                         SEQUENCE LISTING

<110>  ѧ
 
<120>  һڵϸChIP-seqĿƱںϵ׼Ӧ

<130>  OWO20016766

<150>  CN2019107099330
<151>  2019-08-01

<160>  7     

<170>  PatentIn version 3.3

<210>  1
<211>  476
<212>  PRT
<213>  ˹

<400>  1

Met Ile Thr Ser Ala Leu His Arg Ala Ala Asp Trp Ala Lys Ser Val 
1               5                   10                  15      


Phe Ser Ser Ala Ala Leu Gly Asp Pro Arg Arg Thr Ala Arg Leu Val 
            20                  25                  30          


Asn Val Ala Ala Gln Leu Ala Lys Tyr Ser Gly Lys Ser Ile Thr Ile 
        35                  40                  45              


Ser Ser Glu Gly Ser Glu Ala Met Gln Glu Gly Ala Tyr Arg Phe Ile 
    50                  55                  60                  


Arg Asn Pro Asn Val Ser Ala Glu Ala Ile Arg Lys Ala Gly Ala Met 
65                  70                  75                  80  


Gln Thr Val Lys Leu Ala Gln Glu Phe Pro Glu Leu Leu Ala Ile Glu 
                85                  90                  95      


Asp Thr Thr Ser Leu Ser Tyr Arg His Gln Val Ala Glu Glu Leu Gly 
            100                 105                 110         


Lys Leu Gly Ser Ile Gln Asp Lys Ser Arg Gly Trp Trp Val His Ser 
        115                 120                 125             


Val Leu Leu Leu Glu Ala Thr Thr Phe Arg Thr Val Gly Leu Leu His 
    130                 135                 140                 


Gln Glu Trp Trp Met Arg Pro Asp Asp Pro Ala Asp Ala Asp Glu Lys 
145                 150                 155                 160 


Glu Ser Gly Lys Trp Leu Ala Ala Ala Ala Thr Ser Arg Leu Arg Met 
                165                 170                 175     


Gly Ser Met Met Ser Asn Val Ile Ala Val Cys Asp Arg Glu Ala Asp 
            180                 185                 190         


Ile His Ala Tyr Leu Gln Asp Lys Leu Ala His Asn Glu Arg Phe Val 
        195                 200                 205             


Val Arg Ser Lys His Pro Arg Lys Asp Val Glu Ser Gly Leu Tyr Leu 
    210                 215                 220                 


Tyr Asp His Leu Lys Asn Gln Pro Glu Leu Gly Gly Tyr Gln Ile Ser 
225                 230                 235                 240 


Ile Pro Gln Lys Gly Val Val Asp Lys Arg Gly Lys Arg Lys Asn Arg 
                245                 250                 255     


Pro Ala Arg Lys Ala Ser Leu Ser Leu Arg Ser Gly Arg Ile Thr Leu 
            260                 265                 270         


Lys Gln Gly Asn Ile Thr Leu Asn Ala Val Leu Ala Glu Glu Ile Asn 
        275                 280                 285             


Pro Pro Lys Gly Glu Thr Pro Leu Lys Trp Leu Leu Leu Thr Ser Glu 
    290                 295                 300                 


Pro Val Glu Ser Leu Ala Gln Ala Leu Arg Val Ile Asp Ile Tyr Thr 
305                 310                 315                 320 


His Arg Trp Arg Ile Glu Glu Phe His Lys Ala Trp Lys Thr Gly Ala 
                325                 330                 335     


Gly Ala Glu Arg Gln Arg Met Glu Glu Pro Asp Asn Leu Glu Arg Met 
            340                 345                 350         


Val Ser Ile Leu Ser Phe Val Ala Val Arg Leu Leu Gln Leu Arg Glu 
        355                 360                 365             


Ser Phe Thr Leu Pro Gln Ala Leu Arg Ala Gln Gly Leu Leu Lys Glu 
    370                 375                 380                 


Ala Glu His Val Glu Ser Gln Ser Ala Glu Thr Val Leu Thr Pro Asp 
385                 390                 395                 400 


Glu Cys Gln Leu Leu Gly Tyr Leu Asp Lys Gly Lys Arg Lys Arg Lys 
                405                 410                 415     


Glu Lys Ala Gly Ser Leu Gln Trp Ala Tyr Met Ala Ile Ala Arg Leu 
            420                 425                 430         


Gly Gly Phe Met Asp Ser Lys Arg Thr Gly Ile Ala Ser Trp Gly Ala 
        435                 440                 445             


Leu Trp Glu Gly Trp Glu Ala Leu Gln Ser Lys Leu Asp Gly Phe Leu 
    450                 455                 460                 


Ala Ala Lys Asp Leu Met Ala Gln Gly Ile Lys Ile 
465                 470                 475     


<210>  2
<211>  476
<212>  PRT
<213>  ˹

<400>  2

Met Ile Thr Ser Ala Leu His Arg Ala Ala Asp Trp Ala Lys Ser Val 
1               5                   10                  15      


Phe Ser Ser Ala Ala Leu Gly Asp Pro Arg Arg Thr Ala Arg Leu Val 
            20                  25                  30          


Asn Val Ala Ala Gln Leu Ala Lys Tyr Ser Gly Lys Ser Ile Thr Ile 
        35                  40                  45              


Ser Ser Glu Gly Ser Lys Ala Met Gln Glu Gly Ala Tyr Arg Phe Ile 
    50                  55                  60                  


Arg Asn Pro Asn Val Ser Ala Glu Ala Ile Arg Lys Ala Gly Ala Met 
65                  70                  75                  80  


Gln Thr Val Lys Leu Ala Gln Glu Phe Pro Glu Leu Leu Ala Ile Glu 
                85                  90                  95      


Asp Thr Thr Ser Leu Ser Tyr Arg His Gln Val Ala Glu Glu Leu Gly 
            100                 105                 110         


Lys Leu Gly Ser Ile Gln Asp Lys Ser Arg Gly Trp Trp Val His Ser 
        115                 120                 125             


Val Leu Leu Leu Glu Ala Thr Thr Phe Arg Thr Val Gly Leu Leu His 
    130                 135                 140                 


Gln Glu Trp Trp Met Arg Pro Asp Asp Pro Ala Asp Ala Asp Glu Lys 
145                 150                 155                 160 


Glu Ser Gly Lys Trp Leu Ala Ala Ala Ala Thr Ser Arg Leu Arg Met 
                165                 170                 175     


Gly Ser Met Met Ser Asn Val Ile Ala Val Cys Asp Arg Glu Ala Asp 
            180                 185                 190         


Ile His Ala Tyr Leu Gln Asp Lys Leu Ala His Asn Glu Arg Phe Val 
        195                 200                 205             


Val Arg Ser Lys His Pro Arg Lys Asp Val Glu Ser Gly Leu Tyr Leu 
    210                 215                 220                 


Tyr Asp His Leu Lys Asn Gln Pro Glu Leu Gly Gly Tyr Gln Ile Ser 
225                 230                 235                 240 


Ile Pro Gln Lys Gly Val Val Asp Lys Arg Gly Lys Arg Lys Asn Arg 
                245                 250                 255     


Pro Ala Arg Lys Ala Ser Leu Ser Leu Arg Ser Gly Arg Ile Thr Leu 
            260                 265                 270         


Lys Gln Gly Asn Ile Thr Leu Asn Ala Val Leu Ala Glu Glu Ile Asn 
        275                 280                 285             


Pro Pro Lys Gly Glu Thr Pro Leu Lys Trp Leu Leu Leu Thr Ser Glu 
    290                 295                 300                 


Pro Val Glu Ser Leu Ala Gln Ala Leu Arg Val Ile Asp Ile Tyr Thr 
305                 310                 315                 320 


His Arg Trp Arg Ile Glu Glu Phe His Lys Ala Trp Lys Thr Gly Ala 
                325                 330                 335     


Gly Ala Glu Arg Gln Arg Met Glu Glu Pro Asp Asn Leu Glu Arg Met 
            340                 345                 350         


Val Ser Ile Leu Ser Phe Val Ala Val Arg Leu Leu Gln Leu Arg Glu 
        355                 360                 365             


Ser Phe Thr Pro Pro Gln Ala Leu Arg Ala Gln Gly Leu Leu Lys Glu 
    370                 375                 380                 


Ala Glu His Val Glu Ser Gln Ser Ala Glu Thr Val Leu Thr Pro Asp 
385                 390                 395                 400 


Glu Cys Gln Leu Leu Gly Tyr Leu Asp Lys Gly Lys Arg Lys Arg Lys 
                405                 410                 415     


Glu Lys Ala Gly Ser Leu Gln Trp Ala Tyr Met Ala Ile Ala Arg Leu 
            420                 425                 430         


Gly Gly Phe Met Asp Ser Lys Arg Thr Gly Ile Ala Ser Trp Gly Ala 
        435                 440                 445             


Leu Trp Glu Gly Trp Glu Ala Leu Gln Ser Lys Leu Asp Gly Phe Leu 
    450                 455                 460                 


Ala Ala Lys Asp Leu Met Ala Gln Gly Ile Lys Ile 
465                 470                 475     


<210>  3
<211>  9
<212>  PRT
<213>  ˹

<400>  3

Gly Gly Ser Asp Asp Asp Lys Glu Phe 
1               5                   


<210>  4
<211>  611
<212>  PRT
<213>  ˹

<400>  4

Met Val Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu 
1               5                   10                  15      


Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Ala Phe Ile 
            20                  25                  30          


Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu 
        35                  40                  45              


Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Val Asp Asn Lys Phe 
    50                  55                  60                  


Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn 
65                  70                  75                  80  


Leu Asn Glu Glu Gln Arg Asn Ala Phe Ile Gln Ser Leu Lys Asp Asp 
                85                  90                  95      


Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Gly 
            100                 105                 110         


Ala Gln Ala Pro Lys Val Asp Ala Asn Ser Ala Gly Lys Ser Thr Gly 
        115                 120                 125             


Gly Ser Asp Asp Asp Lys Glu Phe Ile Thr Ser Ala Leu His Arg Ala 
    130                 135                 140                 


Ala Asp Trp Ala Lys Ser Val Phe Ser Ser Ala Ala Leu Gly Asp Pro 
145                 150                 155                 160 


Arg Arg Thr Ala Arg Leu Val Asn Val Ala Ala Gln Leu Ala Lys Tyr 
                165                 170                 175     


Ser Gly Lys Ser Ile Thr Ile Ser Ser Glu Gly Ser Lys Ala Met Gln 
            180                 185                 190         


Glu Gly Ala Tyr Arg Phe Ile Arg Asn Pro Asn Val Ser Ala Glu Ala 
        195                 200                 205             


Ile Arg Lys Ala Gly Ala Met Gln Thr Val Lys Leu Ala Gln Glu Phe 
    210                 215                 220                 


Pro Glu Leu Leu Ala Ile Glu Asp Thr Thr Ser Leu Ser Tyr Arg His 
225                 230                 235                 240 


Gln Val Ala Glu Glu Leu Gly Lys Leu Gly Ser Ile Gln Asp Lys Ser 
                245                 250                 255     


Arg Gly Trp Trp Val His Ser Val Leu Leu Leu Glu Ala Thr Thr Phe 
            260                 265                 270         


Arg Thr Val Gly Leu Leu His Gln Glu Trp Trp Met Arg Pro Asp Asp 
        275                 280                 285             


Pro Ala Asp Ala Asp Glu Lys Glu Ser Gly Lys Trp Leu Ala Ala Ala 
    290                 295                 300                 


Ala Thr Ser Arg Leu Arg Met Gly Ser Met Met Ser Asn Val Ile Ala 
305                 310                 315                 320 


Val Cys Asp Arg Glu Ala Asp Ile His Ala Tyr Leu Gln Asp Lys Leu 
                325                 330                 335     


Ala His Asn Glu Arg Phe Val Val Arg Ser Lys His Pro Arg Lys Asp 
            340                 345                 350         


Val Glu Ser Gly Leu Tyr Leu Tyr Asp His Leu Lys Asn Gln Pro Glu 
        355                 360                 365             


Leu Gly Gly Tyr Gln Ile Ser Ile Pro Gln Lys Gly Val Val Asp Lys 
    370                 375                 380                 


Arg Gly Lys Arg Lys Asn Arg Pro Ala Arg Lys Ala Ser Leu Ser Leu 
385                 390                 395                 400 


Arg Ser Gly Arg Ile Thr Leu Lys Gln Gly Asn Ile Thr Leu Asn Ala 
                405                 410                 415     


Val Leu Ala Glu Glu Ile Asn Pro Pro Lys Gly Glu Thr Pro Leu Lys 
            420                 425                 430         


Trp Leu Leu Leu Thr Ser Glu Pro Val Glu Ser Leu Ala Gln Ala Leu 
        435                 440                 445             


Arg Val Ile Asp Ile Tyr Thr His Arg Trp Arg Ile Glu Glu Phe His 
    450                 455                 460                 


Lys Ala Trp Lys Thr Gly Ala Gly Ala Glu Arg Gln Arg Met Glu Glu 
465                 470                 475                 480 


Pro Asp Asn Leu Glu Arg Met Val Ser Ile Leu Ser Phe Val Ala Val 
                485                 490                 495     


Arg Leu Leu Gln Leu Arg Glu Ser Phe Thr Pro Pro Gln Ala Leu Arg 
            500                 505                 510         


Ala Gln Gly Leu Leu Lys Glu Ala Glu His Val Glu Ser Gln Ser Ala 
        515                 520                 525             


Glu Thr Val Leu Thr Pro Asp Glu Cys Gln Leu Leu Gly Tyr Leu Asp 
    530                 535                 540                 


Lys Gly Lys Arg Lys Arg Lys Glu Lys Ala Gly Ser Leu Gln Trp Ala 
545                 550                 555                 560 


Tyr Met Ala Ile Ala Arg Leu Gly Gly Phe Met Asp Ser Lys Arg Thr 
                565                 570                 575     


Gly Ile Ala Ser Trp Gly Ala Leu Trp Glu Gly Trp Glu Ala Leu Gln 
            580                 585                 590         


Ser Lys Leu Asp Gly Phe Leu Ala Ala Lys Asp Leu Met Ala Gln Gly 
        595                 600                 605             


Ile Lys Ile 
    610     


<210>  5
<211>  702
<212>  PRT
<213>  ˹

<400>  5

Met Thr Met Ile Thr Pro Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala 
1               5                   10                  15      


Asn Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys 
            20                  25                  30          


Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile 
        35                  40                  45              


Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln 
    50                  55                  60                  


Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
65                  70                  75                  80  


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn 
                85                  90                  95      


Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu 
            100                 105                 110         


Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro 
        115                 120                 125             


Ser Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala 
    130                 135                 140                 


Gln Ala Pro Lys Thr Thr Tyr Lys Leu Val Ile Asn Gly Lys Thr Leu 
145                 150                 155                 160 


Lys Gly Glu Thr Thr Thr Glu Ala Val Asp Ala Glu Thr Ala Glu Arg 
                165                 170                 175     


His Phe Lys Gln Tyr Ala Asn Asp Asn Gly Val Asp Gly Glu Trp Thr 
            180                 185                 190         


Tyr Asp Asp Ala Thr Lys Thr Phe Thr Val Thr Glu Lys Pro Glu Val 
        195                 200                 205             


Ile Asp Ala Ser Glu Leu Thr Pro Ala Val Gly Gly Ser Asp Asp Asp 
    210                 215                 220                 


Lys Glu Phe Ile Thr Ser Ala Leu His Arg Ala Ala Asp Trp Ala Lys 
225                 230                 235                 240 


Ser Val Phe Ser Ser Ala Ala Leu Gly Asp Pro Arg Arg Thr Ala Arg 
                245                 250                 255     


Leu Val Asn Val Ala Ala Gln Leu Ala Lys Tyr Ser Gly Lys Ser Ile 
            260                 265                 270         


Thr Ile Ser Ser Glu Gly Ser Lys Ala Met Gln Glu Gly Ala Tyr Arg 
        275                 280                 285             


Phe Ile Arg Asn Pro Asn Val Ser Ala Glu Ala Ile Arg Lys Ala Gly 
    290                 295                 300                 


Ala Met Gln Thr Val Lys Leu Ala Gln Glu Phe Pro Glu Leu Leu Ala 
305                 310                 315                 320 


Ile Glu Asp Thr Thr Ser Leu Ser Tyr Arg His Gln Val Ala Glu Glu 
                325                 330                 335     


Leu Gly Lys Leu Gly Ser Ile Gln Asp Lys Ser Arg Gly Trp Trp Val 
            340                 345                 350         


His Ser Val Leu Leu Leu Glu Ala Thr Thr Phe Arg Thr Val Gly Leu 
        355                 360                 365             


Leu His Gln Glu Trp Trp Met Arg Pro Asp Asp Pro Ala Asp Ala Asp 
    370                 375                 380                 


Glu Lys Glu Ser Gly Lys Trp Leu Ala Ala Ala Ala Thr Ser Arg Leu 
385                 390                 395                 400 


Arg Met Gly Ser Met Met Ser Asn Val Ile Ala Val Cys Asp Arg Glu 
                405                 410                 415     


Ala Asp Ile His Ala Tyr Leu Gln Asp Lys Leu Ala His Asn Glu Arg 
            420                 425                 430         


Phe Val Val Arg Ser Lys His Pro Arg Lys Asp Val Glu Ser Gly Leu 
        435                 440                 445             


Tyr Leu Tyr Asp His Leu Lys Asn Gln Pro Glu Leu Gly Gly Tyr Gln 
    450                 455                 460                 


Ile Ser Ile Pro Gln Lys Gly Val Val Asp Lys Arg Gly Lys Arg Lys 
465                 470                 475                 480 


Asn Arg Pro Ala Arg Lys Ala Ser Leu Ser Leu Arg Ser Gly Arg Ile 
                485                 490                 495     


Thr Leu Lys Gln Gly Asn Ile Thr Leu Asn Ala Val Leu Ala Glu Glu 
            500                 505                 510         


Ile Asn Pro Pro Lys Gly Glu Thr Pro Leu Lys Trp Leu Leu Leu Thr 
        515                 520                 525             


Ser Glu Pro Val Glu Ser Leu Ala Gln Ala Leu Arg Val Ile Asp Ile 
    530                 535                 540                 


Tyr Thr His Arg Trp Arg Ile Glu Glu Phe His Lys Ala Trp Lys Thr 
545                 550                 555                 560 


Gly Ala Gly Ala Glu Arg Gln Arg Met Glu Glu Pro Asp Asn Leu Glu 
                565                 570                 575     


Arg Met Val Ser Ile Leu Ser Phe Val Ala Val Arg Leu Leu Gln Leu 
            580                 585                 590         


Arg Glu Ser Phe Thr Pro Pro Gln Ala Leu Arg Ala Gln Gly Leu Leu 
        595                 600                 605             


Lys Glu Ala Glu His Val Glu Ser Gln Ser Ala Glu Thr Val Leu Thr 
    610                 615                 620                 


Pro Asp Glu Cys Gln Leu Leu Gly Tyr Leu Asp Lys Gly Lys Arg Lys 
625                 630                 635                 640 


Arg Lys Glu Lys Ala Gly Ser Leu Gln Trp Ala Tyr Met Ala Ile Ala 
                645                 650                 655     


Arg Leu Gly Gly Phe Met Asp Ser Lys Arg Thr Gly Ile Ala Ser Trp 
            660                 665                 670         


Gly Ala Leu Trp Glu Gly Trp Glu Ala Leu Gln Ser Lys Leu Asp Gly 
        675                 680                 685             


Phe Leu Ala Ala Lys Asp Leu Met Ala Gln Gly Ile Lys Ile 
    690                 695                 700         


<210>  6
<211>  54
<212>  DNA
<213>  ˹

<400>  6
acactctttc cctacacgac gctcttccga tcttcgtcgg cagcgtctcc acgc           54


<210>  7
<211>  57
<212>  DNA
<213>  ˹

<400>  7
gactggagtt cagacgtgtg ctcttccgat ctgtctcgtg ggctcggctg tccctgt        57


