               SEQUENCE LISTING

<110> OREGA BIOTECH

<120> NOVEL IL-17B ANTIBODIES

<130> O57-B-57434 PCT

<150> EP19306004.3
<151> 2019-08-02

<160> 71

<170> BiSSAP 1.3.6

<210> 1
<211> 180
<212> PRT
<213> Homo sapiens


<220> 
<223> human IL-17B (Propeptide)

<400> 1
Met Asp Trp Pro His Asn Leu Leu Phe Leu Leu Thr Ile Ser Ile Phe 
1               5                   10                  15      
Leu Gly Leu Gly Gln Pro Arg Ser Pro Lys Ser Lys Arg Lys Gly Gln 
            20                  25                  30          
Gly Arg Pro Gly Pro Leu Ala Pro Gly Pro His Gln Val Pro Leu Asp 
        35                  40                  45              
Leu Val Ser Arg Met Lys Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg 
    50                  55                  60                  
Asn Ile Glu Glu Met Val Ala Gln Leu Arg Asn Ser Ser Glu Leu Ala 
65                  70                  75                  80  
Gln Arg Lys Cys Glu Val Asn Leu Gln Leu Trp Met Ser Asn Lys Arg 
                85                  90                  95      
Ser Leu Ser Pro Trp Gly Tyr Ser Ile Asn His Asp Pro Ser Arg Ile 
            100                 105                 110         
Pro Val Asp Leu Pro Glu Ala Arg Cys Leu Cys Leu Gly Cys Val Asn 
        115                 120                 125             
Pro Phe Thr Met Gln Glu Asp Arg Ser Met Val Ser Val Pro Val Phe 
    130                 135                 140                 
Ser Gln Val Pro Val Arg Arg Arg Leu Cys Pro Pro Pro Pro Arg Thr 
145                 150                 155                 160 
Gly Pro Cys Arg Gln Arg Ala Val Met Glu Thr Ile Ala Val Gly Cys 
                165                 170                 175     
Thr Cys Ile Phe 
            180 

<210> 2
<211> 160
<212> PRT
<213> Homo sapiens


<220> 
<223> Human IL-17B (Peptide)

<400> 2
Gln Pro Arg Ser Pro Lys Ser Lys Arg Lys Gly Gln Gly Arg Pro Gly 
1               5                   10                  15      
Pro Leu Ala Pro Gly Pro His Gln Val Pro Leu Asp Leu Val Ser Arg 
            20                  25                  30          
Met Lys Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg Asn Ile Glu Glu 
        35                  40                  45              
Met Val Ala Gln Leu Arg Asn Ser Ser Glu Leu Ala Gln Arg Lys Cys 
    50                  55                  60                  
Glu Val Asn Leu Gln Leu Trp Met Ser Asn Lys Arg Ser Leu Ser Pro 
65                  70                  75                  80  
Trp Gly Tyr Ser Ile Asn His Asp Pro Ser Arg Ile Pro Val Asp Leu 
                85                  90                  95      
Pro Glu Ala Arg Cys Leu Cys Leu Gly Cys Val Asn Pro Phe Thr Met 
            100                 105                 110         
Gln Glu Asp Arg Ser Met Val Ser Val Pro Val Phe Ser Gln Val Pro 
        115                 120                 125             
Val Arg Arg Arg Leu Cys Pro Pro Pro Pro Arg Thr Gly Pro Cys Arg 
    130                 135                 140                 
Gln Arg Ala Val Met Glu Thr Ile Ala Val Gly Cys Thr Cys Ile Phe 
145                 150                 155                 160 



<210> 3
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Epitope 44-52

<400> 3
Gln Val Pro Leu Asp Leu Val Ser Arg 
1               5                   

<210> 4
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Epitope 145-152

<400> 4
Ser Gln Val Pro Val Arg Arg Arg 
1               5               

<210> 5
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Epitope 155-165

<400> 5
Pro Pro Pro Pro Arg Thr Gly Pro Cys Arg Gln 
1               5                   10      

<210> 6
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Epitope 84-93

<400> 6
Cys Glu Val Asn Leu Gln Leu Trp Met Ser 
1               5                   10  

<210> 7
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Epitope 54-62

<400> 7
Lys Pro Tyr Ala Arg Met Glu Glu Tyr 
1               5                   

<210> 8
<211> 138
<212> PRT
<213> Artificial Sequence


<220> 
<223> 12F9 VH

<400> 8
Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      
Val His Cys Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Thr Asp Tyr Phe Ile Asn Trp Val Arg Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Ile Gly Trp Ile Phe Pro Gly Ser Gly Ser Thr Tyr Tyr His 
65                  70                  75                  80  
Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      
Thr Ala Tyr Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         
Tyr Phe Cys Ala Arg Thr Leu Tyr Gly Asn Trp Tyr Phe Asp Val Trp 
        115                 120                 125             
Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
    130                 135             

<210> 9
<211> 131
<212> PRT
<213> Artificial Sequence


<220> 
<223> 12F9 VL

<400> 9
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      
Ser Ser Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          
Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile 
        35                  40                  45              
Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  
Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      
Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         
Phe Gln Gly Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             
Glu Ile Lys 
    130     

<210> 10
<211> 414
<212> DNA
<213> Artificial Sequence


<220> 
<223> 12F9 VH

<400> 10
atgggatgga gctggatctt tctcttcctc ctgtcaggaa ctgcaggtgt ccattgccag      60

gtccagctac agcagtctgg acctgagctg gtgaagcctg gggcttcagt gaagatatcc     120

tgcaaggctt ctggctacac cttcactgac tactttataa actgggtgag gcagaggcct     180

ggacagggac ttgagtggat tggatggatt tttcctggaa gtggtagtac ttactaccat     240

gagaagttca agggcaaggc cacacttact gtagacaaat cctccagcac agcctacatg     300

ttgctcagca gcctgacctc tgaggactct gcggtctatt tctgtgcaag aacgctctat     360

ggtaactggt acttcgatgt ctggggcaca gggaccacgg tcaccgtctc ctca           414


<210> 11
<211> 393
<212> DNA
<213> Artificial Sequence


<220> 
<223> 12F9 VL

<400> 11
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat      60

gttttgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc     120

tcttgcagat ctagtcagag cattgtacat agtaatggaa acacctattt agaatggtac     180

ctgcagaaac caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct     240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc     300

agagtggagg ctgaggatct gggagtttat tactgctttc aaggttcaca tgttccgtac     360

acgttcggag gggggaccaa gctggaaata aaa                                  393


<210> 12
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> 12F9 VH CDR1

<400> 12
Asp Tyr Phe Ile Asn 
1               5   

<210> 13
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> 12F9 VH CDR2

<400> 13
Trp Ile Phe Pro Gly Ser Gly Ser Thr Tyr Tyr His Glu Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 14
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> 12F9 VH CDR3

<400> 14
Thr Leu Tyr Gly Asn Trp Tyr Phe Asp Val 
1               5                   10  

<210> 15
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> 12F9 VL CDR1

<400> 15
Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      



<210> 16
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> 12F9 VL CDR2

<400> 16
Lys Val Ser Asn Arg Phe Ser 
1               5           

<210> 17
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> 12F9 VL CDR3

<400> 17
Phe Gln Gly Ser His Val Pro Tyr Thr 
1               5                   

<210> 18
<211> 15
<212> DNA
<213> Artificial Sequence


<220> 
<223> 12F9 VH CDR1

<400> 18
gactacttta taaac                                                     15


<210> 19
<211> 51
<212> DNA
<213> Artificial Sequence


<220> 
<223> 12F9 VH CDR2

<400> 19
tggatttttc ctggaagtgg tagtacttac taccatgaga agttcaaggg c              51


<210> 20
<211> 30
<212> DNA
<213> Artificial Sequence


<220> 
<223> 12F9 VH CDR3

<400> 20
acgctctatg gtaactggta cttcgatgtc                                     30


<210> 21
<211> 48
<212> DNA
<213> Artificial Sequence


<220> 
<223> 12F9 VL CDR1

<400> 21
agatctagtc agagcattgt acatagtaat ggaaacacct atttagaa                  48


<210> 22
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> 12F9 VL CDR2

<400> 22
aaagtttcca accgattttc t                                              21


<210> 23
<211> 27
<212> DNA
<213> Artificial Sequence


<220> 
<223> 12F9 VL CDR3

<400> 23
tttcaaggtt cacatgttcc gtacacg                                        27


<210> 24
<211> 137
<212> PRT
<213> Artificial Sequence


<220> 
<223> 13H5 VH

<400> 24
Met Gly Arg Leu Thr Ser Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      
Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          
Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              
Ser Thr Phe Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  
Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr 
65                  70                  75                  80  
Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys 
                85                  90                  95      
Asn Gln Val Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala 
            100                 105                 110         
Thr Tyr Tyr Cys Ala Arg Met Asn Asp Gly Tyr Leu Tyr Tyr Trp Gly 
        115                 120                 125             
Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135         

<210> 25
<211> 128
<212> PRT
<213> Artificial Sequence


<220> 
<223> 13H5 VL

<400> 25
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      
Val Ile Leu Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          
Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
        35                  40                  45              
Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  
Pro Arg Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  
Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      
Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         
Ser Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             



<210> 26
<211> 411
<212> DNA
<213> Artificial Sequence


<220> 
<223> 13H5 VH

<400> 26
atgggcaggc ttacttcttc attcctgtta ctgattgtcc ctgcatatgt cctgtcccag      60

gttactctga aagagtctgg ccctgggata ttgcagccct cccagaccct cagtctgact     120

tgttctttct ctgggttttc actgagcact tttggtatgg gtgtaggctg gattcgtcag     180

ccttcaggga agggtctgga gtggctggca cacatttggt gggatgatga taagtactat     240

aacccagccc tgaagagtcg gctcacaatc tccaaggata cctccaaaaa ccaggtattc     300

ctcaagatcg ccaatgtgga cactgcagat actgccacat actactgtgc tcgaatgaat     360

gatggttacc tatactactg gggtcaagga acctcagtca ccgtctcctc a              411


<210> 27
<211> 384
<212> DNA
<213> Artificial Sequence


<220> 
<223> 13H5 VL

<400> 27
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcctcagt catactgtcc      60

agaggacaaa ttgttctcac ccagtctcca gcaatcatgt ctgcatctcc aggggagaag     120

gtcaccatga cctgcagtgc cagctcaagt gtaagttaca tgtactggta ccagcagaag     180

ccaggatcct cccccagact cctgatttat gacacatcca acctggcttc tggagtccct     240

gttcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag ccgaatggag     300

gctgaagatg ctgccactta ttactgccag cagtggagta gttacccatt cacgttcggc     360

tcggggacaa agttggaaat aaaa                                            384


<210> 28
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> 13H5 VH CDR1

<400> 28
Thr Phe Gly Met Gly Val Gly 
1               5           

<210> 29
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> 13H5 VH CDR2

<400> 29
His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala Leu Lys Ser 
1               5                   10                  15      



<210> 30
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> 13H5 VH CDR3

<400> 30
Met Asn Asp Gly Tyr Leu Tyr Tyr 
1               5               

<210> 31
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> 13H5 VL CDR1

<400> 31
Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  

<210> 32
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> 13H5 VL CDR2

<400> 32
Asp Thr Ser Asn Leu Ala Ser 
1               5           

<210> 33
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> 13H5 VL CDR3

<400> 33
Gln Gln Trp Ser Ser Tyr Pro Phe Thr 
1               5                   

<210> 34
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> 13H5 VH CDR1

<400> 34
acttttggta tgggtgtagg c                                              21


<210> 35
<211> 48
<212> DNA
<213> Artificial Sequence


<220> 
<223> 13H5 VH CDR2

<400> 35
cacatttggt gggatgatga taagtactat aacccagccc tgaagagt                  48


<210> 36
<211> 24
<212> DNA
<213> Artificial Sequence


<220> 
<223> 13H5 VH CDR3

<400> 36
atgaatgatg gttacctata ctac                                           24


<210> 37
<211> 30
<212> DNA
<213> Artificial Sequence


<220> 
<223> 13H5 VL CDR1

<400> 37
agtgccagct caagtgtaag ttacatgtac                                     30


<210> 38
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> 13H5 VL CDR2

<400> 38
gacacatcca acctggcttc t                                              21


<210> 39
<211> 27
<212> DNA
<213> Artificial Sequence


<220> 
<223> 13H5 VL CDR3

<400> 39
cagcagtgga gtagttaccc attcacg                                        27


<210> 40
<211> 136
<212> PRT
<213> Artificial Sequence


<220> 
<223> 21H6 VH

<400> 40
Met Gly Arg Leu Thr Ser Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      
Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          
Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              
Ser Thr Phe Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  
Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr 
65                  70                  75                  80  
Asn Pro Ala Leu Lys Gly Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys 
                85                  90                  95      
Asn Gln Val Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Thr Ala 
            100                 105                 110         
Thr Tyr Phe Cys Ala Arg Ile Glu Asp Ala Leu Asp Tyr Trp Gly Gln 
        115                 120                 125             
Gly Thr Ser Val Thr Val Ser Ser 
    130                 135     

<210> 41
<211> 127
<212> PRT
<213> Artificial Sequence


<220> 
<223> 21H6 VL

<400> 41
Met Val Ser Thr Ser Gln Leu Leu Gly Leu Leu Leu Phe Trp Thr Ser 
1               5                   10                  15      
Ala Ser Arg Cys Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          
Val Thr Pro Gly Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Asn 
        35                  40                  45              
Ile Ser Asp Tyr Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro 
    50                  55                  60                  
Arg Leu Leu Ile Lys Tyr Thr Ser Gln Ser Ile Ser Gly Ile Pro Ser 
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn 
                85                  90                  95      
Ser Val Glu Pro Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His 
            100                 105                 110         
Ser Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         

<210> 42
<211> 408
<212> DNA
<213> Artificial Sequence


<220> 
<223> 21H6 VH

<400> 42
atgggcaggc ttacttcttc attcctgtta ctgattgtcc ctgcatatgt cctgtcccag      60

gttactctga aagagtctgg ccctgggata ttgcagccct cccagaccct cagtctgact     120

tgttctttct ctgggttttc actgagcact tttggtatgg gtgtaggctg gattcgtcag     180

ccttcaggga agggtctgga gtggctggca cacatttggt gggatgatga taagtactat     240

aacccagccc tgaagggtcg gctcacaatc tccaaggata cctccaaaaa ccaggtattc     300

ctcaagatcg ccaatgtgga cactgcagat actgccacat acttctgtgc tcgaatagaa     360

gatgctttgg actactgggg tcaaggaacc tcagtcaccg tctcctca                  408


<210> 43
<211> 381
<212> DNA
<213> Artificial Sequence


<220> 
<223> 21H6 VL

<400> 43
atggtgtcca cttctcagct ccttggactt ttgcttttct ggacttcagc ctccagatgt      60

gacattgtga tgactcagtc tccagccacc ctgtctgtga ctccaggaga tagagtctct     120

ctttcctgca gggccagcca gaatattagc gactacttac actggtatca gcaaaaatca     180

catgagtctc caaggcttct catcaaatat acttcccaat ccatctctgg gatcccctcc     240

aggttcagtg gcagtggatc agggtcagat ttcactctca gtatcaacag tgtggaacct     300

gaagatgttg gagtgtatta ctgtcaaaat ggtcacagct ttccattcac gttcggctcg     360

gggacaaagt tggaaataaa a                                               381


<210> 44
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> 21H6 VH CDR1

<400> 44
Thr Phe Gly Met Gly Val Gly 
1               5           

<210> 45
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> 21H6 VH CDR2

<400> 45
His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ala Leu Lys Gly 
1               5                   10                  15      



<210> 46
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> 21H6 VH CDR3

<400> 46
Ile Glu Asp Ala Leu Asp Tyr 
1               5           

<210> 47
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> 21H6 VL CDR1

<400> 47
Arg Ala Ser Gln Asn Ile Ser Asp Tyr Leu His 
1               5                   10      

<210> 48
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> 21H6 VL CDR2

<400> 48
Tyr Thr Ser Gln Ser Ile Ser 
1               5           

<210> 49
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> 21H6 VL CDR3

<400> 49
Gln Asn Gly His Ser Phe Pro Phe Thr 
1               5                   

<210> 50
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> 21H6 VH CDR1

<400> 50
acttttggta tgggtgtagg c                                              21


<210> 51
<211> 48
<212> DNA
<213> Artificial Sequence


<220> 
<223> 21H6 VH CDR2

<400> 51
cacatttggt gggatgatga taagtactat aacccagccc tgaagggt                  48


<210> 52
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> 21H6 VH CDR3

<400> 52
atagaagatg ctttggacta c                                              21


<210> 53
<211> 33
<212> DNA
<213> Artificial Sequence


<220> 
<223> 21H6 VL CDR1

<400> 53
agggccagcc agaatattag cgactactta cac                                  33


<210> 54
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> 21H6 VL CDR2

<400> 54
tatacttccc aatccatctc t                                              21


<210> 55
<211> 27
<212> DNA
<213> Artificial Sequence


<220> 
<223> 21H6 VL CDR3

<400> 55
caaaatggtc acagctttcc attcacg                                        27


<210> 56
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> 18G9 VH

<400> 56
Gln Ile Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          
Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Ser Gln Leu Thr Ile Ser Lys Asp Thr Ser Arg Asn Gln Val 
65                  70                  75                  80  
Phe Leu Arg Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Arg Thr Gln Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Thr Leu Thr Val Ser Ser 
        115             



<210> 57
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> 18G9 VL

<400> 57
Asp Ile Leu Met Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          
Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      
Glu Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     

<210> 58
<211> 354
<212> DNA
<213> Artificial Sequence


<220> 
<223> 18G9 VH

<400> 58
caaattactc taaaagagtc tggccctggg atattgaagc cctcacagac cctcagtctg      60

acttgttctt tctctgggtt ttcactgagc acttctggta tgggtgtagg ctggattcgt     120

cagccttcag ggaagggtct ggaatggctg gcacacattt ggtgggatga tgataagtac     180

tataacccat ccctgaagag ccagctcaca atctccaagg atacctccag aaaccaggta     240

ttcctcagga tcaccagtgt ggacactgca gatactgcca cttactactg tgctcgaaga     300

actcaggggt actttgacta ctggggccaa ggcaccactc tcacagtctc ctca           354


<210> 59
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> 18G9 VL

<400> 59
gacatcctga tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc      60

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttatat gaactggtac     120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa tctagaatct     180

gggatcccag ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat     240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc aaagtaatga ggatcctctc     300

acgttcggtg ctgggaccaa gctggagctg aaa                                  333


<210> 60
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> 18G9 VH CDR1

<400> 60
Thr Ser Gly Met Gly Val Gly 
1               5           

<210> 61
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> 18G9 VH CDR2

<400> 61
His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      



<210> 62
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> 18G9 VH CDR3

<400> 62
Arg Thr Gln Gly Tyr Phe Asp Tyr 
1               5               


<210> 63
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> 18G9 VL CDR1

<400> 63
Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn 
1               5                   10                  15  

<210> 64
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> 18G9 VL CDR2

<400> 64
Ala Ala Ser Asn Leu Glu Ser 
1               5           

<210> 65
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> 18G9 VL CDR3

<400> 65
Gln Gln Ser Asn Glu Asp Pro Leu Thr 
1               5                   

<210> 66
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> 18G9 VH CDR1

<400> 66
acttctggta tgggtgtagg c                                              21


<210> 67
<211> 48
<212> DNA
<213> Artificial Sequence


<220> 
<223> 18G9 VH CDR2

<400> 67
cacatttggt gggatgatga taagtactat aacccatccc tgaagagc                  48


<210> 68
<211> 24
<212> DNA
<213> Artificial Sequence


<220> 
<223> 18G9 VH CDR3

<400> 68
agaactcagg ggtactttga ctac                                           24



<210> 69
<211> 45
<212> DNA
<213> Artificial Sequence


<220> 
<223> 18G9 VL CDR1

<400> 69
aaggccagcc aaagtgttga ttatgatggt gatagttata tgaac                     45


<210> 70
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> 18G9 VL CDR2

<400> 70
gctgcatcca atctagaatc t                                              21


<210> 71
<211> 27
<212> DNA
<213> Artificial Sequence


<220> 
<223> 18G9 VL CDR3

<400> 71
cagcaaagta atgaggatcc tctcacg                                        27


