                         SEQUENCE LISTING

<110>  OKYO Pharma Limited
 
<120>  COMPOSITIONS COMPRISING CHEMERIN ANALOGS AND METHODS OF USE

<130>  OKYO-006/001WO (332777-2025)

<150>  US62/881,725
<151>  2019-08-01

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial peptide composition


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is alanine, D-alanine, or norvaline

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is alanine or glycine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 2 is phenylalanine or D-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 2 is phenylalanine or tyrosine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is norleucine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is serine or D-serine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is glutamine or alpha-aminoadipic acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is tyrosine, phenylalanine, or fluorinated 
       phenylalanine (fF)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is alanine or D-alanine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is 
       (s)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is D-alanine or D-serine

<400>  1

Xaa Xaa Xaa Xaa Xaa Pro Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10          


<210>  2
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial peptide composition


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is norleucine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is 
       (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is D-alanine

<400>  2

Ala Ala Phe Tyr Xaa Pro Ser Gln Tyr Ala Xaa Xaa 
1               5                   10          


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial peptide composition


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is D-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is norleucine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is D-serine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is alpha-aminoadipic acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is 
       (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is D-alanine

<400>  3

Ala Gly Xaa Phe Xaa Pro Xaa Xaa Phe Ala Xaa Xaa 
1               5                   10          


<210>  4
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial peptide composition


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is D-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is D-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is norleucine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is D-serine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa at position 9 is fluorinated phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is D-alanine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is 
       (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is D-alanine

<400>  4

Xaa Gly Xaa Phe Xaa Pro Xaa Gln Xaa Xaa Xaa Xaa 
1               5                   10          


<210>  5
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial peptide composition


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is norvaline

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is D-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is norleucine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is D-serine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is D-alanine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is 
       (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is D-alanine

<400>  5

Xaa Gly Xaa Phe Xaa Pro Xaa Gln Phe Xaa Xaa Xaa 
1               5                   10          


<210>  6
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial peptide composition


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is D-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is norleucine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is D-serine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is 
       (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is D-serine

<400>  6

Ala Gly Xaa Phe Xaa Pro Xaa Gln Phe Ala Xaa Xaa 
1               5                   10          


<210>  7
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial peptide composition


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is D-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is D-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is norleucine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is D-serine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is D-alanine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is 
       (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is D-alanine

<400>  7

Xaa Gly Xaa Phe Xaa Pro Xaa Gln Phe Xaa Xaa Xaa 
1               5                   10          


<210>  8
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Arg Leu Leu Ile Pro Leu Ala Leu Trp Leu Gly Ala Val Gly 
1               5                   10                  15      


Val Gly Val Ala Glu Leu Thr Glu Ala Gln Arg Arg Gly Leu Gln Val 
            20                  25                  30          


Ala Leu Glu Glu Phe His Lys His Pro Pro Val Gln Trp Ala Phe Gln 
        35                  40                  45              


Glu Thr Ser Val Glu Ser Ala Val Asp Thr Pro Phe Pro Ala Gly Ile 
    50                  55                  60                  


Phe Val Arg Leu Glu Phe Lys Leu Gln Gln Thr Ser Cys Arg Lys Arg 
65                  70                  75                  80  


Asp Trp Lys Lys Pro Glu Cys Lys Val Arg Pro Asn Gly Arg Lys Arg 
                85                  90                  95      


Lys Cys Leu Ala Cys Ile Lys Leu Gly Ser Glu Asp Lys Val Leu Gly 
            100                 105                 110         


Arg Leu Val His Cys Pro Ile Glu Thr Gln Val Leu Arg Glu Ala Glu 
        115                 120                 125             


Glu His Gln Glu Thr Gln Cys Leu Arg Val Gln Arg Ala Gly Glu Asp 
    130                 135                 140                 


Pro His Ser Phe Tyr Phe Pro Gly Gln Phe Ala Phe Ser Lys Ala Leu 
145                 150                 155                 160 


Pro Arg Ser 
            


<210>  9
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Leu Thr Glu Ala Gln Arg Arg Gly Leu Gln Val Ala Leu Glu Glu 
1               5                   10                  15      


Phe His Lys His Pro Pro Val Gln Trp Ala Phe Gln Glu Thr Ser Val 
            20                  25                  30          


Glu Ser Ala Val Asp Thr Pro Phe Pro Ala Gly Ile Phe Val Arg Leu 
        35                  40                  45              


Glu Phe Lys Leu Gln Gln Thr Ser Cys Arg Lys Arg Asp Trp Lys Lys 
    50                  55                  60                  


Pro Glu Cys Lys Val Arg Pro Asn Gly Arg Lys Arg Lys Cys Leu Ala 
65                  70                  75                  80  


Cys Ile Lys Leu Gly Ser Glu Asp Lys Val Leu Gly Arg Leu Val His 
                85                  90                  95      


Cys Pro Ile Glu Thr Gln Val Leu Arg Glu Ala Glu Glu His Gln Glu 
            100                 105                 110         


Thr Gln Cys Leu Arg Val Gln Arg Ala Gly Glu Asp Pro His Ser Phe 
        115                 120                 125             


Tyr Phe Pro Gly Gln Phe Ala Phe Ser 
    130                 135         


<210>  10
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial peptide composition


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is D-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is D-serine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is D-alanine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 10 is 
       (s)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

<400>  10

Gly Gly Xaa Phe Leu Pro Xaa Gln Phe Xaa Xaa Ser 
1               5                   10          


<210>  11
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial peptide composition


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is norleucine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is 
       (s)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is D-alanine

<400>  11

Ala Ala Tyr Phe Xaa Pro Ser Gln Phe Ala Xaa Xaa 
1               5                   10          


<210>  12
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial peptide composition


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is norleucine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is 
       (s)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is D-alanine

<400>  12

Ala Gly Tyr Phe Xaa Pro Thr Asn Phe Ala Xaa Xaa 
1               5                   10          


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial peptide composition


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is norleucine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is 
       (s)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is D-alanine

<400>  13

Ala Ala Phe Tyr Xaa Pro Thr Gln Phe Ala Xaa Xaa 
1               5                   10          


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial peptide composition


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is norleucine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is D-alanine

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is D-alanine

<400>  14

Ala Ala Tyr Phe Xaa Pro Ser Gln Tyr Xaa Phe Xaa 
1               5                   10          


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial peptide composition


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is D-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is D-norleucine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is D-serine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is D-alanine

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is D-alanine

<400>  15

Ala Gly Xaa Tyr Xaa Pro Xaa Gln Phe Xaa Phe Xaa 
1               5                   10          


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial peptide composition


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is D-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is D-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is norleucine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is D-serine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is alpha-aminoadipic acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is D-alanine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is 
       (s)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is D-alanine

<400>  16

Xaa Gly Xaa Tyr Xaa Pro Xaa Xaa Phe Xaa Xaa Xaa 
1               5                   10          


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial peptide composition


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is D-alanine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is D-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is norleucine

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is D-serine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is alpha-aminoadipic acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is D-alanine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is 
       (s)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is D-alanine

<400>  17

Xaa Gly Xaa Phe Xaa Pro Xaa Xaa Phe Xaa Xaa Xaa 
1               5                   10          


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial peptide composition


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is norleucine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is 
       (s)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is D-alanine

<400>  18

Ala Gly Phe Phe Xaa Pro Ser Gln Phe Ala Xaa Xaa 
1               5                   10          


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial peptide composition


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is norleucine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa at position 11 is 
       (s)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is D-serine

<400>  19

Gly Gly Phe Phe Xaa Pro Ser Gln Phe Ala Xaa Xaa 
1               5                   10          


