                         SEQUENCE LISTING

<110>  Ludwig Institute for Cancer Research Ltd.
       Walton, Zandra
       Stine, Zachary
       Gong, Yaoyu
       Dang, Chi Van
 
<120>  NATURAL KILLER CELLS WITH ENHANCED CYTOTOXICITY AND METHODS OF 
       USE THEREOF

<130>  084276.00269

<150>  62/879,220
<151>  2019-07-26

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Gln Ser Lys Ser Arg Lys Ile Ala Ile Leu Gly Tyr Arg Ser 
1               5                   10                  15      


Val Gly Lys Ser Ser Leu Thr Ile Gln Phe Val Glu Gly Gln Phe Val 
            20                  25                  30          


Asp Ser Tyr Asp Pro Thr Ile Glu Asn Thr Phe Thr Lys Leu Ile Thr 
        35                  40                  45              


Val Asn Gly Gln Glu Tyr His Leu Gln Leu Val Asp Thr Ala Gly Gln 
    50                  55                  60                  


Asp Glu Tyr Ser Ile Phe Pro Gln Thr Tyr Ser Ile Asp Ile Asn Gly 
65                  70                  75                  80  


Tyr Ile Leu Val Tyr Ser Val Thr Ser Ile Lys Ser Phe Glu Val Ile 
                85                  90                  95      


Lys Val Ile His Gly Lys Leu Leu Asp Met Val Gly Lys Val Gln Ile 
            100                 105                 110         


Pro Ile Met Leu Val Gly Asn Lys Lys Asp Leu His Met Glu Arg Val 
        115                 120                 125             


Ile Ser Tyr Glu Glu Gly Lys Ala Leu Ala Glu Ser Trp Asn Ala Ala 
    130                 135                 140                 


Phe Leu Glu Ser Ser Ala Lys Glu Asn Gln Thr Ala Val Asp Val Phe 
145                 150                 155                 160 


Arg Arg Ile Ile Leu Glu Ala Glu Lys Met Asp Gly Ala Ala Ser Gln 
                165                 170                 175     


Gly Lys Ser Ser Cys Ser Val Met 
            180                 


<210>  2
<211>  192
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  2

Met Asp Tyr Lys Asp Asp Asp Asp Lys Pro Gln Ser Lys Ser Arg Lys 
1               5                   10                  15      


Ile Ala Ile Leu Gly Tyr Arg Ser Val Gly Lys Ser Ser Leu Thr Ile 
            20                  25                  30          


Gln Phe Val Glu Gly Gln Phe Val Asp Ser Tyr Asp Pro Thr Ile Glu 
        35                  40                  45              


Asn Thr Phe Thr Lys Leu Ile Thr Val Asn Gly Gln Glu Tyr His Leu 
    50                  55                  60                  


Gln Leu Val Asp Thr Ala Gly Gln Asp Glu Tyr Ser Ile Phe Pro Gln 
65                  70                  75                  80  


Thr Tyr Ser Ile Asp Ile Asn Gly Tyr Ile Leu Val Tyr Ser Val Thr 
                85                  90                  95      


Ser Ile Lys Ser Phe Glu Val Ile Lys Val Ile His Gly Lys Leu Leu 
            100                 105                 110         


Asp Met Val Gly Lys Val Gln Ile Pro Ile Met Leu Val Gly Asn Lys 
        115                 120                 125             


Lys Asp Leu His Met Glu Arg Val Ile Ser Tyr Glu Glu Gly Lys Ala 
    130                 135                 140                 


Leu Ala Glu Ser Trp Asn Ala Ala Phe Leu Glu Ser Ser Ala Lys Glu 
145                 150                 155                 160 


Thr Gln Thr Ala Val Asp Val Phe Arg Arg Ile Ile Leu Glu Ala Glu 
                165                 170                 175     


Lys Met Asp Gly Ala Ala Ser Gln Gly Lys Ser Ser Cys Ser Val Met 
            180                 185                 190         


<210>  3
<211>  603
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  3

Met Ala Ala Pro Gly Ala Arg Arg Pro Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Leu Ala His Ser Ala Pro Ala Leu Phe Glu Val Lys Asp Asn Asn 
            20                  25                  30          


Gly Thr Ala Cys Ile Met Ala Ser Phe Ser Ala Ser Phe Leu Thr Thr 
        35                  40                  45              


Tyr Glu Ala Gly His Val Ser Lys Val Ser Asn Met Thr Leu Pro Ala 
    50                  55                  60                  


Ser Ala Glu Val Leu Lys Asn Ser Ser Ser Cys Gly Glu Lys Asn Ala 
65                  70                  75                  80  


Ser Glu Pro Thr Leu Ala Ile Thr Phe Gly Glu Gly Tyr Leu Leu Lys 
                85                  90                  95      


Leu Thr Phe Thr Lys Asn Thr Thr Arg Tyr Ser Val Gln His Met Tyr 
            100                 105                 110         


Phe Thr Tyr Asn Leu Ser Asp Thr Gln Phe Phe Pro Asn Ala Ser Ser 
        115                 120                 125             


Lys Gly Pro Asp Thr Val Asp Ser Thr Thr Asp Ile Lys Ala Asp Ile 
    130                 135                 140                 


Asn Lys Thr Tyr Arg Cys Val Ser Asp Ile Arg Val Tyr Met Lys Asn 
145                 150                 155                 160 


Val Thr Ile Val Leu Trp Asp Ala Thr Ile Gln Ala Tyr Leu Pro Ser 
                165                 170                 175     


Ser Asn Phe Ser Lys Glu Glu Thr Arg Cys Pro Gln Asp Gln Pro Ser 
            180                 185                 190         


Pro Thr Thr Gly Pro Pro Ser Pro Ser Pro Pro Leu Val Pro Thr Asn 
        195                 200                 205             


Pro Ser Val Ser Lys Tyr Asn Val Thr Gly Asp Asn Gly Thr Cys Leu 
    210                 215                 220                 


Leu Ala Ser Met Ala Leu Gln Leu Asn Ile Thr Tyr Met Lys Lys Asp 
225                 230                 235                 240 


Asn Thr Thr Val Thr Arg Ala Phe Asn Ile Asn Pro Ser Asp Lys Tyr 
                245                 250                 255     


Ser Gly Thr Cys Gly Ala Gln Leu Val Thr Leu Lys Val Gly Asn Lys 
            260                 265                 270         


Ser Arg Val Leu Glu Leu Gln Phe Gly Met Asn Ala Thr Ser Ser Leu 
        275                 280                 285             


Phe Phe Leu Gln Gly Val Gln Leu Asn Met Thr Leu Pro Asp Ala Ile 
    290                 295                 300                 


Glu Pro Thr Phe Ser Thr Ser Asn Tyr Ser Leu Lys Ala Leu Gln Ala 
305                 310                 315                 320 


Ser Val Gly Asn Ser Tyr Lys Cys Asn Ser Glu Glu His Ile Phe Val 
                325                 330                 335     


Ser Lys Ala Leu Ala Leu Asn Val Phe Ser Val Gln Val Gln Ala Phe 
            340                 345                 350         


Arg Val Glu Ser Asp Arg Phe Gly Ser Val Glu Glu Cys Val Gln Asp 
        355                 360                 365             


Gly Asn Asn Met Leu Ile Pro Ile Ala Val Gly Gly Ala Leu Ala Gly 
    370                 375                 380                 


Leu Val Leu Ile Val Leu Ile Ala Tyr Leu Ile Gly Arg Lys Arg Ser 
385                 390                 395                 400 


His Ala Gly Tyr Gln Thr Ile Gly Gly Gly Thr Met Asp Tyr Lys Asp 
                405                 410                 415     


Asp Asp Asp Lys Pro Gln Ser Lys Ser Arg Lys Ile Ala Ile Leu Gly 
            420                 425                 430         


Tyr Arg Ser Val Gly Lys Ser Ser Leu Thr Ile Gln Phe Val Glu Gly 
        435                 440                 445             


Gln Phe Val Asp Ser Tyr Asp Pro Thr Ile Glu Asn Thr Phe Thr Lys 
    450                 455                 460                 


Leu Ile Thr Val Asn Gly Gln Glu Tyr His Leu Gln Leu Val Asp Thr 
465                 470                 475                 480 


Ala Gly Gln Asp Glu Tyr Ser Ile Phe Pro Gln Thr Tyr Ser Ile Asp 
                485                 490                 495     


Ile Asn Gly Tyr Ile Leu Val Tyr Ser Val Thr Ser Ile Lys Ser Phe 
            500                 505                 510         


Glu Val Ile Lys Val Ile His Gly Lys Leu Leu Asp Met Val Gly Lys 
        515                 520                 525             


Val Gln Ile Pro Ile Met Leu Val Gly Asn Lys Lys Asp Leu His Met 
    530                 535                 540                 


Glu Arg Val Ile Ser Tyr Glu Glu Gly Lys Ala Leu Ala Glu Ser Trp 
545                 550                 555                 560 


Asn Ala Ala Phe Leu Glu Ser Ser Ala Lys Glu Thr Gln Thr Ala Val 
                565                 570                 575     


Asp Val Phe Arg Arg Ile Ile Leu Glu Ala Glu Lys Met Asp Gly Ala 
            580                 585                 590         


Ala Ser Gln Gly Lys Ser Ser Cys Ser Val Met 
        595                 600             


<210>  4
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Pro Leu Cys Pro Ser Pro Trp Leu Pro Leu Leu Ile Pro Ala 
1               5                   10                  15      


Pro Ala Pro Gly Leu Thr Val Gln Leu Leu Leu Ser Leu Leu Leu Leu 
            20                  25                  30          


Val Pro Val His Pro Gln Arg Leu Pro Arg Met Gln Glu Asp Ser Pro 
        35                  40                  45              


Leu Gly Gly Gly Ser Ser Gly Glu Asp Asp Pro Leu Gly Glu Glu Asp 
    50                  55                  60                  


Leu Pro Ser Glu Glu Asp Ser Pro Arg Glu Glu Asp Pro Pro Gly Glu 
65                  70                  75                  80  


Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro Gly Glu Glu Asp Leu Pro 
                85                  90                  95      


Glu Val Lys Pro Lys Ser Glu Glu Glu Gly Ser Leu Lys Leu Glu Asp 
            100                 105                 110         


Leu Pro Thr Val Glu Ala Pro Gly Asp Pro Gln Glu Pro Gln Asn Asn 
        115                 120                 125             


Ala His Arg Asp Lys Glu Gly Asp Asp Gln Ser His Trp Arg Tyr Gly 
    130                 135                 140                 


Gly Asp Pro Pro Trp Pro Arg Val Ser Pro Ala Cys Ala Gly Arg Phe 
145                 150                 155                 160 


Gln Ser Pro Val Asp Ile Arg Pro Gln Leu Ala Ala Phe Cys Pro Ala 
                165                 170                 175     


Leu Arg Pro Leu Glu Leu Leu Gly Phe Gln Leu Pro Pro Leu Pro Glu 
            180                 185                 190         


Leu Arg Leu Arg Asn Asn Gly His Ser Val Gln Leu Thr Leu Pro Pro 
        195                 200                 205             


Gly Leu Glu Met Ala Leu Gly Pro Gly Arg Glu Tyr Arg Ala Leu Gln 
    210                 215                 220                 


Leu His Leu His Trp Gly Ala Ala Gly Arg Pro Gly Ser Glu His Thr 
225                 230                 235                 240 


Val Glu Gly His Arg Phe Pro Ala Glu Ile His Val Val His Leu Ser 
                245                 250                 255     


Thr Ala Phe Ala Arg Val Asp Glu Ala Leu Gly Arg Pro Gly Gly Leu 
            260                 265                 270         


Ala Val Leu Ala Ala Phe Leu Glu Glu Gly Pro Glu Glu Asn Ser Ala 
        275                 280                 285             


Tyr Glu Gln Leu Leu Ser Arg Leu Glu Glu Ile Ala Glu Glu Gly Ser 
    290                 295                 300                 


Glu Thr Gln Val Pro Gly Leu Asp Ile Ser Ala Leu Leu Pro Ser Asp 
305                 310                 315                 320 


Phe Ser Arg Tyr Phe Gln Tyr Glu Gly Ser Leu Thr Thr Pro Pro Cys 
                325                 330                 335     


Ala Gln Gly Val Ile Trp Thr Val Phe Asn Gln Thr Val Met Leu Ser 
            340                 345                 350         


Ala Lys Gln Leu His Thr Leu Ser Asp Thr Leu Trp Gly Pro Gly Asp 
        355                 360                 365             


Ser Arg Leu Gln Leu Asn Phe Arg Ala Thr Gln Pro Leu Asn Gly Arg 
    370                 375                 380                 


Val Ile Glu Ala Ser Phe Pro Ala Gly Val Asp Ser Ser Pro Arg Ala 
385                 390                 395                 400 


Ala Glu Pro Val Gln Leu Asn Ser Cys Leu Ala Ala Gly Asp Ile Leu 
                405                 410                 415     


Ala Leu Val Phe Gly Leu Leu Phe Ala Val Thr Ser Val Ala Phe Leu 
            420                 425                 430         


Val Gln Met Arg Arg Gln His Arg Arg Gly Thr Lys Gly Gly Val Ser 
        435                 440                 445             


Tyr Arg Pro Ala Glu Val Ala Glu Thr Gly Ala 
    450                 455                 


<210>  5
<211>  815
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Val Leu Arg Ser Gly Ile Cys Gly Leu Ser Pro His Arg Ile Phe 
1               5                   10                  15      


Pro Ser Leu Leu Val Val Val Ala Leu Val Gly Leu Leu Pro Val Leu 
            20                  25                  30          


Arg Ser His Gly Leu Gln Leu Ser Pro Thr Ala Ser Thr Ile Arg Ser 
        35                  40                  45              


Ser Glu Pro Pro Arg Glu Arg Ser Ile Gly Asp Val Thr Thr Ala Pro 
    50                  55                  60                  


Pro Glu Val Thr Pro Glu Ser Arg Pro Val Asn His Ser Val Thr Asp 
65                  70                  75                  80  


His Gly Met Lys Pro Arg Lys Ala Phe Pro Val Leu Gly Ile Asp Tyr 
                85                  90                  95      


Thr His Val Arg Thr Pro Phe Glu Ile Ser Leu Trp Ile Leu Leu Ala 
            100                 105                 110         


Cys Leu Met Lys Ile Gly Phe His Val Ile Pro Thr Ile Ser Ser Ile 
        115                 120                 125             


Val Pro Glu Ser Cys Leu Leu Ile Val Val Gly Leu Leu Val Gly Gly 
    130                 135                 140                 


Leu Ile Lys Gly Val Gly Glu Thr Pro Pro Phe Leu Gln Ser Asp Val 
145                 150                 155                 160 


Phe Phe Leu Phe Leu Leu Pro Pro Ile Ile Leu Asp Ala Gly Tyr Phe 
                165                 170                 175     


Leu Pro Leu Arg Gln Phe Thr Glu Asn Leu Gly Thr Ile Leu Ile Phe 
            180                 185                 190         


Ala Val Val Gly Thr Leu Trp Asn Ala Phe Phe Leu Gly Gly Leu Met 
        195                 200                 205             


Tyr Ala Val Cys Leu Val Gly Gly Glu Gln Ile Asn Asn Ile Gly Leu 
    210                 215                 220                 


Leu Asp Asn Leu Leu Phe Gly Ser Ile Ile Ser Ala Val Asp Pro Val 
225                 230                 235                 240 


Ala Val Leu Ala Val Phe Glu Glu Ile His Ile Asn Glu Leu Leu His 
                245                 250                 255     


Ile Leu Val Phe Gly Glu Ser Leu Leu Asn Asp Ala Val Thr Val Val 
            260                 265                 270         


Leu Tyr His Leu Phe Glu Glu Phe Ala Asn Tyr Glu His Val Gly Ile 
        275                 280                 285             


Val Asp Ile Phe Leu Gly Phe Leu Ser Phe Phe Val Val Ala Leu Gly 
    290                 295                 300                 


Gly Val Leu Val Gly Val Val Tyr Gly Val Ile Ala Ala Phe Thr Ser 
305                 310                 315                 320 


Arg Phe Thr Ser His Ile Arg Val Ile Glu Pro Leu Phe Val Phe Leu 
                325                 330                 335     


Tyr Ser Tyr Met Ala Tyr Leu Ser Ala Glu Leu Phe His Leu Ser Gly 
            340                 345                 350         


Ile Met Ala Leu Ile Ala Ser Gly Val Val Met Arg Pro Tyr Val Glu 
        355                 360                 365             


Ala Asn Ile Ser His Lys Ser His Thr Thr Ile Lys Tyr Phe Leu Lys 
    370                 375                 380                 


Met Trp Ser Ser Val Ser Glu Thr Leu Ile Phe Ile Phe Leu Gly Val 
385                 390                 395                 400 


Ser Thr Val Ala Gly Ser His His Trp Asn Trp Thr Phe Val Ile Ser 
                405                 410                 415     


Thr Leu Leu Phe Cys Leu Ile Ala Arg Val Leu Gly Val Leu Gly Leu 
            420                 425                 430         


Thr Trp Phe Ile Asn Lys Phe Arg Ile Val Lys Leu Thr Pro Lys Asp 
        435                 440                 445             


Gln Phe Ile Ile Ala Tyr Gly Gly Leu Arg Gly Ala Ile Ala Phe Ser 
    450                 455                 460                 


Leu Gly Tyr Leu Leu Asp Lys Lys His Phe Pro Met Cys Asp Leu Phe 
465                 470                 475                 480 


Leu Thr Ala Ile Ile Thr Val Ile Phe Phe Thr Val Phe Val Gln Gly 
                485                 490                 495     


Met Thr Ile Arg Pro Leu Val Asp Leu Leu Ala Val Lys Lys Lys Gln 
            500                 505                 510         


Glu Thr Lys Arg Ser Ile Asn Glu Glu Ile His Thr Gln Phe Leu Asp 
        515                 520                 525             


His Leu Leu Thr Gly Ile Glu Asp Ile Cys Gly His Tyr Gly His His 
    530                 535                 540                 


His Trp Lys Asp Lys Leu Asn Arg Phe Asn Lys Lys Tyr Val Lys Lys 
545                 550                 555                 560 


Cys Leu Ile Ala Gly Glu Arg Ser Lys Glu Pro Gln Leu Ile Ala Phe 
                565                 570                 575     


Tyr His Lys Met Glu Met Lys Gln Ala Ile Glu Leu Val Glu Ser Gly 
            580                 585                 590         


Gly Met Gly Lys Ile Pro Ser Ala Val Ser Thr Val Ser Met Gln Asn 
        595                 600                 605             


Ile His Pro Lys Ser Leu Pro Ser Glu Arg Ile Leu Pro Ala Leu Ser 
    610                 615                 620                 


Lys Asp Lys Glu Glu Glu Ile Arg Lys Ile Leu Arg Asn Asn Leu Gln 
625                 630                 635                 640 


Lys Thr Arg Gln Arg Leu Arg Ser Tyr Asn Arg His Thr Leu Val Ala 
                645                 650                 655     


Asp Pro Tyr Glu Glu Ala Trp Asn Gln Met Leu Leu Arg Arg Gln Lys 
            660                 665                 670         


Ala Arg Gln Leu Glu Gln Lys Ile Asn Asn Tyr Leu Thr Val Pro Ala 
        675                 680                 685             


His Lys Leu Asp Ser Pro Thr Met Ser Arg Ala Arg Ile Gly Ser Asp 
    690                 695                 700                 


Pro Leu Ala Tyr Glu Pro Lys Glu Asp Leu Pro Val Ile Thr Ile Asp 
705                 710                 715                 720 


Pro Ala Ser Pro Gln Ser Pro Glu Ser Val Asp Leu Val Asn Glu Glu 
                725                 730                 735     


Leu Lys Gly Lys Val Leu Gly Leu Ser Arg Asp Pro Ala Lys Val Ala 
            740                 745                 750         


Glu Glu Asp Glu Asp Asp Asp Gly Gly Ile Met Met Arg Ser Lys Glu 
        755                 760                 765             


Thr Ser Ser Pro Gly Thr Asp Asp Val Phe Thr Pro Ala Pro Ser Asp 
    770                 775                 780                 


Ser Pro Ser Ser Gln Arg Ile Gln Arg Cys Leu Ser Asp Pro Gly Pro 
785                 790                 795                 800 


His Pro Glu Pro Gly Glu Gly Glu Pro Phe Phe Pro Lys Gly Gln 
                805                 810                 815 


<210>  6
<211>  815
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  6

Met Val Leu Arg Ser Gly Ile Cys Gly Leu Ser Pro His Arg Ile Phe 
1               5                   10                  15      


Pro Ser Leu Leu Val Val Val Ala Leu Val Gly Leu Leu Pro Val Leu 
            20                  25                  30          


Arg Ser His Gly Leu Gln Leu Ser Pro Thr Ala Ser Thr Ile Arg Ser 
        35                  40                  45              


Ser Glu Pro Pro Arg Glu Arg Ser Ile Gly Asp Val Thr Thr Ala Pro 
    50                  55                  60                  


Pro Glu Val Thr Pro Glu Ser Arg Pro Val Asn His Ser Val Thr Asp 
65                  70                  75                  80  


His Gly Met Lys Pro Arg Lys Ala Phe Pro Val Leu Gly Ile Asp Tyr 
                85                  90                  95      


Thr His Val Arg Thr Pro Phe Glu Ile Ser Leu Trp Ile Leu Leu Ala 
            100                 105                 110         


Cys Leu Met Lys Ile Gly Phe His Val Ile Pro Thr Ile Ser Ser Ile 
        115                 120                 125             


Val Pro Glu Ser Cys Leu Leu Ile Val Val Gly Leu Leu Val Gly Gly 
    130                 135                 140                 


Leu Ile Lys Gly Val Gly Glu Thr Pro Pro Phe Leu Gln Ser Asp Val 
145                 150                 155                 160 


Phe Phe Leu Phe Leu Leu Pro Pro Ile Ile Leu Asp Ala Gly Tyr Phe 
                165                 170                 175     


Leu Pro Leu Arg Gln Phe Thr Glu Asn Leu Gly Thr Ile Leu Ile Phe 
            180                 185                 190         


Ala Val Val Gly Thr Leu Trp Asn Ala Phe Phe Leu Gly Gly Leu Met 
        195                 200                 205             


Tyr Ala Val Cys Leu Val Gly Gly Glu Gln Ile Asn Asn Ile Gly Leu 
    210                 215                 220                 


Leu Asp Asn Leu Leu Phe Gly Ser Ile Ile Ser Ala Val Asp Pro Val 
225                 230                 235                 240 


Ala Val Leu Ala Val Phe Glu Glu Ile His Ile Asn Glu Leu Leu His 
                245                 250                 255     


Ile Leu Val Phe Gly Glu Ser Leu Leu Asn Asp Ala Val Thr Val Val 
            260                 265                 270         


Leu Tyr His Leu Phe Glu Glu Phe Ala Asn Tyr Glu His Val Gly Ile 
        275                 280                 285             


Val Asp Ile Phe Leu Gly Phe Leu Ser Phe Phe Val Val Ala Leu Gly 
    290                 295                 300                 


Gly Val Leu Val Gly Val Val Tyr Gly Val Ile Ala Ala Phe Thr Ser 
305                 310                 315                 320 


Arg Phe Thr Ser His Ile Arg Val Ile Glu Pro Leu Phe Val Phe Leu 
                325                 330                 335     


Tyr Ser Tyr Met Ala Tyr Leu Ser Ala Glu Leu Phe His Leu Ser Gly 
            340                 345                 350         


Ile Met Ala Leu Ile Ala Ser Gly Val Val Met Arg Pro Tyr Val Glu 
        355                 360                 365             


Ala Asn Ile Ser His Lys Ser His Thr Thr Ile Lys Tyr Phe Leu Lys 
    370                 375                 380                 


Met Trp Ser Ser Val Ser Glu Thr Leu Ile Phe Ile Phe Leu Gly Val 
385                 390                 395                 400 


Ser Thr Val Ala Gly Ser His His Trp Asn Trp Thr Phe Val Ile Ser 
                405                 410                 415     


Thr Leu Leu Phe Cys Leu Ile Ala Arg Val Leu Gly Val Leu Gly Leu 
            420                 425                 430         


Thr Trp Phe Ile Asn Lys Phe Arg Ile Val Lys Leu Thr Pro Lys Asp 
        435                 440                 445             


Gln Phe Ile Ile Ala Tyr Gly Gly Leu Arg Gly Ala Ile Ala Phe Ser 
    450                 455                 460                 


Leu Gly Tyr Leu Leu Asp Lys Lys His Phe Pro Met Cys Asp Leu Phe 
465                 470                 475                 480 


Leu Thr Ala Ile Ile Thr Val Ile Phe Phe Thr Val Phe Val Gln Gly 
                485                 490                 495     


Met Thr Ile Arg Pro Leu Val Asp Leu Leu Ala Val Lys Lys Lys Gln 
            500                 505                 510         


Glu Thr Lys Arg Ser Ile Asn Glu Glu Ile His Thr Gln Phe Leu Asp 
        515                 520                 525             


His Leu Leu Thr Gly Ile Glu Asp Ile Cys Gly Arg Tyr Gly Arg Arg 
    530                 535                 540                 


Arg Trp Lys Asp Lys Leu Asn Arg Phe Asn Lys Lys Tyr Val Lys Lys 
545                 550                 555                 560 


Cys Leu Ile Ala Gly Glu Arg Ser Lys Glu Pro Gln Leu Ile Ala Phe 
                565                 570                 575     


Tyr His Lys Met Glu Met Lys Gln Ala Ile Glu Leu Val Glu Ser Gly 
            580                 585                 590         


Gly Met Gly Lys Ile Pro Ser Ala Val Ser Thr Val Ser Met Gln Asn 
        595                 600                 605             


Ile His Pro Lys Ser Leu Pro Ser Glu Arg Ile Leu Pro Ala Leu Ser 
    610                 615                 620                 


Lys Asp Lys Glu Glu Glu Ile Arg Lys Ile Leu Arg Asn Asn Leu Gln 
625                 630                 635                 640 


Lys Thr Arg Gln Arg Leu Arg Ser Tyr Asn Arg His Thr Leu Val Ala 
                645                 650                 655     


Asp Pro Tyr Glu Glu Ala Trp Asn Gln Met Leu Leu Arg Arg Gln Lys 
            660                 665                 670         


Ala Arg Gln Leu Glu Gln Lys Ile Asn Asn Tyr Leu Thr Val Pro Ala 
        675                 680                 685             


His Lys Leu Asp Ser Pro Thr Met Ser Arg Ala Arg Ile Gly Ser Asp 
    690                 695                 700                 


Pro Leu Ala Tyr Glu Pro Lys Glu Asp Leu Pro Val Ile Thr Ile Asp 
705                 710                 715                 720 


Pro Ala Ser Pro Gln Ser Pro Glu Ser Val Asp Leu Val Asn Glu Glu 
                725                 730                 735     


Leu Lys Gly Lys Val Leu Gly Leu Ser Arg Asp Pro Ala Lys Val Ala 
            740                 745                 750         


Glu Glu Asp Glu Asp Asp Asp Gly Gly Ile Met Met Arg Ser Lys Glu 
        755                 760                 765             


Thr Ser Ser Pro Gly Thr Asp Asp Val Phe Thr Pro Ala Pro Ser Asp 
    770                 775                 780                 


Ser Pro Ser Ser Gln Arg Ile Gln Arg Cys Leu Ser Asp Pro Gly Pro 
785                 790                 795                 800 


His Pro Glu Pro Gly Glu Gly Glu Pro Phe Phe Pro Lys Gly Gln 
                805                 810                 815 


<210>  7
<211>  555
<212>  DNA
<213>  Homo sapiens

<400>  7
atgccgcagt ccaagtcccg gaagatcgcg atcctgggct accggtctgt ggggaaatcc       60

tcattgacga ttcaatttgt tgaaggccaa tttgtggact cctacgatcc aaccatagaa      120

aacactttta caaagttgat cacagtaaat ggacaagaat atcatcttca acttgtagac      180

acagccgggc aagatgaata ttctatcttt cctcagacat actccataga tattaatggc      240

tatattcttg tgtattctgt tacatcaatc aaaagttttg aagtgattaa agttatccat      300

ggcaaattgt tggatatggt ggggaaagta caaataccta ttatgttggt tgggaataag      360

aaagacctgc atatggaaag ggtgatcagt tatgaagaag ggaaagcttt ggcagaatct      420

tggaatgcag cttttttgga atcttctgct aaagaaaatc agactgctgt ggatgttttt      480

cgaaggataa ttttggaggc agaaaaaatg gacggggcag cttcacaagg caagtcttca      540

tgctcggtga tgtga                                                       555


<210>  8
<211>  579
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  8
atggattaca aggatgacga tgacaagccg cagtccaagt cccggaagat cgcgatcctg       60

ggctaccggt ctgtggggaa atcctcattg acgattcaat ttgttgaagg ccaatttgtg      120

gactcctacg atccaaccat agaaaacact tttacaaagt tgatcacagt aaatggacaa      180

gaatatcatc ttcaacttgt agacacagcc gggcaagatg aatattctat ctttcctcag      240

acatactcca tagatattaa tggctatatt cttgtgtatt ctgttacatc aatcaaaagt      300

tttgaagtga ttaaagttat ccatggcaaa ttgttggata tggtggggaa agtacaaata      360

cctattatgt tggttgggaa taagaaagac ctgcatatgg aaagggtgat cagttatgaa      420

gaagggaaag ctttggcaga atcttggaat gcagcttttt tggaatcttc tgctaaagaa      480

actcagactg ctgtggatgt ttttcgaagg ataattttgg aggcagaaaa aatggacggg      540

gcagcttcac aaggcaagtc ttcatgctcg gtgatgtga                             579


<210>  9
<211>  1812
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  9
atggcggccc cgggcgcccg gcggccgctg ctcctgttgc tgctggcagg ccttgcacac       60

agcgccccag cactgttcga ggtgaaagac aacaacggca cagcgtgtat aatggccagc      120

ttctctgcct cctttctgac cacctatgag gctggacatg tttctaaggt ctcgaatatg      180

accctgccag cctctgcaga agtcctgaag aatagcagct cttgtggtga aaagaatgct      240

tctgagccca ccctcgcaat cacctttgga gaaggatatt tactgaaact caccttcaca      300

aaaaacacaa cacgttacag tgtccagcac atgtatttca catataacct gtcagacaca      360

caattctttc ccaatgccag ctccaaaggg cccgacactg tggattccac aactgacatc      420

aaggcagaca tcaacaaaac ataccgatgt gtcagcgaca tcagggtcta catgaagaat      480

gtgaccattg tgctctggga cgctactatc caggcctacc tgccgagtag caacttcagc      540

aaggaagaga cacgctgccc acaggatcaa ccttccccaa ctactgggcc acccagcccc      600

tcaccaccac ttgtgcccac aaaccccagt gtgtccaagt acaatgtgac tggtgacaat      660

ggaacctgcc tgctggcctc tatggcactg caactcaaca tcacctacat gaagaaggac      720

aacacgactg tgaccagagc attcaacatc aacccaagtg acaaatatag tgggacttgc      780

ggtgcccagt tggtgaccct gaaggtgggg aacaagagca gagtcctgga gctgcagttt      840

gggatgaatg ccacttctag cctgtttttc ctgcaaggag ttcagttgaa catgactctt      900

cctgatgcca tagagcccac gttcagcacc tccaactatt ccctgaaagc tcttcaggcc      960

agtgtcggca actcatacaa gtgcaacagt gaggagcaca tctttgtcag caaggcgctc     1020

gccctcaatg tcttcagcgt gcaagtccag gctttcaggg tagaaagtga caggtttggg     1080

tctgtggaag agtgtgtaca ggacggtaac aacatgctga tccccattgc tgtgggcggg     1140

gccctggcag ggctggtcct catcgtcctc atcgcctacc tcatcggcag gaagaggagt     1200

cacgcgggct atcagaccat cggaggcggc accatggatt acaaggatga cgatgacaag     1260

ccgcagtcca agtcccggaa gatcgcgatc ctgggctacc ggtctgtggg gaaatcctca     1320

ttgacgattc aatttgttga aggccaattt gtggactcct acgatccaac catagaaaac     1380

acttttacaa agttgatcac agtaaatgga caagaatatc atcttcaact tgtagacaca     1440

gccgggcaag atgaatattc tatctttcct cagacatact ccatagatat taatggctat     1500

attcttgtgt attctgttac atcaatcaaa agttttgaag tgattaaagt tatccatggc     1560

aaattgttgg atatggtggg gaaagtacaa atacctatta tgttggttgg gaataagaaa     1620

gacctgcata tggaaagggt gatcagttat gaagaaggga aagctttggc agaatcttgg     1680

aatgcagctt ttttggaatc ttctgctaaa gaaactcaga ctgctgtgga tgtttttcga     1740

aggataattt tggaggcaga aaaaatggac ggggcagctt cacaaggcaa gtcttcatgc     1800

tcggtgatgt ga                                                         1812


<210>  10
<211>  1380
<212>  DNA
<213>  Homo sapiens

<400>  10
atggctcccc tgtgccccag cccctggctc cctctgttga tcccggcccc tgctccaggc       60

ctcactgtgc aactgctgct gtcactgctg cttctggtgc ctgtccatcc ccagaggttg      120

ccccggatgc aggaggattc ccccttggga ggaggctctt ctggggaaga tgacccactg      180

ggcgaggagg atctgcccag tgaagaggat tcacccagag aggaggatcc acccggagag      240

gaggatctac ctggagagga ggatctacct ggagaggagg atctacctga agttaagcct      300

aaatcagaag aagagggctc cctgaagtta gaggatctac ctactgttga ggctcctgga      360

gatcctcaag aaccccagaa taatgcccac agggacaaag aaggggatga ccagagtcat      420

tggcgctatg gaggcgaccc gccctggccc cgggtgtccc cagcctgcgc gggccgcttc      480

cagtccccgg tggatatccg cccccagctc gccgccttct gcccggccct gcgccccctg      540

gaactcctgg gcttccagct cccgccgctc ccagaactgc gcctgcgcaa caatggccac      600

agtgtgcaac tgaccctgcc tcctgggcta gagatggctc tgggtcccgg gcgggagtac      660

cgggctctgc agctgcatct gcactggggg gctgcaggtc gtccgggctc ggagcacact      720

gtggaaggcc accgtttccc tgccgagatc cacgtggttc acctcagcac cgcctttgcc      780

agagttgacg aggccttggg gcgcccggga ggcctggccg tgttggccgc ctttctggag      840

gagggcccgg aagaaaacag tgcctatgag cagttgctgt ctcgcttgga agaaatcgct      900

gaggaaggct cagagactca ggtcccagga ctggacatat ctgcactcct gccctctgac      960

ttcagccgct acttccaata tgaggggtct ctgactacac cgccctgtgc ccagggtgtc     1020

atctggactg tgtttaacca gacagtgatg ctgagtgcta agcagctcca caccctctct     1080

gacaccctgt ggggacctgg tgactctcgg ctacagctga acttccgagc gacgcagcct     1140

ttgaatgggc gagtgattga ggcctccttc cctgctggag tggacagcag tcctcgggct     1200

gctgagccag tccagctgaa ttcctgcctg gctgctggtg acatcctagc cctggttttt     1260

ggcctccttt ttgctgtcac cagcgtcgcg ttccttgtgc agatgagaag gcagcacaga     1320

aggggaacca aagggggtgt gagctaccgc ccagcagagg tagccgagac tggagcctag     1380


<210>  11
<211>  2448
<212>  DNA
<213>  Homo sapiens

<400>  11
atggtgctga ggagtggtat ctgcggcctg tccccccata ggatatttcc aagtttgctt       60

gtagttgtag ctctcgtcgg attgctccct gttctgcgct ctcacggact gcaactgtct      120

ccgactgctt ccactattcg gtcatctgag ccaccgcgcg agaggagcat cggggatgtt      180

actacagcac caccagaggt cacccccgag tcacgaccag tgaaccactc cgtcactgat      240

catgggatga agccgcggaa ggctttcccc gtgctcggga ttgattacac gcatgtacgg      300

acaccttttg aaatctcact ctggatcctg ttggcgtgtc tcatgaaaat cgggtttcat      360

gtaataccga cgatttcttc catcgtgcca gagtcttgtc tcctcattgt ggtcggtctc      420

ctcgttggcg gtctcatcaa gggagttggc gagacaccgc cgtttttgca atcagatgta      480

ttctttttgt ttcttctgcc cccaataatt cttgatgcag ggtatttctt gccgctcaga      540

cagtttactg agaaccttgg gactatactt atattcgcgg tagtaggaac cctctggaac      600

gcctttttcc tgggagggtt gatgtacgct gtatgtctcg tcggtggaga gcaaattaac      660

aatattggtc tgttggacaa tcttttgttc ggctccataa tcagcgctgt cgatccagtc      720

gccgtgctcg ctgtattcga ggaaatccac atcaacgaac ttcttcatat actcgttttc      780

ggtgaaagtc ttctcaatga tgccgtgact gtagttcttt accatctctt cgaagagttc      840

gccaactatg agcacgttgg aatagtcgat attttccttg ggtttctctc tttcttcgtc      900

gttgccctcg gaggagtctt ggtaggcgtc gtctacggcg tcatagcagc ctttacttct      960

aggtttacgt ctcacatacg cgtgattgag ccgttgtttg tttttctgta ttcctatatg     1020

gcctatttga gtgccgagct ttttcatctt agcggtataa tggcccttat cgcgtctggg     1080

gttgtcatgc gcccatatgt cgaggcgaat ataagtcaca aatcccatac cacgattaaa     1140

tatttcctca aaatgtggtc aagcgtttca gaaaccctta tattcatatt cctgggagtc     1200

agcacagtag cgggctccca tcactggaac tggacattcg taatatctac gttgctcttt     1260

tgcctgatag ccagagttct gggcgtgctc ggactgactt ggtttattaa caaattcaga     1320

attgttaaac tgacgcctaa agaccagttc atcatagcat atggaggttt gcgcggggca     1380

atcgcattca gtctggggta tctcctcgac aagaagcact tccccatgtg cgatctgttt     1440

ttgaccgcga tcatcacagt catatttttt acggtttttg tacaggggat gaccatcagg     1500

ccactcgttg atcttttggc ggtcaaaaaa aaacaagaga cgaaacgaag tataaatgaa     1560

gagatacata ctcagttctt ggaccacttg ctgaccggga tagaggacat ttgtggccac     1620

tatggtcatc atcactggaa ggataaactg aatcggttta acaaaaaata tgtgaaaaaa     1680

tgcttgatcg ccggggaacg gtctaaagaa ccacagctta tagccttcta tcataaaatg     1740

gagatgaagc aggcgataga gctggtggaa tccggaggaa tgggaaagat acccagcgct     1800

gtctcaaccg tgtctatgca aaatatccat ccgaagtccc ttccatctga gcgaatcctg     1860

cccgccctca gcaaggacaa agaggaggag attcggaaaa ttctgaggaa taacttgcag     1920

aagactagac agcgcctcag atcctataac cgacacaccc tggtggccga cccctatgag     1980

gaagcctgga accagatgtt gcttcgacgg caaaaagctc gacaattgga gcaaaagatc     2040

aataactatc tcaccgtccc tgctcacaaa cttgactctc ccactatgtc tcgagccagg     2100

ataggatctg accccctggc gtacgagcca aaagaggatt tgcctgtcat tacgatagat     2160

ccggcctccc cgcagtctcc cgagtccgta gacctggtta acgaggaact taagggcaaa     2220

gttctgggcc ttagtcggga tccggcaaag gttgctgagg aggacgaaga tgatgatggg     2280

ggtattatga tgaggtcaaa agaaacaagt tcccccggta cggacgatgt attcacgccg     2340

gcgccttctg actccccaag ctctcaacgc atacagcggt gcctgagtga cccggggccc     2400

catccggagc cgggtgaagg ggagccgttt tttcctaaag gccaatag                  2448


<210>  12
<211>  2448
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  12
atggtgctga ggagtggtat ctgcggcctg tccccccata ggatatttcc aagtttgctt       60

gtagttgtag ctctcgtcgg attgctccct gttctgcgct ctcacggact gcaactgtct      120

ccgactgctt ccactattcg gtcatctgag ccaccgcgcg agaggagcat cggggatgtt      180

actacagcac caccagaggt cacccccgag tcacgaccag tgaaccactc cgtcactgat      240

catgggatga agccgcggaa ggctttcccc gtgctcggga ttgattacac gcatgtacgg      300

acaccttttg aaatctcact ctggatcctg ttggcgtgtc tcatgaaaat cgggtttcat      360

gtaataccga cgatttcttc catcgtgcca gagtcttgtc tcctcattgt ggtcggtctc      420

ctcgttggcg gtctcatcaa gggagttggc gagacaccgc cgtttttgca atcagatgta      480

ttctttttgt ttcttctgcc cccaataatt cttgatgcag ggtatttctt gccgctcaga      540

cagtttactg agaaccttgg gactatactt atattcgcgg tagtaggaac cctctggaac      600

gcctttttcc tgggagggtt gatgtacgct gtatgtctcg tcggtggaga gcaaattaac      660

aatattggtc tgttggacaa tcttttgttc ggctccataa tcagcgctgt cgatccagtc      720

gccgtgctcg ctgtattcga ggaaatccac atcaacgaac ttcttcatat actcgttttc      780

ggtgaaagtc ttctcaatga tgccgtgact gtagttcttt accatctctt cgaagagttc      840

gccaactatg agcacgttgg aatagtcgat attttccttg ggtttctctc tttcttcgtc      900

gttgccctcg gaggagtctt ggtaggcgtc gtctacggcg tcatagcagc ctttacttct      960

aggtttacgt ctcacatacg cgtgattgag ccgttgtttg tttttctgta ttcctatatg     1020

gcctatttga gtgccgagct ttttcatctt agcggtataa tggcccttat cgcgtctggg     1080

gttgtcatgc gcccatatgt cgaggcgaat ataagtcaca aatcccatac cacgattaaa     1140

tatttcctca aaatgtggtc aagcgtttca gaaaccctta tattcatatt cctgggagtc     1200

agcacagtag cgggctccca tcactggaac tggacattcg taatatctac gttgctcttt     1260

tgcctgatag ccagagttct gggcgtgctc ggactgactt ggtttattaa caaattcaga     1320

attgttaaac tgacgcctaa agaccagttc atcatagcat atggaggttt gcgcggggca     1380

atcgcattca gtctggggta tctcctcgac aagaagcact tccccatgtg cgatctgttt     1440

ttgaccgcga tcatcacagt catatttttt acggtttttg tacaggggat gaccatcagg     1500

ccactcgttg atcttttggc ggtcaaaaaa aaacaagaga cgaaacgaag tataaatgaa     1560

gagatacata ctcagttctt ggaccacttg ctgaccggga tagaggacat ttgtggccgc     1620

tatggcaggc gacgatggaa ggataaactg aatcggttta acaaaaaata tgtgaaaaaa     1680

tgcttgatcg ccggggaacg gtctaaagaa ccacagctta tagccttcta tcataaaatg     1740

gagatgaagc aggcgataga gctggtggaa tccggaggaa tgggaaagat acccagcgct     1800

gtctcaaccg tgtctatgca aaatatccat ccgaagtccc ttccatctga gcgaatcctg     1860

cccgccctca gcaaggacaa agaggaggag attcggaaaa ttctgaggaa taacttgcag     1920

aagactagac agcgcctcag atcctataac cgacacaccc tggtggccga cccctatgag     1980

gaagcctgga accagatgtt gcttcgacgg caaaaagctc gacaattgga gcaaaagatc     2040

aataactatc tcaccgtccc tgctcacaaa cttgactctc ccactatgtc tcgagccagg     2100

ataggatctg accccctggc gtacgagcca aaagaggatt tgcctgtcat tacgatagat     2160

ccggcctccc cgcagtctcc cgagtccgta gacctggtta acgaggaact taagggcaaa     2220

gttctgggcc ttagtcggga tccggcaaag gttgctgagg aggacgaaga tgatgatggg     2280

ggtattatga tgaggtcaaa agaaacaagt tcccccggta cggacgatgt attcacgccg     2340

gcgccttctg actccccaag ctctcaacgc atacagcggt gcctgagtga cccggggccc     2400

catccggagc cgggtgaagg ggagccgttt tttcctaaag gccaatag                  2448


<210>  13
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  13

Gly Gly Gly Thr Met 
1               5   


<210>  14
<211>  2
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  14

Ser Gly 
1       


<210>  15
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  15

Ser Gly Ser 
1           


<210>  16
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  16

Ser Gly Gly 
1           


<210>  17
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  17

Ser Gly Gly Ser 
1               


<210>  18
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  18

Ser Gly Gly Gly 
1               


<210>  19
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  19

Ser Gly Gly Gly Ser 
1               5   


<210>  20
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  20

Ser Gly Gly Gly Gly 
1               5   


<210>  21
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  21

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  22
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  22

Ser Gly Gly Gly Gly Gly 
1               5       


<210>  23
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  23

Ser Gly Gly Gly Gly Gly Ser 
1               5           


<210>  24
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  24

Ser Gly Gly Gly Gly Gly Gly 
1               5           


<210>  25
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  25

Ser Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   


<210>  26
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic

<400>  26
ggaggcggca ccatg                                                        15


