                         SEQUENCE LISTING

<110>  University of Miami
 
<120>  METHOD FOR TREATING SARCOIDOSIS

<130>  32286/54402A/PC

<150>  US 62/875,703
<151>  2019-07-18

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  hGHRH (1-29)HN2

<400>  1

Tyr Ala Asp Ala Ile Phe Thr Asn Ser Tyr Arg Lys Val Leu Gly Gln 
1               5                   10                  15      


Leu Ser Ala Arg Lys Leu Leu Gln Asp Ile Met Ser Arg 
            20                  25                  


<210>  2
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is PhAc (phenylacetyl), Nac (naphthylacetyl), Oct (octanoyl),
       N-Me-Aib (N-methyl-alpha-aminoisobutyroyl), Dca (dichloroacetyl),
       Ac-Ada (acetyl-12-aminododecanoyl), Fer (ferulyl), Ac-Amc 
       (acetyl-8-aminocaprylyl), Me-NH-Sub (methyl-NH-suberyl),

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Ala or Me-Ala

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Cpa (para-chlorophenylalanine) or Phe(F)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Ala, Pal (pyridylalanine), Dip ((3,3-diphenyl)alanine), or
       Me-Ala

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Har

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is FPa5, Tyr(Alk) where Alk is Me or Et

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is His or Arg

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Lys, Lys(0-11) (Lys(A0-A1-A2-A3-A4-A5-A6-A7-A8-A9 
       A10-A11-), Lys(Me)2, or Orn (ornithine)

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Abu (alpha-aminobutyric acid) or Orn

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Leu or Glu

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Har (homoarginine) or His

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Lys, Lys(Me)2 or Orn

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Har, Arg or Agm (agmatine)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is  Ala, Amc, Apa, Ada, AE2A , AE4P,E -Lys( alpha-NH2), Agm, 
       or absent

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa is  Lys(Oct), Ahx (6-aminohexanoyl), or absent

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  AMIDATION

<400>  2

Xaa Tyr Xaa Asp Xaa Ile Xaa Thr Xaa Xaa Xaa Xaa Xaa Val Leu Xaa 
1               5                   10                  15      


Gln Xaa Ser Ala Xaa Xaa Leu Leu Gln Asp Ile Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


<210>  3
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phac

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ada

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Phe(F)5

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Har

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Tyr(Me)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Orn

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Abu

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Orn

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Har

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa is Agm

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  AMIDATION

<400>  3

Xaa Xaa Tyr Xaa Asp Ala Ile Xaa Thr Ala Xaa Xaa His Xaa Val Leu 
1               5                   10                  15      


Xaa Gln Leu Ser Ala His Xaa Leu Leu Gln Asp Ile Xaa Xaa Xaa Xaa 
            20                  25                  30          


<210>  4
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phac

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ada

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Phe(F)5

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Thr(Me)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Har

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Tyr(Me)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Orn

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Abu

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Orn

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Har

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa is Agm

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  AMIDATION

<400>  4

Xaa Xaa Tyr Xaa Asp Ala Ile Xaa Xaa Ala Xaa Xaa His Xaa Val Leu 
1               5                   10                  15      


Xaa Gln Leu Ser Ala His Xaa Leu Leu Gln Asp Ile Xaa Xaa Xaa Xaa 
            20                  25                  30          


<210>  5
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phac

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Cpa

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Har

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Fpa

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Orn

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Abu

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Orn

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Har

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Ada

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  AMIDATION

<400>  5

Xaa Tyr Xaa Asp Ala Ile Xaa Thr Ala Xaa Xaa His Xaa Val Leu Xaa 
1               5                   10                  15      


Gln Leu Ser Ala His Xaa Leu Leu Gly Ala Ile Xaa Xaa Xaa Xaa 
            20                  25                  30      


<210>  6
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phac

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ada

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Cpa

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Har

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Fpa

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Orn

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Abu

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Orn

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Har

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa is Ada

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  C-Term NH2

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  AMIDATION

<400>  6

Xaa Xaa Tyr Xaa Asp Ala Ile Xaa Thr Ala Xaa Xaa His Xaa Val Leu 
1               5                   10                  15      


Xaa Gln Gln Ser Ala His Xaa Leu Leu Gln Asp Ile Xaa Xaa Xaa Xaa 
            20                  25                  30          


<210>  7
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phac

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ada

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Cpa

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Har

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Fpa

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Orn

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Abu

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Orn

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Har

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  AMIDATION

<400>  7

Xaa Xaa Tyr Xaa Asp Ala Ile Xaa Thr Ala Xaa Xaa His Xaa Val Leu 
1               5                   10                  15      


Xaa Gln Leu Ser Ala His Xaa Leu Leu Gln Asp Ile Xaa Xaa Xaa 
            20                  25                  30      


<210>  8
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is PhAc

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Ada

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is D-ARg

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Fpa

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Har

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Tyr(Me)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Orn

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Abu

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Orn

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is D-Arg

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Har

<400>  8

Xaa Xaa Tyr Xaa Asp Ala Ile Xaa Thr Ala Xaa Xaa His Xaa Val Leu 
1               5                   10                  15      


Xaa Gln Leu Ser Ala Xaa Lys Leu Leu Gln Asp Ile Xaa Xaa Xaa 
            20                  25                  30      


