                         SEQUENCE LISTING

<110>  Immatics Biotechnologies GmbH
 
<120>  Recruiting Agent further binding an MHC molecule

<130>  1017-23 PCT

<150>  DE 10 2019 121 022.4
<151>  2019-08-02

<150>  US 62/882,364
<151>  2019-08-02

<160>  286   

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL5_CDRL1

<400>  1

Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn 
1               5                   10      


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL5_CDR_L2

<400>  2

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL5_CDRL3

<400>  3

Gln Gln Gly Gln Thr Leu Pro Trp Thr 
1               5                   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1_consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  wherein Xaa is any amino acid, preferably G or E, more preferably
       G

<400>  4

Xaa Tyr Thr Met Asn 
1               5   


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2_consensus


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  wherein Xaa is any amino acid, preferably Q,Y or E, more 
       preferably Q

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  wherein Xaa is any amino acid, preferably R, K or E, more 
       preferably R or K, such as K

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  wherein Xaa is any amino acid, preferably  S or T, more 
       preferably S

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  wherein Xaa is any amino acid, preferably F or V, more preferably
       F

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  wherein Xaa is any amino acid, prefreably G or D, more preferably
       D

<400>  5

Leu Ile Asn Pro Xaa Xaa Gly Val Xaa Thr Tyr Ala Gln Lys Xaa Gln 
1               5                   10                  15      


Xaa 
    


<210>  6
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3_consensus


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  wherein Xaa is any amino acid, preferably D or E, more preferably
       D

<400>  6

Ser Gly Tyr Tyr Gly Xaa Ser Trp Tyr Phe Asp Val 
1               5                   10          


<210>  7
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRH2_ VH2,8,16,19,20

<400>  7

Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  8
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRH3_VH2-15,19,21

<400>  8

Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val 
1               5                   10              


<210>  9
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRAME-004

<400>  9

Ser Leu Leu Gln His Leu Ile Gly Leu 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAG-003

<400>  10

Lys Val Leu Glu His Val Val Arg Val 
1               5                   


<210>  11
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR1-a (L)

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  12
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR2-a (L)

<400>  12

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR2-a (L)

<400>  13

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  14
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR3-a (L)

<400>  14

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys 
            20                  25                  30          


<210>  15
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR4-a (L)

<400>  15

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
1               5                   10      


<210>  16
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR1-b (H)

<400>  16

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr 
            20                  25                  30  


<210>  17
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR2-b (H)

<400>  17

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  18
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR3-b (H)

<400>  18

Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  19
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FR3-b (H)

<400>  19

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  20
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Va_114_iso0

<400>  20

Glu Asp Val Glu Gln Ser Leu Phe Leu Ser Val Arg Glu Gly Asp Ser 
1               5                   10                  15      


Val Val Ile Asn Cys Thr Tyr Thr Asp Ser Ser Ser Thr Tyr Leu Tyr 
            20                  25                  30          


Trp Tyr Lys Gln Glu Pro Gly Lys Gly Leu Gln Leu Leu Thr Tyr Ile 
        35                  40                  45              


Tyr Ser Ser Gln Asp Ser Lys Gln Asp Gln Arg Leu Thr Val Leu Leu 
    50                  55                  60                  


Asn Lys Lys Asp Lys His Leu Ser Leu Arg Ile Ala Asp Thr Gln Thr 
65                  70                  75                  80  


Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu Met Thr Ser Glu Ser Lys 
                85                  90                  95      


Ile Ile Phe Gly Ser Gly Thr Arg Leu Ser Ile Arg Pro 
            100                 105                 


<210>  21
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Va_114_iso1

<400>  21

Glu Asp Val Glu Gln Ser Leu Phe Leu Ser Val Arg Glu Gly Asp Ser 
1               5                   10                  15      


Val Val Ile Asn Cys Thr Tyr Thr Asp Ser Ser Ser Thr Tyr Leu Tyr 
            20                  25                  30          


Trp Tyr Lys Gln Glu Pro Gly Lys Gly Leu Gln Leu Leu Thr Tyr Ile 
        35                  40                  45              


Tyr Ser Ser Gln Asp Gln Lys Gln Asp Gln Arg Leu Thr Val Leu Leu 
    50                  55                  60                  


Asn Lys Lys Asp Lys His Leu Ser Leu Arg Ile Ala Asp Thr Gln Thr 
65                  70                  75                  80  


Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu Met Thr Ser Glu Ser Lys 
                85                  90                  95      


Ile Ile Phe Gly Ser Gly Thr Arg Leu Ser Ile Arg Pro 
            100                 105                 


<210>  22
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Va_114_iso2

<400>  22

Glu Asp Val Glu Gln Ser Leu Phe Leu Ser Val Arg Glu Gly Asp Ser 
1               5                   10                  15      


Val Val Ile Asn Cys Thr Tyr Thr Glu Ser Ser Ser Thr Tyr Leu Tyr 
            20                  25                  30          


Trp Tyr Lys Gln Glu Pro Gly Lys Gly Leu Gln Leu Leu Thr Tyr Ile 
        35                  40                  45              


Tyr Ser Ser Gln Asp Gln Lys Gln Asp Gln Arg Leu Thr Val Leu Leu 
    50                  55                  60                  


Asn Lys Lys Asp Lys His Leu Ser Leu Arg Ile Ala Asp Thr Gln Thr 
65                  70                  75                  80  


Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu Met Thr Ser Glu Ser Lys 
                85                  90                  95      


Ile Ile Phe Gly Ser Gly Thr Arg Leu Ser Ile Arg Pro 
            100                 105                 


<210>  23
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Va_114_iso0/1_CDRa1

<400>  23

Asp Ser Ser Ser Thr Tyr 
1               5       


<210>  24
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Va_114_iso0_CDRa2

<400>  24

Ile Tyr Ser Ser Gln Asp Ser 
1               5           


<210>  25
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Va_114_CDRa3

<400>  25

Cys Ala Glu Met Thr Ser Glu Ser Lys Ile Ile Phe 
1               5                   10          


<210>  26
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Va_114_iso1/2_CDRa2

<400>  26

Ile Tyr Ser Ser Gln Asp Gln 
1               5           


<210>  27
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Va_114_iso2_CDRa1

<400>  27

Glu Ser Ser Ser Thr Tyr 
1               5       


<210>  28
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  28

Gly Gly Ser Gly Gly 
1               5   


<210>  29
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  29

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10  


<210>  30
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Vb_114

<400>  30

Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
1               5                   10                  15      


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Pro Gly His Asp Tyr Leu 
            20                  25                  30          


Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu Leu Phe Tyr 
        35                  40                  45              


Phe Cys Tyr Gly Thr Pro Cys Asp Asp Ser Gly Met Pro Glu Asp Arg 
    50                  55                  60                  


Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln 
65                  70                  75                  80  


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Arg Ala 
                85                  90                  95      


Asp Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg Leu Thr Val Leu 
            100                 105                 110         


<210>  31
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Vb_114_CDRb1 (rather PGHDY)

<400>  31

Gly His Asp Tyr 
1               


<210>  32
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  32

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15  


<210>  33
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  33

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly 
            20  


<210>  34
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Vb_114_CDRb2

<400>  34

Phe Cys Tyr Gly Thr Pro 
1               5       


<210>  35
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Vb_114_CDRb3

<400>  35

Cys Ala Ser Arg Ala Asp Thr Gly Glu Leu Phe Phe 
1               5                   10          


<210>  36
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL mUCHT1

<400>  36

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  37
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH_mUCHT1

<400>  37

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  38
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL_V9_Shalaby

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  39
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH_V9_Shalaby

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  40
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL_BMA_Shearman

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ile Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  41
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH_BMA_Shearman

<400>  41

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Asp Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  42
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL_BMA(36)

<400>  42

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  43
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH_BMA(36)

<400>  43

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  44
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HiAff1_Vb

<400>  44

Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys Thr Arg Gly 
1               5                   10                  15      


Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Pro Gly His Arg Ala Val 
            20                  25                  30          


Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe Leu Phe Glu 
        35                  40                  45              


Tyr Val His Gly Glu Glu Arg Asn Lys Gly Asn Phe Pro Gly Arg Phe 
    50                  55                  60                  


Ser Gly Arg Gln Phe Ser Asn Ser Ser Ser Glu Met Asn Ile Ser Asn 
65                  70                  75                  80  


Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Pro Trp 
                85                  90                  95      


Asp Ser Pro Asn Val Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Thr Glu Asp Leu Lys Asn 
        115             


<210>  45
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HiAff1_CDRb1

<400>  45

Pro Gly His Arg Ala 
1               5   


<210>  46
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HiAff1_CDRb2

<400>  46

Tyr Val His Gly Glu Glu 
1               5       


<210>  47
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HiAff1_CDRb3

<400>  47

Cys Ala Ser Ser Pro Trp Asp Ser Pro Asn Val Gln Tyr Phe 
1               5                   10                  


<210>  48
<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HiAff1_Va

<400>  48

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Gln Glu Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Asp Asn Asp 
                85                  90                  95      


Gln Gly Gly Ile Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn 
        115         


<210>  49
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HiAff1_CDRa1

<400>  49

Asp Arg Gly Ser Gln Ser 
1               5       


<210>  50
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HiAff1_CDRa2

<400>  50

Ile Tyr Gln Glu Gly Asp 
1               5       


<210>  51
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HiAff1_CDRa3

<400>  51

Cys Ala Ala Val Ile Asp Asn Asp Gln Gly Gly Ile Leu Thr Phe 
1               5                   10                  15  


<210>  52
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  52

Tyr Leu Tyr Asp Ser Glu Thr Lys Asn Ala 
1               5                   10  


<210>  53
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  53

His Leu Met Asp Gln Pro Leu Ser Val 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  54

Gly Leu Leu Lys Lys Ile Asn Ser Val 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  55

Phe Leu Val Asp Gly Ser Ser Ala Leu 
1               5                   


<210>  56
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  56

Phe Leu Phe Asp Gly Ser Ala Asn Leu Val 
1               5                   10  


<210>  57
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  57

Phe Leu Tyr Lys Ile Ile Asp Glu Leu 
1               5                   


<210>  58
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  58

Phe Ile Leu Asp Ser Ala Glu Thr Thr Thr Leu 
1               5                   10      


<210>  59
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  59

Ser Val Asp Val Ser Pro Pro Lys Val 
1               5                   


<210>  60
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  60

Val Ala Asp Lys Ile His Ser Val 
1               5               


<210>  61
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  61

Ile Val Asp Asp Leu Thr Ile Asn Leu 
1               5                   


<210>  62
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  62

Gly Leu Leu Glu Glu Leu Val Thr Val 
1               5                   


<210>  63
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  63

Thr Leu Asp Gly Ala Ala Val Asn Gln Val 
1               5                   10  


<210>  64
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  64

Ser Val Leu Glu Lys Glu Ile Tyr Ser Ile 
1               5                   10  


<210>  65
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  65

Leu Leu Asp Pro Lys Thr Ile Phe Leu 
1               5                   


<210>  66
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  66

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25  


<210>  67
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  67

Tyr Leu Met Asp Asp Phe Ser Ser Leu 
1               5                   


<210>  68
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  68

Lys Val Trp Ser Asp Val Thr Pro Leu 
1               5                   


<210>  69
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  69

Leu Leu Trp Gly His Pro Arg Val Ala Leu Ala 
1               5                   10      


<210>  70
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  70

Lys Ile Trp Glu Glu Leu Ser Val Leu Glu Val 
1               5                   10      


<210>  71
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  71

Leu Leu Ile Pro Phe Thr Ile Phe Met 
1               5                   


<210>  72
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  72

Phe Leu Ile Glu Asn Leu Leu Ala Ala 
1               5                   


<210>  73
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  73

Leu Leu Trp Gly His Pro Arg Val Ala Leu Ala 
1               5                   10      


<210>  74
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  74

Phe Leu Leu Glu Arg Glu Gln Leu Leu 
1               5                   


<210>  75
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  75

Ser Leu Ala Glu Thr Ile Phe Ile Val 
1               5                   


<210>  76
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  76

Thr Leu Leu Glu Gly Ile Ser Arg Ala 
1               5                   


<210>  77
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  77

Ile Leu Gln Asp Gly Gln Phe Leu Val 
1               5                   


<210>  78
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  78

Val Ile Phe Glu Gly Glu Pro Met Tyr Leu 
1               5                   10  


<210>  79
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  79

Ser Leu Phe Glu Ser Leu Glu Tyr Leu 
1               5                   


<210>  80
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  80

Ser Leu Leu Asn Gln Pro Lys Ala Val 
1               5                   


<210>  81
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  81

Gly Leu Ala Glu Phe Gln Glu Asn Val 
1               5                   


<210>  82
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  82

Lys Leu Leu Ala Val Ile His Glu Leu 
1               5                   


<210>  83
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  83

Thr Leu His Asp Gln Val His Leu Leu 
1               5                   


<210>  84
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  84

Thr Leu Tyr Asn Pro Glu Arg Thr Ile Thr Val 
1               5                   10      


<210>  85
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  85

Lys Leu Gln Glu Lys Ile Gln Glu Leu 
1               5                   


<210>  86
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  86

Ser Val Leu Glu Lys Glu Ile Tyr Ser Ile 
1               5                   10  


<210>  87
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  87

Arg Val Ile Asp Asp Ser Leu Val Val Gly Val 
1               5                   10      


<210>  88
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  88

Val Leu Phe Gly Glu Leu Pro Ala Leu 
1               5                   


<210>  89
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  89

Gly Leu Val Asp Ile Met Val His Leu 
1               5                   


<210>  90
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  90

Phe Leu Asn Ala Ile Glu Thr Ala Leu 
1               5                   


<210>  91
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  91

Ala Leu Leu Gln Ala Leu Met Glu Leu 
1               5                   


<210>  92
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  92

Ala Leu Ser Ser Ser Gln Ala Glu Val 
1               5                   


<210>  93
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  93

Ser Leu Ile Thr Gly Gln Asp Leu Leu Ser Val 
1               5                   10      


<210>  94
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  94

Gln Leu Ile Glu Lys Asn Trp Leu Leu 
1               5                   


<210>  95
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  95

Leu Leu Asp Pro Lys Thr Ile Phe Leu 
1               5                   


<210>  96
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  96

Arg Leu His Asp Glu Asn Ile Leu Leu 
1               5                   


<210>  97
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  97

Gly Ser Ala Asp Asp Ala Lys Lys Asp Ala Ala Lys Lys Asp Gly Lys 
1               5                   10                  15      


Ser 
    


<210>  98
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  98

Gly Leu Pro Ser Ala Thr Thr Thr Val 
1               5                   


<210>  99
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  99

Gly Leu Leu Pro Ser Ala Glu Ser Ile Lys Leu 
1               5                   10      


<210>  100
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  100

Lys Thr Ala Ser Ile Asn Gln Asn Val 
1               5                   


<210>  101
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  101

Tyr Leu Met Asp Asp Phe Ser Ser Leu 
1               5                   


<210>  102
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  102

Leu Met Tyr Pro Tyr Ile Tyr His Val 
1               5                   


<210>  103
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  103

Lys Val Trp Ser Asp Val Thr Pro Leu 
1               5                   


<210>  104
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  104

Leu Leu Trp Gly His Pro Arg Val Ala Leu Ala 
1               5                   10      


<210>  105
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  105

Val Leu Asp Gly Lys Val Ala Val Val 
1               5                   


<210>  106
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  106

Gly Leu Leu Gly Lys Val Thr Ser Val 
1               5                   


<210>  107
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  107

Lys Met Ile Ser Ala Ile Pro Thr Leu 
1               5                   


<210>  108
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  108

Gly Leu Leu Glu Thr Thr Gly Leu Leu Ala Thr 
1               5                   10      


<210>  109
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  109

Thr Leu Asn Thr Leu Asp Ile Asn Leu 
1               5                   


<210>  110
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  110

Val Ile Ile Lys Gly Leu Glu Glu Ile 
1               5                   


<210>  111
<211>  317
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAGE-A4_P43358

<400>  111

Met Ser Ser Glu Gln Lys Ser Gln His Cys Lys Pro Glu Glu Gly Val 
1               5                   10                  15      


Glu Ala Gln Glu Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Thr 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Val Ser Ser Ser Ser Pro Leu Val Pro 
        35                  40                  45              


Gly Thr Leu Glu Glu Val Pro Ala Ala Glu Ser Ala Gly Pro Pro Gln 
    50                  55                  60                  


Ser Pro Gln Gly Ala Ser Ala Leu Pro Thr Thr Ile Ser Phe Thr Cys 
65                  70                  75                  80  


Trp Arg Gln Pro Asn Glu Gly Ser Ser Ser Gln Glu Glu Glu Gly Pro 
                85                  90                  95      


Ser Thr Ser Pro Asp Ala Glu Ser Leu Phe Arg Glu Ala Leu Ser Asn 
            100                 105                 110         


Lys Val Asp Glu Leu Ala His Phe Leu Leu Arg Lys Tyr Arg Ala Lys 
        115                 120                 125             


Glu Leu Val Thr Lys Ala Glu Met Leu Glu Arg Val Ile Lys Asn Tyr 
    130                 135                 140                 


Lys Arg Cys Phe Pro Val Ile Phe Gly Lys Ala Ser Glu Ser Leu Lys 
145                 150                 155                 160 


Met Ile Phe Gly Ile Asp Val Lys Glu Val Asp Pro Ala Ser Asn Thr 
                165                 170                 175     


Tyr Thr Leu Val Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly 
            180                 185                 190         


Asn Asn Gln Ile Phe Pro Lys Thr Gly Leu Leu Ile Ile Val Leu Gly 
        195                 200                 205             


Thr Ile Ala Met Glu Gly Asp Ser Ala Ser Glu Glu Glu Ile Trp Glu 
    210                 215                 220                 


Glu Leu Gly Val Met Gly Val Tyr Asp Gly Arg Glu His Thr Val Tyr 
225                 230                 235                 240 


Gly Glu Pro Arg Lys Leu Leu Thr Gln Asp Trp Val Gln Glu Asn Tyr 
                245                 250                 255     


Leu Glu Tyr Arg Gln Val Pro Gly Ser Asn Pro Ala Arg Tyr Glu Phe 
            260                 265                 270         


Leu Trp Gly Pro Arg Ala Leu Ala Glu Thr Ser Tyr Val Lys Val Leu 
        275                 280                 285             


Glu His Val Val Arg Val Asn Ala Arg Val Arg Ile Ala Tyr Pro Ser 
    290                 295                 300                 


Leu Arg Glu Ala Ala Leu Leu Glu Glu Glu Glu Gly Val 
305                 310                 315         


<210>  112
<211>  318
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MAGE-A8_P43361

<400>  112

Met Leu Leu Gly Gln Lys Ser Gln Arg Tyr Lys Ala Glu Glu Gly Leu 
1               5                   10                  15      


Gln Ala Gln Gly Glu Ala Pro Gly Leu Met Asp Val Gln Ile Pro Thr 
            20                  25                  30          


Ala Glu Glu Gln Lys Ala Ala Ser Ser Ser Ser Thr Leu Ile Met Gly 
        35                  40                  45              


Thr Leu Glu Glu Val Thr Asp Ser Gly Ser Pro Ser Pro Pro Gln Ser 
    50                  55                  60                  


Pro Glu Gly Ala Ser Ser Ser Leu Thr Val Thr Asp Ser Thr Leu Trp 
65                  70                  75                  80  


Ser Gln Ser Asp Glu Gly Ser Ser Ser Asn Glu Glu Glu Gly Pro Ser 
                85                  90                  95      


Thr Ser Pro Asp Pro Ala His Leu Glu Ser Leu Phe Arg Glu Ala Leu 
            100                 105                 110         


Asp Glu Lys Val Ala Glu Leu Val Arg Phe Leu Leu Arg Lys Tyr Gln 
        115                 120                 125             


Ile Lys Glu Pro Val Thr Lys Ala Glu Met Leu Glu Ser Val Ile Lys 
    130                 135                 140                 


Asn Tyr Lys Asn His Phe Pro Asp Ile Phe Ser Lys Ala Ser Glu Cys 
145                 150                 155                 160 


Met Gln Val Ile Phe Gly Ile Asp Val Lys Glu Val Asp Pro Ala Gly 
                165                 170                 175     


His Ser Tyr Ile Leu Val Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu 
            180                 185                 190         


Leu Gly Asp Asp Gln Ser Thr Pro Lys Thr Gly Leu Leu Ile Ile Val 
        195                 200                 205             


Leu Gly Met Ile Leu Met Glu Gly Ser Arg Ala Pro Glu Glu Ala Ile 
    210                 215                 220                 


Trp Glu Ala Leu Ser Val Met Gly Leu Tyr Asp Gly Arg Glu His Ser 
225                 230                 235                 240 


Val Tyr Trp Lys Leu Arg Lys Leu Leu Thr Gln Glu Trp Val Gln Glu 
                245                 250                 255     


Asn Tyr Leu Glu Tyr Arg Gln Ala Pro Gly Ser Asp Pro Val Arg Tyr 
            260                 265                 270         


Glu Phe Leu Trp Gly Pro Arg Ala Leu Ala Glu Thr Ser Tyr Val Lys 
        275                 280                 285             


Val Leu Glu His Val Val Arg Val Asn Ala Arg Val Arg Ile Ser Tyr 
    290                 295                 300                 


Pro Ser Leu His Glu Glu Ala Leu Gly Glu Glu Lys Gly Val 
305                 310                 315             


<210>  113
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  113

Thr Val Ala Ala Pro 
1               5   


<210>  114
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  114

Gly Gly Gly Ser 
1               


<210>  115
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  115

Gly Gly Gly Gly Ser 
1               5   


<210>  116
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  116

Thr Val Leu Arg Thr 
1               5   


<210>  117
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  117

Thr Val Ser Ser Ala Ser 
1               5       


<210>  118
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  118

Gly Gly Gly Ser Gly Gly Gly Gly 
1               5               


<210>  119
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  119

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  120
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  120

Gly Gly Gly Gly Ser Ala Ala Ala 
1               5               


<210>  121
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  121

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  122
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  122

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser 
            20                  25          


<210>  123
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  123

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  124
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  124

Thr Val Leu Ser Ser Ala Ser 
1               5           


<210>  125
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  125

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  126
<211>  232
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fc_IGHG1*01

<400>  126

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  127
<211>  21
<212>  PRT
<213>  Artificial sequence IgG1_Hinge

<220>
<223>  TAA

<400>  127

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly 
            20      


<210>  128
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IgG2_Hinge

<400>  128

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro 
            


<210>  129
<211>  53
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IgG3_Hinge

<400>  129

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala 
        35                  40                  45              


Pro Glu Leu Leu Gly 
    50              


<210>  130
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  IgG4_Hinge

<400>  130

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly 
        


<210>  131
<211>  229
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fc_knob

<400>  131

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro 
225                 


<210>  132
<211>  229
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fc_hole

<400>  132

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro 
225                 


<210>  133
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRH1_VH2,6,7,9,10,12,13,14,16,18

<400>  133

Gly Tyr Thr Met Asn 
1               5   


<210>  134
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRH1_VH8,11,15,19,20,21,22

<400>  134

Glu Tyr Thr Met Asn 
1               5   


<210>  135
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRH2_VH6

<400>  135

Leu Ile Asn Pro Tyr Lys Gly Val Thr Thr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  136
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRH2_VH7

<400>  136

Leu Ile Asn Pro Tyr Lys Gly Val Thr Thr Tyr Ala Gln Lys Val Gln 
1               5                   10                  15      


Gly 
    


<210>  137
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH2

<400>  137

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  138
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRH2_VH9,11,18,21,22

<400>  138

Leu Ile Asn Pro Gln Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  139
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRH2_VH10

<400>  139

Leu Ile Asn Pro Tyr Glu Gly Val Ser Thr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  140
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRH2_VH12

<400>  140

Leu Ile Asn Pro Glu Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  141
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRH2_VH13

<400>  141

Leu Ile Asn Pro Tyr Arg Gly Val Ser Thr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  142
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRH2_VH14, VH15

<400>  142

Leu Ile Asn Pro Gln Lys Gly Val Thr Thr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  143
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  143

Gly Gly Gln Gly Ser Gly Gly Thr Gly Ser Gly Gly Gln Gly Ser Gly 
1               5                   10                  15      


Gly Thr Gly Ser Gly Gly Gln Gly Ser 
            20                  25  


<210>  144
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRH3_VH16, VH18, VH20, VH22

<400>  144

Ser Gly Tyr Tyr Gly Glu Ser Asp Trp Tyr Phe Asp Val 
1               5                   10              


<210>  145
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VL5

<400>  145

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Gln Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  146
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HIV-005

<400>  146

Ser Leu Tyr Asn Thr Val Ala Thr Leu 
1               5                   


<210>  147
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Influenza A MP

<400>  147

Gly Ile Leu Gly Phe Val Phe Thr Leu 
1               5                   


<210>  148
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HCMV pp65

<400>  148

Asn Leu Val Pro Met Val Ala Thr Val 
1               5                   


<210>  149
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH9 = VH17

<400>  149

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Gln Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  150
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH10

<400>  150

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Glu Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  151
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH11 = VH21

<400>  151

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Gln Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  152
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH12

<400>  152

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Glu Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  153
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH13

<400>  153

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Arg Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  154
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH14

<400>  154

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Gln Lys Gly Val Thr Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  155
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH15

<400>  155

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Gln Lys Gly Val Thr Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  156
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH16

<400>  156

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Glu Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  157
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH18

<400>  157

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Gln Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Glu Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  158
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH8 = VH19

<400>  158

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  159
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH20

<400>  159

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Glu Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  160
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  VH22

<400>  160

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Gln Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Glu Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  161
<211>  315
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD3delta-FcKO

<400>  161

Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg Val Phe Val Asn Cys 
1               5                   10                  15      


Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val Gly Thr Leu Leu Ser 
            20                  25                  30          


Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile Leu Asp Pro Arg Gly 
        35                  40                  45              


Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys Asp Lys Glu Ser Thr 
    50                  55                  60                  


Val Gln Val His Tyr Arg Met Cys Gln Ser Cys Val Glu Leu Asp Pro 
65                  70                  75                  80  


Ala Thr Val Ala Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
                85                  90                  95      


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
            100                 105                 110         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        115                 120                 125             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    130                 135                 140                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
145                 150                 155                 160 


Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                165                 170                 175     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            180                 185                 190         


Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        195                 200                 205             


Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp 
    210                 215                 220                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 
225                 230                 235                 240 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                245                 250                 255     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            260                 265                 270         


Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        275                 280                 285             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    290                 295                 300                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
305                 310                 315 


<210>  162
<211>  341
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD3epsilon-FcKO

<400>  162

Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val 
1               5                   10                  15      


Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly 
            20                  25                  30          


Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
        35                  40                  45              


Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
    50                  55                  60                  


Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
65                  70                  75                  80  


Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
                85                  90                  95      


Cys Glu Asn Cys Met Glu Met Asp Glu Pro Lys Ser Ser Asp Lys Thr 
            100                 105                 110         


His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
        115                 120                 125             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    130                 135                 140                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
145                 150                 155                 160 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                165                 170                 175     


Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser 
            180                 185                 190         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        195                 200                 205             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile 
    210                 215                 220                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
225                 230                 235                 240 


Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
                245                 250                 255     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            260                 265                 270         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        275                 280                 285             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    290                 295                 300                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
305                 310                 315                 320 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His 
                325                 330                 335     


His His His His His 
            340     


<210>  163
<211>  453
<212>  PRT
<213>  Artificial sequence

<220>
<223>  114-iso1-UCHT1(VL)-Knob

<400>  163

Glu Asp Val Glu Gln Ser Leu Phe Leu Ser Val Arg Glu Gly Asp Ser 
1               5                   10                  15      


Val Val Ile Asn Cys Thr Tyr Thr Asp Ser Ser Ser Thr Tyr Leu Tyr 
            20                  25                  30          


Trp Tyr Lys Gln Glu Pro Gly Lys Gly Leu Gln Leu Leu Thr Tyr Ile 
        35                  40                  45              


Tyr Ser Ser Gln Asp Gln Lys Gln Asp Gln Arg Leu Thr Val Leu Leu 
    50                  55                  60                  


Asn Lys Lys Asp Lys His Leu Ser Leu Arg Ile Ala Asp Thr Gln Thr 
65                  70                  75                  80  


Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu Met Thr Ser Glu Ser Lys 
                85                  90                  95      


Ile Ile Phe Gly Ser Gly Thr Arg Leu Ser Ile Arg Pro Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
        115                 120                 125             


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
    130                 135                 140                 


Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
145                 150                 155                 160 


Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro 
                165                 170                 175     


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
            180                 185                 190         


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
        195                 200                 205             


Gln Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
    210                 215                 220                 


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro 
    450             


<210>  164
<211>  453
<212>  PRT
<213>  Artificial sequence

<220>
<223>  114-iso2-UCHT1(VL)-Knob

<400>  164

Glu Asp Val Glu Gln Ser Leu Phe Leu Ser Val Arg Glu Gly Asp Ser 
1               5                   10                  15      


Val Val Ile Asn Cys Thr Tyr Thr Glu Ser Ser Ser Thr Tyr Leu Tyr 
            20                  25                  30          


Trp Tyr Lys Gln Glu Pro Gly Lys Gly Leu Gln Leu Leu Thr Tyr Ile 
        35                  40                  45              


Tyr Ser Ser Gln Asp Gln Lys Gln Asp Gln Arg Leu Thr Val Leu Leu 
    50                  55                  60                  


Asn Lys Lys Asp Lys His Leu Ser Leu Arg Ile Ala Asp Thr Gln Thr 
65                  70                  75                  80  


Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu Met Thr Ser Glu Ser Lys 
                85                  90                  95      


Ile Ile Phe Gly Ser Gly Thr Arg Leu Ser Ile Arg Pro Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
        115                 120                 125             


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
    130                 135                 140                 


Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
145                 150                 155                 160 


Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro 
                165                 170                 175     


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
            180                 185                 190         


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
        195                 200                 205             


Gln Thr Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
    210                 215                 220                 


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro 
    450             


<210>  165
<211>  471
<212>  PRT
<213>  Artificial sequence

<220>
<223>  114-isoX-UCHT1(17opt)-Hole

<400>  165

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Glu Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu 
    130                 135                 140                 


Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Pro Gly His Asp 
145                 150                 155                 160 


Tyr Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu Leu 
                165                 170                 175     


Phe Tyr Phe Cys Tyr Gly Thr Pro Cys Asp Asp Ser Gly Met Pro Glu 
            180                 185                 190         


Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys 
        195                 200                 205             


Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser 
    210                 215                 220                 


Arg Ala Asp Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg Leu Thr 
225                 230                 235                 240 


Val Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro 
465                 470     


<210>  166
<211>  471
<212>  PRT
<213>  Artificial sequence

<220>
<223>  114-isoX-UCHT1(23)-Hole

<400>  166

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Gln Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu 
    130                 135                 140                 


Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Pro Gly His Asp 
145                 150                 155                 160 


Tyr Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu Leu 
                165                 170                 175     


Phe Tyr Phe Cys Tyr Gly Thr Pro Cys Asp Asp Ser Gly Met Pro Glu 
            180                 185                 190         


Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys 
        195                 200                 205             


Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser 
    210                 215                 220                 


Arg Ala Asp Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg Leu Thr 
225                 230                 235                 240 


Val Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro 
465                 470     


<210>  167
<211>  471
<212>  PRT
<213>  Artificial sequence

<220>
<223>  114-isoX-UCHT1(21)-Hole

<400>  167

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Gln Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu 
    130                 135                 140                 


Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Pro Gly His Asp 
145                 150                 155                 160 


Tyr Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu Leu 
                165                 170                 175     


Phe Tyr Phe Cys Tyr Gly Thr Pro Cys Asp Asp Ser Gly Met Pro Glu 
            180                 185                 190         


Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys 
        195                 200                 205             


Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser 
    210                 215                 220                 


Arg Ala Asp Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg Leu Thr 
225                 230                 235                 240 


Val Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro 
465                 470     


<210>  168
<211>  461
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRAME-BMA031(VL3B)-Knob

<400>  168

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys Thr 
        115                 120                 125             


Arg Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Pro Gly His Arg 
    130                 135                 140                 


Ser Val Ser Trp Tyr Arg Gln Thr Pro Gly Gln Gly Leu Gln Phe Leu 
145                 150                 155                 160 


Phe Glu Tyr Val His Gly Glu Glu Arg Asn Lys Gly Asn Phe Pro Gly 
                165                 170                 175     


Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser Ser Ser Glu Met Asn Ile 
            180                 185                 190         


Ser Asn Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser 
        195                 200                 205             


Pro Trp Asp Ser Pro Asn Val Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
    210                 215                 220                 


Thr Val Thr Glu Asp Leu Lys Asn Glu Pro Lys Ser Ser Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460     


<210>  169
<211>  474
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRAME-BMA031(VH2)-Hole

<400>  169

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Lys Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Asp Asn Asp 
                85                  90                  95      


Gln Gly Gly Ile Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn Gly Gly Gly Ser Gly Gly Gly Gly Glu Val Gln 
        115                 120                 125             


Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
    130                 135                 140                 


Val Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr Val Met His 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Tyr Ile 
                165                 170                 175     


Asn Pro Tyr Asn Asp Val Thr Lys Tyr Ala Glu Lys Phe Gln Gly Arg 
            180                 185                 190         


Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu 
        195                 200                 205             


Ser Ser Leu Arg Ser Glu Asp Thr Ala Val His Tyr Cys Ala Arg Gly 
    210                 215                 220                 


Ser Tyr Tyr Asp Tyr Asp Gly Phe Val Tyr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
465                 470                 


<210>  170
<211>  479
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRAME-UCHT1(V17)-Hole

<400>  170

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys Thr 
    130                 135                 140                 


Arg Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Pro Gly His Arg 
145                 150                 155                 160 


Ala Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe Leu 
                165                 170                 175     


Phe Glu Tyr Val His Gly Glu Glu Arg Asn Lys Gly Asn Phe Pro Gly 
            180                 185                 190         


Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser Ser Ser Glu Met Asn Ile 
        195                 200                 205             


Ser Asn Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser 
    210                 215                 220                 


Pro Trp Asp Ser Pro Asn Val Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
225                 230                 235                 240 


Thr Val Thr Glu Asp Leu Lys Asn Glu Pro Lys Ser Ser Asp Lys Thr 
                245                 250                 255     


His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475                 


<210>  171
<211>  463
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRAME-UCHT1(V17)-Knob

<400>  171

Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp Arg Gly Ser Gln Ser 
            20                  25                  30          


Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser Pro Glu Leu Ile Met 
        35                  40                  45              


Ser Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu Ile Arg Asp Ser Gln 
65                  70                  75                  80  


Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Ala Val Ile Asp Asn Asp 
                85                  90                  95      


Gln Gly Gly Ile Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile 
            100                 105                 110         


Pro Asn Ile Gln Asn Gly Gly Gly Ser Gly Gly Gly Gly Asp Ile Gln 
        115                 120                 125             


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
    130                 135                 140                 


Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp 
145                 150                 155                 160 


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Thr 
                165                 170                 175     


Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
            180                 185                 190         


Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile 
        195                 200                 205             


Ala Thr Tyr Phe Cys Gln Gln Gly Gln Thr Leu Pro Trp Thr Phe Gly 
    210                 215                 220                 


Gln Gly Thr Lys Val Glu Ile Lys Glu Pro Lys Ser Ser Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  172
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  172

Tyr Leu Glu Asp Gly Phe Ala Tyr Val 
1               5                   


<210>  173
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  173

Lys Ile Trp Glu Glu Leu Ser Val Leu Glu Val 
1               5                   10      


<210>  174
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  174

Leu Leu Ile Pro Phe Thr Ile Phe Met 
1               5                   


<210>  175
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  175

Ile Ser Leu Asp Glu Val Ala Val Ser Leu 
1               5                   10  


<210>  176
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  176

Lys Ile Ser Asp Phe Gly Leu Ala Thr Val 
1               5                   10  


<210>  177
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  177

Lys Leu Ile Gly Asn Ile His Gly Asn Glu Val 
1               5                   10      


<210>  178
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  178

Ile Leu Leu Ser Val Leu His Gln Leu 
1               5                   


<210>  179
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  179

Leu Asp Ser Glu Ala Leu Leu Thr Leu 
1               5                   


<210>  180
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  180

Val Leu Gln Glu Asn Ser Ser Asp Tyr Gln Ser Asn Leu 
1               5                   10              


<210>  181
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  181

His Leu Leu Gly Glu Gly Ala Phe Ala Gln Val 
1               5                   10      


<210>  182
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  182

Ser Leu Val Glu Asn Ile His Val Leu 
1               5                   


<210>  183
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  183

Gly Gly Gly Gly Ser Gly Thr 
1               5           


<210>  184
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  184

Ser Leu Ser Glu Lys Ser Pro Glu Val 
1               5                   


<210>  185
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  185

Ala Met Phe Pro Asp Thr Ile Pro Arg Val 
1               5                   10  


<210>  186
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  186

Phe Leu Ile Glu Asn Leu Leu Ala Ala 
1               5                   


<210>  187
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  187

Phe Thr Ala Glu Phe Leu Glu Lys Val 
1               5                   


<210>  188
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  188

Ala Leu Tyr Gly Asn Val Gln Gln Val 
1               5                   


<210>  189
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  189

Leu Phe Gln Ser Arg Ile Ala Gly Val 
1               5                   


<210>  190
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  190

Ile Leu Ala Glu Glu Pro Ile Tyr Ile Arg Val 
1               5                   10      


<210>  191
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  191

Phe Leu Leu Glu Arg Glu Gln Leu Leu 
1               5                   


<210>  192
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  192

Leu Leu Leu Pro Leu Glu Leu Ser Leu Ala 
1               5                   10  


<210>  193
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  193

Ser Leu Ala Glu Thr Ile Phe Ile Val 
1               5                   


<210>  194
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  194

Ala Ile Leu Asn Val Asp Glu Lys Asn Gln Val 
1               5                   10      


<210>  195
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  195

Arg Leu Phe Glu Glu Val Leu Gly Val 
1               5                   


<210>  196
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  196

Tyr Leu Asp Glu Val Ala Phe Met Leu 
1               5                   


<210>  197
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  197

Lys Leu Ile Asp Glu Asp Glu Pro Leu Phe Leu 
1               5                   10      


<210>  198
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  198

Lys Leu Phe Glu Lys Ser Thr Gly Leu 
1               5                   


<210>  199
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  199

Ser Leu Leu Glu Val Asn Glu Ala Ser Ser Val 
1               5                   10      


<210>  200
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  200

Gly Val Tyr Asp Gly Arg Glu His Thr Val 
1               5                   10  


<210>  201
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  201

Gly Leu Tyr Pro Val Thr Leu Val Gly Val 
1               5                   10  


<210>  202
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  202

Ala Leu Leu Ser Ser Val Ala Glu Ala 
1               5                   


<210>  203
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  203

Thr Leu Leu Glu Gly Ile Ser Arg Ala 
1               5                   


<210>  204
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  204

Ser Leu Ile Glu Glu Ser Glu Glu Leu 
1               5                   


<210>  205
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  205

Ala Leu Tyr Val Gln Ala Pro Thr Val 
1               5                   


<210>  206
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  206

Lys Leu Ile Tyr Lys Asp Leu Val Ser Val 
1               5                   10  


<210>  207
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  207

Ile Leu Gln Asp Gly Gln Phe Leu Val 
1               5                   


<210>  208
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  208

Ser Leu Leu Asp Tyr Glu Val Ser Ile 
1               5                   


<210>  209
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  209

Leu Leu Gly Asp Ser Ser Phe Phe Leu 
1               5                   


<210>  210
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  210

Val Ile Phe Glu Gly Glu Pro Met Tyr Leu 
1               5                   10  


<210>  211
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  211

Ala Leu Ser Tyr Ile Leu Pro Tyr Leu 
1               5                   


<210>  212
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  212

Phe Leu Phe Val Asp Pro Glu Leu Val 
1               5                   


<210>  213
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  213

Ser Glu Trp Gly Ser Pro His Ala Ala Val Pro 
1               5                   10      


<210>  214
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  214

Ala Leu Ser Glu Leu Glu Arg Val Leu 
1               5                   


<210>  215
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  215

Ser Leu Phe Glu Ser Leu Glu Tyr Leu 
1               5                   


<210>  216
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  216

Lys Val Leu Glu Tyr Val Ile Lys Val 
1               5                   


<210>  217
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  217

Val Leu Leu Asn Glu Ile Leu Glu Gln Val 
1               5                   10  


<210>  218
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  218

Ser Leu Leu Asn Gln Pro Lys Ala Val 
1               5                   


<210>  219
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  219

Lys Met Ser Glu Leu Gln Thr Tyr Val 
1               5                   


<210>  220
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  220

Ala Leu Leu Glu Gln Thr Gly Asp Met Ser Leu 
1               5                   10      


<210>  221
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  221

Val Ile Ile Lys Gly Leu Glu Glu Ile Thr Val 
1               5                   10      


<210>  222
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  222

Lys Gln Phe Glu Gly Thr Val Glu Ile 
1               5                   


<210>  223
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  223

Lys Leu Gln Glu Glu Ile Pro Val Leu 
1               5                   


<210>  224
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  224

Gly Leu Ala Glu Phe Gln Glu Asn Val 
1               5                   


<210>  225
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  225

Asn Val Ala Glu Ile Val Ile His Ile 
1               5                   


<210>  226
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  226

Ala Leu Ala Gly Ile Val Thr Asn Val 
1               5                   


<210>  227
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  227

Asn Leu Leu Ile Asp Asp Lys Gly Thr Ile Lys Leu 
1               5                   10          


<210>  228
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  228

Val Leu Met Gln Asp Ser Arg Leu Tyr Leu 
1               5                   10  


<210>  229
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  229

Leu Leu Trp Gly Asn Leu Pro Glu Ile 
1               5                   


<210>  230
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  230

Ser Leu Met Glu Lys Asn Gln Ser Leu 
1               5                   


<210>  231
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  231

Lys Leu Leu Ala Val Ile His Glu Leu 
1               5                   


<210>  232
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  232

Ala Leu Gly Asp Lys Phe Leu Leu Arg Val 
1               5                   10  


<210>  233
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  233

Phe Leu Met Lys Asn Ser Asp Leu Tyr Gly Ala 
1               5                   10      


<210>  234
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  234

Lys Leu Ile Asp His Gln Gly Leu Tyr Leu 
1               5                   10  


<210>  235
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  235

Gly Pro Gly Ile Phe Pro Pro Pro Pro Pro Gln Pro 
1               5                   10          


<210>  236
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  236

Ala Leu Asn Glu Ser Leu Val Glu Cys 
1               5                   


<210>  237
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  237

Gly Leu Ala Ala Leu Ala Val His Leu 
1               5                   


<210>  238
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  238

Leu Leu Leu Glu Ala Val Trp His Leu 
1               5                   


<210>  239
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  239

Ser Ile Ile Glu Tyr Leu Pro Thr Leu 
1               5                   


<210>  240
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  240

Thr Leu His Asp Gln Val His Leu Leu 
1               5                   


<210>  241
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  241

Ser Leu Leu Met Trp Ile Thr Gln Cys 
1               5                   


<210>  242
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  242

Phe Leu Leu Asp Lys Pro Gln Asp Leu Ser Ile 
1               5                   10      


<210>  243
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  243

Tyr Leu Leu Asp Met Pro Leu Trp Tyr Leu 
1               5                   10  


<210>  244
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  244

Gly Leu Leu Asp Cys Pro Ile Phe Leu 
1               5                   


<210>  245
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  245

Val Leu Ile Glu Tyr Asn Phe Ser Ile 
1               5                   


<210>  246
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  246

Thr Leu Tyr Asn Pro Glu Arg Thr Ile Thr Val 
1               5                   10      


<210>  247
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  247

Ala Val Pro Pro Pro Pro Ser Ser Val 
1               5                   


<210>  248
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  248

Lys Leu Gln Glu Glu Leu Asn Lys Val 
1               5                   


<210>  249
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  249

Lys Leu Met Asp Pro Gly Ser Leu Pro Pro Leu 
1               5                   10      


<210>  250
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  250

Ala Leu Ile Val Ser Leu Pro Tyr Leu 
1               5                   


<210>  251
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  251

Phe Leu Leu Asp Gly Ser Ala Asn Val 
1               5                   


<210>  252
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  252

Ala Leu Asp Pro Ser Gly Asn Gln Leu Ile 
1               5                   10  


<210>  253
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  253

Ile Leu Ile Lys His Leu Val Lys Val 
1               5                   


<210>  254
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  254

Val Leu Leu Asp Thr Ile Leu Gln Leu 
1               5                   


<210>  255
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  255

His Leu Ile Ala Glu Ile His Thr Ala 
1               5                   


<210>  256
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  256

Ser Met Asn Gly Gly Val Phe Ala Val 
1               5                   


<210>  257
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  257

Met Leu Ala Glu Lys Leu Leu Gln Ala 
1               5                   


<210>  258
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  258

Tyr Met Leu Asp Ile Phe His Glu Val 
1               5                   


<210>  259
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  259

Ala Leu Trp Leu Pro Thr Asp Ser Ala Thr Val 
1               5                   10      


<210>  260
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  260

Gly Leu Ala Ser Arg Ile Leu Asp Ala 
1               5                   


<210>  261
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  261

Ala Leu Ser Val Leu Arg Leu Ala Leu 
1               5                   


<210>  262
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  262

Ser Tyr Val Lys Val Leu His His Leu 
1               5                   


<210>  263
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  263

Val Tyr Leu Pro Lys Ile Pro Ser Trp 
1               5                   


<210>  264
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  264

Asn Tyr Glu Asp His Phe Pro Leu Leu 
1               5                   


<210>  265
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  265

Val Tyr Ile Ala Glu Leu Glu Lys Ile 
1               5                   


<210>  266
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  266

Val His Phe Glu Asp Thr Gly Lys Thr Leu Leu Phe 
1               5                   10          


<210>  267
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  267

Val Leu Ser Pro Phe Ile Leu Thr Leu 
1               5                   


<210>  268
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAA

<400>  268

His Leu Leu Glu Gly Ser Val Gly Val 
1               5                   


<210>  269
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RABGAP1L-001

<400>  269

Phe Leu Leu Glu Thr Val Val Arg Val 
1               5                   


<210>  270
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AXIN1-001

<400>  270

Ile Leu Asp Glu His Val Gln Arg Val 
1               5                   


<210>  271
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ANO5-001

<400>  271

Ile Val Met Glu His Val Val Phe Leu 
1               5                   


<210>  272
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPX2-001

<400>  272

Lys Ile Leu Glu Asp Val Val Gly Val 
1               5                   


<210>  273
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNE3-001

<400>  273

Lys Leu Leu Asp Leu Gln Val Arg Val 
1               5                   


<210>  274
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIA3-001

<400>  274

Lys Val Leu Asp Lys Val Phe Arg Ala 
1               5                   


<210>  275
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HERC4-001

<400>  275

Lys Val Leu Glu Ile Leu His Arg Val 
1               5                   


<210>  276
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSME2-001

<400>  276

Lys Val Leu Glu Arg Val Asn Ala Val 
1               5                   


<210>  277
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEATR5A-001

<400>  277

Lys Val Leu Glu Thr Leu Val Thr Val 
1               5                   


<210>  278
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNOT1-003

<400>  278

Lys Val Leu Gly Ile Val Val Gly Val 
1               5                   


<210>  279
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CNOT1-003

<400>  279

Ala Val Glu Glu His Val Val Ser Val 
1               5                   


<210>  280
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PITPNM3-001

<400>  280

Ser Val Leu Glu Lys Val Thr Arg Ala 
1               5                   


<210>  281
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZFC-001

<400>  281

Lys Leu Gln Glu Gln Ile His Arg Val 
1               5                   


<210>  282
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  100(D)-NB(V36)-R7P1D5#114-iso0-dsFcKO-GK (alpha-VH)

<400>  282

Glu Asp Val Glu Gln Ser Leu Phe Leu Ser Val Arg Glu Gly Asp Ser 
1               5                   10                  15      


Val Val Ile Asn Cys Thr Tyr Thr Asp Ser Ser Ser Thr Tyr Leu Tyr 
            20                  25                  30          


Trp Tyr Lys Gln Glu Pro Gly Lys Gly Leu Gln Leu Leu Thr Tyr Ile 
        35                  40                  45              


Tyr Ser Ser Gln Asp Ser Lys Gln Asp Gln Arg Leu Thr Val Leu Leu 
    50                  55                  60                  


Asn Lys Lys Asp Lys His Leu Ser Leu Arg Ile Ala Asp Thr Gln Thr 
65                  70                  75                  80  


Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu Met Thr Ser Glu Ser Lys 
                85                  90                  95      


Ile Ile Phe Gly Ser Gly Thr Arg Leu Ser Ile Arg Pro Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
        115                 120                 125             


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
    130                 135                 140                 


Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly Gln 
145                 150                 155                 160 


Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys 
                165                 170                 175     


Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser 
            180                 185                 190         


Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
        195                 200                 205             


Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe 
    210                 215                 220                 


Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys 
225                 230                 235                 240 


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val 
                245                 250                 255     


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro 
465     


<210>  283
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  100(D)-NB(V36)-R7P1D5#114-dsFcKO-GK (VL-beta)

<400>  283

Gln Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu 
        115                 120                 125             


Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Pro Gly His Asp 
    130                 135                 140                 


Tyr Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu Leu 
145                 150                 155                 160 


Phe Tyr Phe Cys Tyr Gly Thr Pro Cys Asp Asp Ser Gly Met Pro Glu 
                165                 170                 175     


Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys 
            180                 185                 190         


Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser 
        195                 200                 205             


Arg Ala Asp Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg Leu Thr 
    210                 215                 220                 


Val Leu Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro 
    450                 455 


<210>  284
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  100(D)-NB(V36)-R7P1D5#114-iso2-dsFcKO-GK (alpha-VH)

<400>  284

Glu Asp Val Glu Gln Ser Leu Phe Leu Ser Val Arg Glu Gly Asp Ser 
1               5                   10                  15      


Val Val Ile Asn Cys Thr Tyr Thr Glu Ser Ser Ser Thr Tyr Leu Tyr 
            20                  25                  30          


Trp Tyr Lys Gln Glu Pro Gly Lys Gly Leu Gln Leu Leu Thr Tyr Ile 
        35                  40                  45              


Tyr Ser Ser Gln Asp Gln Lys Gln Asp Gln Arg Leu Thr Val Leu Leu 
    50                  55                  60                  


Asn Lys Lys Asp Lys His Leu Ser Leu Arg Ile Ala Asp Thr Gln Thr 
65                  70                  75                  80  


Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu Met Thr Ser Glu Ser Lys 
                85                  90                  95      


Ile Ile Phe Gly Ser Gly Thr Arg Leu Ser Ile Arg Pro Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
        115                 120                 125             


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
    130                 135                 140                 


Lys Phe Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly Gln 
145                 150                 155                 160 


Gly Leu Glu Trp Met Gly Tyr Ile Asn Pro Tyr Asn Asp Val Thr Lys 
                165                 170                 175     


Tyr Ala Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser 
            180                 185                 190         


Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
        195                 200                 205             


Ala Val His Tyr Cys Ala Arg Gly Ser Tyr Tyr Asp Tyr Glu Gly Phe 
    210                 215                 220                 


Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys 
225                 230                 235                 240 


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val 
                245                 250                 255     


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro 
465     


<210>  285
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR-4-L

<400>  285

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  286
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  286

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Gln Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


