                         SEQUENCE LISTING

<110>  IDP DISCOVERY PHARMA S.L.
 
<120>  Melonocyte-regulating peptides

<130>  P5219PC00

<150>  EP19382674.0
<151>  2019-08-02

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide


<220>
<221>  MISC_FEATURE
<223>  the peptide comprises a linker birradical of formula (I) 
       -[(R1)a-(R2)-(R3)b]c- connecting an amino acid at position "i" 
       with an amino acid at position "i+3" or "i+7"

<220>
<221>  MISC_FEATURE
<223>  R1 and R3 are birradicals independently selected from the group 

       consisting of: (C1-C10)alkyl; (C1-C10)alkyl substituted; 

       (C2-C10)alkenyl; (C2-C10)alkenyl substituted; (C2-C10)alkynyl; 

       and (C2-C10)alkynyl substituted;

<220>
<221>  MISC_FEATURE
<223>  "(C1-C10)alkyl substituted" means (C1-C10)alkyl substituted by 

       one or more radicals selected from: halogen, (C1-C10)alkyl, OR6 

       ,NR7R8, SR9, SOR10, SO2R11 and CO2R12

<220>
<221>  MISC_FEATURE
<223>  "(C2-C10)alkenyl substituted" means (C2-C10)alkenyl substituted 

       by one or more radicals selected from: halogen, (C1-C10)alkyl, 

       OR6 ,NR7R8, SR9, SOR10, SO2R11 and CO2R12

<220>
<221>  MISC_FEATURE
<223>  "(C2-C10)alkynyl substituted" means (C2-C10)alkynyl substituted 

       by one or more radicals selected from: halogen, (C1-C10)alkyl, 

       OR6 ,NR7R8, SR9, SOR10, SO2R11 and CO2R12

<220>
<221>  MISC_FEATURE
<223>  R2 is a birradical selected from: -O-, C(=O), C(=O)NR13, C(=O)O, 
       S(=O), S(=O)2, NR14, (C1-C10)alkyl, (C2-C10)alkenyl, 
       (C2-C10)alkynyl, -NR15-NR16-, -N=N-, -S-S-, and a known ring 
       system comprising from 3 to 14 members optionally substituted

<220>
<221>  MISC_FEATURE
<223>  "a" and "b" are the same or different and are 0 or 1; and "c" is 
       comprised from 1 to 10

<220>
<221>  MISC_FEATURE
<223>  the amino acids which are connected by the linker of formula (I),
       being of formula (II)  -NH-C(R19)-C(=O)-, wherein R19 is a 
       monoradical selected from (C1-C10)alkyl, (C2-C10)alkenyl, 
       (C2-C10)alkynyl and a known ring system comprising from 3 to 14 
       

<220>
<221>  MISC_FEATURE
<223>  the C-terminal end corresponds to -C(O)R4, wherein R4 is selected
       from -OH and-NR17R18

<220>
<221>  MISC_FEATURE
<223>  the N-terminal end corresponds to -NHR5, wherein R5 is selected  
       from -H, (C1-C20)alkyl and C1-C10)alkyl substituted by one or 
       more radicals selected from the group consisting of: halogen, 
       (C1-C10)alkyl, -OR6, -NR7R8, -SR9, -SOR10, -SO2R11, and -CO2R1

<220>
<221>  MISC_FEATURE
<223>  known ring system "optionally substituted" means that the system 
       is optionally substituted by one or more radicals independently 

       selected from halogen,OH,NO2,(C1-C10)alkyl,(C1-C10)haloalkyl and 
       (C1-C10)alkyl-O-

<220>
<221>  MISC_FEATURE
<223>  R6 to R16 are radicals independently selected from H and 
       (C1-C10)alkyl

<220>
<221>  MISC_FEATURE
<223>  R17 to R18 are radicals independently selected from H, 
       (C1-C10)alkyl, and (C1-C10)alkyl substituted by one or more 
       radicals selected from the group consisting of: halogen, 
       (C1-C10)alkyl, -OR6, -NR7R8, -SR9, -SOR10, -SO2R11, and -CO2R12

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X means (Trp)m, wherein m is 0 or 1

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X means (Asn)n, wherein n is 0 or 1

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X means (Leu)p, wherein p is 0 or 1

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X means (Gln)q, wherein q is 0 or 1

<400>  1

Xaa Xaa Lys Gly Thr Ile Leu Lys Ala Ser Val Asp Tyr Ile Arg Lys 
1               5                   10                  15      


Xaa Xaa 
        


<210>  2
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<223>  the peptide comprises a linker birradical of formula (I) 
       -[(R1)a-(R2)-(R3)b]c- connecting an amino acid at position "i" 
       with an amino acid at position "i+3" or "i+7"

<220>
<221>  MISC_FEATURE
<223>  R1 and R3 are birradicals independently selected from the group 
       consisting of: (C1-C10)alkyl; (C1-C10)alkyl substituted; 
       (C2-C10)alkenyl; (C2-C10)alkenyl substituted; (C2-C10)alkynyl; 
       and (C2-C10)alkynyl substituted;

<220>
<221>  MISC_FEATURE
<223>  "(C1-C10)alkyl substituted" means (C1-C10)alkyl substituted by 
       one or more radicals selected from: halogen, (C1-C10)alkyl, 
       OR6,NR7R8, SR9, SOR10, SO2R11 and CO2R12

<220>
<221>  MISC_FEATURE
<223>  "(C2-C10)alkenyl substituted" means (C2-C10)alkenyl substituted 
       by one or more radicals selected from: halogen, (C1-C10)alkyl, 
       OR6 ,NR7R8, SR9, SOR10, SO2R11 and CO2R12

<220>
<221>  MISC_FEATURE
<223>  "(C2-C10)alkynyl substituted" means (C2-C10)alkynyl substituted 
       by one or more radicals selected from: halogen, (C1-C10)alkyl, 
       OR6 ,NR7R8, SR9, SOR10, SO2R11 and CO2R12

<220>
<221>  MISC_FEATURE
<223>  R2 is a birradical selected from: -O-, C(=O), C(=O)NR13, C(=O)O, 
       S(=O), S(=O)2, NR14, (C1-C10)alkyl, (C2-C10)alkenyl, 
       (C2-C10)alkynyl, -NR15-NR16-, -N=N-, -S-S-, and a known ring 
       system comprising from 3 to 14 members optionally substituted

<220>
<221>  MISC_FEATURE
<223>  "a" and "b" are the same or different and are 0 or 1; and "c" is 
       comprised from 1 to 10

<220>
<221>  MISC_FEATURE
<223>  the amino acids which are connected by the linker of formula (I),
       being of formula (II) -NH-C(R19)-C(=O)-, wherein R19 is a 
       monoradical selected from (C1-C10)alkyl, (C2-C10)alkenyl, 
       (C2-C10)alkynyl and a known ring system comprising from 3 to 14 
       

<220>
<221>  MISC_FEATURE
<223>  the C-terminal end corresponds to -C(O)R4, wherein R4 is selected
       from -OH and-NR17R18

<220>
<221>  MISC_FEATURE
<223>  the N-terminal end corresponds to -NHR5, wherein R5 is selected 
       from -H, (C1-C20)alkyl, and (C1-C10)alkyl substituted by one or 
       more radicals selected from the group consisting of: halogen, 
       (C1-C10)alkyl, -OR6, -NR7R8, -SR9, -SOR10, -SO2R11, and -CO2R12

<220>
<221>  MISC_FEATURE
<223>  the "known ring system" comprises from 1 to 3 rings, each one of 
       the rings being (a) saturated, partially saturated or aromatic, 
       and (b) isolated, partially or totally fused; and each member 
       being selected from CH,CH2,NH,N,SH,S,and O

<220>
<221>  MISC_FEATURE
<223>  known ring system "optionally substituted" means that the system 
       is optionally substituted by one or more radicals independently 
       selected from halogen,OH,NO2,(C1-C10)alkyl,(C1-C10)haloalkyl and 
       (C1-C10)alkyl-O-

<220>
<221>  MISC_FEATURE
<223>  R6 to R16 are radicals independently selected from H and  
       (C1-C10)alkyl

<220>
<221>  MISC_FEATURE
<223>  R17 to R18 are radicals independently selected from H,  
       (C1-C10)alkyl, and (C1-C10)alkyl substituted by one or more 
       radicals selected from the group consisting of: halogen, 
       (C1-C10)alkyl, -OR6, -NR7R8, -SR9, -SOR10, -SO2R11, and -CO2R12

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X means (Arg)mx, wherein mx is 0 or 1

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X means (Arg)nx, wherein nx is 0 or 1

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X means (Ile)px, wherein px is 0 or 1

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X means (Pro)qx, wherein qx is 0 or 1

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be any naturally occurring amino acid

<400>  2

Xaa Xaa Arg Arg Phe Asn Ile Asn Asp Arg Ile Lys Glu Leu Gly Thr 
1               5                   10                  15      


Leu Xaa Xaa 
            


<210>  3
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  the amino acid is of formula (II), the alpha carbon of this amino
       acid being connected to the alpha carbon of the amino acid at 
       position 10 by a linker "L"

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  the amino acid is of formula (II), the alpha carbon of this amino
       acid being connected to the alpha carbon of the amino acid at 
       position 3 by a linker "L"

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X means (Leu)p, wherein p is 0 or 1

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X means (Gln)q, wherein q is 0 or 1

<400>  3

Trp Asn Xaa Gly Thr Ile Leu Lys Ala Xaa Val Asp Tyr Ile Arg Lys 
1               5                   10                  15      


Xaa Xaa 
        


<210>  4
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X means (Trp)m, wherein m is 0 or 1

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X means (Asn)n, wherein n is 0 or 1

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  the amino acid is of formula (II), the alpha carbon of this amino
       acid being connected to the alpha carbon of amino acid at 
       position 14 by the linker "L

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  the amino acid is of formula (II), the alpha carbon of this amino
       acid being connected to the alpha carbon of amino acid at 
       position 7 by the linker "L

<400>  4

Xaa Xaa Lys Gly Thr Ile Xaa Lys Ala Ser Val Asp Tyr Xaa Arg Lys 
1               5                   10                  15      


Leu Gln 
        


<210>  5
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X means (Trp)m, wherein m is 0 or 1

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X means (Asn)n, wherein n is 0 or 1

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  the amino acid is of formula (II), the alpha carbon atom of this 
       amino acid being connected to the alpha carbon of the amino acid 
       at position 17 by linker "L"

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  the amino acid is of formula (II), the alpha carbon atom of this 
       amino acid being connected to the alpha carbon of the amino acid 
       at position 10 by linker "L"

<400>  5

Xaa Xaa Lys Gly Thr Ile Leu Lys Ala Xaa Val Asp Tyr Ile Arg Lys 
1               5                   10                  15      


Xaa Gln 
        


<210>  6
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  the amino acid is of formula (II), the alpha carbon of this amino
       acid being connected to the alpha carbon of amino acid at 
       position 10 by linker "L"

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  the amino acid is of formula (II), the alpha carbon of this amino
       acid being connected to the alpha carbon of amino acid at 
       position 3 by linker "L"

<400>  6

Trp Asn Xaa Gly Thr Ile Leu Lys Ala Xaa Val Asp Tyr Ile Arg Lys 
1               5                   10                  15      


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  the amino acid is of formula (II), the alpha carbon of this amino
       acid being connected to the alpha carbon of the amino acid at 
       position 12 by the linker "L"

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  the amino acid is of formula (II), the alpha carbon of this amino
       acid being connected to the alpha carbon of the amino acid at 
       position 5 by the linker "L"

<400>  7

Lys Gly Thr Ile Xaa Lys Ala Ser Val Asp Tyr Xaa Arg Lys Leu Gln 
1               5                   10                  15      


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  the amino acid is of formula (II), the alpha carbon atom of this 
       amino acid being connected to the alpha carbon of amino acid at 
       position 15 by the linker "L"

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  the amino acid is of formula (II), the alpha carbon atom of this 
       amino acid being connected to the alpha carbon of amino acid at 
       position 8 by the linker "L"

<400>  8

Lys Gly Thr Ile Leu Lys Ala Xaa Val Asp Tyr Ile Arg Lys Xaa Gln 
1               5                   10                  15      


<210>  9
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  the amino acid is of formula (II), the alpha carbon of this amino
       acid being connected to the alpha carbon of amino acid at 
       position 15 by the linker "L"

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  the amino acid is of formula (II), the alpha carbon of this amino
       acid being connected to the alpha carbon of amino acid at 
       position 8 by the linker "L"

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X means (Ile)px, wherein px is 0 or 1

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X means (Pro)qx, wherein qx is 0 or 1

<400>  9

Arg Arg Arg Arg Phe Asn Ile Xaa Asp Arg Ile Lys Glu Leu Xaa Thr 
1               5                   10                  15      


Leu Xaa Xaa 
            


<210>  10
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X means (Arg)mx, wherein mx is 0 or 1

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X means (Arg)nx, wherein nx is 0 or 1

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  the amino acid is of formula (II), the alpha carbon of this amino
       acid being connected to the alpha carbon of amino acid at 
       position 13 by the linker "L"

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  the amino acid is of formula (II), the alpha carbon of this amino
       acid being connected to the alpha carbon of amino acid at 
       position 6 by the linker "L"

<400>  10

Xaa Xaa Arg Arg Phe Xaa Ile Asn Asp Arg Ile Lys Xaa Leu Gly Thr 
1               5                   10                  15      


Leu Ile Pro 
            


<210>  11
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  the amino acid is of formula (II), the alpha carbon of this amino
       acid being connected to the alpha carbon of amino acid at 
       position 10 by the linker "L"

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  the amino acid is of formula (II), the alpha carbon of this amino
       acid being connected to the alpha carbon of amino acid at 
       position 3 by the linker "L"

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X means (Ile)px, wherein px is 0 or 1

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X means (Pro)qx, wherein qx is 0 or 1

<400>  11

Arg Arg Xaa Arg Phe Asn Ile Asn Asp Xaa Ile Lys Glu Leu Gly Thr 
1               5                   10                  15      


Leu Xaa Xaa 
            


<210>  12
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X means (Arg)mx, wherein mx is 0 or 1

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X means (Arg)nx, wherein nx is 0 or 1

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  the amino acid is of formula (II), the alpha carbon of this amino
       acid being connected to the alpha carbon of amino acid at 
       position 15 by the linker "L"

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  the amino acid is of formula (II), the alpha carbon of this amino
       acid being connected to the alpha carbon of amino acid at 
       position 8 by the linker "L"

<400>  12

Xaa Xaa Arg Arg Phe Asn Ile Xaa Asp Arg Ile Lys Glu Leu Xaa Thr 
1               5                   10                  15      


Leu Ile Pro 
            


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  the amino acid is of formula (II), the alpha carbon of this amino
       acid being connected to the alpha carbon of amino acid at 
       position 15 by the linker "L"

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  the amino acid is of formula (II), the alpha carbon of this amino
       acid being connected to the alpha carbon of amino acid at 
       position 8 by the linker "L"

<400>  13

Arg Arg Arg Arg Phe Asn Ile Xaa Asp Arg Ile Lys Glu Leu Xaa Thr 
1               5                   10                  15      


Leu 
    


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  the amino acid is of formula (II), the alpha carbon atom of this 
       amino acid being connected to the alpha carbon of amino acid at 
       position 10 by the linker "L"

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  the amino acid is of formula (II), the alpha carbon atom of this 
       amino acid being connected to the alpha carbon of amino acid at 
       position 3 by the linker "L"

<400>  14

Arg Arg Xaa Arg Phe Asn Ile Asn Asp Xaa Ile Lys Glu Leu Gly Thr 
1               5                   10                  15      


Leu 
    


<210>  15
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  the amino acid is of formula (II), the alpha carbon of this amino
       acid being connected to the alpha carbon of amino acid at 
       position 11 by the linker "L"

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  the amino acid is of formula (II), the alpha carbon of this amino
       acid being connected to the alpha carbon of amino acid at 
       position 4 by the linker "L"

<400>  15

Arg Arg Phe Xaa Ile Asn Asp Arg Ile Lys Xaa Leu Gly Thr Leu Ile 
1               5                   10                  15      


Pro 
    


<210>  16
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  the amino acid is of formula (II), the alpha carbon of this amino
       acid being connected to the alpha carbon of amino acid at 
       position 13 by the linker "L"

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  the amino acid is of formula (II), the alpha carbon of this amino
       acid being connected to the alpha carbon of amino acid at 
       position 6 by the linker "L"

<400>  16

Arg Arg Phe Asn Ile Xaa Asp Arg Ile Lys Glu Leu Xaa Thr Leu Ile 
1               5                   10                  15      


Pro 
    


<210>  17
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  the amino acid is of formula (II), being R19 a -CH3 radical; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 10 by the linker  
       -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  the amino acid is of formula (II), being R19 a -CH3 radical; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 3 by the linker  
       -(CH2)6-CH=CH-(CH2)3-

<400>  17

Trp Asn Xaa Gly Thr Ile Leu Lys Ala Xaa Val Asp Tyr Ile Arg Lys 
1               5                   10                  15      


<210>  18
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  the amino acid is of formula (II) being R19 a -CH3 radical; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 12 by the linker  
       -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  the amino acid is of formula (II) being R19 a -CH3 radical; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 5 by the linker  
       -(CH2)6-CH=CH-(CH2)3-

<400>  18

Lys Gly Thr Ile Xaa Lys Ala Ser Val Asp Tyr Xaa Arg Lys Leu Gln 
1               5                   10                  15      


<210>  19
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  the amino acid is of formula (II) being R19 a -CH3 radical; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 15 by the linker  
       -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  the amino acid is of formula (II) being R19 a -CH3 radical; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 8 by the linker  
       -(CH2)6-CH=CH-(CH2)3-

<400>  19

Lys Gly Thr Ile Leu Lys Ala Xaa Val Asp Tyr Ile Arg Lys Xaa Gln 
1               5                   10                  15      


<210>  20
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  the amino acid is of formula (II), being R19 a -CH3 radical; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 15 by the linker  
       -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  the amino acid is of formula (II), being R19 a -CH3 radical; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid at position 8 by the linker  
       -(CH2)6-CH=CH-(CH2)3-

<400>  20

Arg Arg Arg Arg Phe Asn Ile Xaa Asp Arg Ile Lys Glu Leu Xaa Thr 
1               5                   10                  15      


Leu 
    


<210>  21
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  the amino acid is of formula (II), being R19 a -CH3 radical; the 
       alpha carbon of this amino acid is connected to the alpha carbon 
       of amino acid at position 10 by the linker  -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  the amino acid is of formula (II), being R19 a -CH3 radical; the 
       alpha carbon of this amino acid is connected to the alpha carbon 
       of amino acid at position 4 by the linker  -(CH2)6-CH=CH-(CH2)3-

<400>  21

Arg Arg Xaa Arg Phe Asn Ile Asn Asp Xaa Ile Lys Glu Leu Gly Thr 
1               5                   10                  15      


Leu 
    


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  the amino acid is of formula (II), being R19 a -CH3 radical; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid  at position 11 by the linker  
       -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  the amino acid is of formula (II), being R19 a -CH3 radical; the 
       alpha carbon of this amino acid being connected to the alpha 
       carbon of amino acid  at position 4 by the linker  
       -(CH2)6-CH=CH-(CH2)3-

<400>  22

Arg Arg Phe Xaa Ile Asn Asp Arg Ile Lys Xaa Leu Gly Thr Leu Ile 
1               5                   10                  15      


Pro 
    


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  the amino acid is of formula (II), being R19 a -CH3 radical; the 
       alpha carbon of this amino acid is connected to the alpha carbon 
       of amino acid at position 13 by the linker  -(CH2)6-CH=CH-(CH2)3-

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  the amino acid is of formula (II), being R19 a -CH3 radical; the 
       alpha carbon of this amino acid is connected to the alpha carbon 
       of amino acid at position 6 by the linker  -(CH2)6-CH=CH-(CH2)3-

<400>  23

Arg Arg Phe Asn Ile Xaa Asp Arg Ile Lys Glu Leu Xaa Thr Leu Ile 
1               5                   10                  15      


Pro 
    


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  24

Trp Asn Lys Gly Thr Ile Leu Lys Ala Ser Val Asp Tyr Ile Arg Lys 
1               5                   10                  15      


<210>  25
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  25

Asn Lys Gly Thr Ile Leu Lys Ala Ser Val Asp Tyr Ile Arg Lys Leu 
1               5                   10                  15      


<210>  26
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  26

Lys Gly Thr Ile Leu Lys Ala Ser Val Asp Tyr Ile Arg Lys Leu Gln 
1               5                   10                  15      


