                         SEQUENCE LISTING

<110>  NantKwest
 
<120>  ANTI-B7-H4 CHIMERIC ANTIGEN RECEPTOR-MODIFIED NK-92 CELLS

<130>  104077.0012PCT

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  405
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-B7-H4 CAR

<400>  1

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Ala Gln Pro Ala Glu Val Gln Leu Val Glu Ser Gly Gly 
            20                  25                  30          


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        35                  40                  45              


Gly Phe Thr Phe Asn Ser Tyr Ala Met His Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Asn Gly Gly Ser 
65                  70                  75                  80  


Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Phe Arg Lys Val His 
        115                 120                 125             


Gly Phe Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
                165                 170                 175     


Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser 
            180                 185                 190         


Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        195                 200                 205             


Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu 
225                 230                 235                 240 


Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Asp Ala Thr Phe 
                245                 250                 255     


Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ala Ala Ala 
            260                 265                 270         


Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu 
        275                 280                 285             


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    290                 295                 300                 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
305                 310                 315                 320 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                325                 330                 335     


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
            340                 345                 350         


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Leu Lys Ile Gln 
        355                 360                 365             


Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val Tyr 
    370                 375                 380                 


Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys His 
385                 390                 395                 400 


Glu Lys Pro Pro Gln 
                405 


<210>  2
<211>  1215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-B7-H4 CAR (nucleic acid sequence)

<400>  2
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg aagttcagct tgtagaatct ggaggtggat tggttcaacc tggtggctct      120

cttcgcctga gttgtgcagc ctctggtttt actttcaata gttacgctat gcattgggtt      180

cgtcaggctc ctgggaaagg cctggaatgg gtttcagcta ttagtggtaa tggaggtagt      240

actcgttacg cagacagtgt gaaaggtcgc ttcaccatca gccgtgataa ttctaagaac      300

actttgtacc tgcaaatgaa ctccttgcgc gcagaagaca cggctgtgta ctattgtgcc      360

cgtgatcgct ttcggaaggt tcatggtttc gatgtatggg gacaaggtac cctggtaacg      420

gtttctagcg gaggtggtgg gagtggtgga ggcggctcgg gtggaggtgg ttcaggagga      480

ggcggagata tccaaatgac tcaatctcct agttcactgt cagcctctgt tggtgatcgc      540

gtgaccatta cctgccaagc tagccaggat attagcaact acttgaactg gtatcagcag      600

aagcctggca aagccccaaa gctgttgatc tacgatgcaa gtaacttgga aactggcgtc      660

ccaagccgct tctctggatc tggttcaggc accgacttca ctttcactat cagcagcctg      720

cagcctgaag atatcgcaac ctactattgc cagcaggatg ctacttttcc tttgactttc      780

ggccaaggca ccaaggtgga gatcaaggcg gccgcgctga gcaacagcat catgtacttc      840

agccacttcg tgcctgtgtt cctgcctgcc aagcctacaa caacaccagc ccctagacct      900

ccaacccctg cccctacaat tgcctctcag cctctgtctc tgaggcccga agcttgtaga      960

cctgctgctg gcggagctgt gcacaccaga ggactggatt tcgcctgctt ttgggtgctg     1020

gtggtcgtgg gcggagtgct ggcttgttat tctctgctgg tcaccgtggc cttcatcatc     1080

ttttgggtcc gactgaagat ccaggtccga aaggccgcca tcaccagcta cgagaagtct     1140

gatggcgtgt acaccggcct gagcaccaga aaccaggaaa cctacgagac actgaagcac     1200

gagaagcccc cccag                                                      1215


<210>  3
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  3

Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser 
1               5                   10                  15      


Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu 
            20                  25                  30          


Thr Leu Lys His Glu Lys Pro Pro Gln 
        35                  40      


<210>  4
<211>  123
<212>  DNA
<213>  Homo sapiens

<400>  4
ctgaagatcc aggtccgaaa ggccgccatc accagctacg agaagtctga tggcgtgtac       60

accggcctga gcaccagaaa ccaggaaacc tacgagacac tgaagcacga gaagcccccc      120

cag                                                                    123


<210>  5
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  5

Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu 
1               5                   10                  15      


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            20                  25                  30          


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        35                  40                  45              


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    50                  55                  60                  


<210>  6
<211>  195
<212>  DNA
<213>  Homo sapiens

<400>  6
gcgctgagca acagcatcat gtacttcagc cacttcgtgc ctgtgttcct gcctgccaag       60

cctacaacaa caccagcccc tagacctcca acccctgccc ctacaattgc ctctcagcct      120

ctgtctctga ggcccgaagc ttgtagacct gctgctggcg gagctgtgca caccagagga      180

ctggatttcg cctgc                                                       195


<210>  7
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  7

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
            20                  25              


<210>  8
<211>  84
<212>  DNA
<213>  Homo sapiens

<400>  8
ttttgggtgc tggtggtcgt gggcggagtg ctggcttgtt attctctgct ggtcaccgtg       60

gccttcatca tcttttgggt ccga                                              84


<210>  9
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8-CD28-FceRIgamma

<400>  9

Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe Leu 
1               5                   10                  15      


Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
            20                  25                  30          


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
        35                  40                  45              


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
    50                  55                  60                  


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
65                  70                  75                  80  


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Leu Lys Ile Gln 
                85                  90                  95      


Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val Tyr 
            100                 105                 110         


Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys His 
        115                 120                 125             


Glu Lys Pro Pro Gln 
    130             


<210>  10
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8-CD28-FceRIgamma (nucleic acid sequence)

<400>  10
ctgagcaaca gcatcatgta cttcagccac ttcgtgcctg tgttcctgcc tgccaagcct       60

acaacaacac cagcccctag acctccaacc cctgccccta caattgcctc tcagcctctg      120

tctctgaggc ccgaagcttg tagacctgct gctggcggag ctgtgcacac cagaggactg      180

gatttcgcct gcttttgggt gctggtggtc gtgggcggag tgctggcttg ttattctctg      240

ctggtcaccg tggccttcat catcttttgg gtccgactga agatccaggt ccgaaaggcc      300

gccatcacca gctacgagaa gtctgatggc gtgtacaccg gcctgagcac cagaaaccag      360

gaaacctacg agacactgaa gcacgagaag cccccccag                             399


<210>  11
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Phe 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210>  12
<211>  765
<212>  DNA
<213>  Homo sapiens

<400>  12
atgtggcagc tgctcctccc aactgctctg ctacttctag tttcagctgg catgcggact       60

gaagatctcc caaaggctgt ggtgttcctg gagcctcaat ggtacagggt gctcgagaag      120

gacagtgtga ctctgaagtg ccagggagcc tactcccctg aggacaattc cacacagtgg      180

tttcacaatg agagcctcat ctcaagccag gcctcgagct acttcattga cgctgccaca      240

gtcgacgaca gtggagagta caggtgccag acaaacctct ccaccctcag tgacccggtg      300

cagctagaag tccatatcgg ctggctgttg ctccaggccc ctcggtgggt gttcaaggag      360

gaagacccta ttcacctgag gtgtcacagc tggaagaaca ctgctctgca taaggtcaca      420

tatttacaga atggcaaagg caggaagtat tttcatcata attctgactt ctacattcca      480

aaagccacac tcaaagacag cggctcctac ttctgcaggg ggctttttgg gagtaaaaat      540

gtgtcttcag agactgtgaa catcaccatc actcaaggtt tggcagtgtc aaccatctca      600

tcattctttc cacctgggta ccaagtctct ttctgcttgg tgatggtact cctttttgca      660

gtggacacag gactatattt ctctgtgaag acaaacattc gaagctcaac aagagactgg      720

aaggaccata aatttaaatg gagaaaggac cctcaagaca aatga                      765


<210>  13
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  13

Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro Gln Trp 
1               5                   10                  15      


Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln Gly Ala 
            20                  25                  30          


Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu Ser Leu 
        35                  40                  45              


Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr Val Asp 
    50                  55                  60                  


Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu Ser Asp 
65                  70                  75                  80  


Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln Ala Pro 
                85                  90                  95      


Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys His Ser 
            100                 105                 110         


Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn Gly Lys 
        115                 120                 125             


Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro Lys Ala 
    130                 135                 140                 


Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val Gly Ser 
145                 150                 155                 160 


Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln Gly Leu 
                165                 170                 175     


Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln Val Ser 
            180                 185                 190         


Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr 
        195                 200                 205             


Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp Lys Asp 
    210                 215                 220                 


His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
225                 230                 235     


<210>  14
<211>  765
<212>  DNA
<213>  Homo sapiens

<400>  14
atgtggcagc tgctgctgcc tacagctctc ctgctgctgg tgtccgccgg catgagaacc       60

gaggatctgc ctaaggccgt ggtgttcctg gaaccccagt ggtacagagt gctggaaaag      120

gacagcgtga ccctgaagtg ccagggcgcc tacagccccg aggacaatag cacccagtgg      180

ttccacaacg agagcctgat cagcagccag gccagcagct acttcatcga cgccgccacc      240

gtggacgaca gcggcgagta tagatgccag accaacctga gcaccctgag cgaccccgtg      300

cagctggaag tgcacatcgg atggctgctg ctgcaggccc ccagatgggt gttcaaagaa      360

gaggacccca tccacctgag atgccactct tggaagaaca ccgccctgca caaagtgacc      420

tacctgcaga acggcaaggg cagaaagtac ttccaccaca acagcgactt ctacatcccc      480

aaggccaccc tgaaggactc cggctcctac ttctgcagag gcctcgtggg cagcaagaac      540

gtgtccagcg agacagtgaa catcaccatc acccagggcc tggccgtgtc taccatcagc      600

agctttttcc cacccggcta ccaggtgtcc ttctgcctcg tgatggtgct gctgttcgcc      660

gtggacaccg gcctgtactt cagcgtgaaa acaaacatca gaagcagcac ccgggactgg      720

aaggaccaca agttcaagtg gcggaaggac ccccaggaca agtga                      765


<210>  15
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  15

Leu Lys Ile Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser 
1               5                   10                  15      


Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu 
            20                  25                  30          


Thr Leu Lys His Glu Lys Pro Pro Gln 
        35                  40      


<210>  16
<211>  123
<212>  DNA
<213>  Homo sapiens

<400>  16
ctgaagatcc aggtccgaaa ggccgccatc accagctacg agaagtctga tggcgtgtac       60

accggcctga gcaccagaaa ccaggaaacc tacgagacac tgaagcacga gaagcccccc      120

cag                                                                    123


<210>  17
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  17

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  18
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  18
gtgaagttca gcaggagcgc agacgccccc gcgtaccagc agggccagaa ccagctctat       60

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg      120

gaccctgaga tggggggaaa gccgcagaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgctaa                             339


<210>  19
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  19

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
            20                  25              


<210>  20
<211>  84
<212>  DNA
<213>  Homo sapiens

<400>  20
ttttgggtgc tggtggtcgt gggcggagtg ctggcttgtt attctctgct ggtcaccgtg       60

gccttcatca tcttttgggt ccga                                              84


<210>  21
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-B7-H4 scFv portion

<400>  21

Ala Gln Pro Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
1               5                   10                  15      


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
            20                  25                  30          


Phe Asn Ser Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
        35                  40                  45              


Leu Glu Trp Val Ser Ala Ile Ser Gly Asn Gly Gly Ser Thr Arg Tyr 
    50                  55                  60                  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
65                  70                  75                  80  


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Ala Arg Asp Arg Phe Arg Lys Val His Gly Phe Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Asp 
    130                 135                 140                 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
145                 150                 155                 160 


Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu 
                165                 170                 175     


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
    210                 215                 220                 


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Asp Ala Thr Phe Pro Leu Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
                245                 250 


<210>  22
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-B7-H4 scFv portion

<400>  22
gaagttcagc ttgtagaatc tggaggtgga ttggttcaac ctggtggctc tcttcgcctg       60

agttgtgcag cctctggttt tactttcaat agttacgcta tgcattgggt tcgtcaggct      120

cctgggaaag gcctggaatg ggtttcagct attagtggta atggaggtag tactcgttac      180

gcagacagtg tgaaaggtcg cttcaccatc agccgtgata attctaagaa cactttgtac      240

ctgcaaatga actccttgcg cgcagaagac acggctgtgt actattgtgc ccgtgatcgc      300

tttcggaagg ttcatggttt cgatgtatgg ggacaaggta ccctggtaac ggtttctagc      360

ggaggtggtg ggagtggtgg aggcggctcg ggtggaggtg gttcaggagg aggcggagat      420

atccaaatga ctcaatctcc tagttcactg tcagcctctg ttggtgatcg cgtgaccatt      480

acctgccaag ctagccagga tattagcaac tacttgaact ggtatcagca gaagcctggc      540

aaagccccaa agctgttgat ctacgatgca agtaacttgg aaactggcgt cccaagccgc      600

ttctctggat ctggttcagg caccgacttc actttcacta tcagcagcct gcagcctgaa      660

gatatcgcaa cctactattg ccagcaggat gctacttttc ctttgacttt cggccaaggc      720

accaaggtgg agatcaag                                                    738


<210>  23
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  24
<211>  459
<212>  DNA
<213>  Homo sapiens

<400>  24
atgtaccgga tgcagctgct gagctgtatc gccctgtctc tggccctcgt gaccaacagc       60

gcccctacca gcagcagcac caagaaaacc cagctgcagc tggaacatct gctgctggac      120

ctgcagatga tcctgaacgg catcaacaac tacaagaacc ccaagctgac ccggatgctg      180

accttcaagt tctacatgcc caagaaggcc accgaactga aacatctgca gtgcctggaa      240

gaggaactga agcccctgga agaagtgctg aacctggccc agagcaagaa cttccacctg      300

aggcccaggg acctgatcag caacatcaac gtgatcgtgc tggaactgaa aggcagcgag      360

acaaccttca tgtgcgagta cgccgacgag acagctacca tcgtggaatt tctgaaccgg      420

tggatcacct tctgccagag catcatcagc accctgacc                             459


<210>  25
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  erIL-2

<400>  25

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Ser Glu Lys Asp Glu Leu 
145                 150                 155                 160 


<210>  26
<211>  480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  erIL-2 (nucleic acid sequence)

<400>  26
atgtaccgga tgcagctgct gagctgtatc gccctgtctc tggccctcgt gaccaacagc       60

gcccctacca gcagcagcac caagaaaacc cagctgcagc tggaacatct gctgctggac      120

ctgcagatga tcctgaacgg catcaacaac tacaagaacc ccaagctgac ccggatgctg      180

accttcaagt tctacatgcc caagaaggcc accgaactga aacatctgca gtgcctggaa      240

gaggaactga agcccctgga agaagtgctg aacctggccc agagcaagaa cttccacctg      300

aggcccaggg acctgatcag caacatcaac gtgatcgtgc tggaactgaa aggcagcgag      360

acaaccttca tgtgcgagta cgccgacgag acagctacca tcgtggaatt tctgaaccgg      420

tggatcacct tctgccagag catcatcagc accctgaccg gctccgagaa ggacgagctg      480


<210>  27
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  erIL-15

<400>  27

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser Gly Ser Glu Lys Asp Glu Leu 
                165                 


<210>  28
<211>  510
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  erIL-15 (nucleic acid sequence)

<400>  28
atgcgcatca gcaagcccca cctgcgcagc atcagcatcc agtgctacct gtgcctgctg       60

ctgaacagcc acttcctgac cgaggccggc atccacgtgt tcatcctggg ctgcttcagc      120

gccggcctgc ccaagaccga ggccaactgg gtgaacgtga tcagcgacct gaagaagatc      180

gaggacctga tccagagcat gcacatcgac gccaccctgt acaccgagag cgacgtgcac      240

cccagctgca aggtgaccgc catgaagtgc ttcctgctgg agctgcaggt gatcagcctg      300

gagagcggcg acgccagcat ccacgacacc gtggagaacc tgatcatcct ggccaacaac      360

agcctgagca gcaacggcaa cgtgaccgag agcggctgca aggagtgcga ggagctggag      420

gagaagaaca tcaaggagtt cctgcagagc ttcgtgcaca tcgtgcagat gttcatcaac      480

accagcggct ccgagaagga cgagctgtaa                                       510


<210>  29
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1st generation CAR with CD3 zeta signaling domain

<400>  29
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg atatccagat gacccagaca acaagcagcc tgagcgcctc tctgggcgat      120

agagtgacaa tcagctgcag agccagccag gacatcagca agtacctgaa ctggtatcag      180

cagaaacccg acggcaccgt gaagctgctg atctaccaca caagcagact gcacagcggc      240

gtgccaagca gattttctgg cagcggcagc ggcaccgatt acagcctgac catcagcaac      300

ctggaacagg aagatatcgc tacctacttc tgtcagcagg gcaacaccct gccttacacc      360

tttggcggcg gaacaaagct ggaactgaaa agaggcggcg gaggaagcgg aggcggagga      420

tctgggggcg gaggctctgg cggaggggga tctgaagtgc agctgcagca gtctggacct      480

ggactggtgg ctccttctca gtccctgtct gtgacctgta cagtgtctgg cgtgtccctg      540

cctgattacg gcgtgtcctg gatcagacag cctcccagaa aaggcctgga atggctggga      600

gtgatctggg gcagcgagac aacctactac aacagcgccc tgaagtcccg gctgaccatc      660

atcaaggaca acagcaagag ccaggtgttc ctgaagatga acagcctgca gaccgacgac      720

accgccatct actactgcgc caagcactac tactacggcg gcagctacgc catggattat      780

tggggccagg gcaccaccgt gacagtgtca tctgcggccg cgctgagcaa cagcatcatg      840

tacttcagcc acttcgtgcc tgtgttcctg cctgccaagc ctacaacaac accagcccct      900

agacctccaa cccctgcccc tacaattgcc tctcagcctc tgtctctgag gcccgaagct      960

tgtagacctg ctgctggcgg agctgtgcac accagaggac tggatttcgc ctgcttttgg     1020

gtgctggtgg tcgtgggcgg agtgctggct tgttattctc tgctggtcac cgtggccttc     1080

atcatctttt gggtccgagt gaagttcagc agatccgccg atgcccctgc ttaccagcag     1140

ggccagaatc agctgtacaa cgagctgaac ctgggcagac gggaagagta cgacgtgctg     1200

gataagagaa gaggcagaga tcccgagatg ggcggcaagc cccagagaag aaagaatccc     1260

caggaaggcc tgtataacga actgcagaaa gacaagatgg ccgaggccta cagcgagatc     1320

ggcatgaagg gcgagagaag aagaggcaag ggccacgatg gactgtacca gggactgagc     1380

acagccacca aggataccta cgatgccctg cacatgcagg ccctgcctcc aagataa        1437


<210>  30
<211>  1221
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1st generation CAR with a FceRIgamma signaling domain

<400>  30
atggactgga tctggcggat tctgtttctc gtgggagctg ccacaggcgc tcattctgct       60

cagcctgccg atatccagat gacccagaca acaagcagcc tgagcgcctc tctgggcgat      120

agagtgacaa tcagctgcag agccagccag gacatcagca agtacctgaa ctggtatcag      180

cagaaacccg acggcaccgt gaagctgctg atctaccaca caagcagact gcacagcggc      240

gtgccaagca gattttctgg cagcggcagc ggcaccgatt acagcctgac catcagcaac      300

ctggaacagg aagatatcgc tacctacttc tgtcagcagg gcaacaccct gccttacacc      360

tttggcggcg gaacaaagct ggaactgaaa agaggcggcg gaggaagcgg aggcggagga      420

tctgggggcg gaggctctgg cggaggggga tctgaagtgc agctgcagca gtctggacct      480

ggactggtgg ctccttctca gtccctgtct gtgacctgta cagtgtctgg cgtgtccctg      540

cctgattacg gcgtgtcctg gatcagacag cctcccagaa aaggcctgga atggctggga      600

gtgatctggg gcagcgagac aacctactac aacagcgccc tgaagtcccg gctgaccatc      660

atcaaggaca acagcaagag ccaggtgttc ctgaagatga acagcctgca gaccgacgac      720

accgccatct actactgcgc caagcactac tactacggcg gcagctacgc catggattat      780

tggggccagg gcaccaccgt gacagtgtca tctgcggccg cgctgagcaa cagcatcatg      840

tacttcagcc acttcgtgcc tgtgttcctg cctgccaagc ctacaacaac accagcccct      900

agacctccaa cccctgcccc tacaattgcc tctcagcctc tgtctctgag gcccgaagct      960

tgtagacctg ctgctggcgg agctgtgcac accagaggac tggatttcgc ctgcttttgg     1020

gtgctggtgg tcgtgggcgg agtgctggct tgttattctc tgctggtcac cgtggccttc     1080

atcatctttt gggtccgact gaagatccag gtccgaaagg ccgccatcac cagctacgag     1140

aagtctgatg gcgtgtacac cggcctgagc accagaaacc aggaaaccta cgagacactg     1200

aagcacgaga agccccccca g                                               1221


