttcaagc agccctttat gagacctgtg cagacaactc aggaggaaga cgggtgcagc    1080

tgtaggttcc ctgaggaaga ggaaggaggc tgtgagctgc gcgtgaaatt ttctcggagt    1140

gcagatgccc cagcttacca gcagggccag aaccagctgt ataacgagct gaatctgggg    1200

cggagagagg aatacgacgt gctggataag aggcgcgggc gagatccaga aatgggagga    1260

aaaccccagc gacggaagaa ccctcaggag ggactgtaca atgaactgca gaaggacaaa    1320

atggcagagg cctattccga aatcgggatg aaaggagaaa gaaggcgcgg caaggggcat    1380

gatggcctgt atcagggact gtcaaccgca acaaaagata cttatgatgc tctgcacatg    1440

caggctctgc ccccgcggta                                                1460


<210> 13
<211> 486
<212> PRT
<213> Artificial Sequence


<220> 
<221> PEPTIDE
<222> 1..486

<220> 
<223> full amino acid sequence of the CAR

<400> 13
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      
Asp Thr Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          
Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp 
        35                  40                  45              
Phe Ser Arg Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  
Leu Glu Trp Ile Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr 
65                  70                  75                  80  
Ala Pro Ser Leu Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      
Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         
Val Tyr Tyr Cys Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Met Asp 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
145                 150                 155                 160 
Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     
Thr Cys Lys Ala Ser Gln Ser Val Asp Ser Asn Val Ala Trp Tyr Gln 
            180                 185                 190         
Gln Lys Pro Gly Lys Ala Pro Lys Ala Leu Ile Phe Ser Ala Ser Leu 
        195                 200                 205             
Arg Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 
Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 
Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu Thr Phe Gly Gly Gly 
                245                 250                 255     
Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         
Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             
Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 
Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 
Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                325                 330                 335     
Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         
Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             
Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 
Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 
Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     
Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         
Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             
Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 
Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 
Gln Ala Leu Pro Pro Arg 
                485     

<210> 14
<211> 486
<212> PRT
<213> Artificial Sequence


<220> 
<223> MURINE (ARI2m)

<400> 14
Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      
Asp Thr Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val 
            20                  25                  30          
Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ile Asp 
        35                  40                  45              
Phe Ser Arg Tyr Trp Met Ser Trp Val Arg Arg Ala Pro Gly Lys Gly 
    50                  55                  60                  
Leu Glu Trp Ile Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr 
65                  70                  75                  80  
Ala Pro Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      
Asn Thr Leu Tyr Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala 
            100                 105                 110         
Leu Tyr Tyr Cys Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Met Asp 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
145                 150                 155                 160 
Gln Ser Gln Arg Phe Met Thr Thr Ser Val Gly Asp Arg Val Ser Val 
                165                 170                 175     
Thr Cys Lys Ala Ser Gln Ser Val Asp Ser Asn Val Ala Trp Tyr Gln 
            180                 185                 190         
Gln Lys Pro Arg Gln Ser Pro Lys Ala Leu Ile Phe Ser Ala Ser Leu 
        195                 200                 205             
Arg Phe Ser Gly Val Pro Ala Arg Phe Thr Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 
Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Ser Glu Asp Leu Ala Glu 
225                 230                 235                 240 
Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Leu Thr Phe Gly Ala Gly 
                245                 250                 255     
Thr Lys Leu Glu Leu Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         
Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             
Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 
Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val 
305                 310                 315                 320 
Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys 
                325                 330                 335     
Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
            340                 345                 350         
Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
        355                 360                 365             
Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 
Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 
Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     
Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         
Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             
Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 
Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 
Gln Ala Leu Pro Pro Arg 
                485     

<210> 15
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> murine VH

<400> 15
Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ile Asp Phe Ser Arg Tyr 
            20                  25                  30          
Trp Met Ser Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  
Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 

<210> 16
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Murine VL

<400> 16
Asp Ile Val Met Thr Gln Ser Gln Arg Phe Met Thr Thr Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Ser Val Asp Ser Asn 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Arg Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              
Phe Ser Ala Ser Leu Arg Phe Ser Gly Val Pro Ala Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Ser 
65                  70                  75                  80  
Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

