                         SEQUENCE LISTING

<110>  The University of North Carolina at Chapel Hill
       Li, Chengwen
       Askew, Charles
       Kuhlman, Brian
       Thieker, David Forrest
 
<120>  COMPOSITIONS AND METHODS FOR BINDING ANTIBODIES AND INHIBITING 
       NEUTRALIZING ANTIBODIES

<130>  5470-869WO

<150>  US 62/881,765
<151>  2019-08-01

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  556
<212>  PRT
<213>  Mycoplasma genitalium

<400>  1

Met Gln Phe Lys Lys His Lys Asn Ser Val Lys Phe Lys Arg Lys Leu 
1               5                   10                  15      


Phe Trp Thr Ile Gly Val Leu Gly Ala Gly Ala Leu Thr Thr Phe Ser 
            20                  25                  30          


Ala Val Met Ile Thr Asn Leu Val Asn Gln Ser Gly Tyr Ala Leu Val 
        35                  40                  45              


Ala Ser Gly Arg Ser Gly Asn Leu Gly Phe Lys Leu Phe Ser Thr Gln 
    50                  55                  60                  


Ser Pro Ser Ala Glu Val Lys Leu Lys Ser Leu Ser Leu Asn Asp Gly 
65                  70                  75                  80  


Ser Tyr Gln Ser Glu Ile Asp Leu Ser Gly Gly Ala Asn Phe Arg Glu 
                85                  90                  95      


Lys Phe Arg Asn Phe Ala Asn Glu Leu Ser Glu Ala Ile Thr Asn Ser 
            100                 105                 110         


Pro Lys Gly Leu Asp Arg Pro Val Pro Lys Thr Glu Ile Ser Gly Leu 
        115                 120                 125             


Ile Lys Thr Gly Asp Asn Phe Ile Thr Pro Ser Phe Lys Ala Gly Tyr 
    130                 135                 140                 


Tyr Asp His Val Ala Ser Asp Gly Ser Leu Leu Ser Tyr Tyr Gln Ser 
145                 150                 155                 160 


Thr Glu Tyr Phe Asn Asn Arg Val Leu Met Pro Ile Leu Gln Thr Thr 
                165                 170                 175     


Asn Gly Thr Leu Met Ala Asn Asn Arg Gly Tyr Asp Asp Val Phe Arg 
            180                 185                 190         


Gln Val Pro Ser Phe Ser Gly Trp Ser Asn Thr Lys Ala Thr Thr Val 
        195                 200                 205             


Ser Thr Ser Asn Asn Leu Thr Tyr Asp Lys Trp Thr Tyr Phe Ala Ala 
    210                 215                 220                 


Lys Gly Ser Pro Leu Tyr Asp Ser Tyr Pro Asn His Phe Phe Glu Asp 
225                 230                 235                 240 


Val Lys Thr Leu Ala Ile Asp Ala Lys Asp Ile Ser Ala Leu Lys Thr 
                245                 250                 255     


Thr Ile Asp Ser Glu Lys Pro Thr Tyr Leu Ile Ile Arg Gly Leu Ser 
            260                 265                 270         


Gly Asn Gly Ser Gln Leu Asn Glu Leu Gln Leu Pro Glu Ser Val Lys 
        275                 280                 285             


Lys Val Ser Leu Tyr Gly Asp Tyr Thr Gly Val Asn Val Ala Lys Gln 
    290                 295                 300                 


Ile Phe Ala Asn Val Val Glu Leu Glu Phe Tyr Ser Thr Ser Lys Ala 
305                 310                 315                 320 


Asn Ser Phe Gly Phe Asn Pro Leu Val Leu Gly Ser Lys Thr Asn Val 
                325                 330                 335     


Ile Tyr Asp Leu Phe Ala Ser Lys Pro Phe Thr His Ile Asp Leu Thr 
            340                 345                 350         


Gln Val Thr Leu Gln Asn Ser Asp Asn Ser Ala Ile Asp Ala Asn Lys 
        355                 360                 365             


Leu Lys Gln Ala Val Gly Asp Ile Tyr Asn Tyr Arg Arg Phe Glu Arg 
    370                 375                 380                 


Gln Phe Gln Gly Tyr Phe Ala Gly Gly Tyr Ile Asp Lys Tyr Leu Val 
385                 390                 395                 400 


Lys Asn Val Asn Thr Asn Lys Asp Ser Asp Asp Asp Leu Val Tyr Arg 
                405                 410                 415     


Ser Leu Lys Glu Leu Asn Leu His Leu Glu Glu Ala Tyr Arg Glu Gly 
            420                 425                 430         


Asp Asn Thr Tyr Tyr Arg Val Asn Glu Asn Tyr Tyr Pro Gly Ala Ser 
        435                 440                 445             


Ile Tyr Glu Asn Glu Arg Ala Ser Arg Asp Ser Glu Phe Gln Asn Glu 
    450                 455                 460                 


Ile Leu Lys Arg Ala Glu Gln Asn Gly Val Thr Phe Asp Glu Asn Ile 
465                 470                 475                 480 


Lys Arg Ile Thr Ala Ser Gly Lys Tyr Ser Val Gln Phe Gln Lys Leu 
                485                 490                 495     


Glu Asn Asp Thr Asp Ser Ser Leu Glu Arg Met Thr Lys Ala Val Glu 
            500                 505                 510         


Gly Leu Val Thr Val Ile Gly Glu Glu Lys Phe Glu Thr Val Asp Ile 
        515                 520                 525             


Thr Gly Val Ser Ser Asp Thr Asn Glu Val Lys Ser Leu Ala Lys Glu 
    530                 535                 540                 


Leu Lys Thr Asn Ala Leu Gly Val Lys Leu Lys Leu 
545                 550                 555     


<210>  2
<211>  538
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  2

His His His His His His Ser Ser Gly Leu Val Pro Arg Gly Ser His 
1               5                   10                  15      


Met Thr Asn Leu Val Asn Gln Ser Gly Tyr Ala Leu Val Ala Ser Gly 
            20                  25                  30          


Arg Ser Gly Asn Leu Gly Phe Lys Leu Phe Ser Thr Gln Ser Pro Ser 
        35                  40                  45              


Ala Glu Val Lys Leu Lys Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln 
    50                  55                  60                  


Ser Glu Ile Asp Leu Ser Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg 
65                  70                  75                  80  


Asn Phe Ala Asn Glu Leu Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly 
                85                  90                  95      


Leu Asp Arg Pro Val Pro Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr 
            100                 105                 110         


Gly Asp Asn Phe Ile Thr Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His 
        115                 120                 125             


Val Ala Ser Asp Gly Ser Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr 
    130                 135                 140                 


Phe Asn Asn Arg Val Leu Met Pro Ile Leu Gln Thr Thr Asn Gly Thr 
145                 150                 155                 160 


Leu Met Ala Asn Asn Arg Gly Tyr Asp Asp Val Phe Arg Gln Val Pro 
                165                 170                 175     


Ser Phe Ser Gly Trp Ser Asn Thr Lys Ala Thr Thr Val Ser Thr Ser 
            180                 185                 190         


Asn Asn Leu Thr Tyr Asp Lys Trp Thr Tyr Phe Ala Ala Lys Gly Ala 
        195                 200                 205             


Ser Pro Leu Tyr Asp Ser Tyr Pro Asn His Phe Phe Glu Asp Val Lys 
    210                 215                 220                 


Thr Leu Ala Ile Asp Ala Lys Asp Ile Ser Ala Leu Lys Thr Thr Ile 
225                 230                 235                 240 


Asp Ser Glu Lys Pro Thr Tyr Leu Ile Ile Arg Gly Leu Ser Gly Asn 
                245                 250                 255     


Gly Ser Gln Leu Asn Glu Leu Gln Leu Pro Glu Ser Val Lys Lys Val 
            260                 265                 270         


Ser Leu Tyr Gly Asp Tyr Thr Gly Val Asn Val Ala Lys Gln Ile Phe 
        275                 280                 285             


Ala Asn Val Val Glu Leu Glu Phe Tyr Ser Thr Ser Lys Ala Asn Ser 
    290                 295                 300                 


Glu Gly Phe Asn Pro Leu Val Leu Gly Ser Lys Thr Asn Val Ile Tyr 
305                 310                 315                 320 


Asp Leu Phe Ala Ser Lys Pro Phe Thr His Ile Asp Leu Thr Gln Val 
                325                 330                 335     


Thr Leu Gln Asn Ser Asp Asn Ser Ala Ile Asp Ala Asn Lys Leu Lys 
            340                 345                 350         


Gln Ala Val Gly Asp Ile Tyr Asn Tyr Arg Arg Phe Glu Arg Gln Phe 
        355                 360                 365             


Gln Gly Tyr Phe Ala Gly Gly Tyr Ile Asp Lys Tyr Leu Val Lys Asn 
    370                 375                 380                 


Val Asn Thr Asn Lys Asp Ser Asp Asp Asp Leu Val Tyr Arg Ser Leu 
385                 390                 395                 400 


Lys Glu Leu Asn Leu His Leu Glu Glu Ala Tyr Arg Glu Gly Asp Asn 
                405                 410                 415     


Thr Tyr Tyr Arg Val Asn Glu Asn Tyr Tyr Pro Gly Ala Ser Ile Tyr 
            420                 425                 430         


Glu Asn Glu Arg Ala Ser Arg Asp Ser Glu Phe Gln Asn Glu Ile Leu 
        435                 440                 445             


Lys Arg Ala Glu Gln Asn Gly Val Thr Phe Asp Glu Asn Ile Lys Arg 
    450                 455                 460                 


Ile Thr Ala Ser Gly Lys Tyr Ser Val Gln Phe Gln Lys Leu Glu Asn 
465                 470                 475                 480 


Asp Thr Asp Ser Ser Leu Glu Arg Met Thr Lys Ala Val Glu Gly Leu 
                485                 490                 495     


Val Thr Val Ile Gly Glu Glu Lys Phe Glu Thr Val Asp Ile Thr Gly 
            500                 505                 510         


Val Ser Ser Asp Thr Asn Glu Val Lys Ser Leu Ala Lys Glu Leu Lys 
        515                 520                 525             


Thr Asn Ala Leu Gly Val Lys Leu Lys Leu 
    530                 535             


<210>  3
<211>  406
<212>  PRT
<213>  Mycoplasma genitalium

<400>  3

Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln Ser Glu Ile Asp Leu Ser 
1               5                   10                  15      


Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg Asn Phe Ala Asn Glu Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly Leu Asp Arg Pro Val Pro 
        35                  40                  45              


Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr Gly Asp Asn Phe Ile Thr 
    50                  55                  60                  


Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His Val Ala Ser Asp Gly Ser 
65                  70                  75                  80  


Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Leu 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Met Ala Asn Asn Arg 
            100                 105                 110         


Gly Tyr Asp Asp Val Phe Arg Gln Val Pro Ser Phe Ser Gly Trp Ser 
        115                 120                 125             


Asn Thr Lys Ala Thr Thr Val Ser Thr Ser Asn Asn Leu Thr Tyr Asp 
    130                 135                 140                 


Lys Trp Thr Tyr Phe Ala Ala Lys Gly Ser Pro Leu Tyr Asp Ser Tyr 
145                 150                 155                 160 


Pro Asn His Phe Phe Glu Asp Val Lys Thr Leu Ala Ile Asp Ala Lys 
                165                 170                 175     


Asp Ile Ser Ala Leu Lys Thr Thr Ile Asp Ser Glu Lys Pro Thr Tyr 
            180                 185                 190         


Leu Ile Ile Arg Gly Leu Ser Gly Asn Gly Ser Gln Leu Asn Glu Leu 
        195                 200                 205             


Gln Leu Pro Glu Ser Val Lys Lys Val Ser Leu Tyr Gly Asp Tyr Thr 
    210                 215                 220                 


Gly Val Asn Val Ala Lys Gln Ile Phe Ala Asn Val Val Glu Leu Glu 
225                 230                 235                 240 


Phe Tyr Ser Thr Ser Lys Ala Asn Ser Phe Gly Phe Asn Pro Leu Val 
                245                 250                 255     


Leu Gly Ser Lys Thr Asn Val Ile Asn Asp Leu Phe Ala Ser Lys Pro 
            260                 265                 270         


Phe Thr His Ile Asp Leu Thr Gln Val Thr Leu Gln Asn Ser Asp Asn 
        275                 280                 285             


Ser Ala Ile Asp Ala Asn Lys Leu Lys Gln Ala Val Gly Asp Ile Tyr 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Glu Arg Gln Phe Gln Gly Tyr Phe Ala Gly Gly 
305                 310                 315                 320 


Tyr Ile Asp Lys Tyr Leu Val Lys Asn Val Asn Thr Asn Lys Asp Ser 
                325                 330                 335     


Asp Asp Asp Leu Val Tyr Arg Ser Leu Lys Glu Leu Asn Leu His Leu 
            340                 345                 350         


Glu Glu Ala Tyr Arg Glu Gly Asp Asn Thr Tyr Tyr Arg Val Asn Glu 
        355                 360                 365             


Asn Tyr Tyr Pro Gly Ala Ser Ile Tyr Glu Asn Glu Arg Ala Ser Arg 
    370                 375                 380                 


Asp Ser Glu Phe Gln Asn Glu Ile Leu Lys Arg Ala Glu Gln Asn Gly 
385                 390                 395                 400 


Val Thr Phe Asp Glu Asn 
                405     


<210>  4
<211>  406
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  4

Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln Ser Glu Ile Asp Leu Ser 
1               5                   10                  15      


Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg Asn Phe Ala Asn Glu Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly Leu Asp Arg Pro Val Pro 
        35                  40                  45              


Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr Gly Asp Asn Phe Ile Thr 
    50                  55                  60                  


Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His Val Ala Ser Asp Gly Ser 
65                  70                  75                  80  


Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Leu 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Met Ala Asn Asn Arg 
            100                 105                 110         


Gly Tyr Asp Asp Val Phe Arg Gln Val Pro Ser Phe Ser Gly Trp Ser 
        115                 120                 125             


Asn Thr Lys Ala Thr Thr Val Ser Thr Ser Asn Asn Leu Thr Tyr Asp 
    130                 135                 140                 


Lys Trp Thr Tyr Phe Ala Ala Lys Gly Ser Pro Leu Tyr Asp Ser Tyr 
145                 150                 155                 160 


Pro Asn His Thr Phe Glu Asp Val Lys Thr Leu Ala Ile Asp Ala Lys 
                165                 170                 175     


Asp Ile Ser Ala Leu Lys Thr Thr Ile Asp Ser Glu Lys Pro Thr Tyr 
            180                 185                 190         


Leu Ile Ile Arg Gly Leu Ser Gly Asn Gly Ser Gln Leu Asn Glu Leu 
        195                 200                 205             


Gln Leu Pro Glu Ser Val Lys Lys Val Ser Leu Tyr Gly Asp Tyr Thr 
    210                 215                 220                 


Gly Val Asn Val Ala Lys Gln Ile Phe Ala Asn Val Val Glu Leu Glu 
225                 230                 235                 240 


Phe Tyr Ser Thr Ser Lys Ala Asn Ser Phe Gly Phe Asn Pro Leu Val 
                245                 250                 255     


Leu Gly Ser Lys Thr Asn Val Ile Asn Asp Leu Phe Ala Ser Lys Pro 
            260                 265                 270         


Phe Thr His Ile Asp Leu Thr Gln Val Thr Leu Gln Asn Ser Asp Asn 
        275                 280                 285             


Ser Ala Ile Asp Ala Asn Lys Leu Lys Gln Ala Val Gly Asp Ile Tyr 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Glu Arg Gln Phe Gln Gly Tyr Phe Ala Gly Gly 
305                 310                 315                 320 


Tyr Ile Asp Lys Tyr Leu Val Lys Asn Val Asn Thr Asn Lys Asp Ser 
                325                 330                 335     


Asp Asp Asp Leu Val Tyr Arg Ser Leu Lys Glu Leu Asn Leu His Leu 
            340                 345                 350         


Glu Glu Ala Tyr Arg Glu Gly Asp Asn Thr Tyr Tyr Arg Val Asn Glu 
        355                 360                 365             


Asn Tyr Tyr Pro Gly Ala Ser Ile Tyr Glu Asn Glu Arg Ala Ser Arg 
    370                 375                 380                 


Asp Ser Glu Phe Gln Asn Glu Ile Leu Lys Arg Ala Glu Gln Asn Gly 
385                 390                 395                 400 


Val Thr Phe Asp Glu Asn 
                405     


<210>  5
<211>  406
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  5

Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln Ser Glu Ile Asp Leu Ser 
1               5                   10                  15      


Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg Asn Phe Ala Asn Glu Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly Leu Asp Arg Pro Val Pro 
        35                  40                  45              


Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr Gly Asp Asn Phe Ile Thr 
    50                  55                  60                  


Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His Val Ala Ser Asp Gly Ser 
65                  70                  75                  80  


Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Leu 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Met Ala Asn Asn Arg 
            100                 105                 110         


Gly Tyr Asp Asp Val Phe Arg Gln Val Pro Ser Phe Ser Gly Trp Ser 
        115                 120                 125             


Asn Thr Lys Ala Thr Thr Val Ser Thr Ser Asn Asn Leu Thr Tyr Asp 
    130                 135                 140                 


Lys Trp Thr Tyr Phe Ala Ala Lys Gly Ser Pro Leu Tyr Asp Gln Tyr 
145                 150                 155                 160 


Pro Asn His Phe Phe Glu Asp Val Lys Thr Leu Ala Ile Asp Ala Lys 
                165                 170                 175     


Asp Ile Ser Ala Leu Lys Thr Thr Ile Asp Ser Glu Lys Pro Thr Tyr 
            180                 185                 190         


Leu Ile Ile Arg Gly Leu Ser Gly Asn Gly Ser Gln Leu Asn Glu Leu 
        195                 200                 205             


Gln Leu Pro Glu Ser Val Lys Lys Val Ser Leu Tyr Gly Asp Tyr Thr 
    210                 215                 220                 


Gly Val Asn Val Ala Lys Gln Ile Phe Ala Asn Val Val Glu Leu Glu 
225                 230                 235                 240 


Phe Tyr Ser Thr Ser Lys Ala Asn Ser Phe Gly Phe Asn Pro Leu Val 
                245                 250                 255     


Leu Gly Ser Lys Thr Asn Val Ile Asn Asp Leu Phe Ala Ser Lys Pro 
            260                 265                 270         


Phe Thr His Ile Asp Leu Thr Gln Val Thr Leu Gln Asn Ser Asp Asn 
        275                 280                 285             


Ser Ala Ile Asp Ala Asn Lys Leu Lys Gln Ala Val Gly Asp Ile Tyr 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Glu Arg Gln Phe Gln Gly Tyr Phe Ala Gly Gly 
305                 310                 315                 320 


Tyr Ile Asp Lys Tyr Leu Val Lys Asn Val Asn Thr Asn Lys Asp Ser 
                325                 330                 335     


Asp Asp Asp Leu Val Tyr Arg Ser Leu Lys Glu Leu Asn Leu His Leu 
            340                 345                 350         


Glu Glu Ala Tyr Arg Glu Gly Asp Asn Thr Tyr Tyr Arg Val Asn Glu 
        355                 360                 365             


Asn Tyr Tyr Pro Gly Ala Ser Ile Tyr Glu Asn Glu Arg Ala Ser Arg 
    370                 375                 380                 


Asp Ser Glu Phe Gln Asn Glu Ile Leu Lys Arg Ala Glu Gln Asn Gly 
385                 390                 395                 400 


Val Thr Phe Asp Glu Asn 
                405     


<210>  6
<211>  406
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  6

Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln Ser Glu Ile Asp Leu Ser 
1               5                   10                  15      


Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg Asn Phe Ala Asn Glu Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly Leu Asp Arg Pro Val Pro 
        35                  40                  45              


Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr Gly Asp Asn Phe Ile Thr 
    50                  55                  60                  


Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His Val Ala Ser Asp Gly Ser 
65                  70                  75                  80  


Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Leu 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Met Ala Asn Asn Arg 
            100                 105                 110         


Gly Tyr Asp Asp Val Phe Arg Gln Val Pro Ser Phe Ser Gly Trp Ser 
        115                 120                 125             


Asn Thr Lys Ala Thr Thr Val Ser Thr Ser Asn Asn Leu Thr Tyr Asp 
    130                 135                 140                 


Lys Trp Thr Tyr Phe Ala Ala Lys Gly Ser Pro Leu Tyr Asp Ser Tyr 
145                 150                 155                 160 


Pro Asn His Phe Phe Glu Asp Val Lys Thr Leu Ala Ile Asp Ala Lys 
                165                 170                 175     


Asp Ile Ser Ala Leu Lys Thr Thr Ile Asp Ser Glu Lys Pro Thr Tyr 
            180                 185                 190         


Leu Ile Ile Arg Gly Leu Ser Gly Asn Gly Ser Gln Leu Asn Glu Leu 
        195                 200                 205             


Asp Leu Pro Glu Ser Val Lys Lys Val Ser Leu Tyr Gly Asp Tyr Thr 
    210                 215                 220                 


Gly Val Asn Val Ala Lys Gln Ile Phe Ala Asn Val Val Glu Leu Glu 
225                 230                 235                 240 


Phe Tyr Ser Thr Ser Lys Ala Asn Ser Phe Gly Phe Asn Pro Leu Val 
                245                 250                 255     


Leu Gly Ser Lys Thr Asn Val Ile Asn Asp Leu Phe Ala Ser Lys Pro 
            260                 265                 270         


Phe Thr His Ile Asp Leu Thr Gln Val Thr Leu Gln Asn Ser Asp Asn 
        275                 280                 285             


Ser Ala Ile Asp Ala Asn Lys Leu Lys Gln Ala Val Gly Asp Ile Tyr 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Glu Arg Gln Phe Gln Gly Tyr Phe Ala Gly Gly 
305                 310                 315                 320 


Tyr Ile Asp Lys Tyr Leu Val Lys Asn Val Asn Thr Asn Lys Asp Ser 
                325                 330                 335     


Asp Asp Asp Leu Val Tyr Arg Ser Leu Lys Glu Leu Asn Leu His Leu 
            340                 345                 350         


Glu Glu Ala Tyr Arg Glu Gly Asp Asn Thr Tyr Tyr Arg Val Asn Glu 
        355                 360                 365             


Asn Tyr Tyr Pro Gly Ala Ser Ile Tyr Glu Asn Glu Arg Ala Ser Arg 
    370                 375                 380                 


Asp Ser Glu Phe Gln Asn Glu Ile Leu Lys Arg Ala Glu Gln Asn Gly 
385                 390                 395                 400 


Val Thr Phe Asp Glu Asn 
                405     


<210>  7
<211>  406
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  7

Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln Ser Glu Ile Asp Leu Ser 
1               5                   10                  15      


Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg Asn Phe Ala Asn Glu Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly Leu Asp Arg Pro Val Pro 
        35                  40                  45              


Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr Gly Asp Asn Phe Ile Thr 
    50                  55                  60                  


Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His Val Ala Glu Asp Gly Ser 
65                  70                  75                  80  


Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Leu 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Met Ala Asn Asn Arg 
            100                 105                 110         


Gly Tyr Asp Asp Val Phe Arg Gln Val Pro Arg Phe Pro Gly Trp Ser 
        115                 120                 125             


Asn Thr Lys Ala Thr Thr Val Ser Thr Ser Asn Asn Leu Thr Tyr Asp 
    130                 135                 140                 


Lys Trp Thr Tyr Phe Ala Ala Lys Gly Ser Pro Leu Tyr Asp Ser Tyr 
145                 150                 155                 160 


Pro Asn His Phe Phe Glu Asp Val Lys Thr Leu Ala Ile Asp Ala Lys 
                165                 170                 175     


Asp Ile Ser Ala Leu Lys Thr Thr Ile Asp Ser Glu Lys Pro Thr Tyr 
            180                 185                 190         


Leu Ile Ile Arg Gly Leu Ser Gly Asn Gly Ser Gln Leu Asn Glu Leu 
        195                 200                 205             


Gln Leu Pro Glu Ser Val Lys Lys Val Ser Leu Tyr Gly Asp Tyr Thr 
    210                 215                 220                 


Gly Val Asn Val Ala Lys Gln Ile Phe Ala Asn Val Val Glu Leu Glu 
225                 230                 235                 240 


Phe Tyr Ser Thr Ser Lys Ala Asn Ser Phe Gly Phe Asn Pro Leu Val 
                245                 250                 255     


Leu Gly Ser Lys Thr Asn Val Ile Asn Asp Leu Phe Ala Ser Lys Pro 
            260                 265                 270         


Phe Thr His Ile Asp Leu Thr Gln Val Thr Leu Gln Asn Ser Asp Asn 
        275                 280                 285             


Ser Ala Ile Asp Ala Asn Lys Leu Lys Gln Ala Val Gly Asp Ile Tyr 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Glu Arg Gln Phe Gln Gly Tyr Phe Ala Gly Gly 
305                 310                 315                 320 


Tyr Ile Asp Lys Tyr Leu Val Lys Asn Val Asn Thr Asn Lys Asp Ser 
                325                 330                 335     


Asp Asp Asp Leu Val Tyr Arg Ser Leu Lys Glu Leu Asn Leu His Leu 
            340                 345                 350         


Glu Glu Ala Tyr Arg Glu Gly Asp Asn Thr Tyr Tyr Arg Val Asn Glu 
        355                 360                 365             


Asn Tyr Tyr Pro Gly Ala Ser Ile Tyr Glu Asn Glu Arg Ala Ser Arg 
    370                 375                 380                 


Asp Ser Glu Phe Gln Asn Glu Ile Leu Lys Arg Ala Glu Gln Asn Gly 
385                 390                 395                 400 


Val Thr Phe Asp Glu Asn 
                405     


<210>  8
<211>  406
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  8

Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln Ser Glu Ile Asp Leu Ser 
1               5                   10                  15      


Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg Asn Phe Ala Asn Glu Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly Leu Asp Arg Pro Val Pro 
        35                  40                  45              


Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr Gly Asp Asn Phe Ile Thr 
    50                  55                  60                  


Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His Val Ala Ser Asp Gly Ser 
65                  70                  75                  80  


Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Leu 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Met Ala Asn Asn Arg 
            100                 105                 110         


Gly Tyr Asp Asp Val Phe Arg Gln Val Pro Ser Phe Ser Gly Trp Ser 
        115                 120                 125             


Asn Thr Lys Ala Thr Thr Val Ser Thr Ser Asn Asn Leu Thr Tyr Asp 
    130                 135                 140                 


Lys Trp Thr Tyr Phe Ala Ala Lys Gly Ser Pro Leu Tyr Asp Ser Tyr 
145                 150                 155                 160 


Pro Asn His Phe Phe Glu Asp Val Lys Thr Leu Ala Ile Asp Ala Lys 
                165                 170                 175     


Asp Ile Ser Ala Leu Lys Thr Thr Ile Asp Ser Glu Lys Pro Thr Tyr 
            180                 185                 190         


Leu Ile Ile Arg Gly Leu Ser Gly Asn Gly Ser Gln Leu Asn Glu Leu 
        195                 200                 205             


Gln Leu Pro Glu Ser Val Lys Lys Val Ser Leu Tyr Gly Asp Tyr Thr 
    210                 215                 220                 


Gly Val Asn Val Ala Lys Gln Ile Phe Ala Asn Val Val Glu Leu Glu 
225                 230                 235                 240 


Phe Tyr Ser Thr Ser Lys Ala Asn Ser Phe Gly Phe Asn Pro Leu Val 
                245                 250                 255     


Leu Gly Ser Lys Thr Asn Val Ile Asn Asp Leu Phe Ala Ser Lys Pro 
            260                 265                 270         


Phe Thr His Ile Asp Leu Thr Gln Val Thr Leu Gln Asn Ser Asp Asn 
        275                 280                 285             


Ser Ala Ile Asp Ala Asn Lys Leu Lys Gln Ala Val Gly Asp Ile Tyr 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Glu Arg Gln Phe Gln Gly Tyr Phe Ala Gly Gly 
305                 310                 315                 320 


Tyr Ile Asp Lys Tyr Leu Ile Lys Ile Val Asn Thr Asn Pro Asp Val 
                325                 330                 335     


Asp Asp Asp Ile Val Tyr Arg Ser Leu Lys Glu Leu Asn Leu His Leu 
            340                 345                 350         


Glu Glu Ala Tyr Arg Glu Gly Asp Asn Ile Tyr Tyr Arg Val Asn Glu 
        355                 360                 365             


Asn Tyr Tyr Pro Gly Ala Ser Ile Tyr Glu Asn Glu Arg Ala Ser Arg 
    370                 375                 380                 


Asp Ser Glu Phe Gln Asn Glu Ile Leu Lys Arg Ala Glu Gln Asn Gly 
385                 390                 395                 400 


Val Thr Phe Asp Glu Asn 
                405     


<210>  9
<211>  406
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  9

Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln Ser Glu Ile Asp Leu Ser 
1               5                   10                  15      


Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg Asn Phe Ala Asn Glu Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly Leu Asp Arg Pro Val Pro 
        35                  40                  45              


Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr Gly Asp Asn Phe Ile Thr 
    50                  55                  60                  


Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His Val Ala Ser Asp Gly Ser 
65                  70                  75                  80  


Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Leu 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Met Ala Asn Asn Arg 
            100                 105                 110         


Gly Tyr Asp Asp Val Phe Arg Gln Val Pro Ser Phe Ser Gly Trp Ser 
        115                 120                 125             


Asn Thr Lys Ala Thr Thr Val Ser Thr Ser Asn Asn Leu Thr Tyr Asp 
    130                 135                 140                 


Lys Trp Thr Tyr Phe Ala Ala Lys Gly Ser Pro Leu Tyr Asp Ser Tyr 
145                 150                 155                 160 


Pro Asn His Phe Phe Glu Asp Val Lys Thr Leu Ala Ile Asp Ala Lys 
                165                 170                 175     


Asp Ile Ser Ala Leu Lys Thr Thr Ile Asp Ser Glu Lys Pro Thr Tyr 
            180                 185                 190         


Leu Ile Ile Arg Gly Leu Ser Gly Asn Gly Ser Gln Leu Asn Glu Leu 
        195                 200                 205             


Gln Leu Pro Glu Ser Val Lys Lys Val Ser Leu Tyr Gly Asp Tyr Thr 
    210                 215                 220                 


Gly Val Asn Val Ala Lys Gln Ile Phe Ala Asn Val Val Glu Leu Glu 
225                 230                 235                 240 


Phe Tyr Ser Thr Ser Lys Ala Asn Ser Phe Gly Phe Asn Pro Leu Val 
                245                 250                 255     


Leu Gly Ser Lys Thr Asn Val Ile Asn Asp Leu Phe Ala Ser Lys Pro 
            260                 265                 270         


Phe Thr His Ile Asp Leu Thr Gln Val Thr Leu Gln Asn Ser Asp Asn 
        275                 280                 285             


Ser Ala Ile Asp Ala Asn Lys Leu Lys Gln Ala Ile Gly Asp Ile Tyr 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Glu Arg Gln Phe Gln Gly Tyr Phe Ala Gly Gly 
305                 310                 315                 320 


Tyr Ile Asp Lys Tyr Leu Ile Lys Asn Val Asn Thr Asn Lys Asp Ser 
                325                 330                 335     


Asp Asp Asp Leu Val Tyr Arg Ser Leu Lys Glu Leu Asn Leu His Leu 
            340                 345                 350         


Glu Glu Ala Tyr Arg Glu Gly Asp Asn Thr Tyr Tyr Arg Val Asn Glu 
        355                 360                 365             


Asn Tyr Tyr Pro Gly Ala Ser Ile Tyr Glu Asn Glu Arg Ala Ser Arg 
    370                 375                 380                 


Asp Ser Glu Phe Gln Asn Glu Ile Leu Lys Arg Ala Glu Gln Asn Gly 
385                 390                 395                 400 


Val Thr Phe Asp Glu Asn 
                405     


<210>  10
<211>  406
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  10

Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln Ser Glu Ile Asp Leu Ser 
1               5                   10                  15      


Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg Asn Phe Ala Asn Glu Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly Leu Asp Arg Pro Val Pro 
        35                  40                  45              


Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr Gly Asp Asn Phe Ile Thr 
    50                  55                  60                  


Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His Val Ala Ser Asp Gly Ser 
65                  70                  75                  80  


Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Leu 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Met Ala Asn Asn Arg 
            100                 105                 110         


Gly Tyr Asp Asp Val Phe Arg Gln Val Pro Ser Phe Ser Gly Trp Ser 
        115                 120                 125             


Asn Thr Lys Ala Thr Thr Val Ser Thr Ser Asn Asn Leu Thr Tyr Asp 
    130                 135                 140                 


Lys Trp Thr Tyr Phe Ala Ala Lys Gly Ser Pro Leu Tyr Asp Ser Tyr 
145                 150                 155                 160 


Pro Asn His Phe Phe Glu Asp Val Lys Thr Leu Ala Ile Asp Ala Lys 
                165                 170                 175     


Asp Ile Ser Ala Leu Lys Thr Thr Ile Asp Ser Glu Lys Pro Thr Tyr 
            180                 185                 190         


Leu Ile Ile Arg Gly Leu Ser Gly Asn Gly Ser Gln Leu Asn Glu Leu 
        195                 200                 205             


Gln Leu Pro Glu Ser Val Lys Lys Val Ser Leu Tyr Gly Asp Tyr Thr 
    210                 215                 220                 


Gly Val Asn Val Ala Lys Gln Ile Phe Ala Asn Val Val Glu Leu Glu 
225                 230                 235                 240 


Phe Tyr Ser Thr Ser Lys Ala Asn Ser Phe Gly Phe Asn Pro Leu Val 
                245                 250                 255     


Leu Gly Ser Lys Thr Asn Val Ile Asn Asp Leu Phe Ala Ser Lys Pro 
            260                 265                 270         


Phe Thr His Ile Asp Leu Thr Gln Val Thr Leu Gln Asn Ser Asp Asn 
        275                 280                 285             


Ser Ala Ile Asp Ala Asn Lys Leu Lys Gln Ala Val Gly Asp Ile Tyr 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Glu Arg Gln Phe Gln Gly Tyr Phe Ala Gly Gly 
305                 310                 315                 320 


Tyr Ile Asp Lys Tyr Leu Val Lys Leu Val Asn Thr Asn Pro Asp Val 
                325                 330                 335     


Asp Asp Asp Ile Val Tyr Arg Ser Leu Lys Glu Leu Asn Leu His Leu 
            340                 345                 350         


Glu Glu Ala Tyr Arg Glu Gly Asp Asn Thr Tyr Tyr Arg Val Asn Glu 
        355                 360                 365             


Asn Tyr Tyr Pro Gly Ala Ser Ile Tyr Glu Asn Glu Arg Ala Ser Arg 
    370                 375                 380                 


Asp Ser Glu Phe Gln Asn Glu Ile Leu Lys Arg Ala Glu Gln Asn Gly 
385                 390                 395                 400 


Val Thr Phe Asp Glu Asn 
                405     


<210>  11
<211>  406
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  11

Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln Ser Glu Ile Asp Leu Ser 
1               5                   10                  15      


Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg Asn Phe Ala Asn Glu Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly Leu Asp Arg Pro Val Pro 
        35                  40                  45              


Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr Gly Asp Asn Phe Ile Thr 
    50                  55                  60                  


Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His Val Ala Ser Asp Gly Ser 
65                  70                  75                  80  


Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Leu 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Met Ala Asn Asn Arg 
            100                 105                 110         


Gly Tyr Asp Asp Val Phe Arg Gln Val Pro Ser Phe Ser Gly Trp Ser 
        115                 120                 125             


Asn Thr Lys Ala Thr Thr Val Ser Thr Ser Asn Asn Leu Thr Tyr Asp 
    130                 135                 140                 


Lys Trp Thr Tyr Phe Ala Ala Lys Gly Ser Pro Leu Tyr Asp Ser Tyr 
145                 150                 155                 160 


Pro Asn His Phe Phe Glu Asp Val Lys Thr Leu Ala Ile Asp Ala Lys 
                165                 170                 175     


Asp Ile Ser Ala Leu Lys Thr Thr Ile Asp Ser Glu Lys Pro Thr Tyr 
            180                 185                 190         


Leu Ile Ile Arg Gly Leu Ser Gly Asn Gly Ser Gln Leu Asn Glu Leu 
        195                 200                 205             


Gln Leu Pro Glu Ser Val Lys Lys Val Ser Leu Tyr Gly Asp Tyr Thr 
    210                 215                 220                 


Gly Val Asn Val Ala Lys Gln Ile Phe Ala Asn Val Val Glu Leu Glu 
225                 230                 235                 240 


Phe Tyr Ser Thr Ser Lys Ala Asn Ser Phe Gly Phe Asn Pro Leu Val 
                245                 250                 255     


Leu Gly Ser Lys Thr Asn Val Ile Asn Asp Leu Phe Val Ser Lys Pro 
            260                 265                 270         


Phe Thr His Ile Asp Leu Thr Gln Val Thr Leu Gln Asn Ser Asp Asn 
        275                 280                 285             


Ser Ala Ile Asp Ala Asn Lys Leu Lys Gln Ala Val Gly Asp Ile Tyr 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Glu Arg Gln Phe Gln Gly Tyr Phe Ala Gly Gly 
305                 310                 315                 320 


Tyr Ile Asp Lys Tyr Leu Val Lys Asn Val Asn Thr Asn Lys Asp Ser 
                325                 330                 335     


Asp Asp Asp Leu Val Tyr Arg Ser Leu Lys Glu Leu Asn Leu His Leu 
            340                 345                 350         


Glu Glu Ala Tyr Arg Glu Gly Asp Asn Thr Tyr Tyr Arg Val Asn Glu 
        355                 360                 365             


Asn Tyr Tyr Pro Gly Ala Ser Ile Tyr Glu Asn Glu Arg Ala Ser Arg 
    370                 375                 380                 


Asp Ser Glu Phe Gln Asn Glu Ile Leu Lys Arg Ala Glu Gln Asn Gly 
385                 390                 395                 400 


Val Thr Phe Asp Glu Asn 
                405     


<210>  12
<211>  406
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  12

Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln Ser Glu Ile Asp Leu Ser 
1               5                   10                  15      


Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg Asn Phe Ala Asn Glu Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly Leu Asp Arg Pro Val Pro 
        35                  40                  45              


Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr Gly Asp Asn Phe Ile Thr 
    50                  55                  60                  


Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His Val Ala Glu Asp Gly Ser 
65                  70                  75                  80  


Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Leu 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Met Ala Asn Asn Arg 
            100                 105                 110         


Gly Tyr Asp Asp Val Phe Arg Gln Val Pro Arg Phe Pro Gly Trp Ser 
        115                 120                 125             


Asn Thr Lys Ala Thr Thr Val Ser Thr Ser Asn Asn Leu Thr Tyr Asp 
    130                 135                 140                 


Lys Trp Thr Tyr Phe Ala Ala Lys Gly Ser Pro Leu Tyr Asp Gln Tyr 
145                 150                 155                 160 


Pro Asn His Thr Phe Glu Asp Val Lys Thr Leu Ala Ile Asp Ala Lys 
                165                 170                 175     


Asp Ile Ser Ala Leu Lys Thr Thr Ile Asp Ser Glu Lys Pro Thr Tyr 
            180                 185                 190         


Leu Ile Ile Arg Gly Leu Ser Gly Asn Gly Ser Gln Leu Asn Glu Leu 
        195                 200                 205             


Asp Leu Pro Glu Ser Val Lys Lys Val Ser Leu Tyr Gly Asp Tyr Thr 
    210                 215                 220                 


Gly Val Asn Val Ala Lys Gln Ile Phe Ala Asn Val Val Glu Leu Glu 
225                 230                 235                 240 


Phe Tyr Ser Thr Ser Lys Ala Asn Ser Phe Gly Phe Asn Pro Leu Val 
                245                 250                 255     


Leu Gly Ser Lys Thr Asn Val Ile Asn Asp Leu Phe Val Ser Lys Pro 
            260                 265                 270         


Phe Thr His Ile Asp Leu Thr Gln Val Thr Leu Gln Asn Ser Asp Asn 
        275                 280                 285             


Ser Ala Ile Asp Ala Asn Lys Leu Lys Gln Ala Ile Gly Asp Ile Tyr 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Glu Arg Gln Phe Gln Gly Tyr Phe Ala Gly Gly 
305                 310                 315                 320 


Tyr Ile Asp Lys Tyr Leu Ile Lys Ile Val Asn Thr Asn Pro Asp Val 
                325                 330                 335     


Asp Asp Asp Ile Val Tyr Arg Ser Leu Lys Glu Leu Asn Leu His Leu 
            340                 345                 350         


Glu Glu Ala Tyr Arg Glu Gly Asp Asn Ile Tyr Tyr Arg Val Asn Glu 
        355                 360                 365             


Asn Tyr Tyr Pro Gly Ala Ser Ile Tyr Glu Asn Glu Arg Ala Ser Arg 
    370                 375                 380                 


Asp Ser Glu Phe Gln Asn Glu Ile Leu Lys Arg Ala Glu Gln Asn Gly 
385                 390                 395                 400 


Val Thr Phe Asp Glu Asn 
                405     


<210>  13
<211>  406
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  13

Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln Ser Glu Ile Asp Leu Ser 
1               5                   10                  15      


Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg Asn Phe Ala Asn Glu Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly Leu Asp Arg Pro Val Pro 
        35                  40                  45              


Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr Gly Asp Asn Phe Ile Thr 
    50                  55                  60                  


Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His Val Ala Ser Asp Gly Ser 
65                  70                  75                  80  


Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Leu 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Met Ala Asn Asn Arg 
            100                 105                 110         


Gly Tyr Asp Asp Val Phe Arg Gln Val Pro Ser Phe Ser Gly Trp Ser 
        115                 120                 125             


Asn Thr Lys Ala Thr Thr Val Ser Thr Ser Asn Asn Leu Thr Tyr Asp 
    130                 135                 140                 


Lys Trp Thr Tyr Phe Ala Ala Lys Gly Ser Pro Leu Tyr Asp Ser Tyr 
145                 150                 155                 160 


Pro Asn His Phe Phe Glu Asp Val Lys Thr Leu Ala Ile Asp Ala Lys 
                165                 170                 175     


Asp Ile Ser Ala Leu Lys Thr Thr Ile Asp Ser Glu Lys Pro Thr Tyr 
            180                 185                 190         


Leu Ile Ile Arg Gly Leu Ser Gly Asp Gly Ser Gln Leu Asn Glu Leu 
        195                 200                 205             


Gln Leu Pro Glu Ser Val Lys Lys Val Ser Leu Tyr Gly Asp Tyr Thr 
    210                 215                 220                 


Gly Val Asn Val Ala Lys Gln Ile Phe Ala Asn Val Val Glu Leu Glu 
225                 230                 235                 240 


Phe Tyr Ser Thr Ser Lys Ala Asn Ser Phe Gly Phe Asn Pro Leu Val 
                245                 250                 255     


Leu Gly Ser Lys Thr Asn Val Ile Asn Asp Leu Phe Ala Ser Lys Pro 
            260                 265                 270         


Phe Thr His Ile Asp Leu Thr Gln Val Thr Leu Gln Asn Ser Asp Asn 
        275                 280                 285             


Ser Ala Ile Asp Ala Asn Lys Leu Lys Gln Ala Val Gly Asp Ile Tyr 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Glu Arg Gln Phe Gln Gly Tyr Phe Ala Gly Gly 
305                 310                 315                 320 


Tyr Ile Asp Lys Tyr Leu Val Lys Asn Val Asn Thr Asn Lys Asp Ser 
                325                 330                 335     


Asp Asp Asp Leu Val Tyr Arg Ser Leu Lys Glu Leu Asn Leu His Leu 
            340                 345                 350         


Glu Glu Ala Tyr Arg Glu Gly Asp Asn Thr Tyr Tyr Arg Val Asn Glu 
        355                 360                 365             


Asn Tyr Tyr Pro Gly Ala Ser Ile Tyr Glu Asn Glu Arg Ala Ser Arg 
    370                 375                 380                 


Asp Ser Glu Phe Gln Asn Glu Ile Leu Lys Arg Ala Glu Gln Asn Gly 
385                 390                 395                 400 


Val Thr Phe Asp Glu Asn 
                405     


<210>  14
<211>  406
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  14

Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln Ser Glu Ile Asp Leu Ser 
1               5                   10                  15      


Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg Asn Phe Ala Asn Glu Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly Leu Asp Arg Pro Val Pro 
        35                  40                  45              


Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr Gly Asp Asn Phe Ile Thr 
    50                  55                  60                  


Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His Val Ala Glu Asp Gly Ser 
65                  70                  75                  80  


Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Leu 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Met Ala Asn Asn Arg 
            100                 105                 110         


Gly Tyr Asp Asp Val Phe Arg Gln Val Pro Arg Phe Pro Gly Trp Ser 
        115                 120                 125             


Asn Thr Lys Ala Thr Thr Val Ser Thr Ser Asn Asn Leu Thr Tyr Asp 
    130                 135                 140                 


Lys Trp Thr Tyr Phe Ala Ala Lys Gly Ser Pro Leu Tyr Asp Gln Tyr 
145                 150                 155                 160 


Pro Asn His Thr Phe Glu Asp Val Lys Thr Leu Ala Ile Asp Ala Lys 
                165                 170                 175     


Asp Ile Ser Ala Leu Lys Thr Thr Ile Asp Ser Glu Lys Pro Thr Tyr 
            180                 185                 190         


Leu Ile Ile Arg Gly Leu Ser Gly Asn Gly Ser Gln Leu Asn Glu Leu 
        195                 200                 205             


Gln Leu Pro Glu Ser Val Lys Lys Val Ser Leu Tyr Gly Asp Tyr Thr 
    210                 215                 220                 


Gly Val Asn Val Ala Lys Gln Ile Phe Ala Asn Val Val Glu Leu Glu 
225                 230                 235                 240 


Phe Tyr Ser Thr Ser Lys Ala Asn Ser Phe Gly Phe Asn Pro Leu Val 
                245                 250                 255     


Leu Gly Ser Lys Thr Asn Val Ile Asn Asp Leu Phe Val Ser Lys Pro 
            260                 265                 270         


Phe Thr His Ile Asp Leu Thr Gln Val Thr Leu Gln Asn Ser Asp Asn 
        275                 280                 285             


Ser Ala Ile Asp Ala Asn Lys Leu Lys Gln Ala Val Gly Asp Ile Tyr 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Glu Arg Gln Phe Gln Gly Tyr Phe Ala Gly Gly 
305                 310                 315                 320 


Tyr Ile Asp Lys Tyr Leu Val Lys Asn Val Asn Thr Asn Lys Asp Ser 
                325                 330                 335     


Asp Asp Asp Leu Val Tyr Arg Ser Leu Lys Glu Leu Asn Leu His Leu 
            340                 345                 350         


Glu Glu Ala Tyr Arg Glu Gly Asp Asn Thr Tyr Tyr Arg Val Asn Glu 
        355                 360                 365             


Asn Tyr Tyr Pro Gly Ala Ser Ile Tyr Glu Asn Glu Arg Ala Ser Arg 
    370                 375                 380                 


Asp Ser Glu Phe Gln Asn Glu Ile Leu Lys Arg Ala Glu Gln Asn Gly 
385                 390                 395                 400 


Val Thr Phe Asp Glu Asn 
                405     


<210>  15
<211>  406
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  15

Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln Ser Glu Ile Asp Leu Ser 
1               5                   10                  15      


Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg Asn Phe Ala Asn Glu Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly Leu Asp Arg Pro Val Pro 
        35                  40                  45              


Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr Gly Asp Asn Phe Ile Thr 
    50                  55                  60                  


Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His Val Ala Ser Asp Gly Ser 
65                  70                  75                  80  


Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Leu 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Met Ala Asn Asn Arg 
            100                 105                 110         


Gly Tyr Asp Asp Val Phe Arg Gln Val Pro Ser Phe Ser Gly Trp Ser 
        115                 120                 125             


Asn Thr Lys Ala Thr Thr Val Ser Thr Ser Asn Asn Leu Thr Tyr Asp 
    130                 135                 140                 


Lys Trp Thr Tyr Phe Ala Ala Lys Gly Ser Pro Leu Tyr Asp Ser Tyr 
145                 150                 155                 160 


Pro Asn His Phe Phe Glu Asp Val Lys Thr Leu Ala Ile Asp Ala Lys 
                165                 170                 175     


Asp Ile Ser Ala Leu Lys Thr Thr Ile Asp Ser Glu Lys Pro Thr Tyr 
            180                 185                 190         


Leu Ile Ile Arg Gly Leu Ser Gly Asn Gly Ser Gln Leu Asn Glu Leu 
        195                 200                 205             


Gln Leu Pro Glu Ser Val Lys Lys Val Ser Leu Tyr Gly Asp Tyr Thr 
    210                 215                 220                 


Gly Val Asn Val Ala Lys Gln Ile Phe Ala Asn Val Val Glu Leu Glu 
225                 230                 235                 240 


Phe Tyr Ser Thr Ser Lys Ala Asn Ser Phe Gly Phe Asn Pro Leu Val 
                245                 250                 255     


Leu Gly Ser Lys Thr Asn Val Ile Asn Asp Leu Phe Ala Ser Lys Pro 
            260                 265                 270         


Phe Thr His Ile Asp Leu Thr Gln Val Thr Leu Gln Asn Ser Asp Asn 
        275                 280                 285             


Ser Ala Ile Asp Ala Asn Lys Leu Lys Gln Ala Ile Gly Asp Ile Tyr 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Glu Arg Gln Phe Gln Gly Tyr Phe Ala Gly Gly 
305                 310                 315                 320 


Tyr Ile Asp Lys Tyr Leu Ile Lys Ile Val Asn Thr Asn Pro Asp Val 
                325                 330                 335     


Asp Asp Asp Ile Val Tyr Arg Ser Leu Lys Glu Leu Asn Leu His Leu 
            340                 345                 350         


Glu Glu Ala Tyr Arg Glu Gly Asp Asn Ile Tyr Tyr Arg Val Asn Glu 
        355                 360                 365             


Asn Tyr Tyr Pro Gly Ala Ser Ile Tyr Glu Asn Glu Arg Ala Ser Arg 
    370                 375                 380                 


Asp Ser Glu Phe Gln Asn Glu Ile Leu Lys Arg Ala Glu Gln Asn Gly 
385                 390                 395                 400 


Val Thr Phe Asp Glu Asn 
                405     


<210>  16
<211>  406
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  16

Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln Ser Glu Ile Asp Leu Ser 
1               5                   10                  15      


Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg Asn Phe Ala Asn Glu Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly Leu Asp Arg Pro Val Pro 
        35                  40                  45              


Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr Gly Asp Asn Phe Ile Thr 
    50                  55                  60                  


Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His Val Ala Ser Asp Gly Ser 
65                  70                  75                  80  


Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Leu 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Met Ala Asn Asn Arg 
            100                 105                 110         


Gly Tyr Asp Asp Val Phe Arg Gln Val Pro Ser Phe Ser Gly Trp Ser 
        115                 120                 125             


Asn Thr Lys Pro Thr Thr Val Ser Thr Ser Asn Asn Leu Thr Tyr Asp 
    130                 135                 140                 


Lys Trp Thr Tyr Phe Ala Ala Lys Gly Ser Pro Leu Tyr Asp Ser Tyr 
145                 150                 155                 160 


Pro Asn His Phe Phe Glu Asp Val Lys Thr Leu Ala Ile Asp Ala Lys 
                165                 170                 175     


Asp Ile Ser Ala Leu Lys Thr Thr Ile Asp Ser Glu Lys Pro Thr Tyr 
            180                 185                 190         


Leu Ile Ile Arg Gly Leu Ser Gly Asn Gly Ser Gln Leu Asn Glu Leu 
        195                 200                 205             


Gln Leu Pro Glu Ser Val Lys Lys Val Ser Leu Tyr Gly Asp Tyr Thr 
    210                 215                 220                 


Gly Val Asn Val Ala Lys Gln Ile Phe Ala Asn Val Val Glu Leu Glu 
225                 230                 235                 240 


Phe Tyr Ser Thr Ser Lys Ala Asn Ser Phe Gly Phe Asn Pro Leu Val 
                245                 250                 255     


Leu Gly Ser Lys Thr Asn Val Ile Asn Asp Leu Phe Ala Ser Lys Pro 
            260                 265                 270         


Phe Thr His Ile Asp Leu Thr Gln Val Thr Leu Gln Asn Ser Asp Asn 
        275                 280                 285             


Ser Ala Ile Asp Ala Asn Lys Leu Lys Gln Ala Val Gly Asp Ile Tyr 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Glu Arg Gln Phe Gln Gly Tyr Phe Ala Gly Gly 
305                 310                 315                 320 


Tyr Ile Asp Lys Tyr Leu Val Lys Asn Val Asn Thr Asn Lys Asp Ser 
                325                 330                 335     


Asp Asp Asp Leu Val Tyr Arg Ser Leu Lys Glu Leu Asn Leu His Leu 
            340                 345                 350         


Glu Glu Ala Tyr Arg Glu Gly Asp Asn Thr Tyr Tyr Arg Val Asn Glu 
        355                 360                 365             


Asn Tyr Tyr Pro Gly Ala Ser Ile Tyr Glu Asn Glu Arg Ala Ser Arg 
    370                 375                 380                 


Asp Ser Glu Phe Gln Asn Glu Ile Leu Lys Arg Ala Glu Gln Asn Gly 
385                 390                 395                 400 


Val Thr Phe Asp Glu Asn 
                405     


<210>  17
<211>  406
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  17

Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln Ser Glu Ile Asp Leu Ser 
1               5                   10                  15      


Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg Asn Phe Ala Asn Glu Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly Leu Asp Arg Pro Val Pro 
        35                  40                  45              


Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr Gly Asp Asn Phe Ile Thr 
    50                  55                  60                  


Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His Val Ala Ser Asp Gly Ser 
65                  70                  75                  80  


Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Leu 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Met Ala Asn Asn Arg 
            100                 105                 110         


Gly Tyr Asp Asp Val Phe Arg Gln Val Pro Ser Phe Ser Gly Trp Ser 
        115                 120                 125             


Asn Thr Lys Ala Thr Thr Val Ser Thr Ser Asn Asn Leu Thr Tyr Asp 
    130                 135                 140                 


Lys Trp Thr Tyr Phe Ala Ala Lys Gly Ser Pro Leu Tyr Asp Ser Tyr 
145                 150                 155                 160 


Pro Asn His Phe Phe Glu Asp Val Lys Thr Leu Ala Ile Asp Ala Lys 
                165                 170                 175     


Asp Ile Ser Ala Leu Lys Thr Thr Ile Asp Ser Glu Lys Pro Thr Tyr 
            180                 185                 190         


Leu Ile Ile Arg Gly Leu Ser Gly Asn Gly Ser Gln Leu Asn Glu Leu 
        195                 200                 205             


Gln Leu Pro Glu Ser Val Lys Lys Val Ser Leu Tyr Gly Asp Tyr Thr 
    210                 215                 220                 


Gly Val Asn Val Ala Lys Gln Ile Phe Ala Asn Val Val Glu Leu Glu 
225                 230                 235                 240 


Phe Tyr Ser Thr Ser Lys Ala Asn Ser Phe Gly Phe Asn Pro Leu Val 
                245                 250                 255     


Leu Gly Ser Lys Thr Asn Val Ile Asn Asp Leu Phe Ala Ser Lys Pro 
            260                 265                 270         


Phe Thr His Ile Asp Leu Thr Gln Val Asp Leu Gln Asn Ser Asp Asn 
        275                 280                 285             


Ser Ala Ile Asp Ala Asn Lys Leu Lys Gln Ala Val Gly Asp Ile Tyr 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Glu Arg Gln Phe Gln Gly Tyr Phe Ala Gly Gly 
305                 310                 315                 320 


Tyr Ile Asp Lys Tyr Leu Val Lys Asn Val Asn Thr Asn Lys Asp Ser 
                325                 330                 335     


Asp Asp Asp Leu Val Tyr Arg Ser Leu Lys Glu Leu Asn Leu His Leu 
            340                 345                 350         


Glu Glu Ala Tyr Arg Glu Gly Asp Asn Thr Tyr Tyr Arg Val Asn Glu 
        355                 360                 365             


Asn Tyr Tyr Pro Gly Ala Ser Ile Tyr Glu Asn Glu Arg Ala Ser Arg 
    370                 375                 380                 


Asp Ser Glu Phe Gln Asn Glu Ile Leu Lys Arg Ala Glu Gln Asn Gly 
385                 390                 395                 400 


Val Thr Phe Asp Glu Asn 
                405     


<210>  18
<211>  406
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  18

Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln Ser Glu Ile Asp Leu Ser 
1               5                   10                  15      


Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg Asn Phe Ala Asn Glu Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly Leu Asp Arg Pro Val Pro 
        35                  40                  45              


Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr Gly Asp Asn Phe Ile Thr 
    50                  55                  60                  


Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His Val Ala Ser Asp Gly Ser 
65                  70                  75                  80  


Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Leu 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Met Ala Asn Asn Arg 
            100                 105                 110         


Gly Tyr Asp Asp Val Phe Arg Gln Val Pro Ser Phe Ser Gly Trp Ser 
        115                 120                 125             


Asn Thr Lys Ala Thr Thr Val Ser Thr Ser Asn Asn Leu Thr Tyr Asp 
    130                 135                 140                 


Lys Trp Thr Tyr Phe Ala Ala Lys Gly Ser Pro Leu Tyr Asp Ser Tyr 
145                 150                 155                 160 


Pro Asn His Phe Phe Glu Asp Val Lys Thr Leu Ala Ile Asp Ala Lys 
                165                 170                 175     


Asp Ile Ser Ala Leu Lys Thr Thr Ile Asp Ser Glu Lys Pro Thr Tyr 
            180                 185                 190         


Leu Ile Ile Arg Gly Leu Ser Gly Asn Gly Ser Gln Leu Asn Glu Leu 
        195                 200                 205             


Gln Leu Pro Glu Ser Val Lys Lys Val Ser Leu Tyr Gly Asp Tyr Thr 
    210                 215                 220                 


Gly Val Asn Val Ala Lys Gln Ile Phe Ala Asn Val Val Glu Leu Glu 
225                 230                 235                 240 


Phe Tyr Ser Thr Ser Lys Ala Asn Ser Phe Gly Phe Asn Pro Leu Val 
                245                 250                 255     


Leu Gly Ser Lys Thr Asn Val Ile Asn Asp Leu Phe Ala Ser Lys Pro 
            260                 265                 270         


Phe Thr His Ile Asp Leu Thr Gln Val Pro Leu Gln Asn Ser Asp Asn 
        275                 280                 285             


Ser Ala Ile Asp Ala Asn Lys Leu Lys Gln Ala Val Gly Asp Ile Tyr 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Glu Arg Gln Phe Gln Gly Tyr Phe Ala Gly Gly 
305                 310                 315                 320 


Tyr Ile Asp Lys Tyr Leu Val Lys Asn Val Asn Thr Asn Lys Asp Ser 
                325                 330                 335     


Asp Asp Asp Leu Val Tyr Arg Ser Leu Lys Glu Leu Asn Leu His Leu 
            340                 345                 350         


Glu Glu Ala Tyr Arg Glu Gly Asp Asn Thr Tyr Tyr Arg Val Asn Glu 
        355                 360                 365             


Asn Tyr Tyr Pro Gly Ala Ser Ile Tyr Glu Asn Glu Arg Ala Ser Arg 
    370                 375                 380                 


Asp Ser Glu Phe Gln Asn Glu Ile Leu Lys Arg Ala Glu Gln Asn Gly 
385                 390                 395                 400 


Val Thr Phe Asp Glu Asn 
                405     


<210>  19
<211>  406
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  19

Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln Ser Glu Ile Asp Leu Ser 
1               5                   10                  15      


Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg Asn Phe Ala Asn Glu Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly Leu Asp Arg Pro Val Pro 
        35                  40                  45              


Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr Gly Asp Asn Phe Ile Thr 
    50                  55                  60                  


Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His Val Ala Glu Asp Gly Ser 
65                  70                  75                  80  


Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Leu 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Met Ala Asn Asn Arg 
            100                 105                 110         


Gly Tyr Asp Asp Val Phe Arg Gln Val Pro Arg Phe Pro Gly Trp Ser 
        115                 120                 125             


Asn Thr Lys Ala Thr Thr Val Ser Thr Ser Asn Asn Leu Thr Tyr Asp 
    130                 135                 140                 


Lys Trp Thr Tyr Phe Ala Ala Lys Gly Ser Pro Leu Tyr Asp Ser Tyr 
145                 150                 155                 160 


Pro Asn His Phe Phe Glu Asp Val Lys Thr Leu Ala Ile Asp Ala Lys 
                165                 170                 175     


Asp Ile Ser Ala Leu Lys Thr Thr Ile Asp Ser Glu Lys Pro Thr Tyr 
            180                 185                 190         


Leu Ile Ile Arg Gly Leu Ser Gly Asn Gly Ser Gln Leu Asn Glu Leu 
        195                 200                 205             


Gln Leu Pro Glu Ser Val Lys Lys Val Ser Leu Tyr Gly Asp Tyr Thr 
    210                 215                 220                 


Gly Val Asn Val Ala Lys Gln Ile Phe Ala Asn Val Val Glu Leu Glu 
225                 230                 235                 240 


Phe Tyr Ser Thr Ser Lys Ala Asn Ser Phe Gly Phe Asn Pro Leu Val 
                245                 250                 255     


Leu Gly Ser Lys Thr Asn Val Ile Asn Asp Leu Phe Val Ser Lys Pro 
            260                 265                 270         


Phe Thr His Ile Asp Leu Thr Gln Val Thr Leu Gln Asn Ser Asp Asn 
        275                 280                 285             


Ser Ala Ile Asp Ala Asn Lys Leu Lys Gln Ala Ile Gly Asp Ile Tyr 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Glu Arg Gln Phe Gln Gly Tyr Phe Ala Gly Gly 
305                 310                 315                 320 


Tyr Ile Asp Lys Tyr Leu Ile Lys Asn Val Asn Thr Asn Lys Asp Ser 
                325                 330                 335     


Asp Asp Asp Leu Val Tyr Arg Ser Leu Lys Glu Leu Asn Leu His Leu 
            340                 345                 350         


Glu Glu Ala Tyr Arg Glu Gly Asp Asn Thr Tyr Tyr Arg Val Asn Glu 
        355                 360                 365             


Asn Tyr Tyr Pro Gly Ala Ser Ile Tyr Glu Asn Glu Arg Ala Ser Arg 
    370                 375                 380                 


Asp Ser Glu Phe Gln Asn Glu Ile Leu Lys Arg Ala Glu Gln Asn Gly 
385                 390                 395                 400 


Val Thr Phe Asp Glu Asn 
                405     


<210>  20
<211>  406
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  20

Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln Ser Glu Ile Asp Leu Ser 
1               5                   10                  15      


Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg Asn Phe Ala Asn Glu Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly Leu Asp Arg Pro Val Pro 
        35                  40                  45              


Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr Gly Asp Asn Phe Ile Thr 
    50                  55                  60                  


Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His Val Ala Glu Asp Gly Ser 
65                  70                  75                  80  


Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Leu 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Met Ala Asn Asn Arg 
            100                 105                 110         


Gly Tyr Asp Asp Val Phe Arg Gln Val Pro Arg Phe Pro Gly Trp Ser 
        115                 120                 125             


Asn Thr Lys Ala Thr Thr Val Ser Thr Ser Asn Asn Leu Thr Tyr Asp 
    130                 135                 140                 


Lys Trp Thr Tyr Phe Ala Ala Lys Gly Ser Pro Leu Tyr Asp Gln Tyr 
145                 150                 155                 160 


Pro Asn His Thr Phe Glu Asp Val Lys Thr Leu Ala Ile Asp Ala Lys 
                165                 170                 175     


Asp Ile Ser Ala Leu Lys Thr Thr Ile Asp Ser Glu Lys Pro Thr Tyr 
            180                 185                 190         


Leu Ile Ile Arg Gly Leu Ser Gly Asn Gly Ser Gln Leu Asn Glu Leu 
        195                 200                 205             


Gln Leu Pro Glu Ser Val Lys Lys Val Ser Leu Tyr Gly Asp Tyr Thr 
    210                 215                 220                 


Gly Val Asn Val Ala Lys Gln Ile Phe Ala Asn Val Val Glu Leu Glu 
225                 230                 235                 240 


Phe Tyr Ser Thr Ser Lys Ala Asn Ser Phe Gly Phe Asn Pro Leu Val 
                245                 250                 255     


Leu Gly Ser Lys Thr Asn Val Ile Asn Asp Leu Phe Val Ser Lys Pro 
            260                 265                 270         


Phe Thr His Ile Asp Leu Thr Gln Val Thr Leu Gln Asn Ser Asp Asn 
        275                 280                 285             


Ser Ala Ile Asp Ala Asn Lys Leu Lys Gln Ala Ile Gly Asp Ile Tyr 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Glu Arg Gln Phe Gln Gly Tyr Phe Ala Gly Gly 
305                 310                 315                 320 


Tyr Ile Asp Lys Tyr Leu Ile Lys Asn Val Asn Thr Asn Lys Asp Ser 
                325                 330                 335     


Asp Asp Asp Leu Val Tyr Arg Ser Leu Lys Glu Leu Asn Leu His Leu 
            340                 345                 350         


Glu Glu Ala Tyr Arg Glu Gly Asp Asn Thr Tyr Tyr Arg Val Asn Glu 
        355                 360                 365             


Asn Tyr Tyr Pro Gly Ala Ser Ile Tyr Glu Asn Glu Arg Ala Ser Arg 
    370                 375                 380                 


Asp Ser Glu Phe Gln Asn Glu Ile Leu Lys Arg Ala Glu Gln Asn Gly 
385                 390                 395                 400 


Val Thr Phe Asp Glu Asn 
                405     


<210>  21
<211>  406
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  21

Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln Ser Glu Ile Asp Leu Ser 
1               5                   10                  15      


Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg Asn Phe Ala Asn Glu Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly Leu Asp Arg Pro Val Pro 
        35                  40                  45              


Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr Gly Asp Asn Phe Ile Thr 
    50                  55                  60                  


Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His Val Ala Ser Asp Gly Ser 
65                  70                  75                  80  


Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Leu 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Met Ala Asn Asn Arg 
            100                 105                 110         


Gly Tyr Asp Asp Val Phe Arg Gln Val Pro Ser Phe Ser Gly Trp Cys 
        115                 120                 125             


Asn Thr Lys Ala Thr Thr Val Ser Thr Ser Asn Asn Leu Thr Tyr Asp 
    130                 135                 140                 


Lys Trp Thr Tyr Phe Ala Cys Lys Gly Ser Pro Leu Tyr Asp Ser Tyr 
145                 150                 155                 160 


Pro Asn His Phe Phe Glu Asp Val Lys Thr Leu Ala Ile Asp Ala Lys 
                165                 170                 175     


Asp Ile Ser Ala Leu Lys Thr Thr Ile Asp Ser Glu Lys Pro Thr Tyr 
            180                 185                 190         


Leu Ile Ile Arg Gly Leu Ser Gly Asn Gly Ser Gln Leu Asn Glu Leu 
        195                 200                 205             


Gln Leu Pro Glu Ser Val Lys Lys Val Ser Leu Tyr Gly Asp Tyr Thr 
    210                 215                 220                 


Gly Val Asn Val Ala Lys Gln Ile Phe Ala Asn Val Val Glu Leu Glu 
225                 230                 235                 240 


Phe Tyr Ser Thr Ser Lys Ala Asn Ser Phe Gly Phe Asn Pro Leu Val 
                245                 250                 255     


Leu Gly Ser Lys Thr Asn Val Ile Asn Asp Leu Phe Ala Ser Lys Pro 
            260                 265                 270         


Phe Thr His Ile Asp Leu Thr Gln Val Thr Leu Gln Asn Ser Asp Asn 
        275                 280                 285             


Ser Ala Ile Asp Ala Asn Lys Leu Lys Gln Ala Val Gly Asp Ile Tyr 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Glu Arg Gln Phe Gln Gly Tyr Phe Ala Gly Gly 
305                 310                 315                 320 


Tyr Ile Asp Lys Tyr Leu Val Lys Asn Val Asn Thr Asn Lys Asp Ser 
                325                 330                 335     


Asp Asp Asp Leu Val Tyr Arg Ser Leu Lys Glu Leu Asn Leu His Leu 
            340                 345                 350         


Glu Glu Ala Tyr Arg Glu Gly Asp Asn Thr Tyr Tyr Arg Val Asn Glu 
        355                 360                 365             


Asn Tyr Tyr Pro Gly Ala Ser Ile Tyr Glu Asn Glu Arg Ala Ser Arg 
    370                 375                 380                 


Asp Ser Glu Phe Gln Asn Glu Ile Leu Lys Arg Ala Glu Gln Asn Gly 
385                 390                 395                 400 


Val Thr Phe Asp Glu Asn 
                405     


<210>  22
<211>  406
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  22

Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln Ser Glu Ile Asp Leu Ser 
1               5                   10                  15      


Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg Asn Phe Ala Asn Glu Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly Leu Asp Arg Pro Val Pro 
        35                  40                  45              


Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr Gly Asp Asn Phe Ile Thr 
    50                  55                  60                  


Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His Val Ala Glu Asp Gly Ser 
65                  70                  75                  80  


Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Leu 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Met Ala Asn Asn Arg 
            100                 105                 110         


Gly Tyr Asp Asp Val Phe Arg Gln Val Pro Arg Phe Pro Gly Trp Cys 
        115                 120                 125             


Asn Thr Lys Ala Thr Thr Val Ser Thr Ser Asn Asn Leu Thr Tyr Asp 
    130                 135                 140                 


Lys Trp Thr Tyr Phe Ala Cys Lys Gly Ser Pro Leu Tyr Asp Gln Tyr 
145                 150                 155                 160 


Pro Asn His Thr Phe Glu Asp Val Lys Thr Leu Ala Ile Asp Ala Lys 
                165                 170                 175     


Asp Ile Ser Ala Leu Lys Thr Thr Ile Asp Ser Glu Lys Pro Thr Tyr 
            180                 185                 190         


Leu Ile Ile Arg Gly Leu Ser Gly Asn Gly Ser Gln Leu Asn Glu Leu 
        195                 200                 205             


Gln Leu Pro Glu Ser Val Lys Lys Val Ser Leu Tyr Gly Asp Tyr Thr 
    210                 215                 220                 


Gly Val Asn Val Ala Lys Gln Ile Phe Ala Asn Val Val Glu Leu Glu 
225                 230                 235                 240 


Phe Tyr Ser Thr Ser Lys Ala Asn Ser Phe Gly Phe Asn Pro Leu Val 
                245                 250                 255     


Leu Gly Ser Lys Thr Asn Val Ile Asn Asp Leu Phe Val Ser Lys Pro 
            260                 265                 270         


Phe Thr His Ile Asp Leu Thr Gln Val Thr Leu Gln Asn Ser Asp Asn 
        275                 280                 285             


Ser Ala Ile Asp Ala Asn Lys Leu Lys Gln Ala Val Gly Asp Ile Tyr 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Glu Arg Gln Phe Gln Gly Tyr Phe Ala Gly Gly 
305                 310                 315                 320 


Tyr Ile Asp Lys Tyr Leu Val Lys Asn Val Asn Thr Asn Lys Asp Ser 
                325                 330                 335     


Asp Asp Asp Leu Val Tyr Arg Ser Leu Lys Glu Leu Asn Leu His Leu 
            340                 345                 350         


Glu Glu Ala Tyr Arg Glu Gly Asp Asn Thr Tyr Tyr Arg Val Asn Glu 
        355                 360                 365             


Asn Tyr Tyr Pro Gly Ala Ser Ile Tyr Glu Asn Glu Arg Ala Ser Arg 
    370                 375                 380                 


Asp Ser Glu Phe Gln Asn Glu Ile Leu Lys Arg Ala Glu Gln Asn Gly 
385                 390                 395                 400 


Val Thr Phe Asp Glu Asn 
                405     


<210>  23
<211>  582
<212>  PRT
<213>  Mycoplasma pneumoniae

<400>  23

Met Lys Leu Asn Phe Lys Ile Lys Asp Lys Lys Thr Leu Lys Arg Leu 
1               5                   10                  15      


Lys Lys Gly Gly Phe Trp Ala Leu Gly Leu Phe Gly Ala Ala Ile Asn 
            20                  25                  30          


Ala Phe Ser Ala Val Leu Ile Val Asn Glu Val Leu Arg Leu Gln Ser 
        35                  40                  45              


Gly Glu Thr Leu Ile Ala Ser Gly Arg Ser Gly Asn Leu Ser Phe Gln 
    50                  55                  60                  


Leu Tyr Ser Lys Val Asn Gln Asn Ala Lys Ser Lys Leu Asn Ser Ile 
65                  70                  75                  80  


Ser Leu Thr Asp Gly Gly Tyr Arg Ser Glu Ile Asp Leu Gly Asp Gly 
                85                  90                  95      


Ser Asn Phe Arg Glu Asp Phe Arg Asn Phe Ala Asn Asn Leu Ser Glu 
            100                 105                 110         


Ala Ile Thr Asp Ala Pro Lys Asp Leu Leu Arg Pro Val Pro Lys Val 
        115                 120                 125             


Glu Val Ser Gly Leu Ile Lys Thr Ser Ser Thr Phe Ile Thr Pro Asn 
    130                 135                 140                 


Phe Lys Ala Gly Tyr Tyr Asp Gln Val Ala Ala Asp Gly Lys Thr Leu 
145                 150                 155                 160 


Lys Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Val Met Pro 
                165                 170                 175     


Ile Leu Gln Thr Thr Asn Gly Thr Leu Thr Ala Asn Asn Arg Ala Tyr 
            180                 185                 190         


Asp Asp Ile Phe Val Asp Gln Gly Val Pro Lys Phe Pro Gly Trp Phe 
        195                 200                 205             


His Asp Val Asp Lys Ala Tyr Tyr Ala Gly Ser Asn Gly Gln Ser Glu 
    210                 215                 220                 


Tyr Leu Phe Lys Glu Trp Asn Tyr Tyr Val Ala Asn Gly Ser Pro Leu 
225                 230                 235                 240 


Tyr Asn Val Tyr Pro Asn His His Phe Lys Gln Ile Lys Thr Ile Ala 
                245                 250                 255     


Phe Asp Ala Pro Arg Ile Lys Gln Gly Asn Thr Asp Gly Ile Asn Leu 
            260                 265                 270         


Asn Leu Lys Gln Arg Asn Pro Asp Tyr Val Ile Ile Asn Gly Leu Thr 
        275                 280                 285             


Gly Asp Gly Ser Thr Leu Lys Asp Leu Glu Leu Pro Glu Ser Val Lys 
    290                 295                 300                 


Lys Val Ser Ile Tyr Gly Asp Tyr His Ser Ile Asn Val Ala Lys Gln 
305                 310                 315                 320 


Ile Phe Lys Asn Val Leu Glu Leu Glu Phe Tyr Ser Thr Asn Gln Asp 
                325                 330                 335     


Asn Asn Phe Gly Phe Asn Pro Leu Val Leu Gly Asp His Thr Asn Ile 
            340                 345                 350         


Ile Tyr Asp Leu Phe Ala Ser Lys Pro Phe Asn Tyr Ile Asp Leu Thr 
        355                 360                 365             


Ser Leu Glu Leu Lys Asp Asn Gln Asp Asn Ile Asp Ala Ser Lys Leu 
    370                 375                 380                 


Lys Arg Ala Val Ser Asp Ile Tyr Ile Arg Arg Arg Phe Glu Arg Gln 
385                 390                 395                 400 


Met Gln Gly Tyr Trp Ala Gly Gly Tyr Ile Asp Arg Tyr Leu Val Lys 
                405                 410                 415     


Asn Thr Asn Glu Lys Asn Val Asn Lys Asp Asn Asp Thr Val Tyr Ala 
            420                 425                 430         


Ala Leu Lys Asp Ile Asn Leu His Leu Glu Glu Thr Tyr Thr His Gly 
        435                 440                 445             


Gly Asn Thr Met Tyr Arg Val Asn Glu Asn Tyr Tyr Pro Gly Ala Ser 
    450                 455                 460                 


Ala Tyr Glu Ala Glu Arg Ala Thr Arg Asp Ser Glu Phe Gln Lys Glu 
465                 470                 475                 480 


Ile Val Gln Arg Ala Glu Leu Ile Gly Val Val Phe Glu Tyr Gly Val 
                485                 490                 495     


Lys Asn Leu Arg Pro Gly Leu Lys Tyr Thr Val Lys Phe Glu Ser Pro 
            500                 505                 510         


Gln Glu Gln Val Ala Leu Lys Ser Thr Asp Lys Phe Gln Pro Val Ile 
        515                 520                 525             


Gly Ser Val Thr Asp Met Ser Lys Ser Val Thr Asp Leu Ile Gly Val 
    530                 535                 540                 


Leu Arg Asp Asn Ala Glu Ile Leu Asn Ile Thr Asn Val Ser Lys Asp 
545                 550                 555                 560 


Glu Thr Val Val Ala Glu Leu Lys Glu Lys Leu Asp Arg Glu Asn Val 
                565                 570                 575     


Phe Gln Glu Ile Arg Thr 
            580         


<210>  24
<211>  415
<212>  PRT
<213>  Mycoplasma pneumoniae

<400>  24

Ser Ile Ser Leu Thr Asp Gly Gly Tyr Arg Ser Glu Ile Asp Leu Gly 
1               5                   10                  15      


Asp Gly Ser Asn Phe Arg Glu Asp Phe Arg Asn Phe Ala Asn Asn Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asp Ala Pro Lys Asp Leu Leu Arg Pro Val Pro 
        35                  40                  45              


Lys Val Glu Val Ser Gly Leu Ile Lys Thr Ser Ser Thr Phe Ile Thr 
    50                  55                  60                  


Pro Asn Phe Lys Ala Gly Tyr Tyr Asp Gln Val Ala Ala Asp Gly Lys 
65                  70                  75                  80  


Thr Leu Lys Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Val 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Thr Ala Asn Asn Arg 
            100                 105                 110         


Ala Tyr Asp Asp Ile Phe Val Asp Gln Gly Val Pro Lys Phe Pro Gly 
        115                 120                 125             


Trp Phe His Asp Val Asp Lys Ala Tyr Tyr Ala Gly Ser Asn Gly Gln 
    130                 135                 140                 


Ser Glu Tyr Leu Phe Lys Glu Trp Asn Tyr Tyr Val Ala Asn Gly Ser 
145                 150                 155                 160 


Pro Leu Tyr Asn Val Tyr Pro Asn His His Phe Lys Gln Ile Lys Thr 
                165                 170                 175     


Ile Ala Phe Asp Ala Pro Arg Ile Lys Gln Gly Asn Thr Asp Gly Ile 
            180                 185                 190         


Asn Leu Asn Leu Lys Gln Arg Asn Pro Asp Tyr Val Ile Ile Asn Gly 
        195                 200                 205             


Leu Thr Gly Asp Gly Ser Thr Leu Lys Asp Leu Glu Leu Pro Glu Ser 
    210                 215                 220                 


Val Lys Lys Val Ser Ile Tyr Gly Asp Tyr His Ser Ile Asn Val Ala 
225                 230                 235                 240 


Lys Gln Ile Phe Lys Asn Val Leu Glu Leu Glu Phe Tyr Ser Thr Asn 
                245                 250                 255     


Gln Asp Asn Asn Phe Gly Phe Asn Pro Leu Val Leu Gly Asp His Thr 
            260                 265                 270         


Asn Ile Ile Tyr Asp Leu Phe Ala Ser Lys Pro Phe Asn Tyr Ile Asp 
        275                 280                 285             


Leu Thr Ser Leu Glu Leu Lys Asp Asn Gln Asp Asn Ile Asp Ala Ser 
    290                 295                 300                 


Lys Leu Lys Arg Ala Val Ser Asp Ile Tyr Ile Arg Arg Arg Phe Glu 
305                 310                 315                 320 


Arg Gln Met Gln Gly Tyr Trp Ala Gly Gly Tyr Ile Asp Arg Tyr Leu 
                325                 330                 335     


Val Lys Asn Thr Asn Glu Lys Asn Val Asn Lys Asp Asn Asp Thr Val 
            340                 345                 350         


Tyr Ala Ala Leu Lys Asp Ile Asn Leu His Leu Glu Glu Thr Tyr Thr 
        355                 360                 365             


His Gly Gly Asn Thr Met Tyr Arg Val Asn Glu Asn Tyr Tyr Pro Gly 
    370                 375                 380                 


Ala Ser Ala Tyr Glu Ala Glu Arg Ala Thr Arg Asp Ser Glu Phe Gln 
385                 390                 395                 400 


Lys Glu Ile Val Gln Arg Ala Glu Leu Ile Gly Val Val Phe Glu 
                405                 410                 415 


<210>  25
<211>  1287
<212>  DNA
<213>  Artificial

<220>
<223>  codon-optimized polynucleotide

<400>  25
atgggcagca gccatcacca tcatcatcac agcagcggtc tggtgccgcg tggtagccac       60

atgagcctga gcctgaacga tggtagctac cagagcgaga tcgacctgag cggcggtgcc      120

aacttccgtg aaaaattccg caactttgct aacgagctga gcgaagccat taccaatagc      180

ccaaagggcc tggatcgtcc agtgccgaaa accgagatca gcggcctgat taagaccggt      240

gacaacttta tcaccccgag cttcaaggcg ggctactatg atcacgtggc tgaggacggt      300

agcctgctga gctactatca gagcaccgag tactttaaca accgtgtgct gatgccgatt      360

ctgcagacca ccaacggcac cctgatggcc aacaaccgtg gttatgacga cgtgttccgt      420

caggtgccgc gtttcccggg ctggagcaac accaaagcga ccaccgtgag caccagcaac      480

aacctgacct acgacaagtg gacctatttc gccgcgaaag gtagcccgct gtacgatcag      540

tatccgaacc acacctttga ggacgtgaaa accctggcta tcgatgccaa ggacattagc      600

gcgctgaaaa ccaccatcga tagcgaaaag ccgacctacc tgatcattcg cggtctgagc      660

ggcaacggta gccagctgaa cgagctgcag ctgccggaaa gcgtgaagaa agtgagcctg      720

tacggcgact ataccggtgt gaacgtggcc aaacagattt ttgcgaacgt ggtggagctg      780

gaattctata gcaccagcaa ggcgaacagc ttcggcttta acccgctggt gctgggtagc      840

aaaaccaacg tgatcaacga cctgttcgtg agcaagccgt tcacccacat tgacctgacc      900

caggtgaccc tgcagaacag cgataacagc gcgatcgacg ctaacaagct gaaacaggct      960

gtgggcgata tctacaacta tcgtcgcttc gagcgtcagt ttcagggtta cttcgccggc     1020

ggttacatcg ataagtatct ggtgaaaaac gtgaacacca acaaagacag cgacgatgac     1080

ctggtgtacc gcagcctgaa ggaactgaac ctgcacctgg aggaagctta tcgtgagggc     1140

gacaacacct actatcgcgt gaacgaaaac tactatccgg gtgccagcat ctacgagaac     1200

gaacgtgcga gccgcgatag cgagtttcag aacgaaattc tgaagcgtgc ggagcagaac     1260

ggcgtgacct tcgacgaaaa ctaataa                                         1287


<210>  26
<211>  1227
<212>  DNA
<213>  Artificial

<220>
<223>  codon-optimized polynucleotide

<400>  26
atgagcctga gcctgaacga tggcagctac cagagcgaga tcgacctgtc tggcggagcc       60

aacttcagag agaagttcag aaacttcgcc aacgagctga gcgaggccat cacaaacagc      120

cccaaaggcc tggacagacc cgtgcctaag acagagatca gcggcctgat caagaccggc      180

gacaacttca tcacccctag cttcaaggcc ggctactacg atcacgtggc ctctgatggc      240

agcctgctga gctactacca gtccaccgag tacttcaaca accgggtgct gatgcccatc      300

ctccagacca ccaatggcac cctgatggcc aacaacagag gctacgacga cgtgttcaga      360

caggtgccca gctttagcgg ctggtccaat accaaggcca ccaccgtgtc caccagcaac      420

aacctgacct acgacaagtg gacctacttc gccgccaagg gcagccctct gtacgacagc      480

taccccaacc acttcttcga ggacgtgaaa accctggcca tcgacgccaa ggatatcagc      540

gccctgaaaa ccaccatcga cagcgagaag cccacctacc tgatcatcag aggactgagc      600

ggcaacggca gccagctgaa tgaactccag ctgcctgaga gcgtgaagaa ggtgtccctg      660

tacggcgatt acaccggcgt gaacgtggcc aagcagatct tcgccaatgt ggtggaactg      720

gaattctaca gcaccagcaa ggccaacagc ttcggcttca accctctggt gctgggcagc      780

aagaccaacg tgatcaacga cctgttcgcc agcaagccct tcacacacat cgatctgacc      840

caagtgaccc tccagaacag cgacaacagc gccattgatg ccaacaagct gaaacaggcc      900

gtgggcgaca tctacaacta cagaagattc gagcggcagt tccagggcta cttcgctggc      960

ggctacatcg acaagtacct ggtcaagaac gtgaacacca acaaggacag cgacgacgac     1020

ctggtgtaca gaagcctgaa agagctgaac ctgcacctgg aagaggccta cagagagggc     1080

gacaacacct actacagagt gaacgagaac tactacccag gcgccagcat ctacgagaac     1140

gagagagcca gcagagacag cgagttccag aacgagatcc tgaagcgggc cgagcagaat     1200

ggcgtgacct tcgacgagaa ctgatga                                         1227


<210>  27
<211>  406
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  27

Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln Ser Glu Ile Asp Leu Ser 
1               5                   10                  15      


Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg Asn Phe Ala Asn Glu Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly Leu Asp Arg Pro Val Pro 
        35                  40                  45              


Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr Gly Asp Asn Phe Ile Thr 
    50                  55                  60                  


Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His Val Ala Glu Asp Gly Ser 
65                  70                  75                  80  


Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Leu 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Met Ala Asn Asn Arg 
            100                 105                 110         


Gly Tyr Asp Asp Val Phe Arg Gln Val Pro Arg Phe Pro Gly Trp Ser 
        115                 120                 125             


Asn Thr Lys Ala Thr Thr Val Ser Thr Ser Asn Asn Leu Thr Tyr Asp 
    130                 135                 140                 


Lys Trp Thr Tyr Phe Ala Ala Lys Gly Ser Pro Leu Tyr Asp Gln Tyr 
145                 150                 155                 160 


Pro Asn His Thr Phe Glu Asp Val Lys Thr Leu Ala Ile Asp Ala Lys 
                165                 170                 175     


Asp Ile Ser Ala Leu Lys Thr Thr Ile Asp Ser Glu Lys Pro Thr Tyr 
            180                 185                 190         


Leu Ile Ile Arg Gly Leu Ser Gly Asn Gly Ser Gln Leu Asn Glu Leu 
        195                 200                 205             


Gln Leu Pro Glu Ser Val Lys Lys Val Ser Leu Tyr Gly Asp Tyr Thr 
    210                 215                 220                 


Gly Val Asn Val Ala Lys Gln Ile Phe Ala Asn Val Val Glu Leu Glu 
225                 230                 235                 240 


Phe Tyr Ser Thr Ser Lys Ala Asn Ser Phe Gly Phe Asn Pro Leu Val 
                245                 250                 255     


Leu Gly Ser Lys Thr Asn Val Ile Asn Asp Leu Phe Val Ser Lys Pro 
            260                 265                 270         


Phe Thr His Ile Asp Leu Thr Gln Val Thr Leu Gln Asn Ser Asp Asn 
        275                 280                 285             


Ser Ala Ile Asp Ala Asn Lys Leu Lys Gln Ala Val Gly Asp Ile Tyr 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Glu Arg Gln Phe Gln Gly Tyr Glu Ala Gly Gly 
305                 310                 315                 320 


Tyr Ile Asp Lys Tyr Leu Val Lys Asn Val Asn Thr Asn Lys Asp Ser 
                325                 330                 335     


Asp Asp Asp Leu Val Tyr Arg Ser Leu Lys Glu Leu Asn Leu His Leu 
            340                 345                 350         


Glu Glu Ala Tyr Arg Glu Gly Asp Asn Thr Tyr Tyr Arg Val Asn Glu 
        355                 360                 365             


Asn Tyr Lys Pro Gly Ala Ser Ile Tyr Glu Asn Glu Arg Ala Ser Arg 
    370                 375                 380                 


Asp Ser Glu Phe Gln Asn Glu Ile Leu Lys Arg Ala Glu Gln Asn Gly 
385                 390                 395                 400 


Val Thr Phe Asp Glu Asn 
                405     


<210>  28
<211>  406
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  28

Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln Ser Glu Ile Asp Leu Ser 
1               5                   10                  15      


Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg Asn Phe Ala Asn Glu Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly Leu Asp Arg Pro Val Pro 
        35                  40                  45              


Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr Gly Asp Asn Phe Ile Thr 
    50                  55                  60                  


Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His Val Ala Glu Asp Gly Ser 
65                  70                  75                  80  


Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Leu 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Met Ala Asn Asn Arg 
            100                 105                 110         


Gly Tyr Asp Asp Val Phe Arg Gln Val Pro Arg Phe Pro Gly Trp Cys 
        115                 120                 125             


Asn Thr Lys Pro Thr Thr Val Ser Thr Ser Asn Asn Leu Thr Tyr Asp 
    130                 135                 140                 


Lys Trp Thr Tyr Phe Ala Cys Lys Gly Ser Pro Leu Tyr Asp Gln Tyr 
145                 150                 155                 160 


Pro Asn His Thr Phe Glu Asp Val Lys Thr Leu Ala Ile Asp Ala Lys 
                165                 170                 175     


Asp Ile Ser Ala Leu Lys Thr Thr Ile Asp Ser Glu Lys Pro Thr Tyr 
            180                 185                 190         


Leu Ile Ile Arg Gly Leu Ser Gly Asp Gly Ser Gln Leu Asn Glu Leu 
        195                 200                 205             


Gln Leu Pro Glu Ser Val Lys Lys Val Ser Leu Tyr Gly Asp Tyr Thr 
    210                 215                 220                 


Gly Val Asn Val Ala Lys Gln Ile Phe Ala Asn Val Val Glu Leu Glu 
225                 230                 235                 240 


Phe Tyr Ser Thr Ser Lys Ala Asn Ser Phe Gly Phe Asn Pro Leu Val 
                245                 250                 255     


Leu Gly Ser Lys Thr Asn Val Ile Asn Asp Leu Phe Val Ser Lys Pro 
            260                 265                 270         


Phe Thr His Ile Asp Leu Thr Gln Val Pro Leu Gln Asn Ser Asp Asn 
        275                 280                 285             


Ser Ala Ile Asp Ala Asn Lys Leu Lys Gln Ala Val Gly Asp Ile Tyr 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Glu Arg Gln Phe Gln Gly Tyr Phe Ala Gly Gly 
305                 310                 315                 320 


Tyr Ile Asp Lys Tyr Leu Val Lys Asn Val Asn Thr Asn Lys Asp Ser 
                325                 330                 335     


Asp Asp Asp Leu Val Tyr Arg Ser Leu Lys Glu Leu Asn Leu His Leu 
            340                 345                 350         


Glu Glu Ala Tyr Arg Glu Gly Asp Asn Thr Tyr Tyr Arg Val Asn Glu 
        355                 360                 365             


Asn Tyr Tyr Pro Gly Ala Ser Ile Tyr Glu Asn Glu Arg Ala Ser Arg 
    370                 375                 380                 


Asp Ser Glu Phe Gln Asn Glu Ile Leu Lys Arg Ala Glu Gln Asn Gly 
385                 390                 395                 400 


Val Thr Phe Asp Glu Asn 
                405     


<210>  29
<211>  406
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  29

Ser Leu Ser Leu Asn Asp Gly Ser Tyr Gln Ser Glu Ile Asp Leu Ser 
1               5                   10                  15      


Gly Gly Ala Asn Phe Arg Glu Lys Phe Arg Asn Phe Ala Asn Glu Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asn Ser Pro Lys Gly Leu Asp Arg Pro Val Pro 
        35                  40                  45              


Lys Thr Glu Ile Ser Gly Leu Ile Lys Thr Gly Asp Asn Phe Ile Thr 
    50                  55                  60                  


Pro Ser Phe Lys Ala Gly Tyr Tyr Asp His Val Ala Glu Asp Gly Ser 
65                  70                  75                  80  


Leu Leu Ser Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Leu 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Met Ala Asn Asn Arg 
            100                 105                 110         


Gly Tyr Asp Asp Val Phe Arg Gln Val Pro Arg Phe Pro Gly Trp Ser 
        115                 120                 125             


Asn Thr Lys Ala Thr Thr Val Ser Thr Ser Asn Asn Leu Thr Tyr Asp 
    130                 135                 140                 


Lys Trp Thr Tyr Phe Ala Ala Lys Gly Ser Pro Leu Tyr Asp Gln Tyr 
145                 150                 155                 160 


Pro Asn His Thr Phe Glu Asp Val Lys Thr Leu Ala Ile Asp Ala Lys 
                165                 170                 175     


Asp Ile Ser Ala Leu Lys Thr Thr Ile Asp Ser Glu Lys Pro Thr Tyr 
            180                 185                 190         


Leu Ile Ile Arg Gly Leu Ser Gly Asn Gly Ser Gln Leu Asn Glu Leu 
        195                 200                 205             


Gln Leu Pro Glu Ser Val Lys Lys Val Ser Leu Tyr Gly Asp Tyr Thr 
    210                 215                 220                 


Gly Val Asn Val Ala Lys Gln Ile Phe Ala Asn Val Val Glu Leu Glu 
225                 230                 235                 240 


Phe Tyr Ser Thr Ser Lys Ala Asn Ser Phe Gly Phe Asn Pro Leu Val 
                245                 250                 255     


Leu Gly Ser Lys Thr Asn Val Ile Asn Asp Leu Phe Val Ser Lys Pro 
            260                 265                 270         


Phe Thr His Ile Asp Leu Thr Gln Val Thr Leu Gln Asn Ser Asp Asn 
        275                 280                 285             


Ser Ala Ile Asp Ala Asn Lys Leu Lys Gln Ala Val Gly Asp Ile Tyr 
    290                 295                 300                 


Asn Tyr Arg Arg Phe Glu Arg Gln Phe Gln Gly Tyr Phe Pro Gly Gly 
305                 310                 315                 320 


Tyr Ile Asp Lys Tyr Leu Val Lys Asn Val Asn Thr Asn Lys Asp Ser 
                325                 330                 335     


Asp Asp Asp Leu Val Tyr Arg Ser Leu Lys Glu Leu Asn Leu His Leu 
            340                 345                 350         


Glu Glu Ala Tyr Arg Glu Gly Asp Asn Thr Tyr Tyr Arg Val Asn Glu 
        355                 360                 365             


Asn Tyr Tyr Pro Gly Ala Ser Ile Tyr Glu Asn Glu Arg Ala Ser Arg 
    370                 375                 380                 


Asp Ser Glu Phe Gln Asn Glu Ile Leu Lys Arg Ala Glu Gln Asn Gly 
385                 390                 395                 400 


Val Thr Phe Asp Glu Asn 
                405     


<210>  30
<211>  406
<212>  PRT
<213>  Artificial

<220>
<223>  modified protein M

<400>  30

Ser Ile Ser Leu Thr Asp Gly Gly Tyr Arg Ser Glu Ile Asp Leu Gly 
1               5                   10                  15      


Asp Gly Ser Asn Phe Arg Glu Asp Phe Arg Asn Phe Ala Asn Asn Leu 
            20                  25                  30          


Ser Glu Ala Ile Thr Asp Ala Pro Lys Asp Leu Leu Arg Pro Val Pro 
        35                  40                  45              


Lys Val Glu Val Ser Gly Leu Ile Lys Thr Ser Ser Thr Phe Ile Thr 
    50                  55                  60                  


Pro Asn Phe Lys Ala Gly Tyr Tyr Asp Gln Val Ala Glu Asp Gly Lys 
65                  70                  75                  80  


Thr Leu Lys Tyr Tyr Gln Ser Thr Glu Tyr Phe Asn Asn Arg Val Val 
                85                  90                  95      


Met Pro Ile Leu Gln Thr Thr Asn Gly Thr Leu Thr Ala Asn Asn Arg 
            100                 105                 110         


Ala Tyr Asp Asp Ile Phe Val Asp Gln Gly Val Pro Arg Phe Pro Gly 
        115                 120                 125             


Trp Phe His Asp Val Asp Lys Ala Tyr Tyr Ala Gly Ser Asn Gly Gln 
    130                 135                 140                 


Ser Glu Tyr Leu Phe Lys Glu Trp Asn Tyr Tyr Val Ala Asn Gly Ser 
145                 150                 155                 160 


Pro Leu Tyr Asn Gln Tyr Pro Asn His Thr Phe Lys Gln Ile Lys Thr 
                165                 170                 175     


Ile Ala Phe Asp Ala Pro Arg Ile Lys Gln Gly Asn Thr Asp Gly Ile 
            180                 185                 190         


Asn Leu Asn Leu Lys Gln Arg Asn Pro Asp Tyr Val Ile Ile Asn Gly 
        195                 200                 205             


Leu Thr Gly Asp Gly Ser Thr Leu Lys Asp Leu Glu Leu Pro Glu Ser 
    210                 215                 220                 


Val Lys Lys Val Ser Ile Tyr Gly Asp Tyr His Ser Ile Asn Val Ala 
225                 230                 235                 240 


Lys Gln Ile Phe Lys Asn Val Leu Glu Leu Glu Phe Tyr Ser Thr Asn 
                245                 250                 255     


Gln Asp Asn Asn Phe Gly Phe Asn Pro Leu Val Leu Gly Asp His Thr 
            260                 265                 270         


Asn Ile Ile Tyr Asp Leu Phe Val Ser Lys Pro Phe Asn Tyr Ile Asp 
        275                 280                 285             


Leu Thr Ser Leu Glu Leu Lys Asp Asn Gln Asp Asn Ile Asp Ala Ser 
    290                 295                 300                 


Lys Leu Lys Arg Ala Val Ser Asp Ile Tyr Ile Arg Arg Arg Phe Glu 
305                 310                 315                 320 


Arg Gln Met Gln Gly Tyr Trp Ala Gly Gly Tyr Ile Asp Arg Tyr Leu 
                325                 330                 335     


Val Lys Asn Thr Asn Glu Lys Asn Val Asn Lys Asp Asn Asp Thr Val 
            340                 345                 350         


Tyr Ala Ala Leu Lys Asp Ile Asn Leu His Leu Glu Glu Thr Tyr Thr 
        355                 360                 365             


His Gly Gly Asn Thr Met Tyr Arg Val Asn Glu Asn Tyr Tyr Pro Gly 
    370                 375                 380                 


Ala Ser Ala Tyr Glu Ala Glu Arg Ala Thr Arg Asp Ser Glu Phe Gln 
385                 390                 395                 400 


Lys Glu Ile Val Gln Arg 
                405     


