                         SEQUENCE LISTING

<110>  H. LUNDBECK A/S
 
<120>  ANTI-MGLUR5 ANTIBODIES AND USES THEREOF

<130>  1143257.008213

<150>  62/701,989
<151>  2018-07-23

<150>  62/877,889
<151>  2019-07-24

<160>  469   

<170>  PatentIn version 3.5

<210>  1
<211>  1212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human mGluR5b

<400>  1

Met Val Leu Leu Leu Ile Leu Ser Val Leu Leu Leu Lys Glu Asp Val 
1               5                   10                  15      


Arg Gly Ser Ala Gln Ser Ser Glu Arg Arg Val Val Ala His Met Pro 
            20                  25                  30          


Gly Asp Ile Ile Ile Gly Ala Leu Phe Ser Val His His Gln Pro Thr 
        35                  40                  45              


Val Asp Lys Val His Glu Arg Lys Cys Gly Ala Val Arg Glu Gln Tyr 
    50                  55                  60                  


Gly Ile Gln Arg Val Glu Ala Met Leu His Thr Leu Glu Arg Ile Asn 
65                  70                  75                  80  


Ser Asp Pro Thr Leu Leu Pro Asn Ile Thr Leu Gly Cys Glu Ile Arg 
                85                  90                  95      


Asp Ser Cys Trp His Ser Ala Val Ala Leu Glu Gln Ser Ile Glu Phe 
            100                 105                 110         


Ile Arg Asp Ser Leu Ile Ser Ser Glu Glu Glu Glu Gly Leu Val Arg 
        115                 120                 125             


Cys Val Asp Gly Ser Ser Ser Ser Phe Arg Ser Lys Lys Pro Ile Val 
    130                 135                 140                 


Gly Val Ile Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn 
145                 150                 155                 160 


Leu Leu Gln Leu Phe Asn Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser 
                165                 170                 175     


Met Asp Leu Ser Asp Lys Thr Leu Phe Lys Tyr Phe Met Arg Val Val 
            180                 185                 190         


Pro Ser Asp Ala Gln Gln Ala Arg Ala Met Val Asp Ile Val Lys Arg 
        195                 200                 205             


Tyr Asn Trp Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly 
    210                 215                 220                 


Glu Ser Gly Met Glu Ala Phe Lys Asp Met Ser Ala Lys Glu Gly Ile 
225                 230                 235                 240 


Cys Ile Ala His Ser Tyr Lys Ile Tyr Ser Asn Ala Gly Glu Gln Ser 
                245                 250                 255     


Phe Asp Lys Leu Leu Lys Lys Leu Thr Ser His Leu Pro Lys Ala Arg 
            260                 265                 270         


Val Val Ala Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Met 
        275                 280                 285             


Ala Met Arg Arg Leu Gly Leu Ala Gly Glu Phe Leu Leu Leu Gly Ser 
    290                 295                 300                 


Asp Gly Trp Ala Asp Arg Tyr Asp Val Thr Asp Gly Tyr Gln Arg Glu 
305                 310                 315                 320 


Ala Val Gly Gly Ile Thr Ile Lys Leu Gln Ser Pro Asp Val Lys Trp 
                325                 330                 335     


Phe Asp Asp Tyr Tyr Leu Lys Leu Arg Pro Glu Thr Asn His Arg Asn 
            340                 345                 350         


Pro Trp Phe Gln Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Glu 
        355                 360                 365             


Gly Phe Pro Gln Glu Asn Ser Lys Tyr Asn Lys Thr Cys Asn Ser Ser 
    370                 375                 380                 


Leu Thr Leu Lys Thr His His Val Gln Asp Ser Lys Met Gly Phe Val 
385                 390                 395                 400 


Ile Asn Ala Ile Tyr Ser Met Ala Tyr Gly Leu His Asn Met Gln Met 
                405                 410                 415     


Ser Leu Cys Pro Gly Tyr Ala Gly Leu Cys Asp Ala Met Lys Pro Ile 
            420                 425                 430         


Asp Gly Arg Lys Leu Leu Glu Ser Leu Met Lys Thr Asn Phe Thr Gly 
        435                 440                 445             


Val Ser Gly Asp Thr Ile Leu Phe Asp Glu Asn Gly Asp Ser Pro Gly 
    450                 455                 460                 


Arg Tyr Glu Ile Met Asn Phe Lys Glu Met Gly Lys Asp Tyr Phe Asp 
465                 470                 475                 480 


Tyr Ile Asn Val Gly Ser Trp Asp Asn Gly Glu Leu Lys Met Asp Asp 
                485                 490                 495     


Asp Glu Val Trp Ser Lys Lys Ser Asn Ile Ile Arg Ser Val Cys Ser 
            500                 505                 510         


Glu Pro Cys Glu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val 
        515                 520                 525             


Ser Cys Cys Trp Thr Cys Thr Pro Cys Lys Glu Asn Glu Tyr Val Phe 
    530                 535                 540                 


Asp Glu Tyr Thr Cys Lys Ala Cys Gln Leu Gly Ser Trp Pro Thr Asp 
545                 550                 555                 560 


Asp Leu Thr Gly Cys Asp Leu Ile Pro Val Gln Tyr Leu Arg Trp Gly 
                565                 570                 575     


Asp Pro Glu Pro Ile Ala Ala Val Val Phe Ala Cys Leu Gly Leu Leu 
            580                 585                 590         


Ala Thr Leu Phe Val Thr Val Val Phe Ile Ile Tyr Arg Asp Thr Pro 
        595                 600                 605             


Val Val Lys Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly 
    610                 615                 620                 


Ile Cys Leu Gly Tyr Leu Cys Thr Phe Cys Leu Ile Ala Lys Pro Lys 
625                 630                 635                 640 


Gln Ile Tyr Cys Tyr Leu Gln Arg Ile Gly Ile Gly Leu Ser Pro Ala 
                645                 650                 655     


Met Ser Tyr Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile 
            660                 665                 670         


Leu Ala Gly Ser Lys Lys Lys Ile Cys Thr Lys Lys Pro Arg Phe Met 
        675                 680                 685             


Ser Ala Cys Ala Gln Leu Val Ile Ala Phe Ile Leu Ile Cys Ile Gln 
    690                 695                 700                 


Leu Gly Ile Ile Val Ala Leu Phe Ile Met Glu Pro Pro Asp Ile Met 
705                 710                 715                 720 


His Asp Tyr Pro Ser Ile Arg Glu Val Tyr Leu Ile Cys Asn Thr Thr 
                725                 730                 735     


Asn Leu Gly Val Val Thr Pro Leu Gly Tyr Asn Gly Leu Leu Ile Leu 
            740                 745                 750         


Ser Cys Thr Phe Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe 
        755                 760                 765             


Asn Glu Ala Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile 
    770                 775                 780                 


Trp Leu Ala Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile 
785                 790                 795                 800 


Thr Met Cys Phe Ser Val Ser Leu Ser Ala Thr Val Ala Leu Gly Cys 
                805                 810                 815     


Met Phe Val Pro Lys Val Tyr Ile Ile Leu Ala Lys Pro Glu Arg Asn 
            820                 825                 830         


Val Arg Ser Ala Phe Thr Thr Ser Thr Val Val Arg Met His Val Gly 
        835                 840                 845             


Asp Gly Lys Ser Ser Ser Ala Ala Ser Arg Ser Ser Ser Leu Val Asn 
    850                 855                 860                 


Leu Trp Lys Arg Arg Gly Ser Ser Gly Glu Thr Leu Arg Tyr Lys Asp 
865                 870                 875                 880 


Arg Arg Leu Ala Gln His Lys Ser Glu Ile Glu Cys Phe Thr Pro Lys 
                885                 890                 895     


Gly Ser Met Gly Asn Gly Gly Arg Ala Thr Met Ser Ser Ser Asn Gly 
            900                 905                 910         


Lys Ser Val Thr Trp Ala Gln Asn Glu Lys Ser Ser Arg Gly Gln His 
        915                 920                 925             


Leu Trp Gln Arg Leu Ser Ile His Ile Asn Lys Lys Glu Asn Pro Asn 
    930                 935                 940                 


Gln Thr Ala Val Ile Lys Pro Phe Pro Lys Ser Thr Glu Ser Arg Gly 
945                 950                 955                 960 


Leu Gly Ala Gly Ala Gly Ala Gly Gly Ser Ala Gly Gly Val Gly Ala 
                965                 970                 975     


Thr Gly Gly Ala Gly Cys Ala Gly Ala Gly Pro Gly Gly Pro Glu Ser 
            980                 985                 990         


Pro Asp Ala Gly Pro Lys Ala Leu  Tyr Asp Val Ala Glu  Ala Glu Glu 
        995                 1000                 1005             


His Phe  Pro Ala Pro Ala Arg  Pro Arg Ser Pro Ser  Pro Ile Ser 
    1010                 1015                 1020             


Thr Leu  Ser His Arg Ala Gly  Ser Ala Ser Arg Thr  Asp Asp Asp 
    1025                 1030                 1035             


Val Pro  Ser Leu His Ser Glu  Pro Val Ala Arg Ser  Ser Ser Ser 
    1040                 1045                 1050             


Gln Gly  Ser Leu Met Glu Gln  Ile Ser Ser Val Val  Thr Arg Phe 
    1055                 1060                 1065             


Thr Ala  Asn Ile Ser Glu Leu  Asn Ser Met Met Leu  Ser Thr Ala 
    1070                 1075                 1080             


Ala Pro  Ser Pro Gly Val Gly  Ala Pro Leu Cys Ser  Ser Tyr Leu 
    1085                 1090                 1095             


Ile Pro  Lys Glu Ile Gln Leu  Pro Thr Thr Met Thr  Thr Phe Ala 
    1100                 1105                 1110             


Glu Ile  Gln Pro Leu Pro Ala  Ile Glu Val Thr Gly  Gly Ala Gln 
    1115                 1120                 1125             


Pro Ala  Ala Gly Ala Gln Ala  Ala Gly Asp Ala Ala  Arg Glu Ser 
    1130                 1135                 1140             


Pro Ala  Ala Gly Pro Glu Ala  Ala Ala Ala Lys Pro  Asp Leu Glu 
    1145                 1150                 1155             


Glu Leu  Val Ala Leu Thr Pro  Pro Ser Pro Phe Arg  Asp Ser Val 
    1160                 1165                 1170             


Asp Ser  Gly Ser Thr Thr Pro  Asn Ser Pro Val Ser  Glu Ser Ala 
    1175                 1180                 1185             


Leu Cys  Ile Pro Ser Ser Pro  Lys Tyr Asp Thr Leu  Ile Ile Arg 
    1190                 1195                 1200             


Asp Tyr  Thr Gln Ser Ser Ser  Ser Leu 
    1205                 1210         


<210>  2
<211>  1180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human mGluR5a

<400>  2

Met Val Leu Leu Leu Ile Leu Ser Val Leu Leu Leu Lys Glu Asp Val 
1               5                   10                  15      


Arg Gly Ser Ala Gln Ser Ser Glu Arg Arg Val Val Ala His Met Pro 
            20                  25                  30          


Gly Asp Ile Ile Ile Gly Ala Leu Phe Ser Val His His Gln Pro Thr 
        35                  40                  45              


Val Asp Lys Val His Glu Arg Lys Cys Gly Ala Val Arg Glu Gln Tyr 
    50                  55                  60                  


Gly Ile Gln Arg Val Glu Ala Met Leu His Thr Leu Glu Arg Ile Asn 
65                  70                  75                  80  


Ser Asp Pro Thr Leu Leu Pro Asn Ile Thr Leu Gly Cys Glu Ile Arg 
                85                  90                  95      


Asp Ser Cys Trp His Ser Ala Val Ala Leu Glu Gln Ser Ile Glu Phe 
            100                 105                 110         


Ile Arg Asp Ser Leu Ile Ser Ser Glu Glu Glu Glu Gly Leu Val Arg 
        115                 120                 125             


Cys Val Asp Gly Ser Ser Ser Ser Phe Arg Ser Lys Lys Pro Ile Val 
    130                 135                 140                 


Gly Val Ile Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn 
145                 150                 155                 160 


Leu Leu Gln Leu Phe Asn Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser 
                165                 170                 175     


Met Asp Leu Ser Asp Lys Thr Leu Phe Lys Tyr Phe Met Arg Val Val 
            180                 185                 190         


Pro Ser Asp Ala Gln Gln Ala Arg Ala Met Val Asp Ile Val Lys Arg 
        195                 200                 205             


Tyr Asn Trp Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly 
    210                 215                 220                 


Glu Ser Gly Met Glu Ala Phe Lys Asp Met Ser Ala Lys Glu Gly Ile 
225                 230                 235                 240 


Cys Ile Ala His Ser Tyr Lys Ile Tyr Ser Asn Ala Gly Glu Gln Ser 
                245                 250                 255     


Phe Asp Lys Leu Leu Lys Lys Leu Thr Ser His Leu Pro Lys Ala Arg 
            260                 265                 270         


Val Val Ala Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Met 
        275                 280                 285             


Ala Met Arg Arg Leu Gly Leu Ala Gly Glu Phe Leu Leu Leu Gly Ser 
    290                 295                 300                 


Asp Gly Trp Ala Asp Arg Tyr Asp Val Thr Asp Gly Tyr Gln Arg Glu 
305                 310                 315                 320 


Ala Val Gly Gly Ile Thr Ile Lys Leu Gln Ser Pro Asp Val Lys Trp 
                325                 330                 335     


Phe Asp Asp Tyr Tyr Leu Lys Leu Arg Pro Glu Thr Asn His Arg Asn 
            340                 345                 350         


Pro Trp Phe Gln Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Glu 
        355                 360                 365             


Gly Phe Pro Gln Glu Asn Ser Lys Tyr Asn Lys Thr Cys Asn Ser Ser 
    370                 375                 380                 


Leu Thr Leu Lys Thr His His Val Gln Asp Ser Lys Met Gly Phe Val 
385                 390                 395                 400 


Ile Asn Ala Ile Tyr Ser Met Ala Tyr Gly Leu His Asn Met Gln Met 
                405                 410                 415     


Ser Leu Cys Pro Gly Tyr Ala Gly Leu Cys Asp Ala Met Lys Pro Ile 
            420                 425                 430         


Asp Gly Arg Lys Leu Leu Glu Ser Leu Met Lys Thr Asn Phe Thr Gly 
        435                 440                 445             


Val Ser Gly Asp Thr Ile Leu Phe Asp Glu Asn Gly Asp Ser Pro Gly 
    450                 455                 460                 


Arg Tyr Glu Ile Met Asn Phe Lys Glu Met Gly Lys Asp Tyr Phe Asp 
465                 470                 475                 480 


Tyr Ile Asn Val Gly Ser Trp Asp Asn Gly Glu Leu Lys Met Asp Asp 
                485                 490                 495     


Asp Glu Val Trp Ser Lys Lys Ser Asn Ile Ile Arg Ser Val Cys Ser 
            500                 505                 510         


Glu Pro Cys Glu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val 
        515                 520                 525             


Ser Cys Cys Trp Thr Cys Thr Pro Cys Lys Glu Asn Glu Tyr Val Phe 
    530                 535                 540                 


Asp Glu Tyr Thr Cys Lys Ala Cys Gln Leu Gly Ser Trp Pro Thr Asp 
545                 550                 555                 560 


Asp Leu Thr Gly Cys Asp Leu Ile Pro Val Gln Tyr Leu Arg Trp Gly 
                565                 570                 575     


Asp Pro Glu Pro Ile Ala Ala Val Val Phe Ala Cys Leu Gly Leu Leu 
            580                 585                 590         


Ala Thr Leu Phe Val Thr Val Val Phe Ile Ile Tyr Arg Asp Thr Pro 
        595                 600                 605             


Val Val Lys Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly 
    610                 615                 620                 


Ile Cys Leu Gly Tyr Leu Cys Thr Phe Cys Leu Ile Ala Lys Pro Lys 
625                 630                 635                 640 


Gln Ile Tyr Cys Tyr Leu Gln Arg Ile Gly Ile Gly Leu Ser Pro Ala 
                645                 650                 655     


Met Ser Tyr Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile 
            660                 665                 670         


Leu Ala Gly Ser Lys Lys Lys Ile Cys Thr Lys Lys Pro Arg Phe Met 
        675                 680                 685             


Ser Ala Cys Ala Gln Leu Val Ile Ala Phe Ile Leu Ile Cys Ile Gln 
    690                 695                 700                 


Leu Gly Ile Ile Val Ala Leu Phe Ile Met Glu Pro Pro Asp Ile Met 
705                 710                 715                 720 


His Asp Tyr Pro Ser Ile Arg Glu Val Tyr Leu Ile Cys Asn Thr Thr 
                725                 730                 735     


Asn Leu Gly Val Val Thr Pro Leu Gly Tyr Asn Gly Leu Leu Ile Leu 
            740                 745                 750         


Ser Cys Thr Phe Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe 
        755                 760                 765             


Asn Glu Ala Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile 
    770                 775                 780                 


Trp Leu Ala Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile 
785                 790                 795                 800 


Thr Met Cys Phe Ser Val Ser Leu Ser Ala Thr Val Ala Leu Gly Cys 
                805                 810                 815     


Met Phe Val Pro Lys Val Tyr Ile Ile Leu Ala Lys Pro Glu Arg Asn 
            820                 825                 830         


Val Arg Ser Ala Phe Thr Thr Ser Thr Val Val Arg Met His Val Gly 
        835                 840                 845             


Asp Gly Lys Ser Ser Ser Ala Ala Ser Arg Ser Ser Ser Leu Val Asn 
    850                 855                 860                 


Leu Trp Lys Arg Arg Gly Ser Ser Gly Glu Thr Leu Ser Ser Asn Gly 
865                 870                 875                 880 


Lys Ser Val Thr Trp Ala Gln Asn Glu Lys Ser Ser Arg Gly Gln His 
                885                 890                 895     


Leu Trp Gln Arg Leu Ser Ile His Ile Asn Lys Lys Glu Asn Pro Asn 
            900                 905                 910         


Gln Thr Ala Val Ile Lys Pro Phe Pro Lys Ser Thr Glu Ser Arg Gly 
        915                 920                 925             


Leu Gly Ala Gly Ala Gly Ala Gly Gly Ser Ala Gly Gly Val Gly Ala 
    930                 935                 940                 


Thr Gly Gly Ala Gly Cys Ala Gly Ala Gly Pro Gly Gly Pro Glu Ser 
945                 950                 955                 960 


Pro Asp Ala Gly Pro Lys Ala Leu Tyr Asp Val Ala Glu Ala Glu Glu 
                965                 970                 975     


His Phe Pro Ala Pro Ala Arg Pro Arg Ser Pro Ser Pro Ile Ser Thr 
            980                 985                 990         


Leu Ser His Arg Ala Gly Ser Ala  Ser Arg Thr Asp Asp  Asp Val Pro 
        995                 1000                 1005             


Ser Leu  His Ser Glu Pro Val  Ala Arg Ser Ser Ser  Ser Gln Gly 
    1010                 1015                 1020             


Ser Leu  Met Glu Gln Ile Ser  Ser Val Val Thr Arg  Phe Thr Ala 
    1025                 1030                 1035             


Asn Ile  Ser Glu Leu Asn Ser  Met Met Leu Ser Thr  Ala Ala Pro 
    1040                 1045                 1050             


Ser Pro  Gly Val Gly Ala Pro  Leu Cys Ser Ser Tyr  Leu Ile Pro 
    1055                 1060                 1065             


Lys Glu  Ile Gln Leu Pro Thr  Thr Met Thr Thr Phe  Ala Glu Ile 
    1070                 1075                 1080             


Gln Pro  Leu Pro Ala Ile Glu  Val Thr Gly Gly Ala  Gln Pro Ala 
    1085                 1090                 1095             


Ala Gly  Ala Gln Ala Ala Gly  Asp Ala Ala Arg Glu  Ser Pro Ala 
    1100                 1105                 1110             


Ala Gly  Pro Glu Ala Ala Ala  Ala Lys Pro Asp Leu  Glu Glu Leu 
    1115                 1120                 1125             


Val Ala  Leu Thr Pro Pro Ser  Pro Phe Arg Asp Ser  Val Asp Ser 
    1130                 1135                 1140             


Gly Ser  Thr Thr Pro Asn Ser  Pro Val Ser Glu Ser  Ala Leu Cys 
    1145                 1150                 1155             


Ile Pro  Ser Ser Pro Lys Tyr  Asp Thr Leu Ile Ile  Arg Asp Tyr 
    1160                 1165                 1170             


Thr Gln  Ser Ser Ser Ser Leu  
    1175                 1180 


<210>  3
<211>  1171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rat mGluR5

<400>  3

Met Val Leu Leu Leu Ile Leu Ser Val Leu Leu Leu Lys Glu Asp Val 
1               5                   10                  15      


Arg Gly Ser Ala Gln Ser Ser Glu Arg Arg Val Val Ala His Met Pro 
            20                  25                  30          


Gly Asp Ile Ile Ile Gly Ala Leu Phe Ser Val His His Gln Pro Thr 
        35                  40                  45              


Val Asp Lys Val His Glu Arg Lys Cys Gly Ala Val Arg Glu Gln Tyr 
    50                  55                  60                  


Gly Ile Gln Arg Val Glu Ala Met Leu His Thr Leu Glu Arg Ile Asn 
65                  70                  75                  80  


Ser Asp Pro Thr Leu Leu Pro Asn Ile Thr Leu Gly Cys Glu Ile Arg 
                85                  90                  95      


Asp Ser Cys Trp His Ser Ala Val Ala Leu Glu Gln Ser Ile Glu Phe 
            100                 105                 110         


Ile Arg Asp Ser Leu Ile Ser Ser Glu Glu Glu Glu Gly Leu Val Arg 
        115                 120                 125             


Cys Val Asp Gly Ser Ser Ser Phe Arg Ser Lys Lys Pro Ile Val Gly 
    130                 135                 140                 


Val Ile Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn Leu 
145                 150                 155                 160 


Leu Gln Leu Phe Asn Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser Met 
                165                 170                 175     


Asp Leu Ser Asp Lys Thr Leu Phe Lys Tyr Phe Met Arg Val Val Pro 
            180                 185                 190         


Ser Asp Ala Gln Gln Ala Arg Ala Met Val Asp Ile Val Lys Arg Tyr 
        195                 200                 205             


Asn Trp Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly Glu 
    210                 215                 220                 


Ser Gly Met Glu Ala Phe Lys Asp Met Ser Ala Lys Glu Gly Ile Cys 
225                 230                 235                 240 


Ile Ala His Ser Tyr Lys Ile Tyr Ser Asn Ala Gly Glu Gln Ser Phe 
                245                 250                 255     


Asp Lys Leu Leu Lys Lys Leu Arg Ser His Leu Pro Lys Ala Arg Val 
            260                 265                 270         


Val Ala Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Met Ala 
        275                 280                 285             


Met Arg Arg Leu Gly Leu Ala Gly Glu Phe Leu Leu Leu Gly Ser Asp 
    290                 295                 300                 


Gly Trp Ala Asp Arg Tyr Asp Val Thr Asp Gly Tyr Gln Arg Glu Ala 
305                 310                 315                 320 


Val Gly Gly Ile Thr Ile Lys Leu Gln Ser Pro Asp Val Lys Trp Phe 
                325                 330                 335     


Asp Asp Tyr Tyr Leu Lys Leu Arg Pro Glu Thr Asn Leu Arg Asn Pro 
            340                 345                 350         


Trp Phe Gln Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Glu Gly 
        355                 360                 365             


Phe Ala Gln Glu Asn Ser Lys Tyr Asn Lys Thr Cys Asn Ser Ser Leu 
    370                 375                 380                 


Thr Leu Arg Thr His His Val Gln Asp Ser Lys Met Gly Phe Val Ile 
385                 390                 395                 400 


Asn Ala Ile Tyr Ser Met Ala Tyr Gly Leu His Asn Met Gln Met Ser 
                405                 410                 415     


Leu Cys Pro Gly Tyr Ala Gly Leu Cys Asp Ala Met Lys Pro Ile Asp 
            420                 425                 430         


Gly Arg Lys Leu Leu Asp Ser Leu Met Lys Thr Asn Phe Thr Gly Val 
        435                 440                 445             


Ser Gly Asp Met Ile Leu Phe Asp Glu Asn Gly Asp Ser Pro Gly Arg 
    450                 455                 460                 


Tyr Glu Ile Met Asn Phe Lys Glu Met Gly Lys Asp Tyr Phe Asp Tyr 
465                 470                 475                 480 


Ile Asn Val Gly Ser Trp Asp Asn Gly Glu Leu Lys Met Asp Asp Asp 
                485                 490                 495     


Glu Val Trp Ser Lys Lys Asn Asn Ile Ile Arg Ser Val Cys Ser Glu 
            500                 505                 510         


Pro Cys Glu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val Ser 
        515                 520                 525             


Cys Cys Trp Thr Cys Thr Pro Cys Lys Glu Asn Glu Tyr Val Phe Asp 
    530                 535                 540                 


Glu Tyr Thr Cys Lys Ala Cys Gln Leu Gly Ser Trp Pro Thr Asp Asp 
545                 550                 555                 560 


Leu Thr Gly Cys Asp Leu Ile Pro Val Gln Tyr Leu Arg Trp Gly Asp 
                565                 570                 575     


Pro Glu Pro Ile Ala Ala Val Val Phe Ala Cys Leu Gly Leu Leu Ala 
            580                 585                 590         


Thr Leu Phe Val Thr Val Ile Phe Ile Ile Tyr Arg Asp Thr Pro Val 
        595                 600                 605             


Val Lys Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly Ile 
    610                 615                 620                 


Cys Leu Gly Tyr Leu Cys Thr Phe Cys Leu Ile Ala Lys Pro Lys Gln 
625                 630                 635                 640 


Ile Tyr Cys Tyr Leu Gln Arg Ile Gly Ile Gly Leu Ser Pro Ala Met 
                645                 650                 655     


Ser Tyr Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile Leu 
            660                 665                 670         


Ala Gly Ser Lys Lys Lys Ile Cys Thr Lys Lys Pro Arg Phe Met Ser 
        675                 680                 685             


Ala Cys Ala Gln Leu Val Ile Ala Phe Ile Leu Ile Cys Ile Gln Leu 
    690                 695                 700                 


Gly Ile Ile Val Ala Leu Phe Ile Met Glu Pro Pro Asp Ile Met His 
705                 710                 715                 720 


Asp Tyr Pro Ser Ile Arg Glu Val Tyr Leu Ile Cys Asn Thr Thr Asn 
                725                 730                 735     


Leu Gly Val Val Thr Pro Leu Gly Tyr Asn Gly Leu Leu Ile Leu Ser 
            740                 745                 750         


Cys Thr Phe Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe Asn 
        755                 760                 765             


Glu Ala Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp 
    770                 775                 780                 


Leu Ala Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile Thr 
785                 790                 795                 800 


Met Cys Phe Ser Val Ser Leu Ser Ala Thr Val Ala Leu Gly Cys Met 
                805                 810                 815     


Phe Val Pro Lys Val Tyr Ile Ile Leu Ala Lys Pro Glu Arg Asn Val 
            820                 825                 830         


Arg Ser Ala Phe Thr Thr Ser Thr Val Val Arg Met His Val Gly Asp 
        835                 840                 845             


Gly Lys Ser Ser Ser Ala Ala Ser Arg Ser Ser Ser Leu Val Asn Leu 
    850                 855                 860                 


Trp Lys Arg Arg Gly Ser Ser Gly Glu Thr Leu Ser Ser Asn Gly Lys 
865                 870                 875                 880 


Ser Val Thr Trp Ala Gln Asn Glu Lys Ser Thr Arg Gly Gln His Leu 
                885                 890                 895     


Trp Gln Arg Leu Ser Val His Ile Asn Lys Lys Glu Asn Pro Asn Gln 
            900                 905                 910         


Thr Ala Val Ile Lys Pro Phe Pro Lys Ser Thr Glu Asn Arg Gly Pro 
        915                 920                 925             


Gly Ala Ala Ala Gly Gly Gly Ser Gly Pro Gly Val Ala Gly Ala Gly 
    930                 935                 940                 


Asn Ala Gly Cys Thr Ala Thr Gly Gly Pro Glu Pro Pro Asp Ala Gly 
945                 950                 955                 960 


Pro Lys Ala Leu Tyr Asp Val Ala Glu Ala Glu Glu Ser Phe Pro Ala 
                965                 970                 975     


Ala Ala Arg Pro Arg Ser Pro Ser Pro Ile Ser Thr Leu Ser His Leu 
            980                 985                 990         


Ala Gly Ser Ala Gly Arg Thr Asp  Asp Asp Ala Pro Ser  Leu His Ser 
        995                 1000                 1005             


Glu Thr  Ala Ala Arg Ser Ser  Ser Ser Gln Gly Ser  Leu Met Glu 
    1010                 1015                 1020             


Gln Ile  Ser Ser Val Val Thr  Arg Phe Thr Ala Asn  Ile Ser Glu 
    1025                 1030                 1035             


Leu Asn  Ser Met Met Leu Ser  Thr Ala Ala Thr Pro  Gly Pro Pro 
    1040                 1045                 1050             


Gly Thr  Pro Ile Cys Ser Ser  Tyr Leu Ile Pro Lys  Glu Ile Gln 
    1055                 1060                 1065             


Leu Pro  Thr Thr Met Thr Thr  Phe Ala Glu Ile Gln  Pro Leu Pro 
    1070                 1075                 1080             


Ala Ile  Glu Val Thr Gly Gly  Ala Gln Gly Ala Thr  Gly Val Ser 
    1085                 1090                 1095             


Pro Ala  Gln Glu Thr Pro Thr  Gly Ala Glu Ser Ala  Pro Gly Lys 
    1100                 1105                 1110             


Pro Asp  Leu Glu Glu Leu Val  Ala Leu Thr Pro Pro  Ser Pro Phe 
    1115                 1120                 1125             


Arg Asp  Ser Val Asp Ser Gly  Ser Thr Thr Pro Asn  Ser Pro Val 
    1130                 1135                 1140             


Ser Glu  Ser Ala Leu Cys Ile  Pro Ser Ser Pro Lys  Tyr Asp Thr 
    1145                 1150                 1155             


Leu Ile  Ile Arg Asp Tyr Thr  Gln Ser Ser Ser Ser  Leu 
    1160                 1165                 1170     


<210>  4
<211>  1212
<212>  PRT
<213>  Cyno mGluR5

<400>  4

Met Val Leu Leu Leu Ile Leu Ser Val Leu Leu Leu Lys Glu Asp Val 
1               5                   10                  15      


Arg Gly Ser Ala Gln Ser Ser Glu Arg Arg Val Val Ala His Met Pro 
            20                  25                  30          


Gly Asp Ile Ile Ile Gly Ala Leu Phe Ser Val His His Gln Pro Thr 
        35                  40                  45              


Val Asp Lys Val His Glu Arg Lys Cys Gly Ala Val Arg Glu Gln Tyr 
    50                  55                  60                  


Gly Ile Gln Arg Val Glu Ala Met Leu His Thr Leu Glu Arg Ile Asn 
65                  70                  75                  80  


Ser Asp Pro Thr Leu Leu Pro Asn Ile Thr Leu Gly Cys Glu Ile Arg 
                85                  90                  95      


Asp Ser Cys Trp His Ser Ala Val Ala Leu Glu Gln Ser Ile Glu Phe 
            100                 105                 110         


Ile Arg Asp Ser Leu Ile Ser Ser Glu Glu Glu Glu Gly Leu Val Arg 
        115                 120                 125             


Cys Val Asp Gly Ser Ser Ser Ser Phe Arg Ser Lys Lys Pro Ile Val 
    130                 135                 140                 


Gly Val Ile Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn 
145                 150                 155                 160 


Leu Leu Gln Leu Phe Asn Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser 
                165                 170                 175     


Met Asp Leu Ser Asp Lys Thr Leu Phe Lys Tyr Phe Met Arg Val Val 
            180                 185                 190         


Pro Ser Asp Ala Gln Gln Ala Arg Ala Met Val Asp Ile Val Lys Arg 
        195                 200                 205             


Tyr Asn Trp Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly 
    210                 215                 220                 


Glu Ser Gly Met Glu Ala Phe Lys Asp Met Ser Ala Lys Glu Gly Ile 
225                 230                 235                 240 


Cys Ile Ala His Ser Tyr Lys Ile Tyr Ser Asn Ala Gly Glu Gln Ser 
                245                 250                 255     


Phe Asp Lys Leu Leu Lys Lys Leu Thr Ser His Leu Pro Lys Ala Arg 
            260                 265                 270         


Val Val Ala Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Met 
        275                 280                 285             


Ala Met Arg Arg Leu Gly Leu Ala Gly Glu Phe Leu Leu Leu Gly Ser 
    290                 295                 300                 


Asp Gly Trp Ala Asp Arg Tyr Asp Val Thr Asp Gly Tyr Gln Arg Glu 
305                 310                 315                 320 


Ala Val Gly Gly Ile Thr Ile Lys Leu Gln Ser Pro Asp Val Lys Trp 
                325                 330                 335     


Phe Asp Asp Tyr Tyr Leu Lys Leu Arg Pro Glu Thr Asn His Arg Asn 
            340                 345                 350         


Pro Trp Phe Gln Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Glu 
        355                 360                 365             


Gly Phe Pro Gln Glu Asn Ser Lys Tyr Asn Lys Thr Cys Asp Ser Ser 
    370                 375                 380                 


Leu Thr Leu Lys Thr His His Val Gln Asp Ser Lys Met Gly Phe Val 
385                 390                 395                 400 


Ile Asn Ala Ile Tyr Ser Met Ala Tyr Gly Leu His Asn Met Gln Met 
                405                 410                 415     


Ser Leu Cys Pro Gly Tyr Ala Gly Leu Cys Asp Ala Met Lys Pro Ile 
            420                 425                 430         


Asp Gly Arg Lys Leu Leu Glu Ser Leu Met Lys Thr Asn Phe Thr Gly 
        435                 440                 445             


Val Ser Gly Asp Met Ile Leu Phe Asp Glu Asn Gly Asp Ser Pro Gly 
    450                 455                 460                 


Arg Tyr Glu Ile Met Asn Phe Lys Glu Met Gly Lys Asp Tyr Phe Asp 
465                 470                 475                 480 


Tyr Ile Asn Val Gly Ser Trp Asp Asn Gly Glu Leu Lys Met Asp Asp 
                485                 490                 495     


Asp Glu Val Trp Ser Lys Lys Ser Asn Ile Ile Arg Ser Val Cys Ser 
            500                 505                 510         


Glu Pro Cys Glu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val 
        515                 520                 525             


Ser Cys Cys Trp Thr Cys Thr Pro Cys Lys Glu Asn Glu Tyr Val Phe 
    530                 535                 540                 


Asp Glu Tyr Thr Cys Lys Ala Cys Gln Leu Gly Ser Trp Pro Thr Asp 
545                 550                 555                 560 


Asp Leu Thr Gly Cys Asp Leu Ile Pro Val Gln Tyr Leu Arg Trp Gly 
                565                 570                 575     


Asp Pro Glu Pro Ile Ala Ala Val Val Phe Ala Cys Leu Gly Leu Leu 
            580                 585                 590         


Ala Thr Leu Phe Val Thr Val Val Phe Ile Ile Tyr Arg Asp Thr Pro 
        595                 600                 605             


Val Val Lys Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly 
    610                 615                 620                 


Ile Cys Leu Gly Tyr Leu Cys Thr Phe Cys Leu Ile Ala Lys Pro Lys 
625                 630                 635                 640 


Gln Ile Tyr Cys Tyr Leu Gln Arg Ile Gly Ile Gly Leu Ser Pro Ala 
                645                 650                 655     


Met Ser Tyr Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile 
            660                 665                 670         


Leu Ala Gly Ser Lys Lys Lys Ile Cys Thr Lys Lys Pro Arg Phe Met 
        675                 680                 685             


Ser Ala Cys Ala Gln Leu Val Ile Ala Phe Ile Leu Ile Cys Ile Gln 
    690                 695                 700                 


Leu Gly Ile Ile Val Ala Leu Phe Ile Met Glu Pro Pro Asp Ile Met 
705                 710                 715                 720 


His Asp Tyr Pro Ser Ile Arg Glu Val Tyr Leu Ile Cys Asn Thr Thr 
                725                 730                 735     


Asn Leu Gly Val Val Thr Pro Leu Gly Tyr Asn Gly Leu Leu Ile Leu 
            740                 745                 750         


Ser Cys Thr Phe Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe 
        755                 760                 765             


Asn Glu Ala Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile 
    770                 775                 780                 


Trp Leu Ala Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile 
785                 790                 795                 800 


Thr Met Cys Phe Ser Val Ser Leu Ser Ala Thr Val Ala Leu Gly Cys 
                805                 810                 815     


Met Phe Val Pro Lys Val Tyr Ile Ile Leu Ala Lys Pro Glu Arg Asn 
            820                 825                 830         


Val Arg Ser Ala Phe Thr Thr Ser Thr Val Val Arg Met His Val Gly 
        835                 840                 845             


Asp Gly Lys Ser Ser Ser Ala Ala Ser Arg Ser Ser Ser Leu Val Asn 
    850                 855                 860                 


Leu Trp Lys Arg Arg Gly Ser Ser Gly Glu Thr Leu Arg Tyr Lys Asp 
865                 870                 875                 880 


Arg Arg Leu Ala Gln His Lys Ser Glu Ile Glu Cys Phe Thr Pro Lys 
                885                 890                 895     


Gly Ser Met Gly Asn Gly Gly Arg Ala Thr Met Ser Ser Ser Asn Gly 
            900                 905                 910         


Lys Ser Val Thr Trp Ala Gln Asn Glu Lys Ser Ser Arg Gly Gln His 
        915                 920                 925             


Leu Trp Gln Arg Leu Ser Ile His Ile Asn Lys Lys Glu Asn Pro Asn 
    930                 935                 940                 


Gln Thr Ala Val Ile Lys Pro Phe Pro Lys Ser Thr Glu Ser Arg Gly 
945                 950                 955                 960 


Leu Gly Ala Gly Ala Gly Ala Gly Gly Ser Ala Gly Gly Met Gly Ala 
                965                 970                 975     


Thr Gly Gly Ala Gly Cys Ala Gly Ala Gly Pro Gly Gly Pro Glu Pro 
            980                 985                 990         


Pro Asp Ala Ser Pro Lys Gly Leu  Tyr Asp Val Ala Glu  Thr Glu Glu 
        995                 1000                 1005             


His Phe  Pro Ala Pro Thr Arg  Pro Arg Ser Pro Ser  Pro Ile Ser 
    1010                 1015                 1020             


Thr Leu  Ser His Arg Ala Gly  Ser Ala Ser Arg Thr  Asp Asp Asp 
    1025                 1030                 1035             


Val Pro  Ser Leu His Ser Glu  Pro Ala Ala Arg Ser  Ser Ser Ser 
    1040                 1045                 1050             


Gln Gly  Ser Leu Met Glu Gln  Ile Ser Ser Val Val  Thr Arg Phe 
    1055                 1060                 1065             


Thr Ala  Asn Ile Ser Glu Leu  Asn Ser Met Met Leu  Ser Thr Ala 
    1070                 1075                 1080             


Ala Pro  Ser Pro Gly Val Gly  Ala Pro Leu Cys Ser  Ser Tyr Leu 
    1085                 1090                 1095             


Ile Pro  Lys Glu Ile Gln Leu  Pro Thr Thr Met Thr  Thr Phe Ala 
    1100                 1105                 1110             


Glu Ile  Gln Pro Leu Pro Ala  Ile Glu Val Thr Gly  Gly Ala Gln 
    1115                 1120                 1125             


Pro Ala  Ala Gly Ala Gln Ala  Ala Gly Asp Ala Ala  Arg Glu Ser 
    1130                 1135                 1140             


Pro Ala  Ala Gly Pro Lys Ala  Ala Ala Ala Lys Pro  Asp Leu Glu 
    1145                 1150                 1155             


Glu Leu  Val Ala Leu Thr Pro  Pro Ser Pro Phe Arg  Asp Ser Val 
    1160                 1165                 1170             


Asp Ser  Gly Ser Thr Thr Pro  Asn Ser Pro Val Ser  Glu Ser Ala 
    1175                 1180                 1185             


Leu Cys  Ile Pro Ser Ser Pro  Lys Tyr Asp Thr Leu  Ile Ile Arg 
    1190                 1195                 1200             


Asp Tyr  Thr Gln Ser Ser Ser  Ser Leu 
    1205                 1210         


<210>  5
<211>  1194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human mGluR1

<400>  5

Met Val Gly Leu Leu Leu Phe Phe Phe Pro Ala Ile Phe Leu Glu Val 
1               5                   10                  15      


Ser Leu Leu Pro Arg Ser Pro Gly Arg Lys Val Leu Leu Ala Gly Ala 
            20                  25                  30          


Ser Ser Gln Arg Ser Val Ala Arg Met Asp Gly Asp Val Ile Ile Gly 
        35                  40                  45              


Ala Leu Phe Ser Val His His Gln Pro Pro Ala Glu Lys Val Pro Glu 
    50                  55                  60                  


Arg Lys Cys Gly Glu Ile Arg Glu Gln Tyr Gly Ile Gln Arg Val Glu 
65                  70                  75                  80  


Ala Met Phe His Thr Leu Asp Lys Ile Asn Ala Asp Pro Val Leu Leu 
                85                  90                  95      


Pro Asn Ile Thr Leu Gly Ser Glu Ile Arg Asp Ser Cys Trp His Ser 
            100                 105                 110         


Ser Val Ala Leu Glu Gln Ser Ile Glu Phe Ile Arg Asp Ser Leu Ile 
        115                 120                 125             


Ser Ile Arg Asp Glu Lys Asp Gly Ile Asn Arg Cys Leu Pro Asp Gly 
    130                 135                 140                 


Gln Ser Leu Pro Pro Gly Arg Thr Lys Lys Pro Ile Ala Gly Val Ile 
145                 150                 155                 160 


Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn Leu Leu Gln 
                165                 170                 175     


Leu Phe Asp Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser Ile Asp Leu 
            180                 185                 190         


Ser Asp Lys Thr Leu Tyr Lys Tyr Phe Leu Arg Val Val Pro Ser Asp 
        195                 200                 205             


Thr Leu Gln Ala Arg Ala Met Leu Asp Ile Val Lys Arg Tyr Asn Trp 
    210                 215                 220                 


Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly Glu Ser Gly 
225                 230                 235                 240 


Met Asp Ala Phe Lys Glu Leu Ala Ala Gln Glu Gly Leu Cys Ile Ala 
                245                 250                 255     


His Ser Asp Lys Ile Tyr Ser Asn Ala Gly Glu Lys Ser Phe Asp Arg 
            260                 265                 270         


Leu Leu Arg Lys Leu Arg Glu Arg Leu Pro Lys Ala Arg Val Val Val 
        275                 280                 285             


Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Ser Ala Met Arg 
    290                 295                 300                 


Arg Leu Gly Val Val Gly Glu Phe Ser Leu Ile Gly Ser Asp Gly Trp 
305                 310                 315                 320 


Ala Asp Arg Asp Glu Val Ile Glu Gly Tyr Glu Val Glu Ala Asn Gly 
                325                 330                 335     


Gly Ile Thr Ile Lys Leu Gln Ser Pro Glu Val Arg Ser Phe Asp Asp 
            340                 345                 350         


Tyr Phe Leu Lys Leu Arg Leu Asp Thr Asn Thr Arg Asn Pro Trp Phe 
        355                 360                 365             


Pro Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Pro Gly His Leu 
    370                 375                 380                 


Leu Glu Asn Pro Asn Phe Lys Arg Ile Cys Thr Gly Asn Glu Ser Leu 
385                 390                 395                 400 


Glu Glu Asn Tyr Val Gln Asp Ser Lys Met Gly Phe Val Ile Asn Ala 
                405                 410                 415     


Ile Tyr Ala Met Ala His Gly Leu Gln Asn Met His His Ala Leu Cys 
            420                 425                 430         


Pro Gly His Val Gly Leu Cys Asp Ala Met Lys Pro Ile Asp Gly Ser 
        435                 440                 445             


Lys Leu Leu Asp Phe Leu Ile Lys Ser Ser Phe Ile Gly Val Ser Gly 
    450                 455                 460                 


Glu Glu Val Trp Phe Asp Glu Lys Gly Asp Ala Pro Gly Arg Tyr Asp 
465                 470                 475                 480 


Ile Met Asn Leu Gln Tyr Thr Glu Ala Asn Arg Tyr Asp Tyr Val His 
                485                 490                 495     


Val Gly Thr Trp His Glu Gly Val Leu Asn Ile Asp Asp Tyr Lys Ile 
            500                 505                 510         


Gln Met Asn Lys Ser Gly Val Val Arg Ser Val Cys Ser Glu Pro Cys 
        515                 520                 525             


Leu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val Ser Cys Cys 
    530                 535                 540                 


Trp Ile Cys Thr Ala Cys Lys Glu Asn Glu Tyr Val Gln Asp Glu Phe 
545                 550                 555                 560 


Thr Cys Lys Ala Cys Asp Leu Gly Trp Trp Pro Asn Ala Asp Leu Thr 
                565                 570                 575     


Gly Cys Glu Pro Ile Pro Val Arg Tyr Leu Glu Trp Ser Asn Ile Glu 
            580                 585                 590         


Ser Ile Ile Ala Ile Ala Phe Ser Cys Leu Gly Ile Leu Val Thr Leu 
        595                 600                 605             


Phe Val Thr Leu Ile Phe Val Leu Tyr Arg Asp Thr Pro Val Val Lys 
    610                 615                 620                 


Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly Ile Phe Leu 
625                 630                 635                 640 


Gly Tyr Val Cys Pro Phe Thr Leu Ile Ala Lys Pro Thr Thr Thr Ser 
                645                 650                 655     


Cys Tyr Leu Gln Arg Leu Leu Val Gly Leu Ser Ser Ala Met Cys Tyr 
            660                 665                 670         


Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile Leu Ala Gly 
        675                 680                 685             


Ser Lys Lys Lys Ile Cys Thr Arg Lys Pro Arg Phe Met Ser Ala Trp 
    690                 695                 700                 


Ala Gln Val Ile Ile Ala Ser Ile Leu Ile Ser Val Gln Leu Thr Leu 
705                 710                 715                 720 


Val Val Thr Leu Ile Ile Met Glu Pro Pro Met Pro Ile Leu Ser Tyr 
                725                 730                 735     


Pro Ser Ile Lys Glu Val Tyr Leu Ile Cys Asn Thr Ser Asn Leu Gly 
            740                 745                 750         


Val Val Ala Pro Leu Gly Tyr Asn Gly Leu Leu Ile Met Ser Cys Thr 
        755                 760                 765             


Tyr Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe Asn Glu Ala 
    770                 775                 780                 


Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala 
785                 790                 795                 800 


Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile Thr Thr Cys 
                805                 810                 815     


Phe Ala Val Ser Leu Ser Val Thr Val Ala Leu Gly Cys Met Phe Thr 
            820                 825                 830         


Pro Lys Met Tyr Ile Ile Ile Ala Lys Pro Glu Arg Asn Val Arg Ser 
        835                 840                 845             


Ala Phe Thr Thr Ser Asp Val Val Arg Met His Val Gly Asp Gly Lys 
    850                 855                 860                 


Leu Pro Cys Arg Ser Asn Thr Phe Leu Asn Ile Phe Arg Arg Lys Lys 
865                 870                 875                 880 


Ala Gly Ala Gly Asn Ala Asn Ser Asn Gly Lys Ser Val Ser Trp Ser 
                885                 890                 895     


Glu Pro Gly Gly Gly Gln Val Pro Lys Gly Gln His Met Trp His Arg 
            900                 905                 910         


Leu Ser Val His Val Lys Thr Asn Glu Thr Ala Cys Asn Gln Thr Ala 
        915                 920                 925             


Val Ile Lys Pro Leu Thr Lys Ser Tyr Gln Gly Ser Gly Lys Ser Leu 
    930                 935                 940                 


Thr Phe Ser Asp Thr Ser Thr Lys Thr Leu Tyr Asn Val Glu Glu Glu 
945                 950                 955                 960 


Glu Asp Ala Gln Pro Ile Arg Phe Ser Pro Pro Gly Ser Pro Ser Met 
                965                 970                 975     


Val Val His Arg Arg Val Pro Ser Ala Ala Thr Thr Pro Pro Leu Pro 
            980                 985                 990         


Ser His Leu Thr Ala Glu Glu Thr  Pro Leu Phe Leu Ala  Glu Pro Ala 
        995                 1000                 1005             


Leu Pro  Lys Gly Leu Pro Pro  Pro Leu Gln Gln Gln  Gln Gln Pro 
    1010                 1015                 1020             


Pro Pro  Gln Gln Lys Ser Leu  Met Asp Gln Leu Gln  Gly Val Val 
    1025                 1030                 1035             


Ser Asn  Phe Ser Thr Ala Ile  Pro Asp Phe His Ala  Val Leu Ala 
    1040                 1045                 1050             


Gly Pro  Gly Gly Pro Gly Asn  Gly Leu Arg Ser Leu  Tyr Pro Pro 
    1055                 1060                 1065             


Pro Pro  Pro Pro Gln His Leu  Gln Met Leu Pro Leu  Gln Leu Ser 
    1070                 1075                 1080             


Thr Phe  Gly Glu Glu Leu Val  Ser Pro Pro Ala Asp  Asp Asp Asp 
    1085                 1090                 1095             


Asp Ser  Glu Arg Phe Lys Leu  Leu Gln Glu Tyr Val  Tyr Glu His 
    1100                 1105                 1110             


Glu Arg  Glu Gly Asn Thr Glu  Glu Asp Glu Leu Glu  Glu Glu Glu 
    1115                 1120                 1125             


Glu Asp  Leu Gln Ala Ala Ser  Lys Leu Thr Pro Asp  Asp Ser Pro 
    1130                 1135                 1140             


Ala Leu  Thr Pro Pro Ser Pro  Phe Arg Asp Ser Val  Ala Ser Gly 
    1145                 1150                 1155             


Ser Ser  Val Pro Ser Ser Pro  Val Ser Glu Ser Val  Leu Cys Thr 
    1160                 1165                 1170             


Pro Pro  Asn Val Ser Tyr Ala  Ser Val Ile Leu Arg  Asp Tyr Lys 
    1175                 1180                 1185             


Gln Ser  Ser Ser Thr Leu 
    1190                 


<210>  6
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab1_VH VH

<400>  6
cagcagcagc tggaggagtc cgggggaggc ctggtcaagc ctggaggaac cctgacactc       60

acctgcaaag tctctgggat cgacttcagt agctactact acatgtgctg ggtccgccag      120

gctccaggga aggggctgga gtggatcgca tgcatttatg ctggtgatgg tggcacttac      180

tacgcgagct gggcgaaagg ccgattcacc agctccaaaa cctcgtcgac cacggtgact      240

ctgcaaatga ccagtctgac agccgcggac acggccacct atttctgtgc gaggggtagt      300

ggtgttggta gttatggtta cagcttgtgg ggcccaggca ccctcgtcac cgtctcgagc      360


<210>  7
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab1_VH VH

<400>  7

Gln Gln Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Lys Val Ser Gly Ile Asp Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Tyr Ala Gly Asp Gly Gly Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ser Ser Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Val Gly Ser Tyr Gly Tyr Ser Leu Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  8
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab1_VH CDRH1

<400>  8
agctactact acatgtgc                                                     18


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab1_VH CDRH1

<400>  9

Ser Tyr Tyr Tyr Met Cys 
1               5       


<210>  10
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab1_VH CDRH2

<400>  10
tgcatttatg ctggtgatgg tggcacttac tacgcgagct gggcgaaagg c                51


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab1_VH CDRH2

<400>  11

Cys Ile Tyr Ala Gly Asp Gly Gly Thr Tyr Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab1_VH CDRH3

<400>  12
ggtagtggtg ttggtagtta tggttacagc ttg                                    33


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab1_VH CDRH3

<400>  13

Gly Ser Gly Val Gly Ser Tyr Gly Tyr Ser Leu 
1               5                   10      


<210>  14
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab1_VL VL

<400>  14
gctgacattg tgatgaccca gactccagcc tccgtggagg cagctgtggg aggcacagtc       60

accatcaagt gccaggccag tgagagcatt tatagcaatt tagcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctaatctac agggcatcca atctggaatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca gaatttactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa ggctattatg ccagtactac tactaatgct      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  15
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab1_VL VL

<400>  15

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Tyr Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Ala Ser Thr 
                85                  90                  95      


Thr Thr Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  16
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab1_VL CDRL1

<400>  16
caggccagtg agagcattta tagcaattta gcc                                    33


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab1_VL CDRL1

<400>  17

Gln Ala Ser Glu Ser Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab1_VL CDRL2

<400>  18
agggcatcca atctggaatc t                                                 21


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab1_VL CDRL2

<400>  19

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  20
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab1_VL CDRL3

<400>  20
caaggctatt atgccagtac tactactaat gct                                    33


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab1_VL CDRL3

<400>  21

Gln Gly Tyr Tyr Ala Ser Thr Thr Thr Asn Ala 
1               5                   10      


<210>  22
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab2_VH VH

<400>  22
cagcagcagc tggaggagtc cgggggaggc ctggtcaagc ctggaggaac cctgacactc       60

acctgcaaag cctctggaat cgacttcagt ggctactact acatgtgctg ggtccgccag      120

gctccaggga aggggctgga gtggatcgca tgcgtttata ctggtgatgg tggcacttac      180

tacgcgagct gggcgaaagg ccgattcacc atctccaaaa cctcgtcgac cacggtgact      240

ctgcaaatga ccagtctgac agccgcggac acggccacct atttctgtgc gaggggtagt      300

ggtgttggta gttatggtta caacttgtgg ggccaaggga ccctcgtcac cgtctcgagc      360


<210>  23
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab2_VH VH

<400>  23

Gln Gln Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Lys Ala Ser Gly Ile Asp Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Val Tyr Thr Gly Asp Gly Gly Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Val Gly Ser Tyr Gly Tyr Asn Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  24
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab2_VH CDRH1

<400>  24
ggctactact acatgtgc                                                     18


<210>  25
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab2_VH CDRH1

<400>  25

Gly Tyr Tyr Tyr Met Cys 
1               5       


<210>  26
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab2_VH CDRH2

<400>  26
tgcgtttata ctggtgatgg tggcacttac tacgcgagct gggcgaaagg c                51


<210>  27
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab2_VH CDRH2

<400>  27

Cys Val Tyr Thr Gly Asp Gly Gly Thr Tyr Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  28
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab2_VH CDRH3

<400>  28
ggtagtggtg ttggtagtta tggttacaac ttg                                    33


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab2_VH CDRH3

<400>  29

Gly Ser Gly Val Gly Ser Tyr Gly Tyr Asn Leu 
1               5                   10      


<210>  30
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab2_VL VL

<400>  30
gctgacattg tgatgaccca gactccagcc tccgtggagg cagctgtggg aggcacagtc       60

accatcaagt gccaggccag tgagagcatt tatagcaatt tagcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctaatctac agggcatcca atctggaatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca gagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa ggctattatg ccattactac tactaatgct      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  31
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab2_VL VL

<400>  31

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Tyr Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Ala Ile Thr 
                85                  90                  95      


Thr Thr Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  32
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab2_VL CDRL1

<400>  32
caggccagtg agagcattta tagcaattta gcc                                    33


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab2_VL CDRL1

<400>  33

Gln Ala Ser Glu Ser Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab2_VL CDRL2

<400>  34
agggcatcca atctggaatc t                                                 21


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab2_VL CDRL2

<400>  35

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  36
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab2_VL CDRL3

<400>  36
caaggctatt atgccattac tactactaat gct                                    33


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab2_VL CDRL3

<400>  37

Gln Gly Tyr Tyr Ala Ile Thr Thr Thr Asn Ala 
1               5                   10      


<210>  38
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab3_VH VH

<400>  38
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcga cctcagtagc tatgcagtgg gctgggtccg ccaggctcca      120

gggaaggggc tggaatacat cggaatcatt tatgctagtg gtaacacatg gtacgcgagc      180

tgggtgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaagttggcc      240

agtctgacaa ccgaggacac ggccacctat ttctgtgcca gaggtcatgg tgctacttat      300

gactacttta atttgtgggg cccgggcacc ctcgtcaccg tctcgagc                   348


<210>  39
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab3_VH VH

<400>  39

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr Ala 
            20                  25                  30          


Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Ile Ile Tyr Ala Ser Gly Asn Thr Trp Tyr Ala Ser Trp Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Leu Ala 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly His 
                85                  90                  95      


Gly Ala Thr Tyr Asp Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  40
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab3_VH CDRH1

<400>  40
agctatgcag tgggc                                                        15


<210>  41
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab3_VH CDRH1

<400>  41

Ser Tyr Ala Val Gly 
1               5   


<210>  42
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab3_VH CDRH2

<400>  42
atcatttatg ctagtggtaa cacatggtac gcgagctggg tgaaaggc                    48


<210>  43
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab3_VH CDRH2

<400>  43

Ile Ile Tyr Ala Ser Gly Asn Thr Trp Tyr Ala Ser Trp Val Lys Gly 
1               5                   10                  15      


<210>  44
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab3_VH CDRH3

<400>  44
ggtcatggtg ctacttatga ctactttaat ttg                                    33


<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab3_VH CDRH3

<400>  45

Gly His Gly Ala Thr Tyr Asp Tyr Phe Asn Leu 
1               5                   10      


<210>  46
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab3_VL VL

<400>  46
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gagcattagt agctacttag cctggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctatgat gcatccgatc tggcatctgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggacagag tacactctca ccatcagcgg cgtgcagtgt      240

gacgatgctg ccacttacta ctgtcaacag ggtcttgcta ctgctaatgt tgataatgtt      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  47
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab3_VL VL

<400>  47

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Leu Ala Thr Ala Asn 
                85                  90                  95      


Val Asp Asn Val Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  48
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab3_VL CDRL1

<400>  48
caggccagtc agagcattag tagctactta gcc                                    33


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab3_VL CDRL1

<400>  49

Gln Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  50
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab3_VL CDRL2

<400>  50
gatgcatccg atctggcatc t                                                 21


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab3_VL CDRL2

<400>  51

Asp Ala Ser Asp Leu Ala Ser 
1               5           


<210>  52
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab3_VL CDRL3

<400>  52
caacagggtc ttgctactgc taatgttgat aatgtt                                 36


<210>  53
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab3_VL CDRL3

<400>  53

Gln Gln Gly Leu Ala Thr Ala Asn Val Asp Asn Val 
1               5                   10          


<210>  54
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab4_VH VH

<400>  54
cagcagcagc tggaggagtc cgggggaggc ctggtcaagc ctggaggaac cctgacactc       60

acctgcaaag gctctggaat cgacttcaat gactaccagt acatgtgctg ggtccgccag      120

gctccaggga aggggctgga gtggatcgcg tgcatttata atggggatgg tgagacttac      180

tacgcgcact gggcgaaagg ccgattcacc atctccaaaa cctcgtcgac cacggtgact      240

ctgcagatga ccagtctgac agccgcggac acggccacct atttctgtgc gaggggtagt      300

ggtgttggga gttatggtta caacttttgg ggcccgggca ccctcgtcac cgtctcgagc      360


<210>  55
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab4_VH VH

<400>  55

Gln Gln Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Lys Gly Ser Gly Ile Asp Phe Asn Asp Tyr 
            20                  25                  30          


Gln Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Tyr Asn Gly Asp Gly Glu Thr Tyr Tyr Ala His Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Val Gly Ser Tyr Gly Tyr Asn Phe Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  56
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab4_VH CDRH1

<400>  56
gactaccagt acatgtgc                                                     18


<210>  57
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab4_VH CDRH1

<400>  57

Asp Tyr Gln Tyr Met Cys 
1               5       


<210>  58
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab4_VH CDRH2

<400>  58
tgcatttata atggggatgg tgagacttac tacgcgcact gggcgaaagg c                51


<210>  59
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab4_VH CDRH2

<400>  59

Cys Ile Tyr Asn Gly Asp Gly Glu Thr Tyr Tyr Ala His Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  60
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab4_VH CDRH3

<400>  60
ggtagtggtg ttgggagtta tggttacaac ttt                                    33


<210>  61
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab4_VH CDRH3

<400>  61

Gly Ser Gly Val Gly Ser Tyr Gly Tyr Asn Phe 
1               5                   10      


<210>  62
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab4_VL VL

<400>  62
gctgacattg tgatgaccca gactccagcc tccgtggagg cagctgtggg aggcacagtc       60

accatcaagt gccaggccag tgagagcatt tacagcaatt tagcctggta tcagcagaaa      120

gcagggcagc ctcccaagct cctaatctac agggcatcca atctggcatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca gagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa ggctattatg ccagtactgt tactaatggt      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  63
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab4_VL VL

<400>  63

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Tyr Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Ala Ser Thr 
                85                  90                  95      


Val Thr Asn Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  64
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab4_VL CDRL1

<400>  64
caggccagtg agagcattta cagcaattta gcc                                    33


<210>  65
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab4_VL CDRL1

<400>  65

Gln Ala Ser Glu Ser Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  66
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab4_VL CDRL2

<400>  66
agggcatcca atctggcatc t                                                 21


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab4_VL CDRL2

<400>  67

Arg Ala Ser Asn Leu Ala Ser 
1               5           


<210>  68
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab4_VL CDRL3

<400>  68
caaggctatt atgccagtac tgttactaat ggt                                    33


<210>  69
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab4_VL CDRL3

<400>  69

Gln Gly Tyr Tyr Ala Ser Thr Val Thr Asn Gly 
1               5                   10      


<210>  70
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab5_VH VH

<400>  70
caggagcagc tggtggagtc cgggggaggc ctggtccagc ctgagggatc cctgacactc       60

acctgcacag cctctggaat cgacttcagt agcggctatt tcatgtgctg ggtccgccag      120

gctccaggga aggggctgga gtggatcgca tgcatttcgc cttatagtga taatacatgg      180

tacgcgaact gggcgaaagg ccgattcacc atctccaaaa cctcgtcgac cacggtgact      240

ctgcaaatga ccagtctgac agccgcggac acggccgcct atcgctgtgc gagaactatg      300

gctattggcg cttataaccc ctttaagttg tggggccagg gcaccctggt caccgtctcg      360

agc                                                                    363


<210>  71
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab5_VH VH

<400>  71

Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Ile Asp Phe Ser Ser Gly 
            20                  25                  30          


Tyr Phe Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Ser Pro Tyr Ser Asp Asn Thr Trp Tyr Ala Asn Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Ala Tyr Arg Cys 
                85                  90                  95      


Ala Arg Thr Met Ala Ile Gly Ala Tyr Asn Pro Phe Lys Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  72
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab5_VH CDRH1

<400>  72
agcggctatt tcatgtgc                                                     18


<210>  73
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab5_VH CDRH1

<400>  73

Ser Gly Tyr Phe Met Cys 
1               5       


<210>  74
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab5_VH CDRH2

<400>  74
tgcatttcgc cttatagtga taatacatgg tacgcgaact gggcgaaagg c                51


<210>  75
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab5_VH CDRH2

<400>  75

Cys Ile Ser Pro Tyr Ser Asp Asn Thr Trp Tyr Ala Asn Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  76
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab5_VH CDRH3

<400>  76
actatggcta ttggcgctta taaccccttt aagttg                                 36


<210>  77
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab5_VH CDRH3

<400>  77

Thr Met Ala Ile Gly Ala Tyr Asn Pro Phe Lys Leu 
1               5                   10          


<210>  78
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab5_VL VL

<400>  78
gcccttgtga tgacccagac tccatcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaattgcc aggccagtca gaacatttac agcaatttag cctggtatca gcagaaacca      120

gggcagcgtc ccaagctcct gatctatgat gcatccgatc tggcatctgg ggtctcatcg      180

cgggtcaaag gcagtggatc tgggacagag ttcactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaaggc tattattctg gtaatgcttt cggcggaggg      300

accgaggtgg tggtcaaacg t                                                321


<210>  79
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab5_VL VL

<400>  79

Ala Leu Val Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Ser Ser Arg Val Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Ser Gly Asn Ala 
                85                  90                  95      


Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105         


<210>  80
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab5_VL CDRL1

<400>  80
caggccagtc agaacattta cagcaattta gcc                                    33


<210>  81
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab5_VL CDRL1

<400>  81

Gln Ala Ser Gln Asn Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  82
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab5_VL CDRL2

<400>  82
gatgcatccg atctggcatc t                                                 21


<210>  83
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab5_VL CDRL2

<400>  83

Asp Ala Ser Asp Leu Ala Ser 
1               5           


<210>  84
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab5_VL CDRL3

<400>  84
caaggctatt attctggtaa tgct                                              24


<210>  85
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab5_VL CDRL3

<400>  85

Gln Gly Tyr Tyr Ser Gly Asn Ala 
1               5               


<210>  86
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab6_VH VH

<400>  86
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg gaggaaccct aacactcacc       60

tgcacagtct ctggaatcga cctcagtagc tatgcaatga gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggaatcatt tatgctagtg gtaacacatg gtacgcgaac      180

tgggtgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatgacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gagatagtag tgctactttt      300

aattatctag acttgtgggg ccaaggcacc ctcgtcaccg tctcgagc                   348


<210>  87
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab6_VH VH

<400>  87

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Tyr Ala Ser Gly Asn Thr Trp Tyr Ala Asn Trp Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Ser 
                85                  90                  95      


Ser Ala Thr Phe Asn Tyr Leu Asp Leu Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  88
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab6_VH CDRH1

<400>  88
agctatgcaa tgagc                                                        15


<210>  89
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab6_VH CDRH1

<400>  89

Ser Tyr Ala Met Ser 
1               5   


<210>  90
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab6_VH CDRH2

<400>  90
atcatttatg ctagtggtaa cacatggtac gcgaactggg tgaaaggc                    48


<210>  91
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab6_VH CDRH2

<400>  91

Ile Ile Tyr Ala Ser Gly Asn Thr Trp Tyr Ala Asn Trp Val Lys Gly 
1               5                   10                  15      


<210>  92
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab6_VH CDRH3

<400>  92
gatagtagtg ctacttttaa ttatctagac ttg                                    33


<210>  93
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab6_VH CDRH3

<400>  93

Asp Ser Ser Ala Thr Phe Asn Tyr Leu Asp Leu 
1               5                   10      


<210>  94
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab6_VL VL

<400>  94
gcctttcata tgacccagac tccagcctct atggaggtag ctgtgggagg cacagtcacc       60

atgaagtgcc aggccagtga gagcattgat acctacttaa actggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctaccag gcatccaaac tggcatctgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcagcgg cgtggagtgt      240

gccgatgctg ccacttacta ctgtcaacag ggttggagta ctaatgatgt tgataatgtt      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  95
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab6_VL VL

<400>  95

Ala Phe His Met Thr Gln Thr Pro Ala Ser Met Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Met Lys Cys Gln Ala Ser Glu Ser Ile Asp Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gln Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Trp Ser Thr Asn Asp 
                85                  90                  95      


Val Asp Asn Val Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  96
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab6_VL CDRL1

<400>  96
caggccagtg agagcattga tacctactta aac                                    33


<210>  97
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab6_VL CDRL1

<400>  97

Gln Ala Ser Glu Ser Ile Asp Thr Tyr Leu Asn 
1               5                   10      


<210>  98
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab6_VL CDRL2

<400>  98
caggcatcca aactggcatc t                                                 21


<210>  99
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab6_VL CDRL2

<400>  99

Gln Ala Ser Lys Leu Ala Ser 
1               5           


<210>  100
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab6_VL CDRL3

<400>  100
caacagggtt ggagtactaa tgatgttgat aatgtt                                 36


<210>  101
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab6_VL CDRL3

<400>  101

Gln Gln Gly Trp Ser Thr Asn Asp Val Asp Asn Val 
1               5                   10          


<210>  102
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab7_VH VH

<400>  102
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagtcgc tatgcaatgg gctgggtccg ccacgttcca      120

gggaaggggc tggaatggat cggaatcatt tatgctagtg gtagcacata ctacgcgagc      180

tgggcgaagg gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gatcgcgtac tgctacttat      300

gatgctgttg atccctgggg cccgggcacc ctcgtcaccg tctcgagc                   348


<210>  103
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab7_VH VH

<400>  103

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr Ala 
            20                  25                  30          


Met Gly Trp Val Arg His Val Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Tyr Ala Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ser Arg 
                85                  90                  95      


Thr Ala Thr Tyr Asp Ala Val Asp Pro Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  104
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab7_VH CDRH1

<400>  104
cgctatgcaa tgggc                                                        15


<210>  105
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab7_VH CDRH1

<400>  105

Arg Tyr Ala Met Gly 
1               5   


<210>  106
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab7_VH CDRH2

<400>  106
atcatttatg ctagtggtag cacatactac gcgagctggg cgaagggc                    48


<210>  107
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab7_VH CDRH2

<400>  107

Ile Ile Tyr Ala Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  108
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab7_VH CDRH3

<400>  108
tcgcgtactg ctacttatga tgctgttgat ccc                                    33


<210>  109
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab7_VH CDRH3

<400>  109

Ser Arg Thr Ala Thr Tyr Asp Ala Val Asp Pro 
1               5                   10      


<210>  110
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab7_VL VL

<400>  110
gcctatgata tgacccagac tccagcctcc gtgtctgaac ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gagcattagt agttacttat cctggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctacgaa gcatccactc tggcatctgg ggtctcatcg      180

cggttcaaag gcagtggatc tgggacagag tacactctca ccatcagcga cctggagtgt      240

gacgatgctg ccgcttacta ctgtcaacag gatcttagtg gtagtaatct tgataattct      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  111
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab7_VL VL

<400>  111

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Ala Tyr Tyr Cys Gln Gln Asp Leu Ser Gly Ser Asn 
                85                  90                  95      


Leu Asp Asn Ser Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  112
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab7_VL CDRL1

<400>  112
caggccagtc agagcattag tagttactta tcc                                    33


<210>  113
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab7_VL CDRL1

<400>  113

Gln Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ser 
1               5                   10      


<210>  114
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab7_VL CDRL2

<400>  114
gaagcatcca ctctggcatc t                                                 21


<210>  115
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab7_VL CDRL2

<400>  115

Glu Ala Ser Thr Leu Ala Ser 
1               5           


<210>  116
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab7_VL CDRL3

<400>  116
caacaggatc ttagtggtag taatcttgat aattct                                 36


<210>  117
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab7_VL CDRL3

<400>  117

Gln Gln Asp Leu Ser Gly Ser Asn Leu Asp Asn Ser 
1               5                   10          


<210>  118
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab8_VH VH

<400>  118
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgctccgtct ctggaatcga cctcagtagc tatgcaatga gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cggagtcatt tatgctagtg gtagcacata ctacgcgagc      180

tgggcgaaag gccgattcac catctccaag acctcgacca cggtggatct gaaaatcacc      240

agtccgacaa ccggggacac ggccacctat ttctgtgtca gagatactac tgcaacttat      300

aactacttta acttgtgggg ccagggcacc ctcgtcaccg tctcgagc                   348


<210>  119
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab8_VH VH

<400>  119

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Ser Val Ser Gly Ile Asp Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Ile Tyr Ala Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Gly Asp Thr Ala Thr Tyr Phe Cys Val Arg Asp Thr 
                85                  90                  95      


Thr Ala Thr Tyr Asn Tyr Phe Asn Leu Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  120
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab8_VH CDRH1

<400>  120
agctatgcaa tgagc                                                        15


<210>  121
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab8_VH CDRH1

<400>  121

Ser Tyr Ala Met Ser 
1               5   


<210>  122
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab8_VH CDRH2

<400>  122
gtcatttatg ctagtggtag cacatactac gcgagctggg cgaaaggc                    48


<210>  123
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab8_VH CDRH2

<400>  123

Val Ile Tyr Ala Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  124
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab8_VH CDRH3

<400>  124
gatactactg caacttataa ctactttaac ttg                                    33


<210>  125
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab8_VH CDRH3

<400>  125

Asp Thr Thr Ala Thr Tyr Asn Tyr Phe Asn Leu 
1               5                   10      


<210>  126
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab8_VL VL

<400>  126
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagccacc       60

atcaagtgcc aggccagtca gagcatttac aactacttag cctggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctatgaa gcatccactc tggcctccgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaacag agtttgagtc ctagtaatgt tggtcgaagg      300

gttttcggcg gagggaccga ggtggtggtc aaacgt                                336


<210>  127
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab8_VL VL

<400>  127

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Ala Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Leu Ser Pro Ser Asn 
                85                  90                  95      


Val Gly Arg Arg Val Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110         


<210>  128
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab8_VL CDRL1

<400>  128
caggccagtc agagcattta caactactta gcc                                    33


<210>  129
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab8_VL CDRL1

<400>  129

Gln Ala Ser Gln Ser Ile Tyr Asn Tyr Leu Ala 
1               5                   10      


<210>  130
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab8_VL CDRL2

<400>  130
gaagcatcca ctctggcctc c                                                 21


<210>  131
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab8_VL CDRL2

<400>  131

Glu Ala Ser Thr Leu Ala Ser 
1               5           


<210>  132
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab8_VL CDRL3

<400>  132
caacagagtt tgagtcctag taatgttggt cgaagggtt                              39


<210>  133
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab8_VL CDRL3

<400>  133

Gln Gln Ser Leu Ser Pro Ser Asn Val Gly Arg Arg Val 
1               5                   10              


<210>  134
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab9_VH VH

<400>  134
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcaataac tatgcaatga actggatccg ccaggctcca      120

gggaagggac tggaatggat cggaatcatt tatggtagtg gtagcacata ctacgcgagc      180

tgggcgaaag gccgattcac cgcctccaaa acctcgacca cggtggatct gaaaatgacc      240

agtctgacaa ccgaggacac ggccacgtat ttctgtgcca gagatgaact agctgctggt      300

attaattact ttaccttgtg gggccaaggg accctggtca ccgtctcgag c               351


<210>  135
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab9_VH VH

<400>  135

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Asn Tyr Ala 
            20                  25                  30          


Met Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Tyr Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ala Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Glu 
                85                  90                  95      


Leu Ala Ala Gly Ile Asn Tyr Phe Thr Leu Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  136
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab9_VH CDRH1

<400>  136
aactatgcaa tgaac                                                        15


<210>  137
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab9_VH CDRH1

<400>  137

Asn Tyr Ala Met Asn 
1               5   


<210>  138
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab9_VH CDRH2

<400>  138
atcatttatg gtagtggtag cacatactac gcgagctggg cgaaaggc                    48


<210>  139
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab9_VH CDRH2

<400>  139

Ile Ile Tyr Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  140
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab9_VH CDRH3

<400>  140
gatgaactag ctgctggtat taattacttt accttg                                 36


<210>  141
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab9_VH CDRH3

<400>  141

Asp Glu Leu Ala Ala Gly Ile Asn Tyr Phe Thr Leu 
1               5                   10          


<210>  142
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab9_VL VL

<400>  142
gcccttgtga tgacccagac tccagcctcc gtggaggtag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gaatattatt gattggtgct cctggtatca gcagaaacta      120

gggcagcctc ccaaactcct gatctacgaa gcatctaaac tggcatctgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggacacag ttcactctca ccatcagcgg cgtggagtgt      240

gccgatgctg ccacttacta ttgtcaacag ggttatagtc ctagtggtgt tgataatgtt      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  143
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab9_VL VL

<400>  143

Ala Leu Val Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Asn Ile Ile Asp Trp 
            20                  25                  30          


Cys Ser Trp Tyr Gln Gln Lys Leu Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Pro Ser Gly 
                85                  90                  95      


Val Asp Asn Val Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  144
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab9_VL CDRL1

<400>  144
caggccagtc agaatattat tgattggtgc tcc                                    33


<210>  145
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab9_VL CDRL1

<400>  145

Gln Ala Ser Gln Asn Ile Ile Asp Trp Cys Ser 
1               5                   10      


<210>  146
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab9_VL CDRL2

<400>  146
gaagcatcta aactggcatc t                                                 21


<210>  147
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab9_VL CDRL2

<400>  147

Glu Ala Ser Lys Leu Ala Ser 
1               5           


<210>  148
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab9_VL CDRL3

<400>  148
caacagggtt atagtcctag tggtgttgat aatgtt                                 36


<210>  149
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab9_VL CDRL3

<400>  149

Gln Gln Gly Tyr Ser Pro Ser Gly Val Asp Asn Val 
1               5                   10          


<210>  150
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab10_VH VH

<400>  150
cagtcgctgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcga cctcagtagc tatgcagtgg gctgggtccg ccaggctcca      120

gggaaggggc tggaatacat cggaatcatt tatgctagtg gtaacacatg gtacgcgagc      180

tgggtgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatgacc      240

agtctgacaa ccgaggacac ggccacctat ttctgtgcca gaggtcatgg tgctacttat      300

gactacttta atttgtgggg cccaggcacc ctcgtcaccg tctcgagc                   348


<210>  151
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab10_VH VH

<400>  151

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr Ala 
            20                  25                  30          


Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Ile Ile Tyr Ala Ser Gly Asn Thr Trp Tyr Ala Ser Trp Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly His 
                85                  90                  95      


Gly Ala Thr Tyr Asp Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  152
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab10_VH CDRH1

<400>  152
agctatgcag tgggc                                                        15


<210>  153
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab10_VH CDRH1

<400>  153

Ser Tyr Ala Val Gly 
1               5   


<210>  154
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab10_VH CDRH2

<400>  154
atcatttatg ctagtggtaa cacatggtac gcgagctggg tgaaaggc                    48


<210>  155
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab10_VH CDRH2

<400>  155

Ile Ile Tyr Ala Ser Gly Asn Thr Trp Tyr Ala Ser Trp Val Lys Gly 
1               5                   10                  15      


<210>  156
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab10_VH CDRH3

<400>  156
ggtcatggtg ctacttatga ctactttaat ttg                                    33


<210>  157
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab10_VH CDRH3

<400>  157

Gly His Gly Ala Thr Tyr Asp Tyr Phe Asn Leu 
1               5                   10      


<210>  158
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AB10_VL VL

<400>  158
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gagcattagc agttggttag cctggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctatgat gcatccgatc tggcatctgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggacagag tacactctca ccatcagcgg cgtgcagtgt      240

gacgatgctg ccacttacta ctgtcaacag ggtcttgcta ctgctaatgt tgataatgtt      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  159
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB10_VL VL

<400>  159

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Gly Val Gln Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Leu Ala Thr Ala Asn 
                85                  90                  95      


Val Asp Asn Val Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  160
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AB10_VL CDRL1

<400>  160
caggccagtc agagcattag cagttggtta gcc                                    33


<210>  161
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB10_VL CDRL1

<400>  161

Gln Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  162
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AB10_VL CDRL2

<400>  162
gatgcatccg atctggcatc t                                                 21


<210>  163
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB10_VL CDRL2

<400>  163

Asp Ala Ser Asp Leu Ala Ser 
1               5           


<210>  164
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AB10_VL CDRL3

<400>  164
caacagggtc ttgctactgc taatgttgat aatgtt                                 36


<210>  165
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB10_VL CDRL3

<400>  165

Gln Gln Gly Leu Ala Thr Ala Asn Val Asp Asn Val 
1               5                   10          


<210>  166
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab11_VH VH

<400>  166
cagtcgttgg aggagtccgg gggaggcctg gtcaagcctg gaggaaccct gacactcacc       60

tgcacagcct ctggattctc cttcagtagc agctactgga tatgctgggt ccgccaggct      120

ccagggaagg ggctggagtg gatcggatgc atttacggaa gtactgatgc ctataacgcg      180

aactgggcga aaggccgatt cgccatctcc caaacctcgt cgaccacggt gactctgcaa      240

atgaccagtc tgccagccgc ggacacggcc acctatttct gtgcgcgaca tgatggtgat      300

attggttgga ccttggactt gtggggcccg gggaccctgg tcaccgtctc gagc            354


<210>  167
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab11_VH VH

<400>  167

Gln Ser Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr 
            20                  25                  30          


Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Cys Ile Tyr Gly Ser Thr Asp Ala Tyr Asn Ala Asn Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Ala Ile Ser Gln Thr Ser Ser Thr Thr Val Thr Leu Gln 
65                  70                  75                  80  


Met Thr Ser Leu Pro Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


His Asp Gly Asp Ile Gly Trp Thr Leu Asp Leu Trp Gly Pro Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  168
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab11_VH CDRH1

<400>  168
agcagctact ggatatgc                                                     18


<210>  169
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab11_VH CDRH1

<400>  169

Ser Ser Tyr Trp Ile Cys 
1               5       


<210>  170
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab11_VH CDRH2

<400>  170
tgcatttacg gaagtactga tgcctataac gcgaactggg cgaaaggc                    48


<210>  171
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab11_VH CDRH2

<400>  171

Cys Ile Tyr Gly Ser Thr Asp Ala Tyr Asn Ala Asn Trp Ala Lys Gly 
1               5                   10                  15      


<210>  172
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab11_VH CDRH3

<400>  172
catgatggtg atattggttg gaccttggac ttg                                    33


<210>  173
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab11_VH CDRH3

<400>  173

His Asp Gly Asp Ile Gly Trp Thr Leu Asp Leu 
1               5                   10      


<210>  174
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab11_VL VL

<400>  174
gcctatgata tgacccagac tccagcctct gtggaggtcg ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtct gaccattggt actcggttag cctggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctacaag gcatccactc tggcatctgg ggtctcatcg      180

cggttcaaag gcagtggatc tgggacacag ttcgctctca ccatcagcga cctggaatgt      240

gccgatgctg ccacttacta ctgtcaacag gctgcttatg ttactgatat agataatgct      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  175
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab11_VL VL

<400>  175

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Leu Thr Ile Gly Thr Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ala Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ala Ala Tyr Val Thr Asp 
                85                  90                  95      


Ile Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  176
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab11_VL CDRL1

<400>  176
caggccagtc tgaccattgg tactcggtta gcc                                    33


<210>  177
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab11_VL CDRL1

<400>  177

Gln Ala Ser Leu Thr Ile Gly Thr Arg Leu Ala 
1               5                   10      


<210>  178
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab11_VL CDRL2

<400>  178
aaggcatcca ctctggcatc t                                                 21


<210>  179
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab11_VL CDRL2

<400>  179

Lys Ala Ser Thr Leu Ala Ser 
1               5           


<210>  180
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab11_VL CDRL3

<400>  180
caacaggctg cttatgttac tgatatagat aatgct                                 36


<210>  181
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab11_VL CDRL3

<400>  181

Gln Gln Ala Ala Tyr Val Thr Asp Ile Asp Asn Ala 
1               5                   10          


<210>  182
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab12_VH VH

<400>  182
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggaatcga cctcagtagc aatgcaatgg gctgggtccg ccaggctcca      120

gggaaggggc tggaatggat cgggatcatt tatgctagtg gtaacgcatg gtacgcgaac      180

tgggtgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gggatgctac tgctacttgg      300

gactacttta acttgtgggg ccaaggcacc ctcgtcaccg tctcgagc                   348


<210>  183
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab12_VH VH

<400>  183

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Asn Ala 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Tyr Ala Ser Gly Asn Ala Trp Tyr Ala Asn Trp Val Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Ala 
                85                  90                  95      


Thr Ala Thr Trp Asp Tyr Phe Asn Leu Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  184
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab12_VH CDRH1

<400>  184
agcaatgcaa tgggc                                                        15


<210>  185
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab12_VH CDRH1

<400>  185

Ser Asn Ala Met Gly 
1               5   


<210>  186
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab12_VH CDRH2

<400>  186
atcatttatg ctagtggtaa cgcatggtac gcgaactggg tgaaaggc                    48


<210>  187
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab12_VH CDRH2

<400>  187

Ile Ile Tyr Ala Ser Gly Asn Ala Trp Tyr Ala Asn Trp Val Lys Gly 
1               5                   10                  15      


<210>  188
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab12_VH CDRH3

<400>  188
gatgctactg ctacttggga ctactttaac ttg                                    33


<210>  189
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab12_VH CDRH3

<400>  189

Asp Ala Thr Ala Thr Trp Asp Tyr Phe Asn Leu 
1               5                   10      


<210>  190
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab12_VL VL

<400>  190
gcctatgata tgacccagac tccatcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gagcattagt aattggttat cctggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctacagg gcgtccactc tggcatctgg ggtctcatcg      180

cggttcagcg gcagtggatc tgggacagag ttcactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaacag ggttatagtg ttgctaatgt ggataatgct      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  191
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab12_VL VL

<400>  191

Ala Tyr Asp Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Asn Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Val Ala Asn 
                85                  90                  95      


Val Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  192
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab12_VL CDRL1

<400>  192
caggccagtc agagcattag taattggtta tcc                                    33


<210>  193
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab12_VL CDRL1

<400>  193

Gln Ala Ser Gln Ser Ile Ser Asn Trp Leu Ser 
1               5                   10      


<210>  194
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab12_VL CDRL2

<400>  194
agggcgtcca ctctggcatc t                                                 21


<210>  195
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab12_VL CDRL2

<400>  195

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  196
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab12_VL CDRL3

<400>  196
caacagggtt atagtgttgc taatgtggat aatgct                                 36


<210>  197
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab12_VL CDRL3

<400>  197

Gln Gln Gly Tyr Ser Val Ala Asn Val Asp Asn Ala 
1               5                   10          


<210>  198
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab13_VH VH

<400>  198
cagtcgttgg aggagtccgg gggagacctg gtcaagcctg gggcatccct gacactcacc       60

tgcacagcct ctggattctc cttcagtagc agcgactaca tgtgttgggt ccgccaggct      120

ccagggaagg ggctggagtg gatcggatgc atttatactg gtgatggtac cacatactac      180

gcgagctggg cgaaaggccg attcaccatc tccaaaacct cgtcgaccac ggtgactctg      240

caaatgacca gtctgacagc cgcggacacg gccacctatt tctgtgcgag aggggctggt      300

gttggttctt atggttataa tttgtggggc ccgggcaccc tcgtcaccgt ctcgagc         357


<210>  199
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab13_VH VH

<400>  199

Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser Asp 
            20                  25                  30          


Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Cys Ile Tyr Thr Gly Asp Gly Thr Thr Tyr Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Ala Gly Val Gly Ser Tyr Gly Tyr Asn Leu Trp Gly Pro Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  200
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab13_VH CDRH1

<400>  200
agcagcgact acatgtgt                                                     18


<210>  201
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab13_VH CDRH1

<400>  201

Ser Ser Asp Tyr Met Cys 
1               5       


<210>  202
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab13_VH CDRH2

<400>  202
tgcatttata ctggtgatgg taccacatac tacgcgagct gggcgaaagg c                51


<210>  203
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab13_VH CDRH2

<400>  203

Cys Ile Tyr Thr Gly Asp Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  204
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab13_VH CDRH3

<400>  204
ggggctggtg ttggttctta tggttataat ttg                                    33


<210>  205
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab13_VH CDRH3

<400>  205

Gly Ala Gly Val Gly Ser Tyr Gly Tyr Asn Leu 
1               5                   10      


<210>  206
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab13_VL VL

<400>  206
gttgacattg tgatgaccca gactccagcc tccgtggagg cagctgtggg agacacagtc       60

accatcaatt gccaggccag tcagaacatt tacagcaatt tagcctggta tcaacagaaa      120

ccagggcagc ctcccaagct cctgatctac agggcatcca ctctggcatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa agctattatg cgagtagtat tagtaattat      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  207
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab13_VL VL

<400>  207

Val Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Asp Thr Val Thr Ile Asn Cys Gln Ala Ser Gln Asn Ile Tyr Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Ala Ser Ser 
                85                  90                  95      


Ile Ser Asn Tyr Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  208
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab13_VL CDRL1

<400>  208
caggccagtc agaacattta cagcaattta gcc                                    33


<210>  209
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab13_VL CDRL1

<400>  209

Gln Ala Ser Gln Asn Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  210
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab13_VL CDRL2

<400>  210
agggcatcca ctctggcatc t                                                 21


<210>  211
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab13_VL CDRL2

<400>  211

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  212
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab13_VL CDRL3

<400>  212
caaagctatt atgcgagtag tattagtaat tat                                    33


<210>  213
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab13_VL CDRL3

<400>  213

Gln Ser Tyr Tyr Ala Ser Ser Ile Ser Asn Tyr 
1               5                   10      


<210>  214
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab14_VH VH

<400>  214
cagcagcagc tggaggagtc cgggggaggc ctggtcaagc ctggaggaac cctgacactc       60

acctgcaaag gctctggaat cgacttcaat gattactact acatgtgctg ggtccgccag      120

gctccaggga aggggctgga gtggatcgcg tgcatttata atggtgatgg tgagacttac      180

tacgcgaact gggcgaaagg ccgattcacc atctccaaaa cctcgtcgac cacggtgact      240

ctgcagatga ccagtctgac agccgcggac acggccacct atttctgtgc gaggggtagt      300

ggtgttggga gttatggtta caacttttgg ggccagggga ccctggtcac cgtctcgagc      360


<210>  215
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab14_VH VH

<400>  215

Gln Gln Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Lys Gly Ser Gly Ile Asp Phe Asn Asp Tyr 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Tyr Asn Gly Asp Gly Glu Thr Tyr Tyr Ala Asn Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Val Gly Ser Tyr Gly Tyr Asn Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  216
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab14_VH CDRH1

<400>  216
gattactact acatgtgc                                                     18


<210>  217
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab14_VH CDRH1

<400>  217

Asp Tyr Tyr Tyr Met Cys 
1               5       


<210>  218
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab14_VH CDRH2

<400>  218
tgcatttata atggtgatgg tgagacttac tacgcgaact gggcgaaagg c                51


<210>  219
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab14_VH CDRH2

<400>  219

Cys Ile Tyr Asn Gly Asp Gly Glu Thr Tyr Tyr Ala Asn Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  220
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab14_VH CDRH3

<400>  220
ggtagtggtg ttgggagtta tggttacaac ttt                                    33


<210>  221
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab14_VH CDRH3

<400>  221

Gly Ser Gly Val Gly Ser Tyr Gly Tyr Asn Phe 
1               5                   10      


<210>  222
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab14_VL VL

<400>  222
gctgacattg tgatgaccca gactccagcc tccgtggagg cagctgtggg aggcacagtc       60

accatcaagt gccaggccag tgagagcatt tacagcaatt tagcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctaatctac agggcatcca atctggcatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca gagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa ggctattatg ccagtactgt tactaatgct      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  223
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab14_VL VL

<400>  223

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Tyr Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Ala Ser Thr 
                85                  90                  95      


Val Thr Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  224
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab14_VL CDRL1

<400>  224
caggccagtg agagcattta cagcaattta gcc                                    33


<210>  225
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab14_VL CDRL1

<400>  225

Gln Ala Ser Glu Ser Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  226
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab14_VL CDRL2

<400>  226
agggcatcca atctggcatc t                                                 21


<210>  227
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab14_VL CDRL2

<400>  227

Arg Ala Ser Asn Leu Ala Ser 
1               5           


<210>  228
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab14_VL CDRL3

<400>  228
caaggctatt atgccagtac tgttactaat gct                                    33


<210>  229
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab14_VL CDRL3

<400>  229

Gln Gly Tyr Tyr Ala Ser Thr Val Thr Asn Ala 
1               5                   10      


<210>  230
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab15_VH VH

<400>  230
cagcagctgg tggagtccgg gggaggcctg gtcaagcctg gaggaaccct gacactcacc       60

tgcaaaggct ctggaatcga cttcaatgac tactactaca tatgctgggt ccgccaggct      120

ccagggaagg ggctggagtg gatcctatgc atttataatg gcgatggtga gacttactac      180

gcgaactggg cgaaaggccg attcaccatc tccaaaacct cgtcgaccac ggtgactctg      240

cagatgacca gtctgacagg cgcggacacg gccacctatt tctgtgcgag gggtagtggt      300

gttgggagtt atggttacaa cttttggggc caggggaccc tggtcaccgt ctcgagc         357


<210>  231
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab15_VH VH

<400>  231

Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Lys Gly Ser Gly Ile Asp Phe Asn Asp Tyr Tyr 
            20                  25                  30          


Tyr Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Leu Cys Ile Tyr Asn Gly Asp Gly Glu Thr Tyr Tyr Ala Asn Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Thr Gly Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Ser Gly Val Gly Ser Tyr Gly Tyr Asn Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  232
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab15_VH CDRH1

<400>  232
gactactact acatatgc                                                     18


<210>  233
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab15_VH CDRH1

<400>  233

Asp Tyr Tyr Tyr Ile Cys 
1               5       


<210>  234
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab15_VH CDRH2

<400>  234
tgcatttata atggcgatgg tgagacttac tacgcgaact gggcgaaagg c                51


<210>  235
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab15_VH CDRH2

<400>  235

Cys Ile Tyr Asn Gly Asp Gly Glu Thr Tyr Tyr Ala Asn Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  236
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab15_VH CDRH3

<400>  236
ggtagtggtg ttgggagtta tggttacaac ttt                                    33


<210>  237
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab15_VH CDRH3

<400>  237

Gly Ser Gly Val Gly Ser Tyr Gly Tyr Asn Phe 
1               5                   10      


<210>  238
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab15_VL VL

<400>  238
gctgacattg tgatgaccca gactccagcc tccgtggagg cagctgtggg aggcacagtc       60

accatcaagt gccaggccag tgagaacatt tacagcaatt tagcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctaatttac agggcatcca atctggcatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca gagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa ggctattatg ccagtactgt tactaatggt      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  239
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab15_VL VL

<400>  239

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Asn Ile Tyr Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Ala Ser Thr 
                85                  90                  95      


Val Thr Asn Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  240
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab15_VL CDRL1

<400>  240
caggccagtg agaacattta cagcaattta gcc                                    33


<210>  241
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab15_VL CDRL1

<400>  241

Gln Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  242
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab15_VL CDRL2

<400>  242
agggcatcca atctggcatc t                                                 21


<210>  243
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab15_VL CDRL2

<400>  243

Arg Ala Ser Asn Leu Ala Ser 
1               5           


<210>  244
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab15_VL CDRL3

<400>  244
caaggctatt atgccagtac tgttactaat ggt                                    33


<210>  245
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab15_VL CDRL3

<400>  245

Gln Gly Tyr Tyr Ala Ser Thr Val Thr Asn Gly 
1               5                   10      


<210>  246
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab16_VH VH

<400>  246
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagcct ctggattcac catcagtagc tattcaatga tctgggtccg ccaggctcca      120

gggaaggggc tggaatccat cggatggatt aatactggtg gtagcgcata ctacgcgaac      180

tgggcaaaag gccgattcac catctccaga acctcgacca cggtggatct gaaaatgacc      240

agtctgacaa ccgaggacac ggccacctat ttctgtgcca gagacaataa ctggtctttt      300

aacttgtggg gccaaggcac cctggtcacc gtctcgagc                             339


<210>  247
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab16_VH VH

<400>  247

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr Ser 
            20                  25                  30          


Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Ser Ile Gly 
        35                  40                  45              


Trp Ile Asn Thr Gly Gly Ser Ala Tyr Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Asn 
                85                  90                  95      


Asn Trp Ser Phe Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  248
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab16_VH CDRH1

<400>  248
agctattcaa tgatc                                                        15


<210>  249
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab16_VH CDRH1

<400>  249

Ser Tyr Ser Met Ile 
1               5   


<210>  250
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab16_VH CDRH2

<400>  250
tggattaata ctggtggtag cgcatactac gcgaactggg caaaaggc                    48


<210>  251
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab16_VH CDRH2

<400>  251

Trp Ile Asn Thr Gly Gly Ser Ala Tyr Tyr Ala Asn Trp Ala Lys Gly 
1               5                   10                  15      


<210>  252
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab16_VH CDRH3

<400>  252
gacaataact ggtcttttaa cttg                                              24


<210>  253
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab16_VH CDRH3

<400>  253

Asp Asn Asn Trp Ser Phe Asn Leu 
1               5               


<210>  254
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AB16_VL VL

<400>  254
gctgacattg tgatgaccca gactccatcc tccgtgtctg cagctgtggg aggcacagtc       60

accatcaagt gccaggccag tcagagcatt ggtactaatt tagcctggta tcagcagaaa      120

tcagggcagc ctcccaagcg cctgacctac agggcatcca atctggaatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca gagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa ggcggttatt atcgtgaggg taatagtccc      300

acttatcctt tcggcggagg gaccgaggtg gtggtcaaac gt                         342


<210>  255
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB16_VL VL

<400>  255

Ala Asp Ile Val Met Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Gly Thr 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Ser Gly Gln Pro Pro Lys Arg Leu 
        35                  40                  45              


Thr Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Arg Glu 
                85                  90                  95      


Gly Asn Ser Pro Thr Tyr Pro Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys Arg 
        


<210>  256
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AB16_VL CDRL1

<400>  256
caggccagtc agagcattgg tactaattta gcc                                    33


<210>  257
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB16_VL CDRL1

<400>  257

Gln Ala Ser Gln Ser Ile Gly Thr Asn Leu Ala 
1               5                   10      


<210>  258
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AB16_VL CDRL2

<400>  258
agggcatcca atctggaatc t                                                 21


<210>  259
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB16_VL CDRL2

<400>  259

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  260
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AB16_VL CDRL3

<400>  260
caaggcggtt attatcgtga gggtaatagt cccacttatc ct                          42


<210>  261
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB16_VL CDRL3

<400>  261

Gln Gly Gly Tyr Tyr Arg Glu Gly Asn Ser Pro Thr Tyr Pro 
1               5                   10                  


<210>  262
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab17_VH VH

<400>  262
cagcggcagc tggaggagtc cgggggaggc ctggtcaagc ctggaggagc cctgacactc       60

acctgcaaag cctctggaat cgacttcagt agctactact acatatgttg ggtccgccag      120

gctccaggga aggggctgga gtggatcgca tgcatttatg ctggtgatgg taccacttac      180

tacgcgacct gggcggaagg ccgattcacc agctccaaaa cctcgtcgac cacggtgact      240

ctgcaaatga ccagtctgac agccgcggac acggccacct atttctgtgc gaggggtagt      300

ggtgttggta gttatggtta caacttgtgg ggccaaggca ccctcgtcac cgtctcgagc      360


<210>  263
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab17_VH VH

<400>  263

Gln Arg Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ala Leu Thr Leu Thr Cys Lys Ala Ser Gly Ile Asp Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Tyr Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Tyr Ala Gly Asp Gly Thr Thr Tyr Tyr Ala Thr Trp 
    50                  55                  60                  


Ala Glu Gly Arg Phe Thr Ser Ser Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Val Gly Ser Tyr Gly Tyr Asn Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  264
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab17_VH CDRH1

<400>  264
agctactact acatatgt                                                     18


<210>  265
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab17_VH CDRH1

<400>  265

Ser Tyr Tyr Tyr Ile Cys 
1               5       


<210>  266
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab17_VH CDRH2

<400>  266
tgcatttatg ctggtgatgg taccacttac tacgcgacct gggcggaagg c                51


<210>  267
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab17_VH CDRH2

<400>  267

Cys Ile Tyr Ala Gly Asp Gly Thr Thr Tyr Tyr Ala Thr Trp Ala Glu 
1               5                   10                  15      


Gly 
    


<210>  268
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab17_VH CDRH3

<400>  268
ggtagtggtg ttggtagtta tggttacaac ttg                                    33


<210>  269
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab17_VH CDRH3

<400>  269

Gly Ser Gly Val Gly Ser Tyr Gly Tyr Asn Leu 
1               5                   10      


<210>  270
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab17_VL VL

<400>  270
gctgacattg tgatgaccca gactccagcc tccgtggagg cagctgtggg aggcacagtc       60

accatcaagt gccaggccag tgagtacatt tatagcaatt tagcctggta tcagcaaaaa      120

ccagggcagc ctcccaagct cctgatctac agggcatcca ctctggaatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca gagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa ggctattttc ccagtattat tactaatgct      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  271
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab17_VL VL

<400>  271

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Tyr Ile Tyr Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Pro Ser Ile 
                85                  90                  95      


Ile Thr Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  272
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab17_VL CDRL1

<400>  272
caggccagtg agtacattta tagcaattta gcc                                    33


<210>  273
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab17_VL CDRL1

<400>  273

Gln Ala Ser Glu Tyr Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  274
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab17_VL CDRL2

<400>  274
agggcatcca ctctggaatc t                                                 21


<210>  275
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab17_VL CDRL2

<400>  275

Arg Ala Ser Thr Leu Glu Ser 
1               5           


<210>  276
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab17_VL CDRL3

<400>  276
caaggctatt ttcccagtat tattactaat gct                                    33


<210>  277
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab17_VL CDRL3

<400>  277

Gln Gly Tyr Phe Pro Ser Ile Ile Thr Asn Ala 
1               5                   10      


<210>  278
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab18_VH VH

<400>  278
cagcagcagc tggaggagtc cgggggaggc ctggtcaagc ctggaggaac cctgacactc       60

acctgcaaag cctctggatt agacttcagt aactaccact acatgtgctg ggtccgccag      120

gctccaggga agaggcctga gtggatcgca tgcatttata atggtgatgg taccacttac      180

gacgcgagct gggcgaaagg ccgattcacc agctccaaaa cctcgtcgac cacggtgact      240

ctgcaaatga ccagtctgac agccgcggac acggccacct atttctgtgc gaggggtagt      300

ggtgttggta gttatggtta caacttgtgg ggccaaggca ccctcgtcac cgtctcgagc      360


<210>  279
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab18_VH VH

<400>  279

Gln Gln Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Lys Ala Ser Gly Leu Asp Phe Ser Asn Tyr 
            20                  25                  30          


His Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Arg Pro Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Tyr Asn Gly Asp Gly Thr Thr Tyr Asp Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ser Ser Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Val Gly Ser Tyr Gly Tyr Asn Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  280
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab18_VH CDRH1

<400>  280
aactaccact acatgtgc                                                     18


<210>  281
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab18_VH CDRH1

<400>  281

Asn Tyr His Tyr Met Cys 
1               5       


<210>  282
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab18_VH CDRH2

<400>  282
tgcatttata atggtgatgg taccacttac gacgcgagct gggcgaaagg c                51


<210>  283
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab18_VH CDRH2

<400>  283

Cys Ile Tyr Asn Gly Asp Gly Thr Thr Tyr Asp Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  284
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab18_VH CDRH3

<400>  284
ggtagtggtg ttggtagtta tggttacaac ttg                                    33


<210>  285
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab18_VH CDRH3

<400>  285

Gly Ser Gly Val Gly Ser Tyr Gly Tyr Asn Leu 
1               5                   10      


<210>  286
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab18_VL VL

<400>  286
gctgacattg tgatgaccca gactccagcc tccgtggagg cagctgtggg aggcacagtc       60

accatcaagt gccaggccag tgagagcatt tatagcaatt tagcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctgatctac agggcatcca ctctggaatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca gagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa ggctattatg ccagtattat tactaatgct      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  287
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab18_VL VL

<400>  287

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Tyr Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Ala Ser Ile 
                85                  90                  95      


Ile Thr Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  288
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab18_VL CDRL1

<400>  288
caggccagtg agagcattta tagcaattta gcc                                    33


<210>  289
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab18_VL CDRL1

<400>  289

Gln Ala Ser Glu Ser Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  290
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab18_VL CDRL2

<400>  290
agggcatcca ctctggaatc t                                                 21


<210>  291
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab18_VL CDRL2

<400>  291

Arg Ala Ser Thr Leu Glu Ser 
1               5           


<210>  292
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab18_VL CDRL3

<400>  292
caaggctatt atgccagtat tattactaat gct                                    33


<210>  293
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab18_VL CDRL3

<400>  293

Gln Gly Tyr Tyr Ala Ser Ile Ile Thr Asn Ala 
1               5                   10      


<210>  294
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab19_VH VH

<400>  294
caggagcagc tggaggagtc cgggggagac ctggtcaagc ctgagggatc cctgacactc       60

acctgcacag cctctggatt ctccttcagt aactactact acatgtgctg ggtccgccag      120

gctccaggga aggggctgga gtggatcgca tgcatttata ctagtagtgg tagcacttac      180

tacgcgaact gggtgaatgg ccgattcacc atctccagaa gcaccagcct aaacacggtg      240

actctgcaag tgaccagtct gacagccgcg gacacggcca cctatttctg tgcgaaatct      300

tttggtgttg gtggttactc ctttaacttg tggggccaag gcaccctggt caccgtctcg      360

agc                                                                    363


<210>  295
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab19_VH VH

<400>  295

Gln Glu Gln Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Asn Tyr 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Tyr Thr Ser Ser Gly Ser Thr Tyr Tyr Ala Asn Trp 
    50                  55                  60                  


Val Asn Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Leu Asn Thr Val 
65                  70                  75                  80  


Thr Leu Gln Val Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Lys Ser Phe Gly Val Gly Gly Tyr Ser Phe Asn Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  296
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab19_VH CDRH1

<400>  296
aactactact acatgtgc                                                     18


<210>  297
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab19_VH CDRH1

<400>  297

Asn Tyr Tyr Tyr Met Cys 
1               5       


<210>  298
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab19_VH CDRH2

<400>  298
tgcatttata ctagtagtgg tagcacttac tacgcgaact gggtgaatgg c                51


<210>  299
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab19_VH CDRH2

<400>  299

Cys Ile Tyr Thr Ser Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Val Asn 
1               5                   10                  15      


Gly 
    


<210>  300
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab19_VH CDRH3

<400>  300
tcttttggtg ttggtggtta ctcctttaac ttg                                    33


<210>  301
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab19_VH CDRH3

<400>  301

Ser Phe Gly Val Gly Gly Tyr Ser Phe Asn Leu 
1               5                   10      


<210>  302
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab19_VL VL

<400>  302
gcctatgata tgacccagac tccagcctct gtggaggtag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gagtattagt agctacttat cctggtatca gcagaaacca      120

gggcagcgtc ccaagctcct gatctacagg gcatccactc tggcatctgg ggtctcatcg      180

cggttcaaag gcagtggatc tgggacagag tacagtctct ccatcagcgg catggagtgt      240

gacgatgctg ccacttacta ctgtcagcag ggtactacta ttagtgatgt tgataatgtt      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  303
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab19_VL VL

<400>  303

Ala Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Ser Leu Ser Ile Ser Gly Met Glu Cys 
65                  70                  75                  80  


Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Gly Thr Thr Ile Ser Asp 
                85                  90                  95      


Val Asp Asn Val Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  304
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab19_VL CDRL1

<400>  304
caggccagtc agagtattag tagctactta tcc                                    33


<210>  305
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab19_VL CDRL1

<400>  305

Gln Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ser 
1               5                   10      


<210>  306
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab19_VL CDRL2

<400>  306
agggcatcca ctctggcatc t                                                 21


<210>  307
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab19_VL CDRL2

<400>  307

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  308
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab19_VL CDRL3

<400>  308
cagcagggta ctactattag tgatgttgat aatgtt                                 36


<210>  309
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab19_VL CDRL3

<400>  309

Gln Gln Gly Thr Thr Ile Ser Asp Val Asp Asn Val 
1               5                   10          


<210>  310
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab20_VH VH

<400>  310
cagtcggtgg aggagtccgg gggtcgcctg gtcacgcctg ggacacccct gacactcacc       60

tgcacagtct ctggattctc cctcagtgat tatggattga actgggtccg ccaggctcca      120

gggaaggggc tggagtggat cggaatcatt tatgctagtg gtagcacata ctacgcgaac      180

tgggcgaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatgacc      240

agtccgacaa ccgaggacac ggccacctat ttctgtgtca gagatagttc tgctacttat      300

gactacttta acttgtgggg cccgggcacc ctggtcaccg tctcgagc                   348


<210>  311
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab20_VH VH

<400>  311

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asp Tyr Gly 
            20                  25                  30          


Leu Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Tyr Ala Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Val Arg Asp Ser 
                85                  90                  95      


Ser Ala Thr Tyr Asp Tyr Phe Asn Leu Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  312
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab20_VH CDRH1

<400>  312
gattatggat tgaac                                                        15


<210>  313
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab20_VH CDRH1

<400>  313

Asp Tyr Gly Leu Asn 
1               5   


<210>  314
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab20_VH CDRH2

<400>  314
atcatttatg ctagtggtag cacatactac gcgaactggg cgaaaggc                    48


<210>  315
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab20_VH CDRH2

<400>  315

Ile Ile Tyr Ala Ser Gly Ser Thr Tyr Tyr Ala Asn Trp Ala Lys Gly 
1               5                   10                  15      


<210>  316
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab20_VH CDRH3

<400>  316
gatagttctg ctacttatga ctactttaac ttg                                    33


<210>  317
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab20_VH CDRH3

<400>  317

Asp Ser Ser Ala Thr Tyr Asp Tyr Phe Asn Leu 
1               5                   10      


<210>  318
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab20_VL VL

<400>  318
tatgatatga cccagactcc agcctctgtg gaggtagctg tgggaggcac agtcaccatc       60

aagtgccagg ccagtcagag cattagtagc tacttagcct ggtatcagca gaaaccgggg      120

cagcctcccc ggctcctgat ctatggtgca tccaatctgg cgtctggggt cccatcgcgg      180

ttcaaaggca gtggatctgg gacagagtac actctcacca tcagcgacct ggagtgtgcc      240

gatgctgcca cttactactg tcaacaagcc ttgagtccta gtaatgttga taatgctttc      300

ggcggaggga ccgaggtggt ggtcaaacgt                                       330


<210>  319
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab20_VL VL

<400>  319

Tyr Asp Met Thr Gln Thr Pro Ala Ser Val Glu Val Ala Val Gly Gly 
1               5                   10                  15      


Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr Leu 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Gly Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys Ala 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ala Leu Ser Pro Ser Asn Val 
                85                  90                  95      


Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110 


<210>  320
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab20_VL CDRL1

<400>  320
caggccagtc agagcattag tagctactta gcc                                    33


<210>  321
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab20_VL CDRL1

<400>  321

Gln Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  322
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab20_VL CDRL2

<400>  322
ggtgcatcca atctggcgtc t                                                 21


<210>  323
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab20_VL CDRL2

<400>  323

Gly Ala Ser Asn Leu Ala Ser 
1               5           


<210>  324
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab20_VL CDRL3

<400>  324
caacaagcct tgagtcctag taatgttgat aatgct                                 36


<210>  325
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab20_VL CDRL3

<400>  325

Gln Gln Ala Leu Ser Pro Ser Asn Val Asp Asn Ala 
1               5                   10          


<210>  326
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab21_VH VH

<400>  326
cagtcgttgg aggagtccgg gggaggcctg gtccagcctg gggcatccct gacactcacc       60

tgcacagctt ctggattctc cttcagtagc aactactgga tatgctgggt ccgccaggct      120

ccagggaagg ggctggagtg gatcggatgc atttatactg gtactggtat cacatggtac      180

gcgagctggg tgaatggccg agtcaccatc tccagcacct cgtcgaccac ggtgactctg      240

caagtgaaca gtctgacagc cgcggacacg gccacttatt tctgtgcgag aggaagtggt      300

gatatcgcct gggcttggga tttgtggggc caaggcaccc tggtcaccgt ctcgagc         357


<210>  327
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab21_VH VH

<400>  327

Gln Ser Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Ala Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Asn Tyr 
            20                  25                  30          


Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Cys Ile Tyr Thr Gly Thr Gly Ile Thr Trp Tyr Ala Ser Trp Val 
    50                  55                  60                  


Asn Gly Arg Val Thr Ile Ser Ser Thr Ser Ser Thr Thr Val Thr Leu 
65                  70                  75                  80  


Gln Val Asn Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Ser Gly Asp Ile Ala Trp Ala Trp Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  328
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab21_VH CDRH1

<400>  328
agcaactact ggatatgc                                                     18


<210>  329
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab21_VH CDRH1

<400>  329

Ser Asn Tyr Trp Ile Cys 
1               5       


<210>  330
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab21_VH CDRH2

<400>  330
tgcatttata ctggtactgg tatcacatgg tacgcgagct gggtgaatgg c                51


<210>  331
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab21_VH CDRH2

<400>  331

Cys Ile Tyr Thr Gly Thr Gly Ile Thr Trp Tyr Ala Ser Trp Val Asn 
1               5                   10                  15      


Gly 
    


<210>  332
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab21_VH CDRH3

<400>  332
ggaagtggtg atatcgcctg ggcttgggat ttg                                    33


<210>  333
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab21_VH CDRH3

<400>  333

Gly Ser Gly Asp Ile Ala Trp Ala Trp Asp Leu 
1               5                   10      


<210>  334
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab21_VL VL

<400>  334
gatgttgtga tgacccagac tccagcctcc gtgtctgcag ctgtgggagg cacagtcacc       60

atcaagtgcc aggccagtca gagcatttat accaatttag cctggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctacaag gcatccactc tggcatctgg ggtctcatcg      180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcagcgg cgtgcagtgt      240

gccgatgcag ccacttacta ctgtcaatgt actggttatg gtagtagtgg atggactttc      300

ggcggaggga ccgaggtggt ggtcaaacgt                                       330


<210>  335
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab21_VL VL

<400>  335

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Tyr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Val Gln Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Gly Tyr Gly Ser Ser 
                85                  90                  95      


Gly Trp Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110 


<210>  336
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab21_VL CDRL1

<400>  336
caggccagtc agagcattta taccaattta gcc                                    33


<210>  337
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab21_VL CDRL1

<400>  337

Gln Ala Ser Gln Ser Ile Tyr Thr Asn Leu Ala 
1               5                   10      


<210>  338
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab21_VL CDRL2

<400>  338
aaggcatcca ctctggcatc t                                                 21


<210>  339
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab21_VL CDRL2

<400>  339

Lys Ala Ser Thr Leu Ala Ser 
1               5           


<210>  340
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab21_VL CDRL3

<400>  340
caatgtactg gttatggtag tagtggatgg act                                    33


<210>  341
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab21_VL CDRL3

<400>  341

Gln Cys Thr Gly Tyr Gly Ser Ser Gly Trp Thr 
1               5                   10      


<210>  342
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab22_VH VH

<400>  342
cagtcgttgg aggagtccgg gggagacctg gtcaagcctg gggcatccct gacactcacc       60

tgcacagcct ctggattctc cttcagtacc agctattaca tgtgctgggt ccgccaggct      120

ccagggaagg ggctggagtg gatcggatgc atacatacta gtacgttttc cacatggtac      180

gcgagctggg cgaaaggccg attcaccatc tccaaaacct cgtcgaccac ggtgactctg      240

caaatgacca gtctgacagc cgcggacacg gccacctatt tctgtgcgag aagagatgct      300

tataattatg ctggttatgc ttataacttg tggggccagg ggaccctggt caccgtctcg      360

agc                                                                    363


<210>  343
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab22_VH VH

<400>  343

Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Thr Ser Tyr 
            20                  25                  30          


Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Cys Ile His Thr Ser Thr Phe Ser Thr Trp Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Arg Asp Ala Tyr Asn Tyr Ala Gly Tyr Ala Tyr Asn Leu Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  344
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab22_VH CDRH1

<400>  344
accagctatt acatgtgc                                                     18


<210>  345
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab22_VH CDRH1

<400>  345

Thr Ser Tyr Tyr Met Cys 
1               5       


<210>  346
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab22_VH CDRH2

<400>  346
tgcatacata ctagtacgtt ttccacatgg tacgcgagct gggcgaaagg c                51


<210>  347
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab22_VH CDRH2

<400>  347

Cys Ile His Thr Ser Thr Phe Ser Thr Trp Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  348
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab22_VH CDRH3

<400>  348
agagatgctt ataattatgc tggttatgct tataacttg                              39


<210>  349
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab22_VH CDRH3

<400>  349

Arg Asp Ala Tyr Asn Tyr Ala Gly Tyr Ala Tyr Asn Leu 
1               5                   10              


<210>  350
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab22_VL VL

<400>  350
gatgttgtga tgacccagac tccagcctcg gtgtctgccg ctgtgggagg cacagtcacc       60

atcaattgcc aggccagtga ggacatttat agcaatttgg cctggtatca gcagaaacca      120

gggcagcctc ccaagctcct gatctatggt gcatccactc tggcatctgg ggtcccatcg      180

cggttcaaag gcagtggatc tgggacagag ttcactctca ccatcagcga cctggagtgt      240

gccgatgctg ccacttacta ctgtcaatgc acttttggtt gttttagtgg tagtagtaac      300

aacattttcg gcggagggac cgaggtggtg gtcaaacgt                             339


<210>  351
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab22_VL VL

<400>  351

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Glu Asp Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Phe Gly Cys Phe Ser 
                85                  90                  95      


Gly Ser Ser Asn Asn Ile Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


Arg 
    


<210>  352
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab22_VL CDRL1

<400>  352
caggccagtg aggacattta tagcaatttg gcc                                    33


<210>  353
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab22_VL CDRL1

<400>  353

Gln Ala Ser Glu Asp Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  354
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab22_VL CDRL2

<400>  354
ggtgcatcca ctctggcatc t                                                 21


<210>  355
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab22_VL CDRL2

<400>  355

Gly Ala Ser Thr Leu Ala Ser 
1               5           


<210>  356
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab22_VL CDRL3

<400>  356
caatgcactt ttggttgttt tagtggtagt agtaacaaca tt                          42


<210>  357
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab22_VL CDRL3

<400>  357

Gln Cys Thr Phe Gly Cys Phe Ser Gly Ser Ser Asn Asn Ile 
1               5                   10                  


<210>  358
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab23_VH VH

<400>  358
cagcagcagc tggaggagtc cgggggaggc ctggtcaagc ctggaggaac cctgacactc       60

acctgcaaag cctctggaat cgacttcaat gactactact acatgtgctg ggtccgccag      120

gctccaggga aggggcctga gtggatcgca tgcatttata atggtgatgg tgacacttac      180

tacgcgaact gggcgaaagg ccgattcacc atctccaaaa cctcgtcgac cacggtgact      240

ctgcaaatga ccagtctgac agccgcggac acggccacct atttctgtgc gaggggtagt      300

ggtgttggta gttatggtta caacttgtgg ggccaaggca ccctggtcac cgtctcgagc      360


<210>  359
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab23_VH VH

<400>  359

Gln Gln Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Lys Ala Ser Gly Ile Asp Phe Asn Asp Tyr 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Tyr Asn Gly Asp Gly Asp Thr Tyr Tyr Ala Asn Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Val Gly Ser Tyr Gly Tyr Asn Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  360
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab23_VH CDRH1

<400>  360
gactactact acatgtgc                                                     18


<210>  361
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab23_VH CDRH1

<400>  361

Asp Tyr Tyr Tyr Met Cys 
1               5       


<210>  362
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab23_VH CDRH2

<400>  362
tgcatttata atggtgatgg tgacacttac tacgcgaact gggcgaaagg c                51


<210>  363
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab23_VH CDRH2

<400>  363

Cys Ile Tyr Asn Gly Asp Gly Asp Thr Tyr Tyr Ala Asn Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  364
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab23_VH CDRH3

<400>  364
ggtagtggtg ttggtagtta tggttacaac ttg                                    33


<210>  365
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab23_VH CDRH3

<400>  365

Gly Ser Gly Val Gly Ser Tyr Gly Tyr Asn Leu 
1               5                   10      


<210>  366
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab23_VL VL

<400>  366
gctgacattg tgatgaccca gactccagcc tccgtggagg cagctgtggg aggcacagtc       60

accatcaagt gccaggccag tgagagcatt tacagcaatt tagcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctaatctac agggcatcta ctctggcatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca gagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa ggctattatg ccagtactat tactaatgtt      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  367
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab23_VL VL

<400>  367

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Tyr Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Ala Ser Thr 
                85                  90                  95      


Ile Thr Asn Val Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  368
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab23_VL CDRL1

<400>  368
caggccagtg agagcattta cagcaattta gcc                                    33


<210>  369
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab23_VL CDRL1

<400>  369

Gln Ala Ser Glu Ser Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  370
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab23_VL CDRL2

<400>  370
agggcatcta ctctggcatc t                                                 21


<210>  371
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab23_VL CDRL2

<400>  371

Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210>  372
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab23_VL CDRL3

<400>  372
caaggctatt atgccagtac tattactaat gtt                                    33


<210>  373
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab23_VL CDRL3

<400>  373

Gln Gly Tyr Tyr Ala Ser Thr Ile Thr Asn Val 
1               5                   10      


<210>  374
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab24_VH VH

<400>  374
cagcagcagc tggaggagtc cgggggaggc ctggtcaagc ctggaggaac cctgacactc       60

acctgcaaag cctctggaat cgacttcagt aacgtctact acatgtgctg ggtccgccag      120

gctccaggga aggggccgga gtggatcgca tgcatttatg ttggtgatgg cagcacatac      180

gacgcgagct gggcgagagg ccgattcacc atctccaaaa cctcgtcgac cacggtgact      240

ctgcagatga ttagtctgac agccgcggac acggccacct atttctgtgc ggggggtact      300

ggtgttggta gctatggtta cagcttgtgg ggcccaggca ccctggtcac cgtctcgagc      360


<210>  375
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab24_VH VH

<400>  375

Gln Gln Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Lys Ala Ser Gly Ile Asp Phe Ser Asn Val 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Tyr Val Gly Asp Gly Ser Thr Tyr Asp Ala Ser Trp 
    50                  55                  60                  


Ala Arg Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Ile Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Gly Gly Thr Gly Val Gly Ser Tyr Gly Tyr Ser Leu Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  376
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab24_VH CDRH1

<400>  376
aacgtctact acatgtgc                                                     18


<210>  377
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab24_VH CDRH1

<400>  377

Asn Val Tyr Tyr Met Cys 
1               5       


<210>  378
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab24_VH CDRH2

<400>  378
tgcatttatg ttggtgatgg cagcacatac gacgcgagct gggcgagagg c                51


<210>  379
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab24_VH CDRH2

<400>  379

Cys Ile Tyr Val Gly Asp Gly Ser Thr Tyr Asp Ala Ser Trp Ala Arg 
1               5                   10                  15      


Gly 
    


<210>  380
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab24_VH CDRH3

<400>  380
ggtactggtg ttggtagcta tggttacagc ttg                                    33


<210>  381
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab24_VH CDRH3

<400>  381

Gly Thr Gly Val Gly Ser Tyr Gly Tyr Ser Leu 
1               5                   10      


<210>  382
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab24_VL VL

<400>  382
gctgacattg tgatgaccca gactccagcc tccgtggagg cagctgtggg aggcacagtc       60

accatcaagt gccaggccag tgagagcatt tatagcaatt tagcctggta tcatcagaaa      120

ccagggcagc ctcccaagct cctgatctac agggcatcca atctggaatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca gatttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa ggctattatg ccagtgttgt tacaaatggt      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  383
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab24_VL VL

<400>  383

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Tyr Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr His Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Ala Ser Val 
                85                  90                  95      


Val Thr Asn Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  384
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab24_VL CDRL1

<400>  384
caggccagtg agagcattta tagcaattta gcc                                    33


<210>  385
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab24_VL CDRL1

<400>  385

Gln Ala Ser Glu Ser Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  386
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab24_VL CDRL2

<400>  386
agggcatcca atctggaatc t                                                 21


<210>  387
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab24_VL CDRL2

<400>  387

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  388
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab24_VL CDRL3

<400>  388
caaggctatt atgccagtgt tgttacaaat ggt                                    33


<210>  389
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab24_VL CDRL3

<400>  389

Gln Gly Tyr Tyr Ala Ser Val Val Thr Asn Gly 
1               5                   10      


<210>  390
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab25_VH VH

<400>  390
cagcggcagc tggaggagtc cgggggaggc ctggtcaagc ctggaggagc cctgacactc       60

acctgcaaag cctctggaat cgacttcagt agctactact acagatgctg ggtccgccag      120

gctccaggga aggggctgga gtggatcgca tgcatttata ctggtgatgg taccacttac      180

tacgcgagct gggcgaaagg ccgattcacc acctccaaaa cctcgtcgac cacggtgact      240

ctgcaaatga ccagtctgac agccgcggac acggccacct atttctgtgc gaggggtagt      300

ggtgttggta gttatggtta caacttctgg ggcccaggca ccctggtcac cgtctcgagc      360


<210>  391
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab25_VH VH

<400>  391

Gln Arg Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ala Leu Thr Leu Thr Cys Lys Ala Ser Gly Ile Asp Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Tyr Arg Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Tyr Thr Gly Asp Gly Thr Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Thr Ser Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Val Gly Ser Tyr Gly Tyr Asn Phe Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  392
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab25_VH CDRH1

<400>  392
agctactact acagatgc                                                     18


<210>  393
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab25_VH CDRH1

<400>  393

Ser Tyr Tyr Tyr Arg Cys 
1               5       


<210>  394
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab25_VH CDRH2

<400>  394
tgcatttata ctggtgatgg taccacttac tacgcgagct gggcgaaagg c                51


<210>  395
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab25_VH CDRH2

<400>  395

Cys Ile Tyr Thr Gly Asp Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  396
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab25_VH CDRH3

<400>  396
ggtagtggtg ttggtagtta tggttacaac ttc                                    33


<210>  397
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab25_VH CDRH3

<400>  397

Gly Ser Gly Val Gly Ser Tyr Gly Tyr Asn Phe 
1               5                   10      


<210>  398
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab25_VL VL

<400>  398
gctgacattg tgatgaccca gactccagcc tccgtggagg cagctgtggg aggcacagtc       60

accatcaagt gccaggccag tgagagcatt tatagcaatt tagcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctgatctac agggcatcca ctctggaatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca gagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa ggctattatg ccagtattat tactaatgct      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  399
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab25_VL VL

<400>  399

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Tyr Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Ala Ser Ile 
                85                  90                  95      


Ile Thr Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  400
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab25_VL CDRL1

<400>  400
caggccagtg agagcattta tagcaattta gcc                                    33


<210>  401
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab25_VL CDRL1

<400>  401

Gln Ala Ser Glu Ser Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  402
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab25_VL CDRL2

<400>  402
agggcatcca ctctggaatc t                                                 21


<210>  403
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab25_VL CDRL2

<400>  403

Arg Ala Ser Thr Leu Glu Ser 
1               5           


<210>  404
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab25_VL CDRL3

<400>  404
caaggctatt atgccagtat tattactaat gct                                    33


<210>  405
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab25_VL CDRL3

<400>  405

Gln Gly Tyr Tyr Ala Ser Ile Ile Thr Asn Ala 
1               5                   10      


<210>  406
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab26_VH VH

<400>  406
cagtcggtgg aggagtccgg gggaggcctg gtcaagcctg agggatccct gacactcacc       60

tgcaaagcct ctggattcga cctcagtagc tactactaca tgtgctgggt ccgccaggct      120

ccagggaagg ggccggagtg gatcgcatgc atttatgctg gtgatggcac cacatactac      180

gcgagctggg cgaaaggccg attcaccatc tccaaaacct cgtcgaccac ggtgactctg      240

caaatgacca gtctgacagc cgcggacacg gccacctatt tctgtgcgag gggtactggt      300

gttggtagct atggttacaa cttgtggggc ccaggcaccc tggtcaccgt ctcgagc         357


<210>  407
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab26_VH VH

<400>  407

Gln Ser Val Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Glu Gly Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Lys Ala Ser Gly Phe Asp Leu Ser Ser Tyr Tyr 
            20                  25                  30          


Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile 
        35                  40                  45              


Ala Cys Ile Tyr Ala Gly Asp Gly Thr Thr Tyr Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Thr Gly Val Gly Ser Tyr Gly Tyr Asn Leu Trp Gly Pro Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  408
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab26_VH CDRH1

<400>  408
agctactact acatgtgc                                                     18


<210>  409
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab26_VH CDRH1

<400>  409

Ser Tyr Tyr Tyr Met Cys 
1               5       


<210>  410
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab26_VH CDRH2

<400>  410
tgcatttatg ctggtgatgg caccacatac tacgcgagct gggcgaaagg c                51


<210>  411
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab26_VH CDRH2

<400>  411

Cys Ile Tyr Ala Gly Asp Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  412
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab26_VH CDRH3

<400>  412
ggtactggtg ttggtagcta tggttacaac ttg                                    33


<210>  413
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab26_VH CDRH3

<400>  413

Gly Thr Gly Val Gly Ser Tyr Gly Tyr Asn Leu 
1               5                   10      


<210>  414
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab26_VL VL

<400>  414
gctgacattg tgatgaccca gactccagcc tccgtggagg cagctgtggg aggcacagtc       60

accatcaagt gccaggccag tgagaacatt tacagcaatt tagcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctaatctac agggcatcca atctggaatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca gagttcactc tcaccatcag cgacctggag      240

tgtgacgatg ctgccactta ctactgtcaa ggctattatc ccagtgctgt tactaatgct      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  415
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab26_VL VL

<400>  415

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Asn Ile Tyr Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Pro Ser Ala 
                85                  90                  95      


Val Thr Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  416
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab26_VL CDRL1

<400>  416
caggccagtg agaacattta cagcaattta gcc                                    33


<210>  417
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab26_VL CDRL1

<400>  417

Gln Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  418
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab26_VL CDRL2

<400>  418
agggcatcca atctggaatc t                                                 21


<210>  419
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab26_VL CDRL2

<400>  419

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  420
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab26_VL CDRL3

<400>  420
caaggctatt atcccagtgc tgttactaat gct                                    33


<210>  421
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab26_VL CDRL3

<400>  421

Gln Gly Tyr Tyr Pro Ser Ala Val Thr Asn Ala 
1               5                   10      


<210>  422
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab27_VH VH

<400>  422
cagtcggtgg aggagtccgg gggaggcctg gtcaagcctg gaggaaccct gacactcacc       60

tgcaaagcct ctggaatcga cttcagtagt taccactaca tgtgctgggt ccgccaggct      120

ccagggaagg ggctggagtg gatcgcgtgc atttataatg gtgatggtga cacttactac      180

gcgagctggg cgaaaggccg attcaccatc tccaaaacct cgtcgaccac ggtgactctg      240

caaatgacca gtctgacagc cgcggacacg gccacctatt tctgtgcgag gggtagtggt      300

gttggtagtt atggttacaa tttgtggggc ccaggcaccc tggtcaccgt ctcgagc         357


<210>  423
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab27_VH VH

<400>  423

Gln Ser Val Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Lys Ala Ser Gly Ile Asp Phe Ser Ser Tyr His 
            20                  25                  30          


Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Cys Ile Tyr Asn Gly Asp Gly Asp Thr Tyr Tyr Ala Ser Trp Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Ser Gly Val Gly Ser Tyr Gly Tyr Asn Leu Trp Gly Pro Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  424
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab27_VH CDRH1

<400>  424
agttaccact acatgtgc                                                     18


<210>  425
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab27_VH CDRH1

<400>  425

Ser Tyr His Tyr Met Cys 
1               5       


<210>  426
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab27_VH CDRH2

<400>  426
tgcatttata atggtgatgg tgacacttac tacgcgagct gggcgaaagg c                51


<210>  427
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab27_VH CDRH2

<400>  427

Cys Ile Tyr Asn Gly Asp Gly Asp Thr Tyr Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  428
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab27_VH CDRH3

<400>  428
ggtagtggtg ttggtagtta tggttacaat ttg                                    33


<210>  429
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab27_VH CDRH3

<400>  429

Gly Ser Gly Val Gly Ser Tyr Gly Tyr Asn Leu 
1               5                   10      


<210>  430
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab27_VL VL

<400>  430
gctgacattg tgatgaccca gactccagcc tccgtggagg cagctgtggg aggcacagtc       60

accatcaagt gccaggccag tgagagcatt tacagcaatt tagcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctaatctac agggcatcca atctggaatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca gagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa ggctattatg ccagtactac tactaatgct      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  431
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab27_VL VL

<400>  431

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Tyr Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Ala Ser Thr 
                85                  90                  95      


Thr Thr Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  432
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab27_VL CDRL1

<400>  432
caggccagtg agagcattta cagcaattta gcc                                    33


<210>  433
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab27_VL CDRL1

<400>  433

Gln Ala Ser Glu Ser Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  434
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab27_VL CDRL2

<400>  434
agggcatcca atctggaatc t                                                 21


<210>  435
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab27_VL CDRL2

<400>  435

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  436
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab27_VL CDRL3

<400>  436
caaggctatt atgccagtac tactactaat gct                                    33


<210>  437
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab27_VL CDRL3

<400>  437

Gln Gly Tyr Tyr Ala Ser Thr Thr Thr Asn Ala 
1               5                   10      


<210>  438
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab28_VH VH

<400>  438
cagcagcagc tggaggagtc cgggggaggc ctggtcaagc ctggaggaac cctgacactc       60

acctgcaaag gctctggaat cgacttcaat gactactact acatgtgctg ggtccgccag      120

gctccaggga aggggctgga gtggatcgca tgcatttata atggtgatgg tgagacttac      180

tacgcgaact gggcgaaagg ccgattcacc atctccaaaa cctcgtcgac cacggtgact      240

ctgcagatga ccagtctgac agccgcggac acggccacct atttctgtgc gaggggtagt      300

ggtgttggga gttatggtta caacttttgg ggcccaggca ccctggtcac cgtctcgagc      360


<210>  439
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab28_VH VH

<400>  439

Gln Gln Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Lys Gly Ser Gly Ile Asp Phe Asn Asp Tyr 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Tyr Asn Gly Asp Gly Glu Thr Tyr Tyr Ala Asn Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Val Gly Ser Tyr Gly Tyr Asn Phe Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  440
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab28_VH CDRH1

<400>  440
gactactact acatgtgc                                                     18


<210>  441
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab28_VH CDRH1

<400>  441

Asp Tyr Tyr Tyr Met Cys 
1               5       


<210>  442
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab28_VH CDRH2

<400>  442
tgcatttata atggtgatgg tgagacttac tacgcgaact gggcgaaagg c                51


<210>  443
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab28_VH CDRH2

<400>  443

Cys Ile Tyr Asn Gly Asp Gly Glu Thr Tyr Tyr Ala Asn Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  444
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab28_VH CDRH3

<400>  444
ggtagtggtg ttgggagtta tggttacaac ttt                                    33


<210>  445
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab28_VH CDRH3

<400>  445

Gly Ser Gly Val Gly Ser Tyr Gly Tyr Asn Phe 
1               5                   10      


<210>  446
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab28_VL VL

<400>  446
gctgacattg tgatgaccca gactccagcc tccgtggagg cagctgtggg aggcacagtc       60

accatcaagt gccaggccag tgagagcatt tacagcaatt tagcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctaatctac agggcatcca atctggcatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca gagttcactc tcaccatcag cgacctggag      240

tgtgccgatg ctgccactta ctactgtcaa ggctattatg ccagtactgt tactaatgct      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  447
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab28_VL VL

<400>  447

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Tyr Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Ala Ser Thr 
                85                  90                  95      


Val Thr Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  448
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab28_VL CDRL1

<400>  448
caggccagtg agagcattta cagcaattta gcc                                    33


<210>  449
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab28_VL CDRL1

<400>  449

Gln Ala Ser Glu Ser Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  450
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab28_VL CDRL2

<400>  450
agggcatcca atctggcatc t                                                 21


<210>  451
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab28_VL CDRL2

<400>  451

Arg Ala Ser Asn Leu Ala Ser 
1               5           


<210>  452
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab28_VL CDRL3

<400>  452
caaggctatt atgccagtac tgttactaat gct                                    33


<210>  453
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab28_VL CDRL3

<400>  453

Gln Gly Tyr Tyr Ala Ser Thr Val Thr Asn Ala 
1               5                   10      


<210>  454
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab29_VH VH

<400>  454
cagcagcagc tggaggagtc cgggggaggc ctggtcaagc ctggaggaac cctgacactc       60

acctgcaaag cctctggaat cgacttcagt agttaccact acatgtgctg ggtccgccag      120

gctccaggga aggggctgga gtggatcgcg tgcatttata atggtgatgg tgacacttac      180

tacgcgagct gggcgaaagg ccgattcacc atctccaaaa cctcgtcgac cacggtgact      240

ctgcaaatga ccagtctgac agccgcggac acggccacct atttctgtgc gaggggtagt      300

ggtgttggta gttatggtta caatttgtgg ggcccaggca ccctggtcac cgtctcgagc      360


<210>  455
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab29_VH VH

<400>  455

Gln Gln Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Lys Ala Ser Gly Ile Asp Phe Ser Ser Tyr 
            20                  25                  30          


His Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Tyr Asn Gly Asp Gly Asp Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Val Gly Ser Tyr Gly Tyr Asn Leu Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  456
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab29_VH CDRH1

<400>  456
agttaccact acatgtgc                                                     18


<210>  457
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab29_VH CDRH1

<400>  457

Ser Tyr His Tyr Met Cys 
1               5       


<210>  458
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab29_VH CDRH2

<400>  458
tgcatttata atggtgatgg tgacacttac tacgcgagct gggcgaaagg c                51


<210>  459
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab29_VH CDRH2

<400>  459

Cys Ile Tyr Asn Gly Asp Gly Asp Thr Tyr Tyr Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  460
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab29_VH CDRH3

<400>  460
ggtagtggtg ttggtagtta tggttacaat ttg                                    33


<210>  461
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab29_VH CDRH3

<400>  461

Gly Ser Gly Val Gly Ser Tyr Gly Tyr Asn Leu 
1               5                   10      


<210>  462
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab29_VL VL

<400>  462
gctgacattg tgatgaccca gactccagcc tccgtggagg cagctgtggg aggcacagtc       60

accatcaagt gccaggccag tgagaacatt tacagcaatt tagcctggta tcagcagaaa      120

ccagggcagc ctcccaagct cctaatctac agggcatcca atctggaatc tggggtccca      180

tcgcggttca aaggcagtgg atctgggaca gagttcactc tcaccatcag cgacctggag      240

tgtgacgatg ctgccactta ctactgtcaa ggctattatc ccagtgctgt tactaatgct      300

ttcggcggag ggaccgaggt ggtggtcaaa cgt                                   333


<210>  463
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab29_VL VL

<400>  463

Ala Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val 
1               5                   10                  15      


Gly Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Glu Asn Ile Tyr Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Lys 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu 
65                  70                  75                  80  


Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Tyr Tyr Pro Ser Ala 
                85                  90                  95      


Val Thr Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys Arg 
            100                 105                 110     


<210>  464
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab29_VL CDRL1

<400>  464
caggccagtg agaacattta cagcaattta gcc                                    33


<210>  465
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab29_VL CDRL1

<400>  465

Gln Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  466
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab29_VL CDRL2

<400>  466
agggcatcca atctggaatc t                                                 21


<210>  467
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab29_VL CDRL2

<400>  467

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  468
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ab29_VL CDRL3

<400>  468
caaggctatt atcccagtgc tgttactaat gct                                    33


<210>  469
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab29_VL CDRL3

<400>  469

Gln Gly Tyr Tyr Pro Ser Ala Val Thr Asn Ala 
1               5                   10      


