                         SEQUENCE LISTING 
 
<110>  BRISTOL-MYERS SQUIBB COMPANY 
  
<120>  ANTIBODIES AGAINST HUMAN TREM-1 AND USES THEREOF 
 
<130>  3338.0960000/ELE/C-K/DKC 
 
<140>  US 62/874,316 
<141>  2019-07-15 
 
<160>  340    
<170>  PatentIn version 3.5 
 
<210>  1 
<211>  234 
<212>  PRT 
<213>  Homo Sapien 
 
<400>  1 
 
Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser  
1               5                   10                  15       
 
 
Glu Leu Arg Ala Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys  
            20                  25                  30           
 
 
Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe  
        35                  40                  45               
 
 
Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro  
    50                  55                  60                   
 
 
Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val  
65                  70                  75                  80   
 
 
Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu  
                85                  90                  95       
 
 
Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln  
            100                 105                 110          
 
 
Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg  
        115                 120                 125              
 
 
Ile Arg Leu Val Val Thr Lys Gly Phe Ser Gly Thr Pro Gly Ser Asn  
    130                 135                 140                  
 
 
Glu Asn Ser Thr Gln Asn Val Tyr Lys Ile Pro Pro Thr Thr Thr Lys  
145                 150                 155                 160  
 
 
Ala Leu Cys Pro Leu Tyr Thr Ser Pro Arg Thr Val Thr Gln Ala Pro  
                165                 170                 175      
 
 
Pro Lys Ser Thr Ala Asp Val Ser Thr Pro Asp Ser Glu Ile Asn Leu  
            180                 185                 190          
 
 
Thr Asn Val Thr Asp Ile Ile Arg Val Pro Val Phe Asn Ile Val Ile  
        195                 200                 205              
 
 
Leu Leu Ala Gly Gly Phe Leu Ser Lys Ser Leu Val Phe Ser Val Leu  
    210                 215                 220                  
 
 
Phe Ala Val Thr Leu Arg Ser Phe Val Pro  
225                 230                  
 
 
<210>  2 
<211>  225 
<212>  PRT 
<213>  Homo Sapien 
 
<400>  2 
 
Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser  
1               5                   10                  15       
 
 
Glu Leu Arg Ala Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys  
            20                  25                  30           
 
 
Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe  
        35                  40                  45               
 
 
Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro  
    50                  55                  60                   
 
 
Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val  
65                  70                  75                  80   
 
 
Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu  
                85                  90                  95       
 
 
Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln  
            100                 105                 110          
 
 
Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg  
        115                 120                 125              
 
 
Ile Arg Leu Val Val Thr Lys Gly Phe Ser Gly Thr Pro Gly Ser Asn  
    130                 135                 140                  
 
 
Glu Asn Ser Thr Gln Asn Val Tyr Lys Ile Pro Pro Thr Thr Thr Lys  
145                 150                 155                 160  
 
 
Ala Leu Cys Pro Leu Tyr Thr Ser Pro Arg Thr Val Thr Gln Ala Pro  
                165                 170                 175      
 
 
Pro Lys Ser Thr Ala Asp Val Ser Thr Pro Asp Ser Glu Ile Asn Leu  
            180                 185                 190          
 
 
Thr Asn Val Thr Asp Ile Ile Arg Tyr Ser Phe Gln Val Pro Gly Pro  
        195                 200                 205              
 
 
Leu Val Trp Thr Leu Ser Pro Leu Phe Pro Ser Leu Cys Ala Glu Arg  
    210                 215                 220                  
 
 
Met  
225  
 
 
<210>  3 
<211>  150 
<212>  PRT 
<213>  Homo Sapien 
 
<400>  3 
 
Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser  
1               5                   10                  15       
 
 
Glu Leu Arg Ala Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys  
            20                  25                  30           
 
 
Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe  
        35                  40                  45               
 
 
Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro  
    50                  55                  60                   
 
 
Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val  
65                  70                  75                  80   
 
 
Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu  
                85                  90                  95       
 
 
Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln  
            100                 105                 110          
 
 
Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg  
        115                 120                 125              
 
 
Ile Arg Leu Val Val Thr Lys Gly Phe Arg Cys Ser Thr Leu Ser Phe  
    130                 135                 140                  
 
 
Ser Trp Leu Val Asp Ser  
145                 150  
 
 
<210>  4 
<211>  3333 
<212>  DNA 
<213>  Homo Sapien 
 
<400>  4 
gtgcaacttt ccgaagcctc taggtcattg tggtgccttg tagctgtccc gggagccctc       60 
 
agcagcagtt ggagctggtg cacaggaagg atgaggaaga ccaggctctg ggggctgctg      120 
 
tggatgctct ttgtctcaga actccgagct gcaactaaat taactgagga aaagtatgaa      180 
 
ctgaaagagg ggcagaccct ggatgtgaaa tgtgactaca cgctagagaa gtttgccagc      240 
 
agccagaaag cttggcagat aataagggac ggagagatgc ccaagaccct ggcatgcaca      300 
 
gagaggcctt caaagaattc ccatccagtc caagtgggga ggatcatact agaagactac      360 
 
catgatcatg gtttactgcg cgtccgaatg gtcaaccttc aagtggaaga ttctggactg      420 
 
tatcagtgtg tgatctacca gcctcccaag gagcctcaca tgctgttcga tcgcatccgc      480 
 
ttggtggtga ccaagggttt ttcagggacc cctggctcca atgagaattc tacccagaat      540 
 
gtgtataaga ttcctcctac caccactaag gccttgtgcc cactctatac cagccccaga      600 
 
actgtgaccc aagctccacc caagtcaact gccgatgtct ccactcctga ctctgaaatc      660 
 
aaccttacaa atgtgacaga tatcatcagg gttccggtgt tcaacattgt cattctcctg      720 
 
gctggtggat tcctgagtaa gagcctggtc ttctctgtcc tgtttgctgt cacgctgagg      780 
 
tcatttgtac cctaggccca cgaacccacg agaatgtcct ctgacttcca gccacatcca      840 
 
tctggcagtt gtgccaaggg aggagggagg aggtaaaagg cagggagtta ataacatgaa      900 
 
ttaaatctgt aatcaccggc tatttctaaa gtcagcgtct caccttcctg cccactgccc      960 
 
tcgttcctct aataatcttg ggtgggcatt tgtgcctcag aaaagaagtt acagccccaa     1020 
 
acatgcttgg tccttcattc caccagccac ttggggttgg catgaaatac agacagctca     1080 
 
atgcttttca ccgtaattct cttgtggggg ctgtgacatg cagaaggcac acctgatact     1140 
 
tctcctgctc agttttgccc tggaccatac aattttggcc tgacctggac agagctccca     1200 
 
ctacagaagc atcctgctcg ccccatgctg ggacttcctc tttctagcat cagacacttg     1260 
 
ggtttcatgc ttatgtgtgg ttctttccaa cactcccaga aaagggtgtt gaagattgtg     1320 
 
gaacctggag aaataagaca tcgtggtgag aaagtgcatc cttctcagag aaaagagtta     1380 
 
aactgagtat cttcttctgg ggaaatactg gcaggccgag atgggatcca taggagagca     1440 
 
acaacagacc atgtcagaca tcctgtgtgc atttatcgct ggatcctgaa aatagccccg     1500 
 
tgaaggcaga aatgtatgtg actagaacga ggccacatga ataagccact gcccactggc     1560 
 
aggagtgaaa actgaagcgc tccttacctg aaggacccca aaaccatata gaatagaata     1620 
 
accaggagtt ccgcctgtgt ctaaatgcct cttttcctgt atcacacaag ggtcagggat     1680 
 
ggtggagtaa aagctctccc cctgggaggc ttctggaggc tgtccccatg tgcttgccta     1740 
 
gttccccact ctgccctcct cctcttctct cagtctgctc ctggaacacc tgcctcagtt     1800 
 
tccatgctct ctccagtgcc ctccccggtg aagcaggtag gtgttcaggc caccacagag     1860 
 
acaatctctg tgggagattg tcttgcaatc tcccacagat ttcaatcagg attttgttat     1920 
 
ttcctacttt gagctttaaa gggaaatggg cctcatgggt ggggaaagga tggtgggtcc     1980 
 
ttccagccca atttagtgat gcccagggca gatattatcc tcagttccca agagcaatca     2040 
 
tacttttcca cacataccgt gtgtctcatg ttaggtaaat gtatttttac aatgagcacc     2100 
 
acttctgtgg aaaaagttcc ctgcacgggg aggtccagct tccagactgc tccatcgcat     2160 
 
aaggacttcc ccattcccct aaatgctgct ctgtcagaac ctgcccaggt aatggtaatg     2220 
 
accctagaga gatgatttct gaaccgcaat tttgagccca ttagaaggtg tgtggtgggc     2280 
 
atttatttca tcctgatgct ctggtgagaa tctttgcaga cgcactagat ccagaagctg     2340 
 
ttaatcttgg tgcatttatt ttcctaccta aaagaaccaa gcagctcaga ggcagtgact     2400 
 
gtacaggatg cagtgtttat aataatgctg agcttgctgg tctggaaccc cacactttag     2460 
 
caatcccagc attgttcctg tttatgaagt tgacaaagtg accagggcaa gggggtatta     2520 
 
tcattaaata cactctagga gaggcagaac acatgagggc aatgtttttc agaggtcttt     2580 
 
aggccaccgc atcagattct cctggagcat aaagcaaatg ctttatgagt ccagggcccc     2640 
 
tgcagaccta ctgtatacta gtatacagct ccctcttagt ggatctcaag cttgtttcca     2700 
 
aaaagtcatt acactcctta ccaaagccca tgacacattc atacagattc atccagacat     2760 
 
aacccactgc atggtccagt gcatgcttgt gtgcttaact tattatagat caagtgttat     2820 
 
ttaagtccaa catattaaac gtgactgaaa tattatatgc actaaatcgg aagacaaatg     2880 
 
gccgtgctgg atactctccc atttgcactt acaggccacg ccatgctcca tcctccccat     2940 
 
cctgcctggg aacctgacca atgtggctaa accagcaggc tccctggctg ccagcttctg     3000 
 
gctggttgag ccaatgggaa gcatgagagg agagccgagg gtggggagac agtcagatca     3060 
 
gggtttctgt cctcagggct ccctccctgg caggtggtgg caggagtggc tgcattcccc     3120 
 
tctgaaggct ccttcaagcc tctcagcaaa cagctcccat ctccaagtcc agccacctgt     3180 
 
tccatcctct cctctgtagg cccagcagtg ggaatgaccc accactattg ccagcctcag     3240 
 
catactgaag caccccttac tggattccct aaattctatg cacatgttta ttaaatgctc     3300 
 
ctcaattacc cagttaaaaa aaaaaaaaaa aaa                                  3333 
 
 
<210>  5 
<211>  2128 
<212>  DNA 
<213>  Homo Sapien 
 
<400>  5 
gtgcaacttt ccgaagcctc taggtcattg tggtgccttg tagctgtccc gggagccctc       60 
 
agcagcagtt ggagctggtg cacaggaagg atgaggaaga ccaggctctg ggggctgctg      120 
 
tggatgctct ttgtctcaga actccgagct gcaactaaat taactgagga aaagtatgaa      180 
 
ctgaaagagg ggcagaccct ggatgtgaaa tgtgactaca cgctagagaa gtttgccagc      240 
 
agccagaaag cttggcagat aataagggac ggagagatgc ccaagaccct ggcatgcaca      300 
 
gagaggcctt caaagaattc ccatccagtc caagtgggga ggatcatact agaagactac      360 
 
catgatcatg gtttactgcg cgtccgaatg gtcaaccttc aagtggaaga ttctggactg      420 
 
tatcagtgtg tgatctacca gcctcccaag gagcctcaca tgctgttcga tcgcatccgc      480 
 
ttggtggtga ccaagggttt ttcagggacc cctggctcca atgagaattc tacccagaat      540 
 
gtgtataaga ttcctcctac caccactaag gccttgtgcc cactctatac cagccccaga      600 
 
actgtgaccc aagctccacc caagtcaact gccgatgtct ccactcctga ctctgaaatc      660 
 
aaccttacaa atgtgacaga tatcatcagg tatagtttcc aggtccctgg gcccctggtt      720 
 
tggacactga gccctttgtt tcccagtctg tgtgctgaga ggatgtgaaa gtgagggaaa      780 
 
ggggagggtg gggcaggaga agacttgagt cacattagtc tgggtagaaa tgtccagggg      840 
 
aagaaggaag tggtgatgga gaatagggga ggctctcagc caggctgtcc ttctccccag      900 
 
ttcaccttct ttgtttcctt gcaacctgag tattaaagag agggaaatgg catcttcccc      960 
 
aagttccagt ggagctcatc caaccccagg ggcctgatgg gcagtgggaa agcactctga     1020 
 
gtgaggggcc ctggatctag tgttggcctg actaactgaa tgtgactttg ggtgagtcag     1080 
 
gaaccctctc tggctttagc ttctttgaca attcagtagg catggtagaa acccaaagct     1140 
 
ggaagacatt gtccacctaa taactctcag caggagctgg agctggggct aaatgcagta     1200 
 
ttggtttttg ccttattgtt ttttaaataa cattgttgca tgtgcccaat tatagataaa     1260 
 
tagaatcaga atttttgcag atgaggtccc tctcagtatt tttaataaga tgtttaggag     1320 
 
atttctaatg tgtaggcaaa cttaagaacc actaacttag caatttcaca cctctttaca     1380 
 
gttattaaat gttgatttat attagaatgt gtttatcatt aaatactgaa ttatcaggat     1440 
 
ggaaatactt ttccacatca ccactagtct aacatgtctt ttttctcata ttctcttcta     1500 
 
gtctttattc atgtttatac atattttaat atggcagtaa gtctaattat acatgttttt     1560 
 
attcttttcc ttgctgaaat tattctttga tgctgctacc taaatttcat aaatataatt     1620 
 
tcaatgagtg catatttttc tatcaattgg gaaagccata acttacataa ccattggcct     1680 
 
gttcttagac attgatatag tgttgataac tctgagataa acatattctt gcagatatat     1740 
 
ttttcttctt ttaaataatt aactcgaaat ttccatgaga taatttaaac actgatatca     1800 
 
ttttgtatac aaatagcatc taccaatggt cttccaaaag attggaaaca atttgcagtg     1860 
 
tgatccatta agcataaata aagcagtgtc atggcaggct tacagacacg gatttagtct     1920 
 
tttaaatcat taaatagtgt gagttaaatc acattcctgc taaaacaaat gtgaactggt     1980 
 
gcctgctcta atttctctat gagtgtagac tccacctcca tatgggtagt ggcagtgcct     2040 
 
ttttccccat tatgttgttt ggggaacaaa gtgctcatta aacttctgtg gaataaatca     2100 
 
aacgaatgat caaaaaaaaa aaaaaaaa                                        2128 
 
 
<210>  6 
<211>  3140 
<212>  DNA 
<213>  Homo Sapien 
 
<400>  6 
gtgcaacttt ccgaagcctc taggtcattg tggtgccttg tagctgtccc gggagccctc       60 
 
agcagcagtt ggagctggtg cacaggaagg atgaggaaga ccaggctctg ggggctgctg      120 
 
tggatgctct ttgtctcaga actccgagct gcaactaaat taactgagga aaagtatgaa      180 
 
ctgaaagagg ggcagaccct ggatgtgaaa tgtgactaca cgctagagaa gtttgccagc      240 
 
agccagaaag cttggcagat aataagggac ggagagatgc ccaagaccct ggcatgcaca      300 
 
gagaggcctt caaagaattc ccatccagtc caagtgggga ggatcatact agaagactac      360 
 
catgatcatg gtttactgcg cgtccgaatg gtcaaccttc aagtggaaga ttctggactg      420 
 
tatcagtgtg tgatctacca gcctcccaag gagcctcaca tgctgttcga tcgcatccgc      480 
 
ttggtggtga ccaaggggtt ccggtgttca acattgtcat tctcctggct ggtggattcc      540 
 
tgagtaagag cctggtcttc tctgtcctgt ttgctgtcac gctgaggtca tttgtaccct      600 
 
aggcccacga acccacgaga atgtcctctg acttccagcc acatccatct ggcagttgtg      660 
 
ccaagggagg agggaggagg taaaaggcag ggagttaata acatgaatta aatctgtaat      720 
 
caccggctat ttctaaagtc agcgtctcac cttcctgccc actgccctcg ttcctctaat      780 
 
aatcttgggt gggcatttgt gcctcagaaa agaagttaca gccccaaaca tgcttggtcc      840 
 
ttcattccac cagccacttg gggttggcat gaaatacaga cagctcaatg cttttcaccg      900 
 
taattctctt gtgggggctg tgacatgcag aaggcacacc tgatacttct cctgctcagt      960 
 
tttgccctgg accatacaat tttggcctga cctggacaga gctcccacta cagaagcatc     1020 
 
ctgctcgccc catgctggga cttcctcttt ctagcatcag acacttgggt ttcatgctta     1080 
 
tgtgtggttc tttccaacac tcccagaaaa gggtgttgaa gattgtggaa cctggagaaa     1140 
 
taagacatcg tggtgagaaa gtgcatcctt ctcagagaaa agagttaaac tgagtatctt     1200 
 
cttctgggga aatactggca ggccgagatg ggatccatag gagagcaaca acagaccatg     1260 
 
tcagacatcc tgtgtgcatt tatcgctgga tcctgaaaat agccccgtga aggcagaaat     1320 
 
gtatgtgact agaacgaggc cacatgaata agccactgcc cactggcagg agtgaaaact     1380 
 
gaagcgctcc ttacctgaag gaccccaaaa ccatatagaa tagaataacc aggagttccg     1440 
 
cctgtgtcta aatgcctctt ttcctgtatc acacaagggt cagggatggt ggagtaaaag     1500 
 
ctctccccct gggaggcttc tggaggctgt ccccatgtgc ttgcctagtt ccccactctg     1560 
 
ccctcctcct cttctctcag tctgctcctg gaacacctgc ctcagtttcc atgctctctc     1620 
 
cagtgccctc cccggtgaag caggtaggtg ttcaggccac cacagagaca atctctgtgg     1680 
 
gagattgtct tgcaatctcc cacagatttc aatcaggatt ttgttatttc ctactttgag     1740 
 
ctttaaaggg aaatgggcct catgggtggg gaaaggatgg tgggtccttc cagcccaatt     1800 
 
tagtgatgcc cagggcagat attatcctca gttcccaaga gcaatcatac ttttccacac     1860 
 
ataccgtgtg tctcatgtta ggtaaatgta tttttacaat gagcaccact tctgtggaaa     1920 
 
aagttccctg cacggggagg tccagcttcc agactgctcc atcgcataag gacttcccca     1980 
 
ttcccctaaa tgctgctctg tcagaacctg cccaggtaat ggtaatgacc ctagagagat     2040 
 
gatttctgaa ccgcaatttt gagcccatta gaaggtgtgt ggtgggcatt tatttcatcc     2100 
 
tgatgctctg gtgagaatct ttgcagacgc actagatcca gaagctgtta atcttggtgc     2160 
 
atttattttc ctacctaaaa gaaccaagca gctcagaggc agtgactgta caggatgcag     2220 
 
tgtttataat aatgctgagc ttgctggtct ggaaccccac actttagcaa tcccagcatt     2280 
 
gttcctgttt atgaagttga caaagtgacc agggcaaggg ggtattatca ttaaatacac     2340 
 
tctaggagag gcagaacaca tgagggcaat gtttttcaga ggtctttagg ccaccgcatc     2400 
 
agattctcct ggagcataaa gcaaatgctt tatgagtcca gggcccctgc agacctactg     2460 
 
tatactagta tacagctccc tcttagtgga tctcaagctt gtttccaaaa agtcattaca     2520 
 
ctccttacca aagcccatga cacattcata cagattcatc cagacataac ccactgcatg     2580 
 
gtccagtgca tgcttgtgtg cttaacttat tatagatcaa gtgttattta agtccaacat     2640 
 
attaaacgtg actgaaatat tatatgcact aaatcggaag acaaatggcc gtgctggata     2700 
 
ctctcccatt tgcacttaca ggccacgcca tgctccatcc tccccatcct gcctgggaac     2760 
 
ctgaccaatg tggctaaacc agcaggctcc ctggctgcca gcttctggct ggttgagcca     2820 
 
atgggaagca tgagaggaga gccgagggtg gggagacagt cagatcaggg tttctgtcct     2880 
 
cagggctccc tccctggcag gtggtggcag gagtggctgc attcccctct gaaggctcct     2940 
 
tcaagcctct cagcaaacag ctcccatctc caagtccagc cacctgttcc atcctctcct     3000 
 
ctgtaggccc agcagtggga atgacccacc actattgcca gcctcagcat actgaagcac     3060 
 
cccttactgg attccctaaa ttctatgcac atgtttatta aatgctcctc aattacccag     3120 
 
ttaaaaaaaa aaaaaaaaaa                                                 3140 
 
 
<210>  7 
<211>  233 
<212>  PRT 
<213>  Macaca fascicularis 
 
<400>  7 
 
Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser  
1               5                   10                  15       
 
 
Glu Leu Arg Ala Thr Thr Glu Leu Thr Glu Glu Lys Tyr Glu Tyr Lys  
            20                  25                  30           
 
 
Glu Gly Gln Thr Leu Glu Val Lys Cys Asp Tyr Ala Leu Glu Lys Tyr  
        35                  40                  45               
 
 
Ala Asn Ser Arg Lys Ala Trp Gln Lys Met Glu Gly Lys Met Pro Lys  
    50                  55                  60                   
 
 
Ile Leu Ala Lys Thr Glu Arg Pro Ser Glu Asn Ser His Pro Val Gln  
65                  70                  75                  80   
 
 
Val Gly Arg Ile Thr Leu Glu Asp Tyr Pro Asp His Gly Leu Leu Gln  
                85                  90                  95       
 
 
Val Gln Met Thr Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln Cys  
            100                 105                 110          
 
 
Val Ile Tyr Gln His Pro Lys Glu Ser His Val Leu Phe Asn Pro Ile  
        115                 120                 125              
 
 
Cys Leu Val Val Thr Lys Gly Ser Ser Gly Thr Pro Gly Ser Ser Glu  
    130                 135                 140                  
 
 
Asn Ser Thr Gln Asn Val Tyr Arg Thr Pro Ser Thr Thr Ala Lys Ala  
145                 150                 155                 160  
 
 
Leu Gly Pro Arg Tyr Thr Ser Pro Arg Thr Val Thr Gln Ala Pro Pro  
                165                 170                 175      
 
 
Glu Ser Thr Val Val Val Ser Thr Pro Gly Ser Glu Ile Asn Leu Thr  
            180                 185                 190          
 
 
Asn Val Thr Asp Ile Ile Arg Val Pro Val Phe Asn Ile Val Ile Ile  
        195                 200                 205              
 
 
Val Ala Gly Gly Phe Leu Ser Lys Ser Leu Val Phe Ser Val Leu Phe  
    210                 215                 220                  
 
 
Ala Val Thr Leu Arg Ser Phe Gly Pro  
225                 230              
 
 
<210>  8 
<211>  196 
<212>  PRT 
<213>  Homo Sapien 
 
<400>  8 
 
Met Ser Arg Arg Ser Met Leu Leu Ala Trp Ala Leu Pro Ser Leu Leu  
1               5                   10                  15       
 
 
Arg Leu Gly Ala Ala Gln Glu Thr Glu Asp Pro Ala Cys Cys Ser Pro  
            20                  25                  30           
 
 
Ile Val Pro Arg Asn Glu Trp Lys Ala Leu Ala Ser Glu Cys Ala Gln  
        35                  40                  45               
 
 
His Leu Ser Leu Pro Leu Arg Tyr Val Val Val Ser His Thr Ala Gly  
    50                  55                  60                   
 
 
Ser Ser Cys Asn Thr Pro Ala Ser Cys Gln Gln Gln Ala Arg Asn Val  
65                  70                  75                  80   
 
 
Gln His Tyr His Met Lys Thr Leu Gly Trp Cys Asp Val Gly Tyr Asn  
                85                  90                  95       
 
 
Phe Leu Ile Gly Glu Asp Gly Leu Val Tyr Glu Gly Arg Gly Trp Asn  
            100                 105                 110          
 
 
Phe Thr Gly Ala His Ser Gly His Leu Trp Asn Pro Met Ser Ile Gly  
        115                 120                 125              
 
 
Ile Ser Phe Met Gly Asn Tyr Met Asp Arg Val Pro Thr Pro Gln Ala  
    130                 135                 140                  
 
 
Ile Arg Ala Ala Gln Gly Leu Leu Ala Cys Gly Val Ala Gln Gly Ala  
145                 150                 155                 160  
 
 
Leu Arg Ser Asn Tyr Val Leu Lys Gly His Arg Asp Val Gln Arg Thr  
                165                 170                 175      
 
 
Leu Ser Pro Gly Asn Gln Leu Tyr His Leu Ile Gln Asn Trp Pro His  
            180                 185                 190          
 
 
Tyr Arg Ser Pro  
        195      
 
 
<210>  9 
<211>  11 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  Amino Acid Residues 27-37 of Human TREM-1, Isoform 1 
 
<400>  9 
 
Glu Lys Tyr Glu Leu Lys Glu Gly Gln Thr Leu  
1               5                   10       
 
 
<210>  10 
<211>  13 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  Amino Acid Residues 88-100 of Human TREM-1, Isoform 1 
 
<400>  10 
 
Glu Asp Tyr His Asp His Gly Leu Leu Arg Val Arg Met  
1               5                   10               
 
 
<210>  11 
<211>  9 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  Amino Acid Residues 120-128 of Human TREM-1, Isoform 1 
 
<400>  11 
 
Lys Glu Pro His Met Leu Phe Asp Arg  
1               5                    
 
 
<210>  12 
<211>  330 
<212>  PRT 
<213>  Homo sapiens 
 
<400>  12 
 
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys  
1               5                   10                  15       
 
 
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr  
            20                  25                  30           
 
 
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser  
        35                  40                  45               
 
 
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser  
    50                  55                  60                   
 
 
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr  
65                  70                  75                  80   
 
 
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys  
                85                  90                  95       
 
 
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys  
            100                 105                 110          
 
 
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro  
        115                 120                 125              
 
 
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys  
    130                 135                 140                  
 
 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp  
145                 150                 155                 160  
 
 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu  
                165                 170                 175      
 
 
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu  
            180                 185                 190          
 
 
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn  
        195                 200                 205              
 
 
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly  
    210                 215                 220                  
 
 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu  
225                 230                 235                 240  
 
 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr  
                245                 250                 255      
 
 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn  
            260                 265                 270          
 
 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe  
        275                 280                 285              
 
 
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn  
    290                 295                 300                  
 
 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr  
305                 310                 315                 320  
 
 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys  
                325                 330  
 
 
<210>  13 
<211>  124 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047248 VH 
 
<400>  13 
 
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu  
1               5                   10                  15       
 
 
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser  
            20                  25                  30           
 
 
Tyr Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile  
        35                  40                  45               
 
 
Gly Tyr Thr His Tyr Ser Gly Ile Ser Asn Tyr Asn Pro Ser Leu Lys  
    50                  55                  60                   
 
 
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu  
65                  70                  75                  80   
 
 
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala  
                85                  90                  95       
 
 
Arg Glu Gly Tyr Asp Ile Leu Thr Gly Tyr Glu Tyr Tyr Gly Met Asp  
            100                 105                 110          
 
 
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser  
        115                 120                  
 
 
<210>  14 
<211>  107 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047248 VL 
 
<400>  14 
 
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly  
1               5                   10                  15       
 
 
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser  
            20                  25                  30           
 
 
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu  
        35                  40                  45               
 
 
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser  
    50                  55                  60                   
 
 
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu  
65                  70                  75                  80   
 
 
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys  
            100                 105          
 
 
<210>  15 
<211>  122 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047246, P1-047247 VH 
 
<400>  15 
 
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu  
1               5                   10                  15       
 
 
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Asn Tyr  
            20                  25                  30           
 
 
Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile  
        35                  40                  45               
 
 
Gly Tyr Ile Tyr Asp Ser Gly Tyr Thr Asn Tyr Asn Pro Ser Leu Lys  
    50                  55                  60                   
 
 
Ser Arg Val Thr Leu Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu  
65                  70                  75                  80   
 
 
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala  
                85                  90                  95       
 
 
Arg Gly Val Leu Trp Phe Gly Glu Leu Leu Pro Leu Leu Asp Tyr Trp  
            100                 105                 110          
 
 
Gly Gln Gly Thr Leu Val Thr Val Ser Ser  
        115                 120          
 
 
<210>  16 
<211>  107 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047246; P1-047239 VL 
 
<400>  16 
 
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
 
 
Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Tyr  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys  
            100                 105          
 
 
<210>  17 
<211>  108 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047247 VL 
 
<400>  17 
 
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly  
1               5                   10                  15       
 
 
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser  
            20                  25                  30           
 
 
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu  
        35                  40                  45               
 
 
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Glu Arg Phe Ser  
    50                  55                  60                   
 
 
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu  
65                  70                  75                  80   
 
 
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro  
                85                  90                  95       
 
 
Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys  
            100                 105              
 
 
<210>  18 
 
<400>  18 
000 
 
<210>  19 
 
<400>  19 
000 
 
<210>  20 
 
<400>  20 
000 
 
<210>  21 
 
<400>  21 
000 
 
<210>  22 
 
<400>  22 
000 
 
<210>  23 
<211>  123 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047334 VH  
 
<400>  23 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Ser  
            20                  25                  30           
 
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Gly Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Ala Met Val Arg Gly Asn Tyr Phe Tyr Phe Tyr Gly Met Asp Val  
            100                 105                 110          
 
 
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser  
        115                 120              
 
 
<210>  24 
<211>  107 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047334 VL 
 
<400>  24 
 
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys  
            100                 105          
 
 
<210>  25 
<211>  125 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047239 VH 
 
<400>  25 
 
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg  
1               5                   10                  15       
 
 
Ser Leu Arg Leu Ser Cys Ala Ala Thr Glu Phe Thr Phe Ser Asn Tyr  
            20                  25                  30           
 
 
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val  
        35                  40                  45               
 
 
Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val  
    50                  55                  60                   
 
 
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr  
65                  70                  75                  80   
 
 
Leu Gln Leu Asn Ser Leu Ser Ala Glu Asp Ser Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Asp Gly Arg His Tyr Tyr Gly Ser Thr Ser Tyr Phe Gly Met  
            100                 105                 110          
 
 
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser  
        115                 120                 125  
 
 
<210>  26 
<211>  5 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047248 HCDR1 
 
<400>  26 
 
Ser Ser Tyr Trp Ser  
1               5    
 
 
<210>  27 
<211>  16 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047248 HCDR2 
 
<400>  27 
 
Tyr Thr His Tyr Ser Gly Ile Ser Asn Tyr Asn Pro Ser Leu Lys Ser  
1               5                   10                  15       
 
 
<210>  28 
<211>  16 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047248 HCDR3 
 
<400>  28 
 
Glu Gly Tyr Asp Ile Leu Thr Gly Tyr Glu Tyr Tyr Gly Met Asp Val  
1               5                   10                  15       
 
 
<210>  29 
<211>  12 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047248; P1-047247 LCDR1 
 
<400>  29 
 
Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala  
1               5                   10           
 
 
<210>  30 
<211>  7 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047248; P1-047247; P1-047317 LCDR2 
 
<400>  30 
 
Gly Ala Ser Ser Arg Ala Thr  
1               5            
 
 
<210>  31 
<211>  8 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047248 LCDR3 
 
<400>  31 
 
Gln Gln Tyr Gly Ser Ser Pro Thr  
1               5                
 
 
<210>  32 
<211>  5 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047246; P1-047247 HCDR1 
 
<400>  32 
 
Asn Tyr Tyr Trp Thr  
1               5    
 
 
<210>  33 
<211>  16 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047246; P1-047247 HCDR2 
 
<400>  33 
 
Tyr Ile Tyr Asp Ser Gly Tyr Thr Asn Tyr Asn Pro Ser Leu Lys Ser  
1               5                   10                  15       
 
 
<210>  34 
<211>  14 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047246; P1-047247 HCDR3 
 
<400>  34 
 
Gly Val Leu Trp Phe Gly Glu Leu Leu Pro Leu Leu Asp Tyr  
1               5                   10                   
 
 
<210>  35 
<211>  11 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047246; P1-047334; P1-047239; P1-047323; P1-047328 LCDR1 
 
<400>  35 
 
Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala  
1               5                   10       
 
 
<210>  36 
<211>  7 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047246; P1-047239; P1-047323; P1-047328 LCDR2 
 
<400>  36 
 
Asp Ala Ser Ser Leu Glu Ser  
1               5            
 
 
<210>  37 
<211>  9 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047246; P1-047239 LCDR3 
 
<400>  37 
 
Gln Gln Phe Asn Ser Tyr Pro Tyr Thr  
1               5                    
 
 
<210>  38 
<211>  9 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047247; P1-047317 LCDR3 
 
<400>  38 
 
Gln Gln Tyr Gly Ser Ser Pro Leu Thr  
1               5                    
 
 
<210>  39 
 
<400>  39 
000 
 
<210>  40 
 
<400>  40 
000 
 
<210>  41 
 
<400>  41 
000 
 
<210>  42 
<211>  11 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047317 LCDR1 
 
<400>  42 
 
Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala  
1               5                   10       
 
 
<210>  43 
 
<400>  43 
000 
 
<210>  44 
 
<400>  44 
000 
 
<210>  45 
<211>  5 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047334; P1-047292; P1-047289; P1-047306 HCDR1 
 
<400>  45 
 
Ser Ser Ala Ile Ser  
1               5    
 
 
<210>  46 
<211>  17 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047334 HCDR2 
 
<400>  46 
 
Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Gly Ala Gln Lys Phe Gln  
1               5                   10                  15       
 
 
Gly  
     
 
 
<210>  47 
<211>  14 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047334 HCDR3 
 
<400>  47 
 
Met Val Arg Gly Asn Tyr Phe Tyr Phe Tyr Gly Met Asp Val  
1               5                   10                   
 
 
<210>  48 
<211>  7 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047334; P1-047305; P1-047309; P1-047313; P1-047311; P1-047294; P1-047290; P1-047291; P1-047296; P1-047297; P1-047300; P1-047302; P1-047307; P1-047308; P1-047319; P1-047292; P1-047322; P1-047310; P1-047299; P1-047301; P1-047289; P1-047306; P1-047312; P1-047314; P1-047318; P1-047320; P1-047263; P1-047265 LCDR2 
 
<400>  48 
 
Ala Ala Ser Ser Leu Gln Ser  
1               5            
 
 
<210>  49 
<211>  9 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047334; P1-047307; P1-047311; P1-047294; P1-047297; P1-047300; P1-047302; P1-047310; P1-047306 LCDR3 
 
<400>  49 
 
Gln Gln Tyr Asn Ser Tyr Pro Leu Thr  
1               5                    
 
 
<210>  50 
<211>  5 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047239 HCDR1 
 
<400>  50 
 
Asn Tyr Gly Met His  
1               5    
 
 
<210>  51 
<211>  17 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047239 HCDR2 
 
<400>  51 
 
Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys  
1               5                   10                  15       
 
 
Gly  
     
 
 
<210>  52 
<211>  16 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047239 HCDR3 
 
<400>  52 
 
Asp Gly Arg His Tyr Tyr Gly Ser Thr Ser Tyr Phe Gly Met Asp Val  
1               5                   10                  15       
 
 
<210>  53 
<211>  126 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047305 VH 
 
<400>  53 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Gly Thr Phe Ser Ser Ser  
            20                  25                  30           
 
 
Ala Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Thr Pro Ile Phe Gly Thr Ala Asp Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Ala Ser Thr Ser Thr Gly Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Phe Thr Pro Arg Tyr Arg Gly Ser Ser His His Tyr Tyr Tyr Ala  
            100                 105                 110          
 
 
Leu Gly Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser  
        115                 120                 125      
 
 
<210>  54 
<211>  107 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047305; P1-047314; P1-047290; P1-047308; P1-047292; P1-047322; P1-047301; P1-047265 VL 
 
<400>  54 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys  
            100                 105          
 
 
<210>  55 
<211>  117 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047309 VH 
 
<400>  55 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Asn Pro Ser Gly Gly Thr Phe Ser Thr Tyr  
            20                  25                  30           
 
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Asn Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Pro Gly Tyr  
65                  70                  75                  80   
 
 
Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Gly Gly Ala Val Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu  
            100                 105                 110          
 
 
Val Thr Val Ser Ser  
        115          
 
 
<210>  56 
<211>  107 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047309 VL 
 
<400>  56 
 
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Phe  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys  
            100                 105          
 
 
<210>  57 
<211>  125 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047313 VH 
 
<400>  57 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr  
            20                  25                  30           
 
 
Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Arg Phe  
    50                  55                  60                   
 
 
Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu  
            100                 105                 110          
 
 
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser  
        115                 120                 125  
 
 
<210>  58 
<211>  107 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047313 VL 
 
<400>  58 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Trp  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys  
            100                 105          
 
 
<210>  59 
<211>  125 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047307; P1-047312; P1-047314; P1-047320; P1-047317 VH 
 
<400>  59 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr  
            20                  25                  30           
 
 
Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Gln Phe  
    50                  55                  60                   
 
 
Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu  
            100                 105                 110          
 
 
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser  
        115                 120                 125  
 
 
<210>  60 
<211>  107 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047307; P1-047302; P1-047306 VL 
 
<400>  60 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys  
            100                 105          
 
 
<210>  61 
<211>  107 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047312; P1-047318 VL 
 
<400>  61 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys  
            100                 105          
 
 
<210>  62 
<211>  125 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047318 VH 
 
<400>  62 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr  
            20                  25                  30           
 
 
Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Gln Phe  
    50                  55                  60                   
 
 
Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu  
            100                 105                 110          
 
 
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser  
        115                 120                 125  
 
 
<210>  63 
<211>  107 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047320; P1-047319 VL 
 
<400>  63 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys  
            100                 105          
 
 
<210>  64 
<211>  125 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047311 VH 
 
<400>  64 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr  
            20                  25                  30           
 
 
Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Gln Phe  
    50                  55                  60                   
 
 
Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu  
            100                 105                 110          
 
 
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser  
        115                 120                 125  
 
 
<210>  65 
<211>  107 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047311 VL 
 
<400>  65 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys  
            100                 105          
 
 
<210>  66 
<211>  127 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047294 VH 
 
<400>  66 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg His  
            20                  25                  30           
 
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Glu Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Ala Ala Asp Glu Pro Thr Ser Thr Thr Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Ser Ser Tyr Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr  
            100                 105                 110          
 
 
Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser  
        115                 120                 125          
 
 
<210>  67 
<211>  107 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047294 VL 
 
<400>  67 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys  
            100                 105          
 
 
<210>  68 
<211>  127 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047290; P1-047291; P1-047296; P1-047297; P1-047300; P1-047302 VH 
 
<400>  68 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg His  
            20                  25                  30           
 
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Ala Ala Asp Glu Pro Thr Ser Thr Thr Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Ser Ser Tyr Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr  
            100                 105                 110          
 
 
Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser  
        115                 120                 125          
 
 
<210>  69 
<211>  107 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047291 VL 
 
<400>  69 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys  
            100                 105          
 
 
<210>  70 
<211>  107 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047296 VL 
 
<400>  70 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Ile  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys  
            100                 105          
 
 
<210>  71 
<211>  107 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047297 VL 
 
<400>  71 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys  
            100                 105          
 
 
<210>  72 
<211>  107 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047300 VL 
 
<400>  72 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
His Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys  
            100                 105          
 
 
<210>  73 
<211>  125 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047308; P1-047319 VH 
 
<400>  73 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr  
            20                  25                  30           
 
 
Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu  
            100                 105                 110          
 
 
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser  
        115                 120                 125  
 
 
<210>  74 
<211>  126 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047292 VH 
 
<400>  74 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Ser  
            20                  25                  30           
 
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Ile Phe Ser Thr Gly Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Asp Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Ser Thr Arg Val Arg Gly Val Ser His Tyr Tyr Tyr Tyr Gly  
            100                 105                 110          
 
 
Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser  
        115                 120                 125      
 
 
<210>  75 
<211>  127 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047322 VH 
 
<400>  75 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ser Ser Gly Gly Thr Phe Ser Ser Tyr  
            20                  25                  30           
 
 
Ala Phe Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Ile Phe Arg Thr Ala Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Ser Ser His Phe Ser Gly Ser Gly Ser Ser His Tyr Tyr Tyr Tyr  
            100                 105                 110          
 
 
Gly Met His Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser  
        115                 120                 125          
 
 
<210>  76 
<211>  125 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047310 VH 
 
<400>  76 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Arg Tyr  
            20                  25                  30           
 
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ser Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Lys Ala Asp Glu Ser Thr Ser Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Gly Gly Asn Ser Trp Thr Thr Ser Leu Tyr Tyr Tyr Gly Met  
            100                 105                 110          
 
 
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser  
        115                 120                 125  
 
 
<210>  77 
<211>  107 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047310 VL 
 
<400>  77 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys  
            100                 105          
 
 
<210>  78 
<211>  127 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047299 VH 
 
<400>  78 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg Tyr  
            20                  25                  30           
 
 
Ala Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Ile Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Ser Ser His Phe Tyr Gly Ser Gly Ser Ser His Phe Tyr Tyr Tyr  
            100                 105                 110          
 
 
Gly Met His Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser  
        115                 120                 125          
 
 
<210>  79 
<211>  107 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047299 VL 
 
<400>  79 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Trp  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys  
            100                 105          
 
 
<210>  80 
<211>  127 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047301 VH 
 
<400>  80 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg Tyr  
            20                  25                  30           
 
 
Ala Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Ile Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Ser Ser His Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr  
            100                 105                 110          
 
 
Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser  
        115                 120                 125          
 
 
<210>  81 
<211>  126 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047289 VH 
 
<400>  81 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Ser  
            20                  25                  30           
 
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asp Ser Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Phe Thr Pro Arg Tyr Arg Gly Ser Ser His His Tyr Phe Tyr Ala  
            100                 105                 110          
 
 
Leu Gly Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser  
        115                 120                 125      
 
 
<210>  82 
<211>  107 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047289 VL 
 
<400>  82 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys  
            100                 105          
 
 
<210>  83 
<211>  125 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047306 VH 
 
<400>  83 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Ser  
            20                  25                  30           
 
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Ala Ser Gln Ser Arg Ser Ser Asn Tyr Tyr Tyr Tyr Gly Leu  
            100                 105                 110          
 
 
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser  
        115                 120                 125  
 
 
<210>  84 
<211>  5 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047305 HCDR1 
 
<400>  84 
 
Ser Ser Ala Val Ser  
1               5    
 
 
<210>  85 
<211>  17 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047305 HCDR2 
 
<400>  85 
 
Gly Ile Thr Pro Ile Phe Gly Thr Ala Asp Tyr Ala Gln Lys Phe Gln  
1               5                   10                  15       
 
 
Gly  
     
 
 
<210>  86 
<211>  17 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047305 HCDR3 
 
<400>  86 
 
Thr Pro Arg Tyr Arg Gly Ser Ser His His Tyr Tyr Tyr Ala Leu Gly  
1               5                   10                  15       
 
 
Val  
     
 
 
<210>  87 
<211>  11 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047305; P1-047309; P1-047313; P1-047307; P1-047312; P1-047314; P1-047318; P1-047320; P1-047311; P1-047294; P1-047290; P1-047291; P1-047296; P1-047297; P1-047300; P1-047302; P1-047308; P1-047319; P1-047292; P1-047322; P1-047310; P1-047299; P1-047301; P1-047289; P1-047306; P1-047263; P1-047265 LCDR1 
 
<400>  87 
 
Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala  
1               5                   10       
 
 
<210>  88 
<211>  9 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047305; P1-047312; P1-047314; P1-047318; P1-047320; P1-047290; P1-047291; P1-047308; P1-047319; P1-047292; P1-047322; P1-047301; P1-047265 LCDR3 
 
<400>  88 
 
Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr  
1               5                    
 
 
<210>  89 
<211>  5 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047309 HCDR1 
 
<400>  89 
 
Thr Tyr Ala Ile Ser  
1               5    
 
 
<210>  90 
<211>  17 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047309 HCDR2 
 
<400>  90 
 
Gly Ile Asn Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln  
1               5                   10                  15       
 
 
Gly  
     
 
 
<210>  91 
<211>  8 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047309 HCDR3 
 
<400>  91 
 
Gly Gly Ala Val Gly Phe Ala Tyr  
1               5                
 
 
<210>  92 
<211>  9 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047309 LCDR3 
 
<400>  92 
 
Gln Gln Ala Asn Ser Phe Pro Phe Thr  
1               5                    
 
 
<210>  93 
<211>  5 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047313; P1-047307; P1-047312; P1-047314; P1-047318; P1-047320; P1-047311; P1-047308; P1-047319; P1-047317 HCDR1 
 
<400>  93 
 
Ile Tyr Val Ile Ser  
1               5    
 
 
<210>  94 
<211>  17 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047313 HCDR2 
 
<400>  94 
 
Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Arg Phe Gln  
1               5                   10                  15       
 
 
Asp  
     
 
 
<210>  95 
<211>  16 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047313; P1-047307; P1-047312; P1-047314; P1-047318; P1-047320; P1-047311; P1-047308; P1-047319; P1-047317 HCDR3 
 
<400>  95 
 
Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu Asp Val  
1               5                   10                  15       
 
 
<210>  96 
<211>  9 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047313; P1-047299 LCDR3 
 
<400>  96 
 
Gln Gln Tyr Asn Ser Tyr Pro Trp Thr  
1               5                    
 
 
<210>  97 
<211>  17 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047307; P1-047312; P1-047314; P1-047318; P1-047320; P1-047317 HCDR2 
 
<400>  97 
 
Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Gln Phe Gln  
1               5                   10                  15       
 
 
Asp  
     
 
 
<210>  98 
<211>  17 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047311 HCDR2 
 
<400>  98 
 
Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Gln Phe Gln  
1               5                   10                  15       
 
 
Asp  
     
 
 
<210>  99 
<211>  5 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047294; P1-047290; P1-047291; P1-047296; P1-047297; P1-047300; P1-047302 HCDR1 
 
<400>  99 
 
Arg His Ala Ile Ser  
1               5    
 
 
<210>  100 
<211>  17 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047294 HCDR2 
 
<400>  100 
 
Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Glu Phe Gln  
1               5                   10                  15       
 
 
Gly  
     
 
 
<210>  101 
<211>  18 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047294; P1-047291; P1-047296; P1-047297; P1-047300; P1-047302 HCDR3 
 
<400>  101 
 
Ser Tyr Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr Gly Leu  
1               5                   10                  15       
 
 
Asp Val  
         
 
 
<210>  102 
<211>  17 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047290; P1-047291; P1-047296; P1-047297; P1-047300; P1-047302; P1-047308; P1-047319 HCDR2 
 
<400>  102 
 
Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln  
1               5                   10                  15       
 
 
Gly  
     
 
 
<210>  103 
<211>  9 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047296; P1-047328 LCDR3 
 
<400>  103 
 
Gln Gln Tyr Asn Ser Tyr Pro Ile Thr  
1               5                    
 
 
<210>  104 
<211>  17 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047292 HCDR2 
 
<400>  104 
 
Gly Ile Ile Pro Ile Phe Ser Thr Gly Asn Tyr Ala Gln Lys Phe Gln  
1               5                   10                  15       
 
 
Gly  
     
 
 
<210>  105 
<211>  17 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047292 HCDR3 
 
<400>  105 
 
Ser Thr Arg Val Arg Gly Val Ser His Tyr Tyr Tyr Tyr Gly Leu Asp  
1               5                   10                  15       
 
 
Val  
     
 
 
<210>  106 
<211>  5 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047322 HCDR1 
 
<400>  106 
 
Ser Tyr Ala Phe Thr  
1               5    
 
 
<210>  107 
<211>  17 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047322 HCDR2 
 
<400>  107 
 
Gly Ile Ile Pro Ile Phe Arg Thr Ala Asn Tyr Ala Gln Lys Phe Gln  
1               5                   10                  15       
 
 
Gly  
     
 
 
<210>  108 
<211>  18 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047322 HCDR3 
 
<400>  108 
 
Ser His Phe Ser Gly Ser Gly Ser Ser His Tyr Tyr Tyr Tyr Gly Met  
1               5                   10                  15       
 
 
His Val  
         
 
 
<210>  109 
<211>  5 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047310 HCDR1 
 
<400>  109 
 
Arg Tyr Ala Ile Ser  
1               5    
 
 
<210>  110 
<211>  17 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047310 HCDR2 
 
<400>  110 
 
Gly Ile Ile Pro Ile Phe Gly Thr Ser Asn Tyr Ala Gln Lys Phe Gln  
1               5                   10                  15       
 
 
Gly  
     
 
 
<210>  111 
<211>  16 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047310 HCDR3 
 
<400>  111 
 
Gly Gly Asn Ser Trp Thr Thr Ser Leu Tyr Tyr Tyr Gly Met Asp Val  
1               5                   10                  15       
 
 
<210>  112 
<211>  5 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047299; P1-047301 HCDR1 
 
<400>  112 
 
Arg Tyr Ala Phe Ser  
1               5    
 
 
<210>  113 
<211>  17 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047299; P1-047301 HCDR2 
 
<400>  113 
 
Gly Ile Ile Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe Gln  
1               5                   10                  15       
 
 
Gly  
     
 
 
<210>  114 
<211>  18 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047299 HCDR3 
 
<400>  114 
 
Ser His Phe Tyr Gly Ser Gly Ser Ser His Phe Tyr Tyr Tyr Gly Met  
1               5                   10                  15       
 
 
His Val  
         
 
 
<210>  115 
<211>  18 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047301 HCDR3 
 
<400>  115 
 
Ser His Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr Gly Leu  
1               5                   10                  15       
 
 
Asp Val  
         
 
 
<210>  116 
<211>  17 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047289 HCDR2 
 
<400>  116 
 
Gly Ile Ile Pro Ile Phe Gly Thr Ala Asp Ser Ala Gln Lys Phe Gln  
1               5                   10                  15       
 
 
Gly  
     
 
 
<210>  117 
<211>  17 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047289 HCDR3 
 
<400>  117 
 
Thr Pro Arg Tyr Arg Gly Ser Ser His His Tyr Phe Tyr Ala Leu Gly  
1               5                   10                  15       
 
 
Val  
     
 
 
<210>  118 
<211>  9 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047289 LCDR3 
 
<400>  118 
 
Gln Gln Phe Asn Ser Tyr Pro Leu Thr  
1               5                    
 
 
<210>  119 
<211>  17 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047306 HCDR2 
 
<400>  119 
 
Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln  
1               5                   10                  15       
 
 
Gly  
     
 
 
<210>  120 
<211>  16 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047306 HCDR3 
 
<400>  120 
 
Ala Ser Gln Ser Arg Ser Ser Asn Tyr Tyr Tyr Tyr Gly Leu Asp Val  
1               5                   10                  15       
 
 
<210>  121 
<211>  330 
<212>  PRT 
<213>  Homo Sapien 
 
<400>  121 
 
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys  
1               5                   10                  15       
 
 
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr  
            20                  25                  30           
 
 
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser  
        35                  40                  45               
 
 
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser  
    50                  55                  60                   
 
 
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr  
65                  70                  75                  80   
 
 
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys  
                85                  90                  95       
 
 
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys  
            100                 105                 110          
 
 
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro  
        115                 120                 125              
 
 
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys  
    130                 135                 140                  
 
 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp  
145                 150                 155                 160  
 
 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu  
                165                 170                 175      
 
 
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu  
            180                 185                 190          
 
 
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn  
        195                 200                 205              
 
 
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly  
    210                 215                 220                  
 
 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu  
225                 230                 235                 240  
 
 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr  
                245                 250                 255      
 
 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn  
            260                 265                 270          
 
 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe  
        275                 280                 285              
 
 
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn  
    290                 295                 300                  
 
 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr  
305                 310                 315                 320  
 
 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys  
                325                 330  
 
 
<210>  122 
<211>  330 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  IgG1.1f HC Constant Region 
 
<400>  122 
 
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys  
1               5                   10                  15       
 
 
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr  
            20                  25                  30           
 
 
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser  
        35                  40                  45               
 
 
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser  
    50                  55                  60                   
 
 
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr  
65                  70                  75                  80   
 
 
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys  
                85                  90                  95       
 
 
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys  
            100                 105                 110          
 
 
Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro  
        115                 120                 125              
 
 
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys  
    130                 135                 140                  
 
 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp  
145                 150                 155                 160  
 
 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu  
                165                 170                 175      
 
 
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu  
            180                 185                 190          
 
 
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn  
        195                 200                 205              
 
 
Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly  
    210                 215                 220                  
 
 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu  
225                 230                 235                 240  
 
 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr  
                245                 250                 255      
 
 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn  
            260                 265                 270          
 
 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe  
        275                 280                 285              
 
 
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn  
    290                 295                 300                  
 
 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr  
305                 310                 315                 320  
 
 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys  
                325                 330  
 
 
<210>  123 
<211>  330 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  IgG1.3f HC Constant Region 
 
<400>  123 
 
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys  
1               5                   10                  15       
 
 
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr  
            20                  25                  30           
 
 
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser  
        35                  40                  45               
 
 
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser  
    50                  55                  60                   
 
 
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr  
65                  70                  75                  80   
 
 
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys  
                85                  90                  95       
 
 
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys  
            100                 105                 110          
 
 
Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro  
        115                 120                 125              
 
 
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys  
    130                 135                 140                  
 
 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp  
145                 150                 155                 160  
 
 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu  
                165                 170                 175      
 
 
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu  
            180                 185                 190          
 
 
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn  
        195                 200                 205              
 
 
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly  
    210                 215                 220                  
 
 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu  
225                 230                 235                 240  
 
 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr  
                245                 250                 255      
 
 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn  
            260                 265                 270          
 
 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe  
        275                 280                 285              
 
 
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn  
    290                 295                 300                  
 
 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr  
305                 310                 315                 320  
 
 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys  
                325                 330  
 
 
<210>  124 
<211>  330 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  IgG1-Aba HC Constant Region 
 
<400>  124 
 
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys  
1               5                   10                  15       
 
 
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr  
            20                  25                  30           
 
 
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser  
        35                  40                  45               
 
 
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser  
    50                  55                  60                   
 
 
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr  
65                  70                  75                  80   
 
 
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys  
                85                  90                  95       
 
 
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser  
            100                 105                 110          
 
 
Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro  
        115                 120                 125              
 
 
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys  
    130                 135                 140                  
 
 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp  
145                 150                 155                 160  
 
 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu  
                165                 170                 175      
 
 
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu  
            180                 185                 190          
 
 
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn  
        195                 200                 205              
 
 
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly  
    210                 215                 220                  
 
 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu  
225                 230                 235                 240  
 
 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr  
                245                 250                 255      
 
 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn  
            260                 265                 270          
 
 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe  
        275                 280                 285              
 
 
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn  
    290                 295                 300                  
 
 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr  
305                 310                 315                 320  
 
 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys  
                325                 330  
 
 
<210>  125 
<211>  330 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  IgG4-Aba HC Constant Region 
 
<400>  125 
 
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg  
1               5                   10                  15       
 
 
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr  
            20                  25                  30           
 
 
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser  
        35                  40                  45               
 
 
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser  
    50                  55                  60                   
 
 
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr  
65                  70                  75                  80   
 
 
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys  
                85                  90                  95       
 
 
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser  
            100                 105                 110          
 
 
Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro  
        115                 120                 125              
 
 
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys  
    130                 135                 140                  
 
 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp  
145                 150                 155                 160  
 
 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu  
                165                 170                 175      
 
 
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu  
            180                 185                 190          
 
 
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn  
        195                 200                 205              
 
 
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly  
    210                 215                 220                  
 
 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu  
225                 230                 235                 240  
 
 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr  
                245                 250                 255      
 
 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn  
            260                 265                 270          
 
 
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe  
        275                 280                 285              
 
 
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn  
    290                 295                 300                  
 
 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr  
305                 310                 315                 320  
 
 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys  
                325                 330  
 
 
<210>  126 
<211>  107 
<212>  PRT 
<213>  Homo Sapien 
 
<400>  126 
 
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu  
1               5                   10                  15       
 
 
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe  
            20                  25                  30           
 
 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln  
        35                  40                  45               
 
 
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser  
    50                  55                  60                   
 
 
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu  
65                  70                  75                  80   
 
 
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser  
                85                  90                  95       
 
 
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys  
            100                 105          
 
 
<210>  127 
<211>  5 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  LSPGK (C-terminal end of heavy chain) 
 
<400>  127 
 
Leu Ser Pro Gly Lys  
1               5    
 
 
<210>  128 
<211>  4 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  LSPG (C-terminal end of heavy chain) 
 
<400>  128 
 
Leu Ser Pro Gly  
1                
 
 
<210>  129 
<211>  5 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  Linker 
 
<400>  129 
 
Pro Val Gly Val Val  
1               5    
 
 
<210>  130 
<211>  126 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047323; P1-047328 VH 
 
<400>  130 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ile Asn Ser  
            20                  25                  30           
 
 
Glu Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp  
        35                  40                  45               
 
 
Met Gly Gly Ile Ile Pro Ile Phe Asp Ile Thr Asn Tyr Ala Gln Lys  
    50                  55                  60                   
 
 
Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Met Ser Thr Ala  
65                  70                  75                  80   
 
 
Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr  
                85                  90                  95       
 
 
Cys Ala Lys Thr Tyr Tyr Asp Ile Leu Thr Tyr His Tyr His Tyr Gly  
            100                 105                 110          
 
 
Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser  
        115                 120                 125      
 
 
<210>  131 
<211>  107 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047323 VL 
 
<400>  131 
 
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
 
 
Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Ile  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys  
            100                 105          
 
 
<210>  132 
<211>  107 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047328 VL 
 
<400>  132 
 
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
 
 
Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Ile  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys  
            100                 105          
 
 
<210>  133 
<211>  126 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047263; P1-047265 VH 
 
<400>  133 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Pro Thr Tyr  
            20                  25                  30           
 
 
Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Trp Val Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Asp Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Ser Asp Gly Leu Asn Met Val Arg Gly Val His Asn Tyr Tyr Gly  
            100                 105                 110          
 
 
Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser  
        115                 120                 125      
 
 
<210>  134 
<211>  107 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047263 VL 
 
<400>  134 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Pro  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys  
            100                 105          
 
 
<210>  135 
<211>  107 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047317 VL 
 
<400>  135 
 
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly  
1               5                   10                  15       
 
 
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile  
        35                  40                  45               
 
 
Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys  
            100                 105          
 
 
<210>  136 
<211>  6 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047323; P1-047328 HCDR1 
 
<400>  136 
 
Asn Ser Glu Ala Ile Asn  
1               5        
 
 
<210>  137 
<211>  17 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047323; P1-047328 HCDR2 
 
<400>  137 
 
Gly Ile Ile Pro Ile Phe Asp Ile Thr Asn Tyr Ala Gln Lys Phe Gln  
1               5                   10                  15       
 
 
Gly  
     
 
 
<210>  138 
<211>  16 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047323; P1-047328 HCDR3 
 
<400>  138 
 
Thr Tyr Tyr Asp Ile Leu Thr Tyr His Tyr His Tyr Gly Met Asp Val  
1               5                   10                  15       
 
 
<210>  139 
<211>  9 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047323 LCDR3 
 
<400>  139 
 
Gln Gln Phe Asn Ser Tyr Pro Ile Thr  
1               5                    
 
 
<210>  140 
<211>  5 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047263; P1-047265 HCDR1 
 
<400>  140 
 
Thr Tyr Asp Ile Asn  
1               5    
 
 
<210>  141 
<211>  17 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047263; P1-047265 HCDR2 
 
<400>  141 
 
Trp Val Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe Gln  
1               5                   10                  15       
 
 
Asp  
     
 
 
<210>  142 
<211>  17 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047263; P1-047265 HCDR3 
 
<400>  142 
 
Asp Gly Leu Asn Met Val Arg Gly Val His Asn Tyr Tyr Gly Met Asp  
1               5                   10                  15       
 
 
Val  
     
 
 
<210>  143 
<211>  9 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047263 LCDR3 
 
<400>  143 
 
Gln Gln Tyr Asn Ser Tyr Pro Pro Thr  
1               5                    
 
 
<210>  144 
<211>  375 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047239 VH 
 
<400>  144 
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60 
 
tcctgtgcag ctactgaatt caccttcagt aactatggca tgcactgggt ccgccaggct      120 
 
ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaatactat      180 
 
gcagactccg tgaagggccg cttcaccatc tccagagaca attccaagaa cacgctgtat      240 
 
ctgcaattga acagcctgag cgccgaggac tcggctgtgt attactgtgc gagagatggg      300 
 
aggcattact atggttcgac ctcctacttc ggcatggacg tctggggcca agggaccacg      360 
 
gtcaccgtct cctca                                                       375 
 
 
<210>  145 
<211>  366 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047246; P1-047247 VH 
 
<400>  145 
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60 
 
acctgcactg tctctggtgg ctccatcact aattactact ggacctggat ccggcagccc      120 
 
ccagggaagg gactggagtg gattgggtat atctatgaca gtgggtacac caactacaac      180 
 
ccctccctca agagtcgagt caccttatca atagacacgt ccaagaacca gttctccctg      240 
 
aagctgagct ctgtgaccgc tgcggacacg gccgtttatt actgtgcgag aggggttcta      300 
 
tggttcgggg agttattacc tctccttgac tactggggcc agggaaccct ggtcaccgtc      360 
 
tcctca                                                                 366 
 
 
<210>  146 
<211>  372 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047248 VH 
 
<400>  146 
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60 
 
acctgcactg tgtctggtgg ctccatcagt agttcctact ggagctgggt ccggcagccc      120 
 
ccagggaagg gactggagtg gattggatat acccattaca gtgggatcag caactacaac      180 
 
ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240 
 
aagctgagct ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agaagggtac      300 
 
gatattttga ctggttatga gtactacggt atggacgtct ggggccaagg gaccacggtc      360 
 
accgtctcct ca                                                          372 
 
 
<210>  147 
<211>  378 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047323; P1-047328 VH 
 
<400>  147 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcatc aatagcgaag ctatcaactg ggtgcgacag      120 
 
gcccctggac aagggcttga gtggatggga gggatcatcc ctatctttga cattacaaac      180 
 
tacgcacaga agttccaggg cagagtcacg attaccgcgg acgaatccat gagcacagcc      240 
 
tacatggagc tgagcagcct gagatctgag gacacggccg tgtattactg tgcgaagacg      300 
 
tattacgata ttttgactta tcactatcac tacggtatgg acgtctgggg ccaagggacc      360 
 
acggtcaccg tctcctca                                                    378 
 
 
<210>  148 
<211>  369 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047334 VH 
 
<400>  148 
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc tgtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagt agttccgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac aacaaacggc      180 
 
gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240 
 
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc ggctatggtt      300 
 
cggggaaatt acttctactt ctacggtatg gacgtctggg gccaagggac cacggtcacc      360 
 
gtctcctca                                                              369 
 
 
<210>  149 
<211>  378 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047263; P1-047265 VH 
 
<400>  149 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60 
 
tcctgcaagg cttctggata caccttcccc acttatgata tcaactgggt gcgacaggcc      120 
 
actggacaag ggcttgagtg gatgggatgg gtgaacccta acagtggtaa cacaggctat      180 
 
gcacagaagt tccaggacag agtcaccatg accaggaaca cctccataag cacagcctac      240 
 
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagtgacggc      300 
 
cttaatatgg ttcggggagt tcacaactac tacggtatgg acgtctgggg ccaagggacc      360 
 
acggtcaccg tctcctca                                                    378 
 
 
<210>  150 
<211>  378 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047289 VH 
 
<400>  150 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagc agctctgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggagga atcatcccta tcttcggtac agcagactcc      180 
 
gcacagaagt tccagggcag agtcacgatt accgcggacg agtccacgag cacagcctac      240 
 
atggaattga acagcctgag atctgaggac acggccgttt actactgtgc gttcacaccc      300 
 
cggtatcgtg ggagctccca ccactacttc tacgctttgg gcgtctgggg ccaagggacc      360 
 
acggtcaccg tctcctca                                                    378 
 
 
<210>  151 
<211>  381 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047290; P1-047291; P1-047296; P1-047297 VH 
 
<400>  151 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcaac agacatgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180 
 
gcgcagaagt tccagggcag agtcacgatt gccgcggacg aacccacgag cacaacctac      240 
 
atggagctgc gcagcctgag atctgaggac acggccgtgt attactgtgc gagttcgtat      300 
 
ttctatggtt cggggagttc caactactac tactacggtt tggacgtctg gggccaaggg      360 
 
accacggtca ccgtctcctc a                                                381 
 
 
<210>  152 
<211>  378 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047292 VH 
 
<400>  152 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagc agctctgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttagtac aggaaactac      180 
 
gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgaa cacagcctac      240 
 
atggatctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatccact      300 
 
agggttcggg gagtttccca ctactactac tacggtttgg acgtctgggg ccaagggacc      360 
 
acggtcaccg tctcctca                                                    378 
 
 
<210>  153 
<211>  381 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047294 VH 
 
<400>  153 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcaac agacatgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180 
 
gcgcaggagt tccagggcag agtcacgatt gccgcggacg aacccacgag cacaacctac      240 
 
atggagctgc gcagcctgag atctgaggac acggccgtgt attactgtgc gagttcgtat      300 
 
ttctatggtt cggggagttc caactactac tactacggtt tggacgtctg gggccaaggg      360 
 
accacggtca ccgtctcctc a                                                381 
 
 
<210>  154 
<211>  381 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047299 VH 
 
<400>  154 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcaac agatatgctt tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac acccaactac      180 
 
gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacggcctac      240 
 
atggagctga gcagcctgat atctgaggac acggccgtgt attactgtgc gagcagccat      300 
 
ttctatggtt cggggagttc ccacttttac tactacggta tgcacgtctg gggccaaggg      360 
 
accacggtca ccgtctcctc a                                                381 
 
 
<210>  155 
<211>  381 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047300 VH 
 
<400>  155 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcaac agacatgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180 
 
gcgcagaagt tccagggcag agtcacgatt gccgcggacg aacccacgag cacaacctac      240 
 
atggagctgc gcagcctgag atctgaggac acggccgtgt attactgtgc aagttcgtat      300 
 
ttctatggtt cggggagttc caactactac tactacggtt tggacgtctg gggccaaggg      360 
 
accacggtca ccgtctcctc a                                                381 
 
 
<210>  156 
<211>  381 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047301 VH 
 
<400>  156 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcaac agatatgctt tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac acccaactac      180 
 
gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacggcctac      240 
 
atggagctga gcagcctgat atctgaggac acggccgtgt attactgtgc gagcagccat      300 
 
ttctatggtt cggggagttc caactactac tactacggtt tggacgtctg gggccaaggg      360 
 
accacggtca ccgtctcctc a                                                381 
 
 
<210>  157 
<211>  381 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047302 VH 
 
<400>  157 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcaac agacatgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180 
 
gcgcagaagt tccagggcag agtcacgatt gccgcggacg aacccacgag cacaacctac      240 
 
atggagctgc gcagcctgag atctgaggac acggccgtgt attactgtgc gagttcgtat      300 
 
ttctatggtt cggggagttc caactattac tactacggtt tggacgtctg gggccaaggg      360 
 
accacggtca ccgtctcctc a                                                381 
 
 
<210>  158 
<211>  378 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047305 VH 
 
<400>  158 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaaga cttctggagg caccttcagc agctctgctg tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgaatg gatgggagga atcaccccta tttttggtac agcagactac      180 
 
gcacagaagt tccagggcag agtcacgatt accgcggacg catccacgag cacaggttat      240 
 
atggaactga gcagcctgag atctgaggac acggccgttt actactgtgc gttcacaccc      300 
 
cgatatcgtg ggagctccca ccactactac tacgctttgg gcgtctgggg ccaagggacc      360 
 
acggtcaccg tctcctca                                                    378 
 
 
<210>  159 
<211>  375 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047306 VH 
 
<400>  159 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagc agctctgcta tcagctgggt acgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcgaactac      180 
 
gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240 
 
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagcctcc      300 
 
caaagcagga gctcgaacta ctactactac ggtctggacg tctggggcca agggaccacg      360 
 
gtcaccgtct cctca                                                       375 
 
 
<210>  160 
<211>  375 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047307; P1-047312; P1-047314; P1-047317; P1-047320 VH 
 
<400>  160 
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac accaaactac      180 
 
gcacagcagt tccaggacag agtcacgatt accgcggacg aatccacgag gacagcctac      240 
 
atggagctga atagcctgaa atctgaggac acggccgtat attactgtgc gaggggacat      300 
 
ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360 
 
gtcaccgtct cctca                                                       375 
 
 
<210>  161 
<211>  375 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047308; P1-047319 VH 
 
<400>  161 
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180 
 
gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgaa tacagcctac      240 
 
atggagctga gtagcctgag atctgaggac acggccgtgt attactgtgc gaggggacat      300 
 
ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360 
 
gtcaccgtct cctca                                                       375 
 
 
<210>  162 
<211>  351 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047309 VH 
 
<400>  162 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaacc cttctggagg caccttcagc acctacgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcaacccta tctttggaac agcaaactac      180 
 
gcacagaagt tccagggcag agtcacaatt accgcggacg aatccacgag tccaggctac      240 
 
ctggagctga gcagcctgag atctgaggac acggccgttt attactgtgc gagaggggga      300 
 
gcagtgggtt ttgcctattg gggccaggga accctggtca ccgtctcctc a               351 
 
 
<210>  163 
<211>  375 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047310 VH 
 
<400>  163 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagc agatatgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac atcaaactac      180 
 
gcacagaagt tccagggcag agtcacgatt aaagcggacg aatccacgag cacagcctac      240 
 
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagggggc      300 
 
aacagctgga ccactagttt gtactactac ggtatggacg tctggggcca agggaccacg      360 
 
gtcaccgtct cctca                                                       375 
 
 
<210>  164 
<211>  375 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047311 VH 
 
<400>  164 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180 
 
gcacagcagt tccaggacag agtcacgatt accgcggacg aatccacgag gacagcctac      240 
 
atggagctga atagcctgaa atctgaggac acggctgtat attactgtgc gaggggacat      300 
 
ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360 
 
gtcaccgtct cctca                                                       375 
 
 
<210>  165 
<211>  375 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047313 VH 
 
<400>  165 
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac accaaactac      180 
 
gcacagcggt tccaggacag agtcacgatt accgcggacg aatccacgag gacagcctac      240 
 
atggagctga gtagcctgag atctgaggac acggccgtgt attactgtgc gaggggacat      300 
 
ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360 
 
gtcaccgtct cctca                                                       375 
 
 
<210>  166 
<211>  375 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047318 VH 
 
<400>  166 
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt ccgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac accaaactac      180 
 
gcacagcagt tccaggacag agtcacgatt accgcggacg aatccacgag gacagcctac      240 
 
atggagctga gtagcctgag atctgaggac acggccgtgt attactgtgc gaggggacat      300 
 
ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360 
 
gtcaccgtct cctca                                                       375 
 
 
<210>  167 
 
<400>  167 
000 
 
<210>  168 
<211>  381 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047322 VH 
 
<400>  168 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagt cttctggagg caccttcagc agctatgctt tcacctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttcgtac agcaaactac      180 
 
gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240 
 
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagcagccat      300 
 
ttctctggtt cgggaagttc ccactactac tactacggta tgcacgtctg gggccaaggg      360 
 
accacggtca ccgtctcctc a                                                381 
 
 
<210>  169 
<211>  321 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047239; P1-047246 VL 
 
<400>  169 
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaacca      120 
 
gggaaagctc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgtcaacag tttaatagtt acccgtacac ttttggccag      300 
 
gggaccaagc tggagatcaa a                                                321 
 
 
<210>  170 
<211>  324 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047247 VL 
 
<400>  170 
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60 
 
ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120 
 
cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180 
 
gagaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240 
 
cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgct cactttcggc      300 
 
ggagggacca aggtggagat caaa                                             324 
 
 
<210>  171 
<211>  321 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047248 VL 
 
<400>  171 
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60 
 
ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120 
 
cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180 
 
gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240 
 
cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacctac tttcggcgga      300 
 
gggaccaagg tggagatcaa a                                                321 
 
 
<210>  172 
<211>  321 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047323 VL 
 
<400>  172 
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaacca      120 
 
gggaaagctc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgtcaacag tttaatagtt acccgatcac cttcggccaa      300 
 
gggacacgac tggagattaa a                                                321 
 
 
<210>  173 
 
<400>  173 
000 
 
<210>  174 
<211>  321 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047328 VL 
 
<400>  174 
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaacca      120 
 
gggaaagctc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgatcac cttcggccaa      300 
 
gggacacgac tggagattaa a                                                321 
 
 
<210>  175 
<211>  321 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047334 VL 
 
<400>  175 
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaacca      120 
 
gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgctcac tttcggcgga      300 
 
gggaccaagg tggagatcaa a                                                321 
 
 
<210>  176 
<211>  321 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047265; P1-047290; P1-047292; P1-047301; P1-047305; P1-047308; P1-047314 VL 
 
<400>  176 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300 
 
gggaccaagc tggagatcaa a                                                321 
 
 
<210>  177 
<211>  321 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047263 VL 
 
<400>  177 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt accctccgac ttttggccag      300 
 
gggaccaagc tggagatcaa a                                                321 
 
 
<210>  178 
 
<400>  178 
000 
 
<210>  179 
<211>  321 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047291 VL 
 
<400>  179 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gatgattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300 
 
gggaccaagc tggagatcaa a                                                321 
 
 
<210>  180 
<211>  321 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047294 VL 
 
<400>  180 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcggtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgctcac tttcggcgga      300 
 
gggaccaagg tggagatcaa a                                                321 
 
 
<210>  181 
<211>  321 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047297 VL 
 
<400>  181 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcataaacca      120 
 
gggaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgctcac tttcggcgga      300 
 
gggaccaagg tggagatcaa a                                                321 
 
 
<210>  182 
<211>  321 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047296 VL 
 
<400>  182 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgatcac cttcggccaa      300 
 
gggacacgac tggagattaa a                                                321 
 
 
<210>  183 
<211>  321 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047319; P1-047320 VL 
 
<400>  183 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcataaacca      120 
 
gggaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300 
 
gggaccaagc tggagatcaa a                                                321 
 
 
<210>  184 
<211>  321 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047302; P1-047306; P1-047307 VL 
 
<400>  184 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt accctctcac tttcggcgga      300 
 
gggaccaagg tggagatcaa a                                                321 
 
 
<210>  185 
<211>  321 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047300 VL 
 
<400>  185 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatccatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgctcac tttcggcgga      300 
 
gggaccaagg tggagatcaa a                                                321 
 
 
<210>  186 
<211>  321 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047309 VL 
 
<400>  186 
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcataaacca      120 
 
gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttacta ttgtcaacag gctaatagtt tcccgttcac tttcggcgga      300 
 
gggaccaagg tggagatcaa a                                                321 
 
 
<210>  187 
<211>  321 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047310 VL 
 
<400>  187 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacggat tacactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgctcac tttcggcgga      300 
 
gggaccaagg tggagatcaa a                                                321 
 
 
<210>  188 
<211>  321 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047311 VL 
 
<400>  188 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gggaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgctcac tttcggcgga      300 
 
gggaccaagg tggagatcaa a                                                321 
 
 
<210>  189 
<211>  321 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047312; P1-047318 VL 
 
<400>  189 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcataaacca      120 
 
gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300 
 
gggaccaagc tggagatcaa a                                                321 
 
 
<210>  190 
<211>  321 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047313 VL 
 
<400>  190 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcataaacca      120 
 
gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccctggac gttcggccaa      300 
 
gggaccaagg tggaaatcaa a                                                321 
 
 
<210>  191 
<211>  321 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047317 VL 
 
<400>  191 
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60 
 
ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120 
 
ggccaggctc ccaggctcct catctatggt gcatccagca gggccactgg catcccagac      180 
 
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct      240 
 
gaagattttg cagtgtatta ctgtcagcag tatggtagct caccgctcac tttcggcgga      300 
 
gggaccaagg tggagatcaa a                                                321 
 
 
<210>  192 
<211>  321 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047322 VL 
 
<400>  192 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggtttagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300 
 
gggaccaagc tggagatcaa a                                                321 
 
 
<210>  193 
<211>  448 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  mAb 0170 VH 
 
<400>  193 
 
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly  
1               5                   10                  15       
 
 
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr  
            20                  25                  30           
 
 
Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val  
        35                  40                  45               
 
 
Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala  
    50                  55                  60                   
 
 
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr  
65                  70                  75                  80   
 
 
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr  
                85                  90                  95       
 
 
Tyr Cys Thr Arg Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly  
            100                 105                 110          
 
 
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser  
        115                 120                 125              
 
 
Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala  
    130                 135                 140                  
 
 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val  
145                 150                 155                 160  
 
 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala  
                165                 170                 175      
 
 
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val  
            180                 185                 190          
 
 
Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His  
        195                 200                 205              
 
 
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly  
    210                 215                 220                  
 
 
Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser  
225                 230                 235                 240  
 
 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg  
                245                 250                 255      
 
 
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro  
            260                 265                 270          
 
 
Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala  
        275                 280                 285              
 
 
Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val  
    290                 295                 300                  
 
 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr  
305                 310                 315                 320  
 
 
Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr  
                325                 330                 335      
 
 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu  
            340                 345                 350          
 
 
Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys  
        355                 360                 365              
 
 
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser  
    370                 375                 380                  
 
 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp  
385                 390                 395                 400  
 
 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser  
                405                 410                 415      
 
 
Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala  
            420                 425                 430          
 
 
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys  
        435                 440                 445              
 
 
<210>  194 
<211>  218 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  mAb 0170 VL 
 
<400>  194 
 
Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly  
1               5                   10                  15       
 
 
Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Asp Thr Phe  
            20                  25                  30           
 
 
Asp Tyr Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro  
        35                  40                  45               
 
 
Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp  
    50                  55                  60                   
 
 
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser  
65                  70                  75                  80   
 
 
Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn  
                85                  90                  95       
 
 
Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg  
            100                 105                 110          
 
 
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln  
        115                 120                 125              
 
 
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr  
    130                 135                 140                  
 
 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser  
145                 150                 155                 160  
 
 
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr  
                165                 170                 175      
 
 
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys  
            180                 185                 190          
 
 
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro  
        195                 200                 205              
 
 
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys  
    210                 215              
 
 
<210>  195 
<211>  321 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047289 VL 
 
<400>  195 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgtcaacag tttaatagtt accctctcac tttcggcgga      300 
 
gggaccaagg tggagatcaa a                                                321 
 
 
<210>  196 
<211>  321 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047299 VL 
 
<400>  196 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgtggac gttcggccaa      300 
 
gggaccaagg tggaaatcaa a                                                321 
 
 
<210>  197 
<211>  454 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047239 Heavy Chain 
 
<400>  197 
 
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg  
1               5                   10                  15       
 
 
Ser Leu Arg Leu Ser Cys Ala Ala Thr Glu Phe Thr Phe Ser Asn Tyr  
            20                  25                  30           
 
 
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val  
        35                  40                  45               
 
 
Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val  
    50                  55                  60                   
 
 
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr  
65                  70                  75                  80   
 
 
Leu Gln Leu Asn Ser Leu Ser Ala Glu Asp Ser Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Asp Gly Arg His Tyr Tyr Gly Ser Thr Ser Tyr Phe Gly Met  
            100                 105                 110          
 
 
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr  
        115                 120                 125              
 
 
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser  
    130                 135                 140                  
 
 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu  
145                 150                 155                 160  
 
 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His  
                165                 170                 175      
 
 
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser  
            180                 185                 190          
 
 
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys  
        195                 200                 205              
 
 
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu  
    210                 215                 220                  
 
 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro  
225                 230                 235                 240  
 
 
Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys  
                245                 250                 255      
 
 
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val  
            260                 265                 270          
 
 
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp  
        275                 280                 285              
 
 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr  
    290                 295                 300                  
 
 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp  
305                 310                 315                 320  
 
 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu  
                325                 330                 335      
 
 
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg  
            340                 345                 350          
 
 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys  
        355                 360                 365              
 
 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp  
    370                 375                 380                  
 
 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys  
385                 390                 395                 400  
 
 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser  
                405                 410                 415      
 
 
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser  
            420                 425                 430          
 
 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser  
        435                 440                 445              
 
 
Leu Ser Leu Ser Pro Gly  
    450                  
 
 
<210>  198 
<211>  451 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047246 Heavy Chain 
 
<400>  198 
 
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu  
1               5                   10                  15       
 
 
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Asn Tyr  
            20                  25                  30           
 
 
Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile  
        35                  40                  45               
 
 
Gly Tyr Ile Tyr Asp Ser Gly Tyr Thr Asn Tyr Asn Pro Ser Leu Lys  
    50                  55                  60                   
 
 
Ser Arg Val Thr Leu Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu  
65                  70                  75                  80   
 
 
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala  
                85                  90                  95       
 
 
Arg Gly Val Leu Trp Phe Gly Glu Leu Leu Pro Leu Leu Asp Tyr Trp  
            100                 105                 110          
 
 
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro  
        115                 120                 125              
 
 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr  
    130                 135                 140                  
 
 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr  
145                 150                 155                 160  
 
 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro  
                165                 170                 175      
 
 
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr  
            180                 185                 190          
 
 
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn  
        195                 200                 205              
 
 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser  
    210                 215                 220                  
 
 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu  
225                 230                 235                 240  
 
 
Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu  
                245                 250                 255      
 
 
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser  
            260                 265                 270          
 
 
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu  
        275                 280                 285              
 
 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr  
    290                 295                 300                  
 
 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn  
305                 310                 315                 320  
 
 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser  
                325                 330                 335      
 
 
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln  
            340                 345                 350          
 
 
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val  
        355                 360                 365              
 
 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val  
    370                 375                 380                  
 
 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro  
385                 390                 395                 400  
 
 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr  
                405                 410                 415      
 
 
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val  
            420                 425                 430          
 
 
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu  
        435                 440                 445              
 
 
Ser Pro Gly  
    450      
 
 
<210>  199 
<211>  451 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047247 Heavy Chain 
 
<400>  199 
 
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu  
1               5                   10                  15       
 
 
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Asn Tyr  
            20                  25                  30           
 
 
Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile  
        35                  40                  45               
 
 
Gly Tyr Ile Tyr Asp Ser Gly Tyr Thr Asn Tyr Asn Pro Ser Leu Lys  
    50                  55                  60                   
 
 
Ser Arg Val Thr Leu Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu  
65                  70                  75                  80   
 
 
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala  
                85                  90                  95       
 
 
Arg Gly Val Leu Trp Phe Gly Glu Leu Leu Pro Leu Leu Asp Tyr Trp  
            100                 105                 110          
 
 
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro  
        115                 120                 125              
 
 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr  
    130                 135                 140                  
 
 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr  
145                 150                 155                 160  
 
 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro  
                165                 170                 175      
 
 
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr  
            180                 185                 190          
 
 
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn  
        195                 200                 205              
 
 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser  
    210                 215                 220                  
 
 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu  
225                 230                 235                 240  
 
 
Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu  
                245                 250                 255      
 
 
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser  
            260                 265                 270          
 
 
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu  
        275                 280                 285              
 
 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr  
    290                 295                 300                  
 
 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn  
305                 310                 315                 320  
 
 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser  
                325                 330                 335      
 
 
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln  
            340                 345                 350          
 
 
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val  
        355                 360                 365              
 
 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val  
    370                 375                 380                  
 
 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro  
385                 390                 395                 400  
 
 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr  
                405                 410                 415      
 
 
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val  
            420                 425                 430          
 
 
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu  
        435                 440                 445              
 
 
Ser Pro Gly  
    450      
 
 
<210>  200 
<211>  453 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047248 Heavy Chain 
 
<400>  200 
 
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu  
1               5                   10                  15       
 
 
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser  
            20                  25                  30           
 
 
Tyr Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile  
        35                  40                  45               
 
 
Gly Tyr Thr His Tyr Ser Gly Ile Ser Asn Tyr Asn Pro Ser Leu Lys  
    50                  55                  60                   
 
 
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu  
65                  70                  75                  80   
 
 
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala  
                85                  90                  95       
 
 
Arg Glu Gly Tyr Asp Ile Leu Thr Gly Tyr Glu Tyr Tyr Gly Met Asp  
            100                 105                 110          
 
 
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys  
        115                 120                 125              
 
 
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly  
    130                 135                 140                  
 
 
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro  
145                 150                 155                 160  
 
 
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr  
                165                 170                 175      
 
 
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val  
            180                 185                 190          
 
 
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn  
        195                 200                 205              
 
 
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro  
    210                 215                 220                  
 
 
Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu  
225                 230                 235                 240  
 
 
Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp  
                245                 250                 255      
 
 
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp  
            260                 265                 270          
 
 
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly  
        275                 280                 285              
 
 
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn  
    290                 295                 300                  
 
 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp  
305                 310                 315                 320  
 
 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro  
                325                 330                 335      
 
 
Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu  
            340                 345                 350          
 
 
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn  
        355                 360                 365              
 
 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile  
    370                 375                 380                  
 
 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr  
385                 390                 395                 400  
 
 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys  
                405                 410                 415      
 
 
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys  
            420                 425                 430          
 
 
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu  
        435                 440                 445              
 
 
Ser Leu Ser Pro Gly  
    450              
 
 
<210>  201 
<211>  455 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047323 Heavy Chain 
 
<400>  201 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ile Asn Ser  
            20                  25                  30           
 
 
Glu Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp  
        35                  40                  45               
 
 
Met Gly Gly Ile Ile Pro Ile Phe Asp Ile Thr Asn Tyr Ala Gln Lys  
    50                  55                  60                   
 
 
Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Met Ser Thr Ala  
65                  70                  75                  80   
 
 
Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr  
                85                  90                  95       
 
 
Cys Ala Lys Thr Tyr Tyr Asp Ile Leu Thr Tyr His Tyr His Tyr Gly  
            100                 105                 110          
 
 
Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser  
        115                 120                 125              
 
 
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr  
    130                 135                 140                  
 
 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro  
145                 150                 155                 160  
 
 
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val  
                165                 170                 175      
 
 
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser  
            180                 185                 190          
 
 
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile  
        195                 200                 205              
 
 
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val  
    210                 215                 220                  
 
 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala  
225                 230                 235                 240  
 
 
Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro  
                245                 250                 255      
 
 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val  
            260                 265                 270          
 
 
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val  
        275                 280                 285              
 
 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln  
    290                 295                 300                  
 
 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln  
305                 310                 315                 320  
 
 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala  
                325                 330                 335      
 
 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro  
            340                 345                 350          
 
 
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr  
        355                 360                 365              
 
 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser  
    370                 375                 380                  
 
 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr  
385                 390                 395                 400  
 
 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr  
                405                 410                 415      
 
 
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe  
            420                 425                 430          
 
 
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys  
        435                 440                 445              
 
 
Ser Leu Ser Leu Ser Pro Gly  
    450                 455  
 
 
<210>  202 
<211>  455 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047328 Heavy Chain 
 
<400>  202 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ile Asn Ser  
            20                  25                  30           
 
 
Glu Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp  
        35                  40                  45               
 
 
Met Gly Gly Ile Ile Pro Ile Phe Asp Ile Thr Asn Tyr Ala Gln Lys  
    50                  55                  60                   
 
 
Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Met Ser Thr Ala  
65                  70                  75                  80   
 
 
Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr  
                85                  90                  95       
 
 
Cys Ala Lys Thr Tyr Tyr Asp Ile Leu Thr Tyr His Tyr His Tyr Gly  
            100                 105                 110          
 
 
Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser  
        115                 120                 125              
 
 
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr  
    130                 135                 140                  
 
 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro  
145                 150                 155                 160  
 
 
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val  
                165                 170                 175      
 
 
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser  
            180                 185                 190          
 
 
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile  
        195                 200                 205              
 
 
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val  
    210                 215                 220                  
 
 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala  
225                 230                 235                 240  
 
 
Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro  
                245                 250                 255      
 
 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val  
            260                 265                 270          
 
 
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val  
        275                 280                 285              
 
 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln  
    290                 295                 300                  
 
 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln  
305                 310                 315                 320  
 
 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala  
                325                 330                 335      
 
 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro  
            340                 345                 350          
 
 
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr  
        355                 360                 365              
 
 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser  
    370                 375                 380                  
 
 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr  
385                 390                 395                 400  
 
 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr  
                405                 410                 415      
 
 
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe  
            420                 425                 430          
 
 
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys  
        435                 440                 445              
 
 
Ser Leu Ser Leu Ser Pro Gly  
    450                 455  
 
 
<210>  203 
<211>  452 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047334 Heavy Chain 
 
<400>  203 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Ser  
            20                  25                  30           
 
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Gly Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Ala Met Val Arg Gly Asn Tyr Phe Tyr Phe Tyr Gly Met Asp Val  
            100                 105                 110          
 
 
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly  
        115                 120                 125              
 
 
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly  
    130                 135                 140                  
 
 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val  
145                 150                 155                 160  
 
 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe  
                165                 170                 175      
 
 
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val  
            180                 185                 190          
 
 
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val  
        195                 200                 205              
 
 
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys  
    210                 215                 220                  
 
 
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala  
225                 230                 235                 240  
 
 
Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr  
                245                 250                 255      
 
 
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val  
            260                 265                 270          
 
 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val  
        275                 280                 285              
 
 
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser  
    290                 295                 300                  
 
 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu  
305                 310                 315                 320  
 
 
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser  
                325                 330                 335      
 
 
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro  
            340                 345                 350          
 
 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln  
        355                 360                 365              
 
 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala  
    370                 375                 380                  
 
 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr  
385                 390                 395                 400  
 
 
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu  
                405                 410                 415      
 
 
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser  
            420                 425                 430          
 
 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser  
        435                 440                 445              
 
 
Leu Ser Pro Gly  
    450          
 
 
<210>  204 
<211>  455 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047263 Heavy Chain 
 
<400>  204 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Pro Thr Tyr  
            20                  25                  30           
 
 
Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Trp Val Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Asp Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Ser Asp Gly Leu Asn Met Val Arg Gly Val His Asn Tyr Tyr Gly  
            100                 105                 110          
 
 
Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser  
        115                 120                 125              
 
 
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr  
    130                 135                 140                  
 
 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro  
145                 150                 155                 160  
 
 
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val  
                165                 170                 175      
 
 
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser  
            180                 185                 190          
 
 
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile  
        195                 200                 205              
 
 
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val  
    210                 215                 220                  
 
 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala  
225                 230                 235                 240  
 
 
Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro  
                245                 250                 255      
 
 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val  
            260                 265                 270          
 
 
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val  
        275                 280                 285              
 
 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln  
    290                 295                 300                  
 
 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln  
305                 310                 315                 320  
 
 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala  
                325                 330                 335      
 
 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro  
            340                 345                 350          
 
 
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr  
        355                 360                 365              
 
 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser  
    370                 375                 380                  
 
 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr  
385                 390                 395                 400  
 
 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr  
                405                 410                 415      
 
 
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe  
            420                 425                 430          
 
 
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys  
        435                 440                 445              
 
 
Ser Leu Ser Leu Ser Pro Gly  
    450                 455  
 
 
<210>  205 
<211>  455 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047265 Heavy Chain 
 
<400>  205 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Pro Thr Tyr  
            20                  25                  30           
 
 
Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Trp Val Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Asp Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Ser Asp Gly Leu Asn Met Val Arg Gly Val His Asn Tyr Tyr Gly  
            100                 105                 110          
 
 
Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser  
        115                 120                 125              
 
 
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr  
    130                 135                 140                  
 
 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro  
145                 150                 155                 160  
 
 
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val  
                165                 170                 175      
 
 
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser  
            180                 185                 190          
 
 
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile  
        195                 200                 205              
 
 
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val  
    210                 215                 220                  
 
 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala  
225                 230                 235                 240  
 
 
Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro  
                245                 250                 255      
 
 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val  
            260                 265                 270          
 
 
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val  
        275                 280                 285              
 
 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln  
    290                 295                 300                  
 
 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln  
305                 310                 315                 320  
 
 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala  
                325                 330                 335      
 
 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro  
            340                 345                 350          
 
 
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr  
        355                 360                 365              
 
 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser  
    370                 375                 380                  
 
 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr  
385                 390                 395                 400  
 
 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr  
                405                 410                 415      
 
 
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe  
            420                 425                 430          
 
 
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys  
        435                 440                 445              
 
 
Ser Leu Ser Leu Ser Pro Gly  
    450                 455  
 
 
<210>  206 
<211>  455 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047289 Heavy Chain 
 
<400>  206 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Ser  
            20                  25                  30           
 
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asp Ser Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Phe Thr Pro Arg Tyr Arg Gly Ser Ser His His Tyr Phe Tyr Ala  
            100                 105                 110          
 
 
Leu Gly Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser  
        115                 120                 125              
 
 
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr  
    130                 135                 140                  
 
 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro  
145                 150                 155                 160  
 
 
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val  
                165                 170                 175      
 
 
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser  
            180                 185                 190          
 
 
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile  
        195                 200                 205              
 
 
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val  
    210                 215                 220                  
 
 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala  
225                 230                 235                 240  
 
 
Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro  
                245                 250                 255      
 
 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val  
            260                 265                 270          
 
 
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val  
        275                 280                 285              
 
 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln  
    290                 295                 300                  
 
 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln  
305                 310                 315                 320  
 
 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala  
                325                 330                 335      
 
 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro  
            340                 345                 350          
 
 
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr  
        355                 360                 365              
 
 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser  
    370                 375                 380                  
 
 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr  
385                 390                 395                 400  
 
 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr  
                405                 410                 415      
 
 
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe  
            420                 425                 430          
 
 
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys  
        435                 440                 445              
 
 
Ser Leu Ser Leu Ser Pro Gly  
    450                 455  
 
 
<210>  207 
<211>  456 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047290 Heavy Chain 
 
<400>  207 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg His  
            20                  25                  30           
 
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Ala Ala Asp Glu Pro Thr Ser Thr Thr Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Ser Ser Tyr Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr  
            100                 105                 110          
 
 
Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala  
        115                 120                 125              
 
 
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser  
    130                 135                 140                  
 
 
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe  
145                 150                 155                 160  
 
 
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly  
                165                 170                 175      
 
 
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu  
            180                 185                 190          
 
 
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr  
        195                 200                 205              
 
 
Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg  
    210                 215                 220                  
 
 
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro  
225                 230                 235                 240  
 
 
Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys  
                245                 250                 255      
 
 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val  
            260                 265                 270          
 
 
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr  
        275                 280                 285              
 
 
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu  
    290                 295                 300                  
 
 
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His  
305                 310                 315                 320  
 
 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys  
                325                 330                 335      
 
 
Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln  
            340                 345                 350          
 
 
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met  
        355                 360                 365              
 
 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro  
    370                 375                 380                  
 
 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn  
385                 390                 395                 400  
 
 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu  
                405                 410                 415      
 
 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val  
            420                 425                 430          
 
 
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln  
        435                 440                 445              
 
 
Lys Ser Leu Ser Leu Ser Pro Gly  
    450                 455      
 
 
<210>  208 
 
<400>  208 
000 
 
<210>  209 
<211>  456 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047291 Heavy Chain 
 
<400>  209 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg His  
            20                  25                  30           
 
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Ala Ala Asp Glu Pro Thr Ser Thr Thr Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Ser Ser Tyr Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr  
            100                 105                 110          
 
 
Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala  
        115                 120                 125              
 
 
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser  
    130                 135                 140                  
 
 
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe  
145                 150                 155                 160  
 
 
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly  
                165                 170                 175      
 
 
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu  
            180                 185                 190          
 
 
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr  
        195                 200                 205              
 
 
Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg  
    210                 215                 220                  
 
 
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro  
225                 230                 235                 240  
 
 
Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys  
                245                 250                 255      
 
 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val  
            260                 265                 270          
 
 
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr  
        275                 280                 285              
 
 
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu  
    290                 295                 300                  
 
 
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His  
305                 310                 315                 320  
 
 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys  
                325                 330                 335      
 
 
Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln  
            340                 345                 350          
 
 
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met  
        355                 360                 365              
 
 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro  
    370                 375                 380                  
 
 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn  
385                 390                 395                 400  
 
 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu  
                405                 410                 415      
 
 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val  
            420                 425                 430          
 
 
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln  
        435                 440                 445              
 
 
Lys Ser Leu Ser Leu Ser Pro Gly  
    450                 455      
 
 
<210>  210 
<211>  455 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047292 Heavy Chain 
 
<400>  210 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Ser  
            20                  25                  30           
 
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Ile Phe Ser Thr Gly Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Asp Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Ser Thr Arg Val Arg Gly Val Ser His Tyr Tyr Tyr Tyr Gly  
            100                 105                 110          
 
 
Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser  
        115                 120                 125              
 
 
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr  
    130                 135                 140                  
 
 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro  
145                 150                 155                 160  
 
 
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val  
                165                 170                 175      
 
 
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser  
            180                 185                 190          
 
 
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile  
        195                 200                 205              
 
 
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val  
    210                 215                 220                  
 
 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala  
225                 230                 235                 240  
 
 
Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro  
                245                 250                 255      
 
 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val  
            260                 265                 270          
 
 
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val  
        275                 280                 285              
 
 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln  
    290                 295                 300                  
 
 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln  
305                 310                 315                 320  
 
 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala  
                325                 330                 335      
 
 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro  
            340                 345                 350          
 
 
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr  
        355                 360                 365              
 
 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser  
    370                 375                 380                  
 
 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr  
385                 390                 395                 400  
 
 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr  
                405                 410                 415      
 
 
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe  
            420                 425                 430          
 
 
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys  
        435                 440                 445              
 
 
Ser Leu Ser Leu Ser Pro Gly  
    450                 455  
 
 
<210>  211 
<211>  456 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047294 Heavy Chain 
 
<400>  211 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg His  
            20                  25                  30           
 
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Glu Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Ala Ala Asp Glu Pro Thr Ser Thr Thr Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Ser Ser Tyr Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr  
            100                 105                 110          
 
 
Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala  
        115                 120                 125              
 
 
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser  
    130                 135                 140                  
 
 
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe  
145                 150                 155                 160  
 
 
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly  
                165                 170                 175      
 
 
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu  
            180                 185                 190          
 
 
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr  
        195                 200                 205              
 
 
Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg  
    210                 215                 220                  
 
 
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro  
225                 230                 235                 240  
 
 
Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys  
                245                 250                 255      
 
 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val  
            260                 265                 270          
 
 
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr  
        275                 280                 285              
 
 
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu  
    290                 295                 300                  
 
 
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His  
305                 310                 315                 320  
 
 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys  
                325                 330                 335      
 
 
Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln  
            340                 345                 350          
 
 
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met  
        355                 360                 365              
 
 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro  
    370                 375                 380                  
 
 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn  
385                 390                 395                 400  
 
 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu  
                405                 410                 415      
 
 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val  
            420                 425                 430          
 
 
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln  
        435                 440                 445              
 
 
Lys Ser Leu Ser Leu Ser Pro Gly  
    450                 455      
 
 
<210>  212 
<211>  456 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047296 Heavy Chain 
 
<400>  212 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg His  
            20                  25                  30           
 
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Ala Ala Asp Glu Pro Thr Ser Thr Thr Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Ser Ser Tyr Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr  
            100                 105                 110          
 
 
Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala  
        115                 120                 125              
 
 
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser  
    130                 135                 140                  
 
 
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe  
145                 150                 155                 160  
 
 
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly  
                165                 170                 175      
 
 
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu  
            180                 185                 190          
 
 
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr  
        195                 200                 205              
 
 
Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg  
    210                 215                 220                  
 
 
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro  
225                 230                 235                 240  
 
 
Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys  
                245                 250                 255      
 
 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val  
            260                 265                 270          
 
 
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr  
        275                 280                 285              
 
 
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu  
    290                 295                 300                  
 
 
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His  
305                 310                 315                 320  
 
 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys  
                325                 330                 335      
 
 
Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln  
            340                 345                 350          
 
 
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met  
        355                 360                 365              
 
 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro  
    370                 375                 380                  
 
 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn  
385                 390                 395                 400  
 
 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu  
                405                 410                 415      
 
 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val  
            420                 425                 430          
 
 
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln  
        435                 440                 445              
 
 
Lys Ser Leu Ser Leu Ser Pro Gly  
    450                 455      
 
 
<210>  213 
<211>  456 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047297 Heavy Chain 
 
<400>  213 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg His  
            20                  25                  30           
 
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Ala Ala Asp Glu Pro Thr Ser Thr Thr Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Ser Ser Tyr Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr  
            100                 105                 110          
 
 
Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala  
        115                 120                 125              
 
 
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser  
    130                 135                 140                  
 
 
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe  
145                 150                 155                 160  
 
 
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly  
                165                 170                 175      
 
 
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu  
            180                 185                 190          
 
 
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr  
        195                 200                 205              
 
 
Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg  
    210                 215                 220                  
 
 
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro  
225                 230                 235                 240  
 
 
Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys  
                245                 250                 255      
 
 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val  
            260                 265                 270          
 
 
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr  
        275                 280                 285              
 
 
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu  
    290                 295                 300                  
 
 
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His  
305                 310                 315                 320  
 
 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys  
                325                 330                 335      
 
 
Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln  
            340                 345                 350          
 
 
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met  
        355                 360                 365              
 
 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro  
    370                 375                 380                  
 
 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn  
385                 390                 395                 400  
 
 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu  
                405                 410                 415      
 
 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val  
            420                 425                 430          
 
 
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln  
        435                 440                 445              
 
 
Lys Ser Leu Ser Leu Ser Pro Gly  
    450                 455      
 
 
<210>  214 
<211>  456 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047299 Heavy Chain 
 
<400>  214 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg Tyr  
            20                  25                  30           
 
 
Ala Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Ile Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Ser Ser His Phe Tyr Gly Ser Gly Ser Ser His Phe Tyr Tyr Tyr  
            100                 105                 110          
 
 
Gly Met His Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala  
        115                 120                 125              
 
 
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser  
    130                 135                 140                  
 
 
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe  
145                 150                 155                 160  
 
 
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly  
                165                 170                 175      
 
 
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu  
            180                 185                 190          
 
 
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr  
        195                 200                 205              
 
 
Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg  
    210                 215                 220                  
 
 
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro  
225                 230                 235                 240  
 
 
Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys  
                245                 250                 255      
 
 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val  
            260                 265                 270          
 
 
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr  
        275                 280                 285              
 
 
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu  
    290                 295                 300                  
 
 
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His  
305                 310                 315                 320  
 
 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys  
                325                 330                 335      
 
 
Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln  
            340                 345                 350          
 
 
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met  
        355                 360                 365              
 
 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro  
    370                 375                 380                  
 
 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn  
385                 390                 395                 400  
 
 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu  
                405                 410                 415      
 
 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val  
            420                 425                 430          
 
 
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln  
        435                 440                 445              
 
 
Lys Ser Leu Ser Leu Ser Pro Gly  
    450                 455      
 
 
<210>  215 
<211>  456 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047300 Heavy Chain 
 
<400>  215 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg His  
            20                  25                  30           
 
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Ala Ala Asp Glu Pro Thr Ser Thr Thr Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Ser Ser Tyr Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr  
            100                 105                 110          
 
 
Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala  
        115                 120                 125              
 
 
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser  
    130                 135                 140                  
 
 
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe  
145                 150                 155                 160  
 
 
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly  
                165                 170                 175      
 
 
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu  
            180                 185                 190          
 
 
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr  
        195                 200                 205              
 
 
Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg  
    210                 215                 220                  
 
 
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro  
225                 230                 235                 240  
 
 
Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys  
                245                 250                 255      
 
 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val  
            260                 265                 270          
 
 
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr  
        275                 280                 285              
 
 
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu  
    290                 295                 300                  
 
 
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His  
305                 310                 315                 320  
 
 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys  
                325                 330                 335      
 
 
Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln  
            340                 345                 350          
 
 
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met  
        355                 360                 365              
 
 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro  
    370                 375                 380                  
 
 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn  
385                 390                 395                 400  
 
 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu  
                405                 410                 415      
 
 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val  
            420                 425                 430          
 
 
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln  
        435                 440                 445              
 
 
Lys Ser Leu Ser Leu Ser Pro Gly  
    450                 455      
 
 
<210>  216 
<211>  456 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047301 Heavy Chain 
 
<400>  216 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg Tyr  
            20                  25                  30           
 
 
Ala Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Ile Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Ser Ser His Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr  
            100                 105                 110          
 
 
Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala  
        115                 120                 125              
 
 
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser  
    130                 135                 140                  
 
 
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe  
145                 150                 155                 160  
 
 
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly  
                165                 170                 175      
 
 
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu  
            180                 185                 190          
 
 
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr  
        195                 200                 205              
 
 
Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg  
    210                 215                 220                  
 
 
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro  
225                 230                 235                 240  
 
 
Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys  
                245                 250                 255      
 
 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val  
            260                 265                 270          
 
 
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr  
        275                 280                 285              
 
 
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu  
    290                 295                 300                  
 
 
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His  
305                 310                 315                 320  
 
 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys  
                325                 330                 335      
 
 
Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln  
            340                 345                 350          
 
 
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met  
        355                 360                 365              
 
 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro  
    370                 375                 380                  
 
 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn  
385                 390                 395                 400  
 
 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu  
                405                 410                 415      
 
 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val  
            420                 425                 430          
 
 
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln  
        435                 440                 445              
 
 
Lys Ser Leu Ser Leu Ser Pro Gly  
    450                 455      
 
 
<210>  217 
<211>  456 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047302 Heavy Chain 
 
<400>  217 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg His  
            20                  25                  30           
 
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Ala Ala Asp Glu Pro Thr Ser Thr Thr Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Ser Ser Tyr Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr  
            100                 105                 110          
 
 
Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala  
        115                 120                 125              
 
 
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser  
    130                 135                 140                  
 
 
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe  
145                 150                 155                 160  
 
 
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly  
                165                 170                 175      
 
 
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu  
            180                 185                 190          
 
 
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr  
        195                 200                 205              
 
 
Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg  
    210                 215                 220                  
 
 
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro  
225                 230                 235                 240  
 
 
Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys  
                245                 250                 255      
 
 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val  
            260                 265                 270          
 
 
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr  
        275                 280                 285              
 
 
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu  
    290                 295                 300                  
 
 
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His  
305                 310                 315                 320  
 
 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys  
                325                 330                 335      
 
 
Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln  
            340                 345                 350          
 
 
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met  
        355                 360                 365              
 
 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro  
    370                 375                 380                  
 
 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn  
385                 390                 395                 400  
 
 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu  
                405                 410                 415      
 
 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val  
            420                 425                 430          
 
 
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln  
        435                 440                 445              
 
 
Lys Ser Leu Ser Leu Ser Pro Gly  
    450                 455      
 
 
<210>  218 
<211>  455 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047305 Heavy Chain 
 
<400>  218 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Thr Ser Gly Gly Thr Phe Ser Ser Ser  
            20                  25                  30           
 
 
Ala Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Thr Pro Ile Phe Gly Thr Ala Asp Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Ala Ser Thr Ser Thr Gly Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Phe Thr Pro Arg Tyr Arg Gly Ser Ser His His Tyr Tyr Tyr Ala  
            100                 105                 110          
 
 
Leu Gly Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser  
        115                 120                 125              
 
 
Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr  
    130                 135                 140                  
 
 
Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro  
145                 150                 155                 160  
 
 
Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val  
                165                 170                 175      
 
 
His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser  
            180                 185                 190          
 
 
Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile  
        195                 200                 205              
 
 
Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val  
    210                 215                 220                  
 
 
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala  
225                 230                 235                 240  
 
 
Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro  
                245                 250                 255      
 
 
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val  
            260                 265                 270          
 
 
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val  
        275                 280                 285              
 
 
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln  
    290                 295                 300                  
 
 
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln  
305                 310                 315                 320  
 
 
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala  
                325                 330                 335      
 
 
Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro  
            340                 345                 350          
 
 
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr  
        355                 360                 365              
 
 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser  
    370                 375                 380                  
 
 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr  
385                 390                 395                 400  
 
 
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr  
                405                 410                 415      
 
 
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe  
            420                 425                 430          
 
 
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys  
        435                 440                 445              
 
 
Ser Leu Ser Leu Ser Pro Gly  
    450                 455  
 
 
<210>  219 
<211>  454 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047306 Heavy Chain 
 
<400>  219 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Ser  
            20                  25                  30           
 
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Ala Ser Gln Ser Arg Ser Ser Asn Tyr Tyr Tyr Tyr Gly Leu  
            100                 105                 110          
 
 
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr  
        115                 120                 125              
 
 
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser  
    130                 135                 140                  
 
 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu  
145                 150                 155                 160  
 
 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His  
                165                 170                 175      
 
 
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser  
            180                 185                 190          
 
 
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys  
        195                 200                 205              
 
 
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu  
    210                 215                 220                  
 
 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro  
225                 230                 235                 240  
 
 
Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys  
                245                 250                 255      
 
 
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val  
            260                 265                 270          
 
 
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp  
        275                 280                 285              
 
 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr  
    290                 295                 300                  
 
 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp  
305                 310                 315                 320  
 
 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu  
                325                 330                 335      
 
 
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg  
            340                 345                 350          
 
 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys  
        355                 360                 365              
 
 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp  
    370                 375                 380                  
 
 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys  
385                 390                 395                 400  
 
 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser  
                405                 410                 415      
 
 
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser  
            420                 425                 430          
 
 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser  
        435                 440                 445              
 
 
Leu Ser Leu Ser Pro Gly  
    450                  
 
 
<210>  220 
<211>  454 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047307 Heavy Chain 
 
<400>  220 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr  
            20                  25                  30           
 
 
Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Gln Phe  
    50                  55                  60                   
 
 
Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu  
            100                 105                 110          
 
 
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr  
        115                 120                 125              
 
 
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser  
    130                 135                 140                  
 
 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu  
145                 150                 155                 160  
 
 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His  
                165                 170                 175      
 
 
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser  
            180                 185                 190          
 
 
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys  
        195                 200                 205              
 
 
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu  
    210                 215                 220                  
 
 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro  
225                 230                 235                 240  
 
 
Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys  
                245                 250                 255      
 
 
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val  
            260                 265                 270          
 
 
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp  
        275                 280                 285              
 
 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr  
    290                 295                 300                  
 
 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp  
305                 310                 315                 320  
 
 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu  
                325                 330                 335      
 
 
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg  
            340                 345                 350          
 
 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys  
        355                 360                 365              
 
 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp  
    370                 375                 380                  
 
 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys  
385                 390                 395                 400  
 
 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser  
                405                 410                 415      
 
 
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser  
            420                 425                 430          
 
 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser  
        435                 440                 445              
 
 
Leu Ser Leu Ser Pro Gly  
    450                  
 
 
<210>  221 
<211>  454 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047308 Heavy Chain 
 
<400>  221 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr  
            20                  25                  30           
 
 
Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu  
            100                 105                 110          
 
 
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr  
        115                 120                 125              
 
 
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser  
    130                 135                 140                  
 
 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu  
145                 150                 155                 160  
 
 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His  
                165                 170                 175      
 
 
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser  
            180                 185                 190          
 
 
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys  
        195                 200                 205              
 
 
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu  
    210                 215                 220                  
 
 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro  
225                 230                 235                 240  
 
 
Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys  
                245                 250                 255      
 
 
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val  
            260                 265                 270          
 
 
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp  
        275                 280                 285              
 
 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr  
    290                 295                 300                  
 
 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp  
305                 310                 315                 320  
 
 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu  
                325                 330                 335      
 
 
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg  
            340                 345                 350          
 
 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys  
        355                 360                 365              
 
 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp  
    370                 375                 380                  
 
 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys  
385                 390                 395                 400  
 
 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser  
                405                 410                 415      
 
 
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser  
            420                 425                 430          
 
 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser  
        435                 440                 445              
 
 
Leu Ser Leu Ser Pro Gly  
    450                  
 
 
<210>  222 
<211>  446 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047309 Heavy Chain 
 
<400>  222 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Asn Pro Ser Gly Gly Thr Phe Ser Thr Tyr  
            20                  25                  30           
 
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Asn Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Pro Gly Tyr  
65                  70                  75                  80   
 
 
Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Gly Gly Ala Val Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu  
            100                 105                 110          
 
 
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu  
        115                 120                 125              
 
 
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys  
    130                 135                 140                  
 
 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser  
145                 150                 155                 160  
 
 
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser  
                165                 170                 175      
 
 
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser  
            180                 185                 190          
 
 
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn  
        195                 200                 205              
 
 
Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His  
    210                 215                 220                  
 
 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val  
225                 230                 235                 240  
 
 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr  
                245                 250                 255      
 
 
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu  
            260                 265                 270          
 
 
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys  
        275                 280                 285              
 
 
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser  
    290                 295                 300                  
 
 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys  
305                 310                 315                 320  
 
 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile  
                325                 330                 335      
 
 
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro  
            340                 345                 350          
 
 
Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu  
        355                 360                 365              
 
 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn  
    370                 375                 380                  
 
 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser  
385                 390                 395                 400  
 
 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg  
                405                 410                 415      
 
 
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu  
            420                 425                 430          
 
 
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly  
        435                 440                 445      
 
 
<210>  223 
<211>  454 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047310 Heavy Chain 
 
<400>  223 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Arg Tyr  
            20                  25                  30           
 
 
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Ile Phe Gly Thr Ser Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Lys Ala Asp Glu Ser Thr Ser Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Gly Gly Asn Ser Trp Thr Thr Ser Leu Tyr Tyr Tyr Gly Met  
            100                 105                 110          
 
 
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr  
        115                 120                 125              
 
 
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser  
    130                 135                 140                  
 
 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu  
145                 150                 155                 160  
 
 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His  
                165                 170                 175      
 
 
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser  
            180                 185                 190          
 
 
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys  
        195                 200                 205              
 
 
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu  
    210                 215                 220                  
 
 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro  
225                 230                 235                 240  
 
 
Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys  
                245                 250                 255      
 
 
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val  
            260                 265                 270          
 
 
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp  
        275                 280                 285              
 
 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr  
    290                 295                 300                  
 
 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp  
305                 310                 315                 320  
 
 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu  
                325                 330                 335      
 
 
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg  
            340                 345                 350          
 
 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys  
        355                 360                 365              
 
 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp  
    370                 375                 380                  
 
 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys  
385                 390                 395                 400  
 
 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser  
                405                 410                 415      
 
 
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser  
            420                 425                 430          
 
 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser  
        435                 440                 445              
 
 
Leu Ser Leu Ser Pro Gly  
    450                  
 
 
<210>  224 
<211>  454 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047311 Heavy Chain 
 
<400>  224 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr  
            20                  25                  30           
 
 
Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Gln Phe  
    50                  55                  60                   
 
 
Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu  
            100                 105                 110          
 
 
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr  
        115                 120                 125              
 
 
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser  
    130                 135                 140                  
 
 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu  
145                 150                 155                 160  
 
 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His  
                165                 170                 175      
 
 
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser  
            180                 185                 190          
 
 
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys  
        195                 200                 205              
 
 
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu  
    210                 215                 220                  
 
 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro  
225                 230                 235                 240  
 
 
Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys  
                245                 250                 255      
 
 
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val  
            260                 265                 270          
 
 
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp  
        275                 280                 285              
 
 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr  
    290                 295                 300                  
 
 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp  
305                 310                 315                 320  
 
 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu  
                325                 330                 335      
 
 
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg  
            340                 345                 350          
 
 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys  
        355                 360                 365              
 
 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp  
    370                 375                 380                  
 
 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys  
385                 390                 395                 400  
 
 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser  
                405                 410                 415      
 
 
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser  
            420                 425                 430          
 
 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser  
        435                 440                 445              
 
 
Leu Ser Leu Ser Pro Gly  
    450                  
 
 
<210>  225 
<211>  454 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047312 Heavy Chain 
 
<400>  225 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr  
            20                  25                  30           
 
 
Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Gln Phe  
    50                  55                  60                   
 
 
Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu  
            100                 105                 110          
 
 
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr  
        115                 120                 125              
 
 
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser  
    130                 135                 140                  
 
 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu  
145                 150                 155                 160  
 
 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His  
                165                 170                 175      
 
 
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser  
            180                 185                 190          
 
 
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys  
        195                 200                 205              
 
 
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu  
    210                 215                 220                  
 
 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro  
225                 230                 235                 240  
 
 
Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys  
                245                 250                 255      
 
 
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val  
            260                 265                 270          
 
 
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp  
        275                 280                 285              
 
 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr  
    290                 295                 300                  
 
 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp  
305                 310                 315                 320  
 
 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu  
                325                 330                 335      
 
 
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg  
            340                 345                 350          
 
 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys  
        355                 360                 365              
 
 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp  
    370                 375                 380                  
 
 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys  
385                 390                 395                 400  
 
 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser  
                405                 410                 415      
 
 
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser  
            420                 425                 430          
 
 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser  
        435                 440                 445              
 
 
Leu Ser Leu Ser Pro Gly  
    450                  
 
 
<210>  226 
<211>  454 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047313 Heavy Chain 
 
<400>  226 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr  
            20                  25                  30           
 
 
Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Arg Phe  
    50                  55                  60                   
 
 
Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu  
            100                 105                 110          
 
 
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr  
        115                 120                 125              
 
 
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser  
    130                 135                 140                  
 
 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu  
145                 150                 155                 160  
 
 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His  
                165                 170                 175      
 
 
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser  
            180                 185                 190          
 
 
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys  
        195                 200                 205              
 
 
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu  
    210                 215                 220                  
 
 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro  
225                 230                 235                 240  
 
 
Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys  
                245                 250                 255      
 
 
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val  
            260                 265                 270          
 
 
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp  
        275                 280                 285              
 
 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr  
    290                 295                 300                  
 
 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp  
305                 310                 315                 320  
 
 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu  
                325                 330                 335      
 
 
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg  
            340                 345                 350          
 
 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys  
        355                 360                 365              
 
 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp  
    370                 375                 380                  
 
 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys  
385                 390                 395                 400  
 
 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser  
                405                 410                 415      
 
 
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser  
            420                 425                 430          
 
 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser  
        435                 440                 445              
 
 
Leu Ser Leu Ser Pro Gly  
    450                  
 
 
<210>  227 
<211>  454 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047314 Heavy Chain 
 
<400>  227 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr  
            20                  25                  30           
 
 
Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Gln Phe  
    50                  55                  60                   
 
 
Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu  
            100                 105                 110          
 
 
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr  
        115                 120                 125              
 
 
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser  
    130                 135                 140                  
 
 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu  
145                 150                 155                 160  
 
 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His  
                165                 170                 175      
 
 
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser  
            180                 185                 190          
 
 
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys  
        195                 200                 205              
 
 
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu  
    210                 215                 220                  
 
 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro  
225                 230                 235                 240  
 
 
Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys  
                245                 250                 255      
 
 
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val  
            260                 265                 270          
 
 
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp  
        275                 280                 285              
 
 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr  
    290                 295                 300                  
 
 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp  
305                 310                 315                 320  
 
 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu  
                325                 330                 335      
 
 
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg  
            340                 345                 350          
 
 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys  
        355                 360                 365              
 
 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp  
    370                 375                 380                  
 
 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys  
385                 390                 395                 400  
 
 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser  
                405                 410                 415      
 
 
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser  
            420                 425                 430          
 
 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser  
        435                 440                 445              
 
 
Leu Ser Leu Ser Pro Gly  
    450                  
 
 
<210>  228 
<211>  454 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047317 Heavy Chain 
 
<400>  228 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr  
            20                  25                  30           
 
 
Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Gln Phe  
    50                  55                  60                   
 
 
Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu  
            100                 105                 110          
 
 
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr  
        115                 120                 125              
 
 
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser  
    130                 135                 140                  
 
 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu  
145                 150                 155                 160  
 
 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His  
                165                 170                 175      
 
 
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser  
            180                 185                 190          
 
 
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys  
        195                 200                 205              
 
 
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu  
    210                 215                 220                  
 
 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro  
225                 230                 235                 240  
 
 
Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys  
                245                 250                 255      
 
 
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val  
            260                 265                 270          
 
 
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp  
        275                 280                 285              
 
 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr  
    290                 295                 300                  
 
 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp  
305                 310                 315                 320  
 
 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu  
                325                 330                 335      
 
 
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg  
            340                 345                 350          
 
 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys  
        355                 360                 365              
 
 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp  
    370                 375                 380                  
 
 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys  
385                 390                 395                 400  
 
 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser  
                405                 410                 415      
 
 
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser  
            420                 425                 430          
 
 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser  
        435                 440                 445              
 
 
Leu Ser Leu Ser Pro Gly  
    450                  
 
 
<210>  229 
<211>  454 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047318 Heavy Chain 
 
<400>  229 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr  
            20                  25                  30           
 
 
Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Gln Phe  
    50                  55                  60                   
 
 
Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu  
            100                 105                 110          
 
 
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr  
        115                 120                 125              
 
 
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser  
    130                 135                 140                  
 
 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu  
145                 150                 155                 160  
 
 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His  
                165                 170                 175      
 
 
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser  
            180                 185                 190          
 
 
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys  
        195                 200                 205              
 
 
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu  
    210                 215                 220                  
 
 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro  
225                 230                 235                 240  
 
 
Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys  
                245                 250                 255      
 
 
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val  
            260                 265                 270          
 
 
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp  
        275                 280                 285              
 
 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr  
    290                 295                 300                  
 
 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp  
305                 310                 315                 320  
 
 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu  
                325                 330                 335      
 
 
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg  
            340                 345                 350          
 
 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys  
        355                 360                 365              
 
 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp  
    370                 375                 380                  
 
 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys  
385                 390                 395                 400  
 
 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser  
                405                 410                 415      
 
 
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser  
            420                 425                 430          
 
 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser  
        435                 440                 445              
 
 
Leu Ser Leu Ser Pro Gly  
    450                  
 
 
<210>  230 
<211>  454 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047319 Heavy Chain 
 
<400>  230 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr  
            20                  25                  30           
 
 
Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu  
            100                 105                 110          
 
 
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr  
        115                 120                 125              
 
 
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser  
    130                 135                 140                  
 
 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu  
145                 150                 155                 160  
 
 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His  
                165                 170                 175      
 
 
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser  
            180                 185                 190          
 
 
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys  
        195                 200                 205              
 
 
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu  
    210                 215                 220                  
 
 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro  
225                 230                 235                 240  
 
 
Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys  
                245                 250                 255      
 
 
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val  
            260                 265                 270          
 
 
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp  
        275                 280                 285              
 
 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr  
    290                 295                 300                  
 
 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp  
305                 310                 315                 320  
 
 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu  
                325                 330                 335      
 
 
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg  
            340                 345                 350          
 
 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys  
        355                 360                 365              
 
 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp  
    370                 375                 380                  
 
 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys  
385                 390                 395                 400  
 
 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser  
                405                 410                 415      
 
 
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser  
            420                 425                 430          
 
 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser  
        435                 440                 445              
 
 
Leu Ser Leu Ser Pro Gly  
    450                  
 
 
<210>  231 
<211>  454 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047320 Heavy Chain 
 
<400>  231 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr  
            20                  25                  30           
 
 
Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Gln Phe  
    50                  55                  60                   
 
 
Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu  
            100                 105                 110          
 
 
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr  
        115                 120                 125              
 
 
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser  
    130                 135                 140                  
 
 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu  
145                 150                 155                 160  
 
 
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His  
                165                 170                 175      
 
 
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser  
            180                 185                 190          
 
 
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys  
        195                 200                 205              
 
 
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu  
    210                 215                 220                  
 
 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro  
225                 230                 235                 240  
 
 
Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys  
                245                 250                 255      
 
 
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val  
            260                 265                 270          
 
 
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp  
        275                 280                 285              
 
 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr  
    290                 295                 300                  
 
 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp  
305                 310                 315                 320  
 
 
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu  
                325                 330                 335      
 
 
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg  
            340                 345                 350          
 
 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys  
        355                 360                 365              
 
 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp  
    370                 375                 380                  
 
 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys  
385                 390                 395                 400  
 
 
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser  
                405                 410                 415      
 
 
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser  
            420                 425                 430          
 
 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser  
        435                 440                 445              
 
 
Leu Ser Leu Ser Pro Gly  
    450                  
 
 
<210>  232 
<211>  456 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047322 Heavy Chain 
 
<400>  232 
 
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
1               5                   10                  15       
 
 
Ser Val Lys Val Ser Cys Lys Ser Ser Gly Gly Thr Phe Ser Ser Tyr  
            20                  25                  30           
 
 
Ala Phe Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
        35                  40                  45               
 
 
Gly Gly Ile Ile Pro Ile Phe Arg Thr Ala Asn Tyr Ala Gln Lys Phe  
    50                  55                  60                   
 
 
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr  
65                  70                  75                  80   
 
 
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                85                  90                  95       
 
 
Ala Ser Ser His Phe Ser Gly Ser Gly Ser Ser His Tyr Tyr Tyr Tyr  
            100                 105                 110          
 
 
Gly Met His Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala  
        115                 120                 125              
 
 
Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser  
    130                 135                 140                  
 
 
Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe  
145                 150                 155                 160  
 
 
Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly  
                165                 170                 175      
 
 
Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu  
            180                 185                 190          
 
 
Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr  
        195                 200                 205              
 
 
Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg  
    210                 215                 220                  
 
 
Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro  
225                 230                 235                 240  
 
 
Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys  
                245                 250                 255      
 
 
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val  
            260                 265                 270          
 
 
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr  
        275                 280                 285              
 
 
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu  
    290                 295                 300                  
 
 
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His  
305                 310                 315                 320  
 
 
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys  
                325                 330                 335      
 
 
Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln  
            340                 345                 350          
 
 
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met  
        355                 360                 365              
 
 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro  
    370                 375                 380                  
 
 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn  
385                 390                 395                 400  
 
 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu  
                405                 410                 415      
 
 
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val  
            420                 425                 430          
 
 
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln  
        435                 440                 445              
 
 
Lys Ser Leu Ser Leu Ser Pro Gly  
    450                 455      
 
 
<210>  233 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047239 Light Chain 
 
<400>  233 
 
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
 
 
Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Tyr  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  234 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047246 Light Chain 
 
<400>  234 
 
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
 
 
Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Tyr  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  235 
<211>  215 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047247 Light Chain 
 
<400>  235 
 
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly  
1               5                   10                  15       
 
 
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser  
            20                  25                  30           
 
 
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu  
        35                  40                  45               
 
 
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Glu Arg Phe Ser  
    50                  55                  60                   
 
 
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu  
65                  70                  75                  80   
 
 
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro  
                85                  90                  95       
 
 
Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala  
            100                 105                 110          
 
 
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser  
        115                 120                 125              
 
 
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu  
    130                 135                 140                  
 
 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser  
145                 150                 155                 160  
 
 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu  
                165                 170                 175      
 
 
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val  
            180                 185                 190          
 
 
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys  
        195                 200                 205              
 
 
Ser Phe Asn Arg Gly Glu Cys  
    210                 215  
 
 
<210>  236 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047248 Light Chain 
 
<400>  236 
 
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly  
1               5                   10                  15       
 
 
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser  
            20                  25                  30           
 
 
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu  
        35                  40                  45               
 
 
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser  
    50                  55                  60                   
 
 
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu  
65                  70                  75                  80   
 
 
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  237 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047323 Light Chain 
 
<400>  237 
 
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
 
 
Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Ile  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  238 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047328 Light Chain 
 
<400>  238 
 
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
 
 
Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Ile  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  239 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047334 Light Chain 
 
<400>  239 
 
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  240 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047263 Light Chain 
 
<400>  240 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Pro  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  241 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047265 Light Chain 
 
<400>  241 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  242 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047289 Light Chain 
 
<400>  242 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  243 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047290 Light Chain 
 
<400>  243 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  244 
 
<400>  244 
000 
 
<210>  245 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047291 Light Chain 
 
<400>  245 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  246 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047292 Light Chain 
 
<400>  246 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  247 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047294 Light Chain 
 
<400>  247 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  248 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047296 Light Chain 
 
<400>  248 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Ile  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  249 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047297 Light Chain 
 
<400>  249 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  250 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047299 Light Chain 
 
<400>  250 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Trp  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  251 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047300 Light Chain 
 
<400>  251 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
His Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  252 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047301 Light Chain 
 
<400>  252 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  253 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047302 Light Chain 
 
<400>  253 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  254 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047305 Light Chain 
 
<400>  254 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  255 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047306 Light Chain 
 
<400>  255 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  256 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047307 Light Chain 
 
<400>  256 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  257 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047308 Light Chain 
 
<400>  257 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  258 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047309 Light Chain 
 
<400>  258 
 
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Phe  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  259 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047310 Light Chain 
 
<400>  259 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  260 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047311 Light Chain 
 
<400>  260 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  261 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047312 Light Chain 
 
<400>  261 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  262 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047313 Light Chain 
 
<400>  262 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Trp  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  263 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047314 Light Chain 
 
<400>  263 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  264 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047317 Light Chain 
 
<400>  264 
 
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly  
1               5                   10                  15       
 
 
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile  
        35                  40                  45               
 
 
Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu  
                85                  90                  95       
 
 
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  265 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047318 Light Chain 
 
<400>  265 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  266 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047319 Light Chain 
 
<400>  266 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  267 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047320 Light Chain 
 
<400>  267 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  268 
<211>  214 
<212>  PRT 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047322 Light Chain 
 
<400>  268 
 
Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly  
1               5                   10                  15       
 
 
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp  
            20                  25                  30           
 
 
Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile  
        35                  40                  45               
 
 
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly  
    50                  55                  60                   
 
 
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro  
65                  70                  75                  80   
 
 
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr  
                85                  90                  95       
 
 
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala  
            100                 105                 110          
 
 
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly  
        115                 120                 125              
 
 
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala  
    130                 135                 140                  
 
 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln  
145                 150                 155                 160  
 
 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser  
                165                 170                 175      
 
 
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr  
            180                 185                 190          
 
 
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser  
        195                 200                 205              
 
 
Phe Asn Arg Gly Glu Cys  
    210                  
 
 
<210>  269 
<211>  1362 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047239 Heavy Chain 
 
<400>  269 
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60 
 
tcctgtgcag ctactgaatt caccttcagt aactatggca tgcactgggt ccgccaggct      120 
 
ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaatactat      180 
 
gcagactccg tgaagggccg cttcaccatc tccagagaca attccaagaa cacgctgtat      240 
 
ctgcaattga acagcctgag cgccgaggac tcggctgtgt attactgtgc gagagatggg      300 
 
aggcattact atggttcgac ctcctacttc ggcatggacg tctggggcca agggaccacg      360 
 
gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420 
 
aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480 
 
ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540 
 
gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600 
 
ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660 
 
aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720 
 
gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780 
 
atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840 
 
gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900 
 
gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960 
 
tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020 
 
gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080 
 
ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140 
 
tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200 
 
accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260 
 
gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320 
 
cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362 
 
 
<210>  270 
<211>  1353 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047246 Heavy Chain 
 
<400>  270 
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60 
 
acctgcactg tctctggtgg ctccatcact aattactact ggacctggat ccggcagccc      120 
 
ccagggaagg gactggagtg gattgggtat atctatgaca gtgggtacac caactacaac      180 
 
ccctccctca agagtcgagt caccttatca atagacacgt ccaagaacca gttctccctg      240 
 
aagctgagct ctgtgaccgc tgcggacacg gccgtttatt actgtgcgag aggggttcta      300 
 
tggttcgggg agttattacc tctccttgac tactggggcc agggaaccct ggtcaccgtc      360 
 
tcctcagcgt cgaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      420 
 
tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480 
 
gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540 
 
tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      600 
 
cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagagagtt      660 
 
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgaa      720 
 
ggggccccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780 
 
acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      840 
 
aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900 
 
tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      960 
 
ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc caagcagcat cgagaaaacc     1020 
 
atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1080 
 
gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1140 
 
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1200 
 
cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1260 
 
aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320 
 
tacacgcaga agagcctctc cctgtccccg ggt                                  1353 
 
 
<210>  271 
<211>  1353 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047247 Heavy Chain 
 
<400>  271 
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60 
 
acctgcactg tctctggtgg ctccatcact aattactact ggacctggat ccggcagccc      120 
 
ccagggaagg gactggagtg gattgggtat atctatgaca gtgggtacac caactacaac      180 
 
ccctccctca agagtcgagt caccttatca atagacacgt ccaagaacca gttctccctg      240 
 
aagctgagct ctgtgaccgc tgcggacacg gccgtttatt actgtgcgag aggggttcta      300 
 
tggttcgggg agttattacc tctccttgac tactggggcc agggaaccct ggtcaccgtc      360 
 
tcctcagcgt cgaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      420 
 
tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480 
 
gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540 
 
tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      600 
 
cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagagagtt      660 
 
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgaa      720 
 
ggggccccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780 
 
acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      840 
 
aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900 
 
tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      960 
 
ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc caagcagcat cgagaaaacc     1020 
 
atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1080 
 
gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1140 
 
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1200 
 
cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1260 
 
aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320 
 
tacacgcaga agagcctctc cctgtccccg ggt                                  1353 
 
 
<210>  272 
<211>  1359 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047248 Heavy Chain 
 
<400>  272 
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60 
 
acctgcactg tgtctggtgg ctccatcagt agttcctact ggagctgggt ccggcagccc      120 
 
ccagggaagg gactggagtg gattggatat acccattaca gtgggatcag caactacaac      180 
 
ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240 
 
aagctgagct ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agaagggtac      300 
 
gatattttga ctggttatga gtactacggt atggacgtct ggggccaagg gaccacggtc      360 
 
accgtctcct cagcgtcgac caagggccca tcggtcttcc ccctggcacc ctcctccaag      420 
 
agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      480 
 
gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      540 
 
ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      600 
 
ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      660 
 
agagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      720 
 
gccgaagggg ccccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      780 
 
tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      840 
 
aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      900 
 
gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      960 
 
ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccaag cagcatcgag     1020 
 
aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1080 
 
tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1140 
 
cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1200 
 
acgcctcccg tgctggactc cgacggctcc ttcttcctct atagcaagct caccgtggac     1260 
 
aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1320 
 
aaccactaca cgcagaagag cctctccctg tccccgggt                            1359 
 
 
<210>  273 
<211>  1365 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047323 Heavy Chain 
 
<400>  273 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcatc aatagcgaag ctatcaactg ggtgcgacag      120 
 
gcccctggac aagggcttga gtggatggga gggatcatcc ctatctttga cattacaaac      180 
 
tacgcacaga agttccaggg cagagtcacg attaccgcgg acgaatccat gagcacagcc      240 
 
tacatggagc tgagcagcct gagatctgag gacacggccg tgtattactg tgcgaagacg      300 
 
tattacgata ttttgactta tcactatcac tacggtatgg acgtctgggg ccaagggacc      360 
 
acggtcaccg tctcctcagc gtcgaccaag ggcccatcgg tcttccccct ggcaccctcc      420 
 
tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      480 
 
gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540 
 
gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600 
 
agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      660 
 
gacaagagag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      720 
 
cctgaagccg aaggggcccc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      780 
 
atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      840 
 
gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      900 
 
cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      960 
 
gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccaagcagc     1020 
 
atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1080 
 
cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1140 
 
ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1200 
 
aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc     1260 
 
gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1320 
 
ctgcacaacc actacacgca gaagagcctc tccctgtccc cgggt                     1365 
 
 
<210>  274 
<211>  1365 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047328 Heavy Chain 
 
<400>  274 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcatc aatagcgaag ctatcaactg ggtgcgacag      120 
 
gcccctggac aagggcttga gtggatggga gggatcatcc ctatctttga cattacaaac      180 
 
tacgcacaga agttccaggg cagagtcacg attaccgcgg acgaatccat gagcacagcc      240 
 
tacatggagc tgagcagcct gagatctgag gacacggccg tgtattactg tgcgaagacg      300 
 
tattacgata ttttgactta tcactatcac tacggtatgg acgtctgggg ccaagggacc      360 
 
acggtcaccg tctcctcagc gtcgaccaag ggcccatcgg tcttccccct ggcaccctcc      420 
 
tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      480 
 
gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540 
 
gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600 
 
agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      660 
 
gacaagagag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      720 
 
cctgaagccg aaggggcccc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      780 
 
atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      840 
 
gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      900 
 
cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      960 
 
gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccaagcagc     1020 
 
atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1080 
 
cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1140 
 
ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1200 
 
aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc     1260 
 
gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1320 
 
ctgcacaacc actacacgca gaagagcctc tccctgtccc cgggt                     1365 
 
 
<210>  275 
<211>  1356 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047334 Heavy Chain 
 
<400>  275 
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc tgtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagt agttccgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac aacaaacggc      180 
 
gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240 
 
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc ggctatggtt      300 
 
cggggaaatt acttctactt ctacggtatg gacgtctggg gccaagggac cacggtcacc      360 
 
gtctcctcag cgtcgaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      420 
 
acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480 
 
acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540 
 
cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600 
 
acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaga      660 
 
gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaagcc      720 
 
gaaggggccc cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      780 
 
cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      840 
 
ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900 
 
cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      960 
 
aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccaagcag catcgagaaa     1020 
 
accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1080 
 
cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1140 
 
agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200 
 
cctcccgtgc tggactccga cggctccttc ttcctctata gcaagctcac cgtggacaag     1260 
 
agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320 
 
cactacacgc agaagagcct ctccctgtcc ccgggt                               1356 
 
 
<210>  276 
<211>  1365 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047263 Heavy Chain 
 
<400>  276 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60 
 
tcctgcaagg cttctggata caccttcccc acttatgata tcaactgggt gcgacaggcc      120 
 
actggacaag ggcttgagtg gatgggatgg gtgaacccta acagtggtaa cacaggctat      180 
 
gcacagaagt tccaggacag agtcaccatg accaggaaca cctccataag cacagcctac      240 
 
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagtgacggc      300 
 
cttaatatgg ttcggggagt tcacaactac tacggtatgg acgtctgggg ccaagggacc      360 
 
acggtcaccg tctcctcagc gtcgaccaag ggcccatcgg tcttccccct ggcaccctcc      420 
 
tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      480 
 
gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540 
 
gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600 
 
agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      660 
 
gacaagagag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      720 
 
cctgaagccg aaggggcccc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      780 
 
atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      840 
 
gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      900 
 
cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      960 
 
gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccaagcagc     1020 
 
atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1080 
 
cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1140 
 
ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1200 
 
aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc     1260 
 
gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1320 
 
ctgcacaacc actacacgca gaagagcctc tccctgtccc cgggt                     1365 
 
 
<210>  277 
<211>  1365 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047265 Heavy Chain 
 
<400>  277 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60 
 
tcctgcaagg cttctggata caccttcccc acttatgata tcaactgggt gcgacaggcc      120 
 
actggacaag ggcttgagtg gatgggatgg gtgaacccta acagtggtaa cacaggctat      180 
 
gcacagaagt tccaggacag agtcaccatg accaggaaca cctccataag cacagcctac      240 
 
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagtgacggc      300 
 
cttaatatgg ttcggggagt tcacaactac tacggtatgg acgtctgggg ccaagggacc      360 
 
acggtcaccg tctcctcagc gtcgaccaag ggcccatcgg tcttccccct ggcaccctcc      420 
 
tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      480 
 
gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540 
 
gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600 
 
agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      660 
 
gacaagagag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      720 
 
cctgaagccg aaggggcccc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      780 
 
atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      840 
 
gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      900 
 
cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      960 
 
gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccaagcagc     1020 
 
atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1080 
 
cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1140 
 
ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1200 
 
aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc     1260 
 
gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1320 
 
ctgcacaacc actacacgca gaagagcctc tccctgtccc cgggt                     1365 
 
 
<210>  278 
<211>  1365 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047289 Heavy Chain 
 
<400>  278 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagc agctctgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggagga atcatcccta tcttcggtac agcagactcc      180 
 
gcacagaagt tccagggcag agtcacgatt accgcggacg agtccacgag cacagcctac      240 
 
atggaattga acagcctgag atctgaggac acggccgttt actactgtgc gttcacaccc      300 
 
cggtatcgtg ggagctccca ccactacttc tacgctttgg gcgtctgggg ccaagggacc      360 
 
acggtcaccg tctcctcagc gtcgaccaag ggcccatcgg tcttccccct ggcaccctcc      420 
 
tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      480 
 
gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540 
 
gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600 
 
agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      660 
 
gacaagagag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      720 
 
cctgaagccg aaggggcccc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      780 
 
atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      840 
 
gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      900 
 
cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      960 
 
gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccaagcagc     1020 
 
atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1080 
 
cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1140 
 
ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1200 
 
aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc     1260 
 
gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1320 
 
ctgcacaacc actacacgca gaagagcctc tccctgtccc cgggt                     1365 
 
 
<210>  279 
<211>  1368 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047290 Heavy Chain 
 
<400>  279 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcaac agacatgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180 
 
gcgcagaagt tccagggcag agtcacgatt gccgcggacg aacccacgag cacaacctac      240 
 
atggagctgc gcagcctgag atctgaggac acggccgtgt attactgtgc gagttcgtat      300 
 
ttctatggtt cggggagttc caactactac tactacggtt tggacgtctg gggccaaggg      360 
 
accacggtca ccgtctcctc agcgtcgacc aagggcccat cggtcttccc cctggcaccc      420 
 
tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480 
 
cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540 
 
ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600 
 
agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660 
 
gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720 
 
gcacctgaag ccgaaggggc cccgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780 
 
ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840 
 
cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900 
 
ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960 
 
caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccaagc     1020 
 
agcatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080 
 
ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140 
 
ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200 
 
tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     1260 
 
accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320 
 
gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggt                  1368 
 
 
<210>  280 
 
<400>  280 
000 
 
<210>  281 
<211>  1368 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047291 Heavy Chain 
 
<400>  281 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcaac agacatgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180 
 
gcgcagaagt tccagggcag agtcacgatt gccgcggacg aacccacgag cacaacctac      240 
 
atggagctgc gcagcctgag atctgaggac acggccgtgt attactgtgc gagttcgtat      300 
 
ttctatggtt cggggagttc caactactac tactacggtt tggacgtctg gggccaaggg      360 
 
accacggtca ccgtctcctc agcgtcgacc aagggcccat cggtcttccc cctggcaccc      420 
 
tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480 
 
cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540 
 
ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600 
 
agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660 
 
gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720 
 
gcacctgaag ccgaaggggc cccgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780 
 
ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840 
 
cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900 
 
ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960 
 
caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccaagc     1020 
 
agcatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080 
 
ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140 
 
ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200 
 
tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     1260 
 
accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320 
 
gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggt                  1368 
 
 
<210>  282 
<211>  1365 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047292 Heavy Chain 
 
<400>  282 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagc agctctgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttagtac aggaaactac      180 
 
gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgaa cacagcctac      240 
 
atggatctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatccact      300 
 
agggttcggg gagtttccca ctactactac tacggtttgg acgtctgggg ccaagggacc      360 
 
acggtcaccg tctcctcagc gtcgaccaag ggcccatcgg tcttccccct ggcaccctcc      420 
 
tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      480 
 
gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540 
 
gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600 
 
agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      660 
 
gacaagagag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      720 
 
cctgaagccg aaggggcccc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      780 
 
atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      840 
 
gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      900 
 
cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      960 
 
gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccaagcagc     1020 
 
atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1080 
 
cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1140 
 
ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1200 
 
aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc     1260 
 
gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1320 
 
ctgcacaacc actacacgca gaagagcctc tccctgtccc cgggt                     1365 
 
 
<210>  283 
<211>  1368 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047294 Heavy Chain 
 
<400>  283 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcaac agacatgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180 
 
gcgcaggagt tccagggcag agtcacgatt gccgcggacg aacccacgag cacaacctac      240 
 
atggagctgc gcagcctgag atctgaggac acggccgtgt attactgtgc gagttcgtat      300 
 
ttctatggtt cggggagttc caactactac tactacggtt tggacgtctg gggccaaggg      360 
 
accacggtca ccgtctcctc agcgtcgacc aagggcccat cggtcttccc cctggcaccc      420 
 
tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480 
 
cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540 
 
ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600 
 
agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660 
 
gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720 
 
gcacctgaag ccgaaggggc cccgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780 
 
ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840 
 
cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900 
 
ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960 
 
caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccaagc     1020 
 
agcatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080 
 
ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140 
 
ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200 
 
tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     1260 
 
accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320 
 
gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggt                  1368 
 
 
<210>  284 
<211>  1368 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047296 Heavy Chain 
 
<400>  284 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcaac agacatgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180 
 
gcgcagaagt tccagggcag agtcacgatt gccgcggacg aacccacgag cacaacctac      240 
 
atggagctgc gcagcctgag atctgaggac acggccgtgt attactgtgc gagttcgtat      300 
 
ttctatggtt cggggagttc caactactac tactacggtt tggacgtctg gggccaaggg      360 
 
accacggtca ccgtctcctc agcgtcgacc aagggcccat cggtcttccc cctggcaccc      420 
 
tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480 
 
cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540 
 
ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600 
 
agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660 
 
gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720 
 
gcacctgaag ccgaaggggc cccgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780 
 
ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840 
 
cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900 
 
ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960 
 
caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccaagc     1020 
 
agcatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080 
 
ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140 
 
ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200 
 
tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     1260 
 
accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320 
 
gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggt                  1368 
 
 
<210>  285 
<211>  1368 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047297 Heavy Chain 
 
<400>  285 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcaac agacatgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180 
 
gcgcagaagt tccagggcag agtcacgatt gccgcggacg aacccacgag cacaacctac      240 
 
atggagctgc gcagcctgag atctgaggac acggccgtgt attactgtgc gagttcgtat      300 
 
ttctatggtt cggggagttc caactactac tactacggtt tggacgtctg gggccaaggg      360 
 
accacggtca ccgtctcctc agcgtcgacc aagggcccat cggtcttccc cctggcaccc      420 
 
tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480 
 
cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540 
 
ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600 
 
agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660 
 
gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720 
 
gcacctgaag ccgaaggggc cccgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780 
 
ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840 
 
cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900 
 
ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960 
 
caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccaagc     1020 
 
agcatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080 
 
ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140 
 
ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200 
 
tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     1260 
 
accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320 
 
gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggt                  1368 
 
 
<210>  286 
<211>  1368 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047299 Heavy Chain 
 
<400>  286 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcaac agatatgctt tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac acccaactac      180 
 
gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacggcctac      240 
 
atggagctga gcagcctgat atctgaggac acggccgtgt attactgtgc gagcagccat      300 
 
ttctatggtt cggggagttc ccacttttac tactacggta tgcacgtctg gggccaaggg      360 
 
accacggtca ccgtctcctc agcgtcgacc aagggcccat cggtcttccc cctggcaccc      420 
 
tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480 
 
cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540 
 
ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600 
 
agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660 
 
gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720 
 
gcacctgaag ccgaaggggc cccgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780 
 
ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840 
 
cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900 
 
ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960 
 
caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccaagc     1020 
 
agcatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080 
 
ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140 
 
ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200 
 
tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     1260 
 
accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320 
 
gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggt                  1368 
 
 
<210>  287 
<211>  1368 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047300 Heavy Chain 
 
<400>  287 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcaac agacatgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180 
 
gcgcagaagt tccagggcag agtcacgatt gccgcggacg aacccacgag cacaacctac      240 
 
atggagctgc gcagcctgag atctgaggac acggccgtgt attactgtgc aagttcgtat      300 
 
ttctatggtt cggggagttc caactactac tactacggtt tggacgtctg gggccaaggg      360 
 
accacggtca ccgtctcctc agcgtcgacc aagggcccat cggtcttccc cctggcaccc      420 
 
tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480 
 
cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540 
 
ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600 
 
agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660 
 
gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720 
 
gcacctgaag ccgaaggggc cccgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780 
 
ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840 
 
cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900 
 
ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960 
 
caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccaagc     1020 
 
agcatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080 
 
ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140 
 
ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200 
 
tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     1260 
 
accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320 
 
gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggt                  1368 
 
 
<210>  288 
<211>  1368 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047301 Heavy Chain 
 
<400>  288 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcaac agatatgctt tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac acccaactac      180 
 
gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacggcctac      240 
 
atggagctga gcagcctgat atctgaggac acggccgtgt attactgtgc gagcagccat      300 
 
ttctatggtt cggggagttc caactactac tactacggtt tggacgtctg gggccaaggg      360 
 
accacggtca ccgtctcctc agcgtcgacc aagggcccat cggtcttccc cctggcaccc      420 
 
tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480 
 
cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540 
 
ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600 
 
agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660 
 
gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720 
 
gcacctgaag ccgaaggggc cccgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780 
 
ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840 
 
cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900 
 
ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960 
 
caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccaagc     1020 
 
agcatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080 
 
ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140 
 
ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200 
 
tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     1260 
 
accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320 
 
gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggt                  1368 
 
 
<210>  289 
<211>  1368 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047302 Heavy Chain 
 
<400>  289 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcaac agacatgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180 
 
gcgcagaagt tccagggcag agtcacgatt gccgcggacg aacccacgag cacaacctac      240 
 
atggagctgc gcagcctgag atctgaggac acggccgtgt attactgtgc gagttcgtat      300 
 
ttctatggtt cggggagttc caactattac tactacggtt tggacgtctg gggccaaggg      360 
 
accacggtca ccgtctcctc agcgtcgacc aagggcccat cggtcttccc cctggcaccc      420 
 
tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480 
 
cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540 
 
ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600 
 
agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660 
 
gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720 
 
gcacctgaag ccgaaggggc cccgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780 
 
ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840 
 
cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900 
 
ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960 
 
caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccaagc     1020 
 
agcatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080 
 
ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140 
 
ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200 
 
tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     1260 
 
accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320 
 
gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggt                  1368 
 
 
<210>  290 
<211>  1365 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047305 Heavy Chain 
 
<400>  290 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaaga cttctggagg caccttcagc agctctgctg tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgaatg gatgggagga atcaccccta tttttggtac agcagactac      180 
 
gcacagaagt tccagggcag agtcacgatt accgcggacg catccacgag cacaggttat      240 
 
atggaactga gcagcctgag atctgaggac acggccgttt actactgtgc gttcacaccc      300 
 
cgatatcgtg ggagctccca ccactactac tacgctttgg gcgtctgggg ccaagggacc      360 
 
acggtcaccg tctcctcagc gtcgaccaag ggcccatcgg tcttccccct ggcaccctcc      420 
 
tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      480 
 
gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540 
 
gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600 
 
agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      660 
 
gacaagagag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      720 
 
cctgaagccg aaggggcccc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      780 
 
atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      840 
 
gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      900 
 
cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      960 
 
gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccaagcagc     1020 
 
atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1080 
 
cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1140 
 
ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1200 
 
aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc     1260 
 
gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1320 
 
ctgcacaacc actacacgca gaagagcctc tccctgtccc cgggt                     1365 
 
 
<210>  291 
<211>  1362 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047306 Heavy Chain 
 
<400>  291 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagc agctctgcta tcagctgggt acgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcgaactac      180 
 
gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240 
 
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagcctcc      300 
 
caaagcagga gctcgaacta ctactactac ggtctggacg tctggggcca agggaccacg      360 
 
gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420 
 
aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480 
 
ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540 
 
gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600 
 
ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660 
 
aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720 
 
gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780 
 
atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840 
 
gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900 
 
gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960 
 
tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020 
 
gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080 
 
ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140 
 
tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200 
 
accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260 
 
gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320 
 
cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362 
 
 
<210>  292 
<211>  1362 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047307 Heavy Chain 
 
<400>  292 
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac accaaactac      180 
 
gcacagcagt tccaggacag agtcacgatt accgcggacg aatccacgag gacagcctac      240 
 
atggagctga atagcctgaa atctgaggac acggccgtat attactgtgc gaggggacat      300 
 
ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360 
 
gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420 
 
aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480 
 
ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540 
 
gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600 
 
ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660 
 
aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720 
 
gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780 
 
atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840 
 
gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900 
 
gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960 
 
tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020 
 
gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080 
 
ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140 
 
tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200 
 
accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260 
 
gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320 
 
cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362 
 
 
<210>  293 
<211>  1362 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047308 Heavy Chain 
 
<400>  293 
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180 
 
gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgaa tacagcctac      240 
 
atggagctga gtagcctgag atctgaggac acggccgtgt attactgtgc gaggggacat      300 
 
ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360 
 
gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420 
 
aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480 
 
ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540 
 
gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600 
 
ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660 
 
aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720 
 
gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780 
 
atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840 
 
gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900 
 
gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960 
 
tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020 
 
gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080 
 
ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140 
 
tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200 
 
accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260 
 
gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320 
 
cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362 
 
 
<210>  294 
<211>  1338 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047309 Heavy Chain 
 
<400>  294 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaacc cttctggagg caccttcagc acctacgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcaacccta tctttggaac agcaaactac      180 
 
gcacagaagt tccagggcag agtcacaatt accgcggacg aatccacgag tccaggctac      240 
 
ctggagctga gcagcctgag atctgaggac acggccgttt attactgtgc gagaggggga      300 
 
gcagtgggtt ttgcctattg gggccaggga accctggtca ccgtctcctc agcgtcgacc      360 
 
aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420 
 
gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480 
 
ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540 
 
tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600 
 
aacgtgaatc acaagcccag caacaccaag gtggacaaga gagttgagcc caaatcttgt      660 
 
gacaaaactc acacatgccc accgtgccca gcacctgaag ccgaaggggc cccgtcagtc      720 
 
ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780 
 
tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840 
 
ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900 
 
cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960 
 
tgcaaggtct ccaacaaagc cctcccaagc agcatcgaga aaaccatctc caaagccaaa     1020 
 
gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080 
 
aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140 
 
tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200 
 
gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     1260 
 
aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320 
 
ctctccctgt ccccgggt                                                   1338 
 
 
<210>  295 
<211>  1362 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047310 Heavy Chain 
 
<400>  295 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagc agatatgcta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac atcaaactac      180 
 
gcacagaagt tccagggcag agtcacgatt aaagcggacg aatccacgag cacagcctac      240 
 
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagggggc      300 
 
aacagctgga ccactagttt gtactactac ggtatggacg tctggggcca agggaccacg      360 
 
gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420 
 
aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480 
 
ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540 
 
gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600 
 
ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660 
 
aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720 
 
gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780 
 
atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840 
 
gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900 
 
gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960 
 
tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020 
 
gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080 
 
ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140 
 
tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200 
 
accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260 
 
gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320 
 
cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362 
 
 
<210>  296 
<211>  1362 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047311 Heavy Chain 
 
<400>  296 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180 
 
gcacagcagt tccaggacag agtcacgatt accgcggacg aatccacgag gacagcctac      240 
 
atggagctga atagcctgaa atctgaggac acggctgtat attactgtgc gaggggacat      300 
 
ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360 
 
gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420 
 
aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480 
 
ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540 
 
gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600 
 
ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660 
 
aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720 
 
gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780 
 
atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840 
 
gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900 
 
gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960 
 
tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020 
 
gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080 
 
ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140 
 
tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200 
 
accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260 
 
gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320 
 
cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362 
 
 
<210>  297 
<211>  1362 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047312 Heavy Chain 
 
<400>  297 
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac accaaactac      180 
 
gcacagcagt tccaggacag agtcacgatt accgcggacg aatccacgag gacagcctac      240 
 
atggagctga atagcctgaa atctgaggac acggccgtat attactgtgc gaggggacat      300 
 
ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360 
 
gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420 
 
aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480 
 
ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540 
 
gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600 
 
ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660 
 
aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720 
 
gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780 
 
atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840 
 
gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900 
 
gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960 
 
tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020 
 
gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080 
 
ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140 
 
tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200 
 
accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260 
 
gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320 
 
cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362 
 
 
<210>  298 
<211>  1362 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047313 Heavy Chain 
 
<400>  298 
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac accaaactac      180 
 
gcacagcggt tccaggacag agtcacgatt accgcggacg aatccacgag gacagcctac      240 
 
atggagctga gtagcctgag atctgaggac acggccgtgt attactgtgc gaggggacat      300 
 
ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360 
 
gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420 
 
aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480 
 
ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540 
 
gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600 
 
ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660 
 
aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720 
 
gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780 
 
atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840 
 
gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900 
 
gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960 
 
tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020 
 
gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080 
 
ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140 
 
tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200 
 
accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260 
 
gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320 
 
cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362 
 
 
<210>  299 
<211>  1362 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047314 Heavy Chain 
 
<400>  299 
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac accaaactac      180 
 
gcacagcagt tccaggacag agtcacgatt accgcggacg aatccacgag gacagcctac      240 
 
atggagctga atagcctgaa atctgaggac acggccgtat attactgtgc gaggggacat      300 
 
ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360 
 
gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420 
 
aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480 
 
ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540 
 
gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600 
 
ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660 
 
aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720 
 
gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780 
 
atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840 
 
gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900 
 
gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960 
 
tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020 
 
gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080 
 
ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140 
 
tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200 
 
accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260 
 
gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320 
 
cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362 
 
 
<210>  300 
<211>  1362 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047317 Heavy Chain 
 
<400>  300 
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac accaaactac      180 
 
gcacagcagt tccaggacag agtcacgatt accgcggacg aatccacgag gacagcctac      240 
 
atggagctga atagcctgaa atctgaggac acggccgtat attactgtgc gaggggacat      300 
 
ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360 
 
gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420 
 
aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480 
 
ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540 
 
gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600 
 
ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660 
 
aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720 
 
gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780 
 
atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840 
 
gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900 
 
gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960 
 
tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020 
 
gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080 
 
ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140 
 
tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200 
 
accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260 
 
gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320 
 
cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362 
 
 
<210>  301 
<211>  1362 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047318 Heavy Chain 
 
<400>  301 
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt ccgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac accaaactac      180 
 
gcacagcagt tccaggacag agtcacgatt accgcggacg aatccacgag gacagcctac      240 
 
atggagctga gtagcctgag atctgaggac acggccgtgt attactgtgc gaggggacat      300 
 
ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360 
 
gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420 
 
aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480 
 
ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540 
 
gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600 
 
ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660 
 
aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720 
 
gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780 
 
atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840 
 
gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900 
 
gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960 
 
tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020 
 
gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080 
 
ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140 
 
tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200 
 
accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260 
 
gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320 
 
cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362 
 
 
<210>  302 
<211>  1362 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047319 Heavy Chain 
 
<400>  302 
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180 
 
gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgaa tacagcctac      240 
 
atggagctga gtagcctgag atctgaggac acggccgtgt attactgtgc gaggggacat      300 
 
ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360 
 
gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420 
 
aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480 
 
ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540 
 
gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600 
 
ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660 
 
aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720 
 
gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780 
 
atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840 
 
gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900 
 
gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960 
 
tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020 
 
gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080 
 
ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140 
 
tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200 
 
accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260 
 
gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320 
 
cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362 
 
 
<210>  303 
<211>  1362 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047320 Heavy Chain 
 
<400>  303 
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac accaaactac      180 
 
gcacagcagt tccaggacag agtcacgatt accgcggacg aatccacgag gacagcctac      240 
 
atggagctga atagcctgaa atctgaggac acggccgtat attactgtgc gaggggacat      300 
 
ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360 
 
gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420 
 
aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480 
 
ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540 
 
gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600 
 
ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660 
 
aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720 
 
gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780 
 
atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840 
 
gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900 
 
gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960 
 
tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020 
 
gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080 
 
ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140 
 
tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200 
 
accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260 
 
gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320 
 
cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362 
 
 
<210>  304 
<211>  1368 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047322 Heavy Chain 
 
<400>  304 
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60 
 
tcctgcaagt cttctggagg caccttcagc agctatgctt tcacctgggt gcgacaggcc      120 
 
cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttcgtac agcaaactac      180 
 
gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240 
 
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagcagccat      300 
 
ttctctggtt cgggaagttc ccactactac tactacggta tgcacgtctg gggccaaggg      360 
 
accacggtca ccgtctcctc agcgtcgacc aagggcccat cggtcttccc cctggcaccc      420 
 
tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480 
 
cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540 
 
ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600 
 
agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660 
 
gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720 
 
gcacctgaag ccgaaggggc cccgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780 
 
ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840 
 
cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900 
 
ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960 
 
caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccaagc     1020 
 
agcatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080 
 
ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140 
 
ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200 
 
tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     1260 
 
accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320 
 
gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggt                  1368 
 
 
<210>  305 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047239 Light Chain 
 
<400>  305 
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaacca      120 
 
gggaaagctc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgtcaacag tttaatagtt acccgtacac ttttggccag      300 
 
gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  306 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047246 Light Chain 
 
<400>  306 
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaacca      120 
 
gggaaagctc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgtcaacag tttaatagtt acccgtacac ttttggccag      300 
 
gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  307 
<211>  645 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047247 Light Chain 
 
<400>  307 
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60 
 
ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120 
 
cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180 
 
gagaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240 
 
cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgct cactttcggc      300 
 
ggagggacca aggtggagat caaacgtacg gtggctgcac catctgtctt catcttcccg      360 
 
ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420 
 
tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480 
 
caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540 
 
acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600 
 
ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645 
 
 
<210>  308 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047248 Light Chain 
 
<400>  308 
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60 
 
ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120 
 
cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180 
 
gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240 
 
cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacctac tttcggcgga      300 
 
gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  309 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047323 Light Chain 
 
<400>  309 
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaacca      120 
 
gggaaagctc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgtcaacag tttaatagtt acccgatcac cttcggccaa      300 
 
gggacacgac tggagattaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  310 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047334 Light Chain 
 
<400>  310 
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaacca      120 
 
gggaaagctc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgatcac cttcggccaa      300 
 
gggacacgac tggagattaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  311 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047334 Light Chain 
 
<400>  311 
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaacca      120 
 
gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgctcac tttcggcgga      300 
 
gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  312 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047263 Light Chain 
 
<400>  312 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt accctccgac ttttggccag      300 
 
gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  313 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047265 Light Chain 
 
<400>  313 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300 
 
gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  314 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047290 Light Chain 
 
<400>  314 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgtcaacag tttaatagtt accctctcac tttcggcgga      300 
 
gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  315 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047291 Light Chain 
 
<400>  315 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300 
 
gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  316 
 
<400>  316 
000 
 
<210>  317 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047291 Light Chain 
 
<400>  317 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gatgattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300 
 
gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  318 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047292 Light Chain 
 
<400>  318 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300 
 
gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  319 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047294 Light Chain 
 
<400>  319 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcggtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgctcac tttcggcgga      300 
 
gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  320 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047296 Light Chain 
 
<400>  320 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgatcac cttcggccaa      300 
 
gggacacgac tggagattaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  321 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047297 Light Chain 
 
<400>  321 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcataaacca      120 
 
gggaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgctcac tttcggcgga      300 
 
gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  322 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047299 Light Chain 
 
<400>  322 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgtggac gttcggccaa      300 
 
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  323 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047300 Light Chain 
 
<400>  323 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatccatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgctcac tttcggcgga      300 
 
gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  324 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047301 Light Chain 
 
<400>  324 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300 
 
gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  325 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047302 Light Chain 
 
<400>  325 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt accctctcac tttcggcgga      300 
 
gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  326 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047305 Light Chain 
 
<400>  326 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300 
 
gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  327 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047306 Light Chain 
 
<400>  327 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt accctctcac tttcggcgga      300 
 
gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  328 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047307 Light Chain 
 
<400>  328 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt accctctcac tttcggcgga      300 
 
gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  329 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047308 Light Chain 
 
<400>  329 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300 
 
gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  330 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047309 Light Chain 
 
<400>  330 
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcataaacca      120 
 
gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttacta ttgtcaacag gctaatagtt tcccgttcac tttcggcgga      300 
 
gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  331 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047310 Light Chain 
 
<400>  331 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacggat tacactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgctcac tttcggcgga      300 
 
gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  332 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047311 Light Chain 
 
<400>  332 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gggaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgctcac tttcggcgga      300 
 
gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  333 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047312 Light Chain 
 
<400>  333 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcataaacca      120 
 
gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300 
 
gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  334 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047313 Light Chain 
 
<400>  334 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcataaacca      120 
 
gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccctggac gttcggccaa      300 
 
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  335 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047314 Light Chain 
 
<400>  335 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300 
 
gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  336 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047317 Light Chain 
 
<400>  336 
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60 
 
ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120 
 
ggccaggctc ccaggctcct catctatggt gcatccagca gggccactgg catcccagac      180 
 
aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct      240 
 
gaagattttg cagtgtatta ctgtcagcag tatggtagct caccgctcac tttcggcgga      300 
 
gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  337 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047318 Light Chain 
 
<400>  337 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcataaacca      120 
 
gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300 
 
gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  338 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047319 Light Chain 
 
<400>  338 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcataaacca      120 
 
gggaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300 
 
gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  339 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047320 Light Chain 
 
<400>  339 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcataaacca      120 
 
gggaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300 
 
gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 
<210>  340 
<211>  642 
<212>  DNA 
<213>  Artificial Sequence 
 
<220> 
<223>  P1-047322 Light Chain 
 
<400>  340 
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60 
 
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120 
 
gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180 
 
aggtttagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240 
 
gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300 
 
gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360 
 
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420 
 
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480 
 
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540 
 
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600 
 
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642 
 
 

