                         SEQUENCE LISTING

<110>  R.P. Scherer Technologies, LLC
       Rabuka, David
       Drake, Penelope M.
       Kim, Yun C.
       Barfield, Robyn M.
       Bauzon, Maxine
 
<120>  ANTIBODY SPECIFIC FOR GPC3 AND METHODS OF USE THEREOF

<130>  RDWD-024WO

<150>  US 62/881,547
<151>  2019-08-01

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Gly Thr Val Arg Thr Ala Cys Leu Val Val Ala Met Leu Leu 
1               5                   10                  15      


Ser Leu Asp Phe Pro Gly Gln Ala Gln Pro Pro Pro Pro Pro Pro Asp 
            20                  25                  30          


Ala Thr Cys His Gln Val Arg Ser Phe Phe Gln Arg Leu Gln Pro Gly 
        35                  40                  45              


Leu Lys Trp Val Pro Glu Thr Pro Val Pro Gly Ser Asp Leu Gln Val 
    50                  55                  60                  


Cys Leu Pro Lys Gly Pro Thr Cys Cys Ser Arg Lys Met Glu Glu Lys 
65                  70                  75                  80  


Tyr Gln Leu Thr Ala Arg Leu Asn Met Glu Gln Leu Leu Gln Ser Ala 
                85                  90                  95      


Ser Met Glu Leu Lys Phe Leu Ile Ile Gln Asn Ala Ala Val Phe Gln 
            100                 105                 110         


Glu Ala Phe Glu Ile Val Val Arg His Ala Lys Asn Tyr Thr Asn Ala 
        115                 120                 125             


Met Phe Lys Asn Asn Tyr Pro Ser Leu Thr Pro Gln Ala Phe Glu Phe 
    130                 135                 140                 


Val Gly Glu Phe Phe Thr Asp Val Ser Leu Tyr Ile Leu Gly Ser Asp 
145                 150                 155                 160 


Ile Asn Val Asp Asp Met Val Asn Glu Leu Phe Asp Ser Leu Phe Pro 
                165                 170                 175     


Val Ile Tyr Thr Gln Leu Met Asn Pro Gly Leu Pro Asp Ser Ala Leu 
            180                 185                 190         


Asp Ile Asn Glu Cys Leu Arg Gly Ala Arg Arg Asp Leu Lys Val Phe 
        195                 200                 205             


Gly Asn Phe Pro Lys Leu Ile Met Thr Gln Val Ser Lys Ser Leu Gln 
    210                 215                 220                 


Val Thr Arg Ile Phe Leu Gln Ala Leu Asn Leu Gly Ile Glu Val Ile 
225                 230                 235                 240 


Asn Thr Thr Asp His Leu Lys Phe Ser Lys Asp Cys Gly Arg Met Leu 
                245                 250                 255     


Thr Arg Met Trp Tyr Cys Ser Tyr Cys Gln Gly Leu Met Met Val Lys 
            260                 265                 270         


Pro Cys Gly Gly Tyr Cys Asn Val Val Met Gln Gly Cys Met Ala Gly 
        275                 280                 285             


Val Val Glu Ile Asp Lys Tyr Trp Arg Glu Tyr Ile Leu Ser Leu Glu 
    290                 295                 300                 


Glu Leu Val Asn Gly Met Tyr Arg Ile Tyr Asp Met Glu Asn Val Leu 
305                 310                 315                 320 


Leu Gly Leu Phe Ser Thr Ile His Asp Ser Ile Gln Tyr Val Gln Lys 
                325                 330                 335     


Asn Ala Gly Lys Leu Thr Thr Thr Ile Gly Lys Leu Cys Ala His Ser 
            340                 345                 350         


Gln Gln Arg Gln Tyr Arg Ser Ala Tyr Tyr Pro Glu Asp Leu Phe Ile 
        355                 360                 365             


Asp Lys Lys Val Leu Lys Val Ala His Val Glu His Glu Glu Thr Leu 
    370                 375                 380                 


Ser Ser Arg Arg Arg Glu Leu Ile Gln Lys Leu Lys Ser Phe Ile Ser 
385                 390                 395                 400 


Phe Tyr Ser Ala Leu Pro Gly Tyr Ile Cys Ser His Ser Pro Val Ala 
                405                 410                 415     


Glu Asn Asp Thr Leu Cys Trp Asn Gly Gln Glu Leu Val Glu Arg Tyr 
            420                 425                 430         


Ser Gln Lys Ala Ala Arg Asn Gly Met Lys Asn Gln Phe Asn Leu His 
        435                 440                 445             


Glu Leu Lys Met Lys Gly Pro Glu Pro Val Val Ser Gln Ile Ile Asp 
    450                 455                 460                 


Lys Leu Lys His Ile Asn Gln Leu Leu Arg Thr Met Ser Met Pro Lys 
465                 470                 475                 480 


Gly Arg Val Leu Asp Lys Asn Leu Asp Glu Glu Gly Phe Glu Ser Gly 
                485                 490                 495     


Asp Cys Gly Asp Asp Glu Asp Glu Cys Ile Gly Gly Ser Gly Asp Gly 
            500                 505                 510         


Met Ile Lys Val Lys Asn Gln Leu Arg Phe Leu Ala Glu Leu Ala Tyr 
        515                 520                 525             


Asp Leu Asp Val Asp Asp Ala Pro Gly Asn Ser Gln Gln Ala Thr Pro 
    530                 535                 540                 


Lys Asp Asn Glu Ile Ser Thr Phe His Asn Leu Gly Asn Val His Ser 
545                 550                 555                 560 


Pro Leu Lys Leu Leu Thr Ser Met Ala Ile Ser Val Val Cys Phe Phe 
                565                 570                 575     


Phe Leu Val His 
            580 


<210>  2
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  2

Gly Tyr Thr Phe Thr Ser Tyr Phe Leu His 
1               5                   10  


<210>  3
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  3

Gly Tyr Thr Phe Thr Ser Tyr Tyr Met His 
1               5                   10  


<210>  4
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  4

Ile Ile Asp Pro Pro Thr Gly Arg Thr Thr Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  5

Gly Asn Tyr Gly Gly Arg Tyr Phe Asp Tyr 
1               5                   10  


<210>  6
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  6

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  7

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  8

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  9
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Phe Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Pro Thr Gly Arg Thr Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Tyr Gly Gly Arg Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  10
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  11
<211>  449
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  11

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Phe Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Pro Thr Gly Arg Thr Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Tyr Gly Gly Arg Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  12
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  13
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Pro Thr Gly Arg Thr Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Tyr Gly Gly Arg Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  14
<211>  449
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asp Pro Pro Thr Gly Arg Thr Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Tyr Gly Gly Arg Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  15
<211>  1347
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  15
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactttt tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata attgatccgc ctactggtcg gacaacctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagggaac      300

tacgggggca gatactttga ctactggggc cagggaaccc tggtcaccgt ctcgagcgcc      360

tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaagagatg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtctcc gggtaaa                                         1347


<210>  16
<211>  1347
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  16
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctactaca tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata attgatccgc ctactggtcg gacaacctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagggaac      300

tacgggggca gatactttga ctactggggc cagggaaccc tggtcaccgt ctcgagcgcc      360

tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaagagatg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtctcc gggtaaa                                         1347


<210>  17
<211>  642
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  17
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta ccccgctcac tttcggcgga      300

gggaccaagg tggaaatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  18
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  18

His His His His His 
1               5   


<210>  19
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  19

His His His His His His 
1               5       


<210>  20
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  20

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  21
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  21

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  22

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  23
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  23

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  24
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  24

Arg Tyr Ile Arg Ser 
1               5   


<210>  25
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  25

Phe His His Thr 
1               


<210>  26
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  26

Trp Glu Ala Ala Ala Arg Glu Ala Cys Cys Arg Glu Cys Cys Ala Arg 
1               5                   10                  15      


Ala 
    


<210>  27
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  The residues may be repeated n times, where n is an integer of at
       least one.

<400>  27

Gly Ser Gly Gly Ser 
1               5   


<210>  28
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  The residues may be repeated n times, where n is an integer of at
       least one.

<400>  28

Gly Gly Gly Ser 
1               


<210>  29
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  29

Gly Gly Ser Gly 
1               


<210>  30
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  30

Gly Gly Ser Gly Gly 
1               5   


<210>  31
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  31

Gly Ser Gly Ser Gly 
1               5   


<210>  32
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  32

Gly Ser Gly Gly Gly 
1               5   


<210>  33
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  33

Gly Gly Gly Ser Gly 
1               5   


<210>  34
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  34

Gly Ser Ser Ser Gly 
1               5   


<210>  35
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa may be Cys or Ser.

<400>  35

Leu Xaa Thr Pro Ser Arg 
1               5       


<210>  36
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  36

Leu Cys Thr Pro Ser Arg 
1               5       


<210>  37
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  37

Leu Ser Thr Pro Ser Arg 
1               5       


<210>  38
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is 2 formylglycine.

<400>  38

Leu Xaa Thr Pro Ser Arg 
1               5       


<210>  39
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is a 2-formylglycine residue having a covalently attached 
       moiety

<400>  39

Leu Xaa Thr Pro Ser Arg 
1               5       


<210>  40
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is present or absent and, when present, can be any amino 
       acid, though usually an aliphatic amino acid, a sulfur-containing
       amino acid, or a polar, uncharged amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is cysteine or serine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be any amino acid, though usually an aliphatic amino 
       acid, a polar, uncharged amino acid, or a sulfur containing amino
       acid (i.e., other than a aromatic amino acid or a charged amino 
       acid), e.g., S, T, A, V, G or C; e.g., S, T, A, V or G

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is proline or alanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be any amino acid, though usually an aliphatic amino 
       acid, a polar, uncharged amino acid, or a sulfur containing amino
       acid (i.e., other than a aromatic amino acid or a charged amino 
       acid), e.g., S, T, A, V, G or C; e.g., S, T, A, V or G

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is a basic amino acid (e.g., arginine (R), and may be lysine 
       (K) or histidine (H), usually lysine), or an aliphatic amino acid
       (alanine (A), glycine (G), leucine (L), valine (V), isoleucine 
       (I), or proline (P), usually A, G, L, V, or I

<400>  40

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  41
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is present or absent and, when present, is any amino acid, 
       with the proviso that when the sulfatase motif is at an 
       N-terminus of the polypeptide, X1 is present

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is 2 formylglycine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is a proline or alanine residue

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  Xaa is a basic amino acid

<400>  41

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  42
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa may be present or absent and, when present, can be any amino 
       acid, though usually an aliphatic amino acid, a sulfur-containing
       amino acid, or a polar, uncharged amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is a 2-formylglycine residue having a covalently attached 
       moiety

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be any amino acid, though usually an aliphatic amino 
       acid, a sulfur-containing amino acid, or a polar, uncharged amino
       acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be any amino acid, though usually an aliphatic amino 
       acid, a sulfur-containing amino acid, or a polar, uncharged amino
       acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is a basic amino acid (e.g., arginine (R), and may be lysine 
       (K) or histidine (H), usually lysine), or an aliphatic amino acid
       (alanine (A), glycine (G), leucine (L), valine (V), isoleucine 
       (I), or proline (P), usually A, G, L, V, or I

<400>  42

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


