               SEQUENCE LISTING

<110> ϸ޹˾

<120> ԴVEGF FabƬμ;

<130> CIE200066PCT

<160> 55

<170> BiSSAP 1.3.6

<210> 1
<211> 191
<212> PRT
<213> Artificial Sequence


<220> 
<223> VEGF(UniProtKB P15692)Met1-Arg191

<400> 1
Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      
Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          
Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              
Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  
Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  
Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      
Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         
Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             
Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Lys Lys Ser Val 
    130                 135                 140                 
Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys Arg Lys Lys Ser Arg Tyr 
145                 150                 155                 160 
Lys Ser Trp Ser Val Tyr Val Gly Ala Arg Cys Cys Leu Met Pro Trp 
                165                 170                 175     
Ser Leu Pro Gly Pro His Pro Cys Gly Pro Cys Ser Glu Arg Arg 
            180                 185                 190     

<210> 2
<211> 54
<212> DNA
<213> Artificial Sequence


<220> 
<223> ɾ忹ʱÿscFvĽͷ

<400> 2
tctagtggtg gcggtggttc gggcggtggt ggaggtggta gttctagatc ttcc           54


<210> 3
<211> 738
<212> DNA
<213> Artificial Sequence


<220> 
<223> ÿVEGF165-R988 scFv

<400> 3
gagctcgatc tgacccagac tccatccccc gtgtctgcgg ctgttggagg cacagtcacc      60

atcaattgcc agtccagtca gactatttat gctaacaggc gcttagcctg gtatcaacag     120

aaaccagggc agcctcccaa gctcctgatc tatggtgcat ccactctggc atctggggtc     180

ccatcgcggt tcaaaggcag tggatctggg acacagttca ctctcaccat cagcggcgtg     240

cagtgtgacg atgctgccac ttactactgt gcaggctata aaagttatga tggtgatgat     300

gttggtttcg gcggagggac cgaggtggtc gtcaaatcta gtggtggcgg tggttcgggc     360

ggtggtggag gtggtagttc tagatcttcc cagtcggtgg aggagtccgg gggtcgcctg     420

gtaacgcctg ggacacccct gacactcacc tgcacagtct ctggaatcga cctcagtagc     480

tatgcaataa gctgggtccg ccaggctcca gggaaggggc tggaatacat cggatacatt     540

tggaatgctg gtaacaccta ctacgcgagc tgggcaaaag gccgattcac catctccaaa     600

acctcgacca cggtggatct gaaaatcacc agtccgacaa ccgaggacac ggccacctat     660

ttctgtgcca gaggaacatt aggggactac aatggcatgg acccctgggg cccagggacc     720

ctcgtcaccg tctcttca                                                   738


<210> 4
<211> 348
<212> DNA
<213> Artificial Sequence


<220> 
<223> ÿVEGF165-R988ɱ

<400> 4
cagtcggtgg aggagtccgg gggtcgcctg gtaacgcctg ggacacccct gacactcacc      60

tgcacagtct ctggaatcga cctcagtagc tatgcaataa gctgggtccg ccaggctcca     120

gggaaggggc tggaatacat cggatacatt tggaatgctg gtaacaccta ctacgcgagc     180

tgggcaaaag gccgattcac catctccaaa acctcgacca cggtggatct gaaaatcacc     240

agtccgacaa ccgaggacac ggccacctat ttctgtgcca gaggaacatt aggggactac     300

aatggcatgg acccctgggg cccagggacc ctcgtcaccg tctcttca                  348


<210> 5
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ÿVEGF165-R988ɱ

<400> 5
gagctcgatc tgacccagac tccatccccc gtgtctgcgg ctgttggagg cacagtcacc      60

atcaattgcc agtccagtca gactatttat gctaacaggc gcttagcctg gtatcaacag     120

aaaccagggc agcctcccaa gctcctgatc tatggtgcat ccactctggc atctggggtc     180

ccatcgcggt tcaaaggcag tggatctggg acacagttca ctctcaccat cagcggcgtg     240

cagtgtgacg atgctgccac ttactactgt gcaggctata aaagttatga tggtgatgat     300

gttggtttcg gcggagggac cgaggtggtc gtcaaa                               336


<210> 6
<211> 972
<212> DNA
<213> Artificial Sequence


<220> 
<223> IgG1㶨

<400> 6
ggtcaaccta aggctccgtc agtcttccca ctggccccct gctgcgggga cacacccagc      60

tccacggtga ccctgggctg cctggtcaaa ggctacctcc cggagccagt gaccgtgacc     120

tggaactcgg gcaccctcac caatggggta cgcaccttcc cgtccgtccg gcagtcctca     180

ggcctctact cgctgagcag cgtggtgagc gtgacctcaa gcagccagcc cgtcacctgc     240

aacgtggccc acccagccac caacaccaaa gtggacaaga ccgttgcgcc ctcgacatgc     300

agcaagccca cgtgcccacc ccctgaactc ctggggggac cgtctgtctt catcttcccc     360

ccaaaaccca aggacaccct catgatctca cgcacccccg aggtcacatg cgtggtggtg     420

gacgtgagcc aggatgaccc cgaggtgcag ttcacatggt acataaacaa cgagcaggtg     480

cgcaccgccc ggccgccgct acgggagcag cagttcaaca gcacgatccg cgtggtcagc     540

accctcccca tcgcgcacca ggactggctg aggggcaagg agttcaagtg caaagtccac     600

aacaaggcac tcccggcccc catcgagaaa accatctcca aagccagagg gcagcccctg     660

gagccgaagg tctacaccat gggccctccc cgggaggagc tgagcagcag gtcggtcagc     720

ctgacctgca tgatcaacgg cttctaccct tccgacatct cggtggagtg ggagaagaac     780

gggaaggcag aggacaacta caagaccacg ccggccgtgc tggacagcga cggctcctac     840

ttcctctaca gcaagctctc agtgcccacg agtgagtggc agcggggcga cgtcttcacc     900

tgctccgtga tgcacgaggc cttgcacaac cactacacgc agaagtccat ctcccgctct     960

ccgggtaaat aa                                                         972


<210> 7
<211> 315
<212> DNA
<213> Artificial Sequence


<220> 
<223> kappa㶨

<400> 7
ggggatccag ttgcacctac tgtcctcatc ttcccaccag ctgctgatca ggtggcaact     60

ggaacagtca ccatcgtgtg tgtggcgaat aaatactttc ccgatgtcac cgtcacctgg    120

gaggtggatg gcaccaccca aacaactggc atcgagaaca gtaaaacacc gcagaattct    180

gcagattgta cctacaacct cagcagcact ctgacactga ccagcacaca gtacaacagc    240

cacaaagagt acacctgcaa ggtgacccag ggcacgacct cagtcgtcca gagcttcaat    300

aggggtgact gttaa                                                     315


<210> 8
<211> 116
<212> PRT
<213> Artificial Sequence


<220> 
<223> ÿVEGF165-R988ɱ

<400> 8
Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      
Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr Ala 
            20                  25                  30          
Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              
Tyr Ile Trp Asn Ala Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  
Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  
Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Thr 
                85                  90                  95      
Leu Gly Asp Tyr Asn Gly Met Asp Pro Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser 
        115     

<210> 9
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ÿVEGF165-R988ɱ

<400> 9
Glu Leu Asp Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      
Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Thr Ile Tyr Ala Asn 
            20                  25                  30          
Arg Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  
Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  
Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Tyr Lys Ser Tyr 
                85                  90                  95      
Asp Gly Asp Asp Val Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         



<210> 10
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ÿVEGF165-R988CDR1

<400> 10
Gln Ser Ser Gln Thr Ile Tyr Ala Asn Arg Arg Leu Ala 
1               5                   10              

<210> 11
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ÿVEGF165-R988CDR2

<400> 11
Gly Ala Ser Thr Leu Ala Ser 
1               5           

<210> 12
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> ÿVEGF165-R988CDR3

<400> 12
Ala Gly Tyr Lys Ser Tyr Asp Gly Asp Asp Val Gly 
1               5                   10          

<210> 13
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> ÿVEGF165-R988CDR1

<400> 13
Gly Ile Asp Leu Ser Ser Tyr Ala Ile Ser 
1               5                   10  

<210> 14
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ÿVEGF165-R988CDR2

<400> 14
Tyr Ile Trp Asn Ala Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      



<210> 15
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ÿVEGF165-R988CDR3

<400> 15
Ala Arg Gly Thr Leu Gly Asp Tyr Asn Gly Met Asp Pro 
1               5                   10              

<210> 16
<211> 1404
<212> DNA
<213> Artificial Sequence


<220> 
<223> źĵԴVEGF165-H988-10

<400> 16
atgggctggt ccctgattct gctgttcctg gtggctgtgg ctaccagggt gctgagtcag      60

tctgtccagg agtctggacc tggactggtg aagccatctg agaccctgtc cctgacttgt     120

actgtgtctg gcattgacct gtcctcctat gccatctcct gggtgagaca acctcctggc     180

aagggattgg aatacattgg ctacatctgg aatgctggca acacctacta tgcctcctgg     240

gctaagggca gggtgaccat ctctgtggac accagcaaga accaggtgga cctgaaactg     300

tcctctgtga cagcagcaga cacagcagtc tacttctgtg ccaggggcac cctgggagac     360

tacaatggga tggacccatg gggacctggc accctggtga cagtgtccag cgctagcacc     420

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg     480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca     540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac     600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc     660

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt     720

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc     780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg     840

tgcgtggtgg tggacgtgag ccacgaagac cccgaggtca agttcaactg gtacgtggac     900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag    1020

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa    1080

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag    1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag    1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc    1260

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg    1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc    1380

ctctccctgt ctccgggtaa atga                                           1404


<210> 17
<211> 717
<212> DNA
<213> Artificial Sequence


<220> 
<223> źĵԴVEGF165-H988-10

<400> 17
atgggctggt cctgtatcat cctgttcctg gtggctacag ccacaggagt gcatagtgaa      60

ctccaactta cccagagccc atcctccctg tctgcctctg tgggagacag ggtgaccatc     120

acttgtcagt ccagccagac catctatgcc aacaggagac tggcttggta tcaacagaag     180

cctggcaagg tgccaaaact gctgatttat ggagccagca ccctggcatc tggagtgcca     240

agcaggttca agggctctgg ctctggcaca gacttcaccc tgaccatctc ctccctccaa     300

cctgaggatg tggctaccta ctactgtgct ggctacaagt cctatgatgg agatgatgtg     360

ggctttggag gaggcaccaa ggtggagatt aagcgtacgg tggctgcacc atctgtcttc     420

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg     480

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg     540

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc     600

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc     660

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgttag        717


<210> 18
<211> 467
<212> PRT
<213> Artificial Sequence


<220> 
<223> źĵԴVEGF165-H988-10

<400> 18
Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      
Val Leu Ser Gln Ser Val Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          
Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser 
        35                  40                  45              
Ser Tyr Ala Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  
Tyr Ile Gly Tyr Ile Trp Asn Ala Gly Asn Thr Tyr Tyr Ala Ser Trp 
65                  70                  75                  80  
Ala Lys Gly Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val 
                85                  90                  95      
Asp Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
            100                 105                 110         
Cys Ala Arg Gly Thr Leu Gly Asp Tyr Asn Gly Met Asp Pro Trp Gly 
        115                 120                 125             
Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 
Pro Gly Lys 
465         

<210> 19
<211> 238
<212> PRT
<213> Artificial Sequence


<220> 
<223> źĵԴVEGF165-H988-10

<400> 19
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Glu Leu Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Thr Ile 
        35                  40                  45              
Tyr Ala Asn Arg Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val 
    50                  55                  60                  
Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  
Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      
Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Ala Gly Tyr 
            100                 105                 110         
Lys Ser Tyr Asp Gly Asp Asp Val Gly Phe Gly Gly Gly Thr Lys Val 
        115                 120                 125             
Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 
Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             

<210> 20
<211> 354
<212> DNA
<213> Artificial Sequence


<220> 
<223> ԴVEGF165-H988-10ɱ

<400> 20
cagtctgtcc aggagtctgg acctggactg gtgaagccat ctgagaccct gtccctgact      60

tgtactgtgt ctggcattga cctgtcctcc tatgccatct cctgggtgag acaacctcct     120

ggcaagggat tggaatacat tggctacatc tggaatgctg gcaacaccta ctatgcctcc     180

tgggctaagg gcagggtgac catctctgtg gacaccagca agaaccaggt ggacctgaaa     240

ctgtcctctg tgacagcagc agacacagca gtctacttct gtgccagggg caccctggga     300

gactacaatg ggatggaccc atggggacct ggcaccctgg tgacagtgtc cagc           354


<210> 21
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ԴVEGF165-H988-10 ɱ

<400> 21
gaactccaac ttacccagag cccatcctcc ctgtctgcct ctgtgggaga cagggtgacc      60

atcacttgtc agtccagcca gaccatctat gccaacagga gactggcttg gtatcaacag     120

aagcctggca aggtgccaaa actgctgatt tatggagcca gcaccctggc atctggagtg     180

ccaagcaggt tcaagggctc tggctctggc acagacttca ccctgaccat ctcctccctc     240

caacctgagg atgtggctac ctactactgt gctggctaca agtcctatga tggagatgat     300

gtgggctttg gaggaggcac caaggtggag attaag                               336


<210> 22
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> VEGF165-H988-10ɱ

<400> 22
Gln Ser Val Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
1               5                   10                  15      
Leu Ser Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr Ala 
            20                  25                  30          
Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              
Tyr Ile Trp Asn Ala Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  
Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Asp Leu Lys 
65                  70                  75                  80  
Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala Arg 
                85                  90                  95      
Gly Thr Leu Gly Asp Tyr Asn Gly Met Asp Pro Trp Gly Pro Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 23
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> VEGF165-H988-10ɱ

<400> 23
Glu Leu Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Thr Ile Tyr Ala Asn 
            20                  25                  30          
Arg Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  
Lys Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  
Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Ala Gly Tyr Lys Ser Tyr 
                85                  90                  95      
Asp Gly Asp Asp Val Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         



<210> 24
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ԴVEGF-H988 FabCDR1

<400> 24
Gln Ser Ser Lys Phe Leu Trp Gln Gly Arg Arg Leu Ala 
1               5                   10              

<210> 25
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> ԴVEGF-H988 FabCDR2

<400> 25
Gly Ala Ser Thr Leu Ala Ser 
1               5           

<210> 26
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> ԴVEGF-H988 FabCDR3

<400> 26
Ala Gly Tyr Lys Ser Tyr Asp Gly Asp Val Val Gly 
1               5                   10          

<210> 27
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> ԴVEGF-H988 FabCDR1

<400> 27
Gly Ile Asp Leu Ser Ser Tyr Ala Ile Ser 
1               5                   10  

<210> 28
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> ԴVEGF-H988 FabCDR2

<400> 28
Tyr Ile Trp Asn Asp Leu Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      



<210> 29
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ԴVEGF-H988 FabCDR3

<400> 29
Ala Arg Gly Thr Leu Gly Asp Tyr Gly Gly Met Asp Pro 
1               5                   10              

<210> 30
<211> 221
<212> PRT
<213> Artificial Sequence


<220> 
<223> ԴVEGF-H988 Fab

<400> 30
Gln Ser Val Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
1               5                   10                  15      
Leu Ser Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr Ala 
            20                  25                  30          
Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              
Tyr Ile Trp Asn Asp Leu Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  
Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Asp Leu Lys 
65                  70                  75                  80  
Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala Arg 
                85                  90                  95      
Gly Thr Leu Gly Asp Tyr Gly Gly Met Asp Pro Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220     

<210> 31
<211> 219
<212> PRT
<213> Artificial Sequence


<220> 
<223> ԴVEGF-H988 Fab

<400> 31
Glu Leu Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Lys Phe Leu Trp Gln Gly 
            20                  25                  30          
Arg Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  
Lys Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  
Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Ala Gly Tyr Lys Ser Tyr 
                85                  90                  95      
Asp Gly Asp Val Val Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 

<210> 32
<211> 240
<212> PRT
<213> Artificial Sequence


<220> 
<223> źĵԴVEGF-H988 Fab

<400> 32
Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      
Val Leu Ser Gln Ser Val Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          
Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser 
        35                  40                  45              
Ser Tyr Ala Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  
Tyr Ile Gly Tyr Ile Trp Asn Asp Leu Phe Thr Tyr Tyr Ala Ser Trp 
65                  70                  75                  80  
Ala Lys Gly Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val 
                85                  90                  95      
Asp Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
            100                 105                 110         
Cys Ala Arg Gly Thr Leu Gly Asp Tyr Gly Gly Met Asp Pro Trp Gly 
        115                 120                 125             
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 



<210> 33
<211> 238
<212> PRT
<213> Artificial Sequence


<220> 
<223> źĵԴVEGF-H988 Fab

<400> 33
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Glu Leu Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Lys Phe Leu 
        35                  40                  45              
Trp Gln Gly Arg Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val 
    50                  55                  60                  
Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  
Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      
Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Ala Gly Tyr 
            100                 105                 110         
Lys Ser Tyr Asp Gly Asp Val Val Gly Phe Gly Gly Gly Thr Lys Val 
        115                 120                 125             
Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 
Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             

<210> 34
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> źİ

<400> 34
Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      
Val Leu Ser 
            

<210> 35
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> źİ

<400> 35
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser 
            

<210> 36
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> ԴVEGF-H988 Fabɱ

<400> 36
Gln Ser Val Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
1               5                   10                  15      
Leu Ser Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser Tyr Ala 
            20                  25                  30          
Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              
Tyr Ile Trp Asn Asp Leu Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  
Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Asp Leu Lys 
65                  70                  75                  80  
Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala Arg 
                85                  90                  95      
Gly Thr Leu Gly Asp Tyr Gly Gly Met Asp Pro Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 37
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> ԴVEGF-H988 Fabɱ

<400> 37
Glu Leu Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Lys Phe Leu Trp Gln Gly 
            20                  25                  30          
Arg Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  
Lys Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  
Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Ala Gly Tyr Lys Ser Tyr 
                85                  90                  95      
Asp Gly Asp Val Val Gly Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         



<210> 38
<211> 330
<212> PRT
<213> Artificial Sequence


<220> 
<223> IgG1㶨

<400> 38
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210> 39
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Kappa㶨

<400> 39
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         

<210> 40
<211> 103
<212> PRT
<213> Artificial Sequence


<220> 
<223> IgG1CH1㶨İ

<400> 40
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys 
            100             

<210> 41
<211> 723
<212> DNA
<213> Artificial Sequence


<220> 
<223> źĵԴVEGF-H988 Fab

<400> 41
atgggctggt ccctgattct gctgttcctg gtggctgtgg ctaccagggt gctgagtcag      60

tctgtccagg agtctggacc tggactggtg aagccatctg agaccctgtc cctgacttgt     120

actgtgtctg gcattgacct gtcctcctat gccatctcct gggtgagaca acctcctggc     180

aagggattgg aatacattgg ctacatctgg aatgatctct tcacctacta tgcctcctgg     240

gctaagggca gggtgaccat ctctgtggac accagcaaga accaggtgga cctgaaactg     300

tcctctgtga cagcagcaga cacagcagtc tacttctgtg ccaggggcac cctgggagac     360

tacggcggga tggacccatg gggacagggc accctggtga cagtgtccag cgcaagcacc     420

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg     480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca     540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac     600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc     660

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt     720

taa                                                                   723


<210> 42
<211> 717
<212> DNA
<213> Artificial Sequence


<220> 
<223> źĵԴVEGF-H988 Fab

<400> 42
atgggctggt cctgtatcat cctgttcctg gtggctacag ccacaggagt gcatagtgaa      60

ctccaactta cccagagccc atcctccctg tctgcctctg tgggagacag ggtgaccatc     120

acttgtcagt ccagcaagtt cctctggcag ggcaggagac tggcttggta tcaacagaag     180

cctggcaagg tgccaaaact gctgatttat ggagccagca ccctggcatc tggagtgcca     240

agcaggttca agggctctgg ctctggcaca gacttcaccc tgaccatctc ctccctccaa     300

cctgaggatg tggctaccta ctactgtgct ggctacaagt cctatgatgg agatgttgtg     360

ggctttggag gaggcaccaa ggtggagatt aagcgtacgg tggctgcacc atctgtcttc     420

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg     480

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg     540

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc     600

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc     660

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgttaa        717


<210> 43
<211> 57
<212> DNA
<213> Artificial Sequence


<220> 
<223> źĺ

<400> 43
atgggctggt ccctgattct gctgttcctg gtggctgtgg ctaccagggt gctgagt        57


<210> 44
<211> 57
<212> DNA
<213> Artificial Sequence


<220> 
<223> źĺ

<400> 44
atgggctggt cctgtatcat cctgttcctg gtggctacag ccacaggagt gcatagt        57


<210> 45
<211> 354
<212> DNA
<213> Artificial Sequence


<220> 
<223> ԴVEGF-H988 Fabɱ

<400> 45
cagtctgtcc aggagtctgg acctggactg gtgaagccat ctgagaccct gtccctgact      60

tgtactgtgt ctggcattga cctgtcctcc tatgccatct cctgggtgag acaacctcct     120

ggcaagggat tggaatacat tggctacatc tggaatgatc tcttcaccta ctatgcctcc     180

tgggctaagg gcagggtgac catctctgtg gacaccagca agaaccaggt ggacctgaaa     240

ctgtcctctg tgacagcagc agacacagca gtctacttct gtgccagggg caccctggga     300

gactacggcg ggatggaccc atggggacag ggcaccctgg tgacagtgtc cagc           354


<210> 46
<211> 336
<212> DNA
<213> Artificial Sequence


<220> 
<223> ԴVEGF-H988 Fabɱ

<400> 46
gaactccaac ttacccagag cccatcctcc ctgtctgcct ctgtgggaga cagggtgacc      60

atcacttgtc agtccagcaa gttcctctgg cagggcagga gactggcttg gtatcaacag     120

aagcctggca aggtgccaaa actgctgatt tatggagcca gcaccctggc atctggagtg     180

ccaagcaggt tcaagggctc tggctctggc acagacttca ccctgaccat ctcctccctc     240

caacctgagg atgtggctac ctactactgt gctggctaca agtcctatga tggagatgtt     300

gtgggctttg gaggaggcac caaggtggag attaag                               336


<210> 47
<211> 993
<212> DNA
<213> Artificial Sequence


<220> 
<223>  IgG1 㶨ĺ

<400> 47
gcaagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg     120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca     180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc     240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc     300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga     360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     420

gaggtcacgt gcgtggtggt ggacgtgagc cacgaagacc ccgaggtcaa gttcaactgg     480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag     720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     960

cagaagagcc tctccctgtc tccgggtaaa taa                                  993


<210> 48
<211> 324
<212> DNA
<213> Artificial Sequence


<220> 
<223> kappa㶨ĺ

<400> 48
cgtacggtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct      60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag     120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac     180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag     240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag     300

agcttcaaca ggggagagtg ttaa                                            324


<210> 49
<211> 312
<212> DNA
<213> Artificial Sequence


<220> 
<223> IgG1CH1㶨ĺ

<400> 49
gcaagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc    300

aaatcttgtt aa                                                        312


<210> 50
<211> 246
<212> PRT
<213> Artificial Sequence


<220> 
<223> ÿVEGF165-R988 scfv

<400> 50
Glu Leu Asp Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      
Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Thr Ile Tyr Ala Asn 
            20                  25                  30          
Arg Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  
Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  
Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Tyr Lys Ser Tyr 
                85                  90                  95      
Asp Gly Asp Asp Val Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Ser Arg 
        115                 120                 125             
Ser Ser Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly 
    130                 135                 140                 
Thr Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser Ser 
145                 150                 155                 160 
Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr 
                165                 170                 175     
Ile Gly Tyr Ile Trp Asn Ala Gly Asn Thr Tyr Tyr Ala Ser Trp Ala 
            180                 185                 190         
Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys 
        195                 200                 205             
Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
    210                 215                 220                 
Gly Thr Leu Gly Asp Tyr Asn Gly Met Asp Pro Trp Gly Pro Gly Thr 
225                 230                 235                 240 
Leu Val Thr Val Ser Ser 
                245     

<210> 51
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> ɾ忹ʱÿscFvĽͷ

<400> 51
Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly Ser Ser Arg 
1               5                   10                  15      
Ser Ser 
        

<210> 52
<211> 1377
<212> DNA
<213> Artificial Sequence


<220> 
<223> źĵÿVEGF165-R988

<400> 52
atgggctggt ccctgattct gctgttcctg gtggctgtgg ctaccagggt gctgagtcag      60

tcggtggagg agtccggggg tcgcctggta acgcctggga cacccctgac actcacctgc     120

acagtctctg gaatcgacct cagtagctat gcaataagct gggtccgcca ggctccaggg     180

aaggggctgg aatacatcgg atacatttgg aatgctggta acacctacta cgcgagctgg     240

gcaaaaggcc gattcaccat ctccaaaacc tcgaccacgg tggatctgaa aatcaccagt     300

ccgacaaccg aggacacggc cacctatttc tgtgccagag gaacattagg ggactacaat     360

ggcatggacc cctggggccc agggaccctc gtcaccgtct cttcaggtca acctaaggct     420

ccgtcagtct tcccactggc cccctgctgc ggggacacac ccagctccac ggtgaccctg     480

ggctgcctgg tcaaaggcta cctcccggag ccagtgaccg tgacctggaa ctcgggcacc     540

ctcaccaatg gggtacgcac cttcccgtcc gtccggcagt cctcaggcct ctactcgctg     600

agcagcgtgg tgagcgtgac ctcaagcagc cagcccgtca cctgcaacgt ggcccaccca     660

gccaccaaca ccaaagtgga caagaccgtt gcgccctcga catgcagcaa gcccacgtgc     720

ccaccccctg aactcctggg gggaccgtct gtcttcatct tccccccaaa acccaaggac     780

accctcatga tctcacgcac ccccgaggtc acatgcgtgg tggtggacgt gagccaggat     840

gaccccgagg tgcagttcac atggtacata aacaacgagc aggtgcgcac cgcccggccg     900

ccgctacggg agcagcagtt caacagcacg atccgcgtgg tcagcaccct ccccatcgcg     960

caccaggact ggctgagggg caaggagttc aagtgcaaag tccacaacaa ggcactcccg    1020

gcccccatcg agaaaaccat ctccaaagcc agagggcagc ccctggagcc gaaggtctac    1080

accatgggcc ctccccggga ggagctgagc agcaggtcgg tcagcctgac ctgcatgatc    1140

aacggcttct acccttccga catctcggtg gagtgggaga agaacgggaa ggcagaggac    1200

aactacaaga ccacgccggc cgtgctggac agcgacggct cctacttcct ctacagcaag    1260

ctctcagtgc ccacgagtga gtggcagcgg ggcgacgtct tcacctgctc cgtgatgcac    1320

gaggccttgc acaaccacta cacgcagaag tccatctccc gctctccggg taaataa       1377


<210> 53
<211> 708
<212> DNA
<213> Artificial Sequence


<220> 
<223> źĵÿVEGF165-R988

<400> 53
atgggctggt cctgtatcat cctgttcctg gtggctacag ccacaggagt gcatagtgag      60

ctcgatctga cccagactcc atcccccgtg tctgcggctg ttggaggcac agtcaccatc     120

aattgccagt ccagtcagac tatttatgct aacaggcgct tagcctggta tcaacagaaa     180

ccagggcagc ctcccaagct cctgatctat ggtgcatcca ctctggcatc tggggtccca     240

tcgcggttca aaggcagtgg atctgggaca cagttcactc tcaccatcag cggcgtgcag     300

tgtgacgatg ctgccactta ctactgtgca ggctataaaa gttatgatgg tgatgatgtt     360

ggtttcggcg gagggaccga ggtggtcgtc aaaggggatc cagttgcacc tactgtcctc     420

atcttcccac cagctgctga tcaggtggca actggaacag tcaccatcgt gtgtgtggcg     480

aataaatact ttcccgatgt caccgtcacc tgggaggtgg atggcaccac ccaaacaact     540

ggcatcgaga acagtaaaac accgcagaat tctgcagatt gtacctacaa cctcagcagc     600

actctgacac tgaccagcac acagtacaac agccacaaag agtacacctg caaggtgacc     660

cagggcacga cctcagtcgt ccagagcttc aataggggtg actgttaa                  708


<210> 54
<211> 458
<212> PRT
<213> Artificial Sequence


<220> 
<223> źĵÿVEGF165-R988

<400> 54
Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Arg 
1               5                   10                  15      
Val Leu Ser Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          
Gly Thr Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Ile Asp Leu Ser 
        35                  40                  45              
Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  
Tyr Ile Gly Tyr Ile Trp Asn Ala Gly Asn Thr Tyr Tyr Ala Ser Trp 
65                  70                  75                  80  
Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu 
                85                  90                  95      
Lys Ile Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
            100                 105                 110         
Arg Gly Thr Leu Gly Asp Tyr Asn Gly Met Asp Pro Trp Gly Pro Gly 
        115                 120                 125             
Thr Leu Val Thr Val Ser Ser Gly Gln Pro Lys Ala Pro Ser Val Phe 
    130                 135                 140                 
Pro Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr Leu 
145                 150                 155                 160 
Gly Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr Trp 
                165                 170                 175     
Asn Ser Gly Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val Arg 
            180                 185                 190         
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr Ser 
        195                 200                 205             
Ser Ser Gln Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr 
    210                 215                 220                 
Lys Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys 
225                 230                 235                 240 
Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
                245                 250                 255     
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         
Val Val Val Asp Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr Trp 
        275                 280                 285             
Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg Glu 
    290                 295                 300                 
Gln Gln Phe Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Ala 
305                 310                 315                 320 
His Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His Asn 
                325                 330                 335     
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly 
            340                 345                 350         
Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu Glu 
        355                 360                 365             
Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr 
    370                 375                 380                 
Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp 
385                 390                 395                 400 
Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe 
                405                 410                 415     
Leu Tyr Ser Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly Asp 
            420                 425                 430         
Val Phe Thr Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        435                 440                 445             
Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys 
    450                 455             

<210> 55
<211> 235
<212> PRT
<213> Artificial Sequence


<220> 
<223> źĵÿVEGF165-R988

<400> 55
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Glu Leu Asp Leu Thr Gln Thr Pro Ser Pro Val Ser Ala 
            20                  25                  30          
Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Thr Ile 
        35                  40                  45              
Tyr Ala Asn Arg Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
    50                  55                  60                  
Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  
Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile 
                85                  90                  95      
Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Tyr 
            100                 105                 110         
Lys Ser Tyr Asp Gly Asp Asp Val Gly Phe Gly Gly Gly Thr Glu Val 
        115                 120                 125             
Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro Pro 
    130                 135                 140                 
Ala Ala Asp Gln Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala 
145                 150                 155                 160 
Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr 
                165                 170                 175     
Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala 
            180                 185                 190         
Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln 
        195                 200                 205             
Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr 
    210                 215                 220                 
Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys 
225                 230                 235 

