                         SEQUENCE LISTING

<110>  The Pennsylvania State University
 
<120>  NANOPORE-BASED DETECTION OF ANALYTES

<130>  36PST96852WO

<150>  US 62/875,235
<151>  2019-07-17

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  50
<212>  DNA
<213>  Human immunodeficiency virus

<400>  1
tatcacctag aactttaaat gcatgggtaa aagtagtaga agagaaggct                  50


<210>  2
<211>  41
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA for HIV

<400>  2
uaauuucuac ucuuguagau aaugcauggg uaaaaguagu a                           41


<210>  3
<211>  51
<212>  DNA
<213>  Human immunodeficiency virus

<400>  3
cctttaactt ccctcaggtc actctttggc aacgacccct cgtcacaata a                51


<210>  4
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  crRNA for HIV

<400>  4
uaauuucuac ucuuguagau acuucccuca ggucacucuu ugg                         43


<210>  5
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Direct Repeat sequence of a crRNA recognized by Cas12

<400>  5
uaauuucuac ucuuguagau                                                   20


<210>  6
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Target-specific sequence including in the crRNA of SEQ ID NO:2

<400>  6
aaugcauggg uaaaaguagu a                                                 21


<210>  7
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Target-specific sequence included in the crRNA of SEQ ID NO:4

<400>  7
acuucccuca ggucacucuu ugg                                               23


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for amplication of SARS-Cov-2

<400>  8
ttacaaacat tggccgcaaa                                                   20


<210>  9
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for amplication of SARS-Cov-2

<400>  9
gcgcgacatt ccgaagaa                                                     18


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  crRNA for SARS-Cov-2

<400>  10
cccccagcgc ttcagcgttc                                                   20


<210>  11
<211>  1300
<212>  PRT
<213>  Francisella tularensis

<400>  11

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  12
<211>  933
<212>  PRT
<213>  Corynebacterium diphtheriae

<400>  12

Met Ser Val Val Asp Gln Ala Asp Gln Trp Arg Arg Ala Arg Ser Val 
1               5                   10                  15      


Gln Ala Tyr Ser Leu Trp Ala Lys Ser Gly Ser Glu Asp Leu Tyr Leu 
            20                  25                  30          


Arg Leu Pro Gln His Leu Ile Asp Ala Ala Cys Val Ala Glu Trp Leu 
        35                  40                  45              


Trp Asn Asn Trp Val Ser Asp Ser Leu Lys Ser Thr Leu Ser Ala Ala 
    50                  55                  60                  


Trp Arg Leu Pro Ala Glu Glu Val Gly Arg Leu Tyr Thr Phe Tyr Ala 
65                  70                  75                  80  


Gly Thr His Asp Val Gly Lys Ala Thr Ile Ser Phe Gln Arg Leu Val 
                85                  90                  95      


Glu Lys Thr Ser His Gly Asn Tyr Leu Leu Gly Pro Val Arg Glu Ala 
            100                 105                 110         


Gly Leu Ser Leu Gln Trp Thr Leu Asn Glu Gly Glu Gly Lys Lys Phe 
        115                 120                 125             


Pro His Gly Met Ala Ser Ala Leu Ile Ile Ala Ala Trp Leu Glu Lys 
    130                 135                 140                 


His Asp Ile Asp Pro Ser Ser Ala Ala Arg Leu Ser Phe Ile Ala Asp 
145                 150                 155                 160 


Ala His His Gly Phe Ala Ser Asp Glu Glu Leu Tyr Arg Ser His Glu 
                165                 170                 175     


Asp Thr Leu Asp Tyr Tyr Pro Pro Glu Trp Leu Val Val His Ala Glu 
            180                 185                 190         


Ile Leu Asp Ser Met Ala Glu Ile Thr Asp Ile Gly Glu Thr Leu Glu 
        195                 200                 205             


Glu Leu Ala Asp Gln Ser Thr Pro Ser Ala Pro Ala Met Gln Ile Met 
    210                 215                 220                 


Thr Gly Leu Val Ile Met Ala Asp Trp Ile Ala Ser Asp Glu Lys Ala 
225                 230                 235                 240 


Phe Pro Tyr Val Cys Asp Ser Ser Gln His Asp Arg Val Val Glu Gly 
                245                 250                 255     


Met Ser His Val Asn Leu Pro Pro Ala Trp Val Pro Thr Asp Val Pro 
            260                 265                 270         


Asp Asn Val Glu Thr Leu Phe Arg Asp Thr Phe Thr Trp Pro Asp Ser 
        275                 280                 285             


Tyr Gln Val Arg Pro Val Gln Arg Ala Ala Val Ala Val Ala Arg Ala 
    290                 295                 300                 


Val Gln Asp Pro Thr Leu Ile Ile Ile Glu Ala Pro Thr Gly Glu Gly 
305                 310                 315                 320 


Lys Thr Glu Ala Gly Leu Ala Thr Ser His Ile Leu Gly Gln Lys Thr 
                325                 330                 335     


Gly Ala Gln Gly Ile Phe Phe Ala Ala Pro Thr Met Ser Thr Ala Asn 
            340                 345                 350         


Gly Leu Phe Glu Arg Thr Lys Asn Trp Ala Gln Cys Thr Ser Ser Arg 
        355                 360                 365             


Gly Glu Val Ala Ser Leu Tyr Leu Ala His Ser Lys Asn Lys Leu Ser 
    370                 375                 380                 


Leu Pro Phe Gln Ser Leu Arg Phe Thr Ser Ile Gly Glu Asp Asp His 
385                 390                 395                 400 


Leu Glu Lys His Gly Ser Val Val Ala Ser Gln Trp Leu Ser Gly Arg 
                405                 410                 415     


His Arg Gly Ile Leu Ser Asp Phe Val Val Gly Thr Val Asp Gln Val 
            420                 425                 430         


Leu Met Met Ala Leu Gln Val Arg Phe Ser Met Leu Arg His Val Gly 
        435                 440                 445             


Leu Ala Gly Lys Ile Val Ile Ile Asp Glu Val His Ala Tyr Asp Ala 
    450                 455                 460                 


Tyr Met Ser Gln Tyr Leu Tyr Leu Thr Leu Gln Trp Leu Ala Lys Tyr 
465                 470                 475                 480 


Gly Val Ser Val Ile Leu Met Ser Ala Thr Leu Pro Pro Gln Gln Arg 
                485                 490                 495     


Ala Arg Leu Val Asn Ala Tyr Ala Ser Gln Val Cys Lys Lys Ala Asp 
            500                 505                 510         


Ala Ser Ala Leu Asn Ser Asp Ala Tyr Pro Leu Ile Thr Ala Val Asn 
        515                 520                 525             


Lys Lys Gly Ile Ser Val Thr Glu Val Pro Gln Glu Asn Ser Asp Thr 
    530                 535                 540                 


Thr Ile Lys Ile Arg Arg Ile Asp Asp Ser Leu Pro Ala Leu Gly Gly 
545                 550                 555                 560 


Met Phe Ser Asp Leu Leu Val Asp Gly Gly Ile Ala Leu Val Ile Cys 
                565                 570                 575     


Asn Thr Ile Arg Arg Ala Gln Gln Ala Tyr Asp Ser Leu Lys Ala Ile 
            580                 585                 590         


Phe Pro Asp Glu Val Glu Leu His His Ala Ala Phe Ile Ala Thr Gln 
        595                 600                 605             


Arg Ser Glu Lys Glu Asp Ala Leu Arg Glu Ser Leu Gly Pro His Ala 
    610                 615                 620                 


Ser Arg Gly Glu Asp Arg Pro Trp Arg Arg Ile Val Val Ala Thr Gln 
625                 630                 635                 640 


Val Ala Glu Gln Ser Leu Asp Ile Asp Ala Asp Val Leu Val Thr Asp 
                645                 650                 655     


Ile Ala Pro Ile Asp Leu Ile Ile Gln Arg Ala Gly Arg Leu His Arg 
            660                 665                 670         


His Glu Arg Pro His Ser Asp Arg Pro Glu Ile Leu Gly Gln Pro Gln 
        675                 680                 685             


Ile Phe Ile Arg Gly Ile Asn Asn Glu Glu Ile Ser Gly Glu Leu Pro 
    690                 695                 700                 


Glu Phe Asp Gly Gly Ala Ala Ala Ile Tyr Gly Glu Lys Ile Leu Tyr 
705                 710                 715                 720 


Ala Thr Val Ala Tyr Leu Pro Asp Glu Phe His Arg Pro Ser Asp Val 
                725                 730                 735     


Pro Lys Leu Val Lys Asn Val Tyr Ser Asp Thr Pro Cys Ile Pro Glu 
            740                 745                 750         


Asn Trp Lys Glu Gln Trp Glu Gln Ala Cys Val Lys Ala Lys Glu Asn 
        755                 760                 765             


Tyr Glu Lys Ser Val Arg Lys Ala Gln Thr Phe Ser Phe Pro Gln Pro 
    770                 775                 780                 


His Met Ala Arg Thr Leu Arg Asp Leu Phe Lys Gln Gln His Ser Asn 
785                 790                 795                 800 


Ser Val Asp Lys Lys Glu Glu Ser Gly Ser Ala Gln Val Arg Asp Ala 
                805                 810                 815     


Glu Phe Ser Ile Glu Val Val Ala Leu Leu Lys Thr Glu Tyr Gly Tyr 
            820                 825                 830         


His Pro Phe Gly Arg Glu Glu Glu Ile Glu Asn Gly Arg Glu Leu Thr 
        835                 840                 845             


Trp Lys Glu Ala Glu Ala Leu Ala Gly Asn Thr Val Arg Leu Pro Ala 
    850                 855                 860                 


Gln Met Thr Arg Arg Asp Ser Asp Phe Asn Ala Val Ile Asp Ser Leu 
865                 870                 875                 880 


Glu Ala Gln Thr Pro Pro Glu Trp Gln Arg Ser Gly Leu Leu Lys Gly 
                885                 890                 895     


Gln Val Ala Leu Phe Phe Asp Glu Arg Gly Glu Ala Arg Leu Gly Arg 
            900                 905                 910         


Phe Leu Val Arg Tyr Thr Asn Glu Arg Gly Leu Glu Val Glu Val Cys 
        915                 920                 925             


Pro Lys Glu Asp Ala 
    930             


<210>  13
<211>  1154
<212>  PRT
<213>  Proteocatella sphenisci

<400>  13

Met Glu Asn Phe Lys Asn Leu Tyr Pro Ile Asn Lys Thr Leu Arg Phe 
1               5                   10                  15      


Glu Leu Arg Pro Tyr Gly Lys Thr Leu Glu Asn Phe Lys Lys Ser Gly 
            20                  25                  30          


Leu Leu Glu Lys Asp Ala Phe Lys Ala Asn Ser Arg Arg Ser Met Gln 
        35                  40                  45              


Ala Ile Ile Asp Glu Lys Phe Lys Glu Thr Ile Glu Glu Arg Leu Lys 
    50                  55                  60                  


Tyr Thr Glu Phe Ser Glu Cys Asp Leu Gly Asn Met Thr Ser Lys Asp 
65                  70                  75                  80  


Lys Lys Ile Thr Asp Lys Ala Ala Thr Asn Leu Lys Lys Gln Val Ile 
                85                  90                  95      


Leu Ser Phe Asp Asp Glu Ile Phe Asn Asn Tyr Leu Lys Pro Asp Lys 
            100                 105                 110         


Asn Ile Asp Ala Leu Phe Lys Asn Asp Pro Ser Asn Pro Val Ile Ser 
        115                 120                 125             


Thr Phe Lys Gly Phe Thr Thr Tyr Phe Val Asn Phe Phe Glu Ile Arg 
    130                 135                 140                 


Lys His Ile Phe Lys Gly Glu Ser Ser Gly Ser Met Ala Tyr Arg Ile 
145                 150                 155                 160 


Ile Asp Glu Asn Leu Thr Thr Tyr Leu Asn Asn Ile Glu Lys Ile Lys 
                165                 170                 175     


Lys Leu Pro Glu Glu Leu Lys Ser Gln Leu Glu Gly Ile Asp Gln Ile 
            180                 185                 190         


Asp Lys Leu Asn Asn Tyr Asn Glu Phe Ile Thr Gln Ser Gly Ile Thr 
        195                 200                 205             


His Tyr Asn Glu Ile Ile Gly Gly Ile Ser Lys Ser Glu Asn Val Lys 
    210                 215                 220                 


Ile Gln Gly Ile Asn Glu Gly Ile Asn Leu Tyr Cys Gln Lys Asn Lys 
225                 230                 235                 240 


Val Lys Leu Pro Arg Leu Thr Pro Leu Tyr Lys Met Ile Leu Ser Asp 
                245                 250                 255     


Arg Val Ser Asn Ser Phe Val Leu Asp Thr Ile Glu Asn Asp Thr Glu 
            260                 265                 270         


Leu Ile Glu Met Ile Ser Asp Leu Ile Asn Lys Thr Glu Ile Ser Gln 
        275                 280                 285             


Asp Val Ile Met Ser Asp Ile Gln Asn Ile Phe Ile Lys Tyr Lys Gln 
    290                 295                 300                 


Leu Gly Asn Leu Pro Gly Ile Ser Tyr Ser Ser Ile Val Asn Ala Ile 
305                 310                 315                 320 


Cys Ser Asp Tyr Asp Asn Asn Phe Gly Asp Gly Lys Arg Lys Lys Ser 
                325                 330                 335     


Tyr Glu Asn Asp Arg Lys Lys His Leu Glu Thr Asn Val Tyr Ser Ile 
            340                 345                 350         


Asn Tyr Ile Ser Glu Leu Leu Thr Asp Thr Asp Val Ser Ser Asn Ile 
        355                 360                 365             


Lys Met Arg Tyr Lys Glu Leu Glu Gln Asn Tyr Gln Val Cys Lys Glu 
    370                 375                 380                 


Asn Phe Asn Ala Thr Asn Trp Met Asn Ile Lys Asn Ile Lys Gln Ser 
385                 390                 395                 400 


Glu Lys Thr Asn Leu Ile Lys Asp Leu Leu Asp Ile Leu Lys Ser Ile 
                405                 410                 415     


Gln Arg Phe Tyr Asp Leu Phe Asp Ile Val Asp Glu Asp Lys Asn Pro 
            420                 425                 430         


Ser Ala Glu Phe Tyr Thr Trp Leu Ser Lys Asn Ala Glu Lys Leu Asp 
        435                 440                 445             


Phe Glu Phe Asn Ser Val Tyr Asn Lys Ser Arg Asn Tyr Leu Thr Arg 
    450                 455                 460                 


Lys Gln Tyr Ser Asp Lys Lys Ile Lys Leu Asn Phe Asp Ser Pro Thr 
465                 470                 475                 480 


Leu Ala Lys Gly Trp Asp Ala Asn Lys Glu Ile Asp Asn Ser Thr Ile 
                485                 490                 495     


Ile Met Arg Lys Phe Asn Asn Asp Arg Gly Asp Tyr Asp Tyr Phe Leu 
            500                 505                 510         


Gly Ile Trp Asn Lys Ser Thr Pro Ala Asn Glu Lys Ile Ile Pro Leu 
        515                 520                 525             


Glu Asp Asn Gly Leu Phe Glu Lys Met Gln Tyr Lys Leu Tyr Pro Asp 
    530                 535                 540                 


Pro Ser Lys Met Leu Pro Lys Gln Phe Leu Ser Lys Ile Trp Lys Ala 
545                 550                 555                 560 


Lys His Pro Thr Thr Pro Glu Phe Asp Lys Lys Tyr Lys Glu Gly Arg 
                565                 570                 575     


His Lys Lys Gly Pro Asp Phe Glu Lys Glu Phe Leu His Glu Leu Ile 
            580                 585                 590         


Asp Cys Phe Lys His Gly Leu Val Asn His Asp Glu Lys Tyr Gln Asp 
        595                 600                 605             


Val Phe Gly Phe Asn Leu Arg Asn Thr Glu Asp Tyr Asn Ser Tyr Thr 
    610                 615                 620                 


Glu Phe Leu Glu Asp Val Glu Arg Cys Asn Tyr Asn Leu Ser Phe Asn 
625                 630                 635                 640 


Lys Ile Ala Asp Thr Ser Asn Leu Ile Asn Asp Gly Lys Leu Tyr Val 
                645                 650                 655     


Phe Gln Ile Trp Ser Lys Asp Phe Ser Ile Asp Ser Lys Gly Thr Lys 
            660                 665                 670         


Asn Leu Asn Thr Ile Tyr Phe Glu Ser Leu Phe Ser Glu Glu Asn Met 
        675                 680                 685             


Ile Glu Lys Met Phe Lys Leu Ser Gly Glu Ala Glu Ile Phe Tyr Arg 
    690                 695                 700                 


Pro Ala Ser Leu Asn Tyr Cys Glu Asp Ile Ile Lys Lys Gly His His 
705                 710                 715                 720 


His Ala Glu Leu Lys Asp Lys Phe Asp Tyr Pro Ile Ile Lys Asp Lys 
                725                 730                 735     


Arg Tyr Ser Gln Asp Lys Phe Phe Phe His Val Pro Met Val Ile Asn 
            740                 745                 750         


Tyr Lys Ser Glu Lys Leu Asn Ser Lys Ser Leu Asn Asn Arg Thr Asn 
        755                 760                 765             


Glu Asn Leu Gly Gln Phe Thr His Ile Ile Gly Ile Asp Arg Gly Glu 
    770                 775                 780                 


Arg His Leu Ile Tyr Leu Thr Val Val Asp Val Ser Thr Gly Glu Ile 
785                 790                 795                 800 


Val Glu Gln Lys His Leu Asp Glu Ile Ile Asn Thr Asp Thr Lys Gly 
                805                 810                 815     


Val Glu His Lys Thr His Tyr Leu Asn Lys Leu Glu Glu Lys Ser Lys 
            820                 825                 830         


Thr Arg Asp Asn Glu Arg Lys Ser Trp Glu Ala Ile Glu Thr Ile Lys 
        835                 840                 845             


Glu Leu Lys Glu Gly Tyr Ile Ser His Val Ile Asn Glu Ile Gln Lys 
    850                 855                 860                 


Leu Gln Glu Lys Tyr Asn Ala Leu Ile Val Met Glu Asn Leu Asn Tyr 
865                 870                 875                 880 


Gly Phe Lys Asn Ser Arg Ile Lys Val Glu Lys Gln Val Tyr Gln Lys 
                885                 890                 895     


Phe Glu Thr Ala Leu Ile Lys Lys Phe Asn Tyr Ile Ile Asp Lys Lys 
            900                 905                 910         


Asp Pro Glu Thr Tyr Ile His Gly Tyr Gln Leu Thr Asn Pro Ile Thr 
        915                 920                 925             


Thr Leu Asp Lys Ile Gly Asn Gln Ser Gly Ile Val Leu Tyr Ile Pro 
    930                 935                 940                 


Ala Trp Asn Thr Ser Lys Ile Asp Pro Val Thr Gly Phe Val Asn Leu 
945                 950                 955                 960 


Leu Tyr Ala Asp Asp Leu Lys Tyr Lys Asn Gln Glu Gln Ala Lys Ser 
                965                 970                 975     


Phe Ile Gln Lys Ile Asp Asn Ile Tyr Phe Glu Asn Gly Glu Phe Lys 
            980                 985                 990         


Phe Asp Ile Asp Phe Ser Lys Trp  Asn Asn Arg Tyr Ser  Ile Ser Lys 
        995                 1000                 1005             


Thr Lys  Trp Thr Leu Thr Ser  Tyr Gly Thr Arg Ile  Gln Thr Phe 
    1010                 1015                 1020             


Arg Asn  Pro Gln Lys Asn Asn  Lys Trp Asp Ser Ala  Glu Tyr Asp 
    1025                 1030                 1035             


Leu Thr  Glu Glu Phe Lys Leu  Ile Leu Asn Ile Asp  Gly Thr Leu 
    1040                 1045                 1050             


Lys Ser  Gln Asp Val Glu Thr  Tyr Lys Lys Phe Met  Ser Leu Phe 
    1055                 1060                 1065             


Lys Leu  Met Leu Gln Leu Arg  Asn Ser Val Thr Gly  Thr Asp Ile 
    1070                 1075                 1080             


Asp Tyr  Met Ile Ser Pro Val  Thr Asp Lys Thr Gly  Thr His Phe 
    1085                 1090                 1095             


Asp Ser  Arg Glu Asn Ile Lys  Asn Leu Pro Ala Asp  Ala Asp Ala 
    1100                 1105                 1110             


Asn Gly  Ala Tyr Asn Ile Ala  Arg Lys Gly Ile Met  Ala Ile Glu 
    1115                 1120                 1125             


Asn Ile  Met Asn Gly Ile Ser  Asp Pro Leu Lys Ile  Ser Asn Glu 
    1130                 1135                 1140             


Asp Tyr  Leu Lys Tyr Ile Gln  Asn Gln Gln Glu 
    1145                 1150                 


<210>  14
<211>  1159
<212>  PRT
<213>  Leptotrichia bucallis

<400>  14

Met Lys Val Thr Lys Val Gly Gly Ile Ser His Lys Lys Tyr Thr Ser 
1               5                   10                  15      


Glu Gly Arg Leu Val Lys Ser Glu Ser Glu Glu Asn Arg Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Ala Leu Leu Asn Met Arg Leu Asp Met Tyr Ile Lys Asn 
        35                  40                  45              


Pro Ser Ser Thr Glu Thr Lys Glu Asn Gln Lys Arg Ile Gly Lys Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Met Val Tyr Leu Lys Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Leu Lys Asn Gly Lys Lys Glu Asn Ile Asp Arg Glu Tyr Ser Glu 
                85                  90                  95      


Thr Asp Ile Leu Glu Ser Asp Val Arg Asp Lys Lys Asn Phe Ala Val 
            100                 105                 110         


Leu Lys Lys Ile Tyr Leu Asn Glu Asn Val Asn Ser Glu Glu Leu Glu 
        115                 120                 125             


Val Phe Arg Asn Asp Ile Lys Lys Lys Leu Asn Lys Ile Asn Ser Leu 
    130                 135                 140                 


Lys Tyr Ser Phe Glu Lys Asn Lys Ala Asn Tyr Gln Lys Ile Asn Glu 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile Ile Tyr 
                165                 170                 175     


Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asp Ala Tyr Val Ser Asn Val 
            180                 185                 190         


Lys Glu Ala Phe Asp Lys Leu Tyr Lys Glu Glu Asp Ile Ala Lys Leu 
        195                 200                 205             


Val Leu Glu Ile Glu Asn Leu Thr Lys Leu Glu Lys Tyr Lys Ile Arg 
    210                 215                 220                 


Glu Phe Tyr His Glu Ile Ile Gly Arg Lys Asn Asp Lys Glu Asn Phe 
225                 230                 235                 240 


Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met Lys Glu 
                245                 250                 255     


Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser Gln Val 
            260                 265                 270         


Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys Asn Ile 
        275                 280                 285             


Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln Leu Leu 
    290                 295                 300                 


Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp Lys Ile 
305                 310                 315                 320 


Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu Asn Lys 
                325                 330                 335     


Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys Tyr Asn 
            340                 345                 350         


Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile Ala Arg 
        355                 360                 365             


Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val Ser Ser 
    370                 375                 380                 


Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn Glu Asn 
385                 390                 395                 400 


Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn Lys Gly 
                405                 410                 415     


Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn Glu Asn 
            420                 425                 430         


Lys Lys Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser Tyr Asp 
        435                 440                 445             


Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala Asn Ile 
    450                 455                 460                 


Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe Asn Leu 
465                 470                 475                 480 


Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala Pro Ser 
                485                 490                 495     


Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys Lys Leu 
            500                 505                 510         


Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe Arg Tyr 
        515                 520                 525             


Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg Phe Glu 
    530                 535                 540                 


Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr 
545                 550                 555                 560 


Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp Lys Thr 
                565                 570                 575     


Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp Ala Gln 
            580                 585                 590         


Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn Tyr Phe 
        595                 600                 605             


Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile Ile Glu 
    610                 615                 620                 


Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr Lys Leu 
625                 630                 635                 640 


Gln Lys Phe Glu Asp Ile Gln Glu Lys Ile Pro Lys Glu Tyr Leu Ala 
                645                 650                 655     


Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp Glu Glu 
            660                 665                 670         


Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly 
        675                 680                 685             


Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile Tyr Ile 
    690                 695                 700                 


Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys Gln Glu 
705                 710                 715                 720 


Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile Lys Ile 
                725                 730                 735     


Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly Asn Ile 
            740                 745                 750         


Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu 
        755                 760                 765             


Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr 
    770                 775                 780                 


Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu Leu Ile 
785                 790                 795                 800 


Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu 
                805                 810                 815     


Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn Lys Val 
            820                 825                 830         


Lys Asp Asn Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile Tyr Phe 
        835                 840                 845             


Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys 
    850                 855                 860                 


Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Gly Tyr 
865                 870                 875                 880 


Lys Ile Ser Ile Glu Glu Leu Lys Lys Tyr Ser Asn Lys Lys Asn Glu 
                885                 890                 895     


Ile Glu Lys Asn His Lys Met Gln Glu Asn Leu His Arg Lys Tyr Ala 
            900                 905                 910         


Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Glu Ser Tyr 
        915                 920                 925             


Lys Gln Ala Ile Glu Asn Ile Glu Glu Tyr Thr His Leu Lys Asn Lys 
    930                 935                 940                 


Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Arg Ile 
945                 950                 955                 960 


Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg 
                965                 970                 975     


Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu Ile 
            980                 985                 990         


Phe Asn Phe Glu Asn Lys Lys Asn  Val Lys Tyr Lys Gly  Gly Gln Ile 
        995                 1000                 1005             


Val Glu  Lys Tyr Ile Lys Phe  Tyr Lys Glu Leu His  Gln Asn Asp 
    1010                 1015                 1020             


Glu Val  Lys Ile Asn Lys Tyr  Ser Ser Ala Asn Ile  Lys Val Leu 
    1025                 1030                 1035             


Lys Gln  Glu Lys Lys Asp Leu  Tyr Ile Arg Asn Tyr  Ile Ala His 
    1040                 1045                 1050             


Phe Asn  Tyr Ile Pro His Ala  Glu Ile Ser Leu Leu  Glu Val Leu 
    1055                 1060                 1065             


Glu Asn  Leu Arg Lys Leu Leu  Ser Tyr Asp Arg Lys  Leu Lys Asn 
    1070                 1075                 1080             


Ala Val  Met Lys Ser Val Val  Asp Ile Leu Lys Glu  Tyr Gly Phe 
    1085                 1090                 1095             


Val Ala  Thr Phe Lys Ile Gly  Ala Asp Lys Lys Ile  Gly Ile Gln 
    1100                 1105                 1110             


Thr Leu  Glu Ser Glu Lys Ile  Val His Leu Lys Asn  Leu Lys Lys 
    1115                 1120                 1125             


Lys Lys  Leu Met Thr Asp Arg  Asn Ser Glu Glu Leu  Cys Lys Leu 
    1130                 1135                 1140             


Val Lys  Ile Met Phe Glu Tyr  Lys Met Glu Glu Lys  Lys Ser Glu 
    1145                 1150                 1155             


Asn 
    


<210>  15
<211>  1182
<212>  PRT
<213>  Leptotrichia wadei

<400>  15

Met Tyr Met Lys Ile Thr Lys Ile Asp Gly Val Ser His Tyr Lys Lys 
1               5                   10                  15      


Gln Asp Lys Gly Ile Leu Lys Lys Lys Trp Lys Asp Leu Asp Glu Arg 
            20                  25                  30          


Lys Gln Arg Glu Lys Ile Glu Ala Arg Tyr Asn Lys Gln Ile Glu Ser 
        35                  40                  45              


Lys Ile Tyr Lys Glu Phe Phe Arg Leu Lys Asn Lys Lys Arg Ile Glu 
    50                  55                  60                  


Lys Glu Glu Asp Gln Asn Ile Lys Ser Leu Tyr Phe Phe Ile Lys Glu 
65                  70                  75                  80  


Leu Tyr Leu Asn Glu Lys Asn Glu Glu Trp Glu Leu Lys Asn Ile Asn 
                85                  90                  95      


Leu Glu Ile Leu Asp Asp Lys Glu Arg Val Ile Lys Gly Tyr Lys Phe 
            100                 105                 110         


Lys Glu Asp Val Tyr Phe Phe Lys Glu Gly Tyr Lys Glu Tyr Tyr Leu 
        115                 120                 125             


Arg Ile Leu Phe Asn Asn Leu Ile Glu Lys Val Gln Asn Glu Asn Arg 
    130                 135                 140                 


Glu Lys Val Arg Lys Asn Lys Glu Phe Leu Asp Leu Lys Glu Ile Phe 
145                 150                 155                 160 


Lys Lys Tyr Lys Asn Arg Lys Ile Asp Leu Leu Leu Lys Ser Ile Asn 
                165                 170                 175     


Asn Asn Lys Ile Asn Leu Glu Tyr Lys Lys Glu Asn Val Asn Glu Glu 
            180                 185                 190         


Ile Tyr Gly Ile Asn Pro Thr Asn Asp Arg Glu Met Thr Phe Tyr Glu 
        195                 200                 205             


Leu Leu Lys Glu Ile Ile Glu Lys Lys Asp Glu Gln Lys Ser Ile Leu 
    210                 215                 220                 


Glu Glu Lys Leu Asp Asn Phe Asp Ile Thr Asn Phe Leu Glu Asn Ile 
225                 230                 235                 240 


Glu Lys Ile Phe Asn Glu Glu Thr Glu Ile Asn Ile Ile Lys Gly Lys 
                245                 250                 255     


Val Leu Asn Glu Leu Arg Glu Tyr Ile Lys Glu Lys Glu Glu Asn Asn 
            260                 265                 270         


Ser Asp Asn Lys Leu Lys Gln Ile Tyr Asn Leu Glu Leu Lys Lys Tyr 
        275                 280                 285             


Ile Glu Asn Asn Phe Ser Tyr Lys Lys Gln Lys Ser Lys Ser Lys Asn 
    290                 295                 300                 


Gly Lys Asn Asp Tyr Leu Tyr Leu Asn Phe Leu Lys Lys Ile Met Phe 
305                 310                 315                 320 


Ile Glu Glu Val Asp Glu Lys Lys Glu Ile Asn Lys Glu Lys Phe Lys 
                325                 330                 335     


Asn Lys Ile Asn Ser Asn Phe Lys Asn Leu Phe Val Gln His Ile Leu 
            340                 345                 350         


Asp Tyr Gly Lys Leu Leu Tyr Tyr Lys Glu Asn Asp Glu Tyr Ile Lys 
        355                 360                 365             


Asn Thr Gly Gln Leu Glu Thr Lys Asp Leu Glu Tyr Ile Lys Thr Lys 
    370                 375                 380                 


Glu Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe Ala Ala Asn 
385                 390                 395                 400 


Ser Tyr Tyr Asn Leu Phe Gly Arg Val Ser Gly Asp Ile Leu Gly Thr 
                405                 410                 415     


Glu Val Val Lys Ser Ser Lys Thr Asn Val Ile Lys Val Gly Ser His 
            420                 425                 430         


Ile Phe Lys Glu Lys Met Leu Asn Tyr Phe Phe Asp Phe Glu Ile Phe 
        435                 440                 445             


Asp Ala Asn Lys Ile Val Glu Ile Leu Glu Ser Ile Ser Tyr Ser Ile 
    450                 455                 460                 


Tyr Asn Val Arg Asn Gly Val Gly His Phe Asn Lys Leu Ile Leu Gly 
465                 470                 475                 480 


Lys Tyr Lys Lys Lys Asp Ile Asn Thr Asn Lys Arg Ile Glu Glu Asp 
                485                 490                 495     


Leu Asn Asn Asn Glu Glu Ile Lys Gly Tyr Phe Ile Lys Lys Arg Gly 
            500                 505                 510         


Glu Ile Glu Arg Lys Val Lys Glu Lys Phe Leu Ser Asn Asn Leu Gln 
        515                 520                 525             


Tyr Tyr Tyr Ser Lys Glu Lys Ile Glu Asn Tyr Phe Glu Val Tyr Glu 
    530                 535                 540                 


Phe Glu Ile Leu Lys Arg Lys Ile Pro Phe Ala Pro Asn Phe Lys Arg 
545                 550                 555                 560 


Ile Ile Lys Lys Gly Glu Asp Leu Phe Asn Asn Lys Asn Asn Lys Lys 
                565                 570                 575     


Tyr Glu Tyr Phe Lys Asn Phe Asp Lys Asn Ser Ala Glu Glu Lys Lys 
            580                 585                 590         


Glu Phe Leu Lys Thr Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn 
        595                 600                 605             


Asn Phe Tyr Lys Glu Phe Leu Ser Lys Lys Glu Glu Phe Glu Lys Ile 
    610                 615                 620                 


Val Leu Glu Val Lys Glu Glu Lys Lys Ser Arg Gly Asn Ile Asn Asn 
625                 630                 635                 640 


Lys Lys Ser Gly Val Ser Phe Gln Ser Ile Asp Asp Tyr Asp Thr Lys 
                645                 650                 655     


Ile Asn Ile Ser Asp Tyr Ile Ala Ser Ile His Lys Lys Glu Met Glu 
            660                 665                 670         


Arg Val Glu Lys Tyr Asn Glu Glu Lys Gln Lys Asp Thr Ala Lys Tyr 
        675                 680                 685             


Ile Arg Asp Phe Val Glu Glu Ile Phe Leu Thr Gly Phe Ile Asn Tyr 
    690                 695                 700                 


Leu Glu Lys Asp Lys Arg Leu His Phe Leu Lys Glu Glu Phe Ser Ile 
705                 710                 715                 720 


Leu Cys Asn Asn Asn Asn Asn Val Val Asp Phe Asn Ile Asn Ile Asn 
                725                 730                 735     


Glu Glu Lys Ile Lys Glu Phe Leu Lys Glu Asn Asp Ser Lys Thr Leu 
            740                 745                 750         


Asn Leu Tyr Leu Phe Phe Asn Met Ile Asp Ser Lys Arg Ile Ser Glu 
        755                 760                 765             


Phe Arg Asn Glu Leu Val Lys Tyr Lys Gln Phe Thr Lys Lys Arg Leu 
    770                 775                 780                 


Asp Glu Glu Lys Glu Phe Leu Gly Ile Lys Ile Glu Leu Tyr Glu Thr 
785                 790                 795                 800 


Leu Ile Glu Phe Val Ile Leu Thr Arg Glu Lys Leu Asp Thr Lys Lys 
                805                 810                 815     


Ser Glu Glu Ile Asp Ala Trp Leu Val Asp Lys Leu Tyr Val Lys Asp 
            820                 825                 830         


Ser Asn Glu Tyr Lys Glu Tyr Glu Glu Ile Leu Lys Leu Phe Val Asp 
        835                 840                 845             


Glu Lys Ile Leu Ser Ser Lys Glu Ala Pro Tyr Tyr Ala Thr Asp Asn 
    850                 855                 860                 


Lys Thr Pro Ile Leu Leu Ser Asn Phe Glu Lys Thr Arg Lys Tyr Gly 
865                 870                 875                 880 


Thr Gln Ser Phe Leu Ser Glu Ile Gln Ser Asn Tyr Lys Tyr Ser Lys 
                885                 890                 895     


Val Glu Lys Glu Asn Ile Glu Asp Tyr Asn Lys Lys Glu Glu Ile Glu 
            900                 905                 910         


Gln Lys Lys Lys Ser Asn Ile Glu Lys Leu Gln Asp Leu Lys Val Glu 
        915                 920                 925             


Leu His Lys Lys Trp Glu Gln Asn Lys Ile Thr Glu Lys Glu Ile Glu 
    930                 935                 940                 


Lys Tyr Asn Asn Thr Thr Arg Lys Ile Asn Glu Tyr Asn Tyr Leu Lys 
945                 950                 955                 960 


Asn Lys Glu Glu Leu Gln Asn Val Tyr Leu Leu His Glu Met Leu Ser 
                965                 970                 975     


Asp Leu Leu Ala Arg Asn Val Ala Phe Phe Asn Lys Trp Glu Arg Asp 
            980                 985                 990         


Phe Lys Phe Ile Val Ile Ala Ile  Lys Gln Phe Leu Arg  Glu Asn Asp 
        995                 1000                 1005             


Lys Glu  Lys Val Asn Glu Phe  Leu Asn Pro Pro Asp  Asn Ser Lys 
    1010                 1015                 1020             


Gly Lys  Lys Val Tyr Phe Ser  Val Ser Lys Tyr Lys  Asn Thr Val 
    1025                 1030                 1035             


Glu Asn  Ile Asp Gly Ile His  Lys Asn Phe Met Asn  Leu Ile Phe 
    1040                 1045                 1050             


Leu Asn  Asn Lys Phe Met Asn  Arg Lys Ile Asp Lys  Met Asn Cys 
    1055                 1060                 1065             


Ala Ile  Trp Val Tyr Phe Arg  Asn Tyr Ile Ala His  Phe Leu His 
    1070                 1075                 1080             


Leu His  Thr Lys Asn Glu Lys  Ile Ser Leu Ile Ser  Gln Met Asn 
    1085                 1090                 1095             


Leu Leu  Ile Lys Leu Phe Ser  Tyr Asp Lys Lys Val  Gln Asn His 
    1100                 1105                 1110             


Ile Leu  Lys Ser Thr Lys Thr  Leu Leu Glu Lys Tyr  Asn Ile Gln 
    1115                 1120                 1125             


Ile Asn  Phe Glu Ile Ser Asn  Asp Lys Asn Glu Val  Phe Lys Tyr 
    1130                 1135                 1140             


Lys Ile  Lys Asn Arg Leu Tyr  Ser Lys Lys Gly Lys  Met Leu Gly 
    1145                 1150                 1155             


Lys Asn  Asn Lys Phe Glu Ile  Leu Glu Asn Glu Phe  Leu Glu Asn 
    1160                 1165                 1170             


Val Lys  Ala Met Leu Glu Tyr  Ser Glu 
    1175                 1180         


<210>  16
<211>  1285
<212>  PRT
<213>  Herbinix hemicellulosilytics

<400>  16

Met Lys Leu Thr Arg Arg Arg Ile Ser Gly Asn Ser Val Asp Gln Lys 
1               5                   10                  15      


Ile Thr Ala Ala Phe Tyr Arg Asp Met Ser Gln Gly Leu Leu Tyr Tyr 
            20                  25                  30          


Asp Ser Glu Asp Asn Asp Cys Thr Asp Lys Val Ile Glu Ser Met Asp 
        35                  40                  45              


Phe Glu Arg Ser Trp Arg Gly Arg Ile Leu Lys Asn Gly Glu Asp Asp 
    50                  55                  60                  


Lys Asn Pro Phe Tyr Met Phe Val Lys Gly Leu Val Gly Ser Asn Asp 
65                  70                  75                  80  


Lys Ile Val Cys Glu Pro Ile Asp Val Asp Ser Asp Pro Asp Asn Leu 
                85                  90                  95      


Asp Ile Leu Ile Asn Lys Asn Leu Thr Gly Phe Gly Arg Asn Leu Lys 
            100                 105                 110         


Ala Pro Asp Ser Asn Asp Thr Leu Glu Asn Leu Ile Arg Lys Ile Gln 
        115                 120                 125             


Ala Gly Ile Pro Glu Glu Glu Val Leu Pro Glu Leu Lys Lys Ile Lys 
    130                 135                 140                 


Glu Met Ile Gln Lys Asp Ile Val Asn Arg Lys Glu Gln Leu Leu Lys 
145                 150                 155                 160 


Ser Ile Lys Asn Asn Arg Ile Pro Phe Ser Leu Glu Gly Ser Lys Leu 
                165                 170                 175     


Val Pro Ser Thr Lys Lys Met Lys Trp Leu Phe Lys Leu Ile Asp Val 
            180                 185                 190         


Pro Asn Lys Thr Phe Asn Glu Lys Met Leu Glu Lys Tyr Trp Glu Ile 
        195                 200                 205             


Tyr Asp Tyr Asp Lys Leu Lys Ala Asn Ile Thr Asn Arg Leu Asp Lys 
    210                 215                 220                 


Thr Asp Lys Lys Ala Arg Ser Ile Ser Arg Ala Val Ser Glu Glu Leu 
225                 230                 235                 240 


Arg Glu Tyr His Lys Asn Leu Arg Thr Asn Tyr Asn Arg Phe Val Ser 
                245                 250                 255     


Gly Asp Arg Pro Ala Ala Gly Leu Asp Asn Gly Gly Ser Ala Lys Tyr 
            260                 265                 270         


Asn Pro Asp Lys Glu Glu Phe Leu Leu Phe Leu Lys Glu Val Glu Gln 
        275                 280                 285             


Tyr Phe Lys Lys Tyr Phe Pro Val Lys Ser Lys His Ser Asn Lys Ser 
    290                 295                 300                 


Lys Asp Lys Ser Leu Val Asp Lys Tyr Lys Asn Tyr Cys Ser Tyr Lys 
305                 310                 315                 320 


Val Val Lys Lys Glu Val Asn Arg Ser Ile Ile Asn Gln Leu Val Ala 
                325                 330                 335     


Gly Leu Ile Gln Gln Gly Lys Leu Leu Tyr Tyr Phe Tyr Tyr Asn Asp 
            340                 345                 350         


Thr Trp Gln Glu Asp Phe Leu Asn Ser Tyr Gly Leu Ser Tyr Ile Gln 
        355                 360                 365             


Val Glu Glu Ala Phe Lys Lys Ser Val Met Thr Ser Leu Ser Trp Gly 
    370                 375                 380                 


Ile Asn Arg Leu Thr Ser Phe Phe Ile Asp Asp Ser Asn Thr Val Lys 
385                 390                 395                 400 


Phe Asp Asp Ile Thr Thr Lys Lys Ala Lys Glu Ala Ile Glu Ser Asn 
                405                 410                 415     


Tyr Phe Asn Lys Leu Arg Thr Cys Ser Arg Met Gln Asp His Phe Lys 
            420                 425                 430         


Glu Lys Leu Ala Phe Phe Tyr Pro Val Tyr Val Lys Asp Lys Lys Asp 
        435                 440                 445             


Arg Pro Asp Asp Asp Ile Glu Asn Leu Ile Val Leu Val Lys Asn Ala 
    450                 455                 460                 


Ile Glu Ser Val Ser Tyr Leu Arg Asn Arg Thr Phe His Phe Lys Glu 
465                 470                 475                 480 


Ser Ser Leu Leu Glu Leu Leu Lys Glu Leu Asp Asp Lys Asn Ser Gly 
                485                 490                 495     


Gln Asn Lys Ile Asp Tyr Ser Val Ala Ala Glu Phe Ile Lys Arg Asp 
            500                 505                 510         


Ile Glu Asn Leu Tyr Asp Val Phe Arg Glu Gln Ile Arg Ser Leu Gly 
        515                 520                 525             


Ile Ala Glu Tyr Tyr Lys Ala Asp Met Ile Ser Asp Cys Phe Lys Thr 
    530                 535                 540                 


Cys Gly Leu Glu Phe Ala Leu Tyr Ser Pro Lys Asn Ser Leu Met Pro 
545                 550                 555                 560 


Ala Phe Lys Asn Val Tyr Lys Arg Gly Ala Asn Leu Asn Lys Ala Tyr 
                565                 570                 575     


Ile Arg Asp Lys Gly Pro Lys Glu Thr Gly Asp Gln Gly Gln Asn Ser 
            580                 585                 590         


Tyr Lys Ala Leu Glu Glu Tyr Arg Glu Leu Thr Trp Tyr Ile Glu Val 
        595                 600                 605             


Lys Asn Asn Asp Gln Ser Tyr Asn Ala Tyr Lys Asn Leu Leu Gln Leu 
    610                 615                 620                 


Ile Tyr Tyr His Ala Phe Leu Pro Glu Val Arg Glu Asn Glu Ala Leu 
625                 630                 635                 640 


Ile Thr Asp Phe Ile Asn Arg Thr Lys Glu Trp Asn Arg Lys Glu Thr 
                645                 650                 655     


Glu Glu Arg Leu Asn Thr Lys Asn Asn Lys Lys His Lys Asn Phe Asp 
            660                 665                 670         


Glu Asn Asp Asp Ile Thr Val Asn Thr Tyr Arg Tyr Glu Ser Ile Pro 
        675                 680                 685             


Asp Tyr Gln Gly Glu Ser Leu Asp Asp Tyr Leu Lys Val Leu Gln Arg 
    690                 695                 700                 


Lys Gln Met Ala Arg Ala Lys Glu Val Asn Glu Lys Glu Glu Gly Asn 
705                 710                 715                 720 


Asn Asn Tyr Ile Gln Phe Ile Arg Asp Val Val Val Trp Ala Phe Gly 
                725                 730                 735     


Ala Tyr Leu Glu Asn Lys Leu Lys Asn Tyr Lys Asn Glu Leu Gln Pro 
            740                 745                 750         


Pro Leu Ser Lys Glu Asn Ile Gly Leu Asn Asp Thr Leu Lys Glu Leu 
        755                 760                 765             


Phe Pro Glu Glu Lys Val Lys Ser Pro Phe Asn Ile Lys Cys Arg Phe 
    770                 775                 780                 


Ser Ile Ser Thr Phe Ile Asp Asn Lys Gly Lys Ser Thr Asp Asn Thr 
785                 790                 795                 800 


Ser Ala Glu Ala Val Lys Thr Asp Gly Lys Glu Asp Glu Lys Asp Lys 
                805                 810                 815     


Lys Asn Ile Lys Arg Lys Asp Leu Leu Cys Phe Tyr Leu Phe Leu Arg 
            820                 825                 830         


Leu Leu Asp Glu Asn Glu Ile Cys Lys Leu Gln His Gln Phe Ile Lys 
        835                 840                 845             


Tyr Arg Cys Ser Leu Lys Glu Arg Arg Phe Pro Gly Asn Arg Thr Lys 
    850                 855                 860                 


Leu Glu Lys Glu Thr Glu Leu Leu Ala Glu Leu Glu Glu Leu Met Glu 
865                 870                 875                 880 


Leu Val Arg Phe Thr Met Pro Ser Ile Pro Glu Ile Ser Ala Lys Ala 
                885                 890                 895     


Glu Ser Gly Tyr Asp Thr Met Ile Lys Lys Tyr Phe Lys Asp Phe Ile 
            900                 905                 910         


Glu Lys Lys Val Phe Lys Asn Pro Lys Thr Ser Asn Leu Tyr Tyr His 
        915                 920                 925             


Ser Asp Ser Lys Thr Pro Val Thr Arg Lys Tyr Met Ala Leu Leu Met 
    930                 935                 940                 


Arg Ser Ala Pro Leu His Leu Tyr Lys Asp Ile Phe Lys Gly Tyr Tyr 
945                 950                 955                 960 


Leu Ile Thr Lys Lys Glu Cys Leu Glu Tyr Ile Lys Leu Ser Asn Ile 
                965                 970                 975     


Ile Lys Asp Tyr Gln Asn Ser Leu Asn Glu Leu His Glu Gln Leu Glu 
            980                 985                 990         


Arg Ile Lys Leu Lys Ser Glu Lys  Gln Asn Gly Lys Asp  Ser Leu Tyr 
        995                 1000                 1005             


Leu Asp  Lys Lys Asp Phe Tyr  Lys Val Lys Glu Tyr  Val Glu Asn 
    1010                 1015                 1020             


Leu Glu  Gln Val Ala Arg Tyr  Lys His Leu Gln His  Lys Ile Asn 
    1025                 1030                 1035             


Phe Glu  Ser Leu Tyr Arg Ile  Phe Arg Ile His Val  Asp Ile Ala 
    1040                 1045                 1050             


Ala Arg  Met Val Gly Tyr Thr  Gln Asp Trp Glu Arg  Asp Met His 
    1055                 1060                 1065             


Phe Leu  Phe Lys Ala Leu Val  Tyr Asn Gly Val Leu  Glu Glu Arg 
    1070                 1075                 1080             


Arg Phe  Glu Ala Ile Phe Asn  Asn Asn Asp Asp Asn  Asn Asp Gly 
    1085                 1090                 1095             


Arg Ile  Val Lys Lys Ile Gln  Asn Asn Leu Asn Asn  Lys Asn Arg 
    1100                 1105                 1110             


Glu Leu  Val Ser Met Leu Cys  Trp Asn Lys Lys Leu  Asn Lys Asn 
    1115                 1120                 1125             


Glu Phe  Gly Ala Ile Ile Trp  Lys Arg Asn Pro Ile  Ala His Leu 
    1130                 1135                 1140             


Asn His  Phe Thr Gln Thr Glu  Gln Asn Ser Lys Ser  Ser Leu Glu 
    1145                 1150                 1155             


Ser Leu  Ile Asn Ser Leu Arg  Ile Leu Leu Ala Tyr  Asp Arg Lys 
    1160                 1165                 1170             


Arg Gln  Asn Ala Val Thr Lys  Thr Ile Asn Asp Leu  Leu Leu Asn 
    1175                 1180                 1185             


Asp Tyr  His Ile Arg Ile Lys  Trp Glu Gly Arg Val  Asp Glu Gly 
    1190                 1195                 1200             


Gln Ile  Tyr Phe Asn Ile Lys  Glu Lys Glu Asp Ile  Glu Asn Glu 
    1205                 1210                 1215             


Pro Ile  Ile His Leu Lys His  Leu His Lys Lys Asp  Cys Tyr Ile 
    1220                 1225                 1230             


Tyr Lys  Asn Ser Tyr Met Phe  Asp Lys Gln Lys Glu  Trp Ile Cys 
    1235                 1240                 1245             


Asn Gly  Ile Lys Glu Glu Val  Tyr Asp Lys Ser Ile  Leu Lys Cys 
    1250                 1255                 1260             


Ile Gly  Asn Leu Phe Lys Phe  Asp Tyr Glu Asp Lys  Asn Lys Ser 
    1265                 1270                 1275             


Ser Ala  Asn Pro Lys His Thr  
    1280                 1285 


<210>  17
<211>  966
<212>  PRT
<213>  Ruminococcus flavefaciens

<400>  17

Met Ile Glu Lys Lys Lys Ser Phe Ala Lys Gly Met Gly Val Lys Ser 
1               5                   10                  15      


Thr Leu Val Ser Gly Ser Lys Val Tyr Met Thr Thr Phe Ala Glu Gly 
            20                  25                  30          


Ser Asp Ala Arg Leu Glu Lys Ile Val Glu Gly Asp Ser Ile Arg Ser 
        35                  40                  45              


Val Asn Glu Gly Glu Ala Phe Ser Ala Glu Met Ala Asp Lys Asn Ala 
    50                  55                  60                  


Gly Tyr Lys Ile Gly Asn Ala Lys Phe Ser His Pro Lys Gly Tyr Ala 
65                  70                  75                  80  


Val Val Ala Asn Asn Pro Leu Tyr Thr Gly Pro Val Gln Gln Asp Met 
                85                  90                  95      


Leu Gly Leu Lys Glu Thr Leu Glu Lys Arg Tyr Phe Gly Glu Ser Ala 
            100                 105                 110         


Asp Gly Asn Asp Asn Ile Cys Ile Gln Val Ile His Asn Ile Leu Asp 
        115                 120                 125             


Ile Glu Lys Ile Leu Ala Glu Tyr Ile Thr Asn Ala Ala Tyr Ala Val 
    130                 135                 140                 


Asn Asn Ile Ser Gly Leu Asp Lys Asp Ile Ile Gly Phe Gly Lys Phe 
145                 150                 155                 160 


Ser Thr Val Tyr Thr Tyr Asp Glu Phe Lys Asp Pro Glu His His Arg 
                165                 170                 175     


Ala Ala Phe Asn Asn Asn Asp Lys Leu Ile Asn Ala Ile Lys Ala Gln 
            180                 185                 190         


Tyr Asp Glu Phe Asp Asn Phe Leu Asp Asn Pro Arg Leu Gly Tyr Phe 
        195                 200                 205             


Gly Gln Ala Phe Phe Ser Lys Glu Gly Arg Asn Tyr Ile Ile Asn Tyr 
    210                 215                 220                 


Gly Asn Glu Cys Tyr Asp Ile Leu Ala Leu Leu Ser Gly Leu Arg His 
225                 230                 235                 240 


Trp Val Val His Asn Asn Glu Glu Glu Ser Arg Ile Ser Arg Thr Trp 
                245                 250                 255     


Leu Tyr Asn Leu Asp Lys Asn Leu Asp Asn Glu Tyr Ile Ser Thr Leu 
            260                 265                 270         


Asn Tyr Leu Tyr Asp Arg Ile Thr Asn Glu Leu Thr Asn Ser Phe Ser 
        275                 280                 285             


Lys Asn Ser Ala Ala Asn Val Asn Tyr Ile Ala Glu Thr Leu Gly Ile 
    290                 295                 300                 


Asn Pro Ala Glu Phe Ala Glu Gln Tyr Phe Arg Phe Ser Ile Met Lys 
305                 310                 315                 320 


Glu Gln Lys Asn Leu Gly Phe Asn Ile Thr Lys Leu Arg Glu Val Met 
                325                 330                 335     


Leu Asp Arg Lys Asp Met Ser Glu Ile Arg Lys Asn His Lys Val Phe 
            340                 345                 350         


Asp Ser Ile Arg Thr Lys Val Tyr Thr Met Met Asp Phe Val Ile Tyr 
        355                 360                 365             


Arg Tyr Tyr Ile Glu Glu Asp Ala Lys Val Ala Ala Ala Asn Lys Ser 
    370                 375                 380                 


Leu Pro Asp Asn Glu Lys Ser Leu Ser Glu Lys Asp Ile Phe Val Ile 
385                 390                 395                 400 


Asn Leu Arg Gly Ser Phe Asn Asp Asp Gln Lys Asp Ala Leu Tyr Tyr 
                405                 410                 415     


Asp Glu Ala Asn Arg Ile Trp Arg Lys Leu Glu Asn Ile Met His Asn 
            420                 425                 430         


Ile Lys Glu Phe Arg Gly Asn Lys Thr Arg Glu Tyr Lys Lys Lys Asp 
        435                 440                 445             


Ala Pro Arg Leu Pro Arg Ile Leu Pro Ala Gly Arg Asp Val Ser Ala 
    450                 455                 460                 


Phe Ser Lys Leu Met Tyr Ala Leu Thr Met Phe Leu Asp Gly Lys Glu 
465                 470                 475                 480 


Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Gln 
                485                 490                 495     


Ser Phe Leu Lys Val Met Pro Leu Ile Gly Val Asn Ala Lys Phe Val 
            500                 505                 510         


Glu Glu Tyr Ala Phe Phe Lys Asp Ser Ala Lys Ile Ala Asp Glu Leu 
        515                 520                 525             


Arg Leu Ile Lys Ser Phe Ala Arg Met Gly Glu Pro Ile Ala Asp Ala 
    530                 535                 540                 


Arg Arg Ala Met Tyr Ile Asp Ala Ile Arg Ile Leu Gly Thr Asn Leu 
545                 550                 555                 560 


Ser Tyr Asp Glu Leu Lys Ala Leu Ala Asp Thr Phe Ser Leu Asp Glu 
                565                 570                 575     


Asn Gly Asn Lys Leu Lys Lys Gly Lys His Gly Met Arg Asn Phe Ile 
            580                 585                 590         


Ile Asn Asn Val Ile Ser Asn Lys Arg Phe His Tyr Leu Ile Arg Tyr 
        595                 600                 605             


Gly Asp Pro Ala His Leu His Glu Ile Ala Lys Asn Glu Ala Val Val 
    610                 615                 620                 


Lys Phe Val Leu Gly Arg Ile Ala Asp Ile Gln Lys Lys Gln Gly Gln 
625                 630                 635                 640 


Asn Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys Ile Gly Lys 
                645                 650                 655     


Asp Lys Gly Lys Ser Val Ser Glu Lys Val Asp Ala Leu Thr Lys Ile 
            660                 665                 670         


Ile Thr Gly Met Asn Tyr Asp Gln Phe Asp Lys Lys Arg Ser Val Ile 
        675                 680                 685             


Glu Asp Thr Gly Arg Glu Asn Ala Glu Arg Glu Lys Phe Lys Lys Ile 
    690                 695                 700                 


Ile Ser Leu Tyr Leu Thr Val Ile Tyr His Ile Leu Lys Asn Ile Val 
705                 710                 715                 720 


Asn Ile Asn Ala Arg Tyr Val Ile Gly Phe His Cys Val Glu Arg Asp 
                725                 730                 735     


Ala Gln Leu Tyr Lys Glu Lys Gly Tyr Asp Ile Asn Leu Lys Lys Leu 
            740                 745                 750         


Glu Glu Lys Gly Phe Ser Ser Val Thr Lys Leu Cys Ala Gly Ile Asp 
        755                 760                 765             


Glu Thr Ala Pro Asp Lys Arg Lys Asp Val Glu Lys Glu Met Ala Glu 
    770                 775                 780                 


Arg Ala Lys Glu Ser Ile Asp Ser Leu Glu Ser Ala Asn Pro Lys Leu 
785                 790                 795                 800 


Tyr Ala Asn Tyr Ile Lys Tyr Ser Asp Glu Lys Lys Ala Glu Glu Phe 
                805                 810                 815     


Thr Arg Gln Ile Asn Arg Glu Lys Ala Lys Thr Ala Leu Asn Ala Tyr 
            820                 825                 830         


Leu Arg Asn Thr Lys Trp Asn Val Ile Ile Arg Glu Asp Leu Leu Arg 
        835                 840                 845             


Ile Asp Asn Lys Thr Cys Thr Leu Phe Arg Asn Lys Ala Val His Leu 
    850                 855                 860                 


Glu Val Ala Arg Tyr Val His Ala Tyr Ile Asn Asp Ile Ala Glu Val 
865                 870                 875                 880 


Asn Ser Tyr Phe Gln Leu Tyr His Tyr Ile Met Gln Arg Ile Ile Met 
                885                 890                 895     


Asn Glu Arg Tyr Glu Lys Ser Ser Gly Lys Val Ser Glu Tyr Phe Asp 
            900                 905                 910         


Ala Val Asn Asp Glu Lys Lys Tyr Asn Asp Arg Leu Leu Lys Leu Leu 
        915                 920                 925             


Cys Val Pro Phe Gly Tyr Cys Ile Pro Arg Phe Lys Asn Leu Ser Ile 
    930                 935                 940                 


Glu Ala Leu Phe Asp Arg Asn Glu Ala Ala Lys Phe Asp Lys Glu Lys 
945                 950                 955                 960 


Lys Lys Val Ser Gly Asn 
                965     


<210>  18
<211>  2901
<212>  DNA
<213>  Ruminococcus flavefaciens

<400>  18
atgatcgaaa aaaaaaagtc cttcgccaag ggcatgggcg tgaagtccac actcgtgtcc       60

ggctccaaag tgtacatgac aaccttcgcc gaaggcagcg acgccaggct ggaaaagatc      120

gtggagggcg acagcatcag gagcgtgaat gagggcgagg ccttcagcgc tgaaatggcc      180

gataaaaacg ccggctataa gatcggcaac gccaaattca gccatcctaa gggctacgcc      240

gtggtggcta acaaccctct gtatacagga cccgtccagc aggatatgct cggcctgaag      300

gaaactctgg aaaagaggta cttcggcgag agcgctgatg gcaatgacaa tatttgtatc      360

caggtgatcc ataacatcct ggacattgaa aaaatcctcg ccgaatacat taccaacgcc      420

gcctacgccg tcaacaatat ctccggcctg gataaggaca ttattggatt cggcaagttc      480

tccacagtgt atacctacga cgaattcaaa gaccccgagc accatagggc cgctttcaac      540

aataacgata agctcatcaa cgccatcaag gcccagtatg acgagttcga caacttcctc      600

gataacccca gactcggcta tttcggccag gcctttttca gcaaggaggg cagaaattac      660

atcatcaatt acggcaacga atgctatgac attctggccc tcctgagcgg actgaggcac      720

tgggtggtcc ataacaacga agaagagtcc aggatctcca ggacctggct ctacaacctc      780

gataagaacc tcgacaacga atacatctcc accctcaact acctctacga caggatcacc      840

aatgagctga ccaactcctt ctccaagaac tccgccgcca acgtgaacta tattgccgaa      900

actctgggaa tcaaccctgc cgaattcgcc gaacaatatt tcagattcag cattatgaaa      960

gagcagaaaa acctcggatt caatatcacc aagctcaggg aagtgatgct ggacaggaag     1020

gatatgtccg agatcaggaa aaatcataag gtgttcgact ccatcaggac caaggtctac     1080

accatgatgg actttgtgat ttataggtat tacatcgaag aggatgccaa ggtggctgcc     1140

gccaataagt ccctccccga taatgagaag tccctgagcg agaaggatat ctttgtgatt     1200

aacctgaggg gctccttcaa cgacgaccag aaggatgccc tctactacga tgaagctaat     1260

agaatttgga gaaagctcga aaatatcatg cacaacatca aggaatttag gggaaacaag     1320

acaagagagt ataagaagaa ggacgcccct agactgccca gaatcctgcc cgctggccgt     1380

gatgtttccg ccttcagcaa actcatgtat gccctgacca tgttcctgga tggcaaggag     1440

atcaacgacc tcctgaccac cctgattaat aaattcgata acatccagag cttcctgaag     1500

gtgatgcctc tcatcggagt caacgctaag ttcgtggagg aatacgcctt tttcaaagac     1560

tccgccaaga tcgccgatga gctgaggctg atcaagtcct tcgctagaat gggagaacct     1620

attgccgatg ccaggagggc catgtatatc gacgccatcc gtattttagg aaccaacctg     1680

tcctatgatg agctcaaggc cctcgccgac accttttccc tggacgagaa cggaaacaag     1740

ctcaagaaag gcaagcacgg catgagaaat ttcattatta ataacgtgat cagcaataaa     1800

aggttccact acctgatcag atacggtgat cctgcccacc tccatgagat cgccaaaaac     1860

gaggccgtgg tgaagttcgt gctcggcagg atcgctgaca tccagaaaaa acagggccag     1920

aacggcaaga accagatcga caggtactac gaaacttgta tcggaaagga taagggcaag     1980

agcgtgagcg aaaaggtgga cgctctcaca aagatcatca ccggaatgaa ctacgaccaa     2040

ttcgacaaga aaaggagcgt cattgaggac accggcaggg aaaacgccga gagggagaag     2100

tttaaaaaga tcatcagcct gtacctcacc gtgatctacc acatcctcaa gaatattgtc     2160

aatatcaacg ccaggtacgt catcggattc cattgcgtcg agcgtgatgc tcaactgtac     2220

aaggagaaag gctacgacat caatctcaag aaactggaag agaagggatt cagctccgtc     2280

accaagctct gcgctggcat tgatgaaact gcccccgata agagaaagga cgtggaaaag     2340

gagatggctg aaagagccaa ggagagcatt gacagcctcg agagcgccaa ccccaagctg     2400

tatgccaatt acatcaaata cagcgacgag aagaaagccg aggagttcac caggcagatt     2460

aacagggaga aggccaaaac cgccctgaac gcctacctga ggaacaccaa gtggaatgtg     2520

atcatcaggg aggacctcct gagaattgac aacaagacat gtaccctgtt cagaaacaag     2580

gccgtccacc tggaagtggc caggtatgtc cacgcctata tcaacgacat tgccgaggtc     2640

aattcctact tccaactgta ccattacatc atgcagagaa ttatcatgaa tgagaggtac     2700

gagaaaagca gcggaaaggt gtccgagtac ttcgacgctg tgaatgacga gaagaagtac     2760

aacgataggc tcctgaaact gctgtgtgtg cctttcggct actgtatccc caggtttaag     2820

aacctgagca tcgaggccct gttcgatagg aacgaggccg ccaagttcga caaggagaaa     2880

aagaaggtgt ccggcaatta a                                               2901


