                         SEQUENCE LISTING

<110>  aratinga.bio TNP
 
<120>  Aptamer-Bseed Multispecific Therapeutic Agents

<130>  12269-0102

<140>  PCT/IB2020/000623
<141>  2020-07-27

<150>  US 62/879413
<151>  2019-07-26

<150>  US 62/879401
<151>  2019-07-26

<150>  PCT/IB2019/000890
<151>  2019-07-26

<160>  130   

<170>  PatentIn version 3.5

<210>  1
<211>  14
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  1

Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu 
1               5                   10                  


<210>  2
<211>  15
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  2

Glu Ser Gln Pro Asp Pro Lys Pro Asp Glu Leu His Lys Ser Ser 
1               5                   10                  15  


<210>  3
<211>  12
<212>  PRT
<213>  Hepatitis B virus

<400>  3

Pro Arg Val Arg Gly Leu Tyr Phe Pro Ala Gly Gly 
1               5                   10          


<210>  4
<211>  10
<212>  PRT
<213>  Bovine herpesvirus 1

<400>  4

Met Glu Glu Ser Lys Gly Tyr Glu Pro Pro 
1               5                   10  


<210>  5
<211>  9
<212>  PRT
<213>  Salmonella typhimurium

<400>  5

Asp Arg Thr Asn Asn Gln Val Lys Ala 
1               5                   


<210>  6
<211>  7
<212>  PRT
<213>  grapevine leafroll-associated virus 3

<400>  6

Ala Gln Glu Pro Pro Arg Gln 
1               5           


<210>  7
<211>  24
<212>  PRT
<213>  SARS CoV-1

<400>  7

Pro Thr Asp Ser Thr Asp Asn Asn Gln Asn Gly Gly Arg Asn Gly Ala 
1               5                   10                  15      


Arg Pro Lys Gln Arg Arg Pro Gln 
            20                  


<210>  8
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  A10 RNA aptamer anti-PSMA

<400>  8
gggaggacga ugcggaucag ccauguuuac gucacuccu                              39


<210>  9
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 1 aptamer

<400>  9
ccgggtgggg gtttggcacc gggcctggcg cagggattcg                             40


<210>  10
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 2 aptamer

<400>  10
gaggggtttg gcatcgggcc tggcgccatt caagctatgc                             40


<210>  11
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 3 aptamer

<400>  11
gcgtaagggt ttggcagcgg gcctggcgga acgcgtgtat                             40


<210>  12
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 4 aptamer

<400>  12
ggagtggagt attccgggtt tggcatcggg cctggcgaag                             40


<210>  13
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 5 aptamer

<400>  13
cggcaggggt ttggctccgg gtctggcgaa ctggctgaga                             40


<210>  14
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 6 aptamer

<400>  14
aagggattgg cgtcgggcct ggcgtaagga ggctatgctc                             40


<210>  15
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 7 aptamer

<400>  15
gggattggcg ctgggcctgg caaggaatct tctcgttgta                             40


<210>  16
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 8

<400>  16
gggattggct tcgggcctgg cgagtattgt tttcctggag                             40


<210>  17
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 9 aptamer

<400>  17
gcatcgaaat ggggttggca ccgggcctgg cgaattggat                             40


<210>  18
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 10 aptamer

<400>  18
gagactagag ggattggctt cgggcctggc gtac                                   34


<210>  19
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 11 aptamer

<400>  19
gatggagggt ttggcggtgg gcctggcaag ttatctcata                             40


<210>  20
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 12 aptamer

<400>  20
tacggctagg gtttggcgtt gggcctggca ggaccgtaag                             40


<210>  21
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 13 aptamer

<400>  21
atatgggagg gtgagggttt ggctgcgggc ctggcgggag                             40


<210>  22
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 14 aptamer

<400>  22
tgcggcacat gtacgcggag ggattggcat agggtctggc                             40


<210>  23
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 15 aptamer

<400>  23
ggggttggct ttgggcctgg cagtcatttg tgaatcctta                             40


<210>  24
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 16 aptamer

<400>  24
tccgacaaaa gggattggct tcgggcctgg cggggttgcc                             40


<210>  25
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 17 aptamer

<400>  25
ggtcggggtt tggcatcggg actggcgtta tacaatcgt                              39


<210>  26
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 18 aptamer

<400>  26
gatggggttt ggcgtcgggc ctggcgaata catctaaaag                             40


<210>  27
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 19 aptamer

<400>  27
taccgcgggg attggctccg ggcctggcgt cgtaatctga                             40


<210>  28
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 20 aptamer

<400>  28
ggggtttggc tgcgggcctg gcgcatgatt caacgagaca                             40


<210>  29
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 21 aptamer

<400>  29
ggtcgggtgc tactgagcga ttggctttcc ggactgggga                             40


<210>  30
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 22 aptamer

<400>  30
cgaccacagg ggtttggctt cgggactggc ggtgggcact                             40


<210>  31
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 23 aptamer

<400>  31
cgaccacagg ggtttggctt cgggactggc ggtgggcact                             40


<210>  32
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 24 aptamer

<400>  32
tatgggtttg gcatcgggcc tggcggaatg gaaaatgtta                             40


<210>  33
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 25 aptamer

<400>  33
agacgggttt ggctgcgggc ctggcggtcg tcattcctct                             40


<210>  34
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 26 aptamer

<400>  34
gaggggattg gcatttgggc ctggcaaatt catctattct                             40


<210>  35
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 27 aptamer

<400>  35
aggggtttgg cgtcgggcct ggcgcagctc ttcttgtgtt t                           41


<210>  36
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 28 aptamer

<400>  36
gggattggct tcgggcctgg cgtatctttt acattacc                               38


<210>  37
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 29 aptamer

<400>  37
ggtggacggt atacaggggc tgctcaggat tgcggatgat                             40


<210>  38
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 30 aptamer

<400>  38
ccgtttgaag cgttagggtt tggcatcggg cctggcgcac                             40


<210>  39
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 31 aptamer

<400>  39
agggtttggc tacgggcctg gcgagctgtt tccgctactc                             40


<210>  40
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 32 aptamer

<400>  40
gtgttatgat actatgcgta tggattgcaa agggctgctg                             40


<210>  41
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 33 aptamer

<400>  41
gaagggtttg gcattgggcc tggcaagata atttgcaagt                             40


<210>  42
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 34 aptamer

<400>  42
cggcgaagtg gcagggtttg gcttcgggtc tggcggaaca                             40


<210>  43
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 35 aptamer

<400>  43
gagggtttgg cagtgggcct ggcatcaatt ctttgttttc                             40


<210>  44
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 36 aptamer

<400>  44
tactgagggt ttggcattgg gcctggcata ttggtattt                              39


<210>  45
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 37 aptamer

<400>  45
atgggtttgg caccgggtct ggcggattcg ataggtggtt                             40


<210>  46
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 38 aptamer

<400>  46
gggggtttgg ctctgggcct ggcataacga accttcggag                             40


<210>  47
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 39 aptamer

<400>  47
tgcccgagag gactgcttag gcttgcgagt agggaacgct                             40


<210>  48
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 40 aptamer

<400>  48
agtgggattg gcttcgggcc tggcgttcgc aacatgttta                             40


<210>  49
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 41 aptamer

<400>  49
ggggattggc actgggactg gcaccttttt aacatgtatg                             40


<210>  50
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 42 aptamer

<400>  50
gcaattaagg gattggctcc gggcctggcg ccacgcatgg                             40


<210>  51
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 43 aptamer

<400>  51
tggggtttgg cagcgggtct ggcgatcata atggtgtgcg                             40


<210>  52
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 44 aptamer

<400>  52
acgggggatt ggctttgggc ctggcaatta atttactgtt                             40


<210>  53
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cluster 45 aptamer

<400>  53
gagcgcttgg cagccggtct ggggacatca gaggtgatgg                             40


<210>  54
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC_1s aptamer

<400>  54
tttccgggtg ggggtttggc accgggcctg gcgcagggat tcg                         43


<210>  55
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC_2s aptamer

<400>  55
gaggggtttg gcatcgggcc tggcgccatt caagctatgc                             40


<210>  56
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC_3s aptamer

<400>  56
gcgtaagggt ttggcagcgg gcctggcgga acgcgtgtat                             40


<210>  57
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC_21s aptamer

<400>  57
ggtcgggtgc tactgagcga ttggctttcc ggactgggga                             40


<210>  58
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC_4s aptamer

<400>  58
ggagtggagt attccgggtt tggcatcggg cctggcgaag                             40


<210>  59
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC_5s aptamer

<400>  59
cggcaggggt ttggctccgg gtctggcgaa ctggctgaga                             40


<210>  60
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC_6s sequence

<400>  60
aagggattgg cgtcgggcct ggcgtaagga ggctatgctc                             40


<210>  61
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC_9s aptamer

<400>  61
gcatcgaaat ggggttggca ccgggcctgg cgaattggat                             40


<210>  62
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC_11s aptamer

<400>  62
gatggagggt ttggcggtgg gcctggcaag ttatctcata                             40


<210>  63
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC_19s aptamer

<400>  63
taccgcgggg attggctccg ggcctggcgt cgtaatctga                             40


<210>  64
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC_22s aptamer

<400>  64
cgaccacagg ggtttggctt cgggactggc ggtgggcact                             40


<210>  65
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core aptamer


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is a, c, g, or t

<400>  65
gggnttggcn nngggnctgg c                                                 21


<210>  66
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_1 aptamer

<400>  66
gggtttggca ccgggcctgg cgc                                               23


<210>  67
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_2 aptamer

<400>  67
gggtttggca ccgggcctgg c                                                 21


<210>  68
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_3 aptamer

<400>  68
ccgggcctgg cc                                                           12


<210>  69
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_4 aptamer

<400>  69
gggtttggca tcgggcctgg cg                                                22


<210>  70
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_5 aptamer

<400>  70
gggtttggcg gtgggcctgg c                                                 21


<210>  71
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_6 aptamer

<400>  71
tttgggtttg gcaccgggcc tggc                                              24


<210>  72
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_T aptamer

<400>  72
tttgggtttg gcatcgggcc tggc                                              24


<210>  73
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_7 aptamer


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a, c, g, or t

<400>  73
gggtttngca ccgggcctgg c                                                 21


<210>  74
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_8 aptamer


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is a, c, g, or t

<400>  74
gggtttgnca ccgggcctgg c                                                 21


<210>  75
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_9 aptamer


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is a, c, g, or t

<400>  75
gggtttggna ccgggcctgg c                                                 21


<210>  76
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_10 aptamer


<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is a, c, g, or t

<400>  76
gggtttggca ccnggcctgg c                                                 21


<210>  77
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_11 aptamer


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or t

<400>  77
gggtttggca ccggncctgg c                                                 21


<210>  78
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_12 aptamer


<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is a, c, g, or t

<400>  78
gggtttggca ccgggnctgg c                                                 21


<210>  79
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_13 aptamer


<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is a, c, g, or t

<400>  79
gggtttggca ccgggcntgg c                                                 21


<210>  80
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_14 aptamer


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or t

<400>  80
nggtttggca tcgggcctgg c                                                 21


<210>  81
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_15 aptamer


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is a, c, g, or t

<400>  81
gngtttggca tcgggcctgg c                                                 21


<210>  82
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_16 aptamer


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is a, c, g, or t

<400>  82
ggntttggca tcgggcctgg c                                                 21


<210>  83
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_17 aptamer


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is a, c, g, or t

<400>  83
gggnttggca tcgggcctgg c                                                 21


<210>  84
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_18 aptamer


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is a, c, g, or t

<400>  84
gggtntggca tcgggcctgg c                                                 21


<210>  85
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_19 aptamer


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, or t

<400>  85
gggttnggca tcgggcctgg c                                                 21


<210>  86
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_20 aptamer


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a, c, g, or t

<400>  86
gggtttngca tcgggcctgg c                                                 21


<210>  87
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_21 aptamer


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is a, c, g, or t

<400>  87
gggtttgnca tcgggcctgg c                                                 21


<210>  88
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_22 aptamer


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  n is a, c, g, or t

<400>  88
gggtttggna tcgggcctgg c                                                 21


<210>  89
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_23 aptamer


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is a, c, g, or t

<400>  89
gggtttggcn tcgggcctgg c                                                 21


<210>  90
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_24 aptamer


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is a, c, g, or t

<400>  90
gggtttggca ncgggcctgg c                                                 21


<210>  91
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_25 aptamer


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is a, c, g, or t

<400>  91
gggtttggca tngggcctgg c                                                 21


<210>  92
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_26 aptamer


<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  n is a, c, g, or t

<400>  92
gggtttggca tcnggcctgg c                                                 21


<210>  93
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_27 aptamer


<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  n is a, c, g, or t

<400>  93
gggtttggca tcgngcctgg c                                                 21


<210>  94
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_28 aptamer


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or t

<400>  94
gggtttggca tcggncctgg c                                                 21


<210>  95
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_29 aptamer


<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is a, c, g, or t

<400>  95
gggtttggca tcgggnctgg c                                                 21


<210>  96
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_30 aptamer


<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  n is a, c, g, or t

<400>  96
gggtttggca tcgggcntgg c                                                 21


<210>  97
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_31 aptamer


<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  n is a, c, g, or t

<400>  97
gggtttggca tcgggccngg c                                                 21


<210>  98
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_32 aptamer


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  n is a, c, g, or t

<400>  98
gggtttggca tcgggcctng c                                                 21


<210>  99
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_33 aptamer


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  n is a, c, g, or t

<400>  99
gggtttggca tcgggcctgn c                                                 21


<210>  100
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_34 aptamer


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  n is a, c, g, or t

<400>  100
gggtttggca tcgggcctgg n                                                 21


<210>  101
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_35 aptamer

<400>  101
gggtttggga tcgggcctgg c                                                 21


<210>  102
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_36 aptamer

<400>  102
gggtttggca tcgggcctgg g                                                 21


<210>  103
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_37 aptamer

<400>  103
gggtttggga tcgggcctgg g                                                 21


<210>  104
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_38 aptamer

<400>  104
gggtttggca tcgggactgg c                                                 21


<210>  105
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_39 aptamer

<400>  105
gggtttggca tcggggctgg c                                                 21


<210>  106
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_40 aptamer

<400>  106
gggtttggca tcgggtctgg c                                                 21


<210>  107
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_41 aptamer

<400>  107
gggtttggca tcgggctggc                                                   20


<210>  108
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_42 aptamer


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is a, c, g, or t

<400>  108
gggtttggca ncgggnctgg c                                                 21


<210>  109
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_43 aptamer


<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is a, c, g, or t

<400>  109
gggtttggca gcgggnctgg c                                                 21


<210>  110
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CELTIC core_44 aptamer


<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is a, c, g, or t

<400>  110
gggtttggca acgggnctgg c                                                 21


<210>  111
<211>  48
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ARACD3-0010209 aptamer

<400>  111
ucuaagcaau auuguuugcu uuugcagcga uucuguuucg auauauua                    48


<210>  112
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ARACD3-2980001 aptamer

<400>  112
uucaagauaa uguaauuauu uuugcagcga uucuuguuuu guucgauuu                   49


<210>  113
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ARACD3-0270039 aptamer

<400>  113
caaaguucaa gauugagcuu uuugcagcga uucuuguuuu aucaaacga                   49


<210>  114
<211>  48
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ARACD3-3130001 aptamer

<400>  114
gaugauaucu uuaauaucaa uugcagcgau ucuuguuuga gaauaaac                    48


<210>  115
<211>  50
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ARACD3-3700006 aotamer

<400>  115
uauagacuuu aaugucucau uuucgcagcg auucuuguuu auuuaacaua                  50


<210>  116
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Core sequence RNA aptamer


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is a, c, g, or u

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  n is a, c, g, or u

<400>  116
ungcagcgau ucunnuu                                                      17


<210>  117
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Consensus-1 aptamer

<400>  117
grdtkgsydb hsgghctgg                                                    19


<210>  118
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Consensus-2 aptamer

<400>  118
gggrttggcr bhggghctgg c                                                 21


<210>  119
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Consensus-3 aptamer

<400>  119
gdttdgsywb csggmctggs g                                                 21


<210>  120
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Consensus-4 aptamer

<400>  120
gggtttggca bcgggcctgg c                                                 21


<210>  121
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Consensus-5 aptamer


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  n is a, c, g, or u

<400>  121
gcagcgauuc unguuu                                                       16


<210>  122
<211>  86
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA aptamer library


<220>
<221>  misc_feature
<222>  (24)..(63)
<223>  n is a, c, g, or t

<400>  122
tagggaagag aaggacatat gatnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60

nnnttgacta gtacatgacc acttga                                            86


<210>  123
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer for DNA SELEX

<400>  123
tagggaagag aaggacatat gat                                               23


<210>  124
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer for DNA SELEX

<400>  124
tcaagtggtc atgtactagt caa                                               23


<210>  125
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA aptamer library


<220>
<221>  misc_feature
<222>  (24)..(43)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (65)..(74)
<223>  n is a, c, g, or t

<400>  125
cctctctatg ggcagtcggt gatnnnnnnn nnnnnnnnnn nnntttctgc agcgattctt       60

gtttnnnnnn nnnnggagaa tgaggaaccc agtgcag                                97


<210>  126
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer for RNA SELEX

<400>  126
taatacgact cactataggg cctctctatg ggcagtcggt gat                         43


<210>  127
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer for RNA SELEX

<400>  127
ctgcactggg ttcctcattc tcc                                               23


<210>  128
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward blocking sequence for RNA SELEX

<400>  128
atcaccgact gcccatagag agg                                               23


<210>  129
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse blocking sequence for RNA SELEX

<400>  129
ctgcactggg ttcctcattc tcc                                               23


<210>  130
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  capture sequence for RNA SELEX

<400>  130
caagaatcgc tgcag                                                        15


