                         SEQUENCE LISTING

<110>  Ƽչ޹˾
 
<120>  һǶϿԭ弰Ӧ

<130>  2020

<160>  66    

<170>  PatentIn version 3.3

<210>  1
<211>  117
<212>  PRT
<213>  Artifical

<400>  1

Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn 
1               5                   10                  15      


Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu 
            20                  25                  30          


Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala 
        35                  40                  45              


Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val 
    50                  55                  60                  


Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala 
65                  70                  75                  80  


Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala 
                85                  90                  95      


Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
            100                 105                 110         


Glu Arg Arg Ala Glu 
        115         


<210>  2
<211>  351
<212>  DNA
<213>  Artifical

<400>  2
ccccccacct tctccccagc cctgctcgtg gtgaccgaag gggacaacgc caccttcacc     60

tgcagcttct ccaacacatc ggagagcttc gtgctaaact ggtaccgcat gagccccagc    120

aaccagacgg acaagctggc cgccttcccc gaggaccgca gccagcccgg ccaggactgc    180

cgcttccgtg tcacacaact gcccaacggg cgtgacttcc acatgagcgt ggtcagggcc    240

cggcgcaatg acagcggcac ctacctctgt ggggccatct ccctggcccc caaggcgcag    300

atcaaagaga gcctgcgggc agagctcagg gtgacagaga gaagggcaga a             351


<210>  3
<211>  110
<212>  PRT
<213>  Artifical

<400>  3

Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala 
1               5                   10                  15      


Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn 
            20                  25                  30          


Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe 
        35                  40                  45              


Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr 
    50                  55                  60                  


Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg 
65                  70                  75                  80  


Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro 
                85                  90                  95      


Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110 


<210>  4
<211>  330
<212>  DNA
<213>  Artifical

<400>  4
cccaccttct ccccagccct gctcgtggtg accgaagggg acaacgccac cttcacctgc     60

agcttctcca acacatcgga gagcttcgtg ctaaactggt accgcatgag ccccagcaac    120

cagacggaca agctggccgc cttccccgag gaccgcagcc agcccggcca ggactgccgc    180

ttccgtgtca cacaactgcc caacgggcgt gacttccaca tgagcgtggt cagggcccgg    240

cgcaatgaca gcggcaccta cctctgtggg gccatctccc tggcccccaa ggcgcagatc    300

aaagagagcc tgcgggcaga gctcagggtg                                     330


<210>  5
<211>  121
<212>  PRT
<213>  Artifical

<400>  5

Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro 
1               5                   10                  15      


Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser 
            20                  25                  30          


Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser 
        35                  40                  45              


Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser 
    50                  55                  60                  


Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly 
65                  70                  75                  80  


Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly 
                85                  90                  95      


Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys 
            100                 105                 110         


Glu Ser Leu Arg Ala Glu Leu Arg Val 
        115                 120     


<210>  6
<211>  363
<212>  DNA
<213>  Artifical

<400>  6
ttcttagact ccccagacag gccctggaac ccccccacct tctccccagc cctgctcgtg     60

gtgaccgaag gggacaacgc caccttcacc tgcagcttct ccaacacatc ggagagcttc    120

gtgctaaact ggtaccgcat gagccccagc aaccagacgg acaagctggc cgccttcccc    180

gaggaccgca gccagcccgg ccaggactgc cgcttccgtg tcacacaact gcccaacggg    240

cgtgacttcc acatgagcgt ggtcagggcc cggcgcaatg acagcggcac ctacctctgt    300

ggggccatct ccctggcccc caaggcgcag atcaaagaga gcctgcgggc agagctcagg    360

gtg                                                                  363


<210>  7
<211>  251
<212>  PRT
<213>  Artifical

<400>  7

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Thr 
            20                  25                  30          


Lys Ala Ala Trp Tyr Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Phe Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Ser Arg Leu Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Lys Ser Val Ser Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Gln Tyr Thr Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Gly Ile Leu Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu 
    130                 135                 140                 


Ile Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asp Leu Val Ser 
                165                 170                 175     


Trp Tyr Gln Gln Tyr Pro Gly Gln Ala Pro Arg Leu Ile Ile Tyr Glu 
            180                 185                 190         


Val Ile Lys Arg Pro Ser Gly Ile Ser Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Arg Arg Leu His Gly 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
                245                 250     


<210>  8
<211>  753
<212>  DNA
<213>  Artifical

<400>  8
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc     60

acctgtgcca tctccgggga cagtgtctct agcaccaagg ctgcttggta ctggatcagg    120

cagtcccctt cgagaggcct tgagtggctg ggaaggacat acttccggtc caagtggtat    180

aatgactatg ccgactctgt gaaaagtcga ttaaccatca acccagacac atccaagaac    240

cagttctccc tgcaacttaa gtctgtgagt cccgaggaca cggctgtgta ttactgtgca    300

agagggcaat acactgcttt tgatatctgg ggccaaggga caatggtcac cgtctcttca    360

ggaattctag gatccggtgg cggtggcagc ggcggtggtg gttccggagg cggcggttct    420

cagtctgctc tgattcagcc tgcctccgtg tctgggtccc ctggacagtc gatcactatc    480

tcctgtactg gcaccagtag tgatgttgga ggttatgacc ttgtctcctg gtaccaacag    540

tacccgggcc aagcccccag actcatcatt tatgaggtca ttaagcggcc ctcagggatt    600

tctgatcgct tctctggttc caagtctggc aacacggcct ccctgacaat ctctgggctc    660

caggctgagg acgaggctga ttattattgc tgctcatatg caggtagacg tcttcatggt    720

gtgttcggag gaggcaccca gctgaccgtc ctc                                 753


<210>  9
<211>  245
<212>  PRT
<213>  Artifical

<400>  9

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ile Met Met 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile 
                165                 170                 175     


Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ile 
    210                 215                 220                 


Lys Leu Gly Thr Val Thr Thr Val Asp Tyr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  10
<211>  735
<212>  DNA
<213>  Artifical

<400>  10
cagtccgccc tgacccagcc tgcctccgtg tctggctccc ctggccagtc catcaccatc     60

agctgcaccg gcacctccag cgacgtgggc ggctacaact acgtgtcctg gtatcagcag    120

caccccggca aggcccccaa gctgatgatc tacgacgtgt ccaaccggcc ctccggcgtg    180

tccaacagat tctccggctc caagtccggc aacaccgcct ccctgaccat cagcggactg    240

caggcagagg acgaggccga ctactactgc tcctcctaca cctcctccag caccagagtg    300

ttcggcaccg gcacaaaagt gaccgtgctg ggagggggcg gttccggagg aggcggcagc    360

gggggaggag gtagcgaggt gcagctgctg gaatccggcg gaggactggt gcagcctggc    420

ggctccctga gactgtcttg cgccgcctcc ggcttcacct tctccagcta catcatgatg    480

tgggtgcgac aggcccctgg caagggcctg gaatgggtgt cctccatcta cccctccggc    540

ggcatcacct tctacgccga caccgtgaag ggccggttca ccatctcccg ggacaactcc    600

aagaacaccc tgtacctgca gatgaactcc ctgcgggccg aggacaccgc cgtgtactac    660

tgcgcccgga tcaagctggg caccgtgacc accgtggact actggggcca gggcaccctg    720

gtgacagtgt cctcc                                                     735


<210>  11
<211>  254
<212>  PRT
<213>  Artifical

<400>  11

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Glu Asp Ile Tyr Ser Leu 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Asn Tyr Gly Ser Ser Ser 
                85                  90                  95      


Ser Ser Ser Tyr Gly Ala Val Phe Gly Gln Gly Thr Lys Leu Thr Val 
            100                 105                 110         


Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Val Ser Gly 
145                 150                 155                 160 


Ile Asp Leu Ser Ser Tyr Thr Met Gly Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Val Gly Ile Ile Ser Ser Gly Gly Arg Thr Tyr 
            180                 185                 190         


Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser 
        195                 200                 205             


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Arg Gly Arg Tyr Thr Gly Tyr Pro Tyr Tyr 
225                 230                 235                 240 


Phe Ala Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  12
<211>  21
<212>  PRT
<213>  Artifical

<400>  12

Val Gly Val Val Gly Gly Leu Leu Gly Ser Leu Val Leu Leu Val Trp 
1               5                   10                  15      


Val Leu Ala Val Ile 
            20      


<210>  13
<211>  63
<212>  DNA
<213>  Artifical

<400>  13
gttggtgtcg tgggcggcct gctgggcagc ctggtgctgc tagtctgggt cctggccgtc     60

atc                                                                   63


<210>  14
<211>  24
<212>  PRT
<213>  Artifical

<400>  14

Thr Leu Val Val Gly Val Val Gly Gly Leu Leu Gly Ser Leu Val Leu 
1               5                   10                  15      


Leu Val Trp Val Leu Ala Val Ile 
            20                  


<210>  15
<211>  72
<212>  DNA
<213>  Artifical

<400>  15
accctggtgg ttggtgtcgt gggcggcctg ctgggcagcc tggtgctgct agtctgggtc     60

ctggccgtca tc                                                         72


<210>  16
<211>  20
<212>  PRT
<213>  Artifical

<400>  16

Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe 
1               5                   10                  15      


Gln Thr Leu Val 
            20  


<210>  17
<211>  60
<212>  DNA
<213>  Artifical

<400>  17
gtgcccacag cccaccccag cccctcaccc aggccagccg gccagttcca aaccctggtg     60


<210>  18
<211>  23
<212>  PRT
<213>  Artifical

<400>  18

Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
1               5                   10                  15      


Arg Pro Ala Gly Gln Phe Gln 
            20              


<210>  19
<211>  69
<212>  DNA
<213>  Artifical

<400>  19
acagagagaa gggcagaagt gcccacagcc caccccagcc cctcacccag gccagccggc     60

cagttccaa                                                             69


<210>  20
<211>  20
<212>  PRT
<213>  Artifical

<400>  20

Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
1               5                   10                  15      


Val Leu Asp Lys 
            20  


<210>  21
<211>  60
<212>  DNA
<213>  Artifical

<400>  21
aaccagctct ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag     60


<210>  22
<211>  20
<212>  PRT
<213>  Artifical

<400>  22

Asn Gln Leu Phe Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Phe Asp 
1               5                   10                  15      


Val Leu Asp Lys 
            20  


<210>  23
<211>  60
<212>  DNA
<213>  Artifical

<400>  23
aaccagctct ttaacgagct caatctagga cgaagagagg agttcgatgt tttggacaag     60


<210>  24
<211>  21
<212>  PRT
<213>  Artifical

<400>  24

Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
1               5                   10                  15      


Ser Glu Ile Gly Met 
            20      


<210>  25
<211>  63
<212>  DNA
<213>  Artifical

<400>  25
gaaggcctgt acaatgaact gcagaaagat aagatggcgg aggcctacag tgagattggg     60

atg                                                                   63


<210>  26
<211>  21
<212>  PRT
<213>  Artifical

<400>  26

Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Phe 
1               5                   10                  15      


Ser Glu Ile Gly Met 
            20      


<210>  27
<211>  63
<212>  DNA
<213>  Artifical

<400>  27
gaaggcctgt tcaatgaact gcagaaagat aagatggcgg aggccttcag tgagattggg     60

atg                                                                   63


<210>  28
<211>  20
<212>  PRT
<213>  Artifical

<400>  28

Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
1               5                   10                  15      


Ala Leu His Met 
            20  


<210>  29
<211>  60
<212>  DNA
<213>  Artifical

<400>  29
gatggccttt accagggact cagtacagcc accaaggaca cctacgacgc ccttcacatg     60


<210>  30
<211>  20
<212>  PRT
<213>  Artifical

<400>  30

Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp 
1               5                   10                  15      


Ala Leu His Met 
            20  


<210>  31
<211>  60
<212>  DNA
<213>  Artifical

<400>  31
gatggccttt tccagggact cagtacagcc accaaggaca ccttcgacgc ccttcacatg     60


<210>  32
<211>  20
<212>  PRT
<213>  Artifical

<400>  32

Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser Gly 
1               5                   10                  15      


Leu Asn Gln Arg 
            20  


<210>  33
<211>  60
<212>  DNA
<213>  Artifical

<400>  33
ccagactatg agcccatccg gaaaggccag cgggacctgt attctggcct gaatcagaga     60


<210>  34
<211>  20
<212>  PRT
<213>  Artifical

<400>  34

Pro Asp Phe Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Phe Ser Gly 
1               5                   10                  15      


Leu Asn Gln Arg 
            20  


<210>  35
<211>  60
<212>  DNA
<213>  Artifical

<400>  35
ccagactttg agcccatccg gaaaggccag cgggacctgt tttctggcct gaatcagaga     60


<210>  36
<211>  27
<212>  PRT
<213>  Artifical

<400>  36

Gly Gly Tyr Met Thr Leu Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys 
1               5                   10                  15      


Asn Ile Tyr Leu Thr Leu Pro Pro Asn Gly Thr 
            20                  25          


<210>  37
<211>  81
<212>  DNA
<213>  Artifical

<400>  37
ggcggctaca tgactctgaa ccccagggca cctactgacg atgataaaaa catctacctg     60

actcttcctc ccaacggtac c                                               81


<210>  38
<211>  20
<212>  PRT
<213>  Artifical

<400>  38

Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr 
1               5                   10                  15      


Leu Lys His Glu 
            20  


<210>  39
<211>  60
<212>  DNA
<213>  Artifical

<400>  39
ggtgtttaca cgggcctgag caccaggaac caggagactt acgagactct gaagcatgag     60


<210>  40
<211>  22
<212>  PRT
<213>  Artifical

<400>  40

Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp 
1               5                   10                  15      


Leu Asn Thr Gln Gly Thr 
            20          


<210>  41
<211>  66
<212>  DNA
<213>  Artifical

<400>  41
tcgccttatc aggaactcca gggtcagagg tcggatgtct acagcgacct caacacacag     60

ggtacc                                                                66


<210>  42
<211>  618
<212>  PRT
<213>  Artifical

<400>  42

Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser Arg 
1               5                   10                  15      


Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly Leu 
            20                  25                  30          


Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu Ser 
        35                  40                  45              


Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln Leu 
    50                  55                  60                  


Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro Ala 
65                  70                  75                  80  


Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys Asn 
                85                  90                  95      


Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro Gly 
            100                 105                 110         


Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg Gln 
        115                 120                 125             


Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser Gln 
    130                 135                 140                 


Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg Met 
145                 150                 155                 160 


Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys Leu 
                165                 170                 175     


Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg Lys 
            180                 185                 190         


Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val Tyr 
        195                 200                 205             


His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro Glu 
    210                 215                 220                 


Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys Leu 
225                 230                 235                 240 


Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn Ser 
                245                 250                 255     


Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala His 
            260                 265                 270         


Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn Ser 
        275                 280                 285             


Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys Pro 
    290                 295                 300                 


Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser Asp 
305                 310                 315                 320 


Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn Leu 
                325                 330                 335     


Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val Arg 
            340                 345                 350         


Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile Lys 
        355                 360                 365             


Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met Arg 
    370                 375                 380                 


Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg Leu 
385                 390                 395                 400 


Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met Ala 
                405                 410                 415     


Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu Ile 
            420                 425                 430         


Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly Met 
        435                 440                 445             


Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala Arg 
    450                 455                 460                 


Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe Gly 
465                 470                 475                 480 


Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg Ser 
                485                 490                 495     


Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn Phe 
            500                 505                 510         


Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr Met 
        515                 520                 525             


Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys Gly 
    530                 535                 540                 


Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys Pro 
545                 550                 555                 560 


Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp Ile 
                565                 570                 575     


Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg Met 
            580                 585                 590         


Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro Gly 
        595                 600                 605             


Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615             


<210>  43
<211>  1854
<212>  DNA
<213>  Artifical

<400>  43
ccagaccccg cggcgcacct gcccttcttc tacggcagca tctcgcgtgc cgaggccgag     60

gagcacctga agctggcggg catggcggac gggctcttcc tgctgcgcca gtgcctgcgc    120

tcgctgggcg gctatgtgct gtcgctcgtg cacgatgtgc gcttccacca ctttcccatc    180

gagcgccagc tcaacggcac ctacgccatt gccggcggca aagcgcactg tggaccggca    240

gagctctgcg agttctactc gcgcgacccc gacgggctgc cctgcaacct gcgcaagccg    300

tgcaaccggc cgtcgggcct cgagccgcag ccgggggtct tcgactgcct gcgagacgcc    360

atggtgcgtg actacgtgcg ccagacgtgg aagctggagg gcgaggccct ggagcaggcc    420

atcatcagcc aggccccgca ggtggagaag ctcattgcta cgacggccca cgagcggatg    480

ccctggtacc acagcagcct gacgcgtgag gaggccgagc gcaaacttta ctctggggcg    540

cagaccgacg gcaagttcct gctgaggccg cggaaggagc agggcacata cgccctgtcc    600

ctcatctatg ggaagacggt gtaccactac ctcatcagcc aagacaaggc gggcaagtac    660

tgcattcccg agggcaccaa gtttgacacg ctctggcagc tggtggagta tctgaagctg    720

aaggcggacg ggctcatcta ctgcctgaag gaggcctgcc ccaacagcag tgccagcaac    780

gcctcagggg ctgctgctcc cacactccca gcccacccat ccacgttgac tcatcctcag    840

agacgaatcg acaccctcaa ctcagatgga tacacccctg agccagcacg cataacgtcc    900

ccagacaaac cgcggccgat gcccatggac acgagcgtgt atgagagccc ctacagcgac    960

ccagaggagc tcaaggacaa gaagctcttc ctgaagcgcg ataacctcct catagctgac   1020

attgaacttg gctgcggcaa ctttggctca gtgcgccagg gcgtgtaccg catgcgcaag   1080

aagcagatcg acgtggccat caaggtgctg aagcagggca cggagaaggc agacacggaa   1140

gagatgatgc gcgaggcgca gatcatgcac cagctggaca acccctacat cgtgcggctc   1200

attggcgtct gccaggccga ggccctcatg ctggtcatgg agatggctgg gggcgggccg   1260

ctgcacaagt tcctggtcgg caagagggag gagatccctg tgagcaatgt ggccgagctg   1320

ctgcaccagg tgtccatggg gatgaagtac ctggaggaga agaactttgt gcaccgtgac   1380

ctggcggccc gcaacgtcct gctggttaac cggcactacg ccaagatcag cgactttggc   1440

ctctccaaag cactgggtgc cgacgacagc tactacactg cccgctcagc agggaagtgg   1500

ccgctcaagt ggtacgcacc cgaatgcatc aacttccgca agttctccag ccgcagcgat   1560

gtctggagct atggggtcac catgtgggag gccttgtcct acggccagaa gccctacaag   1620

aagatgaaag ggccggaggt catggccttc atcgagcagg gcaagcggat ggagtgccca   1680

ccagagtgtc cacccgaact gtacgcactc atgagtgact gctggatcta caagtgggag   1740

gatcgccccg acttcctgac cgtggagcag cgcatgcgag cctgttacta cagcctggcc   1800

agcaaggtgg aagggccccc aggcagcaca cagaaggctg aggctgcctg tgcc         1854


<210>  44
<211>  634
<212>  PRT
<213>  Artifical

<400>  44

Ala Ser Ser Gly Met Ala Asp Ser Ala Asn His Leu Pro Phe Phe Phe 
1               5                   10                  15      


Gly Asn Ile Thr Arg Glu Glu Ala Glu Asp Tyr Leu Val Gln Gly Gly 
            20                  25                  30          


Met Ser Asp Gly Leu Tyr Leu Leu Arg Gln Ser Arg Asn Tyr Leu Gly 
        35                  40                  45              


Gly Phe Ala Leu Ser Val Ala His Gly Arg Lys Ala His His Tyr Thr 
    50                  55                  60                  


Ile Glu Arg Glu Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Arg Thr 
65                  70                  75                  80  


His Ala Ser Pro Ala Asp Leu Cys His Tyr His Ser Gln Glu Ser Asp 
                85                  90                  95      


Gly Leu Val Cys Leu Leu Lys Lys Pro Phe Asn Arg Pro Gln Gly Val 
            100                 105                 110         


Gln Pro Lys Thr Gly Pro Phe Glu Asp Leu Lys Glu Asn Leu Ile Arg 
        115                 120                 125             


Glu Tyr Val Lys Gln Thr Trp Asn Leu Gln Gly Gln Ala Leu Glu Gln 
    130                 135                 140                 


Ala Ile Ile Ser Gln Lys Pro Gln Leu Glu Lys Leu Ile Ala Thr Thr 
145                 150                 155                 160 


Ala His Glu Lys Met Pro Trp Phe His Gly Lys Ile Ser Arg Glu Glu 
                165                 170                 175     


Ser Glu Gln Ile Val Leu Ile Gly Ser Lys Thr Asn Gly Lys Phe Leu 
            180                 185                 190         


Ile Arg Ala Arg Asp Asn Asn Gly Ser Tyr Ala Leu Cys Leu Leu His 
        195                 200                 205             


Glu Gly Lys Val Leu His Tyr Arg Ile Asp Lys Asp Lys Thr Gly Lys 
    210                 215                 220                 


Leu Ser Ile Pro Glu Gly Lys Lys Phe Asp Thr Leu Trp Gln Leu Val 
225                 230                 235                 240 


Glu His Tyr Ser Tyr Lys Ala Asp Gly Leu Leu Arg Val Leu Thr Val 
                245                 250                 255     


Pro Cys Gln Lys Ile Gly Thr Gln Gly Asn Val Asn Phe Gly Gly Arg 
            260                 265                 270         


Pro Gln Leu Pro Gly Ser His Pro Ala Thr Trp Ser Ala Gly Gly Ile 
        275                 280                 285             


Ile Ser Arg Ile Lys Ser Tyr Ser Phe Pro Lys Pro Gly His Arg Lys 
    290                 295                 300                 


Ser Ser Pro Ala Gln Gly Asn Arg Gln Glu Ser Thr Val Ser Phe Asn 
305                 310                 315                 320 


Pro Tyr Glu Pro Glu Leu Ala Pro Trp Ala Ala Asp Lys Gly Pro Gln 
                325                 330                 335     


Arg Glu Ala Leu Pro Met Asp Thr Glu Val Tyr Glu Ser Pro Tyr Ala 
            340                 345                 350         


Asp Pro Glu Glu Ile Arg Pro Lys Glu Val Tyr Leu Asp Arg Lys Leu 
        355                 360                 365             


Leu Thr Leu Glu Asp Lys Glu Leu Gly Ser Gly Asn Phe Gly Thr Val 
    370                 375                 380                 


Lys Lys Gly Tyr Tyr Gln Met Lys Lys Val Val Lys Thr Val Ala Val 
385                 390                 395                 400 


Lys Ile Leu Lys Asn Glu Ala Asn Asp Pro Ala Leu Lys Asp Glu Leu 
                405                 410                 415     


Leu Ala Glu Ala Asn Val Met Gln Gln Leu Asp Asn Pro Tyr Ile Val 
            420                 425                 430         


Arg Met Ile Gly Ile Cys Glu Ala Glu Ser Trp Met Leu Val Met Glu 
        435                 440                 445             


Met Ala Glu Leu Gly Pro Leu Asn Lys Tyr Leu Gln Gln Asn Arg His 
    450                 455                 460                 


Val Lys Asp Lys Asn Ile Ile Glu Leu Val His Gln Val Ser Met Gly 
465                 470                 475                 480 


Met Lys Tyr Leu Glu Glu Ser Asn Phe Val His Arg Asp Leu Ala Ala 
                485                 490                 495     


Arg Asn Val Leu Leu Val Thr Gln His Tyr Ala Lys Ile Ser Asp Phe 
            500                 505                 510         


Gly Leu Ser Lys Ala Leu Arg Ala Asp Glu Asn Tyr Tyr Lys Ala Gln 
        515                 520                 525             


Thr His Gly Lys Trp Pro Val Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
    530                 535                 540                 


Tyr Tyr Lys Phe Ser Ser Lys Ser Asp Val Trp Ser Phe Gly Val Leu 
545                 550                 555                 560 


Met Trp Glu Ala Phe Ser Tyr Gly Gln Lys Pro Tyr Arg Gly Met Lys 
                565                 570                 575     


Gly Ser Glu Val Thr Ala Met Leu Glu Lys Gly Glu Arg Met Gly Cys 
            580                 585                 590         


Pro Ala Gly Cys Pro Arg Glu Met Tyr Asp Leu Met Asn Leu Cys Trp 
        595                 600                 605             


Thr Tyr Asp Val Glu Asn Arg Pro Gly Phe Ala Ala Val Glu Leu Arg 
    610                 615                 620                 


Leu Arg Asn Tyr Tyr Tyr Asp Val Val Asn 
625                 630                 


<210>  45
<211>  1902
<212>  DNA
<213>  Artifical

<400>  45
gccagcagcg gcatggctga cagcgccaac cacctgccct tctttttcgg caacatcacc     60

cgggaggagg cagaagatta cctggtccag gggggcatga gtgatgggct ttatttgctg    120

cgccagagcc gcaactacct gggtggcttc gccctgtccg tggcccacgg gaggaaggca    180

caccactaca ccatcgagcg ggagctgaat ggcacctacg ccatcgccgg tggcaggacc    240

catgccagcc ccgccgacct ctgccactac cactcccagg agtctgatgg cctggtctgc    300

ctcctcaaga agcccttcaa ccggccccaa ggggtgcagc ccaagactgg gccctttgag    360

gatttgaagg aaaacctcat cagggaatat gtgaagcaga catggaacct gcagggtcag    420

gctctggagc aggccatcat cagtcagaag cctcagctgg agaagctgat cgctaccaca    480

gcccatgaaa aaatgccttg gttccatgga aaaatctctc gggaagaatc tgagcaaatt    540

gtcctgatag gatcaaagac aaatggaaag ttcctgatcc gagccagaga caacaacggc    600

tcctacgccc tgtgcctgct gcacgaaggg aaggtgctgc actatcgcat cgacaaagac    660

aagacaggga agctctccat ccccgaggga aagaagttcg acacgctctg gcagctagtc    720

gagcattatt cttataaagc agatggtttg ttaagagttc ttactgtccc atgtcaaaaa    780

atcggcacac agggaaatgt taattttgga ggccgtccac aacttccagg ttcccatcct    840

gcgacttggt cagcgggtgg aataatctca agaatcaaat catactcctt cccaaagcct    900

ggccacagaa agtcctcccc tgcccaaggg aaccggcaag agagtactgt gtcattcaat    960

ccgtatgagc cagaacttgc accctgggct gcagacaaag gcccccagag agaagcccta   1020

cccatggaca cagaggtgta cgagagcccc tacgcggacc ccgaggagat caggcccaag   1080

gaggtttacc tggaccgaaa gctgctgacg ctggaagaca aagaactggg ctctggtaat   1140

tttggaactg tgaaaaaggg ctactaccaa atgaaaaaag ttgtgaaaac cgtggctgtg   1200

aaaatactga aaaacgaggc caatgacccc gctcttaaag atgagttatt agcagaagca   1260

aatgtcatgc agcagctgga caacccgtac atcgtgcgga tgatcgggat atgcgaggcc   1320

gagtcctgga tgctggttat ggagatggca gaacttggtc ccctcaataa gtatttgcag   1380

cagaacagac atgtcaagga taagaacatc atagaactgg ttcatcaggt ttccatgggc   1440

atgaagtact tggaggagag caattttgtg cacagagatc tggctgcaag aaatgtgttg   1500

ctagttaccc aacattacgc caagatcagt gatttcggac tttccaaagc actgcgtgct   1560

gatgaaaact actacaaggc ccagacccat ggaaagtggc ctgtcaagtg gtacgctccg   1620

gaatgcatca actactacaa gttctccagc aaaagcgatg tctggagctt tggagtgttg   1680

atgtgggaag cattctccta tgggcagaag ccatatcgag ggatgaaagg aagtgaagtc   1740

accgctatgt tagagaaagg agagcggatg gggtgccctg cagggtgtcc aagagagatg   1800

tacgatctca tgaatctgtg ctggacatac gatgtggaaa acaggcccgg attcgcagca   1860

gtggaactgc ggctgcgcaa ttactactat gacgtggtga ac                      1902


<210>  46
<211>  336
<212>  PRT
<213>  Artifical

<400>  46

Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser Arg 
1               5                   10                  15      


Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly Leu 
            20                  25                  30          


Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu Ser 
        35                  40                  45              


Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln Leu 
    50                  55                  60                  


Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro Ala 
65                  70                  75                  80  


Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys Asn 
                85                  90                  95      


Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro Gly 
            100                 105                 110         


Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg Gln 
        115                 120                 125             


Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser Gln 
    130                 135                 140                 


Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg Met 
145                 150                 155                 160 


Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys Leu 
                165                 170                 175     


Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg Lys 
            180                 185                 190         


Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val Tyr 
        195                 200                 205             


His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro Glu 
    210                 215                 220                 


Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys Leu 
225                 230                 235                 240 


Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn Ser 
                245                 250                 255     


Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala His 
            260                 265                 270         


Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn Ser 
        275                 280                 285             


Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys Pro 
    290                 295                 300                 


Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser Asp 
305                 310                 315                 320 


Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn Leu 
                325                 330                 335     


<210>  47
<211>  1008
<212>  DNA
<213>  Artifical

<400>  47
ccagaccccg cggcgcacct gcccttcttc tacggcagca tctcgcgtgc cgaggccgag     60

gagcacctga agctggcggg catggcggac gggctcttcc tgctgcgcca gtgcctgcgc    120

tcgctgggcg gctatgtgct gtcgctcgtg cacgatgtgc gcttccacca ctttcccatc    180

gagcgccagc tcaacggcac ctacgccatt gccggcggca aagcgcactg tggaccggca    240

gagctctgcg agttctactc gcgcgacccc gacgggctgc cctgcaacct gcgcaagccg    300

tgcaaccggc cgtcgggcct cgagccgcag ccgggggtct tcgactgcct gcgagacgcc    360

atggtgcgtg actacgtgcg ccagacgtgg aagctggagg gcgaggccct ggagcaggcc    420

atcatcagcc aggccccgca ggtggagaag ctcattgcta cgacggccca cgagcggatg    480

ccctggtacc acagcagcct gacgcgtgag gaggccgagc gcaaacttta ctctggggcg    540

cagaccgacg gcaagttcct gctgaggccg cggaaggagc agggcacata cgccctgtcc    600

ctcatctatg ggaagacggt gtaccactac ctcatcagcc aagacaaggc gggcaagtac    660

tgcattcccg agggcaccaa gtttgacacg ctctggcagc tggtggagta tctgaagctg    720

aaggcggacg ggctcatcta ctgcctgaag gaggcctgcc ccaacagcag tgccagcaac    780

gcctcagggg ctgctgctcc cacactccca gcccacccat ccacgttgac tcatcctcag    840

agacgaatcg acaccctcaa ctcagatgga tacacccctg agccagcacg cataacgtcc    900

ccagacaaac cgcggccgat gcccatggac acgagcgtgt atgagagccc ctacagcgac    960

ccagaggagc tcaaggacaa gaagctcttc ctgaagcgcg ataacctc                1008


<210>  48
<211>  369
<212>  PRT
<213>  Artifical

<400>  48

Ala Ser Ser Gly Met Ala Asp Ser Ala Asn His Leu Pro Phe Phe Phe 
1               5                   10                  15      


Gly Asn Ile Thr Arg Glu Glu Ala Glu Asp Tyr Leu Val Gln Gly Gly 
            20                  25                  30          


Met Ser Asp Gly Leu Tyr Leu Leu Arg Gln Ser Arg Asn Tyr Leu Gly 
        35                  40                  45              


Gly Phe Ala Leu Ser Val Ala His Gly Arg Lys Ala His His Tyr Thr 
    50                  55                  60                  


Ile Glu Arg Glu Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Arg Thr 
65                  70                  75                  80  


His Ala Ser Pro Ala Asp Leu Cys His Tyr His Ser Gln Glu Ser Asp 
                85                  90                  95      


Gly Leu Val Cys Leu Leu Lys Lys Pro Phe Asn Arg Pro Gln Gly Val 
            100                 105                 110         


Gln Pro Lys Thr Gly Pro Phe Glu Asp Leu Lys Glu Asn Leu Ile Arg 
        115                 120                 125             


Glu Tyr Val Lys Gln Thr Trp Asn Leu Gln Gly Gln Ala Leu Glu Gln 
    130                 135                 140                 


Ala Ile Ile Ser Gln Lys Pro Gln Leu Glu Lys Leu Ile Ala Thr Thr 
145                 150                 155                 160 


Ala His Glu Lys Met Pro Trp Phe His Gly Lys Ile Ser Arg Glu Glu 
                165                 170                 175     


Ser Glu Gln Ile Val Leu Ile Gly Ser Lys Thr Asn Gly Lys Phe Leu 
            180                 185                 190         


Ile Arg Ala Arg Asp Asn Asn Gly Ser Tyr Ala Leu Cys Leu Leu His 
        195                 200                 205             


Glu Gly Lys Val Leu His Tyr Arg Ile Asp Lys Asp Lys Thr Gly Lys 
    210                 215                 220                 


Leu Ser Ile Pro Glu Gly Lys Lys Phe Asp Thr Leu Trp Gln Leu Val 
225                 230                 235                 240 


Glu His Tyr Ser Tyr Lys Ala Asp Gly Leu Leu Arg Val Leu Thr Val 
                245                 250                 255     


Pro Cys Gln Lys Ile Gly Thr Gln Gly Asn Val Asn Phe Gly Gly Arg 
            260                 265                 270         


Pro Gln Leu Pro Gly Ser His Pro Ala Thr Trp Ser Ala Gly Gly Ile 
        275                 280                 285             


Ile Ser Arg Ile Lys Ser Tyr Ser Phe Pro Lys Pro Gly His Arg Lys 
    290                 295                 300                 


Ser Ser Pro Ala Gln Gly Asn Arg Gln Glu Ser Thr Val Ser Phe Asn 
305                 310                 315                 320 


Pro Tyr Glu Pro Glu Leu Ala Pro Trp Ala Ala Asp Lys Gly Pro Gln 
                325                 330                 335     


Arg Glu Ala Leu Pro Met Asp Thr Glu Val Tyr Glu Ser Pro Tyr Ala 
            340                 345                 350         


Asp Pro Glu Glu Ile Arg Pro Lys Glu Val Tyr Leu Asp Arg Lys Leu 
        355                 360                 365             


Leu 
    


<210>  49
<211>  1107
<212>  DNA
<213>  Artifical

<400>  49
gccagcagcg gcatggctga cagcgccaac cacctgccct tctttttcgg caacatcacc     60

cgggaggagg cagaagatta cctggtccag gggggcatga gtgatgggct ttatttgctg    120

cgccagagcc gcaactacct gggtggcttc gccctgtccg tggcccacgg gaggaaggca    180

caccactaca ccatcgagcg ggagctgaat ggcacctacg ccatcgccgg tggcaggacc    240

catgccagcc ccgccgacct ctgccactac cactcccagg agtctgatgg cctggtctgc    300

ctcctcaaga agcccttcaa ccggccccaa ggggtgcagc ccaagactgg gccctttgag    360

gatttgaagg aaaacctcat cagggaatat gtgaagcaga catggaacct gcagggtcag    420

gctctggagc aggccatcat cagtcagaag cctcagctgg agaagctgat cgctaccaca    480

gcccatgaaa aaatgccttg gttccatgga aaaatctctc gggaagaatc tgagcaaatt    540

gtcctgatag gatcaaagac aaatggaaag ttcctgatcc gagccagaga caacaacggc    600

tcctacgccc tgtgcctgct gcacgaaggg aaggtgctgc actatcgcat cgacaaagac    660

aagacaggga agctctccat ccccgaggga aagaagttcg acacgctctg gcagctagtc    720

gagcattatt cttataaagc agatggtttg ttaagagttc ttactgtccc atgtcaaaaa    780

atcggcacac agggaaatgt taattttgga ggccgtccac aacttccagg ttcccatcct    840

gcgacttggt cagcgggtgg aataatctca agaatcaaat catactcctt cccaaagcct    900

ggccacagaa agtcctcccc tgcccaaggg aaccggcaag agagtactgt gtcattcaat    960

ccgtatgagc cagaacttgc accctgggct gcagacaaag gcccccagag agaagcccta   1020

cccatggaca cagaggtgta cgagagcccc tacgcggacc ccgaggagat caggcccaag   1080

gaggtttacc tggaccgaaa gctgctg                                       1107


<210>  50
<211>  263
<212>  PRT
<213>  Artifical

<400>  50

Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val Arg 
1               5                   10                  15      


Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile Lys 
            20                  25                  30          


Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met Arg 
        35                  40                  45              


Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg Leu 
    50                  55                  60                  


Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met Ala 
65                  70                  75                  80  


Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu Ile 
                85                  90                  95      


Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly Met 
            100                 105                 110         


Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala Arg 
        115                 120                 125             


Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe Gly 
    130                 135                 140                 


Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg Ser 
145                 150                 155                 160 


Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn Phe 
                165                 170                 175     


Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr Met 
            180                 185                 190         


Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys Gly 
        195                 200                 205             


Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys Pro 
    210                 215                 220                 


Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp Ile 
225                 230                 235                 240 


Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg Met 
                245                 250                 255     


Arg Ala Cys Tyr Tyr Ser Leu 
            260             


<210>  51
<211>  789
<212>  DNA
<213>  Artifical

<400>  51
ctcatagctg acattgaact tggctgcggc aactttggct cagtgcgcca gggcgtgtac     60

cgcatgcgca agaagcagat cgacgtggcc atcaaggtgc tgaagcaggg cacggagaag    120

gcagacacgg aagagatgat gcgcgaggcg cagatcatgc accagctgga caacccctac    180

atcgtgcggc tcattggcgt ctgccaggcc gaggccctca tgctggtcat ggagatggct    240

gggggcgggc cgctgcacaa gttcctggtc ggcaagaggg aggagatccc tgtgagcaat    300

gtggccgagc tgctgcacca ggtgtccatg gggatgaagt acctggagga gaagaacttt    360

gtgcaccgtg acctggcggc ccgcaacgtc ctgctggtta accggcacta cgccaagatc    420

agcgactttg gcctctccaa agcactgggt gccgacgaca gctactacac tgcccgctca    480

gcagggaagt ggccgctcaa gtggtacgca cccgaatgca tcaacttccg caagttctcc    540

agccgcagcg atgtctggag ctatggggtc accatgtggg aggccttgtc ctacggccag    600

aagccctaca agaagatgaa agggccggag gtcatggcct tcatcgagca gggcaagcgg    660

atggagtgcc caccagagtg tccacccgaa ctgtacgcac tcatgagtga ctgctggatc    720

tacaagtggg aggatcgccc cgacttcctg accgtggagc agcgcatgcg agcctgttac    780

tacagcctg                                                            789


<210>  52
<211>  261
<212>  PRT
<213>  Artifical

<400>  52

Thr Leu Glu Asp Lys Glu Leu Gly Ser Gly Asn Phe Gly Thr Val Lys 
1               5                   10                  15      


Lys Gly Tyr Tyr Gln Met Lys Lys Val Val Lys Thr Val Ala Val Lys 
            20                  25                  30          


Ile Leu Lys Asn Glu Ala Asn Asp Pro Ala Leu Lys Asp Glu Leu Leu 
        35                  40                  45              


Ala Glu Ala Asn Val Met Gln Gln Leu Asp Asn Pro Tyr Ile Val Arg 
    50                  55                  60                  


Met Ile Gly Ile Cys Glu Ala Glu Ser Trp Met Leu Val Met Glu Met 
65                  70                  75                  80  


Ala Glu Leu Gly Pro Leu Asn Lys Tyr Leu Gln Gln Asn Arg His Val 
                85                  90                  95      


Lys Asp Lys Asn Ile Ile Glu Leu Val His Gln Val Ser Met Gly Met 
            100                 105                 110         


Lys Tyr Leu Glu Glu Ser Asn Phe Val His Arg Asp Leu Ala Ala Arg 
        115                 120                 125             


Asn Val Leu Leu Val Thr Gln His Tyr Ala Lys Ile Ser Asp Phe Gly 
    130                 135                 140                 


Leu Ser Lys Ala Leu Arg Ala Asp Glu Asn Tyr Tyr Lys Ala Gln Thr 
145                 150                 155                 160 


His Gly Lys Trp Pro Val Lys Trp Tyr Ala Pro Glu Cys Ile Asn Tyr 
                165                 170                 175     


Tyr Lys Phe Ser Ser Lys Ser Asp Val Trp Ser Phe Gly Val Leu Met 
            180                 185                 190         


Trp Glu Ala Phe Ser Tyr Gly Gln Lys Pro Tyr Arg Gly Met Lys Gly 
        195                 200                 205             


Ser Glu Val Thr Ala Met Leu Glu Lys Gly Glu Arg Met Gly Cys Pro 
    210                 215                 220                 


Ala Gly Cys Pro Arg Glu Met Tyr Asp Leu Met Asn Leu Cys Trp Thr 
225                 230                 235                 240 


Tyr Asp Val Glu Asn Arg Pro Gly Phe Ala Ala Val Glu Leu Arg Leu 
                245                 250                 255     


Arg Asn Tyr Tyr Tyr 
            260     


<210>  53
<211>  783
<212>  DNA
<213>  Artifical

<400>  53
acgctggaag acaaagaact gggctctggt aattttggaa ctgtgaaaaa gggctactac     60

caaatgaaaa aagttgtgaa aaccgtggct gtgaaaatac tgaaaaacga ggccaatgac    120

cccgctctta aagatgagtt attagcagaa gcaaatgtca tgcagcagct ggacaacccg    180

tacatcgtgc ggatgatcgg gatatgcgag gccgagtcct ggatgctggt tatggagatg    240

gcagaacttg gtcccctcaa taagtatttg cagcagaaca gacatgtcaa ggataagaac    300

atcatagaac tggttcatca ggtttccatg ggcatgaagt acttggagga gagcaatttt    360

gtgcacagag atctggctgc aagaaatgtg ttgctagtta cccaacatta cgccaagatc    420

agtgatttcg gactttccaa agcactgcgt gctgatgaaa actactacaa ggcccagacc    480

catggaaagt ggcctgtcaa gtggtacgct ccggaatgca tcaactacta caagttctcc    540

agcaaaagcg atgtctggag ctttggagtg ttgatgtggg aagcattctc ctatgggcag    600

aagccatatc gagggatgaa aggaagtgaa gtcaccgcta tgttagagaa aggagagcgg    660

atggggtgcc ctgcagggtg tccaagagag atgtacgatc tcatgaatct gtgctggaca    720

tacgatgtgg aaaacaggcc cggattcgca gcagtggaac tgcggctgcg caattactac    780

tat                                                                  783


<210>  54
<211>  29
<212>  PRT
<213>  Artifical

<400>  54

Cys Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln 
1               5                   10                  15      


Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser 
            20                  25                  


<210>  55
<211>  87
<212>  DNA
<213>  Artifical

<400>  55
tgctcccggg ccgcacgagg gacaatagga gccaggcgca ccggccagcc cctgaaggag     60

gacccctcag ccgtgcctgt gttctct                                         87


<210>  56
<211>  97
<212>  PRT
<213>  Artifical

<400>  56

Cys Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln 
1               5                   10                  15      


Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr 
            20                  25                  30          


Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val 
        35                  40                  45              


Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser 
    50                  55                  60                  


Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro 
65                  70                  75                  80  


Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro 
                85                  90                  95      


Leu 
    


<210>  57
<211>  291
<212>  DNA
<213>  Artifical

<400>  57
tgctcccggg ccgcacgagg gacaatagga gccaggcgca ccggccagcc cctgaaggag     60

gacccctcag ccgtgcctgt gttctctgtg gactatgggg agctggattt ccagtggcga    120

gagaagaccc cggagccccc cgtgccctgt gtccctgagc agacggagta tgccaccatt    180

gtctttccta gcggaatggg cacctcatcc cccgcccgca ggggctcagc tgacggccct    240

cggagtgccc agccactgag gcctgaggat ggacactgct cttggcccct c             291


<210>  58
<211>  12
<212>  PRT
<213>  Artifical

<400>  58

Gly Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Thr 
1               5                   10          


<210>  59
<211>  36
<212>  DNA
<213>  Artifical

<400>  59
ggcgggtctg gcgggacagg aggttcaggt ggcaca                               36


<210>  60
<211>  34
<212>  PRT
<213>  Artifical

<400>  60

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
            20                  25                  30          


Thr Lys 
        


<210>  61
<211>  102
<212>  DNA
<213>  Artifical

<400>  61
ggttcaactt ctggctctgg gaaaccagga agcggcgaag ggtccaccaa gggaagcacc     60

agtggttcag gtaagcctgg ttctggtgaa ggtagcacta aa                       102


<210>  62
<211>  128
<212>  PRT
<213>  Artifical

<400>  62

Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly 
1               5                   10                  15      


Ser Ala Gly Gly Ser Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Thr 
            20                  25                  30          


Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly 
        35                  40                  45              


Ser Ala Gly Gly Ser Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Thr 
    50                  55                  60                  


Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly 
65                  70                  75                  80  


Ser Ala Gly Gly Ser Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Thr 
                85                  90                  95      


Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly 
            100                 105                 110         


Ser Ala Gly Gly Gly Gly Ser Gly Gly Thr Gly Gly Ser Gly Gly Thr 
        115                 120                 125             


<210>  63
<211>  384
<212>  DNA
<213>  Artifical

<400>  63
agcgcaggcg gatcagctgg agggtctgca gggggtagtg caggtggctc agctggcggg     60

agcggctcag ctgggggatc tgctggtggc agtacctcag caggcggtag cgccggaggt    120

tctgctggtg gctccgcagg agggtctgca ggcggttccg ggagtgcagg tggatctgca    180

ggtgggtcaa caagtgctgg tggatccgca ggaggttcag caggcgggag tgctggaggc    240

tctgcaggcg gtagcgggag tgccggtggc agcgcagggg gaagcactag tgctggaggc    300

agtgcaggtg gcagcgcagg aggctctgcc gggggaagcg ccgggggcgg cgggtctggc    360

gggacaggag gttcaggtgg caca                                           384


<210>  64
<211>  116
<212>  PRT
<213>  Artifical

<400>  64

Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly 
1               5                   10                  15      


Ser Ala Gly Gly Ser Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Thr 
            20                  25                  30          


Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly 
        35                  40                  45              


Ser Ala Gly Gly Ser Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Thr 
    50                  55                  60                  


Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly 
65                  70                  75                  80  


Ser Ala Gly Gly Ser Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Thr 
                85                  90                  95      


Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly Ser Ala Gly Gly 
            100                 105                 110         


Ser Ala Gly Gly 
        115     


<210>  65
<211>  348
<212>  DNA
<213>  Artifical

<400>  65
agcgcaggcg gatcagctgg agggtctgca gggggtagtg caggtggctc agctggcggg     60

agcggctcag ctgggggatc tgctggtggc agtacctcag caggcggtag cgccggaggt    120

tctgctggtg gctccgcagg agggtctgca ggcggttccg ggagtgcagg tggatctgca    180

ggtgggtcaa caagtgctgg tggatccgca ggaggttcag caggcgggag tgctggaggc    240

tctgcaggcg gtagcgggag tgccggtggc agcgcagggg gaagcactag tgctggaggc    300

agtgcaggtg gcagcgcagg aggctctgcc gggggaagcg ccgggggc                 348


<210>  66
<211>  6
<212>  PRT
<213>  Artifical

<400>  66

Gly Gly Ser Gly Gly Thr 
1               5       


