                         SEQUENCE LISTING

<110>  THE HOSPITAL FOR SICK CHILDREN
       THE GOVERNING  COUNCIL OF THE UNIVERSTIY OF TORONTO
 
<120>  MULTI-VALENT AND MULTI-SPECIFIC NANOPARTICLE PLATFORMS AND 
       METHODS

<130>  3206-5028 (158410) ELL

<140>  PCT/CA2020/051061
<141>  2020-07-31

<150>  62/881899
<151>  2019-08-01

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  1

Gly Gly Ser Ser Gly Ser Gly Ser Gly Ser Thr Gly Thr Ser Ser Ser 
1               5                   10                  15      


Gly Thr Gly Thr Ser Ala Gly Thr Thr Gly Thr Ser Ala Ser Thr Ser 
            20                  25                  30          


Gly Ser Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
        35                  40                  45              


Gly Gly Thr Ala Thr Ala Gly Ala Ser Ser Gly Ser Gly Ser Ser Gly 
    50                  55                  60                  


Ser Ser Ser Ser Gly Gly Thr Gly 
65                  70          


<210>  2
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu 
        195                 200                 205             


His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  3
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu 
        195                 200                 205             


His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  4
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ibalizumab-A12P light chain

<400>  4

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Thr Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  5
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ibalizumab-A12P heavy chain

<400>  5

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Asp Tyr Asp Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Asp Asn Tyr Ala Thr Gly Ala Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 


Gly Ser Arg 
225         


<210>  6
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10E8.v4 light ch

<400>  6

Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Lys Gln Thr 
1               5                   10                  15      


Val Thr Ile Thr Cys Arg Gly Asp Ser Leu Arg Ser His Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Lys Lys Pro Gly Gln Ala Pro Val Leu Leu Phe Tyr Gly 
        35                  40                  45              


Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ala 
    50                  55                  60                  


Ser Gly Asn Arg Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Lys Ser Gly Ser Arg Leu 
                85                  90                  95      


Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys 
    210             


<210>  7
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10E8.v4 heavy chain

<400>  7

Glu Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Asp Asn Ala 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Thr Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Glu Met Asn Asn Val Arg Thr Glu Asp Thr Gly Tyr Tyr 
                85                  90                  95      


Phe Cys Ala Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Ser Gly Tyr Pro 
            100                 105                 110         


Pro Gly Glu Glu Tyr Phe Gln Asp Trp Gly Gln Gly Thr Leu Val Ile 
        115                 120                 125             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
        195                 200                 205             


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Ser 
225                 230                 235 


<210>  8
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N49P7 light chain

<400>  8

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His Gln Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys 
        195                 200                 


<210>  9
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N49P7 heavy chain

<400>  9

Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys Pro Gly Asp Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe Pro Asp Tyr Ile 
            20                  25                  30          


Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Pro Glu Trp Met Gly 
        35                  40                  45              


Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro Trp Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Asp Arg 
                85                  90                  95      


Ser Asn Gly Ser Gly Lys Arg Phe Glu Ser Ser Asn Trp Phe Leu Asp 
            100                 105                 110         


Leu Trp Gly Arg Gly Thr Ala Val Thr Ile Gln Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Ser Arg 
225                 230 


<210>  10
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGDM1400 light chain

<400>  10

Asp Phe Val Leu Thr Gln Ser Pro His Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Ala Ser Ile Ser Cys Lys Ser Ser His Ser Leu Ile His Gly 
            20                  25                  30          


Asp Arg Asn Asn Tyr Leu Ala Trp Tyr Val Gln Lys Pro Gly Arg Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Ala Ser Ser Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Asp Lys Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Thr Glu Asp Val Gly Thr Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Arg Glu Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  11
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGDM1400 heavy chain

<400>  11

Gln Ala Gln Leu Val Gln Ser Gly Pro Glu Val Arg Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Pro Gly Asn Thr Leu Lys Thr Tyr 
            20                  25                  30          


Asp Leu His Trp Val Arg Ser Val Pro Gly Gln Gly Leu Gln Trp Met 
        35                  40                  45              


Gly Trp Ile Ser His Glu Gly Asp Lys Lys Val Ile Val Glu Arg Phe 
    50                  55                  60                  


Lys Ala Lys Val Thr Ile Asp Trp Asp Arg Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Gly Leu Thr Ser Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ser Lys His Arg Leu Arg Asp Tyr Ala Leu Tyr Asp Asp 
            100                 105                 110         


Asp Gly Ala Leu Asn Trp Ala Val Asp Val Asp Tyr Leu Ser Asn Leu 
        115                 120                 125             


Glu Phe Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Ser Arg 
                245         


<210>  12
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala 
1               5                   10                  15      


Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
            20                  25                  30          


Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val 
        35                  40                  45              


Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu 
    50                  55                  60                  


Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln 
65                  70                  75                  80  


Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp 
                85                  90  


<210>  13
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  13

Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys 
1               5                   10                  15      


Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr 
            20                  25                  30          


Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu 
        35                  40                  45              


Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg 
    50                  55                  60                  


Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu 
65                  70                  75                  80  


Thr Leu Arg His Asp 
                85  


<210>  14
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  14

Ala Ser Thr Ala Ser Ser Ala Ser Ser Gly Gly Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            20                  25  


<210>  15
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  15

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly Ala 
1               5                   10                  15      


Ser Gly Gly Ser 
            20  


<210>  16
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PGDM1400-hFerr

<400>  16

Asp Phe Val Leu Thr Gln Ser Pro His Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Ala Ser Ile Ser Cys Lys Ser Ser His Ser Leu Ile His Gly 
            20                  25                  30          


Asp Arg Asn Asn Tyr Leu Ala Trp Tyr Val Gln Lys Pro Gly Arg Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Ala Ser Ser Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Asp Lys Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Thr Glu Asp Val Gly Thr Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Arg Glu Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Ser Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Ser Thr Gly Thr Ser Ser Ser Gly Thr Gly Thr Ser 
225                 230                 235                 240 


Ala Gly Thr Thr Gly Thr Ser Ala Ser Thr Ser Gly Ser Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gly Gly Thr Ala Thr 
            260                 265                 270         


Ala Gly Ala Ser Ser Gly Ser Gly Ser Ser Gly Ser Ser Ser Ser Gly 
        275                 280                 285             


Gly Thr Gly Gln Ala Gln Leu Val Gln Ser Gly Pro Glu Val Arg Lys 
    290                 295                 300                 


Pro Gly Thr Ser Val Lys Val Ser Cys Lys Ala Pro Gly Asn Thr Leu 
305                 310                 315                 320 


Lys Thr Tyr Asp Leu His Trp Val Arg Ser Val Pro Gly Gln Gly Leu 
                325                 330                 335     


Gln Trp Met Gly Trp Ile Ser His Glu Gly Asp Lys Lys Val Ile Val 
            340                 345                 350         


Glu Arg Phe Lys Ala Lys Val Thr Ile Asp Trp Asp Arg Ser Thr Asn 
        355                 360                 365             


Thr Ala Tyr Leu Gln Leu Ser Gly Leu Thr Ser Gly Asp Thr Ala Val 
    370                 375                 380                 


Tyr Tyr Cys Ala Lys Gly Ser Lys His Arg Leu Arg Asp Tyr Ala Leu 
385                 390                 395                 400 


Tyr Asp Asp Asp Gly Ala Leu Asn Trp Ala Val Asp Val Asp Tyr Leu 
                405                 410                 415     


Ser Asn Leu Glu Phe Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser 
            420                 425                 430         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
        435                 440                 445             


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    450                 455                 460                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
465                 470                 475                 480 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                485                 490                 495     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
            500                 505                 510         


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        515                 520                 525             


Lys Val Glu Pro Lys Ser Cys Asp Ser Arg Ala Ser Thr Ala Ser Ser 
    530                 535                 540                 


Ala Ser Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser 
545                 550                 555                 560 


Gly Gly Ser Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val 
                565                 570                 575     


Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr 
            580                 585                 590         


Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        595                 600                 605             


Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu 
    610                 615                 620                 


Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala 
625                 630                 635                 640 


Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr 
                645                 650                 655     


Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln 
            660                 665                 670         


Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His 
        675                 680                 685             


Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu 
    690                 695                 700                 


Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly 
705                 710                 715                 720 


Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr Leu Arg 
                725                 730                 735     


His Asp Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            740                 745                 750         


Gly Ala Ser Gly Gly Ser 
        755             


<210>  17
<211>  643
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-N-hFerr LS

<400>  17

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu 
        195                 200                 205             


His Glu Ala Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Ser Ser Gly Ser Gly Ser Gly Ser Thr Gly Thr 
225                 230                 235                 240 


Ser Ser Ser Gly Thr Gly Thr Ser Ala Gly Thr Thr Gly Thr Ser Ala 
                245                 250                 255     


Ser Thr Ser Gly Ser Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Ala Gly Gly Thr Ala Thr Ala Gly Ala Ser Ser Gly Ser Gly 
        275                 280                 285             


Ser Ser Gly Ser Ser Ser Ser Gly Gly Thr Gly Asp Lys Thr His Thr 
    290                 295                 300                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
305                 310                 315                 320 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                325                 330                 335     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            340                 345                 350         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        355                 360                 365             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    370                 375                 380                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
385                 390                 395                 400 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                405                 410                 415     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            420                 425                 430         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        435                 440                 445             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    450                 455                 460                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
465                 470                 475                 480 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                485                 490                 495     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His 
            500                 505                 510         


Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Arg 
        515                 520                 525             


Ala Ser Thr Ala Ser Ser Ala Ser Ser Gly Gly Gly Gly Gly Gly Ser 
    530                 535                 540                 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Met Ser Ser Gln Ile Arg Gln 
545                 550                 555                 560 


Asn Tyr Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu 
                565                 570                 575     


Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp 
            580                 585                 590         


Arg Asp Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu 
        595                 600                 605             


Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn 
    610                 615                 620                 


Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu 
625                 630                 635                 640 


Asp Glu Trp 
            


<210>  18
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N49P7-C-hFerr

<400>  18

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Ala Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr His Asn Leu Val Ser Trp Cys 
            20                  25                  30          


Gln His Gln Pro Gly Arg Ala Pro Lys Leu Leu Ile Tyr Asp Phe Asn 
        35                  40                  45              


Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Gly Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln Asp Asp Asp Asp Ala 
65                  70                  75                  80  


Glu Tyr Phe Cys Trp Ala Tyr Glu Ala Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro 
            100                 105                 110         


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
        115                 120                 125             


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
    130                 135                 140                 


Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln 
145                 150                 155                 160 


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
                165                 170                 175     


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
            180                 185                 190         


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Gly Gly Ser Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Ser Thr Gly Thr Ser Ser Ser Gly Thr Gly Thr 
    210                 215                 220                 


Ser Ala Gly Thr Thr Gly Thr Ser Ala Ser Thr Ser Gly Ser Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gly Gly Thr Ala 
                245                 250                 255     


Thr Ala Gly Ala Ser Ser Gly Ser Gly Ser Ser Gly Ser Ser Ser Ser 
            260                 265                 270         


Gly Gly Thr Gly Ala Asp Leu Val Gln Ser Gly Ala Val Val Lys Lys 
        275                 280                 285             


Pro Gly Asp Ser Val Arg Ile Ser Cys Glu Ala Gln Gly Tyr Arg Phe 
    290                 295                 300                 


Pro Asp Tyr Ile Ile His Trp Ile Arg Arg Ala Pro Gly Gln Gly Pro 
305                 310                 315                 320 


Glu Trp Met Gly Trp Met Asn Pro Met Gly Gly Gln Val Asn Ile Pro 
                325                 330                 335     


Trp Lys Phe Gln Gly Arg Val Ser Met Thr Arg Asp Thr Ser Ile Glu 
            340                 345                 350         


Thr Ala Phe Leu Asp Leu Arg Gly Leu Lys Ser Asp Asp Thr Ala Val 
        355                 360                 365             


Tyr Tyr Cys Val Arg Asp Arg Ser Asn Gly Ser Gly Lys Arg Phe Glu 
    370                 375                 380                 


Ser Ser Asn Trp Phe Leu Asp Leu Trp Gly Arg Gly Thr Ala Val Thr 
385                 390                 395                 400 


Ile Gln Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
                405                 410                 415     


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
            420                 425                 430         


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
        435                 440                 445             


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
    450                 455                 460                 


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
465                 470                 475                 480 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
                485                 490                 495     


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Ser Arg Ala Ser Thr 
            500                 505                 510         


Ala Ser Ser Ala Ser Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Ser 
        515                 520                 525             


Gly Gly Ser Gly Gly Ser Gly Lys Thr Pro Asp Ala Met Lys Ala Ala 
    530                 535                 540                 


Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala 
545                 550                 555                 560 


Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr 
                565                 570                 575     


His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met Gly Asp His 
            580                 585                 590         


Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu 
        595                 600                 605             


Tyr Leu Phe Glu Arg Leu Thr Leu Arg His Asp Gly Gly Ser Gly Gly 
    610                 615                 620                 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly Ala Ser Gly Gly Ser 
625                 630                 635                 


<210>  19
<211>  648
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ibalizumab-A12P-C-hFerr

<400>  19

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Thr Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Ser Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Ser Thr Gly Thr Ser Ser Ser Gly Thr Gly Thr Ser 
225                 230                 235                 240 


Ala Gly Thr Thr Gly Thr Ser Ala Ser Thr Ser Gly Ser Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gly Gly Thr Ala Thr 
            260                 265                 270         


Ala Gly Ala Ser Ser Gly Ser Gly Ser Ser Gly Ser Ser Ser Ser Gly 
        275                 280                 285             


Gly Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys 
    290                 295                 300                 


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
305                 310                 315                 320 


Thr Ser Tyr Val Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu 
                325                 330                 335     


Asp Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Asp Tyr Asp 
            340                 345                 350         


Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Thr Ser 
        355                 360                 365             


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
    370                 375                 380                 


Tyr Tyr Cys Ala Arg Glu Lys Asp Asn Tyr Ala Thr Gly Ala Trp Phe 
385                 390                 395                 400 


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
                405                 410                 415     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
            420                 425                 430         


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        435                 440                 445             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    450                 455                 460                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
465                 470                 475                 480 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
                485                 490                 495     


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
            500                 505                 510         


Ser Lys Tyr Gly Ser Arg Ala Ser Thr Ala Ser Ser Ala Ser Ser Gly 
        515                 520                 525             


Gly Gly Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    530                 535                 540                 


Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu 
545                 550                 555                 560 


Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp 
                565                 570                 575     


Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val 
            580                 585                 590         


Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg Leu 
        595                 600                 605             


Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr 
    610                 615                 620                 


Leu Arg His Asp Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
625                 630                 635                 640 


Gly Gly Gly Ala Ser Gly Gly Ser 
                645             


<210>  20
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10E8.v4-C-hFerr

<400>  20

Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Lys Gln Thr 
1               5                   10                  15      


Val Thr Ile Thr Cys Arg Gly Asp Ser Leu Arg Ser His Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Lys Lys Pro Gly Gln Ala Pro Val Leu Leu Phe Tyr Gly 
        35                  40                  45              


Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ala 
    50                  55                  60                  


Ser Gly Asn Arg Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Lys Ser Gly Ser Arg Leu 
                85                  90                  95      


Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Gly Gly Ser Ser Gly Ser Gly Ser Gly Ser Thr 
    210                 215                 220                 


Gly Thr Ser Ser Ser Gly Thr Gly Thr Ser Ala Gly Thr Thr Gly Thr 
225                 230                 235                 240 


Ser Ala Ser Thr Ser Gly Ser Gly Ser Gly Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Ala Gly Gly Thr Ala Thr Ala Gly Ala Ser Ser Gly 
            260                 265                 270         


Ser Gly Ser Ser Gly Ser Ser Ser Ser Gly Gly Thr Gly Glu Val Arg 
        275                 280                 285             


Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg 
    290                 295                 300                 


Leu Ser Cys Ser Ala Ser Gly Phe Asp Phe Asp Asn Ala Trp Met Thr 
305                 310                 315                 320 


Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val Gly Arg Ile 
                325                 330                 335     


Thr Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Glu Ser Val Lys 
            340                 345                 350         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr Leu 
        355                 360                 365             


Glu Met Asn Asn Val Arg Thr Glu Asp Thr Gly Tyr Tyr Phe Cys Ala 
    370                 375                 380                 


Arg Thr Gly Lys Tyr Tyr Asp Phe Trp Ser Gly Tyr Pro Pro Gly Glu 
385                 390                 395                 400 


Glu Tyr Phe Gln Asp Trp Gly Gln Gly Thr Leu Val Ile Val Ser Ser 
                405                 410                 415     


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
            420                 425                 430         


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
        435                 440                 445             


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
    450                 455                 460                 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
465                 470                 475                 480 


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
                485                 490                 495     


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
            500                 505                 510         


Lys Val Glu Pro Lys Ser Cys Ser Arg Ala Ser Thr Ala Ser Ser Ala 
        515                 520                 525             


Ser Ser Gly Gly Gly Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    530                 535                 540                 


Gly Ser Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu 
545                 550                 555                 560 


Lys Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala 
                565                 570                 575     


Arg Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp 
            580                 585                 590         


Glu Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu 
        595                 600                 605             


His Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu 
    610                 615                 620                 


Arg Leu Thr Leu Arg His Asp Gly Gly Ser Gly Gly Ser Gly Gly Ser 
625                 630                 635                 640 


Gly Gly Ser Gly Gly Gly Ala Ser Gly Gly Ser 
                645                 650     


<210>  21
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFab 10E8

<400>  21

Tyr Glu Leu Thr Gln Glu Thr Gly Val Ser Val Ala Leu Gly Arg Thr 
1               5                   10                  15      


Val Thr Ile Thr Cys Arg Gly Asp Ser Leu Arg Ser His Tyr Ala Ser 
            20                  25                  30          


Trp Tyr Gln Lys Lys Pro Gly Gln Ala Pro Ile Leu Leu Phe Tyr Gly 
        35                  40                  45              


Lys Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ala 
    50                  55                  60                  


Ser Gly Asn Arg Ala Ser Leu Thr Ile Ser Gly Ala Gln Ala Glu Asp 
65                  70                  75                  80  


Asp Ala Glu Tyr Tyr Cys Ser Ser Arg Asp Lys Ser Gly Ser Arg Leu 
                85                  90                  95      


Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Gly Gly Ser Ser Gly Ser Gly Ser Gly Ser Thr 
    210                 215                 220                 


Gly Glu Asn Leu Tyr Phe Gln Gly Ser Ala Gly Thr Thr Gly Thr Ser 
225                 230                 235                 240 


Ala Ser Thr Ser Gly Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Gly 
                245                 250                 255     


Gly Gly Ser Ala Gly Gly Thr Ala Thr Leu Glu Val Leu Phe Gln Gly 
            260                 265                 270         


Pro Ser Ser Gly Ser Ser Ser Ser Gly Gly Thr Gly Glu Val Gln Leu 
        275                 280                 285             


Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Leu 
    290                 295                 300                 


Ser Cys Ser Ala Ser Gly Phe Asp Phe Asp Asn Ala Trp Met Thr Trp 
305                 310                 315                 320 


Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Val Gly Arg Ile Thr 
                325                 330                 335     


Gly Pro Gly Glu Gly Trp Ser Val Asp Tyr Ala Ala Pro Val Glu Gly 
            340                 345                 350         


Arg Phe Thr Ile Ser Arg Leu Asn Ser Ile Asn Phe Leu Tyr Leu Glu 
        355                 360                 365             


Met Asn Asn Leu Arg Met Glu Asp Ser Gly Leu Tyr Phe Cys Ala Arg 
    370                 375                 380                 


Thr Gly Lys Tyr Tyr Asp Phe Trp Ser Gly Tyr Pro Pro Gly Glu Glu 
385                 390                 395                 400 


Tyr Phe Gln Asp Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala 
                405                 410                 415     


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
            420                 425                 430         


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
        435                 440                 445             


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
    450                 455                 460                 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
465                 470                 475                 480 


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
                485                 490                 495     


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
            500                 505                 510         


Val Glu Pro Lys Ser Cys Ser Arg Gly Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Ser Gly Gly Ser Gly Gly Ser Met Ser Ser Gln Ile Arg Gln Asn Tyr 
    530                 535                 540                 


Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu 
545                 550                 555                 560 


Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp 
                565                 570                 575     


Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu 
            580                 585                 590         


Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg 
        595                 600                 605             


Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu 
    610                 615                 620                 


Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys 
625                 630                 635                 640 


Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg 
                645                 650                 655     


Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu 
            660                 665                 670         


Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His 
        675                 680                 685             


Arg Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg 
    690                 695                 700                 


Leu Thr Leu Arg His Asp 
705                 710 


