                         SEQUENCE LISTING

<110>  DUKE UNIVERSITY
 
<120>  COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF 
       ALZHEIMER'S DISEASE

<130>  028193-9332-WO01

<150>  62/878,230
<151>  2019-07-24

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  1491
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1491)

<400>  1
atg gcc tcg agc aca ggt gac cgg agc cag gcg gtg agg cat gga ctg         48
Met Ala Ser Ser Thr Gly Asp Arg Ser Gln Ala Val Arg His Gly Leu           
1               5                   10                  15                

agg gcg aag gtg ctg acg ctg gac ggc atg aac ccg cgt gtg cgg aga         96
Arg Ala Lys Val Leu Thr Leu Asp Gly Met Asn Pro Arg Val Arg Arg           
            20                  25                  30                    

gtg gag tac gca gtg cgt ggc ccc ata gtg cag cga gcc ttg gag ctg        144
Val Glu Tyr Ala Val Arg Gly Pro Ile Val Gln Arg Ala Leu Glu Leu           
        35                  40                  45                        

gag cag gag ctg cgc cag ggt gtg aag aag cct ttc acc gag gtc atc        192
Glu Gln Glu Leu Arg Gln Gly Val Lys Lys Pro Phe Thr Glu Val Ile           
    50                  55                  60                            

cgt gcc aac atc ggg gac gca cag gct atg ggg cag agg ccc atc acc        240
Arg Ala Asn Ile Gly Asp Ala Gln Ala Met Gly Gln Arg Pro Ile Thr           
65                  70                  75                  80            

ttc ctg cgc cag gtc ttg gcc ctc tgt gtt aac cct gat ctt ctg agc        288
Phe Leu Arg Gln Val Leu Ala Leu Cys Val Asn Pro Asp Leu Leu Ser           
                85                  90                  95                

agc ccc aac ttc cct gac gat gcc aag aaa agg gcg gag cgc atc ttg        336
Ser Pro Asn Phe Pro Asp Asp Ala Lys Lys Arg Ala Glu Arg Ile Leu           
            100                 105                 110                   

cag gcg tgt ggg ggc cac agt ctg ggg gcc tac agc gtc agc tcc ggc        384
Gln Ala Cys Gly Gly His Ser Leu Gly Ala Tyr Ser Val Ser Ser Gly           
        115                 120                 125                       

atc cag ctg atc cgg gag gac gtg gcg cgg tac att gag agg cgt gac        432
Ile Gln Leu Ile Arg Glu Asp Val Ala Arg Tyr Ile Glu Arg Arg Asp           
    130                 135                 140                           

gga ggc atc cct gcg gac ccc aac aac gtc ttc ctg tcc aca ggg gcc        480
Gly Gly Ile Pro Ala Asp Pro Asn Asn Val Phe Leu Ser Thr Gly Ala           
145                 150                 155                 160           

agc gat gcc atc gtg acg gtg ctg aag ctg ctg gtg gcc ggc gag ggc        528
Ser Asp Ala Ile Val Thr Val Leu Lys Leu Leu Val Ala Gly Glu Gly           
                165                 170                 175               

cac aca cgc acg ggt gtg ctc atc ccc atc ccc cag tac cca ctc tac        576
His Thr Arg Thr Gly Val Leu Ile Pro Ile Pro Gln Tyr Pro Leu Tyr           
            180                 185                 190                   

tcg gcc acg ctg gca gag ctg ggc gca gtg cag gtg gat tac tac ctg        624
Ser Ala Thr Leu Ala Glu Leu Gly Ala Val Gln Val Asp Tyr Tyr Leu           
        195                 200                 205                       

gac gag gag cgt gcc tgg gcg ctg gac gtg gcc gag ctt cac cgt gca        672
Asp Glu Glu Arg Ala Trp Ala Leu Asp Val Ala Glu Leu His Arg Ala           
    210                 215                 220                           

ctg ggc cag gcg cgt gac cac tgc cgc cct cgt gcg ctc tgt gtc atc        720
Leu Gly Gln Ala Arg Asp His Cys Arg Pro Arg Ala Leu Cys Val Ile           
225                 230                 235                 240           

aac cct ggc aac ccc acc ggg cag gtg cag acc cgc gag tgc atc gag        768
Asn Pro Gly Asn Pro Thr Gly Gln Val Gln Thr Arg Glu Cys Ile Glu           
                245                 250                 255               

gcc gtg atc cgc ttc gcc ttc gaa gag cgg ctc ttt ctg ctg gcg gac        816
Ala Val Ile Arg Phe Ala Phe Glu Glu Arg Leu Phe Leu Leu Ala Asp           
            260                 265                 270                   

gag gtg tac cag gac aac gtg tac gcc gcg ggt tcg cag ttc cac tca        864
Glu Val Tyr Gln Asp Asn Val Tyr Ala Ala Gly Ser Gln Phe His Ser           
        275                 280                 285                       

ttc aag aag gtg ctc atg gag atg ggg ccg ccc tac gcc ggg cag cag        912
Phe Lys Lys Val Leu Met Glu Met Gly Pro Pro Tyr Ala Gly Gln Gln           
    290                 295                 300                           

gag ctt gcc tcc ttc cac tcc acc tcc aag ggc tac atg ggc gag tgc        960
Glu Leu Ala Ser Phe His Ser Thr Ser Lys Gly Tyr Met Gly Glu Cys           
305                 310                 315                 320           

ggg ttc cgc ggc ggc tat gtg gag gtg gtg aac atg gac gct gca gtg       1008
Gly Phe Arg Gly Gly Tyr Val Glu Val Val Asn Met Asp Ala Ala Val           
                325                 330                 335               

cag cag cag atg ctg aag ctg atg agt gtg cgg ctg tgc ccg ccg gtg       1056
Gln Gln Gln Met Leu Lys Leu Met Ser Val Arg Leu Cys Pro Pro Val           
            340                 345                 350                   

cca gga cag gcc ctg ctg gac ctg gtg gtc agc ccg ccc gcg ccc acc       1104
Pro Gly Gln Ala Leu Leu Asp Leu Val Val Ser Pro Pro Ala Pro Thr           
        355                 360                 365                       

gac ccc tcc ttt gcg cag ttc cag gct gag aag cag gca gtg ctg gca       1152
Asp Pro Ser Phe Ala Gln Phe Gln Ala Glu Lys Gln Ala Val Leu Ala           
    370                 375                 380                           

gag ctg gcg gcc aag gcc aag ctc acc gag cag gtc ttc aat gag gct       1200
Glu Leu Ala Ala Lys Ala Lys Leu Thr Glu Gln Val Phe Asn Glu Ala           
385                 390                 395                 400           

cct ggc atc agc tgc aac cca gtg cag ggc gcc atg tac tcc ttc ccg       1248
Pro Gly Ile Ser Cys Asn Pro Val Gln Gly Ala Met Tyr Ser Phe Pro           
                405                 410                 415               

cgc gtg cag ctg ccc ccg cgg gcg gtg gag cgc gct cag gag ctg ggc       1296
Arg Val Gln Leu Pro Pro Arg Ala Val Glu Arg Ala Gln Glu Leu Gly           
            420                 425                 430                   

ctg gcc ccc gat atg ttc ttc tgc ctg cgc ctc ctg gag gag acc ggc       1344
Leu Ala Pro Asp Met Phe Phe Cys Leu Arg Leu Leu Glu Glu Thr Gly           
        435                 440                 445                       

atc tgc gtg gtg cca ggg agc ggc ttt ggg cag cgg gaa ggc acc tac       1392
Ile Cys Val Val Pro Gly Ser Gly Phe Gly Gln Arg Glu Gly Thr Tyr           
    450                 455                 460                           

cac ttc cgg atg acc att ctg ccc ccc ttg gag aaa ctg cgg ctg ctg       1440
His Phe Arg Met Thr Ile Leu Pro Pro Leu Glu Lys Leu Arg Leu Leu           
465                 470                 475                 480           

ctg gag aag ctg agc agg ttc cat gcc aag ttc acc ctc gag tac tcc       1488
Leu Glu Lys Leu Ser Arg Phe His Ala Lys Phe Thr Leu Glu Tyr Ser           
                485                 490                 495               

tga                                                                   1491


<210>  2
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ser Ser Thr Gly Asp Arg Ser Gln Ala Val Arg His Gly Leu 
1               5                   10                  15      


Arg Ala Lys Val Leu Thr Leu Asp Gly Met Asn Pro Arg Val Arg Arg 
            20                  25                  30          


Val Glu Tyr Ala Val Arg Gly Pro Ile Val Gln Arg Ala Leu Glu Leu 
        35                  40                  45              


Glu Gln Glu Leu Arg Gln Gly Val Lys Lys Pro Phe Thr Glu Val Ile 
    50                  55                  60                  


Arg Ala Asn Ile Gly Asp Ala Gln Ala Met Gly Gln Arg Pro Ile Thr 
65                  70                  75                  80  


Phe Leu Arg Gln Val Leu Ala Leu Cys Val Asn Pro Asp Leu Leu Ser 
                85                  90                  95      


Ser Pro Asn Phe Pro Asp Asp Ala Lys Lys Arg Ala Glu Arg Ile Leu 
            100                 105                 110         


Gln Ala Cys Gly Gly His Ser Leu Gly Ala Tyr Ser Val Ser Ser Gly 
        115                 120                 125             


Ile Gln Leu Ile Arg Glu Asp Val Ala Arg Tyr Ile Glu Arg Arg Asp 
    130                 135                 140                 


Gly Gly Ile Pro Ala Asp Pro Asn Asn Val Phe Leu Ser Thr Gly Ala 
145                 150                 155                 160 


Ser Asp Ala Ile Val Thr Val Leu Lys Leu Leu Val Ala Gly Glu Gly 
                165                 170                 175     


His Thr Arg Thr Gly Val Leu Ile Pro Ile Pro Gln Tyr Pro Leu Tyr 
            180                 185                 190         


Ser Ala Thr Leu Ala Glu Leu Gly Ala Val Gln Val Asp Tyr Tyr Leu 
        195                 200                 205             


Asp Glu Glu Arg Ala Trp Ala Leu Asp Val Ala Glu Leu His Arg Ala 
    210                 215                 220                 


Leu Gly Gln Ala Arg Asp His Cys Arg Pro Arg Ala Leu Cys Val Ile 
225                 230                 235                 240 


Asn Pro Gly Asn Pro Thr Gly Gln Val Gln Thr Arg Glu Cys Ile Glu 
                245                 250                 255     


Ala Val Ile Arg Phe Ala Phe Glu Glu Arg Leu Phe Leu Leu Ala Asp 
            260                 265                 270         


Glu Val Tyr Gln Asp Asn Val Tyr Ala Ala Gly Ser Gln Phe His Ser 
        275                 280                 285             


Phe Lys Lys Val Leu Met Glu Met Gly Pro Pro Tyr Ala Gly Gln Gln 
    290                 295                 300                 


Glu Leu Ala Ser Phe His Ser Thr Ser Lys Gly Tyr Met Gly Glu Cys 
305                 310                 315                 320 


Gly Phe Arg Gly Gly Tyr Val Glu Val Val Asn Met Asp Ala Ala Val 
                325                 330                 335     


Gln Gln Gln Met Leu Lys Leu Met Ser Val Arg Leu Cys Pro Pro Val 
            340                 345                 350         


Pro Gly Gln Ala Leu Leu Asp Leu Val Val Ser Pro Pro Ala Pro Thr 
        355                 360                 365             


Asp Pro Ser Phe Ala Gln Phe Gln Ala Glu Lys Gln Ala Val Leu Ala 
    370                 375                 380                 


Glu Leu Ala Ala Lys Ala Lys Leu Thr Glu Gln Val Phe Asn Glu Ala 
385                 390                 395                 400 


Pro Gly Ile Ser Cys Asn Pro Val Gln Gly Ala Met Tyr Ser Phe Pro 
                405                 410                 415     


Arg Val Gln Leu Pro Pro Arg Ala Val Glu Arg Ala Gln Glu Leu Gly 
            420                 425                 430         


Leu Ala Pro Asp Met Phe Phe Cys Leu Arg Leu Leu Glu Glu Thr Gly 
        435                 440                 445             


Ile Cys Val Val Pro Gly Ser Gly Phe Gly Gln Arg Glu Gly Thr Tyr 
    450                 455                 460                 


His Phe Arg Met Thr Ile Leu Pro Pro Leu Glu Lys Leu Arg Leu Leu 
465                 470                 475                 480 


Leu Glu Lys Leu Ser Arg Phe His Ala Lys Phe Thr Leu Glu Tyr Ser 
                485                 490                 495     


<210>  3
<211>  882
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(882)

<400>  3
atg gca cct ccg tca gtc ttt gcc gag gtt ccg cag gcc cag cct gtc         48
Met Ala Pro Pro Ser Val Phe Ala Glu Val Pro Gln Ala Gln Pro Val           
1               5                   10                  15                

ctg gtc ttc aag ctc act gcc gac ttc agg gag gat ccg gac ccc cgc         96
Leu Val Phe Lys Leu Thr Ala Asp Phe Arg Glu Asp Pro Asp Pro Arg           
            20                  25                  30                    

aag gtc aac ctg gga gtg gga gca tat cgc acg gat gac tgc cat ccc        144
Lys Val Asn Leu Gly Val Gly Ala Tyr Arg Thr Asp Asp Cys His Pro           
        35                  40                  45                        

tgg gtt ttg cca gta gtg aag aaa gtg gag cag aag att gct aat gac        192
Trp Val Leu Pro Val Val Lys Lys Val Glu Gln Lys Ile Ala Asn Asp           
    50                  55                  60                            

aat agc cta aat cac gag tat ctg cca atc ctg ggc ctg gct gag ttc        240
Asn Ser Leu Asn His Glu Tyr Leu Pro Ile Leu Gly Leu Ala Glu Phe           
65                  70                  75                  80            

cgg agc tgt gct tct cgt ctt gcc ctt ggg gat gac agc cca gca ctc        288
Arg Ser Cys Ala Ser Arg Leu Ala Leu Gly Asp Asp Ser Pro Ala Leu           
                85                  90                  95                

aag gag aag cgg gta gga ggt gtg caa tct ttg ggg gga aca ggt gca        336
Lys Glu Lys Arg Val Gly Gly Val Gln Ser Leu Gly Gly Thr Gly Ala           
            100                 105                 110                   

ctt cga att gga gct gat ttc tta gcg cgt tgg tac aat gga aca aac        384
Leu Arg Ile Gly Ala Asp Phe Leu Ala Arg Trp Tyr Asn Gly Thr Asn           
        115                 120                 125                       

aac aag aac aca cct gtc tat gtg tcc tca cca acc tgg gag aat cac        432
Asn Lys Asn Thr Pro Val Tyr Val Ser Ser Pro Thr Trp Glu Asn His           
    130                 135                 140                           

aat gct gtg ttt tcc gct gct ggt ttt aaa gac att cgg tcc tat cgc        480
Asn Ala Val Phe Ser Ala Ala Gly Phe Lys Asp Ile Arg Ser Tyr Arg           
145                 150                 155                 160           

tac tgg gat gca gag aag aga gga ttg gac ctc cag ggc ttc ctg aat        528
Tyr Trp Asp Ala Glu Lys Arg Gly Leu Asp Leu Gln Gly Phe Leu Asn           
                165                 170                 175               

gat ctg gag aat gct cct gag ttc tcc att gtt gtc ctc cac gcc tgt        576
Asp Leu Glu Asn Ala Pro Glu Phe Ser Ile Val Val Leu His Ala Cys           
            180                 185                 190                   

gca cac aac cca act ggg att gac cca act ccg gag cag tgg aag cag        624
Ala His Asn Pro Thr Gly Ile Asp Pro Thr Pro Glu Gln Trp Lys Gln           
        195                 200                 205                       

att gct tct gtc atg aag cac cgg ttt ctg ttc ccc ttc ttt gac tca        672
Ile Ala Ser Val Met Lys His Arg Phe Leu Phe Pro Phe Phe Asp Ser           
    210                 215                 220                           

gcc tat cag ggc ttc gca tct gga aac ctg gag aga gat gcc tgg gcc        720
Ala Tyr Gln Gly Phe Ala Ser Gly Asn Leu Glu Arg Asp Ala Trp Ala           
225                 230                 235                 240           

att cgc tat ttt gtg tct gaa ggc ttc gag ttc ttc tgt gcc cag tcc        768
Ile Arg Tyr Phe Val Ser Glu Gly Phe Glu Phe Phe Cys Ala Gln Ser           
                245                 250                 255               

ttc tcc aag aac ttc ggg ctc tac agt gag tgc tct cct gag gag tta        816
Phe Ser Lys Asn Phe Gly Leu Tyr Ser Glu Cys Ser Pro Glu Glu Leu           
            260                 265                 270                   

cag ccc cac ctc ctc gca tca ctc cct gct tca gca gcc aca gct gat        864
Gln Pro His Leu Leu Ala Ser Leu Pro Ala Ser Ala Ala Thr Ala Asp           
        275                 280                 285                       

tct ggt ccc tct ctt tag                                                882
Ser Gly Pro Ser Leu                                                       
    290                                                                   


<210>  4
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Pro Pro Ser Val Phe Ala Glu Val Pro Gln Ala Gln Pro Val 
1               5                   10                  15      


Leu Val Phe Lys Leu Thr Ala Asp Phe Arg Glu Asp Pro Asp Pro Arg 
            20                  25                  30          


Lys Val Asn Leu Gly Val Gly Ala Tyr Arg Thr Asp Asp Cys His Pro 
        35                  40                  45              


Trp Val Leu Pro Val Val Lys Lys Val Glu Gln Lys Ile Ala Asn Asp 
    50                  55                  60                  


Asn Ser Leu Asn His Glu Tyr Leu Pro Ile Leu Gly Leu Ala Glu Phe 
65                  70                  75                  80  


Arg Ser Cys Ala Ser Arg Leu Ala Leu Gly Asp Asp Ser Pro Ala Leu 
                85                  90                  95      


Lys Glu Lys Arg Val Gly Gly Val Gln Ser Leu Gly Gly Thr Gly Ala 
            100                 105                 110         


Leu Arg Ile Gly Ala Asp Phe Leu Ala Arg Trp Tyr Asn Gly Thr Asn 
        115                 120                 125             


Asn Lys Asn Thr Pro Val Tyr Val Ser Ser Pro Thr Trp Glu Asn His 
    130                 135                 140                 


Asn Ala Val Phe Ser Ala Ala Gly Phe Lys Asp Ile Arg Ser Tyr Arg 
145                 150                 155                 160 


Tyr Trp Asp Ala Glu Lys Arg Gly Leu Asp Leu Gln Gly Phe Leu Asn 
                165                 170                 175     


Asp Leu Glu Asn Ala Pro Glu Phe Ser Ile Val Val Leu His Ala Cys 
            180                 185                 190         


Ala His Asn Pro Thr Gly Ile Asp Pro Thr Pro Glu Gln Trp Lys Gln 
        195                 200                 205             


Ile Ala Ser Val Met Lys His Arg Phe Leu Phe Pro Phe Phe Asp Ser 
    210                 215                 220                 


Ala Tyr Gln Gly Phe Ala Ser Gly Asn Leu Glu Arg Asp Ala Trp Ala 
225                 230                 235                 240 


Ile Arg Tyr Phe Val Ser Glu Gly Phe Glu Phe Phe Cys Ala Gln Ser 
                245                 250                 255     


Phe Ser Lys Asn Phe Gly Leu Tyr Ser Glu Cys Ser Pro Glu Glu Leu 
            260                 265                 270         


Gln Pro His Leu Leu Ala Ser Leu Pro Ala Ser Ala Ala Thr Ala Asp 
        275                 280                 285             


Ser Gly Pro Ser Leu 
    290             


