                               SEQUENCE LISTING

<110> IMMUNOME, INC.
 
<120> IL-38-SPECIFIC ANTIBODIES

<130> 172.0008-WO00

<150> 62/880,265
<151> 2019-07-30

<160> 85    

<170> PatentIn version 3.5

<210> 1
<211> 355
<212> DNA
<213> Homo sapiens

<220>
<223> Clone PR087-29B5 IL38 VH nucleic acid

<400> 1
gtgaaggtct cctgcaaggc ttctggttac agctttatca actatggcat cacctgggtg       60

cgccaggtcc ctggacaagg gcttgagtgg atgggatgga tcagcgctta caatgttaag      120

acaaagtatg caccgaagtt ccagggcaga gtcaacatga atacagacac atccacgagg      180

acagcctaca tggagctgag gagcctgaga tctgacgaca cggccgtcta ttactgtgcg      240

agagataggg attacgattt ttggagtggt tcggcttttg atatctgggg ccaagggaca      300

atggtcaccg tctcttcagc ctccaccaag ggcccatcgg tcttccccct ggcgc           355


<210> 2
<211> 118
<212> PRT
<213> Homo sapiens

<220>
<223> Clone PR087-29B5 IL38 VH amino acid

<400> 2
Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ile Asn Tyr Gly 
1               5                   10                  15      


Ile Thr Trp Val Arg Gln Val Pro Gly Gln Gly Leu Glu Trp Met Gly 
            20                  25                  30          


Trp Ile Ser Ala Tyr Asn Val Lys Thr Lys Tyr Ala Pro Lys Phe Gln 
        35                  40                  45              


Gly Arg Val Asn Met Asn Thr Asp Thr Ser Thr Arg Thr Ala Tyr Met 
    50                  55                  60                  


Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
65                  70                  75                  80  


Arg Asp Arg Asp Tyr Asp Phe Trp Ser Gly Ser Ala Phe Asp Ile Trp 
                85                  90                  95      


Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
            100                 105                 110         


Ser Val Phe Pro Leu Ala 
        115             


<210> 3
<211> 308
<212> DNA
<213> Homo sapiens

<220>
<223> Clone PR087-29B5 IL38 VL nucleic acid		

<400> 3
aagagtcacc ctctcctgca gggccagtca gagtattagc accaactact tagcctggta       60

ccagcagaaa cctggccagg ctcccagtct actcatctat ggtgcatcca gcagggccac      120

tggcatccca gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag      180

cagactggag cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacctcc      240

gaggactttt ggccagggga ccaagctgga gatcagacga actgtggctg caccatctgt      300

cttcatct                                                               308


<210> 4
<211> 102
<212> PRT
<213> Homo sapiens

<220>
<223> Clone PR087-29B5 IL38 VL amino acid

<400> 4
Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Thr Asn Tyr 
1               5                   10                  15      


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ser Leu Leu Ile 
            20                  25                  30          


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
        35                  40                  45              


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
    50                  55                  60                  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Pro 
65                  70                  75                  80  


Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Arg Arg Thr Val Ala 
                85                  90                  95      


Ala Pro Ser Val Phe Ile 
            100         


<210> 5
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<223> IMM20130 IL38 VH nucleic acid

<400> 5
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcgcctc tgtgaaggtg       60

tcctgcaagg ccagcggcta cagcttcatc aactacggca tcacctgggt ccgacaggtg      120

ccaggacaag gcttggaatg gatgggctgg atcagcgcct acaacgtcaa gaccaaatac      180

gcccctaagt tccagggccg cgtgaacatg aacaccgaca ccagcaccag aaccgcctac      240

atggaactgc ggagcctgag atccgatgac accgccgtgt actactgcgc cagagacaga      300

gactacgact tttggagcgg cagcgccttc gatatctggg gccagggaac aatggtcacc      360

gtgtctagt                                                              369


<210> 6
<211> 369
<212> DNA
<213> Homo sapiens

<220>
<223> IMM20130 IL38 VH codon optimized expression fragment 
      nucleic acid

<400> 6
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcgcctc tgtgaaggtg       60

tcctgcaagg ccagcggcta cagcttcatc aactacggca tcacctgggt ccgacaggtg      120

ccaggacaag gcttggaatg gatgggctgg atcagcgcct acaacgtcaa gaccaaatac      180

gcccctaagt tccagggccg cgtgaacatg aacaccgaca ccagcaccag aaccgcctac      240

atggaactgc ggagcctgag atccgatgac accgccgtgt actactgcgc cagagacaga      300

gactacgact tttggagcgg cagcgccttc gatatctggg gccagggaac aatggtcacc      360

gtgtctagt                                                              369


<210> 7
<211> 123
<212> PRT
<213> Homo sapiens

<220>
<223> IMM20130 IL38 VH amino acid

<400> 7
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ile Asn Tyr 
            20                  25                  30          


Gly Ile Thr Trp Val Arg Gln Val Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Val Lys Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Asn Met Asn Thr Asp Thr Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Asp Tyr Asp Phe Trp Ser Gly Ser Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210> 8
<211> 324
<212> DNA
<213> Homo sapiens

<220>
<223> IMM20130 IL38 VL nucleic acid 

<400> 8
gagatcgtgc tgacacagag ccctggcaca ctgtcactgt ctccaggcga gagagtgacc       60

ctgagctgta gagccagcca gagcatcagc accaactacc tggcctggta tcagcagaag      120

cctggacagg ctcctagcct gctgatctac ggcgcctctt ctagagccac aggcatcccc      180

gatagattca gcggctctgg cagcggcacc gatttcaccc tgacaatcag cagactggaa      240

cccgaggact tcgccgtgta ctactgtcag cagtacggca gcagccctcc tagaacattt      300

ggccagggca ccaagctgga aatc                                             324


<210> 9
<211> 327
<212> DNA
<213> Homo sapiens

<220>
<223> IMM20130 IL38 VL codon optimized expression fragment
      nucleic acid 

<400> 9
gagatcgtgc tgacacagag ccctggcaca ctgtcactgt ctccaggcga gagagtgacc       60

ctgagctgta gagccagcca gagcatcagc accaactacc tggcctggta tcagcagaag      120

cctggacagg ctcctagcct gctgatctac ggcgcctctt ctagagccac aggcatcccc      180

gatagattca gcggctctgg cagcggcacc gatttcaccc tgacaatcag cagactggaa      240

cccgaggact tcgccgtgta ctactgtcag cagtacggca gcagccctcc tagaacattt      300

ggccagggca ccaagctgga aatcaag                                          327


<210> 10
<211> 109
<212> PRT
<213> Homo sapiens

<220>
<223> IMM20130 IL38 VL amino acid 

<400> 10
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Thr Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ser Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 


<210> 11
<211> 1365
<212> DNA
<213> Homo sapiens

<220>
<223> IMM20130 IL38 HC nucleic acid 

<400> 11
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcgcctc tgtgaaggtg       60

tcctgcaagg ccagcggcta cagcttcatc aactacggca tcacctgggt ccgacaggtg      120

ccaggacaag gcttggaatg gatgggctgg atcagcgcct acaacgtcaa gaccaaatac      180

gcccctaagt tccagggccg cgtgaacatg aacaccgaca ccagcaccag aaccgcctac      240

atggaactgc ggagcctgag atccgatgac accgccgtgt actactgcgc cagagacaga      300

gactacgact tttggagcgg cagcgccttc gatatctggg gccagggaac aatggtcacc      360

gtgtctagtg ccagcaccaa gggcccttcc gtgtttccac tggccccctc ctctaaatcc      420

acatctggcg gcaccgccgc cctgggctgt ctggtgaagg actacttccc agagcctgtg      480

acagtgtcct ggaactctgg cgccctgaca tccggcgtgc acacatttcc agccgtgctg      540

cagagctccg gcctgtacag cctgtctagc gtggtgacag tgccctcctc tagcctgggc      600

acacagacct atatctgcaa cgtgaatcac aagccaagca ataccaaggt ggacaagaag      660

gtggagccca agtcctgtga taagacacac acctgccccc cttgtcctgc tcccgagctg      720

ctgggcggcc ctagcgtgtt cctgtttcca cccaagccta aggacaccct gatgatctcc      780

cggacacccg aggtgacctg cgtggtggtg gacgtgtctc acgaggatcc tgaggtgaag      840

ttcaactggt atgtggatgg cgtggaggtg cacaatgcca agaccaagcc cagagaggag      900

cagtacaact ctacatatag ggtggtgagc gtgctgaccg tgctgcacca ggactggctg      960

aacggcaagg agtataagtg caaggtgtcc aataaggccc tgcccgcccc catcgagaag     1020

acaatcagca aggccaaggg ccagcctcgg gagccacagg tgtacaccct gcctccatcc     1080

agagacgagc tgacaaagaa ccaggtgtct ctgacatgtc tggtgaaggg cttctatcct     1140

agcgatatcg ccgtggagtg ggagtccaat ggccagccag agaacaatta caagaccaca     1200

ccccctgtgc tggactccga tggctccttc tttctgtatt ccaagctgac cgtggataag     1260

tctcggtggc agcagggcaa cgtgttcagc tgttccgtga tgcacgaagc cctgcataat     1320

cactatactc agaaatccct gtccctgtca cctggaaagt gataa                     1365


<210> 12
<211> 453
<212> PRT
<213> Homo sapiens

<220>
<223> IMM20130 IL38 HC amino acid 

<400> 12
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ile Asn Tyr 
            20                  25                  30          


Gly Ile Thr Trp Val Arg Gln Val Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Ser Ala Tyr Asn Val Lys Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Asn Met Asn Thr Asp Thr Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Asp Tyr Asp Phe Trp Ser Gly Ser Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210> 13
<211> 654
<212> DNA
<213> Homo sapiens

<220>
<223> IMM20130 IL38 LC nucleic acid 

<400> 13
gagatcgtgc tgacacagag ccctggcaca ctgtcactgt ctccaggcga gagagtgacc       60

ctgagctgta gagccagcca gagcatcagc accaactacc tggcctggta tcagcagaag      120

cctggacagg ctcctagcct gctgatctac ggcgcctctt ctagagccac aggcatcccc      180

gatagattca gcggctctgg cagcggcacc gatttcaccc tgacaatcag cagactggaa      240

cccgaggact tcgccgtgta ctactgtcag cagtacggca gcagccctcc tagaacattt      300

ggccagggca ccaagctgga aatcaagagg acagtggccg ccccaagcgt gttcatcttt      360

cccccttccg acgagcagct gaagtctggc accgccagcg tggtgtgcct gctgaacaac      420

ttctaccctc gggaggccaa ggtccagtgg aaggtggata acgccctgca gtctggcaat      480

agccaggagt ccgtgaccga gcaggactct aaggatagca catattccct gtctagcacc      540

ctgacactga gcaaggccga ttacgagaag cacaaggtgt atgcctgtga agtcacccat      600

caggggctgt catcacccgt cactaagtca ttcaatcgcg gagaatgctg ataa            654


<210> 14
<211> 216
<212> PRT
<213> Homo sapiens

<220>
<223> IMM20130 IL38 LC amino acid 

<400> 14
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Thr Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ser Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210> 15
<211> 13
<212> PRT
<213> Homo sapiens

<220>
<223> IMM20130 IL38 VH-CDR1 amino acid 

<400> 15
Lys Ala Ser Gly Tyr Ser Phe Ile Asn Tyr Gly Ile Thr 
1               5                   10              


<210> 16
<211> 10
<212> PRT
<213> Homo sapiens

<220>
<223> IMM20130 IL38 VH-CDR2 amino acid 

<400> 16
Trp Ile Ser Ala Tyr Asn Val Lys Thr Lys 
1               5                   10  


<210> 17
<211> 16
<212> PRT
<213> Homo sapiens

<220>
<223> IMM20130 IL38 VH-CDR3 amino acid 

<400> 17
Ala Arg Asp Arg Asp Tyr Asp Phe Trp Ser Gly Ser Ala Phe Asp Ile 
1               5                   10                  15      


<210> 18
<211> 12
<212> PRT
<213> Homo sapiens

<220>
<223> IMM20130 IL38 VL-CDR1 amino acid 

<400> 18
Arg Ala Ser Gln Ser Ile Ser Thr Asn Tyr Leu Ala 
1               5                   10          


<210> 19
<211> 8
<212> PRT
<213> Homo sapiens

<220>
<223> IMM20130 IL38 VL-CDR2 amino acid 

<400> 19
Tyr Gly Ala Ser Ser Arg Ala Thr 
1               5               


<210> 20
<211> 10
<212> PRT
<213> Homo sapiens

<220>
<223> IMM20130 IL38 VL-CDR3 amino acid 

<400> 20
Gln Gln Tyr Gly Ser Ser Pro Pro Arg Thr 
1               5                   10  


<210> 21
<211> 352
<212> DNA
<213> Mus sp.

<220> 
<223> Clone M3 IL38-C VH nucleic acid 

<400> 21
gaggtccagc tgcaacagtc tggacctgag ctggtgaagc ctggggcttc agtgaaaata       60

ccctgcaagg cttctggata cacattcact gactacaata tggactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggagat attaatccta acaatggtgg tactatctac      180

aaccagaagt tcaagggcaa ggccacattg actgtagaca agtcttccag cacagcctac      240

atggagctcc gcagcctgac atctgaggac actgcagtct attactgttc aagaccctat      300

tatggttact ttgcttactg gggccaaggg actctggtca ctgtctctgc ag              352


<210> 22
<211> 117
<212> PRT
<213> Mus sp.

<220>
<223> Clone M3 IL38-C VH amino acid 

<400> 22
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Pro Tyr Tyr Gly Tyr Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210> 23
<211> 13
<212> PRT
<213> Mus sp.

<220>
<223> Clone M3 IL38-C VH CDR1 amino acid 

<400> 23
Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Asn Met Asp 
1               5                   10              


<210> 24
<211> 10
<212> PRT
<213> Mus sp.

<220>
<223> Clone M3 IL38-C VH CDR2 amino acid 

<400> 24
Asp Ile Asn Pro Asn Asn Gly Gly Thr Ile 
1               5                   10  


<210> 25
<211> 10
<212> PRT
<213> Mus sp.

<220>
<223> Clone M3 IL38-C VH CDR3 amino acid 

<400> 25
Ser Arg Pro Tyr Tyr Gly Tyr Phe Ala Tyr 
1               5                   10  


<210> 26
<211> 337
<212> DNA
<213> Mus sp.

<220>
<223> Clone M3 IL38-C VH Alternate nucleic acid 

<400> 26
gaggtccagc tgcaacagtc tggacctgag ttggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggcta cacattcact gactactaca tacactgggt gaagcagagc      120

catggaaagg gccttgagtg gattggatat atttttccta ataatggtgg taatggctac      180

agccagaagt tcaagggcaa ggccacaatg actgtagaca agtcctccag cacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgcagtct attattgtgc aagatttgtt      300

tactggggcc aagggacgct ggtcactgtc tctgcag                               337


<210> 27
<211> 112
<212> PRT
<213> Mus sp.

<220>
<223> Clone M3 IL38-C VH Alternate amino acid 

<400> 27
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Ser His Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Phe Pro Asn Asn Gly Gly Asn Gly Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
            100                 105                 110         


<210> 28
<211> 13
<212> PRT
<213> Mus sp.

<220>
<223> Clone M3 IL38-C VH Alternate CDR1 amino acid 

<400> 28
Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Ile His 
1               5                   10              


<210> 29
<211> 10
<212> PRT
<213> Mus sp.

<220>
<223> Clone M3 IL38-C VH Alternate CDR2 amino acid 

<400> 29
Tyr Ile Phe Pro Asn Asn Gly Gly Asn Gly 
1               5                   10  


<210> 30
<211> 11
<212> PRT
<213> Mus sp.

<220>
<223> Clone M3 IL38-C VH Alternate CDR3 amino acid 

<400> 30
Ala Arg Gly Gly Tyr Asp Ala Gly Phe Val Tyr 
1               5                   10      


<210> 31
<211> 355
<212> DNA
<213> Mus sp.

<220>
<223> Clone M8 IL38-C VH nucleic acid 

<400> 31
gaggtccarc tgcaacagtc tggacctgag ttggtgaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggcta cacattcact gactactaca tacactgggt gaagcagagc      120

catggaaagg gccttgagtg gattggatat atttttccta ataatggtgg taatggctac      180

agccagaagt tcaagggcaa ggccacaatg actgtagaca agtcctccag cacagcctac      240

atggagctcc gcagcctgac atctgaggac tctgcagtct attattgtgc aagagggggc      300

tacgacgcgg ggtttgttta ctggggccaa gggacgctgg tcactgtctc tgcag           355


<210> 32
<211> 118
<212> PRT
<213> Mus sp.

<220>
<223> Clone M8 IL38-C VH amino acid 

<400> 32
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Ser His Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Phe Pro Asn Asn Gly Gly Asn Gly Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Ala Gly Phe Val Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210> 33
<211> 13
<212> PRT
<213> Mus sp.

<220>
<223> Clone M8 IL38-C VH CDR1 amino acid 

<400> 33
Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Ile His 
1               5                   10              


<210> 34
<211> 10
<212> PRT
<213> Mus sp.

<220>
<223> Clone M8 IL38-C VH CDR2 amino acid 

<400> 34
Tyr Ile Phe Pro Asn Asn Gly Gly Asn Gly 
1               5                   10  


<210> 35
<211> 11
<212> PRT
<213> Mus sp.

<220>
<223> Clone M8 IL38-C VH CDR3 amino acid 

<400> 35
Ala Arg Gly Gly Tyr Asp Ala Gly Phe Val Tyr 
1               5                   10      


<210> 36
<211> 370
<212> DNA
<213> Mus sp.

<220>
<223> Clone M27 IL38-C HC nucleic acid 

<400> 36
gaggtgcagc ttgttgagtc tggtggaaga ttggtacagc ctaaagggtc attgaaactc       60

tcatgtgcag cctctggatt caccttcaat acctatgcca tgtactggat ccgccaggct      120

ccaggaaagg gtttggaatg ggttgctcgc ataagaacta aaagtaataa ttttgcaaca      180

tattatgccg attcagtgaa agacagattc accatctcca gagatgattc acaaaacatg      240

ctctatctgc aaatgaacaa cctgaaaact gaggacacag ccatgtatta ctgtgtgctc      300

ggatttggat ggcccactta ctatactctg gactactggg gtcaaggaac ctcagtcacc      360

gtctcctcag                                                             370


<210> 37
<211> 123
<212> PRT
<213> Mus sp.

<220>
<223> Clone M27 IL38-C VH amino acid 

<400> 37
Glu Val Gln Leu Val Glu Ser Gly Gly Arg Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Tyr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Thr Lys Ser Asn Asn Phe Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Asn Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Leu Gly Phe Gly Trp Pro Thr Tyr Tyr Thr Leu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210> 38
<211> 13
<212> PRT
<213> Mus sp.

<220>
<223> Clone M27 IL38-C VH CDR1 amino acid 

<400> 38
Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr Ala Met Tyr 
1               5                   10              


<210> 39
<211> 12
<212> PRT
<213> Mus sp.

<220>
<223> Clone M27 IL38-C VH CDR2 amino acid 

<400> 39
Arg Ile Arg Thr Lys Ser Asn Asn Phe Ala Thr Tyr 
1               5                   10          


<210> 40
<211> 14
<212> PRT
<213> Mus sp.

<220>
<223> Clone M27 IL38-C VH CDR3 amino acid 

<400> 40
Val Leu Gly Phe Gly Trp Pro Thr Tyr Tyr Thr Leu Asp Tyr 
1               5                   10                  


<210> 41
<211> 358
<212> DNA
<213> Mus sp.

<220>
<223> Clone M2 IL38-N VH nucleic acid 

<400> 41
caggtccaac tgcagcagcc tggkgctgag cttgtgaagc ctggggcctc agtgaagctg       60

tcctgcaagg cttctggcta cactttcacc agctactgga taaactgggt gaagcagagg      120

cctggacaag gccttgagtg gattggaaat atttatcctg ttagtagtaa tactaagtac      180

aatgagaagt tcaagagtaa ggccacactg actgtagaca catcctccag cacagcctac      240

atgcagctca gcagcctgac atctgacgac tctgcggtct attattgtgc aagagggggg      300

tactacggtt atgctatgga ctactggggt caaggaacct cagtcaccgt ctcctcag        358


<210> 42
<211> 119
<212> PRT
<213> Mus sp.

<220>
<223> Clone M2 IL38-N VH amino acid 

<400> 42
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Val Ser Ser Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Tyr Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210> 43
<211> 13
<212> PRT
<213> Mus sp.

<220>
<223> Clone M2 IL38-N VH CDR1 amino acid 

<400> 43
Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Ile Asn 
1               5                   10              


<210> 44
<211> 10
<212> PRT
<213> Mus sp.

<220>
<223> Clone M2 IL38-N VH CDR2 amino acid 

<400> 44
Asn Ile Tyr Pro Val Ser Ser Asn Thr Lys 
1               5                   10  


<210> 45
<211> 12
<212> PRT
<213> Mus sp.

<220>
<223> Clone M2 IL38-N VH CDR3 amino acid 

<400> 45
Ala Arg Gly Gly Tyr Tyr Gly Tyr Ala Met Asp Tyr 
1               5                   10          


<210> 46
<211> 340
<212> DNA
<213> Mus sp.

<220>
<223> Clone M8 IL38-N VH nucleic acid 

<400> 46
gaggtccagc tgcagcagtc tggacctgag ctggtgaagc ctggggcttc agtgaagata       60

tcctgcaagg cttctggtta ctcattcact ggctactaca tgcactgggt gaagcaaagt      120

cctgaaaaga gccttgagtg gattggagtg attaatccta acactggtgg tattacctac      180

aaccagaagt tcaaggccaa ggccacattg aatgtagaca aatcctccag cacagcctac      240

atgcagctca agagcctgac atctgaggac tctgcagtct attactgtgc aagatcgatg      300

ggagtttggg gccaagggac tctggtcact gtctctgcag                            340


<210> 47
<211> 113
<212> PRT
<213> Mus sp.

<220>
<223> Clone M8 IL38-N VH amino acid 

<400> 47
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser Pro Glu Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Asn Thr Gly Gly Ile Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ala Lys Ala Thr Leu Asn Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Met Gly Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ala 
    


<210> 48
<211> 13
<212> PRT
<213> Mus sp.

<220>
<223> Clone M8 IL38-N VH CDR1 amino acid 

<400> 48
Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Tyr Met His 
1               5                   10              


<210> 49
<211> 10
<212> PRT
<213> Mus sp.

<220>
<223> Clone M8 IL38-N VH CDR2 amino acid 

<400> 49
Val Ile Asn Pro Asn Thr Gly Gly Ile Thr 
1               5                   10  


<210> 50
<211> 6
<212> PRT
<213> Mus sp.

<220>
<223> Clone M8 IL38-N VH CDR3 amino acid 

<400> 50
Ala Arg Ser Met Gly Val 
1               5       


<210> 51
<211> 349
<212> DNA
<213> Mus sp.

<220>
<223> Clone M12 IL38-N VH nucleic acid 

<400> 51
caggttcaac tgcagcagtc tggacctgag ctggtgaagc ctggggcctc agtgaagatt       60

tcctgcaaag cttctggcta cgcattcagt agctactgga tgaactgggt gaagcagagg      120

cctggaaagg gtcttgagtg gattggacgg atttatcctg gagatggaaa tactaagtac      180

aatgggatgt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcaactca gcagcctgac atctgaggac tctgcggtct tcttctgtgc aagaggggca      300

cgtggggagg actactgggg tcaaggaacc tcagtcaccg tctcctcag                  349


<210> 52
<211> 116
<212> PRT
<213> Mus sp.

<220>
<223> Clone M12 IL38-N VH amino acid 

<400> 52
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Asn Thr Lys Tyr Asn Gly Met Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Phe Phe Cys 
                85                  90                  95      


Ala Arg Gly Ala Arg Gly Glu Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 53
<211> 13
<212> PRT
<213> Mus sp.

<220>
<223> Clone M12 IL38-N VH CDR1 amino acid 

<400> 53
Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr Trp Met Asn 
1               5                   10              


<210> 54
<211> 10
<212> PRT
<213> Mus sp.

<220>
<223> Clone M12 IL38-N VH CDR2 amino acid 

<400> 54
Arg Ile Tyr Pro Gly Asp Gly Asn Thr Lys 
1               5                   10  


<210> 55
<211> 9
<212> PRT
<213> Mus sp.

<220>
<223> Clone M12 IL38-N VH CDR3 amino acid 

<400> 55
Ala Arg Gly Ala Arg Gly Glu Asp Tyr 
1               5                   


<210> 56
<211> 337
<212> DNA
<213> Mus sp.

<220>
<223> Clone M3 IL38-C VL nucleic acid 

<400> 56
gatgttgtga tgacccaatc tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctctcgca gatttagtca gagccttgta cacagtcatg aaaacacctt tttacattgg      120

tacgtgcaga agccaggcca gtctccaaag ctcctgattt acagagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300

ctcacgttcg gtgctgggac caagctggag ctgaaac                               337


<210> 57
<211> 112
<212> PRT
<213> Mus sp.

<220>
<223> Clone M3 IL38-C VL amino acid 

<400> 57
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


His Glu Asn Thr Phe Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210> 58
<211> 16
<212> PRT
<213> Mus sp.

<220>
<223> Clone M3 IL38-C VL CDR1 amino acid 

<400> 58
Arg Ser Ser Gln Ser Leu Val His Ser His Glu Asn Thr Phe Leu His 
1               5                   10                  15      


<210> 59
<211> 8
<212> PRT
<213> Mus sp.

<220>
<223> Clone M3 IL38-C VL CDR2 amino acid 

<400> 59
Tyr Arg Val Ser Asn Arg Phe Ser 
1               5               


<210> 60
<211> 9
<212> PRT
<213> Mus sp.

<220>
<223> Clone M3 IL38-C VL CDR3 amino acid 

<400> 60
Ser Gln Ser Thr His Val Pro Leu Thr 
1               5                   


<210> 61
<211> 337
<212> DNA
<213> Mus sp.

<220>
<223> Clone M8 IL38-C VL nucleic acid 

<400> 61
gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgttc aacagtggag cccgaaagaa cttcttggct      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttattatctg      300

atcacgttcg gtgctgggac caagctggag ctgaaac                               337


<210> 62
<211> 112
<212> PRT
<213> Mus sp.

<220>
<223> Clone M8 IL38-C VL amino acid 

<400> 62
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Gly Ala Arg Lys Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Tyr Leu Ile Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210> 63
<211> 17
<212> PRT
<213> Mus sp.

<220>
<223> Clone M8 IL38-C VL CDR1 amino acid 

<400> 63
Lys Ser Ser Gln Ser Leu Phe Asn Ser Gly Ala Arg Lys Asn Phe Leu 
1               5                   10                  15      


Ala 
    


<210> 64
<211> 8
<212> PRT
<213> Mus sp.

<220>
<223> Clone M8 IL38-C VL CDR2 amino acid 

<400> 64
Tyr Trp Ala Ser Thr Arg Glu Ser 
1               5               


<210> 65
<211> 8
<212> PRT
<213> Mus sp.

<220>
<223> Clone M8 IL38-C VL CDR3 amino acid 

<400> 65
Lys Gln Ser Tyr Tyr Leu Ile Thr 
1               5               


<210> 66
<211> 325
<212> DNA
<213> Mus sp.

<220>
<223> Clone M27 IL38-C VL nucleic acid 

<400> 66
caaattgttc tcacccagtc tccagcaatc atgtctgcct ctccagggga aaaggtcacc       60

atgccctgca gtgccatgtc aagtgtcagt tccaggtact tgcactggaa ccagcagaag      120

tcaggagcct cccccaaact ctggatctat ggcgcatcca acctggcttc tggagtccct      180

gctcggttca gtggcagtgg gtctgggacc tcctactctc tcacaatcat cagcgtggag      240

gatgaagatg ctgccaccta ttactgccag cagtatcata gtggagcgct cacgttcgga      300

ggggggacca agctggagat gaaac                                            325


<210> 67
<211> 108
<212> PRT
<213> Mus sp.

<220>
<223> Clone M27 IL38-C VL amino acid 

<400> 67
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Pro Cys Ser Ala Met Ser Ser Val Ser Ser Arg 
            20                  25                  30          


Tyr Leu His Trp Asn Gln Gln Lys Ser Gly Ala Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ile Ser Val Glu 
65                  70                  75                  80  


Asp Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Gly Ala 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys 
            100                 105             


<210> 68
<211> 12
<212> PRT
<213> Mus sp.

<220>
<223> Clone M27 IL38-C VL CDR1 amino acid 

<400> 68
Ser Ala Met Ser Ser Val Ser Ser Arg Tyr Leu His 
1               5                   10          


<210> 69
<211> 8
<212> PRT
<213> Mus sp.

<220>
<223> Clone M27 IL38-C VL CDR2 amino acid 

<400> 69
Tyr Gly Ala Ser Asn Leu Ala Ser 
1               5               


<210> 70
<211> 9
<212> PRT
<213> Mus sp.

<220>
<223> Clone M27 IL38-C VL CDR3 amino acid 

<400> 70
Gln Gln Tyr His Ser Gly Ala Leu Thr 
1               5                   


<210> 71
<211> 322
<212> DNA
<213> Mus sp.

<220>
<223> Clone M2 IL38-N VL nucleic acid 

<400> 71
gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc       60

ctcacatgtc gaccaagtgg gaatgttcac aattatttag catggtatca gcagaaacag      120

ggaaaatctc ctcagctcct ggtctataat gcaaaaacct tagcagatgg tgtgccatca      180

aggttcagtg gcagtggatc aggaacacaa tattctctca agatcaacag cctgcagcct      240

gaagattttg ggagttatta ctgtcaacat ttttggagta ctccattcac gttcggctcg      300

gggacaaagt tggaaataaa ac                                               322


<210> 72
<211> 107
<212> PRT
<213> Mus sp.

<220>
<223> Clone M2 IL38-N VL amino acid 

<400> 72
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Leu Thr Cys Arg Pro Ser Gly Asn Val His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 73
<211> 11
<212> PRT
<213> Mus sp.

<220> 
<223> Clone M2 IL38-N VL CDR1 amino acid 

<400> 73
Arg Pro Ser Gly Asn Val His Asn Tyr Leu Ala 
1               5                   10      


<210> 74
<211> 8
<212> PRT
<213> Mus sp.

<220>
<223> Clone M2 IL38-N VL CDR2 amino acid 

<400> 74
Tyr Asn Ala Lys Thr Leu Ala Asp 
1               5               


<210> 75
<211> 9
<212> PRT
<213> Mus sp.

<220>
<223> Clone M2 IL38-N VL CDR3 amino acid 

<400> 75
Gln His Phe Trp Ser Thr Pro Phe Thr 
1               5                   


<210> 76
<211> 337
<212> DNA
<213> Mus sp.

<220>
<223> Clone M8 IL38-N VL nucleic acid 

<400> 76
gatattgtga tgactcaggc tgcaccctct gtatctgtca ctcctggaga gtcagtatcc       60

atctcctcca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg      120

ttcctgcaga ggccaggcca gtctcctcag ctcctgatat atcggatgtc caaccttgcc      180

tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctgctttcac actgagaatc      240

agtagagtgg aggctgagga tgtgggtgtt tattactgta tgcaatatct agaatatcct      300

ttcacgttcg gctcggggac aaagctggaa ataaaac                               337


<210> 77
<211> 112
<212> PRT
<213> Mus sp.

<220>
<223> Clone M8 IL38-N VL amino acid 

<400> 77
Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Tyr 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 78
<211> 16
<212> PRT
<213> Mus sp.

<220>
<223> Clone M8 IL38-N VL CDR1 amino acid 

<400> 78
Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210> 79
<211> 8
<212> PRT
<213> Mus sp.

<220>
<223> Clone M8 IL38-N VL CDR2 amino acid 

<400> 79
Tyr Arg Met Ser Asn Leu Ala Ser 
1               5               


<210> 80
<211> 9
<212> PRT
<213> Mus sp.

<220>
<223> Clone M8 IL38-N VL CDR3 amino acid 

<400> 80
Met Gln Tyr Leu Glu Tyr Pro Phe Thr 
1               5                   


<210> 81
<211> 325
<212> DNA
<213> Mus sp.

<220>
<223> Clone M12 IL38-N VL nucleic acid 

<400> 81
gaaaatgtgc tcacccagtc tccagcaatc atgtctgcat ctccagggga aaaggtcacc       60

atgacctgca gggccagctc aagtgtaagt tccagttact tgcactggta ccagcagaag      120

tcaggtgcct cccccaaact ctggatttat agcacatcca acttggcttc tggagtccct      180

gctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag cagtgtggag      240

gctgaagatg ctgccactta ttactgccag cagtacggtg attttccact cacgttcgga      300

ggggggacca agctggaaat aaaac                                            325


<210> 82
<211> 108
<212> PRT
<213> Mus sp.

<220>
<223> Clone M12 IL38-N VL amino acid 

<400> 82
Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Asp Phe Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210> 83
<211> 12
<212> PRT
<213> Mus sp.

<220>
<223> Clone M12 IL38-N VL CDR1 amino acid 

<400> 83
Arg Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210> 84
<211> 8
<212> PRT
<213> Mus sp.

<220>
<223> Clone M12 IL38-N VL CDR2 amino acid 

<400> 84
Tyr Ser Thr Ser Asn Leu Ala Ser 
1               5               


<210> 85
<211> 9
<212> PRT
<213> Mus sp.

<220>
<223> Clone M12 IL38-N VL CDR3 amino acid 

<400> 85
Gln Gln Tyr Gly Asp Phe Pro Leu Thr 
1               5                   


