
                         SEQUENCE LISTING

<110>  9636137 Canada Inc.
 
<120>  USES OF DAN FAMILY BMP ANTAGONISTS FOR INHIBITING OCULAR 
       NEOVASCULARIZATION AND TREATING OCULAR CONDITIONS

<130>  306836.00020

<150>  US 62/879,755
<151>  2019-07-29

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  546
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(546)

<400>  1
atg atg ctt cgg gtc ctg gtg ggg gct gtc ctc cct gcc atg cta ctg         48
Met Met Leu Arg Val Leu Val Gly Ala Val Leu Pro Ala Met Leu Leu           
1               5                   10                  15                

gct gcc cca cca ccc atc aac aag ctg gca ctg ttc cca gat aag agt         96
Ala Ala Pro Pro Pro Ile Asn Lys Leu Ala Leu Phe Pro Asp Lys Ser           
            20                  25                  30                    

gcc tgg tgc gaa gcc aag aac atc acc cag atc gtg ggc cac agc ggc        144
Ala Trp Cys Glu Ala Lys Asn Ile Thr Gln Ile Val Gly His Ser Gly           
        35                  40                  45                        

tgt gag gcc aag tcc atc cag aac agg gcg tgc cta gga cag tgc ttc        192
Cys Glu Ala Lys Ser Ile Gln Asn Arg Ala Cys Leu Gly Gln Cys Phe           
    50                  55                  60                            

agc tac agc gtc ccc aac acc ttc cca cag tcc aca gag tcc ctg gtt        240
Ser Tyr Ser Val Pro Asn Thr Phe Pro Gln Ser Thr Glu Ser Leu Val           
65                  70                  75                  80            

cac tgt gac tcc tgc atg cca gcc cag tcc atg tgg gag att gtg acg        288
His Cys Asp Ser Cys Met Pro Ala Gln Ser Met Trp Glu Ile Val Thr           
                85                  90                  95                

ctg gag tgc ccg ggc cac gag gag gtg ccc agg gtg gac aag ctg gtg        336
Leu Glu Cys Pro Gly His Glu Glu Val Pro Arg Val Asp Lys Leu Val           
            100                 105                 110                   

gag aag atc ctg cac tgt agc tgc cag gcc tgc ggc aag gag cct agt        384
Glu Lys Ile Leu His Cys Ser Cys Gln Ala Cys Gly Lys Glu Pro Ser           
        115                 120                 125                       

cac gag ggg ctg agc gtc tat gtg cag ggc gag gac ggg ccg gga tcc        432
His Glu Gly Leu Ser Val Tyr Val Gln Gly Glu Asp Gly Pro Gly Ser           
    130                 135                 140                           

cag ccc ggc acc cac cct cac ccc cat ccc cac ccc cat cct ggc ggg        480
Gln Pro Gly Thr His Pro His Pro His Pro His Pro His Pro Gly Gly           
145                 150                 155                 160           

cag acc cct gag ccc gag gac ccc cct ggg gcc ccc cac aca gag gaa        528
Gln Thr Pro Glu Pro Glu Asp Pro Pro Gly Ala Pro His Thr Glu Glu           
                165                 170                 175               

gag ggg gct gag gac tga                                                546
Glu Gly Ala Glu Asp                                                       
            180                                                           


<210>  2
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Met Leu Arg Val Leu Val Gly Ala Val Leu Pro Ala Met Leu Leu 
1               5                   10                  15      


Ala Ala Pro Pro Pro Ile Asn Lys Leu Ala Leu Phe Pro Asp Lys Ser 
            20                  25                  30          


Ala Trp Cys Glu Ala Lys Asn Ile Thr Gln Ile Val Gly His Ser Gly 
        35                  40                  45              


Cys Glu Ala Lys Ser Ile Gln Asn Arg Ala Cys Leu Gly Gln Cys Phe 
    50                  55                  60                  


Ser Tyr Ser Val Pro Asn Thr Phe Pro Gln Ser Thr Glu Ser Leu Val 
65                  70                  75                  80  


His Cys Asp Ser Cys Met Pro Ala Gln Ser Met Trp Glu Ile Val Thr 
                85                  90                  95      


Leu Glu Cys Pro Gly His Glu Glu Val Pro Arg Val Asp Lys Leu Val 
            100                 105                 110         


Glu Lys Ile Leu His Cys Ser Cys Gln Ala Cys Gly Lys Glu Pro Ser 
        115                 120                 125             


His Glu Gly Leu Ser Val Tyr Val Gln Gly Glu Asp Gly Pro Gly Ser 
    130                 135                 140                 


Gln Pro Gly Thr His Pro His Pro His Pro His Pro His Pro Gly Gly 
145                 150                 155                 160 


Gln Thr Pro Glu Pro Glu Asp Pro Pro Gly Ala Pro His Thr Glu Glu 
                165                 170                 175     


Glu Gly Ala Glu Asp 
            180     


<210>  3
<211>  432
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(432)

<400>  3
atg agc cgc aca gcc tac acg gtg gga gcc ctg ctt ctc ctc ttg ggg         48
Met Ser Arg Thr Ala Tyr Thr Val Gly Ala Leu Leu Leu Leu Leu Gly           
1               5                   10                  15                

acc ctg ctg ccg gct gct gaa ggg aaa aag aaa ggg tcc caa ggt gcc         96
Thr Leu Leu Pro Ala Ala Glu Gly Lys Lys Lys Gly Ser Gln Gly Ala           
            20                  25                  30                    

atc ccc ccg cca gac aag gcc ctg cat gtg acg gag cgc aaa tac ctg        144
Ile Pro Pro Pro Asp Lys Ala Leu His Val Thr Glu Arg Lys Tyr Leu           
        35                  40                  45                        

aag cga gac tgg tgc aaa acc cag ccg ctt aag cag acc atc cac gag        192
Lys Arg Asp Trp Cys Lys Thr Gln Pro Leu Lys Gln Thr Ile His Glu           
    50                  55                  60                            

gaa ggc tgc aac agt cgc acc atc atc aac cgc ttc tgt tac ggc cag        240
Glu Gly Cys Asn Ser Arg Thr Ile Ile Asn Arg Phe Cys Tyr Gly Gln           
65                  70                  75                  80            

tgc aac tct ttc tac atc ccc agg cac atc cgg aag gag gaa ggt tcc        288
Cys Asn Ser Phe Tyr Ile Pro Arg His Ile Arg Lys Glu Glu Gly Ser           
                85                  90                  95                

ttt cag tcc tgc tcc ttc tgc aag ccc aag aaa ttc act acc atg atg        336
Phe Gln Ser Cys Ser Phe Cys Lys Pro Lys Lys Phe Thr Thr Met Met           
            100                 105                 110                   

gtc aca ctc aac tgc cct gaa cta cag cca cct acc aag aag aag aga        384
Val Thr Leu Asn Cys Pro Glu Leu Gln Pro Pro Thr Lys Lys Lys Arg           
        115                 120                 125                       

gtc aca cgt gtg aag cag tgt cgt tgc ata tcc atc gat ttg gat taa        432
Val Thr Arg Val Lys Gln Cys Arg Cys Ile Ser Ile Asp Leu Asp               
    130                 135                 140                           


<210>  4
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Arg Thr Ala Tyr Thr Val Gly Ala Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Thr Leu Leu Pro Ala Ala Glu Gly Lys Lys Lys Gly Ser Gln Gly Ala 
            20                  25                  30          


Ile Pro Pro Pro Asp Lys Ala Leu His Val Thr Glu Arg Lys Tyr Leu 
        35                  40                  45              


Lys Arg Asp Trp Cys Lys Thr Gln Pro Leu Lys Gln Thr Ile His Glu 
    50                  55                  60                  


Glu Gly Cys Asn Ser Arg Thr Ile Ile Asn Arg Phe Cys Tyr Gly Gln 
65                  70                  75                  80  


Cys Asn Ser Phe Tyr Ile Pro Arg His Ile Arg Lys Glu Glu Gly Ser 
                85                  90                  95      


Phe Gln Ser Cys Ser Phe Cys Lys Pro Lys Lys Phe Thr Thr Met Met 
            100                 105                 110         


Val Thr Leu Asn Cys Pro Glu Leu Gln Pro Pro Thr Lys Lys Lys Arg 
        115                 120                 125             


Val Thr Arg Val Lys Gln Cys Arg Cys Ile Ser Ile Asp Leu Asp 
    130                 135                 140             


<210>  5
<211>  507
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(507)

<400>  5
atg ttc tgg aag ctt tcc ctg tcc ttg ttc ctg gtg gcg gtg ctg gtg         48
Met Phe Trp Lys Leu Ser Leu Ser Leu Phe Leu Val Ala Val Leu Val           
1               5                   10                  15                

aag gtg gcg gaa gcc cgg aag aac cgg ccg gcg ggc gcc atc ccc tcg         96
Lys Val Ala Glu Ala Arg Lys Asn Arg Pro Ala Gly Ala Ile Pro Ser           
            20                  25                  30                    

cct tac aag gac ggc agc agc aac aac tcg gag aga tgg cag cac cag        144
Pro Tyr Lys Asp Gly Ser Ser Asn Asn Ser Glu Arg Trp Gln His Gln           
        35                  40                  45                        

atc aag gag gtg ctg gcc tcc agc cag gag gcc ctg gtg gtc acc gag        192
Ile Lys Glu Val Leu Ala Ser Ser Gln Glu Ala Leu Val Val Thr Glu           
    50                  55                  60                            

cgc aag tac ctc aag agt gac tgg tgc aag acg cag ccg ctg cgg cag        240
Arg Lys Tyr Leu Lys Ser Asp Trp Cys Lys Thr Gln Pro Leu Arg Gln           
65                  70                  75                  80            

acg gtg agc gag gag ggc tgc cgg agc cgc acc atc ctc aac cgc ttc        288
Thr Val Ser Glu Glu Gly Cys Arg Ser Arg Thr Ile Leu Asn Arg Phe           
                85                  90                  95                

tgc tac ggc cag tgc aac tcc ttc tac atc ccg cgg cac gtg aag aag        336
Cys Tyr Gly Gln Cys Asn Ser Phe Tyr Ile Pro Arg His Val Lys Lys           
            100                 105                 110                   

gag gag gag tcc ttc cag tcc tgc gcc ttc tgc aag ccc cag cgc gtc        384
Glu Glu Glu Ser Phe Gln Ser Cys Ala Phe Cys Lys Pro Gln Arg Val           
        115                 120                 125                       

acc tcc gtc ctc gtg gag ctc gag tgc ccc ggc ctg gac cca ccc ttc        432
Thr Ser Val Leu Val Glu Leu Glu Cys Pro Gly Leu Asp Pro Pro Phe           
    130                 135                 140                           

cga ctc aag aaa atc cag aag gtg aag cag tgc cgg tgc atg tcc gtg        480
Arg Leu Lys Lys Ile Gln Lys Val Lys Gln Cys Arg Cys Met Ser Val           
145                 150                 155                 160           

aac ctg agc gac tcg gac aag cag tga                                    507
Asn Leu Ser Asp Ser Asp Lys Gln                                           
                165                                                       


<210>  6
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Phe Trp Lys Leu Ser Leu Ser Leu Phe Leu Val Ala Val Leu Val 
1               5                   10                  15      


Lys Val Ala Glu Ala Arg Lys Asn Arg Pro Ala Gly Ala Ile Pro Ser 
            20                  25                  30          


Pro Tyr Lys Asp Gly Ser Ser Asn Asn Ser Glu Arg Trp Gln His Gln 
        35                  40                  45              


Ile Lys Glu Val Leu Ala Ser Ser Gln Glu Ala Leu Val Val Thr Glu 
    50                  55                  60                  


Arg Lys Tyr Leu Lys Ser Asp Trp Cys Lys Thr Gln Pro Leu Arg Gln 
65                  70                  75                  80  


Thr Val Ser Glu Glu Gly Cys Arg Ser Arg Thr Ile Leu Asn Arg Phe 
                85                  90                  95      


Cys Tyr Gly Gln Cys Asn Ser Phe Tyr Ile Pro Arg His Val Lys Lys 
            100                 105                 110         


Glu Glu Glu Ser Phe Gln Ser Cys Ala Phe Cys Lys Pro Gln Arg Val 
        115                 120                 125             


Thr Ser Val Leu Val Glu Leu Glu Cys Pro Gly Leu Asp Pro Pro Phe 
    130                 135                 140                 


Arg Leu Lys Lys Ile Gln Lys Val Lys Gln Cys Arg Cys Met Ser Val 
145                 150                 155                 160 


Asn Leu Ser Asp Ser Asp Lys Gln 
                165             


<210>  7
<211>  804
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(804)

<400>  7
atg cat ctc ctc tta ttt cag ctg ctg gta ctc ctg cct cta gga aag         48
Met His Leu Leu Leu Phe Gln Leu Leu Val Leu Leu Pro Leu Gly Lys           
1               5                   10                  15                

acc aca cgg cac cag gat ggc cgc cag aat cag agt tct ctt tcc ccc         96
Thr Thr Arg His Gln Asp Gly Arg Gln Asn Gln Ser Ser Leu Ser Pro           
            20                  25                  30                    

gta ctc ctg cca agg aat caa aga gag ctt ccc aca ggc aac cat gag        144
Val Leu Leu Pro Arg Asn Gln Arg Glu Leu Pro Thr Gly Asn His Glu           
        35                  40                  45                        

gaa gct gag gag aag cca gat ctg ttt gtc gca gtg cca cac ctt gta        192
Glu Ala Glu Glu Lys Pro Asp Leu Phe Val Ala Val Pro His Leu Val           
    50                  55                  60                            

gcc acc agc cct gca ggg gaa ggc cag agg cag aga gag aag atg ctg        240
Ala Thr Ser Pro Ala Gly Glu Gly Gln Arg Gln Arg Glu Lys Met Leu           
65                  70                  75                  80            

tcc aga ttt ggc agg ttc tgg aag aag cct gag aga gaa atg cat cca        288
Ser Arg Phe Gly Arg Phe Trp Lys Lys Pro Glu Arg Glu Met His Pro           
                85                  90                  95                

tcc agg gac tca gat agt gag ccc ttc cca cct ggg acc cag tcc ctc        336
Ser Arg Asp Ser Asp Ser Glu Pro Phe Pro Pro Gly Thr Gln Ser Leu           
            100                 105                 110                   

atc cag ccg ata gat gga atg aaa atg gag aaa tct cct ctt cgg gaa        384
Ile Gln Pro Ile Asp Gly Met Lys Met Glu Lys Ser Pro Leu Arg Glu           
        115                 120                 125                       

gaa gcc aag aaa ttc tgg cac cac ttc atg ttc aga aaa act ccg gct        432
Glu Ala Lys Lys Phe Trp His His Phe Met Phe Arg Lys Thr Pro Ala           
    130                 135                 140                           

tct cag ggg gtc atc ttg ccc atc aaa agc cat gaa gta cat tgg gag        480
Ser Gln Gly Val Ile Leu Pro Ile Lys Ser His Glu Val His Trp Glu           
145                 150                 155                 160           

acc tgc agg aca gtg ccc ttc agc cag act ata acc cac gaa ggc tgt        528
Thr Cys Arg Thr Val Pro Phe Ser Gln Thr Ile Thr His Glu Gly Cys           
                165                 170                 175               

gaa aaa gta gtt gtt cag aac aac ctt tgc ttt ggg aaa tgc ggg tct        576
Glu Lys Val Val Val Gln Asn Asn Leu Cys Phe Gly Lys Cys Gly Ser           
            180                 185                 190                   

gtt cat ttt cct gga gcc gcg cag cac tcc cat acc tcc tgc tct cac        624
Val His Phe Pro Gly Ala Ala Gln His Ser His Thr Ser Cys Ser His           
        195                 200                 205                       

tgt ttg cct gcc aag ttc acc acg atg cac ttg cca ctg aac tgc act        672
Cys Leu Pro Ala Lys Phe Thr Thr Met His Leu Pro Leu Asn Cys Thr           
    210                 215                 220                           

gaa ctt tcc tcc gtg atc aag gtg gtg atg ctg gtg gag gag tgc cag        720
Glu Leu Ser Ser Val Ile Lys Val Val Met Leu Val Glu Glu Cys Gln           
225                 230                 235                 240           

tgc aag gtg aag acg gag cat gaa gat gga cac atc cta cat gct ggc        768
Cys Lys Val Lys Thr Glu His Glu Asp Gly His Ile Leu His Ala Gly           
                245                 250                 255               

tcc cag gat tcc ttt atc cca gga gtt tca gct tga                        804
Ser Gln Asp Ser Phe Ile Pro Gly Val Ser Ala                               
            260                 265                                       


<210>  8
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  8

Met His Leu Leu Leu Phe Gln Leu Leu Val Leu Leu Pro Leu Gly Lys 
1               5                   10                  15      


Thr Thr Arg His Gln Asp Gly Arg Gln Asn Gln Ser Ser Leu Ser Pro 
            20                  25                  30          


Val Leu Leu Pro Arg Asn Gln Arg Glu Leu Pro Thr Gly Asn His Glu 
        35                  40                  45              


Glu Ala Glu Glu Lys Pro Asp Leu Phe Val Ala Val Pro His Leu Val 
    50                  55                  60                  


Ala Thr Ser Pro Ala Gly Glu Gly Gln Arg Gln Arg Glu Lys Met Leu 
65                  70                  75                  80  


Ser Arg Phe Gly Arg Phe Trp Lys Lys Pro Glu Arg Glu Met His Pro 
                85                  90                  95      


Ser Arg Asp Ser Asp Ser Glu Pro Phe Pro Pro Gly Thr Gln Ser Leu 
            100                 105                 110         


Ile Gln Pro Ile Asp Gly Met Lys Met Glu Lys Ser Pro Leu Arg Glu 
        115                 120                 125             


Glu Ala Lys Lys Phe Trp His His Phe Met Phe Arg Lys Thr Pro Ala 
    130                 135                 140                 


Ser Gln Gly Val Ile Leu Pro Ile Lys Ser His Glu Val His Trp Glu 
145                 150                 155                 160 


Thr Cys Arg Thr Val Pro Phe Ser Gln Thr Ile Thr His Glu Gly Cys 
                165                 170                 175     


Glu Lys Val Val Val Gln Asn Asn Leu Cys Phe Gly Lys Cys Gly Ser 
            180                 185                 190         


Val His Phe Pro Gly Ala Ala Gln His Ser His Thr Ser Cys Ser His 
        195                 200                 205             


Cys Leu Pro Ala Lys Phe Thr Thr Met His Leu Pro Leu Asn Cys Thr 
    210                 215                 220                 


Glu Leu Ser Ser Val Ile Lys Val Val Met Leu Val Glu Glu Cys Gln 
225                 230                 235                 240 


Cys Lys Val Lys Thr Glu His Glu Asp Gly His Ile Leu His Ala Gly 
                245                 250                 255     


Ser Gln Asp Ser Phe Ile Pro Gly Val Ser Ala 
            260                 265         


<210>  9
<211>  570
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(570)

<400>  9
atg ctc ctt ggc cag cta tcc act ctt ctg tgc ctg ctt agc ggg gcc         48
Met Leu Leu Gly Gln Leu Ser Thr Leu Leu Cys Leu Leu Ser Gly Ala           
1               5                   10                  15                

ctg cct aca ggc tca ggg agg cct gaa ccc cag tct cct cga cct cag         96
Leu Pro Thr Gly Ser Gly Arg Pro Glu Pro Gln Ser Pro Arg Pro Gln           
            20                  25                  30                    

tcc tgg gct gca gcc aat cag acc tgg gct ctg ggc cca ggg gcc ctg        144
Ser Trp Ala Ala Ala Asn Gln Thr Trp Ala Leu Gly Pro Gly Ala Leu           
        35                  40                  45                        

ccc cca ctg gtg cca gct tct gcc ctt ggg agc tgg aag gcc ttc ttg        192
Pro Pro Leu Val Pro Ala Ser Ala Leu Gly Ser Trp Lys Ala Phe Leu           
    50                  55                  60                            

ggc ctg cag aaa gcc agg cag ctg ggg atg ggc agg ctg cag cgt ggg        240
Gly Leu Gln Lys Ala Arg Gln Leu Gly Met Gly Arg Leu Gln Arg Gly           
65                  70                  75                  80            

caa gac gag gtg gct gct gtg act ctg ccg ctg aac cct cag gaa gtg        288
Gln Asp Glu Val Ala Ala Val Thr Leu Pro Leu Asn Pro Gln Glu Val           
                85                  90                  95                

atc cag ggg atg tgt aag gct gtg ccc ttc gtt cag gtg ttc tcc cgg        336
Ile Gln Gly Met Cys Lys Ala Val Pro Phe Val Gln Val Phe Ser Arg           
            100                 105                 110                   

ccc ggc tgc tca gcc ata cgc ctc cga aat cat ctg tgc ttt ggt cat        384
Pro Gly Cys Ser Ala Ile Arg Leu Arg Asn His Leu Cys Phe Gly His           
        115                 120                 125                       

tgc tcc tct ctc tac atc cct ggc tcg gac ccc acc cca cta gtc ctg        432
Cys Ser Ser Leu Tyr Ile Pro Gly Ser Asp Pro Thr Pro Leu Val Leu           
    130                 135                 140                           

tgc aac agc tgt atg cct gct cgc aag cgt tgg gca ccc gtg gtc ctg        480
Cys Asn Ser Cys Met Pro Ala Arg Lys Arg Trp Ala Pro Val Val Leu           
145                 150                 155                 160           

tgg tgt ctc act ggc agc tca gcc tcc cgt cga cgg gtg aag ata tcc        528
Trp Cys Leu Thr Gly Ser Ser Ala Ser Arg Arg Arg Val Lys Ile Ser           
                165                 170                 175               

acc atg ctg atc gag ggg tgt cac tgc agc cca aaa gca tga                570
Thr Met Leu Ile Glu Gly Cys His Cys Ser Pro Lys Ala                       
            180                 185                                       


<210>  10
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Leu Gly Gln Leu Ser Thr Leu Leu Cys Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Pro Thr Gly Ser Gly Arg Pro Glu Pro Gln Ser Pro Arg Pro Gln 
            20                  25                  30          


Ser Trp Ala Ala Ala Asn Gln Thr Trp Ala Leu Gly Pro Gly Ala Leu 
        35                  40                  45              


Pro Pro Leu Val Pro Ala Ser Ala Leu Gly Ser Trp Lys Ala Phe Leu 
    50                  55                  60                  


Gly Leu Gln Lys Ala Arg Gln Leu Gly Met Gly Arg Leu Gln Arg Gly 
65                  70                  75                  80  


Gln Asp Glu Val Ala Ala Val Thr Leu Pro Leu Asn Pro Gln Glu Val 
                85                  90                  95      


Ile Gln Gly Met Cys Lys Ala Val Pro Phe Val Gln Val Phe Ser Arg 
            100                 105                 110         


Pro Gly Cys Ser Ala Ile Arg Leu Arg Asn His Leu Cys Phe Gly His 
        115                 120                 125             


Cys Ser Ser Leu Tyr Ile Pro Gly Ser Asp Pro Thr Pro Leu Val Leu 
    130                 135                 140                 


Cys Asn Ser Cys Met Pro Ala Arg Lys Arg Trp Ala Pro Val Val Leu 
145                 150                 155                 160 


Trp Cys Leu Thr Gly Ser Ser Ala Ser Arg Arg Arg Val Lys Ile Ser 
                165                 170                 175     


Thr Met Leu Ile Glu Gly Cys His Cys Ser Pro Lys Ala 
            180                 185                 


<210>  11
<211>  642
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(642)

<400>  11
atg cag ctc cca ctg gcc ctg tgt ctc gtc tgc ctg ctg gta cac aca         48
Met Gln Leu Pro Leu Ala Leu Cys Leu Val Cys Leu Leu Val His Thr           
1               5                   10                  15                

gcc ttc cgt gta gtg gag ggc cag ggg tgg cag gcg ttc aag aat gat         96
Ala Phe Arg Val Val Glu Gly Gln Gly Trp Gln Ala Phe Lys Asn Asp           
            20                  25                  30                    

gcc acg gaa atc atc ccc gag ctc gga gag tac ccc gag cct cca ccg        144
Ala Thr Glu Ile Ile Pro Glu Leu Gly Glu Tyr Pro Glu Pro Pro Pro           
        35                  40                  45                        

gag ctg gag aac aac aag acc atg aac cgg gcg gag aac gga ggg cgg        192
Glu Leu Glu Asn Asn Lys Thr Met Asn Arg Ala Glu Asn Gly Gly Arg           
    50                  55                  60                            

cct ccc cac cac ccc ttt gag acc aaa gac gtg tcc gag tac agc tgc        240
Pro Pro His His Pro Phe Glu Thr Lys Asp Val Ser Glu Tyr Ser Cys           
65                  70                  75                  80            

cgc gag ctg cac ttc acc cgc tac gtg acc gat ggg ccg tgc cgc agc        288
Arg Glu Leu His Phe Thr Arg Tyr Val Thr Asp Gly Pro Cys Arg Ser           
                85                  90                  95                

gcc aag ccg gtc acc gag ctg gtg tgc tcc ggc cag tgc ggc ccg gcg        336
Ala Lys Pro Val Thr Glu Leu Val Cys Ser Gly Gln Cys Gly Pro Ala           
            100                 105                 110                   

cgc ctg ctg ccc aac gcc atc ggc cgc ggc aag tgg tgg cga cct agt        384
Arg Leu Leu Pro Asn Ala Ile Gly Arg Gly Lys Trp Trp Arg Pro Ser           
        115                 120                 125                       

ggg ccc gac ttc cgc tgc atc ccc gac cgc tac cgc gcg cag cgc gtg        432
Gly Pro Asp Phe Arg Cys Ile Pro Asp Arg Tyr Arg Ala Gln Arg Val           
    130                 135                 140                           

cag ctg ctg tgt ccc ggt ggt gag gcg ccg cgc gcg cgc aag gtg cgc        480
Gln Leu Leu Cys Pro Gly Gly Glu Ala Pro Arg Ala Arg Lys Val Arg           
145                 150                 155                 160           

ctg gtg gcc tcg tgc aag tgc aag cgc ctc acc cgc ttc cac aac cag        528
Leu Val Ala Ser Cys Lys Cys Lys Arg Leu Thr Arg Phe His Asn Gln           
                165                 170                 175               

tcg gag ctc aag gac ttc ggg acc gag gcc gct cgg ccg cag aag ggc        576
Ser Glu Leu Lys Asp Phe Gly Thr Glu Ala Ala Arg Pro Gln Lys Gly           
            180                 185                 190                   

cgg aag ccg cgg ccc cgc gcc cgg agc gcc aaa gcc aac cag gcc gag        624
Arg Lys Pro Arg Pro Arg Ala Arg Ser Ala Lys Ala Asn Gln Ala Glu           
        195                 200                 205                       

ctg gag aac gcc tac tag                                                642
Leu Glu Asn Ala Tyr                                                       
    210                                                                   


<210>  12
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gln Leu Pro Leu Ala Leu Cys Leu Val Cys Leu Leu Val His Thr 
1               5                   10                  15      


Ala Phe Arg Val Val Glu Gly Gln Gly Trp Gln Ala Phe Lys Asn Asp 
            20                  25                  30          


Ala Thr Glu Ile Ile Pro Glu Leu Gly Glu Tyr Pro Glu Pro Pro Pro 
        35                  40                  45              


Glu Leu Glu Asn Asn Lys Thr Met Asn Arg Ala Glu Asn Gly Gly Arg 
    50                  55                  60                  


Pro Pro His His Pro Phe Glu Thr Lys Asp Val Ser Glu Tyr Ser Cys 
65                  70                  75                  80  


Arg Glu Leu His Phe Thr Arg Tyr Val Thr Asp Gly Pro Cys Arg Ser 
                85                  90                  95      


Ala Lys Pro Val Thr Glu Leu Val Cys Ser Gly Gln Cys Gly Pro Ala 
            100                 105                 110         


Arg Leu Leu Pro Asn Ala Ile Gly Arg Gly Lys Trp Trp Arg Pro Ser 
        115                 120                 125             


Gly Pro Asp Phe Arg Cys Ile Pro Asp Arg Tyr Arg Ala Gln Arg Val 
    130                 135                 140                 


Gln Leu Leu Cys Pro Gly Gly Glu Ala Pro Arg Ala Arg Lys Val Arg 
145                 150                 155                 160 


Leu Val Ala Ser Cys Lys Cys Lys Arg Leu Thr Arg Phe His Asn Gln 
                165                 170                 175     


Ser Glu Leu Lys Asp Phe Gly Thr Glu Ala Ala Arg Pro Gln Lys Gly 
            180                 185                 190         


Arg Lys Pro Arg Pro Arg Ala Arg Ser Ala Lys Ala Asn Gln Ala Glu 
        195                 200                 205             


Leu Glu Asn Ala Tyr 
    210             


<210>  13
<211>  621
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(621)

<400>  13
atg ctt cct cct gcc att cat ttc tat ctc ctt ccc ctt gca tgc atc         48
Met Leu Pro Pro Ala Ile His Phe Tyr Leu Leu Pro Leu Ala Cys Ile           
1               5                   10                  15                

cta atg aaa agc tgt ttg gct ttt aaa aat gat gcc aca gaa atc ctt         96
Leu Met Lys Ser Cys Leu Ala Phe Lys Asn Asp Ala Thr Glu Ile Leu           
            20                  25                  30                    

tat tca cat gtg gtt aaa cct gtt cca gca cac ccc agc agc aac agc        144
Tyr Ser His Val Val Lys Pro Val Pro Ala His Pro Ser Ser Asn Ser           
        35                  40                  45                        

acg ttg aat caa gcc aga aat gga ggc agg cat ttc agt aac act gga        192
Thr Leu Asn Gln Ala Arg Asn Gly Gly Arg His Phe Ser Asn Thr Gly           
    50                  55                  60                            

ctg gat cgg aac act cgg gtt caa gtg ggt tgc cgg gaa ctg cgt tcc        240
Leu Asp Arg Asn Thr Arg Val Gln Val Gly Cys Arg Glu Leu Arg Ser           
65                  70                  75                  80            

acc aaa tac atc tct gat ggc cag tgc acc agc atc agc cct ctg aag        288
Thr Lys Tyr Ile Ser Asp Gly Gln Cys Thr Ser Ile Ser Pro Leu Lys           
                85                  90                  95                

gag ctg gtg tgt gct ggc gag tgc ttg ccc ctg cca gtg ctc cct aac        336
Glu Leu Val Cys Ala Gly Glu Cys Leu Pro Leu Pro Val Leu Pro Asn           
            100                 105                 110                   

tgg att gga gga ggc tat gga aca aag tac tgg agc agg agg agc tcc        384
Trp Ile Gly Gly Gly Tyr Gly Thr Lys Tyr Trp Ser Arg Arg Ser Ser           
        115                 120                 125                       

cag gag tgg cgg tgt gtc aat gac aaa acc cgt acc cag aga atc cag        432
Gln Glu Trp Arg Cys Val Asn Asp Lys Thr Arg Thr Gln Arg Ile Gln           
    130                 135                 140                           

ctg cag tgc caa gat ggc agc aca cgc acc tac aaa atc aca gta gtc        480
Leu Gln Cys Gln Asp Gly Ser Thr Arg Thr Tyr Lys Ile Thr Val Val           
145                 150                 155                 160           

act gcc tgc aag tgc aag agg tac acc cgg cag cac aac gag tcc agt        528
Thr Ala Cys Lys Cys Lys Arg Tyr Thr Arg Gln His Asn Glu Ser Ser           
                165                 170                 175               

cac aac ttt gag agc atg tca cct gcc aag cca gtc cag cat cac aga        576
His Asn Phe Glu Ser Met Ser Pro Ala Lys Pro Val Gln His His Arg           
            180                 185                 190                   

gag cgg aaa aga gcc agc aaa tcc agc aag cac agc atg agt tag            621
Glu Arg Lys Arg Ala Ser Lys Ser Ser Lys His Ser Met Ser                   
        195                 200                 205                       


<210>  14
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Leu Pro Pro Ala Ile His Phe Tyr Leu Leu Pro Leu Ala Cys Ile 
1               5                   10                  15      


Leu Met Lys Ser Cys Leu Ala Phe Lys Asn Asp Ala Thr Glu Ile Leu 
            20                  25                  30          


Tyr Ser His Val Val Lys Pro Val Pro Ala His Pro Ser Ser Asn Ser 
        35                  40                  45              


Thr Leu Asn Gln Ala Arg Asn Gly Gly Arg His Phe Ser Asn Thr Gly 
    50                  55                  60                  


Leu Asp Arg Asn Thr Arg Val Gln Val Gly Cys Arg Glu Leu Arg Ser 
65                  70                  75                  80  


Thr Lys Tyr Ile Ser Asp Gly Gln Cys Thr Ser Ile Ser Pro Leu Lys 
                85                  90                  95      


Glu Leu Val Cys Ala Gly Glu Cys Leu Pro Leu Pro Val Leu Pro Asn 
            100                 105                 110         


Trp Ile Gly Gly Gly Tyr Gly Thr Lys Tyr Trp Ser Arg Arg Ser Ser 
        115                 120                 125             


Gln Glu Trp Arg Cys Val Asn Asp Lys Thr Arg Thr Gln Arg Ile Gln 
    130                 135                 140                 


Leu Gln Cys Gln Asp Gly Ser Thr Arg Thr Tyr Lys Ile Thr Val Val 
145                 150                 155                 160 


Thr Ala Cys Lys Cys Lys Arg Tyr Thr Arg Gln His Asn Glu Ser Ser 
                165                 170                 175     


His Asn Phe Glu Ser Met Ser Pro Ala Lys Pro Val Gln His His Arg 
            180                 185                 190         


Glu Arg Lys Arg Ala Ser Lys Ser Ser Lys His Ser Met Ser 
        195                 200                 205     


