                         SEQUENCE LISTING

<110>  Scancell Limited
 
<120>  BINDING MEMBERS

<130>  P125851WO

<150>  GB1910899.2
<151>  2019-07-31

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  1401
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Heavy chain DNA sequence of 27.10

<400>  1
atgaacttct ggctcagctt gattttcctt gtccttgttt taaaaggtgt ccagtgtgaa       60

gtgaagctgg tggagtctgg gggaggctta gtgcagcctg gagggtccct gaaactctcc      120

tgtgcaacct ctggattcac tttcagtcac tattacatgt attgggttcg ccagactcca      180

gagaagaggc tggagtgggt cgcatacatt agtaatgatg gtgataacac ctattatcca      240

gacactataa ggggccgatt caccatctcc agagacaatg ccaggaacac cctgtacctg      300

caaatgagcc gtctgaagtc tgaggacaca gccatgtatt actgtgcaag agggaagtac      360

gacggggcct ggtttgctta ctggggccaa gggactctgg tcactgtctc tgcagctaca      420

acaacagccc catctgtcta tcccttggtc cctggctgca gtgacacatc tggatcctcg      480

gtgacactgg gatgccttgt caaaggctac ttccctgagc cggtaactgt aaaatggaac      540

tatggagccc tgtccagcgg tgtgcgcaca gtctcatctg tcctgcagtc tgggttctat      600

tccctcagca gcttggtgac tgtaccctcc agcacctggc ccagccagac tgtcatctgc      660

aacgtagccc acccagccag caagactgag ttgatcaaga gaatcgagcc tagaataccc      720

aagcccagta cccccccagg ttcttcatgc ccacctggta acatcttggg tggaccatcc      780

gtcttcatct tccccccaaa gcccaaggat gcactcatga tctccctaac ccccaaggtt      840

acgtgtgtgg tggtggatgt gagcgaggat gacccagatg tccatgtcag ctggtttgtg      900

gacaacaaag aagtacacac agcctggaca cagccccgtg aagctcagta caacagtacc      960

ttccgagtgg tcagtgccct ccccatccag caccaggact ggatgagggg caaggagttc     1020

aaatgcaagg tcaacaacaa agccctccca gcccccatcg agagaaccat ctcaaaaccc     1080

aaaggaagag cccagacacc tcaagtatac accatacccc cacctcgtga acaaatgtcc     1140

aagaagaagg ttagtctgac ctgcctggtc accaacttct tctctgaagc catcagtgtg     1200

gagtgggaaa ggaacggaga actggagcag gattacaaga acactccacc catcctggac     1260

tcagatggga cctacttcct ctacagcaag ctcactgtgg atacagacag ttggttgcaa     1320

ggagaaattt ttacctgctc cgtggtgcat gaggctctcc ataaccacca cacacagaag     1380

ctgtctcgct cccctggtaa a                                               1401


<210>  2
<211>  465
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain protein sequence of 27.10

<400>  2

Met Asn Phe Trp Leu Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


Tyr Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp 
    50                  55                  60                  


Val Ala Tyr Ile Ser Asn Asp Asp Asn Thr Tyr Tyr Pro Asp Thr Ile 
65                  70                  75                  80  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
                85                  90                  95      


Leu Gln Met Ser Arg Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
            100                 105                 110         


Ala Arg Gly Lys Tyr Asp Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ala Ala Thr Thr Thr Ala Pro Ser Val Tyr 
    130                 135                 140                 


Pro Leu Val Pro Gly Cys Ser Asp Thr Ser Gly Ser Ser Val Thr Leu 
145                 150                 155                 160 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Lys Trp 
                165                 170                 175     


Asn Tyr Gly Ala Leu Ser Ser Gly Val Arg Thr Val Ser Ser Val Leu 
            180                 185                 190         


Gln Ser Gly Phe Tyr Ser Leu Ser Ser Leu Val Thr Val Pro Ser Ser 
        195                 200                 205             


Thr Trp Pro Ser Gln Thr Val Ile Cys Asn Val Ala His Pro Ala Ser 
    210                 215                 220                 


Lys Thr Glu Leu Ile Lys Arg Ile Glu Pro Arg Ile Pro Lys Pro Ser 
225                 230                 235                 240 


Thr Pro Pro Gly Ser Ser Cys Pro Pro Gly Asn Ile Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Ala Leu Met Ile Ser 
            260                 265                 270         


Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp 
        275                 280                 285             


Pro Asp Val His Val Ser Trp Phe Val Asp Asn Lys Glu Val His Thr 
    290                 295                 300                 


Ala Trp Thr Gln Pro Arg Glu Ala Gln Tyr Asn Ser Thr Phe Arg Val 
305                 310                 315                 320 


Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Arg Gly Lys Glu 
                325                 330                 335     


Phe Lys Cys Lys Val Asn Asn Lys Ala Leu Pro Ala Pro Ile Glu Arg 
            340                 345                 350         


Thr Ile Ser Lys Pro Lys Gly Arg Ala Gln Thr Pro Gln Val Tyr Thr 
        355                 360                 365             


Ile Pro Pro Pro Arg Glu Gln Met Ser Lys Lys Lys Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Thr Asn Phe Phe Ser Glu Ala Ile Ser Val Glu Trp Glu 
385                 390                 395                 400 


Arg Asn Gly Glu Leu Glu Gln Asp Tyr Lys Asn Thr Pro Pro Ile Leu 
                405                 410                 415     


Asp Ser Asp Gly Thr Tyr Phe Leu Tyr Ser Lys Leu Thr Val Asp Thr 
            420                 425                 430         


Asp Ser Trp Leu Gln Gly Glu Ile Phe Thr Cys Ser Val Val His Glu 
        435                 440                 445             


Ala Leu His Asn His His Thr Gln Lys Asn Leu Ser Arg Ser Pro Gly 
    450                 455                 460                 


Lys 
465 


<210>  3
<211>  1386
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Heavy chain DNA sequence of 27.18

<400>  3
atgaacttct ggctcagctt gattttcctt gtccttgttt taaaaggtgt ccagtgtgaa       60

gtgaagctgg tggagtctgg gggaggctta gtgcagcctg gagggtccct gaaactctcc      120

tgtgcaacct ctggattcac tttcagtcac tattacatgt attgggttcg ccagactcca      180

gagaagaggc tggagtgggt cgcatacatt agtaatgatg gtgataacac ctattatcca      240

gacactataa ggggccgatt caccatctcc agagacaatg ccaggaacac cctgtacctg      300

caaatgagcc gtctgaagtc tgaggacaca gccatgtatt actgtgcaag agggaagtac      360

gacggggcct ggtttgctta ctggggccaa gggactctgg tcactgtctc tgcagccaaa      420

acgacacccc catctgtcta tccactggcc cctggatctg ctgcccaaac taactccatg      480

gtgaccctgg gatgcctggt caagggctat ttccctgagc cagtgacagt gacctggaac      540

tctggatccc tgtccagcgg tgtgcacacc ttcccagctg tcctggagtc tgacctctac      600

actctgagca gctcagtgac tgtcccctcc agccctcggc ccagcgagac cgtcacctgc      660

aacgttgccc acccggccag cagcaccaag gtggacaaga aaattgtgcc cagggattgt      720

ggttgtaagc cttgcatatg tacagtccca gaagtatcat ctgtcttcat cttcccccca      780

aagcccaagg atgtgctcac cattactctg actcctaagg tcacgtgtgt tgtggtagac      840

atcagcaagg atgatcccga ggtccagttc agctggtttg tagatgatgt ggaggtgcac      900

acagctcaga cgcaaccccg ggaggagcag ttcaacagca ctttccgctc agtcagtgaa      960

cttcccatca tgcaccagga ctggctcaat ggcaaggagt tcaaatgcag ggtcaacagt     1020

gcagctttcc ctgcccccat cgagaaaacc atctccaaaa ccaaaggcag accgaaggct     1080

ccacaggtgt acaccattcc acctcccaag gagcagatgg ccaaggataa agtcagtctg     1140

acctgcatga taacagactt cttccctgaa gacattactg tggagtggca gtggaatggg     1200

cagccagcgg agaactacaa gaacactcag cccatcatga acacgaatgg ctcttacttc     1260

gtctacagca agctcaatgt gcagaagagc aactgggagg caggaaatac tttcacctgc     1320

tctgtgttac atgagggcct gcacaaccac catactgaga agagcctctc ccactctcct     1380

ggtaaa                                                                1386


<210>  4
<211>  461
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain protein sequence of 27.18

<400>  4

Met Asn Phe Trp Leu Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


His Tyr Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu 
    50                  55                  60                  


Trp Val Ala Tyr Ile Ser Asn Asp Gly Asp Asn Thr Tyr Tyr Pro Asp 
65                  70                  75                  80  


Thr Ile Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Ser Arg Leu Lys Ser Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Lys Tyr Asp Gly Ala Trp Phe Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 
145                 150                 155                 160 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Glu Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro 
        195                 200                 205             


Ser Ser Pro Arg Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro 
    210                 215                 220                 


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly 
225                 230                 235                 240 


Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln 
        275                 280                 285             


Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln 
    290                 295                 300                 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu 
305                 310                 315                 320 


Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg 
                325                 330                 335     


Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro 
        355                 360                 365             


Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr 
    370                 375                 380                 


Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln 
385                 390                 395                 400 


Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr Asn Gly 
                405                 410                 415     


Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu 
            420                 425                 430         


Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn 
        435                 440                 445             


His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460     


<210>  5
<211>  714
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Light chain DNA sequence FG27.10

<400>  5
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc catcagtgat       60

gttttgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc      120

tcttgcagat ctagtcagat cattgtacat actaatggaa acacctattt agaatggtac      180

ctgcagaaac caggccagtc tccaaacctc ctgatctaca aagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggagtttat tactgctttc aaggttcaca tgttccattc      360

acgttcggct cggggacaaa gttggaaata aaacgggctg atgctgcacc aactgtatcc      420

atcttcccac catccagtga gcagttaaca tctggaggtg cctcagtcgt gtgcttcttg      480

aacaacttct accccaaaga catcaatgtc aagtggaaga ttgatggcag tgaacgacaa      540

aatggcgtcc tgaacagttg gactgatcag gacagcaaag acagcaccta cagcatgagc      600

agcaccctca cgttgaccaa ggacgagtat gaacgacata acagctatac ctgtgaggcc      660

actcacaaga catcaacttc acccattgtc aagagcttca acaggaatga gtgt            714


<210>  6
<211>  238
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Light chain protein sequence FG27.10

<400>  6

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ile Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ile Ile 
        35                  40                  45              


Val His Thr Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Asn Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         


Phe Gln Gly Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 
                165                 170                 175     


Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 
        195                 200                 205             


Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 
    210                 215                 220                 


Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235             


<210>  7
<211>  1404
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Heavy chain DNA sequence CH27.10

<400>  7
atgaacttct ggctcagctt gattttcctt gtccttgttt taaaaggtgt ccagtgtgaa       60

gtgaagctgg tggagtctgg gggaggctta gtgcagcctg gagggtccct gaaactctcc      120

tgtgcaacct ctggattcac tttcagtcac tattacatgt attgggttcg ccagactcca      180

gagaagaggc tggagtgggt cgcatacatt agtaatgatg gtgataacac ctattatcca      240

gacactataa ggggccgatt caccatctcc agagacaatg ccaggaacac cctgtacctg      300

caaatgagcc gtctgaagtc tgaggacaca gccatgtatt actgtgcaag agggaagtac      360

gacggggcct ggtttgctta ctggggccaa gggactctgg tcactgtctc tagcgcttcc      420

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      480

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      540

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      600

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      660

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      720

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      780

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      840

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      900

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1020

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     1080

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1260

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1320

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1380

agcctctccc tgtctccggg taaa                                            1404


<210>  8
<211>  467
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain protein sequence CH27.10

<400>  8

Met Asn Phe Trp Leu Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


His Tyr Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu 
    50                  55                  60                  


Trp Val Ala Tyr Ile Ser Asn Asp Gly Asp Asn Thr Tyr Tyr Pro Asp 
65                  70                  75                  80  


Thr Ile Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Ser Arg Leu Lys Ser Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Lys Tyr Asp Gly Ala Trp Phe Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  9
<211>  714
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CH27.10 light chain DNA sequence

<400>  9
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc catcagtgat       60

gttttgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc      120

tcttgcagat ctagtcagat cattgtacat actaatggaa acacctattt agaatggtac      180

ctgcagaaac caggccagtc tccaaacctc ctgatctaca aagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggagtttat tactgctttc aaggttcaca tgttccattc      360

acgttcggct cggggacaaa gttggaaata aaacgtacgg tagcggcccc atctgtcttc      420

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      480

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      540

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      600

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      660

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt            714


<210>  10
<211>  238
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CH27.10 light chain protein sequence

<400>  10

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ile Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ile Ile 
        35                  40                  45              


Val His Thr Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Asn Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         


Phe Gln Gly Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  11
<211>  357
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FG27 RHA

<400>  11
caggtccagc tggtcgaatc agggggaggc gtcgtgcagc ccggaaggtc actgagactg       60

tcatgtgccg catcagggtt tactttctca cactactata tgtactgggt gcgacaggct      120

ccaggcaagg gactggagtg ggtcgcatat atcagcaacg acggcgataa tacttactat      180

cctgacacca tccgggggag attcacaatc tctagagata acagtaagaa cactctgtac      240

ctgcagatga actctctgag ggcagaagac accgccgtgt actattgcgc ccgcgggaaa      300

tacgatggag cctggtttgc ttattgggga cagggcaccc tggtgacagt cagctcc         357


<210>  12
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FG27 RHA

<400>  12

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Asn Asp Gly Asp Asn Thr Tyr Tyr Pro Asp Thr Ile 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Tyr Asp Gly Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  13
<211>  990
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HuG1 DNA sequence

<400>  13
gcctccacca agggcccttc cgtgttccct ctggcccctt cctccaagtc cacctccggc       60

ggcaccgccg ctctgggctg cctggtgaag gactacttcc ctgagcctgt gaccgtgtcc      120

tggaactctg gcgccctgac cagcggcgtg cacaccttcc ctgccgtgct gcagtcctcc      180

ggcctgtact ccctgtcctc cgtggtgacc gtgccttcct cctccctggg cacccagacc      240

tacatctgca acgtgaacca caagccttcc aacaccaagg tggacaagaa ggtggagcct      300

aagtcctgcg acaagaccca cacgtgccct ccatgcccag ctcccgagct gctgggcgga      360

ccaagcgtgt ttctgttccc tcctaagcct aaggacaccc tgatgatctc ccggacccct      420

gaggtgacgt gcgtggtggt ggacgtgtcc cacgaggacc cagaggtgaa gttcaattgg      480

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc ctcgggagga acagtacaac      540

tccacctacc gggtggtgtc tgtgctgacc gtgctgcacc aggactggct gaacggcaag      600

gaatacaagt gcaaagtctc caacaaggcc ctgcctgccc ccatcgaaaa gaccatctcc      660

aaggccaagg gccagcctcg cgagcctcag gtgtacaccc tgcctccaag cagggaggaa      720

atgaccaaga accaggtgtc cctgacctgt ctggtgaagg gcttctaccc ttccgatatc      780

gccgtggagt gggagtccaa cggccagcct gagaacaact acaagaccac ccctcctgtg      840

ctggactccg acggctcctt cttcctgtac tccaagctga ccgtggacaa gtcccggtgg      900

cagcagggca acgtgttctc ctgctccgtg atgcacgagg ccctgcacaa ccactacacc      960

cagaagagcc tctccctgtc cccgggtaaa                                       990


<210>  14
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HuG1 protein sequence

<400>  14

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  15
<211>  396
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FG27 RKC DNA sequence

<400>  15
atggaagccc cagcgcagct tctcttcctc ctgctactct ggctccctga taccaccgga       60

gacgtcgtga tgacccagag cccactgagc ctgcctgtga cacccggcga gcccgcaagt      120

atttcctgta gaagttccca gattatcgtg cacactaacg ggaataccta cctggagtgg      180

tatctgcaga agcccggcca gagtcctcag ctgctgatct acaaagtgag taaccggttc      240

tcaggagtcc cagaccggtt cagcggctcc gggtctggaa ccgatttcac actgaagatt      300

agcagggtgg aggccgaaga cgtgggagtc tactattgct ttcagggctc ccatgtcccc      360

ttcacatttg gccaggggac caagctggaa atcaaa                                396


<210>  16
<211>  132
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FG27 RKC protein sequence

<400>  16

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ile 
        35                  40                  45              


Ile Val His Thr Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Phe Gln Gly Ser His Val Pro Phe Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys 
    130         


<210>  17
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HuK DNA sequence

<400>  17
agaactgtgg cagcaccaag cgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg t                                                321


<210>  18
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  HuK protein sequence

<400>  18

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  19
<211>  714
<212>  DNA
<213>  Artificial sequence

<220>
<223>  27 Light chain DNA sequence (variable region + Kappa constant)

<400>  19
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc catcagtgat       60

gttttgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc      120

tcttgcagat ctagtcagat cattgtacat actaatggaa acacctattt agaatggtac      180

ctgcagaaac caggccagtc tccaaacctc ctgatctaca aagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggagtttat tactgctttc aaggttcaca tgttccattc      360

acgttcggct cggggacaaa gttggaaata aaacgtacgg tagcggcccc atctgtcttc      420

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      480

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      540

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      600

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      660

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt            714


<210>  20
<211>  238
<212>  PRT
<213>  Artificial sequence

<220>
<223>  27 Light chain protein sequence (variable region + Kappa 
       constant)

<400>  20

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ile Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ile Ile 
        35                  40                  45              


Val His Thr Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Asn Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         


Phe Gln Gly Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  21
<211>  1404
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Heavy chain DNA sequence of i27v1 (variable + 'improved' v1 
       constant region)

<400>  21
atgaacttct ggctcagctt gattttcctt gtccttgttt taaaaggtgt ccagtgtgaa       60

gtgaagctgg tggagtctgg gggaggctta gtgcagcctg gagggtccct gaaactctcc      120

tgtgcaacct ctggattcac tttcagtcac tattacatgt attgggttcg ccagactcca      180

gagaagaggc tggagtgggt cgcatacatt agtaatgatg gtgataacac ctattatcca      240

gacactataa ggggccgatt caccatctcc agagacaatg ccaggaacac cctgtacctg      300

caaatgagcc gtctgaagtc tgaggacaca gccatgtatt actgtgcaag agggaagtac      360

gacggggcct ggtttgctta ctggggccaa gggactctgg tcactgtctc tagcgcttcc      420

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca      480

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      540

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc      600

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc      660

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct      720

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      780

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      840

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      900

gacggcgtgg aggtgcatac agcctggaca cagccccgtg aagagcagta caacagtacc      960

taccgagtgg tcagtgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1020

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaaccc     1080

aaaggaagag cccagacacc tcaagtatac accatacccc cacctcgtga acaaatgtcc     1140

aagaagaagg ttagtctgac ctgcctggtc accaacttct tctctgaagc catcagtgtg     1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1260

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1320

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1380

agcctctccc tgtctccggg taaa                                            1404


<210>  22
<211>  468
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain Protein sequence of i27v1 (variable + 'improved' v1 
       constant region)

<400>  22

Met Asn Phe Trp Leu Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser His Tyr Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Tyr Ile Ser Asn Asp Gly Asp Asn Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Ile Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Arg Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Lys Tyr Asp Gly Ala Trp Phe Ala Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Thr Ala Trp Thr Gln Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Pro Lys Gly Arg Ala Gln Thr Pro Gln 
        355                 360                 365             


Val Tyr Thr Ile Pro Pro Pro Arg Glu Gln Met Ser Lys Lys Lys Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Thr Asn Phe Phe Ser Glu Ala Ile Ser Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


