                               SEQUENCE LISTING

<110> SHIRE HUMAN GENETIC THERAPIES, INC.
      UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF 
      HIGHER EDUCATION
 
<120> RECOMBINANT HEME OXYGENASE-1 (HO-1) FOR THE TREATMENT OF SICKLE 
      CELL DISEASE

<130> SHR-2009WO

<140> 
<141> 

<150> 63/049,285
<151> 2020-07-08

<150> 62/879,131
<151> 2019-07-26

<160> 65    

<170> PatentIn version 3.5

<210> 1
<211> 288
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1
Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser Glu Ala 
1               5                   10                  15      


Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly Phe Lys 
        35                  40                  45              


Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu Glu Glu 
    50                  55                  60                  


Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr Phe Pro 
65                  70                  75                  80  


Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala Phe Trp 
                85                  90                  95      


Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala Met Gln 
            100                 105                 110         


Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro Glu Leu 
        115                 120                 125             


Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser Gly Gly 
    130                 135                 140                 


Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro Ser Ser 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser Ala Thr 
                165                 170                 175     


Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu Met Thr 
            180                 185                 190         


Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala Phe Leu 
        195                 200                 205             


Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr His Asp 
    210                 215                 220                 


Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg Gln Arg Ala 
225                 230                 235                 240 


Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro Arg Gly Lys 
                245                 250                 255     


Pro Pro Leu Asn Thr Arg Ser Gln Ala Pro Leu Leu Arg Trp Val Leu 
            260                 265                 270         


Thr Leu Ser Phe Leu Val Ala Thr Val Ala Val Gly Leu Tyr Ala Met 
        275                 280                 285             


<210> 2
<211> 267
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser Glu Ala 
1               5                   10                  15      


Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly Phe Lys 
        35                  40                  45              


Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu Glu Glu 
    50                  55                  60                  


Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr Phe Pro 
65                  70                  75                  80  


Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala Phe Trp 
                85                  90                  95      


Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala Met Gln 
            100                 105                 110         


Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro Glu Leu 
        115                 120                 125             


Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser Gly Gly 
    130                 135                 140                 


Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro Ser Ser 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser Ala Thr 
                165                 170                 175     


Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu Met Thr 
            180                 185                 190         


Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala Phe Leu 
        195                 200                 205             


Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr His Asp 
    210                 215                 220                 


Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg Gln Arg Ala 
225                 230                 235                 240 


Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro Arg Gly Lys 
                245                 250                 255     


Pro Pro Leu Asn Thr His His His His His His 
            260                 265         


<210> 3
<211> 261
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 3
Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser Glu Ala 
1               5                   10                  15      


Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly Phe Lys 
        35                  40                  45              


Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu Glu Glu 
    50                  55                  60                  


Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr Phe Pro 
65                  70                  75                  80  


Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala Phe Trp 
                85                  90                  95      


Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala Met Gln 
            100                 105                 110         


Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro Glu Leu 
        115                 120                 125             


Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser Gly Gly 
    130                 135                 140                 


Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro Ser Ser 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser Ala Thr 
                165                 170                 175     


Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu Met Thr 
            180                 185                 190         


Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala Phe Leu 
        195                 200                 205             


Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr His Asp 
    210                 215                 220                 


Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg Gln Arg Ala 
225                 230                 235                 240 


Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro Arg Gly Lys 
                245                 250                 255     


Pro Pro Leu Asn Thr 
            260     


<210> 4
<211> 488
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 4
Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser Glu Ala 
1               5                   10                  15      


Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly Phe Lys 
        35                  40                  45              


Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu Glu Glu 
    50                  55                  60                  


Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr Phe Pro 
65                  70                  75                  80  


Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala Phe Trp 
                85                  90                  95      


Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala Met Gln 
            100                 105                 110         


Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro Glu Leu 
        115                 120                 125             


Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser Gly Gly 
    130                 135                 140                 


Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro Ser Ser 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser Ala Thr 
                165                 170                 175     


Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu Met Thr 
            180                 185                 190         


Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala Phe Leu 
        195                 200                 205             


Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr His Asp 
    210                 215                 220                 


Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg Gln Arg Ala 
225                 230                 235                 240 


Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro Arg Gly Lys 
                245                 250                 255     


Pro Pro Leu Asn Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            260                 265                 270         


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        275                 280                 285             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    290                 295                 300                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
305                 310                 315                 320 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                325                 330                 335     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            340                 345                 350         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        355                 360                 365             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    370                 375                 380                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
385                 390                 395                 400 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                405                 410                 415     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            420                 425                 430         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        435                 440                 445             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    450                 455                 460                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
465                 470                 475                 480 


Ser Leu Ser Leu Ser Pro Gly Lys 
                485             


<210> 5
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser Glu Ala 
1               5                   10                  15      


Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly Phe Lys 
        35                  40                  45              


Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu Glu Glu 
    50                  55                  60                  


Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr Phe Pro 
65                  70                  75                  80  


Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala Phe Trp 
                85                  90                  95      


Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala Met Gln 
            100                 105                 110         


Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro Glu Leu 
        115                 120                 125             


Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser Gly Gly 
    130                 135                 140                 


Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro Ser Ser 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser Ala Thr 
                165                 170                 175     


Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu Met Thr 
            180                 185                 190         


Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala Phe Leu 
        195                 200                 205             


Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr His Asp 
    210                 215                 220                 


Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg Gln Arg Ala 
225                 230                 235                 240 


Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro Arg Gly Lys 
                245                 250                 255     


Pro Pro Leu Asn Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro 
        275                 280                 285             


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
    290                 295                 300                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
305                 310                 315                 320 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                325                 330                 335     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            340                 345                 350         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        355                 360                 365             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    370                 375                 380                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
385                 390                 395                 400 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                405                 410                 415     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            420                 425                 430         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        435                 440                 445             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    450                 455                 460                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
465                 470                 475                 480 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                485                 490                 495     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            500                 505             


<210> 6
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Met Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
1               5                   10                  15      


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Arg Pro Gln Pro Asp Ser Met 
                245                 250                 255     


Pro Gln Asp Leu Ser Glu Ala Leu Lys Glu Ala Thr Lys Glu Val His 
            260                 265                 270         


Thr Gln Ala Glu Asn Ala Glu Phe Met Arg Asn Phe Gln Lys Gly Gln 
        275                 280                 285             


Val Thr Arg Asp Gly Phe Lys Leu Val Met Ala Ser Leu Tyr His Ile 
    290                 295                 300                 


Tyr Val Ala Leu Glu Glu Glu Ile Glu Arg Asn Lys Glu Ser Pro Val 
305                 310                 315                 320 


Phe Ala Pro Val Tyr Phe Pro Glu Glu Leu His Arg Lys Ala Ala Leu 
                325                 330                 335     


Glu Gln Asp Leu Ala Phe Trp Tyr Gly Pro Arg Trp Gln Glu Val Ile 
            340                 345                 350         


Pro Tyr Thr Pro Ala Met Gln Arg Tyr Val Lys Arg Leu His Glu Val 
        355                 360                 365             


Gly Arg Thr Glu Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr 
    370                 375                 380                 


Leu Gly Asp Leu Ser Gly Gly Gln Val Leu Lys Lys Ile Ala Gln Lys 
385                 390                 395                 400 


Ala Leu Asp Leu Pro Ser Ser Gly Glu Gly Leu Ala Phe Phe Thr Phe 
                405                 410                 415     


Pro Asn Ile Ala Ser Ala Thr Lys Phe Lys Gln Leu Tyr Arg Ser Arg 
            420                 425                 430         


Met Asn Ser Leu Glu Met Thr Pro Ala Val Arg Gln Arg Val Ile Glu 
        435                 440                 445             


Glu Ala Lys Thr Ala Phe Leu Leu Asn Ile Gln Leu Phe Glu Glu Leu 
    450                 455                 460                 


Gln Glu Leu Leu Thr His Asp Thr Lys Asp Gln Ser Pro Ser Arg Ala 
465                 470                 475                 480 


Pro Gly Leu Arg Gln Arg Ala Ser Asn Lys Val Gln Asp Ser Ala Pro 
                485                 490                 495     


Val Glu Thr Pro Arg Gly Lys Pro Pro Leu Asn Thr 
            500                 505             


<210> 7
<211> 488
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 7
Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser Glu Ala 
1               5                   10                  15      


Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly Phe Lys 
        35                  40                  45              


Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu Glu Glu 
    50                  55                  60                  


Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr Phe Pro 
65                  70                  75                  80  


Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala Phe Trp 
                85                  90                  95      


Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala Met Gln 
            100                 105                 110         


Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro Glu Leu 
        115                 120                 125             


Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser Gly Gly 
    130                 135                 140                 


Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro Ser Ser 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser Ala Thr 
                165                 170                 175     


Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu Met Thr 
            180                 185                 190         


Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala Phe Leu 
        195                 200                 205             


Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr His Asp 
    210                 215                 220                 


Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg Gln Arg Ala 
225                 230                 235                 240 


Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro Arg Gly Lys 
                245                 250                 255     


Pro Pro Leu Asn Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            260                 265                 270         


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        275                 280                 285             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    290                 295                 300                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
305                 310                 315                 320 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                325                 330                 335     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            340                 345                 350         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        355                 360                 365             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    370                 375                 380                 


Arg Glu Pro Gln Val Tyr Val Tyr Pro Pro Ser Arg Asp Glu Leu Thr 
385                 390                 395                 400 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                405                 410                 415     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            420                 425                 430         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Ala Leu Val 
        435                 440                 445             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    450                 455                 460                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
465                 470                 475                 480 


Ser Leu Ser Leu Ser Pro Gly Lys 
                485             


<210> 8
<211> 227
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Val Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Leu Thr Trp Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210> 9
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 9
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Ser Arg Cys 
            20          


<210> 10
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 10
Gly Gly Gly Gly Ser 
1               5   


<210> 11
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 11
Gly Gly Gly 
1           


<210> 12
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 12
Gly Ala Pro Gly Gly Gly Gly Gly Ala Ala Ala Ala Ala Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Ala Pro 
            20      


<210> 13
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 13
Gly Ala Pro Gly Gly Gly Gly Gly Ala Ala Ala Ala Ala Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Ala Pro Gly Gly Gly Gly Gly Ala Ala Ala Ala Ala Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Ala Pro 
        35                  


<210> 14
<211> 57
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 14
Gly Ala Pro Gly Gly Gly Gly Gly Ala Ala Ala Ala Ala Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Ala Pro Gly Gly Gly Gly Gly Ala Ala Ala Ala Ala Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Ala Pro Gly Gly Gly Gly Gly Ala Ala Ala Ala 
        35                  40                  45              


Ala Gly Gly Gly Gly Gly Gly Ala Pro 
    50                  55          


<210> 15
<211> 227
<212> PRT
<213> Homo sapiens

<400> 15
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210> 16
<211> 227
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210> 17
<211> 227
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 17
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu Lys Phe His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210> 18
<211> 227
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 18
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu Lys Phe His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210> 19
<211> 232
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Fc domain sequence"

<400> 19
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210> 20
<211> 226
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Fc domain sequence"

<400> 20
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
1               5                   10                  15      


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            20                  25                  30          


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        35                  40                  45              


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    50                  55                  60                  


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
65                  70                  75                  80  


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                85                  90                  95      


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            100                 105                 110         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        115                 120                 125             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    130                 135                 140                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
145                 150                 155                 160 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                165                 170                 175     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            180                 185                 190         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        195                 200                 205             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    210                 215                 220                 


Gly Lys 
225     


<210> 21
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 21
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 22
<211> 487
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 22
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser 
225                 230                 235                 240 


Glu Ala Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn 
                245                 250                 255     


Ala Glu Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly 
            260                 265                 270         


Phe Lys Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu 
        275                 280                 285             


Glu Glu Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr 
    290                 295                 300                 


Phe Pro Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala 
305                 310                 315                 320 


Phe Trp Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala 
                325                 330                 335     


Met Gln Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro 
            340                 345                 350         


Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser 
        355                 360                 365             


Gly Gly Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro 
    370                 375                 380                 


Ser Ser Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser 
385                 390                 395                 400 


Ala Thr Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu 
                405                 410                 415     


Met Thr Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala 
            420                 425                 430         


Phe Leu Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr 
        435                 440                 445             


His Asp Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg Gln 
    450                 455                 460                 


Arg Ala Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro Arg 
465                 470                 475                 480 


Gly Lys Pro Pro Leu Asn Thr 
                485         


<210> 23
<211> 226
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 23
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210> 24
<211> 488
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 24
Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
1               5                   10                  15      


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asp Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Asp Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu 
225                 230                 235                 240 


Ser Glu Ala Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu 
                245                 250                 255     


Asn Ala Glu Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp 
            260                 265                 270         


Gly Phe Lys Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu 
        275                 280                 285             


Glu Glu Glu Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val 
    290                 295                 300                 


Tyr Phe Pro Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu 
305                 310                 315                 320 


Ala Phe Trp Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro 
                325                 330                 335     


Ala Met Gln Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu 
            340                 345                 350         


Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu 
        355                 360                 365             


Ser Gly Gly Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu 
    370                 375                 380                 


Pro Ser Ser Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala 
385                 390                 395                 400 


Ser Ala Thr Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu 
                405                 410                 415     


Glu Met Thr Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr 
            420                 425                 430         


Ala Phe Leu Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu 
        435                 440                 445             


Thr His Asp Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg 
    450                 455                 460                 


Gln Arg Ala Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro 
465                 470                 475                 480 


Arg Gly Lys Pro Pro Leu Asn Thr 
                485             


<210> 25
<211> 226
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 25
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Lys Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210> 26
<211> 487
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 26
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Glu Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Trp Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser 
225                 230                 235                 240 


Glu Ala Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn 
                245                 250                 255     


Ala Glu Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly 
            260                 265                 270         


Phe Lys Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu 
        275                 280                 285             


Glu Glu Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr 
    290                 295                 300                 


Phe Pro Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala 
305                 310                 315                 320 


Phe Trp Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala 
                325                 330                 335     


Met Gln Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro 
            340                 345                 350         


Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser 
        355                 360                 365             


Gly Gly Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro 
    370                 375                 380                 


Ser Ser Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser 
385                 390                 395                 400 


Ala Thr Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu 
                405                 410                 415     


Met Thr Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala 
            420                 425                 430         


Phe Leu Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr 
        435                 440                 445             


His Asp Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg Gln 
    450                 455                 460                 


Arg Ala Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro Arg 
465                 470                 475                 480 


Gly Lys Pro Pro Leu Asn Thr 
                485         


<210> 27
<211> 226
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 27
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Arg Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Val Ser Asp Gly Ser Phe Thr Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210> 28
<211> 487
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 28
Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser Glu Ala 
1               5                   10                  15      


Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly Phe Lys 
        35                  40                  45              


Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu Glu Glu 
    50                  55                  60                  


Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr Phe Pro 
65                  70                  75                  80  


Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala Phe Trp 
                85                  90                  95      


Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala Met Gln 
            100                 105                 110         


Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro Glu Leu 
        115                 120                 125             


Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser Gly Gly 
    130                 135                 140                 


Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro Ser Ser 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser Ala Thr 
                165                 170                 175     


Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu Met Thr 
            180                 185                 190         


Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala Phe Leu 
        195                 200                 205             


Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr His Asp 
    210                 215                 220                 


Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg Gln Arg Ala 
225                 230                 235                 240 


Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro Arg Gly Lys 
                245                 250                 255     


Pro Pro Leu Asn Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            260                 265                 270         


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        275                 280                 285             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    290                 295                 300                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
305                 310                 315                 320 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                325                 330                 335     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            340                 345                 350         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        355                 360                 365             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    370                 375                 380                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
385                 390                 395                 400 


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                405                 410                 415     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            420                 425                 430         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        435                 440                 445             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    450                 455                 460                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
465                 470                 475                 480 


Ser Leu Ser Leu Ser Pro Gly 
                485         


<210> 29
<211> 226
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 29
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210> 30
<211> 487
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 30
Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser Glu Ala 
1               5                   10                  15      


Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly Phe Lys 
        35                  40                  45              


Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu Glu Glu 
    50                  55                  60                  


Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr Phe Pro 
65                  70                  75                  80  


Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala Phe Trp 
                85                  90                  95      


Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala Met Gln 
            100                 105                 110         


Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro Glu Leu 
        115                 120                 125             


Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser Gly Gly 
    130                 135                 140                 


Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro Ser Ser 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser Ala Thr 
                165                 170                 175     


Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu Met Thr 
            180                 185                 190         


Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala Phe Leu 
        195                 200                 205             


Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr His Asp 
    210                 215                 220                 


Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg Gln Arg Ala 
225                 230                 235                 240 


Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro Arg Gly Lys 
                245                 250                 255     


Pro Pro Leu Asn Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            260                 265                 270         


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        275                 280                 285             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    290                 295                 300                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
305                 310                 315                 320 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                325                 330                 335     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            340                 345                 350         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        355                 360                 365             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    370                 375                 380                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
385                 390                 395                 400 


Glu Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                405                 410                 415     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            420                 425                 430         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        435                 440                 445             


Ser Trp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    450                 455                 460                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
465                 470                 475                 480 


Ser Leu Ser Leu Ser Pro Gly 
                485         


<210> 31
<211> 226
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 31
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Arg Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Val Ser Asp Gly Ser Phe Thr Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210> 32
<211> 452
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 32
Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser Glu Ala 
1               5                   10                  15      


Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly Phe Lys 
        35                  40                  45              


Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu Glu Glu 
    50                  55                  60                  


Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr Phe Pro 
65                  70                  75                  80  


Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala Phe Trp 
                85                  90                  95      


Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala Met Gln 
            100                 105                 110         


Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro Glu Leu 
        115                 120                 125             


Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser Gly Gly 
    130                 135                 140                 


Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro Ser Ser 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser Ala Thr 
                165                 170                 175     


Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu Met Thr 
            180                 185                 190         


Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala Phe Leu 
        195                 200                 205             


Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr His Asp 
    210                 215                 220                 


Thr Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
225                 230                 235                 240 


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Val Tyr Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Ala Leu Val Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly 
    450         


<210> 33
<211> 226
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 33
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Val Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Leu Thr Trp Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210> 34
<211> 452
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 34
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser 
225                 230                 235                 240 


Glu Ala Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn 
                245                 250                 255     


Ala Glu Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly 
            260                 265                 270         


Phe Lys Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu 
        275                 280                 285             


Glu Glu Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr 
    290                 295                 300                 


Phe Pro Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala 
305                 310                 315                 320 


Phe Trp Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala 
                325                 330                 335     


Met Gln Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro 
            340                 345                 350         


Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser 
        355                 360                 365             


Gly Gly Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro 
    370                 375                 380                 


Ser Ser Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser 
385                 390                 395                 400 


Ala Thr Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu 
                405                 410                 415     


Met Thr Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala 
            420                 425                 430         


Phe Leu Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr 
        435                 440                 445             


His Asp Thr Lys 
    450         


<210> 35
<211> 471
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 35
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu 
            20                  25                  30          


Ser Glu Ala Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu 
        35                  40                  45              


Asn Ala Glu Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp 
    50                  55                  60                  


Gly Phe Lys Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu 
65                  70                  75                  80  


Glu Glu Glu Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val 
                85                  90                  95      


Tyr Phe Pro Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu 
            100                 105                 110         


Ala Phe Trp Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro 
        115                 120                 125             


Ala Met Gln Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu 
    130                 135                 140                 


Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu 
145                 150                 155                 160 


Ser Gly Gly Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu 
                165                 170                 175     


Pro Ser Ser Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala 
            180                 185                 190         


Ser Ala Thr Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu 
        195                 200                 205             


Glu Met Thr Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr 
    210                 215                 220                 


Ala Phe Leu Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu 
225                 230                 235                 240 


Thr His Asp Thr Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly 
465                 470     


<210> 36
<211> 759
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 36
Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser Glu Ala 
1               5                   10                  15      


Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly Phe Lys 
        35                  40                  45              


Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu Glu Glu 
    50                  55                  60                  


Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr Phe Pro 
65                  70                  75                  80  


Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala Phe Trp 
                85                  90                  95      


Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala Met Gln 
            100                 105                 110         


Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro Glu Leu 
        115                 120                 125             


Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser Gly Gly 
    130                 135                 140                 


Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro Ser Ser 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser Ala Thr 
                165                 170                 175     


Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu Met Thr 
            180                 185                 190         


Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala Phe Leu 
        195                 200                 205             


Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr His Asp 
    210                 215                 220                 


Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg Gln Arg Ala 
225                 230                 235                 240 


Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro Arg Gly Lys 
                245                 250                 255     


Pro Pro Leu Asn Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            260                 265                 270         


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        275                 280                 285             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    290                 295                 300                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
305                 310                 315                 320 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                325                 330                 335     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            340                 345                 350         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        355                 360                 365             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    370                 375                 380                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
385                 390                 395                 400 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                405                 410                 415     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            420                 425                 430         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        435                 440                 445             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    450                 455                 460                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
465                 470                 475                 480 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        515                 520                 525             


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
    530                 535                 540                 


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
545                 550                 555                 560 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                565                 570                 575     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            580                 585                 590         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        595                 600                 605             


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    610                 615                 620                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
625                 630                 635                 640 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                645                 650                 655     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
            660                 665                 670         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        675                 680                 685             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    690                 695                 700                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
705                 710                 715                 720 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                725                 730                 735     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            740                 745                 750         


Ser Leu Ser Leu Ser Pro Gly 
        755                 


<210> 37
<211> 760
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 37
Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser Glu Ala 
1               5                   10                  15      


Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly Phe Lys 
        35                  40                  45              


Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu Glu Glu 
    50                  55                  60                  


Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr Phe Pro 
65                  70                  75                  80  


Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala Phe Trp 
                85                  90                  95      


Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala Met Gln 
            100                 105                 110         


Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro Glu Leu 
        115                 120                 125             


Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser Gly Gly 
    130                 135                 140                 


Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro Ser Ser 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser Ala Thr 
                165                 170                 175     


Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu Met Thr 
            180                 185                 190         


Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala Phe Leu 
        195                 200                 205             


Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr His Asp 
    210                 215                 220                 


Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg Gln Arg Ala 
225                 230                 235                 240 


Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro Arg Gly Lys 
                245                 250                 255     


Pro Pro Leu Asn Thr Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Lys Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly 
465                 470                 475                 480 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                485                 490                 495     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        515                 520                 525             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro 
    530                 535                 540                 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
545                 550                 555                 560 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                565                 570                 575     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            580                 585                 590         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        595                 600                 605             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    610                 615                 620                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
625                 630                 635                 640 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                645                 650                 655     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            660                 665                 670         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Asp Gly Phe Tyr Pro 
        675                 680                 685             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    690                 695                 700                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
705                 710                 715                 720 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                725                 730                 735     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            740                 745                 750         


Lys Ser Leu Ser Leu Ser Pro Gly 
        755                 760 


<210> 38
<211> 724
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 38
Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser Glu Ala 
1               5                   10                  15      


Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly Phe Lys 
        35                  40                  45              


Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu Glu Glu 
    50                  55                  60                  


Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr Phe Pro 
65                  70                  75                  80  


Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala Phe Trp 
                85                  90                  95      


Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala Met Gln 
            100                 105                 110         


Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro Glu Leu 
        115                 120                 125             


Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser Gly Gly 
    130                 135                 140                 


Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro Ser Ser 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser Ala Thr 
                165                 170                 175     


Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu Met Thr 
            180                 185                 190         


Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala Phe Leu 
        195                 200                 205             


Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr His Asp 
    210                 215                 220                 


Thr Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
225                 230                 235                 240 


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
465                 470                 475                 480 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Glu Pro Lys 
                485                 490                 495     


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
            500                 505                 510         


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        515                 520                 525             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    530                 535                 540                 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
545                 550                 555                 560 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                565                 570                 575     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            580                 585                 590         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        595                 600                 605             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    610                 615                 620                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
625                 630                 635                 640 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                645                 650                 655     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            660                 665                 670         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        675                 680                 685             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    690                 695                 700                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
705                 710                 715                 720 


Leu Ser Pro Gly 
                


<210> 39
<211> 725
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 39
Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu Ser Glu Ala 
1               5                   10                  15      


Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu Asn Ala Glu 
            20                  25                  30          


Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp Gly Phe Lys 
        35                  40                  45              


Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu Glu Glu Glu 
    50                  55                  60                  


Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val Tyr Phe Pro 
65                  70                  75                  80  


Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu Ala Phe Trp 
                85                  90                  95      


Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro Ala Met Gln 
            100                 105                 110         


Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu Pro Glu Leu 
        115                 120                 125             


Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu Ser Gly Gly 
    130                 135                 140                 


Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu Pro Ser Ser 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala Ser Ala Thr 
                165                 170                 175     


Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu Glu Met Thr 
            180                 185                 190         


Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr Ala Phe Leu 
        195                 200                 205             


Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu Thr His Asp 
    210                 215                 220                 


Thr Lys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Asp Lys Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser 
        435                 440                 445             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    450                 455                 460                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
465                 470                 475                 480 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                485                 490                 495     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Ala Pro Glu 
            500                 505                 510         


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        515                 520                 525             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    530                 535                 540                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
545                 550                 555                 560 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                565                 570                 575     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            580                 585                 590         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        595                 600                 605             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    610                 615                 620                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
625                 630                 635                 640 


Gln Val Ser Leu Thr Cys Leu Val Asp Gly Phe Tyr Pro Ser Asp Ile 
                645                 650                 655     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            660                 665                 670         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        675                 680                 685             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    690                 695                 700                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
705                 710                 715                 720 


Ser Leu Ser Pro Gly 
                725 


<210> 40
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 40
Pro Leu Leu Arg Trp Val Leu Thr Leu Ser Phe Leu Val Ala Thr Val 
1               5                   10                  15      


Ala Val Gly Leu Tyr Ala Met 
            20              


<210> 41
<211> 508
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 41
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp 
            20                  25                  30          


Leu Ser Glu Ala Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala 
        35                  40                  45              


Glu Asn Ala Glu Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg 
    50                  55                  60                  


Asp Gly Phe Lys Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala 
65                  70                  75                  80  


Leu Glu Glu Glu Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro 
                85                  90                  95      


Val Tyr Phe Pro Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp 
            100                 105                 110         


Leu Ala Phe Trp Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr 
        115                 120                 125             


Pro Ala Met Gln Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr 
    130                 135                 140                 


Glu Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp 
145                 150                 155                 160 


Leu Ser Gly Gly Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp 
                165                 170                 175     


Leu Pro Ser Ser Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile 
            180                 185                 190         


Ala Ser Ala Thr Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser 
        195                 200                 205             


Leu Glu Met Thr Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys 
    210                 215                 220                 


Thr Ala Phe Leu Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu 
225                 230                 235                 240 


Leu Thr His Asp Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu 
                245                 250                 255     


Arg Gln Arg Ala Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr 
            260                 265                 270         


Pro Arg Gly Lys Pro Pro Leu Asn Thr Asp Lys Thr His Thr Cys Pro 
        275                 280                 285             


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
    290                 295                 300                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
305                 310                 315                 320 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                325                 330                 335     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            340                 345                 350         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        355                 360                 365             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    370                 375                 380                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
385                 390                 395                 400 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Val Tyr Pro Pro Ser Arg 
                405                 410                 415     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            420                 425                 430         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        435                 440                 445             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    450                 455                 460                 


Phe Ala Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
465                 470                 475                 480 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                485                 490                 495     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            500                 505             


<210> 42
<211> 247
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 42
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            20                  25                  30          


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        35                  40                  45              


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    50                  55                  60                  


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
65                  70                  75                  80  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                85                  90                  95      


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            100                 105                 110         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        115                 120                 125             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Val Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
145                 150                 155                 160 


Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Leu 
            180                 185                 190         


Thr Trp Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Lys 
                245         


<210> 43
<211> 506
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 43
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn 
145                 150                 155                 160 


Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln 
                245                 250                 255     


Asp Leu Ser Glu Ala Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln 
            260                 265                 270         


Ala Glu Asn Ala Glu Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr 
        275                 280                 285             


Arg Asp Gly Phe Lys Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val 
    290                 295                 300                 


Ala Leu Glu Glu Glu Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala 
305                 310                 315                 320 


Pro Val Tyr Phe Pro Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln 
                325                 330                 335     


Asp Leu Ala Phe Trp Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr 
            340                 345                 350         


Thr Pro Ala Met Gln Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg 
        355                 360                 365             


Thr Glu Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly 
    370                 375                 380                 


Asp Leu Ser Gly Gly Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu 
385                 390                 395                 400 


Asp Leu Pro Ser Ser Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn 
                405                 410                 415     


Ile Ala Ser Ala Thr Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn 
            420                 425                 430         


Ser Leu Glu Met Thr Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala 
        435                 440                 445             


Lys Thr Ala Phe Leu Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu 
    450                 455                 460                 


Leu Leu Thr His Asp Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly 
465                 470                 475                 480 


Leu Arg Gln Arg Ala Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu 
                485                 490                 495     


Thr Pro Arg Gly Lys Pro Pro Leu Asn Thr 
            500                 505     


<210> 44
<211> 245
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 44
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
145                 150                 155                 160 


Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly 
                245 


<210> 45
<211> 506
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 45
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
145                 150                 155                 160 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Asp Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Asp 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln 
                245                 250                 255     


Asp Leu Ser Glu Ala Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln 
            260                 265                 270         


Ala Glu Asn Ala Glu Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr 
        275                 280                 285             


Arg Asp Gly Phe Lys Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val 
    290                 295                 300                 


Ala Leu Glu Glu Glu Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala 
305                 310                 315                 320 


Pro Val Tyr Phe Pro Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln 
                325                 330                 335     


Asp Leu Ala Phe Trp Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr 
            340                 345                 350         


Thr Pro Ala Met Gln Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg 
        355                 360                 365             


Thr Glu Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly 
    370                 375                 380                 


Asp Leu Ser Gly Gly Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu 
385                 390                 395                 400 


Asp Leu Pro Ser Ser Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn 
                405                 410                 415     


Ile Ala Ser Ala Thr Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn 
            420                 425                 430         


Ser Leu Glu Met Thr Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala 
        435                 440                 445             


Lys Thr Ala Phe Leu Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu 
    450                 455                 460                 


Leu Leu Thr His Asp Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly 
465                 470                 475                 480 


Leu Arg Gln Arg Ala Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu 
                485                 490                 495     


Thr Pro Arg Gly Lys Pro Pro Leu Asn Thr 
            500                 505     


<210> 46
<211> 245
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 46
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Glu Leu Thr Lys Asn 
145                 150                 155                 160 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly 
                245 


<210> 47
<211> 506
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 47
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Glu Asn 
145                 150                 155                 160 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Trp 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln 
                245                 250                 255     


Asp Leu Ser Glu Ala Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln 
            260                 265                 270         


Ala Glu Asn Ala Glu Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr 
        275                 280                 285             


Arg Asp Gly Phe Lys Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val 
    290                 295                 300                 


Ala Leu Glu Glu Glu Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala 
305                 310                 315                 320 


Pro Val Tyr Phe Pro Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln 
                325                 330                 335     


Asp Leu Ala Phe Trp Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr 
            340                 345                 350         


Thr Pro Ala Met Gln Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg 
        355                 360                 365             


Thr Glu Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly 
    370                 375                 380                 


Asp Leu Ser Gly Gly Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu 
385                 390                 395                 400 


Asp Leu Pro Ser Ser Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn 
                405                 410                 415     


Ile Ala Ser Ala Thr Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn 
            420                 425                 430         


Ser Leu Glu Met Thr Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala 
        435                 440                 445             


Lys Thr Ala Phe Leu Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu 
    450                 455                 460                 


Leu Leu Thr His Asp Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly 
465                 470                 475                 480 


Leu Arg Gln Arg Ala Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu 
                485                 490                 495     


Thr Pro Arg Gly Lys Pro Pro Leu Asn Thr 
            500                 505     


<210> 48
<211> 245
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 48
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Arg Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn 
145                 150                 155                 160 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Val Ser Asp Gly Ser Phe Thr Leu Tyr Ser Lys 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly 
                245 


<210> 49
<211> 506
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 49
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu 
            20                  25                  30          


Ser Glu Ala Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu 
        35                  40                  45              


Asn Ala Glu Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp 
    50                  55                  60                  


Gly Phe Lys Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu 
65                  70                  75                  80  


Glu Glu Glu Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val 
                85                  90                  95      


Tyr Phe Pro Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu 
            100                 105                 110         


Ala Phe Trp Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro 
        115                 120                 125             


Ala Met Gln Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu 
    130                 135                 140                 


Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu 
145                 150                 155                 160 


Ser Gly Gly Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu 
                165                 170                 175     


Pro Ser Ser Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala 
            180                 185                 190         


Ser Ala Thr Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu 
        195                 200                 205             


Glu Met Thr Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr 
    210                 215                 220                 


Ala Phe Leu Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu 
225                 230                 235                 240 


Thr His Asp Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg 
                245                 250                 255     


Gln Arg Ala Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro 
            260                 265                 270         


Arg Gly Lys Pro Pro Leu Asn Thr Asp Lys Thr His Thr Cys Pro Pro 
        275                 280                 285             


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
    290                 295                 300                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
305                 310                 315                 320 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                325                 330                 335     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            340                 345                 350         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        355                 360                 365             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    370                 375                 380                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
385                 390                 395                 400 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
                405                 410                 415     


Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe 
            420                 425                 430         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        435                 440                 445             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    450                 455                 460                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
465                 470                 475                 480 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                485                 490                 495     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            500                 505     


<210> 50
<211> 245
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 50
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
145                 150                 155                 160 


Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly 
                245 


<210> 51
<211> 506
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 51
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu 
            20                  25                  30          


Ser Glu Ala Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu 
        35                  40                  45              


Asn Ala Glu Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp 
    50                  55                  60                  


Gly Phe Lys Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu 
65                  70                  75                  80  


Glu Glu Glu Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val 
                85                  90                  95      


Tyr Phe Pro Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu 
            100                 105                 110         


Ala Phe Trp Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro 
        115                 120                 125             


Ala Met Gln Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu 
    130                 135                 140                 


Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu 
145                 150                 155                 160 


Ser Gly Gly Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu 
                165                 170                 175     


Pro Ser Ser Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala 
            180                 185                 190         


Ser Ala Thr Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu 
        195                 200                 205             


Glu Met Thr Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr 
    210                 215                 220                 


Ala Phe Leu Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu 
225                 230                 235                 240 


Thr His Asp Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg 
                245                 250                 255     


Gln Arg Ala Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro 
            260                 265                 270         


Arg Gly Lys Pro Pro Leu Asn Thr Asp Lys Thr His Thr Cys Pro Pro 
        275                 280                 285             


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
    290                 295                 300                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
305                 310                 315                 320 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                325                 330                 335     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            340                 345                 350         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        355                 360                 365             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    370                 375                 380                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
385                 390                 395                 400 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
                405                 410                 415     


Glu Leu Thr Glu Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            420                 425                 430         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        435                 440                 445             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    450                 455                 460                 


Phe Leu Tyr Ser Trp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
465                 470                 475                 480 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                485                 490                 495     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            500                 505     


<210> 52
<211> 245
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 52
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Arg Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
145                 150                 155                 160 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Val Ser Asp Gly Ser Phe Thr Leu Tyr Ser Lys 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly 
                245 


<210> 53
<211> 472
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 53
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp 
            20                  25                  30          


Leu Ser Glu Ala Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala 
        35                  40                  45              


Glu Asn Ala Glu Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg 
    50                  55                  60                  


Asp Gly Phe Lys Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala 
65                  70                  75                  80  


Leu Glu Glu Glu Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro 
                85                  90                  95      


Val Tyr Phe Pro Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp 
            100                 105                 110         


Leu Ala Phe Trp Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr 
        115                 120                 125             


Pro Ala Met Gln Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr 
    130                 135                 140                 


Glu Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp 
145                 150                 155                 160 


Leu Ser Gly Gly Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp 
                165                 170                 175     


Leu Pro Ser Ser Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile 
            180                 185                 190         


Ala Ser Ala Thr Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser 
        195                 200                 205             


Leu Glu Met Thr Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys 
    210                 215                 220                 


Thr Ala Phe Leu Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu 
225                 230                 235                 240 


Leu Thr His Asp Thr Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Val Tyr Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Ala Leu 
            420                 425                 430         


Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470         


<210> 54
<211> 246
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 54
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            20                  25                  30          


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        35                  40                  45              


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    50                  55                  60                  


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
65                  70                  75                  80  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                85                  90                  95      


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            100                 105                 110         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        115                 120                 125             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Val Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
145                 150                 155                 160 


Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Leu 
            180                 185                 190         


Thr Trp Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly 
                245     


<210> 55
<211> 471
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 55
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
145                 150                 155                 160 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln 
                245                 250                 255     


Asp Leu Ser Glu Ala Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln 
            260                 265                 270         


Ala Glu Asn Ala Glu Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr 
        275                 280                 285             


Arg Asp Gly Phe Lys Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val 
    290                 295                 300                 


Ala Leu Glu Glu Glu Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala 
305                 310                 315                 320 


Pro Val Tyr Phe Pro Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln 
                325                 330                 335     


Asp Leu Ala Phe Trp Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr 
            340                 345                 350         


Thr Pro Ala Met Gln Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg 
        355                 360                 365             


Thr Glu Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly 
    370                 375                 380                 


Asp Leu Ser Gly Gly Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu 
385                 390                 395                 400 


Asp Leu Pro Ser Ser Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn 
                405                 410                 415     


Ile Ala Ser Ala Thr Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn 
            420                 425                 430         


Ser Leu Glu Met Thr Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala 
        435                 440                 445             


Lys Thr Ala Phe Leu Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu 
    450                 455                 460                 


Leu Leu Thr His Asp Thr Lys 
465                 470     


<210> 56
<211> 471
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 56
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu 
            20                  25                  30          


Ser Glu Ala Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu 
        35                  40                  45              


Asn Ala Glu Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp 
    50                  55                  60                  


Gly Phe Lys Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu 
65                  70                  75                  80  


Glu Glu Glu Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val 
                85                  90                  95      


Tyr Phe Pro Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu 
            100                 105                 110         


Ala Phe Trp Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro 
        115                 120                 125             


Ala Met Gln Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu 
    130                 135                 140                 


Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu 
145                 150                 155                 160 


Ser Gly Gly Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu 
                165                 170                 175     


Pro Ser Ser Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala 
            180                 185                 190         


Ser Ala Thr Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu 
        195                 200                 205             


Glu Met Thr Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr 
    210                 215                 220                 


Ala Phe Leu Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu 
225                 230                 235                 240 


Thr His Asp Thr Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly 
465                 470     


<210> 57
<211> 778
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 57
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu 
            20                  25                  30          


Ser Glu Ala Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu 
        35                  40                  45              


Asn Ala Glu Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp 
    50                  55                  60                  


Gly Phe Lys Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu 
65                  70                  75                  80  


Glu Glu Glu Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val 
                85                  90                  95      


Tyr Phe Pro Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu 
            100                 105                 110         


Ala Phe Trp Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro 
        115                 120                 125             


Ala Met Gln Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu 
    130                 135                 140                 


Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu 
145                 150                 155                 160 


Ser Gly Gly Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu 
                165                 170                 175     


Pro Ser Ser Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala 
            180                 185                 190         


Ser Ala Thr Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu 
        195                 200                 205             


Glu Met Thr Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr 
    210                 215                 220                 


Ala Phe Leu Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu 
225                 230                 235                 240 


Thr His Asp Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg 
                245                 250                 255     


Gln Arg Ala Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro 
            260                 265                 270         


Arg Gly Lys Pro Pro Leu Asn Thr Asp Lys Thr His Thr Cys Pro Pro 
        275                 280                 285             


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
    290                 295                 300                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
305                 310                 315                 320 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                325                 330                 335     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            340                 345                 350         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        355                 360                 365             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    370                 375                 380                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
385                 390                 395                 400 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
                405                 410                 415     


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            420                 425                 430         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        435                 440                 445             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    450                 455                 460                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
465                 470                 475                 480 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                485                 490                 495     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly 
            500                 505                 510         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    530                 535                 540                 


Gly Ser Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
545                 550                 555                 560 


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
                565                 570                 575     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            580                 585                 590         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        595                 600                 605             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    610                 615                 620                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
625                 630                 635                 640 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                645                 650                 655     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            660                 665                 670         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        675                 680                 685             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    690                 695                 700                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
705                 710                 715                 720 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                725                 730                 735     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            740                 745                 750         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        755                 760                 765             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    770                 775             


<210> 58
<211> 779
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 58
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu 
            20                  25                  30          


Ser Glu Ala Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu 
        35                  40                  45              


Asn Ala Glu Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp 
    50                  55                  60                  


Gly Phe Lys Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu 
65                  70                  75                  80  


Glu Glu Glu Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val 
                85                  90                  95      


Tyr Phe Pro Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu 
            100                 105                 110         


Ala Phe Trp Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro 
        115                 120                 125             


Ala Met Gln Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu 
    130                 135                 140                 


Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu 
145                 150                 155                 160 


Ser Gly Gly Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu 
                165                 170                 175     


Pro Ser Ser Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala 
            180                 185                 190         


Ser Ala Thr Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu 
        195                 200                 205             


Glu Met Thr Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr 
    210                 215                 220                 


Ala Phe Leu Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu 
225                 230                 235                 240 


Thr His Asp Thr Lys Asp Gln Ser Pro Ser Arg Ala Pro Gly Leu Arg 
                245                 250                 255     


Gln Arg Ala Ser Asn Lys Val Gln Asp Ser Ala Pro Val Glu Thr Pro 
            260                 265                 270         


Arg Gly Lys Pro Pro Leu Asn Thr Pro Ala Pro Glu Ala Ala Gly Gly 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Asp Lys Leu Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        515                 520                 525             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    530                 535                 540                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
545                 550                 555                 560 


Gly Ser Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
                565                 570                 575     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            580                 585                 590         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        595                 600                 605             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    610                 615                 620                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
625                 630                 635                 640 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                645                 650                 655     


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            660                 665                 670         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        675                 680                 685             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Asp Gly 
    690                 695                 700                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
705                 710                 715                 720 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                725                 730                 735     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            740                 745                 750         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        755                 760                 765             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    770                 775                 


<210> 59
<211> 743
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 59
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu 
            20                  25                  30          


Ser Glu Ala Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu 
        35                  40                  45              


Asn Ala Glu Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp 
    50                  55                  60                  


Gly Phe Lys Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu 
65                  70                  75                  80  


Glu Glu Glu Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val 
                85                  90                  95      


Tyr Phe Pro Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu 
            100                 105                 110         


Ala Phe Trp Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro 
        115                 120                 125             


Ala Met Gln Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu 
    130                 135                 140                 


Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu 
145                 150                 155                 160 


Ser Gly Gly Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu 
                165                 170                 175     


Pro Ser Ser Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala 
            180                 185                 190         


Ser Ala Thr Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu 
        195                 200                 205             


Glu Met Thr Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr 
    210                 215                 220                 


Ala Phe Leu Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu 
225                 230                 235                 240 


Thr His Asp Thr Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            500                 505                 510         


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        515                 520                 525             


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    530                 535                 540                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
545                 550                 555                 560 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                565                 570                 575     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            580                 585                 590         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        595                 600                 605             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    610                 615                 620                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
625                 630                 635                 640 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
                645                 650                 655     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            660                 665                 670         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        675                 680                 685             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    690                 695                 700                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
705                 710                 715                 720 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                725                 730                 735     


Ser Leu Ser Leu Ser Pro Gly 
            740             


<210> 60
<211> 744
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 60
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Met Glu Arg Pro Gln Pro Asp Ser Met Pro Gln Asp Leu 
            20                  25                  30          


Ser Glu Ala Leu Lys Glu Ala Thr Lys Glu Val His Thr Gln Ala Glu 
        35                  40                  45              


Asn Ala Glu Phe Met Arg Asn Phe Gln Lys Gly Gln Val Thr Arg Asp 
    50                  55                  60                  


Gly Phe Lys Leu Val Met Ala Ser Leu Tyr His Ile Tyr Val Ala Leu 
65                  70                  75                  80  


Glu Glu Glu Ile Glu Arg Asn Lys Glu Ser Pro Val Phe Ala Pro Val 
                85                  90                  95      


Tyr Phe Pro Glu Glu Leu His Arg Lys Ala Ala Leu Glu Gln Asp Leu 
            100                 105                 110         


Ala Phe Trp Tyr Gly Pro Arg Trp Gln Glu Val Ile Pro Tyr Thr Pro 
        115                 120                 125             


Ala Met Gln Arg Tyr Val Lys Arg Leu His Glu Val Gly Arg Thr Glu 
    130                 135                 140                 


Pro Glu Leu Leu Val Ala His Ala Tyr Thr Arg Tyr Leu Gly Asp Leu 
145                 150                 155                 160 


Ser Gly Gly Gln Val Leu Lys Lys Ile Ala Gln Lys Ala Leu Asp Leu 
                165                 170                 175     


Pro Ser Ser Gly Glu Gly Leu Ala Phe Phe Thr Phe Pro Asn Ile Ala 
            180                 185                 190         


Ser Ala Thr Lys Phe Lys Gln Leu Tyr Arg Ser Arg Met Asn Ser Leu 
        195                 200                 205             


Glu Met Thr Pro Ala Val Arg Gln Arg Val Ile Glu Glu Ala Lys Thr 
    210                 215                 220                 


Ala Phe Leu Leu Asn Ile Gln Leu Phe Glu Glu Leu Gln Glu Leu Leu 
225                 230                 235                 240 


Thr His Asp Thr Lys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Asp Lys Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
465                 470                 475                 480 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                485                 490                 495     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro 
        515                 520                 525             


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    530                 535                 540                 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
545                 550                 555                 560 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                565                 570                 575     


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            580                 585                 590         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        595                 600                 605             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    610                 615                 620                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
625                 630                 635                 640 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
                645                 650                 655     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Asp Gly Phe Tyr Pro 
            660                 665                 670         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        675                 680                 685             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    690                 695                 700                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
705                 710                 715                 720 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                725                 730                 735     


Lys Ser Leu Ser Leu Ser Pro Gly 
            740                 


<210> 61
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (1)..(25) 
<223> /note="This sequence may encompass 1-5 'Gly Gly Gly Gly Ser'
      repeating units"

<400> 61
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 62
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 62
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 63
<211> 40
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 63
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40  


<210> 64
<211> 65
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 64
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser 
65  


<210> 65
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 65
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


