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<110>  江苏先声药业有限公司；先声生物医药科技有限公司
 
<120>  抗TNFR2抗体及其用途

<130>  OP201036

<160>  154   

<170>  PatentIn version 3.3

<210>  1
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 1的重链可变区

<400>  1

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Asn Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Leu Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asn Asn Gly Gly Ile Ser Thr Tyr Tyr Ser Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Pro Phe Tyr Gly Ser Ala Asn Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  2
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 1的轻链可变区

<400>  2

Glu Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Thr Ser Glu Ser Ile Tyr Ser Asn 
            20                  25                  30          


Leu Pro Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asp Ala Thr Lys Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp Val Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  3
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 88的重链可变区

<400>  3

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Asn Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Thr Tyr 
            20                  25                  30          


Asp Leu Ser Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asn Asn Gly Gly Ile Ser Thr Tyr Tyr Ser Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Thr Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Pro Phe Tyr Gly Ser Ala Asn Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  4
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 88的轻链可变区

<400>  4

Asp Ile Leu Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Phe Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asp Ala Thr Lys Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp Val Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  5
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 125的重链可变区

<400>  5

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Asn Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ile Tyr 
            20                  25                  30          


Asp Leu Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asn Asn Gly Gly Ile Ser Thr Tyr Tyr Ser Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Pro Phe Tyr Gly Ser Ala Asn Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  6
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 125的轻链可变区

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asp Ala Thr Lys Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His Phe Trp Val Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  7
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 133的重链可变区

<400>  7

Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Ile Gln Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Ser Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ala Tyr Tyr Asp Tyr Asp Gly Ser Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  8
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 133的轻链可变区

<400>  8

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Thr Asp Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Thr Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  9
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 219的重链可变区

<400>  9

Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Asp Thr Glu Thr Arg Leu Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ser Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Glu Gly Leu Gly Ala Ala Arg Ser Val Ser Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  10
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 219的轻链可变区

<400>  10

Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Val Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ala Ile Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  11
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 224的重链可变区

<400>  11

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Ile Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Asn Lys Asp Ile 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Thr Gly Asn Thr Lys His Asp Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Leu Ser Ser Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala His Ser Pro Tyr Gly Asp Phe Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  12
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 224的轻链可变区

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Pro Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  13
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 226的重链可变区

<400>  13

Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Glu Gly Leu Gly Ala Ala Arg Ser Val Ser Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  14
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 226的轻链可变区

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Val Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ala Leu Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  15
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 309的重链可变区

<400>  15

Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Leu Arg Pro Gly Gln Gly Phe Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asn Asn Gly Gly Thr Asp Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Arg Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Asp Ser Met Ile Thr Thr Thr Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  16
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 309的轻链可变区

<400>  16

Glu Ile Val Met Thr Gln Ser Gln Lys Leu Met Ser Thr Val Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Asn Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  17
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 352的重链可变区

<400>  17

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Val Val Ile Trp Ser Asp Gly Gly Thr Thr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Asp Asp Asp Gly Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  18
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 352的轻链可变区

<400>  18

Asp Ile Val Leu Thr Gln Ser Pro Ser Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Val Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asp Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  19
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 365的重链可变区

<400>  19

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Leu Ile Trp Ser Asp Gly Ser Pro Asp Tyr Ser Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Asp Asp Gly Gly Asp Tyr Val Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  20
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 365的轻链可变区

<400>  20

Glu Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  21
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 395的重链可变区

<400>  21

Glu Val Gln Leu Gln Glu Ser Gly Pro Val Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Ser Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Asp Gly Gly Thr Asp Tyr Ser Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Asp Asp Gly Gly Asp Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  22
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 395的轻链可变区

<400>  22

Glu Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  23
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 1经KABAT分析的CDR1-VH

<400>  23

Thr Tyr Asp Leu Ser 
1               5   


<210>  24
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 1经KABAT分析的CDR2-VH

<400>  24

Tyr Ile Asn Asn Gly Gly Ile Ser Thr Tyr Tyr Ser Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 1经KABAT分析的CDR3-VH

<400>  25

Gly Pro Phe Tyr Gly Ser Ala Asn Tyr Phe Asp Tyr 
1               5                   10          


<210>  26
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 1经IMGT分析的CDR1-VH

<400>  26

Gly Phe Ala Phe Ser Thr Tyr Asp 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 1经IMGT分析的CDR2-VH

<400>  27

Ile Asn Asn Gly Gly Ile Ser Thr 
1               5               


<210>  28
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 1经IMGT分析的CDR3-VH

<400>  28

Val Arg Gly Pro Phe Tyr Gly Ser Ala Asn Tyr Phe Asp Tyr 
1               5                   10                  


<210>  29
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 1经KABAT分析的CDR1-VL

<400>  29

Arg Thr Ser Glu Ser Ile Tyr Ser Asn Leu Pro 
1               5                   10      


<210>  30
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 1经KABAT分析的CDR2-VL

<400>  30

Asp Ala Thr Lys Leu Ala Glu 
1               5           


<210>  31
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 1经KABAT分析的CDR3-VL

<400>  31

Gln His Phe Trp Val Thr Pro Trp Thr 
1               5                   


<210>  32
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 1经IMGT分析的CDR1-VL

<400>  32

Glu Ser Ile Tyr Ser Asn 
1               5       


<210>  33
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 1经IMGT分析的CDR2-VL

<400>  33

Asp Ala Thr 
1           


<210>  34
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 1经IMGT分析的CDR3-VL

<400>  34

Gln His Phe Trp Val Thr Pro Trp Thr 
1               5                   


<210>  35
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 88经KABAT分析的CDR1-VH

<400>  35

Thr Tyr Asp Leu Ser 
1               5   


<210>  36
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 88经KABAT分析的CDR2-VH

<400>  36

Tyr Ile Asn Asn Gly Gly Ile Ser Thr Tyr Tyr Ser Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  37
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 88经KABAT分析的CDR3-VH

<400>  37

Gly Pro Phe Tyr Gly Ser Ala Asn Tyr Phe Asp Tyr 
1               5                   10          


<210>  38
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 88经IMGT分析的CDR1-VH

<400>  38

Gly Phe Ala Phe Ser Thr Tyr Asp 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 88经IMGT分析的CDR2-VH

<400>  39

Ile Asn Asn Gly Gly Ile Ser Thr 
1               5               


<210>  40
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 88经IMGT分析的CDR3-VH

<400>  40

Val Arg Gly Pro Phe Tyr Gly Ser Ala Asn Tyr Phe Asp Tyr 
1               5                   10                  


<210>  41
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 88经KABAT分析的CDR1-VL

<400>  41

Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  42
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 88经KABAT分析的CDR2-VL

<400>  42

Asp Ala Thr Lys Leu Ala Glu 
1               5           


<210>  43
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 88经KABAT分析的CDR3-VL

<400>  43

Gln His Phe Trp Val Thr Pro Trp Thr 
1               5                   


<210>  44
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 88经IMGT分析的CDR1-VL

<400>  44

Glu Asn Ile Tyr Ser Asn 
1               5       


<210>  45
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 88经IMGT分析的CDR2-VL

<400>  45

Asp Ala Thr 
1           


<210>  46
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 88经IMGT分析的CDR3-VL

<400>  46

Gln His Phe Trp Val Thr Pro Trp Thr 
1               5                   


<210>  47
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 125经KABAT分析的CDR1-VH

<400>  47

Ile Tyr Asp Leu Ser 
1               5   


<210>  48
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 125经KABAT分析的CDR2-VH

<400>  48

Tyr Ile Asn Asn Gly Gly Ile Ser Thr Tyr Tyr Ser Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  49
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 125经KABAT分析的CDR3-VH

<400>  49

Gly Pro Phe Tyr Gly Ser Ala Asn Tyr Phe Asp Tyr 
1               5                   10          


<210>  50
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 125经IMGT分析的CDR1-VH

<400>  50

Gly Phe Ala Phe Ser Ile Tyr Asp 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 125经IMGT分析的CDR2-VH

<400>  51

Ile Asn Asn Gly Gly Ile Ser Thr 
1               5               


<210>  52
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 125经IMGT分析的CDR3-VH

<400>  52

Val Arg Gly Pro Phe Tyr Gly Ser Ala Asn Tyr Phe Asp Tyr 
1               5                   10                  


<210>  53
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 125经KABAT分析的CDR1-VL

<400>  53

Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  54
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 125经KABAT分析的CDR2-VL

<400>  54

Asp Ala Thr Lys Leu Ala Glu 
1               5           


<210>  55
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 125经KABAT分析的CDR3-VL

<400>  55

Gln His Phe Trp Val Thr Pro Trp Thr 
1               5                   


<210>  56
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 125经IMGT分析的CDR1-VL

<400>  56

Glu Asn Ile Tyr Ser Asn 
1               5       


<210>  57
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 125经IMGT分析的CDR2-VL

<400>  57

Asp Ala Thr 
1           


<210>  58
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 125经IMGT分析的CDR3-VL

<400>  58

Gln His Phe Trp Val Thr Pro Trp Thr 
1               5                   


<210>  59
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 133经KABAT分析的CDR1-VH

<400>  59

Asp Tyr Tyr Ile Gln 
1               5   


<210>  60
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 133经KABAT分析的CDR2-VH

<400>  60

Trp Ile Asp Pro Glu Ser Gly Asn Thr Lys Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  61
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 133经KABAT分析的CDR3-VH

<400>  61

Tyr Tyr Asp Tyr Asp Gly Ser Met Asp Tyr 
1               5                   10  


<210>  62
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 133经IMGT分析的CDR1-VH

<400>  62

Gly Phe Asn Ile Lys Asp Tyr Tyr 
1               5               


<210>  63
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 133经IMGT分析的CDR2-VH

<400>  63

Ile Asp Pro Glu Ser Gly Asn Thr 
1               5               


<210>  64
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 133经IMGT分析的CDR3-VH

<400>  64

Asn Ala Tyr Tyr Asp Tyr Asp Gly Ser Met Asp Tyr 
1               5                   10          


<210>  65
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 133经KABAT分析的CDR1-VL

<400>  65

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  66
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 133经KABAT分析的CDR2-VL

<400>  66

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  67
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 133经KABAT分析的CDR3-VL

<400>  67

Ser Gln Ser Thr His Val Pro Thr Trp Thr 
1               5                   10  


<210>  68
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 133经IMGT分析的CDR1-VL

<400>  68

Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  69
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 133经IMGT分析的CDR2-VL

<400>  69

Lys Val Ser 
1           


<210>  70
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 133经IMGT分析的CDR3-VL

<400>  70

Ser Gln Ser Thr His Val Pro Thr Trp Thr 
1               5                   10  


<210>  71
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 219经KABAT分析的CDR1-VH

<400>  71

Asn Tyr Trp Met Asn 
1               5   


<210>  72
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 219经KABAT分析的CDR2-VH

<400>  72

Met Ile His Pro Ser Asp Thr Glu Thr Arg Leu Asn Gln Asn Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  73
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 219经KABAT分析的CDR3-VH

<400>  73

Gly Glu Gly Leu Gly Ala Ala Arg Ser Val Ser Met Asp Tyr 
1               5                   10                  


<210>  74
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 219经IMGT分析的CDR1-VH

<400>  74

Gly Tyr Ser Phe Thr Asn Tyr Trp 
1               5               


<210>  75
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 219经IMGT分析的CDR2-VH

<400>  75

Ile His Pro Ser Asp Thr Glu Thr 
1               5               


<210>  76
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 219经IMGT分析的CDR3-VH

<400>  76

Ala Arg Gly Glu Gly Leu Gly Ala Ala Arg Ser Val Ser Met Asp Tyr 
1               5                   10                  15      


<210>  77
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 219经KABAT分析的CDR1-VL

<400>  77

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  78
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 219经KABAT分析的CDR2-VL

<400>  78

Tyr Thr Ala Ile Leu His Ser 
1               5           


<210>  79
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 219经KABAT分析的CDR3-VL

<400>  79

Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  80
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 219经IMGT分析的CDR1-VL

<400>  80

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  81
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 219经IMGT分析的CDR2-VL

<400>  81

Tyr Thr Ala 
1           


<210>  82
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 219经IMGT分析的CDR3-VL

<400>  82

Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  83
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 224经KABAT分析的CDR1-VH

<400>  83

Asp Ile Tyr Met His 
1               5   


<210>  84
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 224经KABAT分析的CDR2-VH

<400>  84

Arg Ile Asp Pro Ala Thr Gly Asn Thr Lys His Asp Pro Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  85
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 224经KABAT分析的CDR3-VH

<400>  85

Ser Pro Tyr Gly Asp Phe Gly Ala Met Asp Tyr 
1               5                   10      


<210>  86
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 224经IMGT分析的CDR1-VH

<400>  86

Gly Phe Asn Asn Lys Asp Ile Tyr 
1               5               


<210>  87
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 224经IMGT分析的CDR2-VH

<400>  87

Ile Asp Pro Ala Thr Gly Asn Thr 
1               5               


<210>  88
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 224经IMGT分析的CDR3-VH

<400>  88

Ala His Ser Pro Tyr Gly Asp Phe Gly Ala Met Asp Tyr 
1               5                   10              


<210>  89
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 224经KABAT分析的CDR1-VL

<400>  89

Thr Ala Ser Ser Ser Val Ser Ser Asn Tyr Leu His 
1               5                   10          


<210>  90
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 224经KABAT分析的CDR2-VL

<400>  90

Ser Thr Ser Asn Leu Pro Ser 
1               5           


<210>  91
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 224经KABAT分析的CDR3-VL

<400>  91

His Gln Tyr His Arg Ser Pro Trp Thr 
1               5                   


<210>  92
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 224经IMGT分析的CDR1-VL

<400>  92

Ser Ser Val Ser Ser Asn Tyr 
1               5           


<210>  93
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 224经IMGT分析的CDR2-VL

<400>  93

Ser Thr Ser 
1           


<210>  94
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 224经IMGT分析的CDR3-VL

<400>  94

His Gln Tyr His Arg Ser Pro Trp Thr 
1               5                   


<210>  95
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 226经KABAT分析的CDR1-VH

<400>  95

Asn Tyr Trp Met Asn 
1               5   


<210>  96
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 226经KABAT分析的CDR2-VH

<400>  96

Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  97
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 226经KABAT分析的CDR3-VH

<400>  97

Gly Glu Gly Leu Gly Ala Ala Arg Ser Val Ser Met Asp Tyr 
1               5                   10                  


<210>  98
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 226经IMGT分析的CDR1-VH

<400>  98

Gly Tyr Ser Phe Thr Asn Tyr Trp 
1               5               


<210>  99
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 226经IMGT分析的CDR2-VH

<400>  99

Ile His Pro Ser Asp Ser Glu Thr 
1               5               


<210>  100
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 226经IMGT分析的CDR3-VH

<400>  100

Ala Arg Gly Glu Gly Leu Gly Ala Ala Arg Ser Val Ser Met Asp Tyr 
1               5                   10                  15      


<210>  101
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 226经KABAT分析的CDR1-VL

<400>  101

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  102
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 226经KABAT分析的CDR2-VL

<400>  102

Tyr Thr Ala Leu Leu His Ser 
1               5           


<210>  103
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 226经KABAT分析的CDR3-VL

<400>  103

Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  104
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 226经IMGT分析的CDR1-VL

<400>  104

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  105
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 226经IMGT分析的CDR2-VL

<400>  105

Tyr Thr Ala 
1           


<210>  106
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 226经IMGT分析的CDR3-VL

<400>  106

Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  107
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 309经KABAT分析的CDR1-VH

<400>  107

Ser Tyr Trp Ile His 
1               5   


<210>  108
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 309经KABAT分析的CDR2-VH

<400>  108

Glu Ile Asn Pro Asn Asn Gly Gly Thr Asp Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Arg 
    


<210>  109
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 309经KABAT分析的CDR3-VH

<400>  109

Asp Ser Met Ile Thr Thr Thr Trp Phe Ala Tyr 
1               5                   10      


<210>  110
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 309经IMGT分析的CDR1-VH

<400>  110

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  111
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 309经IMGT分析的CDR2-VH

<400>  111

Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               


<210>  112
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 309经IMGT分析的CDR3-VH

<400>  112

Thr Ile Asp Ser Met Ile Thr Thr Thr Trp Phe Ala Tyr 
1               5                   10              


<210>  113
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 309经KABAT分析的CDR1-VL

<400>  113

Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala 
1               5                   10      


<210>  114
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 309经KABAT分析的CDR2-VL

<400>  114

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  115
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 309经KABAT分析的CDR3-VL

<400>  115

Gln Gln Tyr Asn Ser Tyr Pro Phe Thr 
1               5                   


<210>  116
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 309经IMGT分析的CDR1-VL

<400>  116

Gln Asn Val Gly Thr Asn 
1               5       


<210>  117
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 309经IMGT分析的CDR2-VL

<400>  117

Ser Ala Ser 
1           


<210>  118
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 309经IMGT分析的CDR3-VL

<400>  118

Gln Gln Tyr Asn Ser Tyr Pro Phe Thr 
1               5                   


<210>  119
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 352经KABAT分析的CDR1-VH

<400>  119

Ser Tyr Gly Val His 
1               5   


<210>  120
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 352经KABAT分析的CDR2-VH

<400>  120

Val Ile Trp Ser Asp Gly Gly Thr Thr Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  121
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 352经KABAT分析的CDR3-VH

<400>  121

His Asp Asp Asp Gly Tyr Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  122
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 352经IMGT分析的CDR1-VH

<400>  122

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  123
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 352经IMGT分析的CDR2-VH

<400>  123

Ile Trp Ser Asp Gly Gly Thr 
1               5           


<210>  124
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 352经IMGT分析的CDR3-VH

<400>  124

Ala Arg His Asp Asp Asp Gly Tyr Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  125
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 352经KABAT分析的CDR1-VL

<400>  125

Ser Ala Ser Ser Ser Val Gly Tyr Met Tyr 
1               5                   10  


<210>  126
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 352经KABAT分析的CDR2-VL

<400>  126

Leu Thr Ser Asn Leu Ala Ser 
1               5           


<210>  127
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 352经KABAT分析的CDR3-VL

<400>  127

Gln Gln Trp Ser Ser Asp Pro Phe Thr 
1               5                   


<210>  128
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 352经IMGT分析的CDR1-VL

<400>  128

Ser Ser Val Gly Tyr 
1               5   


<210>  129
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 352经IMGT分析的CDR2-VL

<400>  129

Leu Thr Ser 
1           


<210>  130
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 352经IMGT分析的CDR3-VL

<400>  130

Gln Gln Trp Ser Ser Asp Pro Phe Thr 
1               5                   


<210>  131
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 365经KABAT分析的CDR1-VH

<400>  131

Ser Tyr Gly Val His 
1               5   


<210>  132
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 365经KABAT分析的CDR2-VH

<400>  132

Leu Ile Trp Ser Asp Gly Ser Pro Asp Tyr Ser Ala Ala Phe Ile Ser 
1               5                   10                  15      


<210>  133
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 365经KABAT分析的CDR3-VH

<400>  133

Asn Asp Asp Gly Gly Asp Tyr Val Met Asp Tyr 
1               5                   10      


<210>  134
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 365经IMGT分析的CDR1-VH

<400>  134

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  135
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 365经IMGT分析的CDR2-VH

<400>  135

Ile Trp Ser Asp Gly Ser Pro 
1               5           


<210>  136
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 365经IMGT分析的CDR3-VH

<400>  136

Ala Arg Asn Asp Asp Gly Gly Asp Tyr Val Met Asp Tyr 
1               5                   10              


<210>  137
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 365经KABAT分析的CDR1-VL

<400>  137

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  138
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 365经KABAT分析的CDR2-VL

<400>  138

Leu Thr Ser Asn Leu Ala Ser 
1               5           


<210>  139
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 365经KABAT分析的CDR3-VL

<400>  139

Gln Gln Trp Thr Ser Asn Pro Leu Thr 
1               5                   


<210>  140
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 365经IMGT分析的CDR1-VL

<400>  140

Ser Ser Val Ser Tyr 
1               5   


<210>  141
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 365经IMGT分析的CDR2-VL

<400>  141

Leu Thr Ser 
1           


<210>  142
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 365经IMGT分析的CDR3-VL

<400>  142

Gln Gln Trp Thr Ser Asn Pro Leu Thr 
1               5                   


<210>  143
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 395经KABAT分析的CDR1-VH

<400>  143

Ser Tyr Ser Val His 
1               5   


<210>  144
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 395经KABAT分析的CDR2-VH

<400>  144

Val Ile Trp Ser Asp Gly Gly Thr Asp Tyr Ser Ala Ala Phe Ile Ser 
1               5                   10                  15      


<210>  145
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 395经KABAT分析的CDR3-VH

<400>  145

Asn Asp Asp Gly Gly Asp Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  146
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 395经IMGT分析的CDR1-VH

<400>  146

Gly Phe Ser Leu Thr Ser Tyr Ser 
1               5               


<210>  147
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 395经IMGT分析的CDR2-VH

<400>  147

Ile Trp Ser Asp Gly Gly Thr 
1               5           


<210>  148
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 395经IMGT分析的CDR3-VH

<400>  148

Ala Arg Asn Asp Asp Gly Gly Asp Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  149
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 395经KABAT分析的CDR1-VL

<400>  149

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  150
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 395经KABAT分析的CDR2-VL

<400>  150

Leu Thr Ser Asn Leu Ala Ser 
1               5           


<210>  151
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 395经KABAT分析的CDR3-VL

<400>  151

Gln Gln Trp Ser Ser Asn Pro Leu Thr 
1               5                   


<210>  152
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 395经IMGT分析的CDR1-VL

<400>  152

Ser Ser Val Ser Tyr 
1               5   


<210>  153
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 395经IMGT分析的CDR2-VL

<400>  153

Leu Thr Ser 
1           


<210>  154
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  阳性克隆Clone ID 395经IMGT分析的CDR3-VL

<400>  154

Gln Gln Trp Ser Ser Asn Pro Leu Thr 
1               5                   


