                         SEQUENCE LISTING

<110>  YALE UNIVERSITY
       GLAZER, PETER
       QUIJANO, ELIAS
       SALTZMAN, W. MARK
       SUH, HEE WON
 
<120>  COMPOSITIONS AND METHODS FOR TREATING SICKLE CELL DISEASE

<130>  YU 7756 PCT

<150>  U.S.S.N. 62/881,170
<151>  2019-07-30

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  1
tctccttaaa cctgt                                                        15


<210>  2
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  2
tctccttaaa cctgtctt                                                     18


<210>  3
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  linked by a linker

<400>  3
ttnntnttct ccttaaacct gt                                                22


<210>  4
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  linked by a linker

<400>  4
ttnntnttct ccttaaacct gtctt                                             25


<210>  5
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  lysine-lysine-lysine

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  linked by three 8-amino-3,6-dioxaoctanoic acid, 6-aminohexanoic 
       acid, or 8-amino-2, 6, 10-trioxaoctanoic acid moieties

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  lysine-lysine-lysine

<400>  5
ttnntnttct ccttaaacct gtctt                                             25


<210>  6
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  lysine-lysine-lysine

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  linked by three 8-amino-3,6-dioxaoctanoic acid, 6-aminohexanoic 
       acid, or 8-amino-2, 6, 10-trioxaoctanoic acid moieties

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  lysine-lysine-lysine

<400>  6
ttnntnttct ccttaaacct gt                                                22


<210>  7
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  7
cttctccaca ggagt                                                        15


<210>  8
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  8
cttctccaca ggagtcag                                                     18


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  9
cttctccaca ggagtcaggt gc                                                22


<210>  10
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  linked by a linker

<400>  10
nntnttnctt ctccacagga gt                                                22


<210>  11
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  linked by a linker

<400>  11
nntnttnctt ctccacagga gtcag                                             25


<210>  12
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  linked by a linker

<400>  12
nntnttnctt ctccacagga gtcaggtgc                                         29


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  lysine-lysine-lysine

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  linked by three 8-amino-3,6-dioxaoctanoic acid, 6-aminohexanoic 
       acid, or 8-amino-2, 6, 10-trioxaoctanoic acid moieties

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  lysine-lysine-lysine

<400>  13
nntnttnctt ctccacagga gt                                                22


<210>  14
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  lysine-lysine-lysine

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  linked by three 8-amino-3,6-dioxaoctanoic acid, 6-aminohexanoic 
       acid, or 8-amino-2, 6, 10-trioxaoctanoic acid moieties

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  lysine-lysine-lysine

<400>  14
nntnttnctt ctccacagga gtcag                                             25


<210>  15
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  lysine-lysine-lysine

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  linked by three 8-amino-3,6-dioxaoctanoic acid, 6-aminohexanoic 
       acid, or 8-amino-2, 6, 10-trioxaoctanoic acid moieties

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  lysine-lysine-lysine

<400>  15
nntnttnctt ctccacagga gtcaggtgc                                         29


<210>  16
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  16
tcttctctgt ctccac                                                       16


<210>  17
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  17
tcttctctgt ctccacat                                                     18


<210>  18
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  linked by a linker

<400>  18
tntnttnttc ttctctgtct ccac                                              24


<210>  19
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  linked by a linker

<400>  19
tntnttnttc ttctctgtct ccacat                                            26


<210>  20
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  lysine-lysine-lysine

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  linked by three 8-amino-3,6-dioxaoctanoic acid, 6-aminohexanoic 
       acid, or 8-amino-2, 6, 10-trioxaoctanoic acid moieties

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  lysine-lysine-lysine

<400>  20
tntnttnttc ttctctgtct ccac                                              24


<210>  21
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  lysine-lysine-lysine

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n = pseudoisocytosine

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  linked by three 8-amino-3,6-dioxaoctanoic acid, 6-aminohexanoic 
       acid, or 8-amino-2, 6, 10-trioxaoctanoic acid moieties

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  lysine-lysine-lysine

<400>  21
tntnttnttc ttctctgtct ccacat                                            26


<210>  22
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  22
ttgccccaca gggcagtaac ggcagacttc tcctcaggag tcaggtgcac catggtgtct       60

gtttg                                                                   65


<210>  23
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  23
acagacacca tggtgcacct gactcctgag gagaagtctg ccgttactgc c                51


<210>  24
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  24
cttgccccac agggcagtaa cggcagattt ttcttccggc gttaaatgca ccatggtgtc       60

tgtttgaggt                                                              70


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  25

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  26

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  27
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  27

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  28
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  28

His His His His Arg Lys Lys Arg Arg Gln Arg Arg Arg Arg His His 
1               5                   10                  15      


His His His 
            


<210>  29
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  29

Met Val Lys Ser Lys Ile Gly Ser Trp Ile Leu Val Leu Phe Val Ala 
1               5                   10                  15      


Met Trp Ser Asp Val Gly Leu Cys Lys Lys Arg Pro Lys Pro 
            20                  25                  30  


<210>  30
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  30

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


