                         SEQUENCE LISTING

<110>  ɽҽҩ޹˾
 
<120>  p40弰;

<130>  IP200460

<160>  54    

<170>  PatentIn version 3.3

<210>  1
<211>  119
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  1

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ser Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Met Ser Pro Val Asp Ser Asp Ile Arg Tyr Asn Pro Met Phe 
    50                  55                  60                  


Arg Gly Gln Val Thr Met Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Pro Gly Gln Gly Tyr Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  2
<211>  357
<212>  DNA
<213>  ˹

<220>
<223>  ˹

<400>  2
gaggtgcagc tggtgcagtc tggggccgaa gtgaagaaac ccggggagag tctgaagatc     60

tcatgccaga gctccggcta ctccttcacc acatattgga tcgggtgggt gagacagatg    120

cctggccagg ggctggaatg gatcggaatt atgagcccag tggactccga tattcgctac    180

aaccccatgt ttcgaggcca ggtgacaatg agcgtggaca agtctagttc aactgcttat    240

ctgcagtgga gctccctgaa agccagcgat accgctatgt actattgtgc ccggagaagg    300

cctggacagg gctacttcga cttttggggg cagggaacta tggtgaccgt ctctagt       357


<210>  3
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  3

Gly Tyr Ser Phe Thr Thr Tyr Trp 
1               5               


<210>  4
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  4

Met Ser Pro Val Asp Ser Asp Ile 
1               5               


<210>  5
<211>  12
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  5

Ala Arg Arg Arg Pro Gly Gln Gly Tyr Phe Asp Phe 
1               5                   10          


<210>  6
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  6

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Arg Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ile Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  7
<211>  321
<212>  DNA
<213>  ˹

<220>
<223>  ˹

<400>  7
gatattcaga tgacccagag cccttcaagc ctgtccgcaa gcgtcgggga tagagtgacc     60

attacctgta aagcaagcca gaacgtggga agctggctgg cctggtacca gcagaagcca    120

ggcaaagcac ccaagtctct gatctatagt gcaagctccc ggcagtcagg agtgccaagc    180

agattcagtg gctcagggag cggaacagac tttaccctga caatctctag tctgcagcct    240

gaggacttcg caacttacta ttgccagcag tacgatatct acccattcac atttggccag    300

gggactaaac tggagatcaa g                                              321


<210>  8
<211>  6
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  8

Gln Asn Val Gly Ser Trp 
1               5       


<210>  9
<211>  3
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  9

Ala Ser Ser 
1           


<210>  10
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  10

Gln Gln Tyr Asp Ile Tyr Pro Phe Thr 
1               5                   


<210>  11
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  11

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  12
<211>  321
<212>  DNA
<213>  ˹

<220>
<223>  ˹

<400>  12
gagatcgtcc tgacacagag tcctgctacc ctgagcgctt ccccaggaga gagggcaacc     60

atctcctgcc gcgcctctca gagcgttggc tcctggctgg cttggtacca gcagaagcca    120

ggccaggcac cccgaagcct gatctatgcc gcttctaatc tgcagagcgg gattcccgct    180

agattctctg gcagtgggtc aggaacagac tttaccctga caatctcaag cctggagcct    240

gaagatttcg ccgtgtacta ttgccagcag tacaacatct acccatatac atttggccag    300

gggactcggc tggagatcaa g                                              321


<210>  13
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  13

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Leu Gln Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  14
<211>  321
<212>  DNA
<213>  ˹

<220>
<223>  ˹

<400>  14
gagatcgtcc tgacacagag tcctgctacc ctgagcgctt ccccaggaga gagggcaacc     60

atctcctgcc gcgcctctca gagcgttagc tcctggctgg cttggtacca gcagaagcca    120

ggccaggcac cccgaagcct gatctattcc gcttctaatc tgcagagcgg gattcccgct    180

agattctctg gcagtgggtc aggaacagac tttaccctga caatctcaag cctggagcct    240

gaagatttcg ccgtgtacta ttgccagcag tacaacatct acccatatac atttggccag    300

gggactcggc tggagatcaa g                                              321


<210>  15
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  15

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Arg Gln Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  16
<211>  321
<212>  DNA
<213>  ˹

<220>
<223>  ˹

<400>  16
gagatcgtcc tgacacagag tcctgctacc ctgagcgctt ccccaggaga gagggcaacc     60

atctcctgcc gcgcctctca gagcgttagc tcctggctgg cttggtacca gcagaagcca    120

ggccaggcac cccgaagcct gatctatgcc gcttctaatc ggcagagcgg gattcccgct    180

agattctctg gcagtgggtc aggaacagac tttaccctga caatctcaag cctggagcct    240

gaagatttcg ccgtgtacta ttgccagcag tacaacatct acccatatac atttggccag    300

gggactcggc tggagatcaa g                                              321


<210>  17
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  17

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  18
<211>  321
<212>  DNA
<213>  ˹

<220>
<223>  ˹

<400>  18
gagatcgtcc tgacacagag tcctgctacc ctgagcgctt ccccaggaga gagggcaacc     60

atctcctgcc gcgcctctca gagcgttagc tcctggctgg cttggtacca gcagaagcca    120

ggccaggcac cccgaagcct gatctatgcc gcttctaatc tgcagagcgg gattcccgct    180

agattctctg gcagtgggtc aggaacagac tttaccctga caatctcaag cctggagcct    240

gaagatttcg ccgtgtacta ttgccagcag tacaacatct acccatttac atttggccag    300

gggactcggc tggagatcaa g                                              321


<210>  19
<211>  6
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  19

Gln Ser Val Gly Ser Trp 
1               5       


<210>  20
<211>  6
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  20

Gln Ser Val Ser Ser Trp 
1               5       


<210>  21
<211>  3
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  21

Ala Ser Asn 
1           


<210>  22
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  22

Gln Gln Tyr Asn Ile Tyr Pro Tyr Thr 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  23

Gln Gln Tyr Asn Ile Tyr Pro Phe Thr 
1               5                   


<210>  24
<211>  119
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  24

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ser Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Met Ser Pro Val Asp Ser Asp Ile Arg Tyr Asn Pro Met Phe 
    50                  55                  60                  


Arg Gly Gln Val Thr Met Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Pro Gly Gln Gly Tyr Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  25
<211>  107
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  25

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Gly Thr Trp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  26
<211>  8
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  26

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  27
<211>  6
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  27

Gln Ser Val Gly Thr Trp 
1               5       


<210>  28
<211>  3
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  28

Ala Ala Ser 
1           


<210>  29
<211>  25
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  29

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ser Ser 
            20                  25  


<210>  30
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  30

Ile Gly Trp Val Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Ile 
    


<210>  31
<211>  38
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  31

Arg Tyr Asn Pro Met Phe Arg Gly Gln Val Thr Met Ser Val Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp 
            20                  25                  30          


Thr Ala Met Tyr Tyr Cys 
        35              


<210>  32
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  32

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  33
<211>  26
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  33

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser 
            20                  25      


<210>  34
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  34

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ser Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  35
<211>  36
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  35

Asn Leu Gln Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
            20                  25                  30          


Val Tyr Tyr Cys 
        35      


<210>  36
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  36

Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
1               5                   10  


<210>  37
<211>  357
<212>  DNA
<213>  ˹

<220>
<223>  ˹

<400>  37
gaggtgcagc tggtgcagtc tggggccgaa gtgaagaaac ccggggagag tctgaagatc     60

tcatgccaga gctccggcta caccttcacc tcatattgga tcgggtgggt gagacagatg    120

cctggccagg ggctggaatg gatcggaatt atgagcccag tggactccga tattcgctac    180

aaccccatgt ttcgaggcca ggtgacaatg agcgtggaca agtctagttc aactgcttat    240

ctgcagtgga gctccctgaa agccagcgat accgctatgt actattgtgc ccggagaagg    300

cctggacagg gctacttcga cttttggggg cagggaacta tggtgaccgt ctctagt       357


<210>  38
<211>  321
<212>  DNA
<213>  ˹

<220>
<223>  ˹

<400>  38
gagatcgtcc tgacacagag tcctgctacc ctgagcgctt ccccaggaga gagggcaacc     60

atctcctgcc gcgcctctca gagcgttggc acctgggtgg cttggtacca gcagaagcca    120

ggccaggcac cccgaagcct gatctatgcc gcttctaatc tgcagagcgg gattcccgct    180

agattctctg gcagtgggtc aggaacagac tttaccctga caatctcaag cctggagcct    240

gaagatttcg ccgtgtacta ttgccagcag tacaacatct acccatatac atttggccag    300

gggactcggc tggagatcaa g                                              321


<210>  39
<211>  449
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  39

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ser Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Met Ser Pro Val Asp Ser Asp Ile Arg Tyr Asn Pro Met Phe 
    50                  55                  60                  


Arg Gly Gln Val Thr Met Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Pro Gly Gln Gly Tyr Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  40
<211>  214
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  40

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Gly Thr Trp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  41
<211>  26
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  41

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
            20                  25      


<210>  42
<211>  18
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  42

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
1               5                   10                  15      


Tyr Ser 
        


<210>  43
<211>  35
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  43

Arg Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
1               5                   10                  15      


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            20                  25                  30          


Tyr Tyr Cys 
        35  


<210>  44
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  44

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  45
<211>  18
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  45

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ser Leu Ile 
1               5                   10                  15      


Tyr Ala 
        


<210>  46
<211>  35
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  46

Leu Gln Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
1               5                   10                  15      


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
            20                  25                  30          


Tyr Tyr Cys 
        35  


<210>  47
<211>  18
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  47

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ser Leu Ile 
1               5                   10                  15      


Tyr Ser 
        


<210>  48
<211>  35
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  48

Arg Gln Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
1               5                   10                  15      


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
            20                  25                  30          


Tyr Tyr Cys 
        35  


<210>  49
<211>  449
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  49

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Ser Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Met Ser Pro Val Asp Ser Asp Ile Arg Tyr Asn Pro Met Phe 
    50                  55                  60                  


Arg Gly Gln Val Thr Met Ser Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Pro Gly Gln Gly Tyr Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  50
<211>  214
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  50

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Arg Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ile Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  51
<211>  214
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  51

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  52
<211>  214
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  52

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ser Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Leu Gln Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  53
<211>  214
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  53

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Arg Gln Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  54
<211>  214
<212>  PRT
<213>  ˹

<220>
<223>  ˹

<400>  54

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


