﻿               序列表

<110> 神州细胞工程有限公司

<120> 嵌合的人乳头瘤病毒11型L1蛋白

<130> CIE200049PCT

<160> 14

<170> BiSSAP 1.3.6

<210> 1
<211> 470
<212> PRT
<213> 智人


<220> 
<223> HPV 11型L1蛋白的1-470氨基酸序列

<400> 1
Met Trp Arg Pro Ser Asp Ser Thr Val Tyr Val Pro Pro Pro Asn Pro 
1               5                   10                  15      
Val Ser Lys Val Val Ala Thr Asp Ala Tyr Val Lys Arg Thr Asn Ile 
            20                  25                  30          
Phe Tyr His Ala Ser Ser Ser Arg Leu Leu Ala Val Gly His Pro Tyr 
        35                  40                  45              
Tyr Ser Ile Lys Lys Val Asn Lys Thr Val Val Pro Lys Val Ser Gly 
    50                  55                  60                  
Tyr Gln Tyr Arg Val Phe Lys Val Val Leu Pro Asp Pro Asn Lys Phe 
65                  70                  75                  80  
Ala Leu Pro Asp Ser Ser Leu Phe Asp Pro Thr Thr Gln Arg Leu Val 
                85                  90                  95      
Trp Ala Cys Thr Gly Leu Glu Val Gly Arg Gly Gln Pro Leu Gly Val 
            100                 105                 110         
Gly Val Ser Gly His Pro Leu Leu Asn Lys Tyr Asp Asp Val Glu Asn 
        115                 120                 125             
Ser Gly Gly Tyr Gly Gly Asn Pro Gly Gln Asp Asn Arg Val Asn Val 
    130                 135                 140                 
Gly Met Asp Tyr Lys Gln Thr Gln Leu Cys Met Val Gly Cys Ala Pro 
145                 150                 155                 160 
Pro Leu Gly Glu His Trp Gly Lys Gly Thr Gln Cys Ser Asn Thr Ser 
                165                 170                 175     
Val Gln Asn Gly Asp Cys Pro Pro Leu Glu Leu Ile Thr Ser Val Ile 
            180                 185                 190         
Gln Asp Gly Asp Met Val Asp Thr Gly Phe Gly Ala Met Asn Phe Ala 
        195                 200                 205             
Asp Leu Gln Thr Asn Lys Ser Asp Val Pro Leu Asp Ile Cys Gly Thr 
    210                 215                 220                 
Val Cys Lys Tyr Pro Asp Tyr Leu Gln Met Ala Ala Asp Pro Tyr Gly 
225                 230                 235                 240 
Asp Arg Leu Phe Phe Tyr Leu Arg Lys Glu Gln Met Phe Ala Arg His 
                245                 250                 255     
Phe Phe Asn Arg Ala Gly Thr Val Gly Glu Pro Val Pro Asp Asp Leu 
            260                 265                 270         
Leu Val Lys Gly Gly Asn Asn Arg Ser Ser Val Ala Ser Ser Ile Tyr 
        275                 280                 285             
Val His Thr Pro Ser Gly Ser Leu Val Ser Ser Glu Ala Gln Leu Phe 
    290                 295                 300                 
Asn Lys Pro Tyr Trp Leu Gln Lys Ala Gln Gly His Asn Asn Gly Ile 
305                 310                 315                 320 
Cys Trp Gly Asn His Leu Phe Val Thr Val Val Asp Thr Thr Arg Ser 
                325                 330                 335     
Thr Asn Met Thr Leu Cys Ala Ser Val Ser Lys Ser Ala Thr Tyr Thr 
            340                 345                 350         
Asn Ser Asp Tyr Lys Glu Tyr Met Arg His Val Glu Glu Phe Asp Leu 
        355                 360                 365             
Gln Phe Ile Phe Gln Leu Cys Ser Ile Thr Leu Ser Ala Glu Val Met 
    370                 375                 380                 
Ala Tyr Ile His Thr Met Asn Pro Ser Val Leu Glu Asp Trp Asn Phe 
385                 390                 395                 400 
Gly Leu Ser Pro Pro Pro Asn Gly Thr Leu Glu Asp Thr Tyr Arg Tyr 
                405                 410                 415     
Val Gln Ser Gln Ala Ile Thr Cys Gln Lys Pro Thr Pro Glu Lys Glu 
            420                 425                 430         
Lys Gln Asp Pro Tyr Lys Asp Met Ser Phe Trp Glu Val Asn Leu Lys 
        435                 440                 445             
Glu Lys Phe Ser Ser Glu Leu Asp Gln Phe Pro Leu Gly Arg Lys Phe 
    450                 455                 460                 
Leu Leu Gln Ser Gly Tyr 
465                 470 

<210> 2
<211> 26
<212> PRT
<213> 智人


<220> 
<223> HPV 33型L1蛋白的474-499氨基酸序列

<400> 2
Lys Ala Lys Pro Lys Leu Lys Arg Ala Ala Pro Thr Ser Thr Arg Thr 
1               5                   10                  15      
Ser Ser Ala Lys Arg Lys Lys Val Lys Lys 
            20                  25      

<210> 3
<211> 496
<212> PRT
<213> 人工序列


<220> 
<223> 嵌合的HPV 11型L1蛋白的氨基酸序列

<400> 3
Met Trp Arg Pro Ser Asp Ser Thr Val Tyr Val Pro Pro Pro Asn Pro 
1               5                   10                  15      
Val Ser Lys Val Val Ala Thr Asp Ala Tyr Val Lys Arg Thr Asn Ile 
            20                  25                  30          
Phe Tyr His Ala Ser Ser Ser Arg Leu Leu Ala Val Gly His Pro Tyr 
        35                  40                  45              
Tyr Ser Ile Lys Lys Val Asn Lys Thr Val Val Pro Lys Val Ser Gly 
    50                  55                  60                  
Tyr Gln Tyr Arg Val Phe Lys Val Val Leu Pro Asp Pro Asn Lys Phe 
65                  70                  75                  80  
Ala Leu Pro Asp Ser Ser Leu Phe Asp Pro Thr Thr Gln Arg Leu Val 
                85                  90                  95      
Trp Ala Cys Thr Gly Leu Glu Val Gly Arg Gly Gln Pro Leu Gly Val 
            100                 105                 110         
Gly Val Ser Gly His Pro Leu Leu Asn Lys Tyr Asp Asp Val Glu Asn 
        115                 120                 125             
Ser Gly Gly Tyr Gly Gly Asn Pro Gly Gln Asp Asn Arg Val Asn Val 
    130                 135                 140                 
Gly Met Asp Tyr Lys Gln Thr Gln Leu Cys Met Val Gly Cys Ala Pro 
145                 150                 155                 160 
Pro Leu Gly Glu His Trp Gly Lys Gly Thr Gln Cys Ser Asn Thr Ser 
                165                 170                 175     
Val Gln Asn Gly Asp Cys Pro Pro Leu Glu Leu Ile Thr Ser Val Ile 
            180                 185                 190         
Gln Asp Gly Asp Met Val Asp Thr Gly Phe Gly Ala Met Asn Phe Ala 
        195                 200                 205             
Asp Leu Gln Thr Asn Lys Ser Asp Val Pro Leu Asp Ile Cys Gly Thr 
    210                 215                 220                 
Val Cys Lys Tyr Pro Asp Tyr Leu Gln Met Ala Ala Asp Pro Tyr Gly 
225                 230                 235                 240 
Asp Arg Leu Phe Phe Tyr Leu Arg Lys Glu Gln Met Phe Ala Arg His 
                245                 250                 255     
Phe Phe Asn Arg Ala Gly Thr Val Gly Glu Pro Val Pro Asp Asp Leu 
            260                 265                 270         
Leu Val Lys Gly Gly Asn Asn Arg Ser Ser Val Ala Ser Ser Ile Tyr 
        275                 280                 285             
Val His Thr Pro Ser Gly Ser Leu Val Ser Ser Glu Ala Gln Leu Phe 
    290                 295                 300                 
Asn Lys Pro Tyr Trp Leu Gln Lys Ala Gln Gly His Asn Asn Gly Ile 
305                 310                 315                 320 
Cys Trp Gly Asn His Leu Phe Val Thr Val Val Asp Thr Thr Arg Ser 
                325                 330                 335     
Thr Asn Met Thr Leu Cys Ala Ser Val Ser Lys Ser Ala Thr Tyr Thr 
            340                 345                 350         
Asn Ser Asp Tyr Lys Glu Tyr Met Arg His Val Glu Glu Phe Asp Leu 
        355                 360                 365             
Gln Phe Ile Phe Gln Leu Cys Ser Ile Thr Leu Ser Ala Glu Val Met 
    370                 375                 380                 
Ala Tyr Ile His Thr Met Asn Pro Ser Val Leu Glu Asp Trp Asn Phe 
385                 390                 395                 400 
Gly Leu Ser Pro Pro Pro Asn Gly Thr Leu Glu Asp Thr Tyr Arg Tyr 
                405                 410                 415     
Val Gln Ser Gln Ala Ile Thr Cys Gln Lys Pro Thr Pro Glu Lys Glu 
            420                 425                 430         
Lys Gln Asp Pro Tyr Lys Asp Met Ser Phe Trp Glu Val Asn Leu Lys 
        435                 440                 445             
Glu Lys Phe Ser Ser Glu Leu Asp Gln Phe Pro Leu Gly Arg Lys Phe 
    450                 455                 460                 
Leu Leu Gln Ser Gly Tyr Lys Ala Lys Pro Lys Leu Lys Arg Ala Ala 
465                 470                 475                 480 
Pro Thr Ser Thr Arg Thr Ser Ser Ala Lys Arg Lys Lys Val Lys Lys 
                485                 490                 495     



<210> 4
<211> 1492
<212> DNA
<213> 人工序列


<220> 
<223> 嵌合的HPV 11型L1蛋白的核苷酸序列

<400> 4
atgtggagac catctgacag cacagtctat gtgcctcctc caaaccctgt gagcaaggtg      60

gtggctacag atgcctatgt gaagaggacc aacatcttct accatgcctc ctccagcaga     120

ctgctggctg tgggacaccc atactacagc atcaagaagg tgaacaagac agtggtgcca     180

aaggtgtctg gctaccaata cagggtgttc aaggtggtgc tgcctgaccc aaacaagttt     240

gccctgcctg actcctccct gtttgaccca accacccaga gactggtgtg ggcttgtact     300

ggattggagg tgggcagggg acaaccactg ggagtgggag tgtctggaca cccactgctg     360

aacaaatatg atgatgtgga gaactctgga ggctatggag gcaaccctgg acaagacaac     420

agggtgaatg tggggatgga ctacaagcag acccaacttt gtatggtggg ctgtgcccct     480

ccactgggag aacactgggg caagggcacc cagtgtagca acacctctgt ccagaatgga     540

gactgtcctc cattggaact gattacctct gtgattcagg atggagatat ggtggacaca     600

ggctttggag ctatgaactt tgctgacctc caaaccaaca agtctgatgt gccactggac     660

atctgtggca cagtgtgtaa ataccctgac tacctccaaa tggctgctga cccatatgga     720

gacagactgt tcttctacct gaggaaggaa cagatgtttg ccagacactt cttcaacagg     780

gctggcacag tgggagaacc tgtgcctgat gacctgctgg tgaagggagg caacaacagg     840

tcctctgtgg catccagcat ctatgtgcat acaccatctg gctccctggt gtcctctgag     900

gctcaacttt tcaacaagcc atactggctc caaaaggctc aaggacacaa caatggcatc     960

tgttggggca accacctgtt tgtgacagtg gtggacacca ccaggagcac caatatgacc    1020

ctgtgtgcct ctgtgagcaa gtctgccacc tacaccaact ctgactacaa ggaatatatg    1080

aggcatgtgg aggagtttga cctccaattc atcttccaac tttgtagcat caccctgtct    1140

gctgaggtga tggcttacat ccacacaatg aacccatctg tgttggagga ctggaacttt    1200

ggactgagcc ctcctccaaa tggcaccttg gaggacacct acagatatgt ccagagccag    1260

gctatcactt gtcagaagcc aacacctgag aaggagaagc aggacccata caaggatatg    1320

agtttctggg aggtgaacct gaaagagaag ttctcctctg aactggacca gtttccactg    1380

ggcaggaagt tcctgctcca atctggctac aaagccaagc caaaactgaa aagggctgcc    1440

ccaaccagca ccaggacctc ctctgccaag aggaagaagg tgaagaagta aa            1492


<210> 5
<211> 1525
<212> DNA
<213> 人工序列


<220> 
<223> 合成的HPV11L1基因

<400> 5
ctgggtacca tgtggagacc atctgacagc acagtctatg tgcctcctcc aaaccctgtg      60

agcaaggtgg tggctacaga tgcctatgtg aagaggacca acatcttcta ccatgcctcc     120

tccagcagac tgctggctgt gggacaccca tactacagca tcaagaaggt gaacaagaca     180

gtggtgccaa aggtgtctgg ctaccaatac agggtgttca aggtggtgct gcctgaccca     240

aacaagtttg ccctgcctga ctcctccctg tttgacccaa ccacccagag actggtgtgg     300

gcttgtactg gattggaggt gggcagggga caaccactgg gagtgggagt gtctggacac     360

ccactgctga acaaatatga tgatgtggag aactctggag gctatggagg caaccctgga     420

caagacaaca gggtgaatgt ggggatggac tacaagcaga cccaactttg tatggtgggc     480

tgtgcccctc cactgggaga acactggggc aagggcaccc agtgtagcaa cacctctgtc     540

cagaatggag actgtcctcc attggaactg attacctctg tgattcagga tggagatatg     600

gtggacacag gctttggagc tatgaacttt gctgacctcc aaaccaacaa gtctgatgtg     660

ccactggaca tctgtggcac agtgtgtaaa taccctgact acctccaaat ggctgctgac     720

ccatatggag acagactgtt cttctacctg aggaaggaac agatgtttgc cagacacttc     780

ttcaacaggg ctggcacagt gggagaacct gtgcctgatg acctgctggt gaagggaggc     840

aacaacaggt cctctgtggc atccagcatc tatgtgcata caccatctgg ctccctggtg     900

tcctctgagg ctcaactttt caacaagcca tactggctcc aaaaggctca aggacacaac     960

aatggcatct gttggggcaa ccacctgttt gtgacagtgg tggacaccac caggagcacc    1020

aatatgaccc tgtgtgcctc tgtgagcaag tctgccacct acaccaactc tgactacaag    1080

gaatatatga ggcatgtgga ggagtttgac ctccaattca tcttccaact ttgtagcatc    1140

accctgtctg ctgaggtgat ggcttacatc cacacaatga acccatctgt gttggaggac    1200

tggaactttg gactgagccc tcctccaaat ggcaccttgg aggacaccta cagatatgtc    1260

cagagccagg ctatcacttg tcagaagcca acacctgaga aggagaagca ggacccatac    1320

aaggatatga gtttctggga ggtgaacctg aaagagaagt tctcctctga actggaccag    1380

tttccactgg gcaggaagtt cctgctccaa tctggctaca ggggcaggac ctctgccagg    1440

acaggcatca agagacctgc tgtgagcaag ccaagcacag ccccaaagag gaagaggacc    1500

aagaccaaga agtaaactcg agctc                                          1525


<210> 6
<211> 1519
<212> DNA
<213> 人工序列


<220> 
<223> 合成的HPV33L1基因

<400> 6
ctgggtacca tgagtgtgtg gagaccatct gaggctacag tctacctgcc tcctgtgcct      60

gtgagcaagg tggtgagcac agatgaatat gtgagcagga ccagcatcta ctactatgct     120

ggctccagca gactgctggc tgtgggacac ccatacttca gcatcaagaa cccaaccaat     180

gccaagaaac tgctggtgcc aaaggtgtct ggactccaat acagggtgtt cagggtgaga     240

ctgcctgacc caaacaagtt tggctttcct gacacctcct tctacaaccc tgacacccag     300

agactggtgt gggcttgtgt gggattggag attggcaggg gacaaccact gggagtgggc     360

atctctggac acccactgct gaacaagttt gatgacacag agacaggcaa caaataccct     420

ggacaacctg gagcagacaa cagggagtgt ctgagtatgg actacaagca gacccaactt     480

tgtctgctgg gctgtaagcc tccaacagga gaacactggg gcaagggagt ggcttgtacc     540

aatgctgccc ctgccaatga ctgtcctcca ttggaactga taaacaccat cattgaggat     600

ggagatatgg tggacacagg ctttggctgt atggacttca agaccctcca agccaacaag     660

tctgatgtgc caattgacat ctgtggcagc acttgtaaat accctgacta cctgaaaatg     720

acctctgaac catatggaga ctccctgttc ttcttcctga ggagggaaca gatgtttgtg     780

agacacttct tcaacagggc tggcaccctg ggagaggctg tgcctgatga cctctacatc     840

aagggctctg gcaccacagc cagcatccag tcctctgcct tctttccaac accatctggc     900

agtatggtga cctctgagag ccaacttttc aacaagccat actggctcca aagggctcaa     960

ggacacaaca atggcatctg ttggggcaac caggtgtttg tgacagtggt ggacaccacc    1020

aggagcacca atatgaccct gtgtacccag gtgacctctg acagcaccta caagaatgag    1080

aacttcaagg aatacatcag gcatgtggag gaatatgacc tccaatttgt gttccaactt    1140

tgtaaggtga ccctgacagc agaggtgatg acctacatcc atgctatgaa ccctgacatc    1200

ttggaggact ggcagtttgg actgacacct cctccatctg cctccctcca agacacctac    1260

aggtttgtga ccagccaggc tatcacttgt cagaagacag tgcctccaaa ggagaaggag    1320

gacccactgg gcaaatacac cttctgggag gtggacctga aagagaagtt ctctgctgac    1380

ctggaccagt ttccactggg caggaagttc ctgctccaag caggactgaa agccaagcca    1440

aaactgaaaa gggctgcccc aaccagcacc aggacctcct ctgccaagag gaagaaggtg    1500

aagaagtaaa ctcgagctc                                                 1519


<210> 7
<211> 35
<212> DNA
<213> 人工序列


<220> 
<223> HPV11L1 F1

<400> 7
cttggtacca tgtggagacc atctgacagc acagt                                35


<210> 8
<211> 36
<212> DNA
<213> 人工序列


<220> 
<223> HPV11L1 R1

<400> 8
gcttggcttt gtagccagat tggagcagga acttcc                               36


<210> 9
<211> 1429
<212> DNA
<213> 人工序列


<220> 
<223> HPV11L1扩增序列1

<400> 9
cttggtacca tgtggagacc atctgacagc acagtctatg tgcctcctcc aaaccctgtg      60

agcaaggtgg tggctacaga tgcctatgtg aagaggacca acatcttcta ccatgcctcc     120

tccagcagac tgctggctgt gggacaccca tactacagca tcaagaaggt gaacaagaca     180

gtggtgccaa aggtgtctgg ctaccaatac agggtgttca aggtggtgct gcctgaccca     240

aacaagtttg ccctgcctga ctcctccctg tttgacccaa ccacccagag actggtgtgg     300

gcttgtactg gattggaggt gggcagggga caaccactgg gagtgggagt gtctggacac     360

ccactgctga acaaatatga tgatgtggag aactctggag gctatggagg caaccctgga     420

caagacaaca gggtgaatgt ggggatggac tacaagcaga cccaactttg tatggtgggc     480

tgtgcccctc cactgggaga acactggggc aagggcaccc agtgtagcaa cacctctgtc     540

cagaatggag actgtcctcc attggaactg attacctctg tgattcagga tggagatatg     600

gtggacacag gctttggagc tatgaacttt gctgacctcc aaaccaacaa gtctgatgtg     660

ccactggaca tctgtggcac agtgtgtaaa taccctgact acctccaaat ggctgctgac     720

ccatatggag acagactgtt cttctacctg aggaaggaac agatgtttgc cagacacttc     780

ttcaacaggg ctggcacagt gggagaacct gtgcctgatg acctgctggt gaagggaggc     840

aacaacaggt cctctgtggc atccagcatc tatgtgcata caccatctgg ctccctggtg     900

tcctctgagg ctcaactttt caacaagcca tactggctcc aaaaggctca aggacacaac     960

aatggcatct gttggggcaa ccacctgttt gtgacagtgg tggacaccac caggagcacc    1020

aatatgaccc tgtgtgcctc tgtgagcaag tctgccacct acaccaactc tgactacaag    1080

gaatatatga ggcatgtgga ggagtttgac ctccaattca tcttccaact ttgtagcatc    1140

accctgtctg ctgaggtgat ggcttacatc cacacaatga acccatctgt gttggaggac    1200

tggaactttg gactgagccc tcctccaaat ggcaccttgg aggacaccta cagatatgtc    1260

cagagccagg ctatcacttg tcagaagcca acacctgaga aggagaagca ggacccatac    1320

aaggatatga gtttctggga ggtgaacctg aaagagaagt tctcctctga actggaccag    1380

tttccactgg gcaggaagtt cctgctccaa tctggctaca aagccaagc                1429


<210> 10
<211> 35
<212> DNA
<213> 人工序列


<220> 
<223> HPV11L1 F2

<400> 10
atctggctac aaagccaagc caaaactgaa aaggg                                35


<210> 11
<211> 37
<212> DNA
<213> 人工序列


<220> 
<223> HPV11L1 R2

<400> 11
ctgtctagat ttacttcttc accttcttcc tcttggc                              37


<210> 12
<211> 101
<212> DNA
<213> 人工序列


<220> 
<223> HPV11L1扩增序列2

<400> 12
atctggctac aaagccaagc caaaactgaa aagggctgcc ccaaccagca ccaggacctc     60

ctctgccaag aggaagaagg tgaagaagta aatctagaca g                        101


<210> 13
<211> 38
<212> PRT
<213> 智人


<220> 
<223> HPV 59型L1蛋白的471-508氨基酸序列

<400> 13
Leu Gln Leu Gly Ala Arg Pro Lys Pro Thr Ile Gly Pro Arg Lys Arg 
1               5                   10                  15      
Ala Ala Pro Ala Pro Thr Ser Thr Pro Ser Pro Lys Arg Val Lys Arg 
            20                  25                  30          
Arg Lys Ser Ser Arg Lys 
        35              

<210> 14
<211> 474
<212> PRT
<213> 智人


<220> 
<223> C端截短的HPV16L1（1-474）氨基酸序列

<400> 14
Met Ser Leu Trp Leu Pro Ser Glu Ala Thr Val Tyr Leu Pro Pro Val 
1               5                   10                  15      
Pro Val Ser Lys Val Val Ser Thr Asp Glu Tyr Val Ala Arg Thr Asn 
            20                  25                  30          
Ile Tyr Tyr His Ala Gly Thr Ser Arg Leu Leu Ala Val Gly His Pro 
        35                  40                  45              
Tyr Phe Pro Ile Lys Lys Pro Asn Asn Asn Lys Ile Leu Val Pro Lys 
    50                  55                  60                  
Val Ser Gly Leu Gln Tyr Arg Val Phe Arg Ile His Leu Pro Asp Pro 
65                  70                  75                  80  
Asn Lys Phe Gly Phe Pro Asp Thr Ser Phe Tyr Asn Pro Asp Thr Gln 
                85                  90                  95      
Arg Leu Val Trp Ala Cys Val Gly Val Glu Val Gly Arg Gly Gln Pro 
            100                 105                 110         
Leu Gly Val Gly Ile Ser Gly His Pro Leu Leu Asn Lys Leu Asp Asp 
        115                 120                 125             
Thr Glu Asn Ala Ser Ala Tyr Ala Ala Asn Ala Gly Val Asp Asn Arg 
    130                 135                 140                 
Glu Cys Ile Ser Met Asp Tyr Lys Gln Thr Gln Leu Cys Leu Ile Gly 
145                 150                 155                 160 
Cys Lys Pro Pro Ile Gly Glu His Trp Gly Lys Gly Ser Pro Cys Thr 
                165                 170                 175     
Asn Val Ala Val Asn Pro Gly Asp Cys Pro Pro Leu Glu Leu Ile Asn 
            180                 185                 190         
Thr Val Ile Gln Asp Gly Asp Met Val Asp Thr Gly Phe Gly Ala Met 
        195                 200                 205             
Asp Phe Thr Thr Leu Gln Ala Asn Lys Ser Glu Val Pro Leu Asp Ile 
    210                 215                 220                 
Cys Thr Ser Ile Cys Lys Tyr Pro Asp Tyr Ile Lys Met Val Ser Glu 
225                 230                 235                 240 
Pro Tyr Gly Asp Ser Leu Phe Phe Tyr Leu Arg Arg Glu Gln Met Phe 
                245                 250                 255     
Val Arg His Leu Phe Asn Arg Ala Gly Ala Val Gly Glu Asn Val Pro 
            260                 265                 270         
Asp Asp Leu Tyr Ile Lys Gly Ser Gly Ser Thr Ala Asn Leu Ala Ser 
        275                 280                 285             
Ser Asn Tyr Phe Pro Thr Pro Ser Gly Ser Met Val Thr Ser Asp Ala 
    290                 295                 300                 
Gln Ile Phe Asn Lys Pro Tyr Trp Leu Gln Arg Ala Gln Gly His Asn 
305                 310                 315                 320 
Asn Gly Ile Cys Trp Gly Asn Gln Leu Phe Val Thr Val Val Asp Thr 
                325                 330                 335     
Thr Arg Ser Thr Asn Met Ser Leu Cys Ala Ala Ile Ser Thr Ser Glu 
            340                 345                 350         
Thr Thr Tyr Lys Asn Thr Asn Phe Lys Glu Tyr Leu Arg His Gly Glu 
        355                 360                 365             
Glu Tyr Asp Leu Gln Phe Ile Phe Gln Leu Cys Lys Ile Thr Leu Thr 
    370                 375                 380                 
Ala Asp Val Met Thr Tyr Ile His Ser Met Asn Ser Thr Ile Leu Glu 
385                 390                 395                 400 
Asp Trp Asn Phe Gly Leu Gln Pro Pro Pro Gly Gly Thr Leu Glu Asp 
                405                 410                 415     
Thr Tyr Arg Phe Val Thr Ser Gln Ala Ile Ala Cys Gln Lys His Thr 
            420                 425                 430         
Pro Pro Ala Pro Lys Glu Asp Pro Leu Lys Lys Tyr Thr Phe Trp Glu 
        435                 440                 445             
Val Asn Leu Lys Glu Lys Phe Ser Ala Asp Leu Asp Gln Phe Pro Leu 
    450                 455                 460                 
Gly Arg Lys Phe Leu Leu Gln Ala Gly Leu 
465                 470                 

