                         SEQUENCE LISTING

<110>  BRISTOL-MYERS SQUIBB COMPANY
 
<120>  ANTI-TREM-1 ANTIBODIES AND USES THEREOF

<130>  3338.1380000/ELE/C-K/DKC

<140>  US 62/874,318
<141>  2019-07-15

<160>  295   

<170>  PatentIn version 3.5

<210>  1
<211>  234
<212>  PRT
<213>  artificial sequence

<220>
<223>  TREM-1, Isoform 1

<400>  1

Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser 
1               5                   10                  15      


Glu Leu Arg Ala Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys 
            20                  25                  30          


Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe 
        35                  40                  45              


Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro 
    50                  55                  60                  


Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val 
65                  70                  75                  80  


Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu 
                85                  90                  95      


Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln 
            100                 105                 110         


Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg 
        115                 120                 125             


Ile Arg Leu Val Val Thr Lys Gly Phe Ser Gly Thr Pro Gly Ser Asn 
    130                 135                 140                 


Glu Asn Ser Thr Gln Asn Val Tyr Lys Ile Pro Pro Thr Thr Thr Lys 
145                 150                 155                 160 


Ala Leu Cys Pro Leu Tyr Thr Ser Pro Arg Thr Val Thr Gln Ala Pro 
                165                 170                 175     


Pro Lys Ser Thr Ala Asp Val Ser Thr Pro Asp Ser Glu Ile Asn Leu 
            180                 185                 190         


Thr Asn Val Thr Asp Ile Ile Arg Val Pro Val Phe Asn Ile Val Ile 
        195                 200                 205             


Leu Leu Ala Gly Gly Phe Leu Ser Lys Ser Leu Val Phe Ser Val Leu 
    210                 215                 220                 


Phe Ala Val Thr Leu Arg Ser Phe Val Pro 
225                 230                 


<210>  2
<211>  225
<212>  PRT
<213>  artificial sequence

<220>
<223>  TREM-1, Isoform 2

<400>  2

Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser 
1               5                   10                  15      


Glu Leu Arg Ala Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys 
            20                  25                  30          


Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe 
        35                  40                  45              


Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro 
    50                  55                  60                  


Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val 
65                  70                  75                  80  


Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu 
                85                  90                  95      


Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln 
            100                 105                 110         


Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg 
        115                 120                 125             


Ile Arg Leu Val Val Thr Lys Gly Phe Ser Gly Thr Pro Gly Ser Asn 
    130                 135                 140                 


Glu Asn Ser Thr Gln Asn Val Tyr Lys Ile Pro Pro Thr Thr Thr Lys 
145                 150                 155                 160 


Ala Leu Cys Pro Leu Tyr Thr Ser Pro Arg Thr Val Thr Gln Ala Pro 
                165                 170                 175     


Pro Lys Ser Thr Ala Asp Val Ser Thr Pro Asp Ser Glu Ile Asn Leu 
            180                 185                 190         


Thr Asn Val Thr Asp Ile Ile Arg Tyr Ser Phe Gln Val Pro Gly Pro 
        195                 200                 205             


Leu Val Trp Thr Leu Ser Pro Leu Phe Pro Ser Leu Cys Ala Glu Arg 
    210                 215                 220                 


Met 
225 


<210>  3
<211>  150
<212>  PRT
<213>  artificial sequence

<220>
<223>  TREM-1, Isoform 3

<400>  3

Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser 
1               5                   10                  15      


Glu Leu Arg Ala Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys 
            20                  25                  30          


Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe 
        35                  40                  45              


Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro 
    50                  55                  60                  


Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val 
65                  70                  75                  80  


Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu 
                85                  90                  95      


Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln 
            100                 105                 110         


Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg 
        115                 120                 125             


Ile Arg Leu Val Val Thr Lys Gly Phe Arg Cys Ser Thr Leu Ser Phe 
    130                 135                 140                 


Ser Trp Leu Val Asp Ser 
145                 150 


<210>  4
<211>  3252
<212>  DNA
<213>  artificial sequence

<220>
<223>  TREM-1, Isoform 1

<400>  4
agcagttgga gctggtgcac aggaaggatg aggaagacca ggctctgggg gctgctgtgg       60

atgctctttg tctcagaact ccgagctgca actaaattaa ctgaggaaaa gtatgaactg      120

aaagaggggc agaccctgga tgtgaaatgt gactacacgc tagagaagtt tgccagcagc      180

cagaaagctt ggcagataat aagggacgga gagatgccca agaccctggc atgcacagag      240

aggccttcaa agaattccca tccagtccaa gtggggagga tcatactaga agactaccat      300

gatcatggtt tactgcgcgt ccgaatggtc aaccttcaag tggaagattc tggactgtat      360

cagtgtgtga tctaccagcc tcccaaggag cctcacatgc tgttcgatcg catccgcttg      420

gtggtgacca agggtttttc agggacccct ggctccaatg agaattctac ccagaatgtg      480

tataagattc ctcctaccac cactaaggcc ttgtgcccac tctataccag ccccagaact      540

gtgacccaag ctccacccaa gtcaactgcc gatgtctcca ctcctgactc tgaaatcaac      600

cttacaaatg tgacagatat catcagggtt ccggtgttca acattgtcat tctcctggct      660

ggtggattcc tgagtaagag cctggtcttc tctgtcctgt ttgctgtcac gctgaggtca      720

tttgtaccct aggcccacga acccacgaga atgtcctctg acttccagcc acatccatct      780

ggcagttgtg ccaagggagg agggaggagg taaaaggcag ggagttaata acatgaatta      840

aatctgtaat caccggctat ttctaaagtc agcgtctcac cttcctgccc actgccctcg      900

ttcctctaat aatcttgggt gggcatttgt gcctcagaaa agaagttaca gccccaaaca      960

tgcttggtcc ttcattccac cagccacttg gggttggcat gaaatacaga cagctcaatg     1020

cttttcaccg taattctctt gtgggggctg tgacatgcag aaggcacacc tgatacttct     1080

cctgctcagt tttgccctgg accatacaat tttggcctga cctggacaga gctcccacta     1140

cagaagcatc ctgctcgccc catgctggga cttcctcttt ctagcatcag acacttgggt     1200

ttcatgctta tgtgtggttc tttccaacac tcccagaaaa gggtgttgaa gattgtggaa     1260

cctggagaaa taagacatcg tggtgagaaa gtgcatcctt ctcagagaaa agagttaaac     1320

tgagtatctt cttctgggga aatactggca ggccgagatg ggatccatag gagagcaaca     1380

acagaccatg tcagacatcc tgtgtgcatt tatcgctgga tcctgaaaat agccccgtga     1440

aggcagaaat gtatgtgact agaacgaggc cacatgaata agccactgcc cactggcagg     1500

agtgaaaact gaagcgctcc ttacctgaag gaccccaaaa ccatatagaa tagaataacc     1560

aggagttccg cctgtgtcta aatgcctctt ttcctgtatc acacaagggt cagggatggt     1620

ggagtaaaag ctctccccct gggaggcttc tggaggctgt ccccatgtgc ttgcctagtt     1680

ccccactctg ccctcctcct cttctctcag tctgctcctg gaacacctgc ctcagtttcc     1740

atgctctctc cagtgccctc cccggtgaag caggtaggtg ttcaggccac cacagagaca     1800

atctctgtgg gagattgtct tgcaatctcc cacagatttc aatcaggatt ttgttatttc     1860

ctactttgag ctttaaaggg aaatgggcct catgggtggg gaaaggatgg tgggtccttc     1920

cagcccaatt tagtgatgcc cagggcagat attatcctca gttcccaaga gcaatcatac     1980

ttttccacac ataccgtgtg tctcatgtta ggtaaatgta tttttacaat gagcaccact     2040

tctgtggaaa aagttccctg cacggggagg tccagcttcc agactgctcc atcgcataag     2100

gacttcccca ttcccctaaa tgctgctctg tcagaacctg cccaggtaat ggtaatgacc     2160

ctagagagat gatttctgaa ccgcaatttt gagcccatta gaaggtgtgt ggtgggcatt     2220

tatttcatcc tgatgctctg gtgagaatct ttgcagacgc actagatcca gaagctgtta     2280

atcttggtgc atttattttc ctacctaaaa gaaccaagca gctcagaggc agtgactgta     2340

caggatgcag tgtttataat aatgctgagc ttgctggtct ggaaccccac actttagcaa     2400

tcccagcatt gttcctgttt atgaagttga caaagtgacc agggcaaggg ggtattatca     2460

ttaaatacac tctaggagag gcagaacaca tgagggcaat gtttttcaga ggtctttagg     2520

ccaccgcatc agattctcct ggagcataaa gcaaatgctt tatgagtcca gggcccctgc     2580

agacctactg tatactagta tacagctccc tcttagtgga tctcaagctt gtttccaaaa     2640

agtcattaca ctccttacca aagcccatga cacattcata cagattcatc cagacataac     2700

ccactgcatg gtccagtgca tgcttgtgtg cttaacttat tatagatcaa gtgttattta     2760

agtccaacat attaaacgtg actgaaatat tatatgcact aaatcggaag acaaatggcc     2820

gtgctggata ctctcccatt tgcacttaca ggccacgcca tgctccatcc tccccatcct     2880

gcctgggaac ctgaccaatg tggctaaacc agcaggctcc ctggctgcca gcttctggct     2940

ggttgagcca atgggaagca tgagaggaga gccgagggtg gggagacagt cagatcaggg     3000

tttctgtcct cagggctccc tccctggcag gtggtggcag gagtggctgc attcccctct     3060

gaaggctcct tcaagcctct cagcaaacag ctcccatctc caagtccagc cacctgttcc     3120

atcctctcct ctgtaggccc agcagtggga atgacccacc actattgcca gcctcagcat     3180

actgaagcac cccttactgg attccctaaa ttctatgcac atgtttatta aatgctcctc     3240

aattacccag tt                                                         3252


<210>  5
<211>  2128
<212>  DNA
<213>  artificial sequence

<220>
<223>  TREM-1, Isoform 2

<400>  5
gtgcaacttt ccgaagcctc taggtcattg tggtgccttg tagctgtccc gggagccctc       60

agcagcagtt ggagctggtg cacaggaagg atgaggaaga ccaggctctg ggggctgctg      120

tggatgctct ttgtctcaga actccgagct gcaactaaat taactgagga aaagtatgaa      180

ctgaaagagg ggcagaccct ggatgtgaaa tgtgactaca cgctagagaa gtttgccagc      240

agccagaaag cttggcagat aataagggac ggagagatgc ccaagaccct ggcatgcaca      300

gagaggcctt caaagaattc ccatccagtc caagtgggga ggatcatact agaagactac      360

catgatcatg gtttactgcg cgtccgaatg gtcaaccttc aagtggaaga ttctggactg      420

tatcagtgtg tgatctacca gcctcccaag gagcctcaca tgctgttcga tcgcatccgc      480

ttggtggtga ccaagggttt ttcagggacc cctggctcca atgagaattc tacccagaat      540

gtgtataaga ttcctcctac caccactaag gccttgtgcc cactctatac cagccccaga      600

actgtgaccc aagctccacc caagtcaact gccgatgtct ccactcctga ctctgaaatc      660

aaccttacaa atgtgacaga tatcatcagg tatagtttcc aggtccctgg gcccctggtt      720

tggacactga gccctttgtt tcccagtctg tgtgctgaga ggatgtgaaa gtgagggaaa      780

ggggagggtg gggcaggaga agacttgagt cacattagtc tgggtagaaa tgtccagggg      840

aagaaggaag tggtgatgga gaatagggga ggctctcagc caggctgtcc ttctccccag      900

ttcaccttct ttgtttcctt gcaacctgag tattaaagag agggaaatgg catcttcccc      960

aagttccagt ggagctcatc caaccccagg ggcctgatgg gcagtgggaa agcactctga     1020

gtgaggggcc ctggatctag tgttggcctg actaactgaa tgtgactttg ggtgagtcag     1080

gaaccctctc tggctttagc ttctttgaca attcagtagg catggtagaa acccaaagct     1140

ggaagacatt gtccacctaa taactctcag caggagctgg agctggggct aaatgcagta     1200

ttggtttttg ccttattgtt ttttaaataa cattgttgca tgtgcccaat tatagataaa     1260

tagaatcaga atttttgcag atgaggtccc tctcagtatt tttaataaga tgtttaggag     1320

atttctaatg tgtaggcaaa cttaagaacc actaacttag caatttcaca cctctttaca     1380

gttattaaat gttgatttat attagaatgt gtttatcatt aaatactgaa ttatcaggat     1440

ggaaatactt ttccacatca ccactagtct aacatgtctt ttttctcata ttctcttcta     1500

gtctttattc atgtttatac atattttaat atggcagtaa gtctaattat acatgttttt     1560

attcttttcc ttgctgaaat tattctttga tgctgctacc taaatttcat aaatataatt     1620

tcaatgagtg catatttttc tatcaattgg gaaagccata acttacataa ccattggcct     1680

gttcttagac attgatatag tgttgataac tctgagataa acatattctt gcagatatat     1740

ttttcttctt ttaaataatt aactcgaaat ttccatgaga taatttaaac actgatatca     1800

ttttgtatac aaatagcatc taccaatggt cttccaaaag attggaaaca atttgcagtg     1860

tgatccatta agcataaata aagcagtgtc atggcaggct tacagacacg gatttagtct     1920

tttaaatcat taaatagtgt gagttaaatc acattcctgc taaaacaaat gtgaactggt     1980

gcctgctcta atttctctat gagtgtagac tccacctcca tatgggtagt ggcagtgcct     2040

ttttccccat tatgttgttt ggggaacaaa gtgctcatta aacttctgtg gaataaatca     2100

aacgaatgat caaaaaaaaa aaaaaaaa                                        2128


<210>  6
<211>  3140
<212>  DNA
<213>  artificial sequence

<220>
<223>  TREM-1, Isoform 3

<400>  6
gtgcaacttt ccgaagcctc taggtcattg tggtgccttg tagctgtccc gggagccctc       60

agcagcagtt ggagctggtg cacaggaagg atgaggaaga ccaggctctg ggggctgctg      120

tggatgctct ttgtctcaga actccgagct gcaactaaat taactgagga aaagtatgaa      180

ctgaaagagg ggcagaccct ggatgtgaaa tgtgactaca cgctagagaa gtttgccagc      240

agccagaaag cttggcagat aataagggac ggagagatgc ccaagaccct ggcatgcaca      300

gagaggcctt caaagaattc ccatccagtc caagtgggga ggatcatact agaagactac      360

catgatcatg gtttactgcg cgtccgaatg gtcaaccttc aagtggaaga ttctggactg      420

tatcagtgtg tgatctacca gcctcccaag gagcctcaca tgctgttcga tcgcatccgc      480

ttggtggtga ccaaggggtt ccggtgttca acattgtcat tctcctggct ggtggattcc      540

tgagtaagag cctggtcttc tctgtcctgt ttgctgtcac gctgaggtca tttgtaccct      600

aggcccacga acccacgaga atgtcctctg acttccagcc acatccatct ggcagttgtg      660

ccaagggagg agggaggagg taaaaggcag ggagttaata acatgaatta aatctgtaat      720

caccggctat ttctaaagtc agcgtctcac cttcctgccc actgccctcg ttcctctaat      780

aatcttgggt gggcatttgt gcctcagaaa agaagttaca gccccaaaca tgcttggtcc      840

ttcattccac cagccacttg gggttggcat gaaatacaga cagctcaatg cttttcaccg      900

taattctctt gtgggggctg tgacatgcag aaggcacacc tgatacttct cctgctcagt      960

tttgccctgg accatacaat tttggcctga cctggacaga gctcccacta cagaagcatc     1020

ctgctcgccc catgctggga cttcctcttt ctagcatcag acacttgggt ttcatgctta     1080

tgtgtggttc tttccaacac tcccagaaaa gggtgttgaa gattgtggaa cctggagaaa     1140

taagacatcg tggtgagaaa gtgcatcctt ctcagagaaa agagttaaac tgagtatctt     1200

cttctgggga aatactggca ggccgagatg ggatccatag gagagcaaca acagaccatg     1260

tcagacatcc tgtgtgcatt tatcgctgga tcctgaaaat agccccgtga aggcagaaat     1320

gtatgtgact agaacgaggc cacatgaata agccactgcc cactggcagg agtgaaaact     1380

gaagcgctcc ttacctgaag gaccccaaaa ccatatagaa tagaataacc aggagttccg     1440

cctgtgtcta aatgcctctt ttcctgtatc acacaagggt cagggatggt ggagtaaaag     1500

ctctccccct gggaggcttc tggaggctgt ccccatgtgc ttgcctagtt ccccactctg     1560

ccctcctcct cttctctcag tctgctcctg gaacacctgc ctcagtttcc atgctctctc     1620

cagtgccctc cccggtgaag caggtaggtg ttcaggccac cacagagaca atctctgtgg     1680

gagattgtct tgcaatctcc cacagatttc aatcaggatt ttgttatttc ctactttgag     1740

ctttaaaggg aaatgggcct catgggtggg gaaaggatgg tgggtccttc cagcccaatt     1800

tagtgatgcc cagggcagat attatcctca gttcccaaga gcaatcatac ttttccacac     1860

ataccgtgtg tctcatgtta ggtaaatgta tttttacaat gagcaccact tctgtggaaa     1920

aagttccctg cacggggagg tccagcttcc agactgctcc atcgcataag gacttcccca     1980

ttcccctaaa tgctgctctg tcagaacctg cccaggtaat ggtaatgacc ctagagagat     2040

gatttctgaa ccgcaatttt gagcccatta gaaggtgtgt ggtgggcatt tatttcatcc     2100

tgatgctctg gtgagaatct ttgcagacgc actagatcca gaagctgtta atcttggtgc     2160

atttattttc ctacctaaaa gaaccaagca gctcagaggc agtgactgta caggatgcag     2220

tgtttataat aatgctgagc ttgctggtct ggaaccccac actttagcaa tcccagcatt     2280

gttcctgttt atgaagttga caaagtgacc agggcaaggg ggtattatca ttaaatacac     2340

tctaggagag gcagaacaca tgagggcaat gtttttcaga ggtctttagg ccaccgcatc     2400

agattctcct ggagcataaa gcaaatgctt tatgagtcca gggcccctgc agacctactg     2460

tatactagta tacagctccc tcttagtgga tctcaagctt gtttccaaaa agtcattaca     2520

ctccttacca aagcccatga cacattcata cagattcatc cagacataac ccactgcatg     2580

gtccagtgca tgcttgtgtg cttaacttat tatagatcaa gtgttattta agtccaacat     2640

attaaacgtg actgaaatat tatatgcact aaatcggaag acaaatggcc gtgctggata     2700

ctctcccatt tgcacttaca ggccacgcca tgctccatcc tccccatcct gcctgggaac     2760

ctgaccaatg tggctaaacc agcaggctcc ctggctgcca gcttctggct ggttgagcca     2820

atgggaagca tgagaggaga gccgagggtg gggagacagt cagatcaggg tttctgtcct     2880

cagggctccc tccctggcag gtggtggcag gagtggctgc attcccctct gaaggctcct     2940

tcaagcctct cagcaaacag ctcccatctc caagtccagc cacctgttcc atcctctcct     3000

ctgtaggccc agcagtggga atgacccacc actattgcca gcctcagcat actgaagcac     3060

cccttactgg attccctaaa ttctatgcac atgtttatta aatgctcctc aattacccag     3120

ttaaaaaaaa aaaaaaaaaa                                                 3140


<210>  7
<211>  233
<212>  PRT
<213>  artificial sequence

<220>
<223>  TREM-1 (Predicted)

<400>  7

Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser 
1               5                   10                  15      


Glu Leu Arg Ala Thr Thr Glu Leu Thr Glu Glu Lys Tyr Glu Tyr Lys 
            20                  25                  30          


Glu Gly Gln Thr Leu Glu Val Lys Cys Asp Tyr Ala Leu Glu Lys Tyr 
        35                  40                  45              


Ala Asn Ser Arg Lys Ala Trp Gln Lys Met Glu Gly Lys Met Pro Lys 
    50                  55                  60                  


Ile Leu Ala Lys Thr Glu Arg Pro Ser Glu Asn Ser His Pro Val Gln 
65                  70                  75                  80  


Val Gly Arg Ile Thr Leu Glu Asp Tyr Pro Asp His Gly Leu Leu Gln 
                85                  90                  95      


Val Gln Met Thr Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln Cys 
            100                 105                 110         


Val Ile Tyr Gln His Pro Lys Glu Ser His Val Leu Phe Asn Pro Ile 
        115                 120                 125             


Cys Leu Val Val Thr Lys Gly Ser Ser Gly Thr Pro Gly Ser Ser Glu 
    130                 135                 140                 


Asn Ser Thr Gln Asn Val Tyr Arg Thr Pro Ser Thr Thr Ala Lys Ala 
145                 150                 155                 160 


Leu Gly Pro Arg Tyr Thr Ser Pro Arg Thr Val Thr Gln Ala Pro Pro 
                165                 170                 175     


Glu Ser Thr Val Val Val Ser Thr Pro Gly Ser Glu Ile Asn Leu Thr 
            180                 185                 190         


Asn Val Thr Asp Ile Ile Arg Val Pro Val Phe Asn Ile Val Ile Ile 
        195                 200                 205             


Val Ala Gly Gly Phe Leu Ser Lys Ser Leu Val Phe Ser Val Leu Phe 
    210                 215                 220                 


Ala Val Thr Leu Arg Ser Phe Gly Pro 
225                 230             


<210>  8
<211>  196
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptidoglycan recognition protein 1

<400>  8

Met Ser Arg Arg Ser Met Leu Leu Ala Trp Ala Leu Pro Ser Leu Leu 
1               5                   10                  15      


Arg Leu Gly Ala Ala Gln Glu Thr Glu Asp Pro Ala Cys Cys Ser Pro 
            20                  25                  30          


Ile Val Pro Arg Asn Glu Trp Lys Ala Leu Ala Ser Glu Cys Ala Gln 
        35                  40                  45              


His Leu Ser Leu Pro Leu Arg Tyr Val Val Val Ser His Thr Ala Gly 
    50                  55                  60                  


Ser Ser Cys Asn Thr Pro Ala Ser Cys Gln Gln Gln Ala Arg Asn Val 
65                  70                  75                  80  


Gln His Tyr His Met Lys Thr Leu Gly Trp Cys Asp Val Gly Tyr Asn 
                85                  90                  95      


Phe Leu Ile Gly Glu Asp Gly Leu Val Tyr Glu Gly Arg Gly Trp Asn 
            100                 105                 110         


Phe Thr Gly Ala His Ser Gly His Leu Trp Asn Pro Met Ser Ile Gly 
        115                 120                 125             


Ile Ser Phe Met Gly Asn Tyr Met Asp Arg Val Pro Thr Pro Gln Ala 
    130                 135                 140                 


Ile Arg Ala Ala Gln Gly Leu Leu Ala Cys Gly Val Ala Gln Gly Ala 
145                 150                 155                 160 


Leu Arg Ser Asn Tyr Val Leu Lys Gly His Arg Asp Val Gln Arg Thr 
                165                 170                 175     


Leu Ser Pro Gly Asn Gln Leu Tyr His Leu Ile Gln Asn Trp Pro His 
            180                 185                 190         


Tyr Arg Ser Pro 
        195     


<210>  9
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  Wild-type IgG1 Heavy Chain Constant region

<400>  9

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  10
<211>  327
<212>  PRT
<213>  artificial sequence

<220>
<223>  WT IgG4 Heavy Chain Constant Region

<400>  10

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  11
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG1-Aba Heavy Chain Constant Region

<400>  11

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  12
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG4-Aba Heavy Chain Constant Region

<400>  12

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  13
<211>  448
<212>  PRT
<213>  artificial sequence

<220>
<223>  HC of mAb 0170

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445             


<210>  14
<211>  218
<212>  PRT
<213>  artificial sequence

<220>
<223>  LC of mAb 0170

<400>  14

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Asp Thr Phe 
            20                  25                  30          


Asp Tyr Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  15
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH of mAb 0170, 0318

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  16
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL of mAb 0170

<400>  16

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Asp Thr Phe 
            20                  25                  30          


Asp Tyr Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  17
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VH of mAb 0170, 0318

<400>  17

Thr Tyr Ala Met His 
1               5   


<210>  18
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VH of mAb 0170, 0318

<400>  18

Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  19
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VH of mAb 0170, 0318

<400>  19

Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr 
1               5                   10  


<210>  20
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL of mAb 0170

<400>  20

Arg Ala Ser Glu Ser Val Asp Thr Phe Asp Tyr Ser Phe Leu His 
1               5                   10                  15  


<210>  21
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR2 VL of mAb 0170, 0318

<400>  21

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  22
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL of mAb 0170

<400>  22

Gln Gln Ser Asn Glu Asp Pro Tyr Thr 
1               5                   


<210>  23
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL of mAb 0318

<400>  23

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Asp Thr Phe 
            20                  25                  30          


Asp Tyr Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Gln Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  24
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR1 VL of mAb 0318

<400>  24

Arg Ala Ser Gln Ser Val Asp Thr Phe Asp Tyr Ser Phe Leu His 
1               5                   10                  15  


<210>  25
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR3 VL of mAb 0318

<400>  25

Gln Gln Ser Asn Gln Asp Pro Tyr Thr 
1               5                   


<210>  26
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH of 318 Ab - Mutant #1

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Gln Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  27
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH of 318 Ab - Mutant #2

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Leu Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  28
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH of 318 Ab - Mutant #3

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Gln His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  29
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH of 318 Ab - Mutant #4

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Leu His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  30
<211>  451
<212>  PRT
<213>  artificial sequence

<220>
<223>  0318-IgG1.3f HC

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly 
225                 230                 235                 240 


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  31
<211>  450
<212>  PRT
<213>  artificial sequence

<220>
<223>  0318-IgG1.1f HC

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly 
225                 230                 235                 240 


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly 
    450 


<210>  32
<211>  451
<212>  PRT
<213>  artificial sequence

<220>
<223>  0318-IgG1-Aba HC

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  33
<211>  451
<212>  PRT
<213>  artificial sequence

<220>
<223>  0318-IgG4-Aba HC

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  34
<211>  218
<212>  PRT
<213>  artificial sequence

<220>
<223>  0318-IgG1.3f LC; 0318-IgG1.1f LC; 0318-IgG1-Aba LC; 0318-IgG4-Aba
       LC

<400>  34

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Asp Thr Phe 
            20                  25                  30          


Asp Tyr Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Gln Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  35
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG1 kappa light chain

<400>  35

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  36
<211>  1407
<212>  PRT
<213>  artificial sequence

<220>
<223>  0318-IgG1.3f HC

<400>  36

Ala Thr Gly Ala Gly Gly Gly Cys Thr Thr Gly Gly Ala Thr Cys Thr 
1               5                   10                  15      


Thr Cys Thr Thr Thr Cys Thr Gly Cys Thr Cys Thr Gly Cys Cys Thr 
            20                  25                  30          


Gly Gly Cys Cys Gly Gly Gly Cys Gly Cys Gly Cys Cys Thr Thr Gly 
        35                  40                  45              


Gly Cys Cys Gly Ala Ala Gly Thr Gly Cys Ala Gly Cys Thr Cys Gly 
    50                  55                  60                  


Thr Gly Gly Ala Gly Thr Cys Cys Gly Gly Cys Gly Gly Ala Gly Gly 
65                  70                  75                  80  


Ala Cys Thr Gly Gly Thr Cys Cys Ala Ala Cys Cys Thr Gly Gly Cys 
                85                  90                  95      


Gly Gly Cys Thr Cys Cys Cys Thr Gly Ala Ala Gly Cys Thr Gly Thr 
            100                 105                 110         


Cys Cys Thr Gly Cys Gly Cys Thr Gly Cys Cys Thr Cys Cys Gly Gly 
        115                 120                 125             


Cys Thr Thr Cys Ala Cys Cys Thr Thr Cys Thr Cys Cys Ala Cys Cys 
    130                 135                 140                 


Thr Ala Cys Gly Cys Cys Ala Thr Gly Cys Ala Cys Thr Gly Gly Gly 
145                 150                 155                 160 


Thr Cys Ala Gly Gly Cys Ala Gly Gly Cys Cys Thr Cys Cys Gly Gly 
                165                 170                 175     


Ala Ala Ala Gly Gly Gly Cys Cys Thr Gly Gly Ala Ala Thr Gly Gly 
            180                 185                 190         


Gly Thr Cys Gly Gly Cys Cys Gly Gly Ala Thr Thr Ala Gly Gly Ala 
        195                 200                 205             


Cys Cys Ala Ala Gly Thr Cys Cys Ala Gly Cys Ala Ala Cys Thr Ala 
    210                 215                 220                 


Cys Gly Cys Thr Ala Cys Cys Thr Ala Cys Thr Ala Cys Gly Cys Cys 
225                 230                 235                 240 


Gly Cys Cys Ala Gly Cys Gly Thr Cys Ala Ala Gly Gly Gly Cys Cys 
                245                 250                 255     


Gly Gly Thr Thr Cys Ala Cys Ala Ala Thr Cys Thr Cys Cys Cys Gly 
            260                 265                 270         


Gly Gly Ala Cys Gly Ala Cys Thr Cys Cys Ala Ala Gly Ala Ala Cys 
        275                 280                 285             


Ala Cys Cys Gly Cys Cys Thr Ala Thr Cys Thr Cys Cys Ala Gly Ala 
    290                 295                 300                 


Thr Gly Ala Ala Cys Ala Gly Cys Cys Thr Gly Ala Ala Gly Ala Cys 
305                 310                 315                 320 


Ala Gly Ala Gly Gly Ala Cys Ala Cys Cys Gly Cys Cys Gly Thr Gly 
                325                 330                 335     


Thr Ala Cys Thr Ala Thr Thr Gly Cys Ala Cys Cys Cys Gly Gly Gly 
            340                 345                 350         


Ala Thr Ala Thr Gly Gly Gly Cys Ala Thr Thr Cys Gly Gly Ala Gly 
        355                 360                 365             


Gly Cys Ala Gly Thr Thr Cys Gly Cys Cys Thr Ala Thr Thr Gly Gly 
    370                 375                 380                 


Gly Gly Cys Cys Ala Gly Gly Gly Cys Ala Cys Cys Cys Thr Gly Gly 
385                 390                 395                 400 


Thr Gly Ala Cys Ala Gly Thr Cys Ala Gly Cys Thr Cys Cys Gly Cys 
                405                 410                 415     


Cys Ala Gly Cys Ala Cys Ala Ala Ala Ala Gly Gly Ala Cys Cys Thr 
            420                 425                 430         


Ala Gly Cys Gly Thr Gly Thr Thr Cys Cys Cys Cys Cys Thr Gly Gly 
        435                 440                 445             


Cys Cys Cys Cys Thr Ala Gly Cys Ala Gly Cys Ala Ala Gly Thr Cys 
    450                 455                 460                 


Cys Ala Cys Ala Ala Gly Cys Gly Gly Cys Gly Gly Cys Ala Cys Cys 
465                 470                 475                 480 


Gly Cys Thr Gly Cys Cys Cys Thr Gly Gly Gly Cys Thr Gly Thr Cys 
                485                 490                 495     


Thr Gly Gly Thr Gly Ala Ala Ala Gly Ala Cys Thr Ala Cys Thr Thr 
            500                 505                 510         


Thr Cys Cys Cys Gly Ala Gly Cys Cys Cys Gly Thr Gly Ala Cys Ala 
        515                 520                 525             


Gly Thr Gly Ala Gly Cys Thr Gly Gly Ala Ala Cys Thr Cys Thr Gly 
    530                 535                 540                 


Gly Cys Gly Cys Cys Cys Thr Gly Ala Cys Ala Thr Cys Cys Gly Gly 
545                 550                 555                 560 


Ala Gly Thr Gly Cys Ala Cys Ala Cys Cys Thr Thr Cys Cys Cys Thr 
                565                 570                 575     


Gly Cys Cys Gly Thr Gly Cys Thr Cys Cys Ala Gly Thr Cys Cys Ala 
            580                 585                 590         


Gly Cys Gly Gly Cys Cys Thr Gly Thr Ala Cys Ala Gly Cys Cys Thr 
        595                 600                 605             


Gly Ala Gly Cys Ala Gly Cys Gly Thr Cys Gly Thr Gly Ala Cys Cys 
    610                 615                 620                 


Gly Thr Cys Cys Cys Thr Ala Gly Cys Ala Gly Cys Ala Gly Cys Cys 
625                 630                 635                 640 


Thr Gly Gly Gly Ala Ala Cys Cys Cys Ala Gly Ala Cys Cys Thr Ala 
                645                 650                 655     


Cys Ala Thr Cys Thr Gly Cys Ala Ala Cys Gly Thr Gly Ala Ala Cys 
            660                 665                 670         


Cys Ala Cys Ala Ala Gly Cys Cys Cys Thr Cys Cys Ala Ala Cys Ala 
        675                 680                 685             


Cys Cys Ala Ala Gly Gly Thr Gly Gly Ala Cys Ala Ala Gly Ala Gly 
    690                 695                 700                 


Gly Gly Thr Gly Gly Ala Gly Cys Cys Cys Ala Ala Gly Thr Cys Cys 
705                 710                 715                 720 


Thr Gly Thr Gly Ala Cys Ala Ala Gly Ala Cys Cys Cys Ala Thr Ala 
                725                 730                 735     


Cys Cys Thr Gly Cys Cys Cys Cys Cys Cys Cys Thr Gly Thr Cys Cys 
            740                 745                 750         


Thr Gly Cys Thr Cys Cys Thr Gly Ala Ala Gly Cys Thr Gly Ala Gly 
        755                 760                 765             


Gly Gly Cys Gly Cys Cys Cys Cys Thr Thr Cys Cys Gly Thr Cys Thr 
    770                 775                 780                 


Thr Cys Cys Thr Gly Thr Thr Cys Cys Cys Thr Cys Cys Thr Ala Ala 
785                 790                 795                 800 


Gly Cys Cys Cys Ala Ala Gly Gly Ala Cys Ala Cys Cys Cys Thr Gly 
                805                 810                 815     


Ala Thr Gly Ala Thr Cys Thr Cys Cys Ala Gly Gly Ala Cys Cys Cys 
            820                 825                 830         


Cys Cys Gly Ala Gly Gly Thr Gly Ala Cys Cys Thr Gly Thr Gly Thr 
        835                 840                 845             


Gly Gly Thr Gly Gly Thr Gly Gly Ala Thr Gly Thr Gly Thr Cys Cys 
    850                 855                 860                 


Cys Ala Cys Gly Ala Gly Gly Ala Cys Cys Cys Cys Gly Ala Gly Gly 
865                 870                 875                 880 


Thr Gly Ala Ala Gly Thr Thr Cys Ala Ala Thr Thr Gly Gly Thr Ala 
                885                 890                 895     


Cys Gly Thr Cys Gly Ala Cys Gly Gly Cys Gly Thr Gly Gly Ala Gly 
            900                 905                 910         


Gly Thr Gly Cys Ala Cys Ala Ala Cys Gly Cys Cys Ala Ala Gly Ala 
        915                 920                 925             


Cys Cys Ala Ala Ala Cys Cys Cys Cys Gly Gly Gly Ala Gly Gly Ala 
    930                 935                 940                 


Gly Cys Ala Gly Thr Ala Thr Ala Ala Cys Ala Gly Cys Ala Cys Cys 
945                 950                 955                 960 


Thr Ala Cys Cys Gly Gly Gly Thr Gly Gly Thr Gly Thr Cys Cys Gly 
                965                 970                 975     


Thr Gly Cys Thr Cys Ala Cys Cys Gly Thr Gly Cys Thr Gly Cys Ala 
            980                 985                 990         


Cys Cys Ala Gly Gly Ala Cys Thr  Gly Gly Cys Thr Gly  Ala Ala Cys 
        995                 1000                 1005             


Gly Gly  Cys Ala Ala Gly Gly  Ala Gly Thr Ala Cys  Ala Ala Gly 
    1010                 1015                 1020             


Thr Gly  Thr Ala Ala Gly Gly  Thr Cys Ala Gly Cys  Ala Ala Thr 
    1025                 1030                 1035             


Ala Ala  Gly Gly Cys Cys Cys  Thr Gly Cys Cys Thr  Gly Cys Cys 
    1040                 1045                 1050             


Cys Cys  Cys Ala Thr Cys Gly  Ala Gly Ala Ala Gly  Ala Cys Cys 
    1055                 1060                 1065             


Ala Thr  Thr Ala Gly Cys Ala  Ala Gly Gly Cys Thr  Ala Ala Gly 
    1070                 1075                 1080             


Gly Gly  Cys Cys Ala Gly Cys  Cys Cys Ala Gly Gly  Gly Ala Ala 
    1085                 1090                 1095             


Cys Cys  Cys Cys Ala Gly Gly  Thr Gly Thr Ala Thr  Ala Cys Cys 
    1100                 1105                 1110             


Cys Thr  Cys Cys Cys Cys Cys  Cys Thr Ala Gly Cys  Cys Gly Gly 
    1115                 1120                 1125             


Gly Ala  Gly Gly Ala Gly Ala  Thr Gly Ala Cys Cys  Ala Ala Gly 
    1130                 1135                 1140             


Ala Ala  Cys Cys Ala Gly Gly  Thr Cys Ala Gly Cys  Cys Thr Gly 
    1145                 1150                 1155             


Ala Cys  Cys Thr Gly Cys Cys  Thr Gly Gly Thr Gly  Ala Ala Ala 
    1160                 1165                 1170             


Gly Gly  Ala Thr Thr Cys Thr  Ala Cys Cys Cys Thr  Ala Gly Cys 
    1175                 1180                 1185             


Gly Ala  Cys Ala Thr Cys Gly  Cys Thr Gly Thr Gly  Gly Ala Gly 
    1190                 1195                 1200             


Thr Gly  Gly Gly Ala Gly Ala  Gly Cys Ala Ala Thr  Gly Gly Ala 
    1205                 1210                 1215             


Cys Ala  Gly Cys Cys Cys Gly  Ala Gly Ala Ala Cys  Ala Ala Cys 
    1220                 1225                 1230             


Thr Ala  Cys Ala Ala Ala Ala  Cys Cys Ala Cys Cys  Cys Cys Thr 
    1235                 1240                 1245             


Cys Cys  Cys Gly Thr Cys Cys  Thr Gly Gly Ala Cys  Thr Cys Cys 
    1250                 1255                 1260             


Gly Ala  Thr Gly Gly Cys Ala  Gly Cys Thr Thr Cys  Thr Thr Thr 
    1265                 1270                 1275             


Cys Thr  Gly Thr Ala Cys Thr  Cys Cys Ala Ala Gly  Cys Thr Cys 
    1280                 1285                 1290             


Ala Cys  Cys Gly Thr Cys Gly  Ala Cys Ala Ala Gly  Ala Gly Cys 
    1295                 1300                 1305             


Cys Gly  Gly Thr Gly Gly Cys  Ala Gly Cys Ala Gly  Gly Gly Cys 
    1310                 1315                 1320             


Ala Ala  Thr Gly Thr Gly Thr  Thr Thr Ala Gly Cys  Thr Gly Cys 
    1325                 1330                 1335             


Thr Cys  Cys Gly Thr Gly Ala  Thr Gly Cys Ala Cys  Gly Ala Gly 
    1340                 1345                 1350             


Gly Cys  Thr Cys Thr Gly Cys  Ala Cys Ala Ala Cys  Cys Ala Cys 
    1355                 1360                 1365             


Thr Ala  Thr Ala Cys Cys Cys  Ala Ala Ala Ala Gly  Thr Cys Cys 
    1370                 1375                 1380             


Cys Thr  Gly Thr Cys Cys Cys  Thr Cys Ala Gly Cys  Cys Cys Cys 
    1385                 1390                 1395             


Gly Gly  Cys Ala Ala Gly Thr  Gly Ala 
    1400                 1405         


<210>  37
<211>  1404
<212>  PRT
<213>  artificial sequence

<220>
<223>  0318-IgG1.1f HC

<400>  37

Ala Thr Gly Ala Gly Gly Gly Cys Thr Thr Gly Gly Ala Thr Cys Thr 
1               5                   10                  15      


Thr Cys Thr Thr Thr Cys Thr Gly Cys Thr Cys Thr Gly Cys Cys Thr 
            20                  25                  30          


Gly Gly Cys Cys Gly Gly Gly Cys Gly Cys Gly Cys Cys Thr Thr Gly 
        35                  40                  45              


Gly Cys Cys Gly Ala Ala Gly Thr Gly Cys Ala Gly Cys Thr Gly Gly 
    50                  55                  60                  


Thr Gly Gly Ala Ala Ala Gly Cys Gly Gly Cys Gly Gly Ala Gly Gly 
65                  70                  75                  80  


Ala Cys Thr Gly Gly Thr Gly Cys Ala Gly Cys Cys Ala Gly Gly Cys 
                85                  90                  95      


Gly Gly Cys Ala Gly Cys Cys Thr Gly Ala Ala Gly Cys Thr Gly Thr 
            100                 105                 110         


Cys Thr Thr Gly Cys Gly Cys Cys Gly Cys Cys Ala Gly Cys Gly Gly 
        115                 120                 125             


Cys Thr Thr Cys Ala Cys Cys Thr Thr Cys Ala Gly Cys Ala Cys Cys 
    130                 135                 140                 


Thr Ala Cys Gly Cys Cys Ala Thr Gly Cys Ala Cys Thr Gly Gly Gly 
145                 150                 155                 160 


Thr Cys Cys Gly Cys Cys Ala Gly Gly Cys Cys Ala Gly Cys Gly Gly 
                165                 170                 175     


Cys Ala Ala Gly Gly Gly Cys Cys Thr Gly Gly Ala Ala Thr Gly Gly 
            180                 185                 190         


Gly Thr Cys Gly Gly Ala Cys Gly Gly Ala Thr Cys Cys Gly Gly Ala 
        195                 200                 205             


Cys Cys Ala Ala Gly Ala Gly Cys Ala Gly Cys Ala Ala Cys Thr Ala 
    210                 215                 220                 


Cys Gly Cys Cys Ala Cys Cys Thr Ala Cys Thr Ala Cys Gly Cys Cys 
225                 230                 235                 240 


Gly Cys Cys Thr Cys Cys Gly Thr Gly Ala Ala Gly Gly Gly Cys Cys 
                245                 250                 255     


Gly Gly Thr Thr Cys Ala Cys Cys Ala Thr Cys Ala Gly Cys Cys Gly 
            260                 265                 270         


Gly Gly Ala Cys Gly Ala Cys Ala Gly Cys Ala Ala Gly Ala Ala Cys 
        275                 280                 285             


Ala Cys Cys Gly Cys Cys Thr Ala Cys Cys Thr Gly Cys Ala Gly Ala 
    290                 295                 300                 


Thr Gly Ala Ala Cys Ala Gly Cys Cys Thr Gly Ala Ala Ala Ala Cys 
305                 310                 315                 320 


Cys Gly Ala Gly Gly Ala Cys Ala Cys Cys Gly Cys Cys Gly Thr Gly 
                325                 330                 335     


Thr Ala Cys Thr Ala Cys Thr Gly Cys Ala Cys Cys Cys Gly Gly Gly 
            340                 345                 350         


Ala Cys Ala Thr Gly Gly Gly Cys Ala Thr Cys Cys Gly Gly Cys Gly 
        355                 360                 365             


Gly Cys Ala Gly Thr Thr Thr Gly Cys Cys Thr Ala Cys Thr Gly Gly 
    370                 375                 380                 


Gly Gly Cys Cys Ala Gly Gly Gly Cys Ala Cys Cys Cys Thr Gly Gly 
385                 390                 395                 400 


Thr Cys Ala Cys Ala Gly Thr Gly Thr Cys Cys Ala Gly Cys Gly Cys 
                405                 410                 415     


Gly Thr Cys Gly Ala Cys Cys Ala Ala Gly Gly Gly Cys Cys Cys Ala 
            420                 425                 430         


Thr Cys Gly Gly Thr Cys Thr Thr Cys Cys Cys Cys Cys Thr Gly Gly 
        435                 440                 445             


Cys Ala Cys Cys Cys Thr Cys Cys Thr Cys Cys Ala Ala Gly Ala Gly 
    450                 455                 460                 


Cys Ala Cys Cys Thr Cys Thr Gly Gly Gly Gly Gly Cys Ala Cys Ala 
465                 470                 475                 480 


Gly Cys Gly Gly Cys Cys Cys Thr Gly Gly Gly Cys Thr Gly Cys Cys 
                485                 490                 495     


Thr Gly Gly Thr Cys Ala Ala Gly Gly Ala Cys Thr Ala Cys Thr Thr 
            500                 505                 510         


Cys Cys Cys Cys Gly Ala Ala Cys Cys Gly Gly Thr Gly Ala Cys Gly 
        515                 520                 525             


Gly Thr Gly Thr Cys Gly Thr Gly Gly Ala Ala Cys Thr Cys Ala Gly 
    530                 535                 540                 


Gly Cys Gly Cys Cys Cys Thr Gly Ala Cys Cys Ala Gly Cys Gly Gly 
545                 550                 555                 560 


Cys Gly Thr Gly Cys Ala Cys Ala Cys Cys Thr Thr Cys Cys Cys Gly 
                565                 570                 575     


Gly Cys Thr Gly Thr Cys Cys Thr Ala Cys Ala Gly Thr Cys Cys Thr 
            580                 585                 590         


Cys Ala Gly Gly Ala Cys Thr Cys Thr Ala Cys Thr Cys Cys Cys Thr 
        595                 600                 605             


Cys Ala Gly Cys Ala Gly Cys Gly Thr Gly Gly Thr Gly Ala Cys Cys 
    610                 615                 620                 


Gly Thr Gly Cys Cys Cys Thr Cys Cys Ala Gly Cys Ala Gly Cys Thr 
625                 630                 635                 640 


Thr Gly Gly Gly Cys Ala Cys Cys Cys Ala Gly Ala Cys Cys Thr Ala 
                645                 650                 655     


Cys Ala Thr Cys Thr Gly Cys Ala Ala Cys Gly Thr Gly Ala Ala Thr 
            660                 665                 670         


Cys Ala Cys Ala Ala Gly Cys Cys Cys Ala Gly Cys Ala Ala Cys Ala 
        675                 680                 685             


Cys Cys Ala Ala Gly Gly Thr Gly Gly Ala Cys Ala Ala Gly Ala Gly 
    690                 695                 700                 


Ala Gly Thr Thr Gly Ala Gly Cys Cys Cys Ala Ala Ala Thr Cys Thr 
705                 710                 715                 720 


Thr Gly Thr Gly Ala Cys Ala Ala Ala Ala Cys Thr Cys Ala Cys Ala 
                725                 730                 735     


Cys Ala Thr Gly Cys Cys Cys Ala Cys Cys Gly Thr Gly Cys Cys Cys 
            740                 745                 750         


Ala Gly Cys Ala Cys Cys Thr Gly Ala Ala Gly Cys Cys Gly Ala Ala 
        755                 760                 765             


Gly Gly Gly Gly Cys Cys Cys Cys Gly Thr Cys Ala Gly Thr Cys Thr 
    770                 775                 780                 


Thr Cys Cys Thr Cys Thr Thr Cys Cys Cys Cys Cys Cys Ala Ala Ala 
785                 790                 795                 800 


Ala Cys Cys Cys Ala Ala Gly Gly Ala Cys Ala Cys Cys Cys Thr Cys 
                805                 810                 815     


Ala Thr Gly Ala Thr Cys Thr Cys Cys Cys Gly Gly Ala Cys Cys Cys 
            820                 825                 830         


Cys Thr Gly Ala Gly Gly Thr Cys Ala Cys Ala Thr Gly Cys Gly Thr 
        835                 840                 845             


Gly Gly Thr Gly Gly Thr Gly Gly Ala Cys Gly Thr Gly Ala Gly Cys 
    850                 855                 860                 


Cys Ala Cys Gly Ala Ala Gly Ala Cys Cys Cys Thr Gly Ala Gly Gly 
865                 870                 875                 880 


Thr Cys Ala Ala Gly Thr Thr Cys Ala Ala Cys Thr Gly Gly Thr Ala 
                885                 890                 895     


Cys Gly Thr Gly Gly Ala Cys Gly Gly Cys Gly Thr Gly Gly Ala Gly 
            900                 905                 910         


Gly Thr Gly Cys Ala Thr Ala Ala Thr Gly Cys Cys Ala Ala Gly Ala 
        915                 920                 925             


Cys Ala Ala Ala Gly Cys Cys Gly Cys Gly Gly Gly Ala Gly Gly Ala 
    930                 935                 940                 


Gly Cys Ala Gly Thr Ala Cys Ala Ala Cys Ala Gly Cys Ala Cys Gly 
945                 950                 955                 960 


Thr Ala Cys Cys Gly Thr Gly Thr Gly Gly Thr Cys Ala Gly Cys Gly 
                965                 970                 975     


Thr Cys Cys Thr Cys Ala Cys Cys Gly Thr Cys Cys Thr Gly Cys Ala 
            980                 985                 990         


Cys Cys Ala Gly Gly Ala Cys Thr  Gly Gly Cys Thr Gly  Ala Ala Thr 
        995                 1000                 1005             


Gly Gly  Cys Ala Ala Gly Gly  Ala Gly Thr Ala Cys  Ala Ala Gly 
    1010                 1015                 1020             


Thr Gly  Cys Ala Ala Gly Gly  Thr Cys Thr Cys Cys  Ala Ala Cys 
    1025                 1030                 1035             


Ala Ala  Ala Gly Cys Cys Cys  Thr Cys Cys Cys Ala  Ala Gly Cys 
    1040                 1045                 1050             


Ala Gly  Cys Ala Thr Cys Gly  Ala Gly Ala Ala Ala  Ala Cys Cys 
    1055                 1060                 1065             


Ala Thr  Cys Thr Cys Cys Ala  Ala Ala Gly Cys Cys  Ala Ala Ala 
    1070                 1075                 1080             


Gly Gly  Gly Cys Ala Gly Cys  Cys Cys Cys Gly Ala  Gly Ala Ala 
    1085                 1090                 1095             


Cys Cys  Ala Cys Ala Gly Gly  Thr Gly Thr Ala Cys  Ala Cys Cys 
    1100                 1105                 1110             


Cys Thr  Gly Cys Cys Cys Cys  Cys Ala Thr Cys Cys  Cys Gly Gly 
    1115                 1120                 1125             


Gly Ala  Gly Gly Ala Gly Ala  Thr Gly Ala Cys Cys  Ala Ala Gly 
    1130                 1135                 1140             


Ala Ala  Cys Cys Ala Gly Gly  Thr Cys Ala Gly Cys  Cys Thr Gly 
    1145                 1150                 1155             


Ala Cys  Cys Thr Gly Cys Cys  Thr Gly Gly Thr Cys  Ala Ala Ala 
    1160                 1165                 1170             


Gly Gly  Cys Thr Thr Cys Thr  Ala Thr Cys Cys Cys  Ala Gly Cys 
    1175                 1180                 1185             


Gly Ala  Cys Ala Thr Cys Gly  Cys Cys Gly Thr Gly  Gly Ala Gly 
    1190                 1195                 1200             


Thr Gly  Gly Gly Ala Gly Ala  Gly Cys Ala Ala Thr  Gly Gly Gly 
    1205                 1210                 1215             


Cys Ala  Gly Cys Cys Gly Gly  Ala Gly Ala Ala Cys  Ala Ala Cys 
    1220                 1225                 1230             


Thr Ala  Cys Ala Ala Gly Ala  Cys Cys Ala Cys Gly  Cys Cys Thr 
    1235                 1240                 1245             


Cys Cys  Cys Gly Thr Gly Cys  Thr Gly Gly Ala Cys  Thr Cys Cys 
    1250                 1255                 1260             


Gly Ala  Cys Gly Gly Cys Thr  Cys Cys Thr Thr Cys  Thr Thr Cys 
    1265                 1270                 1275             


Cys Thr  Cys Thr Ala Thr Ala  Gly Cys Ala Ala Gly  Cys Thr Cys 
    1280                 1285                 1290             


Ala Cys  Cys Gly Thr Gly Gly  Ala Cys Ala Ala Gly  Ala Gly Cys 
    1295                 1300                 1305             


Ala Gly  Gly Thr Gly Gly Cys  Ala Gly Cys Ala Gly  Gly Gly Gly 
    1310                 1315                 1320             


Ala Ala  Cys Gly Thr Cys Thr  Thr Cys Thr Cys Ala  Thr Gly Cys 
    1325                 1330                 1335             


Thr Cys  Cys Gly Thr Gly Ala  Thr Gly Cys Ala Thr  Gly Ala Gly 
    1340                 1345                 1350             


Gly Cys  Thr Cys Thr Gly Cys  Ala Cys Ala Ala Cys  Cys Ala Cys 
    1355                 1360                 1365             


Thr Ala  Cys Ala Cys Gly Cys  Ala Gly Ala Ala Gly  Ala Gly Cys 
    1370                 1375                 1380             


Cys Thr  Cys Thr Cys Cys Cys  Thr Gly Thr Cys Cys  Cys Cys Gly 
    1385                 1390                 1395             


Gly Gly  Thr Thr Gly Ala 
    1400                 


<210>  38
<211>  1407
<212>  PRT
<213>  artificial sequence

<220>
<223>  0318-IgG1-Aba HC

<400>  38

Ala Thr Gly Ala Gly Gly Gly Cys Thr Thr Gly Gly Ala Thr Cys Thr 
1               5                   10                  15      


Thr Cys Thr Thr Thr Cys Thr Gly Cys Thr Cys Thr Gly Cys Cys Thr 
            20                  25                  30          


Gly Gly Cys Cys Gly Gly Gly Cys Gly Cys Gly Cys Cys Thr Thr Gly 
        35                  40                  45              


Gly Cys Cys Gly Ala Gly Gly Thr Cys Cys Ala Gly Cys Thr Gly Gly 
    50                  55                  60                  


Thr Gly Gly Ala Gly Ala Gly Cys Gly Gly Ala Gly Gly Ala Gly Gly 
65                  70                  75                  80  


Ala Cys Thr Cys Gly Thr Gly Cys Ala Gly Cys Cys Thr Gly Gly Ala 
                85                  90                  95      


Gly Gly Ala Thr Cys Cys Cys Thr Gly Ala Ala Gly Cys Thr Gly Thr 
            100                 105                 110         


Cys Cys Thr Gly Cys Gly Cys Thr Gly Cys Cys Thr Cys Cys Gly Gly 
        115                 120                 125             


Cys Thr Thr Thr Ala Cys Cys Thr Thr Cys Thr Cys Cys Ala Cys Cys 
    130                 135                 140                 


Thr Ala Cys Gly Cys Cys Ala Thr Gly Cys Ala Thr Thr Gly Gly Gly 
145                 150                 155                 160 


Thr Gly Ala Gly Gly Cys Ala Gly Gly Cys Cys Thr Cys Cys Gly Gly 
                165                 170                 175     


Cys Ala Ala Gly Gly Gly Cys Cys Thr Gly Gly Ala Ala Thr Gly Gly 
            180                 185                 190         


Gly Thr Gly Gly Gly Cys Ala Gly Gly Ala Thr Cys Ala Gly Gly Ala 
        195                 200                 205             


Cys Ala Ala Ala Gly Ala Gly Cys Thr Cys Cys Ala Ala Cys Thr Ala 
    210                 215                 220                 


Cys Gly Cys Cys Ala Cys Cys Thr Ala Cys Thr Ala Cys Gly Cys Cys 
225                 230                 235                 240 


Gly Cys Cys Ala Gly Cys Gly Thr Gly Ala Ala Ala Gly Gly Ala Cys 
                245                 250                 255     


Gly Gly Thr Thr Cys Ala Cys Cys Ala Thr Cys Thr Cys Cys Cys Gly 
            260                 265                 270         


Gly Gly Ala Cys Gly Ala Thr Thr Cys Cys Ala Ala Ala Ala Ala Cys 
        275                 280                 285             


Ala Cys Cys Gly Cys Cys Thr Ala Cys Cys Thr Cys Cys Ala Gly Ala 
    290                 295                 300                 


Thr Gly Ala Ala Thr Ala Gly Cys Cys Thr Gly Ala Ala Gly Ala Cys 
305                 310                 315                 320 


Cys Gly Ala Gly Gly Ala Cys Ala Cys Cys Gly Cys Cys Gly Thr Cys 
                325                 330                 335     


Thr Ala Cys Thr Ala Cys Thr Gly Cys Ala Cys Cys Ala Gly Gly Gly 
            340                 345                 350         


Ala Thr Ala Thr Gly Gly Gly Cys Ala Thr Cys Cys Gly Gly Cys Gly 
        355                 360                 365             


Gly Cys Ala Gly Thr Thr Thr Gly Cys Cys Thr Ala Cys Thr Gly Gly 
    370                 375                 380                 


Gly Gly Cys Cys Ala Gly Gly Gly Cys Ala Cys Cys Cys Thr Gly Gly 
385                 390                 395                 400 


Thr Gly Ala Cys Ala Gly Thr Gly Thr Cys Cys Ala Gly Cys Gly Cys 
                405                 410                 415     


Thr Ala Gly Cys Ala Cys Cys Ala Ala Ala Gly Gly Cys Cys Cys Cys 
            420                 425                 430         


Thr Cys Cys Gly Thr Gly Thr Thr Cys Cys Cys Cys Cys Thr Gly Gly 
        435                 440                 445             


Cys Thr Cys Cys Cys Thr Cys Cys Ala Gly Cys Ala Ala Gly Thr Cys 
    450                 455                 460                 


Cys Ala Cys Ala Thr Cys Cys Gly Gly Cys Gly Gly Ala Ala Cys Cys 
465                 470                 475                 480 


Gly Cys Cys Gly Cys Thr Cys Thr Gly Gly Gly Ala Thr Gly Thr Cys 
                485                 490                 495     


Thr Gly Gly Thr Gly Ala Ala Gly Gly Ala Cys Thr Ala Cys Thr Thr 
            500                 505                 510         


Cys Cys Cys Cys Gly Ala Gly Cys Cys Cys Gly Thr Gly Ala Cys Ala 
        515                 520                 525             


Gly Thr Gly Ala Gly Cys Thr Gly Gly Ala Ala Cys Thr Cys Thr Gly 
    530                 535                 540                 


Gly Cys Gly Cys Thr Cys Thr Gly Ala Cys Cys Thr Cys Cys Gly Gly 
545                 550                 555                 560 


Cys Gly Thr Gly Cys Ala Cys Ala Cys Cys Thr Thr Thr Cys Cys Thr 
                565                 570                 575     


Gly Cys Thr Gly Thr Gly Cys Thr Gly Cys Ala Gly Thr Cys Cys Thr 
            580                 585                 590         


Cys Cys Gly Gly Cys Cys Thr Cys Thr Ala Cys Ala Gly Cys Cys Thr 
        595                 600                 605             


Gly Thr Cys Cys Thr Cys Cys Gly Thr Cys Gly Thr Gly Ala Cys Ala 
    610                 615                 620                 


Gly Thr Gly Cys Cys Cys Thr Cys Cys Thr Cys Cys Ala Gly Cys Cys 
625                 630                 635                 640 


Thr Gly Gly Gly Cys Ala Cys Cys Cys Ala Gly Ala Cys Cys Thr Ala 
                645                 650                 655     


Cys Ala Thr Cys Thr Gly Cys Ala Ala Cys Gly Thr Gly Ala Ala Cys 
            660                 665                 670         


Cys Ala Cys Ala Ala Gly Cys Cys Thr Thr Cys Cys Ala Ala Cys Ala 
        675                 680                 685             


Cys Cys Ala Ala Gly Gly Thr Gly Gly Ala Thr Ala Ala Gly Cys Gly 
    690                 695                 700                 


Gly Gly Thr Cys Gly Ala Ala Cys Cys Cys Ala Ala Gly Ala Gly Cys 
705                 710                 715                 720 


Thr Gly Cys Gly Ala Cys Ala Ala Gly Ala Cys Cys Cys Ala Cys Ala 
                725                 730                 735     


Cys Cys Ala Gly Cys Cys Cys Cys Cys Cys Thr Thr Cys Cys Cys Cys 
            740                 745                 750         


Thr Gly Cys Thr Cys Cys Cys Gly Ala Gly Cys Thr Cys Cys Thr Gly 
        755                 760                 765             


Gly Gly Ala Gly Gly Cys Ala Gly Cys Thr Cys Cys Gly Thr Gly Thr 
    770                 775                 780                 


Thr Thr Cys Thr Gly Thr Thr Thr Cys Cys Cys Cys Cys Cys Ala Ala 
785                 790                 795                 800 


Gly Cys Cys Thr Ala Ala Gly Gly Ala Cys Ala Cys Cys Cys Thr Gly 
                805                 810                 815     


Ala Thr Gly Ala Thr Cys Ala Gly Cys Ala Gly Gly Ala Cys Cys Cys 
            820                 825                 830         


Cys Cys Gly Ala Ala Gly Thr Gly Ala Cys Ala Thr Gly Cys Gly Thr 
        835                 840                 845             


Gly Gly Thr Gly Gly Thr Cys Gly Ala Cys Gly Thr Gly Thr Cys Cys 
    850                 855                 860                 


Cys Ala Cys Gly Ala Gly Gly Ala Cys Cys Cys Cys Gly Ala Gly Gly 
865                 870                 875                 880 


Thr Cys Ala Ala Gly Thr Thr Cys Ala Ala Cys Thr Gly Gly Thr Ala 
                885                 890                 895     


Cys Gly Thr Gly Gly Ala Thr Gly Gly Ala Gly Thr Gly Gly Ala Gly 
            900                 905                 910         


Gly Thr Cys Cys Ala Thr Ala Ala Thr Gly Cys Cys Ala Ala Gly Ala 
        915                 920                 925             


Cys Cys Ala Ala Gly Cys Cys Cys Cys Gly Gly Gly Ala Gly Gly Ala 
    930                 935                 940                 


Gly Cys Ala Gly Thr Ala Cys Ala Ala Thr Thr Cys Cys Ala Cys Cys 
945                 950                 955                 960 


Thr Ala Cys Cys Gly Gly Gly Thr Gly Gly Thr Gly Thr Cys Cys Gly 
                965                 970                 975     


Thr Gly Cys Thr Gly Ala Cys Ala Gly Thr Cys Cys Thr Gly Cys Ala 
            980                 985                 990         


Thr Cys Ala Gly Gly Ala Cys Thr  Gly Gly Cys Thr Cys  Ala Ala Cys 
        995                 1000                 1005             


Gly Gly  Cys Ala Ala Gly Gly  Ala Gly Thr Ala Cys  Ala Ala Ala 
    1010                 1015                 1020             


Thr Gly  Cys Ala Ala Gly Gly  Thr Gly Thr Cys Cys  Ala Ala Cys 
    1025                 1030                 1035             


Ala Ala  Gly Gly Cys Thr Cys  Thr Gly Cys Cys Cys  Gly Cys Cys 
    1040                 1045                 1050             


Cys Cys  Cys Ala Thr Cys Gly  Ala Gly Ala Ala Gly  Ala Cys Ala 
    1055                 1060                 1065             


Ala Thr  Cys Ala Gly Cys Ala  Ala Gly Gly Cys Thr  Ala Ala Gly 
    1070                 1075                 1080             


Gly Gly  Cys Cys Ala Gly Cys  Cys Thr Ala Gly Gly  Gly Ala Gly 
    1085                 1090                 1095             


Cys Cys  Cys Cys Ala Gly Gly  Thr Gly Thr Ala Cys  Ala Cys Cys 
    1100                 1105                 1110             


Cys Thr  Gly Cys Cys Cys Cys  Cys Thr Thr Cys Cys  Ala Gly Gly 
    1115                 1120                 1125             


Gly Ala  Cys Gly Ala Gly Cys  Thr Cys Ala Cys Cys  Ala Ala Gly 
    1130                 1135                 1140             


Ala Ala  Cys Cys Ala Gly Gly  Thr Gly Thr Cys Cys  Cys Thr Gly 
    1145                 1150                 1155             


Ala Cys  Ala Thr Gly Cys Cys  Thr Cys Gly Thr Gly  Ala Ala Gly 
    1160                 1165                 1170             


Gly Gly  Cys Thr Thr Thr Thr  Ala Cys Cys Cys Thr  Ala Gly Cys 
    1175                 1180                 1185             


Gly Ala  Cys Ala Thr Cys Gly  Cys Thr Gly Thr Gly  Gly Ala Gly 
    1190                 1195                 1200             


Thr Gly  Gly Gly Ala Gly Thr  Cys Cys Ala Ala Cys  Gly Gly Ala 
    1205                 1210                 1215             


Cys Ala  Gly Cys Cys Cys Gly  Ala Gly Ala Ala Cys  Ala Ala Cys 
    1220                 1225                 1230             


Thr Ala  Cys Ala Ala Gly Ala  Cys Ala Ala Cys Ala  Cys Cys Cys 
    1235                 1240                 1245             


Cys Cys  Thr Gly Thr Gly Cys  Thr Gly Gly Ala Cys  Thr Cys Cys 
    1250                 1255                 1260             


Gly Ala  Cys Gly Gly Cys Thr  Cys Cys Thr Thr Cys  Thr Thr Cys 
    1265                 1270                 1275             


Cys Thr  Gly Thr Ala Cys Ala  Gly Cys Ala Ala Gly  Cys Thr Cys 
    1280                 1285                 1290             


Ala Cys  Cys Gly Thr Gly Gly  Ala Cys Ala Ala Ala  Thr Cys Cys 
    1295                 1300                 1305             


Cys Gly  Gly Thr Gly Gly Cys  Ala Gly Cys Ala Gly  Gly Gly Ala 
    1310                 1315                 1320             


Ala Ala  Cys Gly Thr Gly Thr  Thr Cys Ala Gly Cys  Thr Gly Cys 
    1325                 1330                 1335             


Thr Cys  Cys Gly Thr Gly Ala  Thr Gly Cys Ala Thr  Gly Ala Gly 
    1340                 1345                 1350             


Gly Cys  Cys Cys Thr Gly Cys  Ala Cys Ala Ala Cys  Cys Ala Thr 
    1355                 1360                 1365             


Thr Ala  Cys Ala Cys Cys Cys  Ala Gly Ala Ala Ala  Thr Cys Cys 
    1370                 1375                 1380             


Cys Thr  Gly Thr Cys Cys Cys  Thr Gly Thr Cys Cys  Cys Cys Cys 
    1385                 1390                 1395             


Gly Gly  Cys Ala Ala Gly Thr  Gly Ala 
    1400                 1405         


<210>  39
<211>  1407
<212>  PRT
<213>  artificial sequence

<220>
<223>  0318-IgG4-Aba HC

<400>  39

Ala Thr Gly Ala Gly Gly Gly Cys Thr Thr Gly Gly Ala Thr Cys Thr 
1               5                   10                  15      


Thr Cys Thr Thr Thr Cys Thr Gly Cys Thr Cys Thr Gly Cys Cys Thr 
            20                  25                  30          


Gly Gly Cys Cys Gly Gly Gly Cys Gly Cys Gly Cys Cys Thr Thr Gly 
        35                  40                  45              


Gly Cys Cys Gly Ala Gly Gly Thr Cys Cys Ala Gly Cys Thr Gly Gly 
    50                  55                  60                  


Thr Cys Gly Ala Gly Ala Gly Cys Gly Gly Cys Gly Gly Ala Gly Gly 
65                  70                  75                  80  


Ala Cys Thr Gly Gly Thr Cys Cys Ala Gly Cys Cys Thr Gly Gly Ala 
                85                  90                  95      


Gly Gly Ala Thr Cys Cys Cys Thr Gly Ala Ala Gly Cys Thr Cys Thr 
            100                 105                 110         


Cys Cys Thr Gly Thr Gly Cys Cys Gly Cys Thr Ala Gly Cys Gly Gly 
        115                 120                 125             


Ala Thr Thr Thr Ala Cys Cys Thr Thr Cys Ala Gly Cys Ala Cys Cys 
    130                 135                 140                 


Thr Ala Cys Gly Cys Thr Ala Thr Gly Cys Ala Thr Thr Gly Gly Gly 
145                 150                 155                 160 


Thr Gly Ala Gly Gly Cys Ala Gly Gly Cys Thr Thr Cys Cys Gly Gly 
                165                 170                 175     


Cys Ala Ala Gly Gly Gly Ala Cys Thr Gly Gly Ala Gly Thr Gly Gly 
            180                 185                 190         


Gly Thr Gly Gly Gly Ala Cys Gly Gly Ala Thr Thr Cys Gly Gly Ala 
        195                 200                 205             


Cys Cys Ala Ala Gly Ala Gly Cys Thr Cys Cys Ala Ala Thr Thr Ala 
    210                 215                 220                 


Cys Gly Cys Cys Ala Cys Cys Thr Ala Thr Thr Ala Cys Gly Cys Cys 
225                 230                 235                 240 


Gly Cys Thr Thr Cys Cys Gly Thr Gly Ala Ala Gly Gly Gly Cys Cys 
                245                 250                 255     


Gly Gly Thr Thr Cys Ala Cys Cys Ala Thr Cys Thr Cys Cys Ala Gly 
            260                 265                 270         


Gly Gly Ala Cys Gly Ala Cys Thr Cys Cys Ala Ala Gly Ala Ala Cys 
        275                 280                 285             


Ala Cys Cys Gly Cys Thr Thr Ala Cys Cys Thr Gly Cys Ala Gly Ala 
    290                 295                 300                 


Thr Gly Ala Ala Cys Thr Cys Cys Cys Thr Cys Ala Ala Gly Ala Cys 
305                 310                 315                 320 


Cys Gly Ala Gly Gly Ala Cys Ala Cys Cys Gly Cys Cys Gly Thr Gly 
                325                 330                 335     


Thr Ala Thr Thr Ala Cys Thr Gly Cys Ala Cys Cys Cys Gly Gly Gly 
            340                 345                 350         


Ala Cys Ala Thr Gly Gly Gly Cys Ala Thr Cys Cys Gly Gly Ala Gly 
        355                 360                 365             


Gly Cys Ala Gly Thr Thr Cys Gly Cys Thr Thr Ala Thr Thr Gly Gly 
    370                 375                 380                 


Gly Gly Ala Cys Ala Gly Gly Gly Cys Ala Cys Cys Cys Thr Gly Gly 
385                 390                 395                 400 


Thr Gly Ala Cys Cys Gly Thr Gly Ala Gly Cys Thr Cys Cys Gly Cys 
                405                 410                 415     


Cys Thr Cys Cys Ala Cys Cys Ala Ala Gly Gly Gly Cys Cys Cys Thr 
            420                 425                 430         


Thr Cys Cys Gly Thr Gly Thr Thr Cys Cys Cys Thr Cys Thr Gly Gly 
        435                 440                 445             


Cys Cys Cys Cys Cys Thr Gly Thr Ala Gly Cys Ala Gly Gly Thr Cys 
    450                 455                 460                 


Cys Ala Cys Cys Ala Gly Cys Gly Ala Gly Thr Cys Cys Ala Cys Ala 
465                 470                 475                 480 


Gly Cys Thr Gly Cys Thr Cys Thr Gly Gly Gly Cys Thr Gly Thr Cys 
                485                 490                 495     


Thr Gly Gly Thr Gly Ala Ala Gly Gly Ala Thr Thr Ala Thr Thr Thr 
            500                 505                 510         


Cys Cys Cys Cys Gly Ala Gly Cys Cys Cys Gly Thr Gly Ala Cys Ala 
        515                 520                 525             


Gly Thr Gly Thr Cys Cys Thr Gly Gly Ala Ala Thr Ala Gly Cys Gly 
    530                 535                 540                 


Gly Cys Gly Cys Cys Cys Thr Gly Ala Cys Cys Thr Cys Cys Gly Gly 
545                 550                 555                 560 


Cys Gly Thr Gly Cys Ala Thr Ala Cys Cys Thr Thr Cys Cys Cys Thr 
                565                 570                 575     


Gly Cys Cys Gly Thr Cys Cys Thr Gly Cys Ala Ala Ala Gly Cys Ala 
            580                 585                 590         


Gly Cys Gly Gly Cys Cys Thr Gly Thr Ala Cys Ala Gly Cys Cys Thr 
        595                 600                 605             


Gly Thr Cys Cys Thr Cys Cys Gly Thr Gly Gly Thr Gly Ala Cys Ala 
    610                 615                 620                 


Gly Thr Cys Cys Cys Thr Thr Cys Cys Thr Cys Cys Ala Gly Cys Cys 
625                 630                 635                 640 


Thr Gly Gly Gly Ala Ala Cys Cys Ala Ala Gly Ala Cys Cys Thr Ala 
                645                 650                 655     


Cys Ala Cys Cys Thr Gly Cys Ala Ala Thr Gly Thr Gly Gly Ala Cys 
            660                 665                 670         


Cys Ala Cys Ala Ala Gly Cys Cys Thr Ala Gly Cys Ala Ala Cys Ala 
        675                 680                 685             


Cys Cys Ala Ala Gly Gly Thr Gly Gly Ala Cys Ala Ala Gly Ala Gly 
    690                 695                 700                 


Gly Gly Thr Cys Gly Ala Gly Cys Cys Cys Ala Ala Gly Thr Cys Cys 
705                 710                 715                 720 


Thr Gly Cys Gly Ala Thr Ala Ala Gly Ala Cys Ala Cys Ala Cys Ala 
                725                 730                 735     


Cys Cys Thr Cys Cys Cys Cys Thr Cys Cys Thr Thr Cys Cys Cys Cys 
            740                 745                 750         


Thr Gly Cys Thr Cys Cys Thr Gly Ala Gly Cys Thr Gly Cys Thr Cys 
        755                 760                 765             


Gly Gly Cys Gly Gly Ala Ala Gly Cys Ala Gly Cys Gly Thr Gly Thr 
    770                 775                 780                 


Thr Cys Cys Thr Gly Thr Thr Cys Cys Cys Thr Cys Cys Thr Ala Ala 
785                 790                 795                 800 


Gly Cys Cys Thr Ala Ala Gly Gly Ala Cys Ala Cys Cys Cys Thr Gly 
                805                 810                 815     


Ala Thr Gly Ala Thr Cys Ala Gly Cys Cys Gly Gly Ala Cys Cys Cys 
            820                 825                 830         


Cys Thr Gly Ala Gly Gly Thr Gly Ala Cys Cys Thr Gly Thr Gly Thr 
        835                 840                 845             


Cys Gly Thr Gly Gly Thr Gly Gly Ala Cys Gly Thr Gly Thr Cys Cys 
    850                 855                 860                 


Cys Ala Cys Gly Ala Ala Gly Ala Cys Cys Cys Cys Gly Ala Gly Gly 
865                 870                 875                 880 


Thr Gly Ala Ala Ala Thr Thr Cys Ala Ala Cys Thr Gly Gly Thr Ala 
                885                 890                 895     


Cys Gly Thr Gly Gly Ala Cys Gly Gly Cys Gly Thr Cys Gly Ala Gly 
            900                 905                 910         


Gly Thr Gly Cys Ala Cys Ala Ala Cys Gly Cys Thr Ala Ala Gly Ala 
        915                 920                 925             


Cys Ala Ala Ala Ala Cys Cys Cys Ala Gly Gly Gly Ala Gly Gly Ala 
    930                 935                 940                 


Gly Cys Ala Gly Thr Ala Cys Ala Ala Thr Thr Cys Cys Ala Cys Cys 
945                 950                 955                 960 


Thr Ala Cys Cys Gly Gly Gly Thr Cys Gly Thr Gly Thr Cys Cys Gly 
                965                 970                 975     


Thr Gly Cys Thr Gly Ala Cys Cys Gly Thr Gly Cys Thr Gly Cys Ala 
            980                 985                 990         


Cys Cys Ala Gly Gly Ala Cys Thr  Gly Gly Cys Thr Gly  Ala Ala Cys 
        995                 1000                 1005             


Gly Gly  Cys Ala Ala Ala Gly  Ala Gly Thr Ala Cys  Ala Ala Gly 
    1010                 1015                 1020             


Thr Gly  Thr Ala Ala Gly Gly  Thr Cys Ala Gly Cys  Ala Ala Thr 
    1025                 1030                 1035             


Ala Ala  Gly Gly Cys Cys Cys  Thr Gly Cys Cys Thr  Gly Cys Cys 
    1040                 1045                 1050             


Cys Cys  Cys Ala Thr Thr Gly  Ala Gly Ala Ala Gly  Ala Cys Cys 
    1055                 1060                 1065             


Ala Thr  Thr Thr Cys Cys Ala  Ala Gly Gly Cys Cys  Ala Ala Gly 
    1070                 1075                 1080             


Gly Gly  Cys Cys Ala Gly Cys  Cys Cys Ala Gly Gly  Gly Ala Ala 
    1085                 1090                 1095             


Cys Cys  Thr Cys Ala Gly Gly  Thr Gly Thr Ala Cys  Ala Cys Cys 
    1100                 1105                 1110             


Cys Thr  Gly Cys Cys Thr Cys  Cys Cys Thr Cys Cys  Cys Gly Gly 
    1115                 1120                 1125             


Gly Ala  Cys Gly Ala Gly Cys  Thr Gly Ala Cys Cys  Ala Ala Gly 
    1130                 1135                 1140             


Ala Ala  Cys Cys Ala Gly Gly  Thr Cys Ala Gly Cys  Cys Thr Gly 
    1145                 1150                 1155             


Ala Cys  Cys Thr Gly Cys Cys  Thr Cys Gly Thr Gly  Ala Ala Gly 
    1160                 1165                 1170             


Gly Gly  Cys Thr Thr Cys Thr  Ala Cys Cys Cys Thr  Ala Gly Cys 
    1175                 1180                 1185             


Gly Ala  Cys Ala Thr Cys Gly  Cys Cys Gly Thr Gly  Gly Ala Gly 
    1190                 1195                 1200             


Thr Gly  Gly Gly Ala Gly Thr  Cys Cys Ala Ala Cys  Gly Gly Cys 
    1205                 1210                 1215             


Cys Ala  Gly Cys Cys Thr Gly  Ala Gly Ala Ala Cys  Ala Ala Thr 
    1220                 1225                 1230             


Thr Ala  Cys Ala Ala Gly Ala  Cys Cys Ala Cys Cys  Cys Cys Cys 
    1235                 1240                 1245             


Cys Cys  Thr Gly Thr Cys Cys  Thr Gly Gly Ala Cys  Thr Cys Cys 
    1250                 1255                 1260             


Gly Ala  Cys Gly Gly Ala Thr  Cys Cys Thr Thr Cys  Thr Thr Cys 
    1265                 1270                 1275             


Cys Thr  Gly Thr Ala Cys Thr  Cys Cys Ala Ala Gly  Cys Thr Gly 
    1280                 1285                 1290             


Ala Cys  Ala Gly Thr Gly Gly  Ala Thr Ala Ala Gly  Thr Cys Cys 
    1295                 1300                 1305             


Cys Gly  Gly Thr Gly Gly Cys  Ala Gly Cys Ala Gly  Gly Gly Ala 
    1310                 1315                 1320             


Ala Ala  Thr Gly Thr Gly Thr  Thr Cys Thr Cys Cys  Thr Gly Cys 
    1325                 1330                 1335             


Thr Cys  Cys Gly Thr Cys Ala  Thr Gly Cys Ala Cys  Gly Ala Ala 
    1340                 1345                 1350             


Gly Cys  Cys Cys Thr Gly Cys  Ala Thr Ala Ala Cys  Cys Ala Cys 
    1355                 1360                 1365             


Thr Ala  Cys Ala Cys Ala Cys  Ala Gly Ala Ala Gly  Ala Gly Cys 
    1370                 1375                 1380             


Cys Thr  Gly Thr Cys Cys Cys  Thr Gly Ala Gly Cys  Cys Cys Thr 
    1385                 1390                 1395             


Gly Gly  Cys Ala Ala Gly Thr  Gly Ala 
    1400                 1405         


<210>  40
<211>  708
<212>  PRT
<213>  artificial sequence

<220>
<223>  0318-IgG1.3f LC; 0318-IgG1.1f LC; 0318-IgG1-Aba LC; 0318-IgG4-Aba
       LC

<400>  40

Ala Thr Gly Ala Gly Gly Gly Cys Thr Thr Gly Gly Ala Thr Cys Thr 
1               5                   10                  15      


Thr Cys Thr Thr Thr Cys Thr Gly Cys Thr Cys Thr Gly Cys Cys Thr 
            20                  25                  30          


Gly Gly Cys Cys Gly Gly Gly Cys Gly Cys Gly Cys Cys Thr Thr Gly 
        35                  40                  45              


Gly Cys Cys Gly Ala Thr Ala Thr Cys Gly Thr Gly Cys Thr Gly Ala 
    50                  55                  60                  


Cys Cys Cys Ala Gly Ala Gly Cys Cys Cys Cys Gly Ala Thr Ala Gly 
65                  70                  75                  80  


Cys Cys Thr Gly Gly Cys Thr Gly Thr Gly Ala Gly Cys Cys Thr Gly 
                85                  90                  95      


Gly Gly Cys Gly Ala Gly Ala Gly Ala Gly Cys Cys Ala Cys Cys Ala 
            100                 105                 110         


Thr Cys Ala Ala Cys Thr Gly Cys Ala Gly Gly Gly Cys Cys Thr Cys 
        115                 120                 125             


Cys Cys Ala Gly Ala Gly Cys Gly Thr Cys Gly Ala Cys Ala Cys Cys 
    130                 135                 140                 


Thr Thr Cys Gly Ala Cys Thr Ala Cys Ala Gly Cys Thr Thr Cys Cys 
145                 150                 155                 160 


Thr Cys Cys Ala Cys Thr Gly Gly Thr Ala Cys Cys Ala Gly Cys Ala 
                165                 170                 175     


Gly Ala Ala Gly Cys Cys Thr Gly Gly Cys Cys Ala Gly Cys Cys Cys 
            180                 185                 190         


Cys Cys Cys Ala Ala Gly Cys Thr Gly Cys Thr Gly Ala Thr Cys Thr 
        195                 200                 205             


Ala Cys Ala Gly Gly Gly Cys Cys Ala Gly Cys Ala Ala Cys Cys Thr 
    210                 215                 220                 


Gly Gly Ala Gly Ala Gly Cys Gly Gly Ala Gly Thr Gly Cys Cys Cys 
225                 230                 235                 240 


Gly Ala Thr Ala Gly Gly Thr Thr Cys Ala Gly Cys Gly Gly Cys Ala 
                245                 250                 255     


Gly Cys Gly Gly Cys Thr Cys Cys Gly Gly Ala Ala Cys Cys Gly Ala 
            260                 265                 270         


Cys Thr Thr Thr Ala Cys Cys Cys Thr Cys Ala Cys Cys Ala Thr Cys 
        275                 280                 285             


Ala Gly Cys Thr Cys Cys Cys Thr Gly Cys Ala Gly Gly Cys Cys Gly 
    290                 295                 300                 


Ala Gly Gly Ala Thr Gly Thr Gly Gly Cys Cys Gly Thr Cys Thr Ala 
305                 310                 315                 320 


Cys Thr Ala Cys Thr Gly Cys Cys Ala Gly Cys Ala Gly Ala Gly Cys 
                325                 330                 335     


Ala Ala Cys Cys Ala Gly Gly Ala Cys Cys Cys Cys Thr Ala Cys Ala 
            340                 345                 350         


Cys Cys Thr Thr Thr Gly Gly Cys Cys Ala Gly Gly Gly Cys Ala Cys 
        355                 360                 365             


Cys Ala Ala Gly Cys Thr Gly Gly Ala Gly Ala Thr Cys Ala Ala Gly 
    370                 375                 380                 


Ala Gly Gly Ala Cys Cys Gly Thr Gly Gly Cys Cys Gly Cys Cys Cys 
385                 390                 395                 400 


Cys Cys Thr Cys Cys Gly Thr Gly Thr Thr Cys Ala Thr Cys Thr Thr 
                405                 410                 415     


Cys Cys Cys Thr Cys Cys Cys Ala Gly Cys Gly Ala Cys Gly Ala Gly 
            420                 425                 430         


Cys Ala Gly Cys Thr Gly Ala Ala Gly Ala Gly Cys Gly Gly Ala Ala 
        435                 440                 445             


Cys Cys Gly Cys Cys Ala Gly Cys Gly Thr Gly Gly Thr Gly Thr Gly 
    450                 455                 460                 


Cys Cys Thr Gly Cys Thr Gly Ala Ala Cys Ala Ala Cys Thr Thr Cys 
465                 470                 475                 480 


Thr Ala Cys Cys Cys Cys Ala Gly Gly Gly Ala Gly Gly Cys Cys Ala 
                485                 490                 495     


Ala Gly Gly Thr Gly Cys Ala Gly Thr Gly Gly Ala Ala Gly Gly Thr 
            500                 505                 510         


Cys Gly Ala Cys Ala Ala Cys Gly Cys Cys Cys Thr Gly Cys Ala Gly 
        515                 520                 525             


Ala Gly Cys Gly Gly Cys Ala Ala Thr Ala Gly Cys Cys Ala Gly Gly 
    530                 535                 540                 


Ala Gly Ala Gly Cys Gly Thr Gly Ala Cys Cys Gly Ala Ala Cys Ala 
545                 550                 555                 560 


Gly Gly Ala Cys Ala Gly Cys Ala Ala Gly Gly Ala Cys Thr Cys Cys 
                565                 570                 575     


Ala Cys Cys Thr Ala Cys Thr Cys Cys Cys Thr Gly Ala Gly Cys Ala 
            580                 585                 590         


Gly Cys Ala Cys Cys Cys Thr Gly Ala Cys Cys Cys Thr Gly Ala Gly 
        595                 600                 605             


Cys Ala Ala Gly Gly Cys Cys Gly Ala Cys Thr Ala Cys Gly Ala Gly 
    610                 615                 620                 


Ala Ala Gly Cys Ala Cys Ala Ala Gly Gly Thr Gly Thr Ala Cys Gly 
625                 630                 635                 640 


Cys Cys Thr Gly Thr Gly Ala Gly Gly Thr Gly Ala Cys Cys Cys Ala 
                645                 650                 655     


Cys Cys Ala Gly Gly Gly Ala Cys Thr Gly Ala Gly Cys Ala Gly Cys 
            660                 665                 670         


Cys Cys Cys Gly Thr Gly Ala Cys Ala Ala Ala Gly Ala Gly Cys Thr 
        675                 680                 685             


Thr Thr Ala Ala Cys Ala Gly Gly Gly Gly Cys Gly Ala Gly Thr Gly 
    690                 695                 700                 


Cys Thr Gly Ala 
705             


<210>  41
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  0318 AB - VH CDR3 (mutant #1)

<400>  41

Asp Gln Gly Ile Arg Arg Gln Phe Ala Tyr 
1               5                   10  


<210>  42
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  0318 AB - VH CDR3 (mutant #2)

<400>  42

Asp Leu Gly Ile Arg Arg Gln Phe Ala Tyr 
1               5                   10  


<210>  43
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  0318 Ab - VH CDR1 (mutant #3)

<400>  43

Thr Tyr Ala Gln His 
1               5   


<210>  44
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  0318 Ab - VH CDR1 (mutant #4)

<400>  44

Thr Tyr Ala Leu His 
1               5   


<210>  45
<211>  451
<212>  PRT
<213>  artificial sequence

<220>
<223>  0318 Ab - HC (IgG4)

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Thr Lys Ser Ser Asn Tyr Ala Thr Tyr Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Met Gly Ile Arg Arg Gln Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val 
        435                 440                 445             


Ser Leu Gly 
    450     


<210>  46
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  WT IgG1 Constant Region (Allotypic Variant)

<400>  46

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  47
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG1.1f HC Constant Region

<400>  47

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  48
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG1.3f HC Constant Region

<400>  48

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  49
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Linker

<400>  49

Pro Val Gly Val Val 
1               5   


<210>  50
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  Amino Acid Residues 27-37 of Human TREM-1, Isoform 1

<400>  50

Glu Lys Tyr Glu Leu Lys Glu Gly Gln Thr Leu 
1               5                   10      


<210>  51
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  Amino Acid Residues 88-100 of Human TREM-1, Isoform 1

<400>  51

Glu Asp Tyr His Asp His Gly Leu Leu Arg Val Arg Met 
1               5                   10              


<210>  52
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Amino Acid Residues 120-128 of Human TREM-1, Isoform 1

<400>  52

Lys Glu Pro His Met Leu Phe Asp Arg 
1               5                   


<210>  53
<211>  124
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047248 VH

<400>  53

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Tyr Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Thr His Tyr Ser Gly Ile Ser Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Tyr Asp Ile Leu Thr Gly Tyr Glu Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  54
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047248 VL

<400>  54

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  55
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047246, P1-047247 VH

<400>  55

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Asn Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Asp Ser Gly Tyr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Leu Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Val Leu Trp Phe Gly Glu Leu Leu Pro Leu Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  56
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047246, P1-047239 VL

<400>  56

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  57
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047247 VL

<400>  57

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Glu Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  58
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047334 VH

<400>  58

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Ser 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Gly Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Met Val Arg Gly Asn Tyr Phe Tyr Phe Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  59
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047334 VL

<400>  59

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  60
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047239 VH

<400>  60

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Glu Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Ser Ala Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Arg His Tyr Tyr Gly Ser Thr Ser Tyr Phe Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  61
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047248 HCDR1

<400>  61

Ser Ser Tyr Trp Ser 
1               5   


<210>  62
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047248 HCDR2

<400>  62

Tyr Thr His Tyr Ser Gly Ile Ser Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  63
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047248 HCDR3

<400>  63

Glu Gly Tyr Asp Ile Leu Thr Gly Tyr Glu Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  64
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047248, P1-047247 LCDR1

<400>  64

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  65
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047248, P1-047247, P1-047317 LCDR2

<400>  65

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  66
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047248 LCDR3

<400>  66

Gln Gln Tyr Gly Ser Ser Pro Thr 
1               5               


<210>  67
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047246, P1-047247 HCDR1

<400>  67

Asn Tyr Tyr Trp Thr 
1               5   


<210>  68
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047246, P1-047247 HCDR2

<400>  68

Tyr Ile Tyr Asp Ser Gly Tyr Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  69
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047246, P1-047247 HCDR3

<400>  69

Gly Val Leu Trp Phe Gly Glu Leu Leu Pro Leu Leu Asp Tyr 
1               5                   10                  


<210>  70
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047246, P1-047334, P1-047239, P1-047323, P1-047328 LCDR1

<400>  70

Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  71
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047246, P1-047239, P1-047323, P1-047328 LCDR2

<400>  71

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  72
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047246, P1-047239 LCDR3

<400>  72

Gln Gln Phe Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  73
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047247, P1-047317 LCDR3

<400>  73

Gln Gln Tyr Gly Ser Ser Pro Leu Thr 
1               5                   


<210>  74
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047334, P1-047292, P1-047289, P1-047306 HCDR1

<400>  74

Ser Ser Ala Ile Ser 
1               5   


<210>  75
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047334 HCDR2

<400>  75

Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Gly Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  76
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047334 HCDR3

<400>  76

Met Val Arg Gly Asn Tyr Phe Tyr Phe Tyr Gly Met Asp Val 
1               5                   10                  


<210>  77
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  LCDR2

<400>  77

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  78
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  LCDR3

<400>  78

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  79
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047239 HCDR1

<400>  79

Asn Tyr Gly Met His 
1               5   


<210>  80
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047239 HCDR2

<400>  80

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  81
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047239 HCDR3

<400>  81

Asp Gly Arg His Tyr Tyr Gly Ser Thr Ser Tyr Phe Gly Met Asp Val 
1               5                   10                  15      


<210>  82
<211>  126
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047305 VH

<400>  82

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Gly Thr Phe Ser Ser Ser 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Thr Pro Ile Phe Gly Thr Ala Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Ala Ser Thr Ser Thr Gly Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Phe Thr Pro Arg Tyr Arg Gly Ser Ser His His Tyr Tyr Tyr Ala 
            100                 105                 110         


Leu Gly Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  83
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047305, P1-047314, P1-047290, P1-047308, P1-047292, P1-047322,
       P1-047301, P1-047265 VL

<400>  83

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  84
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047309 VH

<400>  84

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Asn Pro Ser Gly Gly Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Pro Gly Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ala Val Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  85
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047309 VL

<400>  85

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  86
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047313 VH

<400>  86

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Arg Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  87
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047313 VL

<400>  87

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  88
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047307, P1-047320, P1-047314, P1-047312, P1-047317 VH

<400>  88

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Gln Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  89
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047307, P1-047302, P1-047306 VL

<400>  89

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  90
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047312, P1-047318 VL

<400>  90

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  91
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047318 VH

<400>  91

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Gln Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  92
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047320, P1-047319 VL

<400>  92

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  93
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047311 VH

<400>  93

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Gln Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  94
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047311 VL

<400>  94

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  95
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047294 VH

<400>  95

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg His 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Glu Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ala Ala Asp Glu Pro Thr Ser Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Tyr Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  96
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047294 VL

<400>  96

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  97
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047290, P1-047291, P1-047296, P1-047297, P1-047300, P1-047302 
       VH

<400>  97

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg His 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ala Ala Asp Glu Pro Thr Ser Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Tyr Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  98
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047291 VL

<400>  98

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  99
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047296 VL

<400>  99

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  100
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047297 VL

<400>  100

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  101
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047300 VL

<400>  101

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


His Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  102
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047308, P1-047319 VH

<400>  102

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  103
<211>  126
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047292 VH

<400>  103

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Ser 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Ser Thr Gly Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Arg Val Arg Gly Val Ser His Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  104
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047322 VH

<400>  104

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ser Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Phe Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Arg Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser His Phe Ser Gly Ser Gly Ser Ser His Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Met His Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  105
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047310 VH

<400>  105

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ser Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Lys Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asn Ser Trp Thr Thr Ser Leu Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  106
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047310 VL

<400>  106

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  107
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047299 VH

<400>  107

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg Tyr 
            20                  25                  30          


Ala Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Ile Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser His Phe Tyr Gly Ser Gly Ser Ser His Phe Tyr Tyr Tyr 
            100                 105                 110         


Gly Met His Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  108
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047299 VL

<400>  108

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  109
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047301 VH

<400>  109

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg Tyr 
            20                  25                  30          


Ala Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Ile Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser His Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  110
<211>  126
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047289 VH

<400>  110

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Ser 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asp Ser Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Phe Thr Pro Arg Tyr Arg Gly Ser Ser His His Tyr Phe Tyr Ala 
            100                 105                 110         


Leu Gly Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  111
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047289 VL

<400>  111

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  112
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047306 VH

<400>  112

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Ser 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ser Gln Ser Arg Ser Ser Asn Tyr Tyr Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  113
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047305 HCDR1

<400>  113

Ser Ser Ala Val Ser 
1               5   


<210>  114
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047305 HCDR2

<400>  114

Gly Ile Thr Pro Ile Phe Gly Thr Ala Asp Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  115
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047305 HCDR3

<400>  115

Thr Pro Arg Tyr Arg Gly Ser Ser His His Tyr Tyr Tyr Ala Leu Gly 
1               5                   10                  15      


Val 
    


<210>  116
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  LCDR1

<400>  116

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  117
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  LCDR3

<400>  117

Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  118
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047309 HCDR1

<400>  118

Thr Tyr Ala Ile Ser 
1               5   


<210>  119
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047309 HCDR2

<400>  119

Gly Ile Asn Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  120
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047309 HCDR3

<400>  120

Gly Gly Ala Val Gly Phe Ala Tyr 
1               5               


<210>  121
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047309 LCDR3

<400>  121

Gln Gln Ala Asn Ser Phe Pro Phe Thr 
1               5                   


<210>  122
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047317 HCDR1

<400>  122

Ile Tyr Val Ile Ser 
1               5   


<210>  123
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047313 HCDR2

<400>  123

Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Arg Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  124
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047317 HCDR3

<400>  124

Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu Asp Val 
1               5                   10                  15      


<210>  125
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047299 LCDR3

<400>  125

Gln Gln Tyr Asn Ser Tyr Pro Trp Thr 
1               5                   


<210>  126
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047317 HCDR2

<400>  126

Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Gln Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  127
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047311 HCDR2

<400>  127

Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Gln Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  128
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047294, P1-047290, P1-047291, P1-047296, P1-047297, P1-047300,
       P1-047302 HCDR1

<400>  128

Arg His Ala Ile Ser 
1               5   


<210>  129
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047294 HCDR2

<400>  129

Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Glu Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  130
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047294 HCDR3

<400>  130

Ser Tyr Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Val 
        


<210>  131
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047319 HCDR2

<400>  131

Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  132
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047302 HCDR3

<400>  132

Ser Tyr Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Val 
        


<210>  133
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047328 LCDR3

<400>  133

Gln Gln Tyr Asn Ser Tyr Pro Ile Thr 
1               5                   


<210>  134
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047292 HCDR2

<400>  134

Gly Ile Ile Pro Ile Phe Ser Thr Gly Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  135
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047292 HCDR3

<400>  135

Ser Thr Arg Val Arg Gly Val Ser His Tyr Tyr Tyr Tyr Gly Leu Asp 
1               5                   10                  15      


Val 
    


<210>  136
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047322 HCDR1

<400>  136

Ser Tyr Ala Phe Thr 
1               5   


<210>  137
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047322 HCDR2

<400>  137

Gly Ile Ile Pro Ile Phe Arg Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  138
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047322 HCDR3

<400>  138

Ser His Phe Ser Gly Ser Gly Ser Ser His Tyr Tyr Tyr Tyr Gly Met 
1               5                   10                  15      


His Val 
        


<210>  139
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047310 HCDR1

<400>  139

Arg Tyr Ala Ile Ser 
1               5   


<210>  140
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047310 HCDR2

<400>  140

Gly Ile Ile Pro Ile Phe Gly Thr Ser Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  141
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047310 HCDR3

<400>  141

Gly Gly Asn Ser Trp Thr Thr Ser Leu Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  142
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047299, P1-047301 HCDR1

<400>  142

Arg Tyr Ala Phe Ser 
1               5   


<210>  143
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047299, P1-047301 HCDR2

<400>  143

Gly Ile Ile Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  144
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047299 HCDR3

<400>  144

Ser His Phe Tyr Gly Ser Gly Ser Ser His Phe Tyr Tyr Tyr Gly Met 
1               5                   10                  15      


His Val 
        


<210>  145
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047301 HCDR3

<400>  145

Ser His Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr Gly Leu 
1               5                   10                  15      


Asp Val 
        


<210>  146
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047289 HCDR2

<400>  146

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asp Ser Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  147
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047289 HCDR3

<400>  147

Thr Pro Arg Tyr Arg Gly Ser Ser His His Tyr Phe Tyr Ala Leu Gly 
1               5                   10                  15      


Val 
    


<210>  148
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047289 LCDR3

<400>  148

Gln Gln Phe Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  149
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047306 HCDR2

<400>  149

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  150
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047306 HCDR3

<400>  150

Ala Ser Gln Ser Arg Ser Ser Asn Tyr Tyr Tyr Tyr Gly Leu Asp Val 
1               5                   10                  15      


<210>  151
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  LSPGK (C-terminal end of heavy chain)

<400>  151

Leu Ser Pro Gly Lys 
1               5   


<210>  152
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  LSPG (C-terminal end of heavy chain)

<400>  152

Leu Ser Pro Gly 
1               


<210>  153
<211>  126
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047323, P1-047328 VH

<400>  153

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ile Asn Ser 
            20                  25                  30          


Glu Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Gly Ile Ile Pro Ile Phe Asp Ile Thr Asn Tyr Ala Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Met Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Lys Thr Tyr Tyr Asp Ile Leu Thr Tyr His Tyr His Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  154
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047323 VL

<400>  154

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  155
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047328 VL

<400>  155

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  156
<211>  126
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047263, P1-047265 VH

<400>  156

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Pro Thr Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Val Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asp Gly Leu Asn Met Val Arg Gly Val His Asn Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  157
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047263 VL

<400>  157

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  158
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047317 VL

<400>  158

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  159
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047323, P1-047328 HCDR1

<400>  159

Asn Ser Glu Ala Ile Asn 
1               5       


<210>  160
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047323, P1-047328 HCDR2

<400>  160

Gly Ile Ile Pro Ile Phe Asp Ile Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  161
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047323, P1-047328 HCDR3

<400>  161

Thr Tyr Tyr Asp Ile Leu Thr Tyr His Tyr His Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  162
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047323 LCDR3

<400>  162

Gln Gln Phe Asn Ser Tyr Pro Ile Thr 
1               5                   


<210>  163
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047263, P1-047265 HCDR1

<400>  163

Thr Tyr Asp Ile Asn 
1               5   


<210>  164
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047263, P1-047265 HCDR2

<400>  164

Trp Val Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  165
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047263, P1-047265 HCDR3

<400>  165

Asp Gly Leu Asn Met Val Arg Gly Val His Asn Tyr Tyr Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  166
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047263 LCDR3

<400>  166

Gln Gln Tyr Asn Ser Tyr Pro Pro Thr 
1               5                   


<210>  167
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047317 LCDR1

<400>  167

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  168
<211>  454
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047239 HC

<400>  168

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Glu Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Ser Ala Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Arg His Tyr Tyr Gly Ser Thr Ser Tyr Phe Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly 
    450                 


<210>  169
<211>  451
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047246 HC

<400>  169

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Asn Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Asp Ser Gly Tyr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Leu Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Val Leu Trp Phe Gly Glu Leu Leu Pro Leu Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
225                 230                 235                 240 


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  170
<211>  451
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047247 HC

<400>  170

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Asn Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Asp Ser Gly Tyr Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Leu Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Val Leu Trp Phe Gly Glu Leu Leu Pro Leu Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
225                 230                 235                 240 


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  171
<211>  453
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047248 HC

<400>  171

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Tyr Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Thr His Tyr Ser Gly Ile Ser Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Tyr Asp Ile Leu Thr Gly Tyr Glu Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly 
    450             


<210>  172
<211>  455
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047323 HC

<400>  172

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ile Asn Ser 
            20                  25                  30          


Glu Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Gly Ile Ile Pro Ile Phe Asp Ile Thr Asn Tyr Ala Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Met Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Lys Thr Tyr Tyr Asp Ile Leu Thr Tyr His Tyr His Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly 
    450                 455 


<210>  173
<211>  455
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047328 HC

<400>  173

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ile Asn Ser 
            20                  25                  30          


Glu Ala Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Gly Ile Ile Pro Ile Phe Asp Ile Thr Asn Tyr Ala Gln Lys 
    50                  55                  60                  


Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Met Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Lys Thr Tyr Tyr Asp Ile Leu Thr Tyr His Tyr His Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly 
    450                 455 


<210>  174
<211>  452
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047334 HC

<400>  174

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Ser 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Thr Asn Gly Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Met Val Arg Gly Asn Tyr Phe Tyr Phe Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
225                 230                 235                 240 


Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly 
    450         


<210>  175
<211>  455
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047263 HC

<400>  175

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Pro Thr Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Val Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asp Gly Leu Asn Met Val Arg Gly Val His Asn Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly 
    450                 455 


<210>  176
<211>  455
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047265 HC

<400>  176

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Pro Thr Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Val Asn Pro Asn Ser Gly Asn Thr Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Thr Arg Asn Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asp Gly Leu Asn Met Val Arg Gly Val His Asn Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly 
    450                 455 


<210>  177
<211>  455
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047289 HC

<400>  177

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Ser 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asp Ser Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Phe Thr Pro Arg Tyr Arg Gly Ser Ser His His Tyr Phe Tyr Ala 
            100                 105                 110         


Leu Gly Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly 
    450                 455 


<210>  178
<211>  456
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047290 HC

<400>  178

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg His 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ala Ala Asp Glu Pro Thr Ser Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Tyr Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  179
<211>  456
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047291 HC

<400>  179

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg His 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ala Ala Asp Glu Pro Thr Ser Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Tyr Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  180
<211>  455
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047292 HC

<400>  180

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Ser 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Ser Thr Gly Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Arg Val Arg Gly Val Ser His Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly 
    450                 455 


<210>  181
<211>  456
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047294 HC

<400>  181

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg His 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Glu Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ala Ala Asp Glu Pro Thr Ser Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Tyr Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  182
<211>  456
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047296 HC

<400>  182

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg His 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ala Ala Asp Glu Pro Thr Ser Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Tyr Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  183
<211>  456
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047297 HC

<400>  183

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg His 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ala Ala Asp Glu Pro Thr Ser Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Tyr Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  184
<211>  456
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047299 HC

<400>  184

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg Tyr 
            20                  25                  30          


Ala Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Ile Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser His Phe Tyr Gly Ser Gly Ser Ser His Phe Tyr Tyr Tyr 
            100                 105                 110         


Gly Met His Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  185
<211>  456
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047300 HC

<400>  185

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg His 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ala Ala Asp Glu Pro Thr Ser Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Tyr Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  186
<211>  456
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047301 HC

<400>  186

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg Tyr 
            20                  25                  30          


Ala Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Ile Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser His Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  187
<211>  456
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047302 HC

<400>  187

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Arg His 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ala Ala Asp Glu Pro Thr Ser Thr Thr Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Tyr Phe Tyr Gly Ser Gly Ser Ser Asn Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Leu Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  188
<211>  455
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047305 HC

<400>  188

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Gly Thr Phe Ser Ser Ser 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Thr Pro Ile Phe Gly Thr Ala Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Ala Ser Thr Ser Thr Gly Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Phe Thr Pro Arg Tyr Arg Gly Ser Ser His His Tyr Tyr Tyr Ala 
            100                 105                 110         


Leu Gly Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly 
    450                 455 


<210>  189
<211>  454
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047306 HC

<400>  189

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Ser 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ser Gln Ser Arg Ser Ser Asn Tyr Tyr Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly 
    450                 


<210>  190
<211>  454
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047307 HC

<400>  190

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Gln Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly 
    450                 


<210>  191
<211>  454
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047308 HC

<400>  191

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly 
    450                 


<210>  192
<211>  446
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047309 HC

<400>  192

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Asn Pro Ser Gly Gly Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Pro Gly Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ala Val Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  193
<211>  454
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047310 HC

<400>  193

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ser Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Lys Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asn Ser Trp Thr Thr Ser Leu Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly 
    450                 


<210>  194
<211>  454
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047311 HC

<400>  194

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Gln Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly 
    450                 


<210>  195
<211>  454
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047312 HC

<400>  195

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Gln Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly 
    450                 


<210>  196
<211>  454
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047313 HC

<400>  196

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Arg Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly 
    450                 


<210>  197
<211>  454
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047314 HC

<400>  197

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Gln Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly 
    450                 


<210>  198
<211>  454
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047317 HC

<400>  198

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Gln Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly 
    450                 


<210>  199
<211>  454
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047318 HC

<400>  199

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Gln Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly 
    450                 


<210>  200
<211>  454
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047319 HC

<400>  200

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly 
    450                 


<210>  201
<211>  454
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047320 HC

<400>  201

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Leu Phe Gly Thr Pro Asn Tyr Ala Gln Gln Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Gly Pro Gly Ser Ser His Tyr Ser Tyr Tyr Gly Leu 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly 
    450                 


<210>  202
<211>  456
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047322 HC

<400>  202

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ser Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Phe Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Arg Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser His Phe Ser Gly Ser Gly Ser Ser His Tyr Tyr Tyr Tyr 
            100                 105                 110         


Gly Met His Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  203
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047239, P1-047246 LC

<400>  203

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  204
<211>  215
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047247 LC

<400>  204

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Glu Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  205
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047248 LC

<400>  205

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  206
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047323 LC

<400>  206

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  207
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047328 LC

<400>  207

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  208
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047334 LC

<400>  208

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  209
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047263 LC

<400>  209

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  210
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047265, P1-047290, P1-047292, P1-047301, P1-047302, P1-047305,
       P1-047306, P1-047308, P1-047314, P1-047322  LC

<400>  210

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  211
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047289 LC

<400>  211

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  212
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047291 LC

<400>  212

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  213
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047294 LC

<400>  213

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  214
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047296 LC

<400>  214

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  215
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047297 LC

<400>  215

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  216
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047299 LC

<400>  216

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  217
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047300 LC

<400>  217

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


His Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  218
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047307 LC

<400>  218

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  219
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047309 LC

<400>  219

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  220
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047310 LC

<400>  220

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  221
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047311 LC

<400>  221

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  222
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047312, P1-047318 LC

<400>  222

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  223
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047313 LC

<400>  223

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  224
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047317 LC

<400>  224

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  225
<211>  214
<212>  PRT
<213>  artificial sequence

<220>
<223>  P1-047319, P1-047320 LC

<400>  225

Asp Ile Gln Met Thr Gln Ser Pro Thr Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  226
<211>  1362
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047239 HC

<400>  226
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag ctactgaatt caccttcagt aactatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg cttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaattga acagcctgag cgccgaggac tcggctgtgt attactgtgc gagagatggg      300

aggcattact atggttcgac ctcctacttc ggcatggacg tctggggcca agggaccacg      360

gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660

aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720

gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362


<210>  227
<211>  1353
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047246 HC

<400>  227
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcact aattactact ggacctggat ccggcagccc      120

ccagggaagg gactggagtg gattgggtat atctatgaca gtgggtacac caactacaac      180

ccctccctca agagtcgagt caccttatca atagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgaccgc tgcggacacg gccgtttatt actgtgcgag aggggttcta      300

tggttcgggg agttattacc tctccttgac tactggggcc agggaaccct ggtcaccgtc      360

tcctcagcgt cgaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      420

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      600

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagagagtt      660

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgaa      720

ggggccccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      960

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc caagcagcat cgagaaaacc     1020

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1080

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1200

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacgcaga agagcctctc cctgtccccg ggt                                  1353


<210>  228
<211>  1353
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047247 HC

<400>  228
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcact aattactact ggacctggat ccggcagccc      120

ccagggaagg gactggagtg gattgggtat atctatgaca gtgggtacac caactacaac      180

ccctccctca agagtcgagt caccttatca atagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgaccgc tgcggacacg gccgtttatt actgtgcgag aggggttcta      300

tggttcgggg agttattacc tctccttgac tactggggcc agggaaccct ggtcaccgtc      360

tcctcagcgt cgaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      420

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      600

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagagagtt      660

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgaa      720

ggggccccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      960

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc caagcagcat cgagaaaacc     1020

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1080

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1200

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacgcaga agagcctctc cctgtccccg ggt                                  1353


<210>  229
<211>  1359
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047248 HC

<400>  229
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tgtctggtgg ctccatcagt agttcctact ggagctgggt ccggcagccc      120

ccagggaagg gactggagtg gattggatat acccattaca gtgggatcag caactacaac      180

ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agaagggtac      300

gatattttga ctggttatga gtactacggt atggacgtct ggggccaagg gaccacggtc      360

accgtctcct cagcgtcgac caagggccca tcggtcttcc ccctggcacc ctcctccaag      420

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      480

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      540

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      600

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      660

agagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      720

gccgaagggg ccccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      780

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      840

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      900

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      960

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccaag cagcatcgag     1020

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1080

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1140

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1200

acgcctcccg tgctggactc cgacggctcc ttcttcctct atagcaagct caccgtggac     1260

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1320

aaccactaca cgcagaagag cctctccctg tccccgggt                            1359


<210>  230
<211>  1365
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047323 HC

<400>  230
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcatc aatagcgaag ctatcaactg ggtgcgacag      120

gcccctggac aagggcttga gtggatggga gggatcatcc ctatctttga cattacaaac      180

tacgcacaga agttccaggg cagagtcacg attaccgcgg acgaatccat gagcacagcc      240

tacatggagc tgagcagcct gagatctgag gacacggccg tgtattactg tgcgaagacg      300

tattacgata ttttgactta tcactatcac tacggtatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctcagc gtcgaccaag ggcccatcgg tcttccccct ggcaccctcc      420

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      480

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      660

gacaagagag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      720

cctgaagccg aaggggcccc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      780

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      840

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      900

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      960

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccaagcagc     1020

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1080

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1140

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1200

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc     1260

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1320

ctgcacaacc actacacgca gaagagcctc tccctgtccc cgggt                     1365


<210>  231
<211>  1365
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047328 HC

<400>  231
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcatc aatagcgaag ctatcaactg ggtgcgacag      120

gcccctggac aagggcttga gtggatggga gggatcatcc ctatctttga cattacaaac      180

tacgcacaga agttccaggg cagagtcacg attaccgcgg acgaatccat gagcacagcc      240

tacatggagc tgagcagcct gagatctgag gacacggccg tgtattactg tgcgaagacg      300

tattacgata ttttgactta tcactatcac tacggtatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctcagc gtcgaccaag ggcccatcgg tcttccccct ggcaccctcc      420

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      480

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      660

gacaagagag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      720

cctgaagccg aaggggcccc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      780

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      840

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      900

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      960

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccaagcagc     1020

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1080

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1140

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1200

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc     1260

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1320

ctgcacaacc actacacgca gaagagcctc tccctgtccc cgggt                     1365


<210>  232
<211>  1356
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047334 HC

<400>  232
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc tgtgaaggtc       60

tcctgcaagg cttctggagg caccttcagt agttccgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac aacaaacggc      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc ggctatggtt      300

cggggaaatt acttctactt ctacggtatg gacgtctggg gccaagggac cacggtcacc      360

gtctcctcag cgtcgaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc      420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaga      660

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaagcc      720

gaaggggccc cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      780

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      840

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      960

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccaagcag catcgagaaa     1020

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1080

cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200

cctcccgtgc tggactccga cggctccttc ttcctctata gcaagctcac cgtggacaag     1260

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320

cactacacgc agaagagcct ctccctgtcc ccgggt                               1356


<210>  233
<211>  1365
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047263 HC

<400>  233
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcccc acttatgata tcaactgggt gcgacaggcc      120

actggacaag ggcttgagtg gatgggatgg gtgaacccta acagtggtaa cacaggctat      180

gcacagaagt tccaggacag agtcaccatg accaggaaca cctccataag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagtgacggc      300

cttaatatgg ttcggggagt tcacaactac tacggtatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctcagc gtcgaccaag ggcccatcgg tcttccccct ggcaccctcc      420

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      480

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      660

gacaagagag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      720

cctgaagccg aaggggcccc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      780

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      840

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      900

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      960

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccaagcagc     1020

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1080

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1140

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1200

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc     1260

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1320

ctgcacaacc actacacgca gaagagcctc tccctgtccc cgggt                     1365


<210>  234
<211>  1365
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047265 HC

<400>  234
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcccc acttatgata tcaactgggt gcgacaggcc      120

actggacaag ggcttgagtg gatgggatgg gtgaacccta acagtggtaa cacaggctat      180

gcacagaagt tccaggacag agtcaccatg accaggaaca cctccataag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagtgacggc      300

cttaatatgg ttcggggagt tcacaactac tacggtatgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctcagc gtcgaccaag ggcccatcgg tcttccccct ggcaccctcc      420

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      480

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      660

gacaagagag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      720

cctgaagccg aaggggcccc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      780

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      840

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      900

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      960

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccaagcagc     1020

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1080

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1140

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1200

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc     1260

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1320

ctgcacaacc actacacgca gaagagcctc tccctgtccc cgggt                     1365


<210>  235
<211>  1365
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047289 HC

<400>  235
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctctgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggagga atcatcccta tcttcggtac agcagactcc      180

gcacagaagt tccagggcag agtcacgatt accgcggacg agtccacgag cacagcctac      240

atggaattga acagcctgag atctgaggac acggccgttt actactgtgc gttcacaccc      300

cggtatcgtg ggagctccca ccactacttc tacgctttgg gcgtctgggg ccaagggacc      360

acggtcaccg tctcctcagc gtcgaccaag ggcccatcgg tcttccccct ggcaccctcc      420

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      480

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      660

gacaagagag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      720

cctgaagccg aaggggcccc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      780

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      840

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      900

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      960

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccaagcagc     1020

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1080

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1140

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1200

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc     1260

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1320

ctgcacaacc actacacgca gaagagcctc tccctgtccc cgggt                     1365


<210>  236
<211>  1368
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047290 HC

<400>  236
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcaac agacatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180

gcgcagaagt tccagggcag agtcacgatt gccgcggacg aacccacgag cacaacctac      240

atggagctgc gcagcctgag atctgaggac acggccgtgt attactgtgc gagttcgtat      300

ttctatggtt cggggagttc caactactac tactacggtt tggacgtctg gggccaaggg      360

accacggtca ccgtctcctc agcgtcgacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaag ccgaaggggc cccgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccaagc     1020

agcatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggt                  1368


<210>  237
<211>  1368
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047291 HC

<400>  237
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcaac agacatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180

gcgcagaagt tccagggcag agtcacgatt gccgcggacg aacccacgag cacaacctac      240

atggagctgc gcagcctgag atctgaggac acggccgtgt attactgtgc gagttcgtat      300

ttctatggtt cggggagttc caactactac tactacggtt tggacgtctg gggccaaggg      360

accacggtca ccgtctcctc agcgtcgacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaag ccgaaggggc cccgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccaagc     1020

agcatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggt                  1368


<210>  238
<211>  1365
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047292 HC

<400>  238
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctctgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttagtac aggaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgaa cacagcctac      240

atggatctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagatccact      300

agggttcggg gagtttccca ctactactac tacggtttgg acgtctgggg ccaagggacc      360

acggtcaccg tctcctcagc gtcgaccaag ggcccatcgg tcttccccct ggcaccctcc      420

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      480

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      660

gacaagagag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      720

cctgaagccg aaggggcccc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      780

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      840

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      900

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      960

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccaagcagc     1020

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1080

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1140

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1200

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc     1260

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1320

ctgcacaacc actacacgca gaagagcctc tccctgtccc cgggt                     1365


<210>  239
<211>  1368
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047294 HC

<400>  239
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcaac agacatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180

gcgcaggagt tccagggcag agtcacgatt gccgcggacg aacccacgag cacaacctac      240

atggagctgc gcagcctgag atctgaggac acggccgtgt attactgtgc gagttcgtat      300

ttctatggtt cggggagttc caactactac tactacggtt tggacgtctg gggccaaggg      360

accacggtca ccgtctcctc agcgtcgacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaag ccgaaggggc cccgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccaagc     1020

agcatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggt                  1368


<210>  240
<211>  1368
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047296 HC

<400>  240
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcaac agacatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180

gcgcagaagt tccagggcag agtcacgatt gccgcggacg aacccacgag cacaacctac      240

atggagctgc gcagcctgag atctgaggac acggccgtgt attactgtgc gagttcgtat      300

ttctatggtt cggggagttc caactactac tactacggtt tggacgtctg gggccaaggg      360

accacggtca ccgtctcctc agcgtcgacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaag ccgaaggggc cccgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccaagc     1020

agcatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggt                  1368


<210>  241
<211>  1368
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047297 HC

<400>  241
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcaac agacatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180

gcgcagaagt tccagggcag agtcacgatt gccgcggacg aacccacgag cacaacctac      240

atggagctgc gcagcctgag atctgaggac acggccgtgt attactgtgc gagttcgtat      300

ttctatggtt cggggagttc caactactac tactacggtt tggacgtctg gggccaaggg      360

accacggtca ccgtctcctc agcgtcgacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaag ccgaaggggc cccgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccaagc     1020

agcatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggt                  1368


<210>  242
<211>  1368
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047299 HC

<400>  242
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcaac agatatgctt tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac acccaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacggcctac      240

atggagctga gcagcctgat atctgaggac acggccgtgt attactgtgc gagcagccat      300

ttctatggtt cggggagttc ccacttttac tactacggta tgcacgtctg gggccaaggg      360

accacggtca ccgtctcctc agcgtcgacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaag ccgaaggggc cccgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccaagc     1020

agcatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggt                  1368


<210>  243
<211>  1368
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047300 HC

<400>  243
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcaac agacatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180

gcgcagaagt tccagggcag agtcacgatt gccgcggacg aacccacgag cacaacctac      240

atggagctgc gcagcctgag atctgaggac acggccgtgt attactgtgc aagttcgtat      300

ttctatggtt cggggagttc caactactac tactacggtt tggacgtctg gggccaaggg      360

accacggtca ccgtctcctc agcgtcgacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaag ccgaaggggc cccgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccaagc     1020

agcatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggt                  1368


<210>  244
<211>  1368
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047301 HC

<400>  244
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcaac agatatgctt tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac acccaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacggcctac      240

atggagctga gcagcctgat atctgaggac acggccgtgt attactgtgc gagcagccat      300

ttctatggtt cggggagttc caactactac tactacggtt tggacgtctg gggccaaggg      360

accacggtca ccgtctcctc agcgtcgacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaag ccgaaggggc cccgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccaagc     1020

agcatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggt                  1368


<210>  245
<211>  1368
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047302 HC

<400>  245
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcaac agacatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180

gcgcagaagt tccagggcag agtcacgatt gccgcggacg aacccacgag cacaacctac      240

atggagctgc gcagcctgag atctgaggac acggccgtgt attactgtgc gagttcgtat      300

ttctatggtt cggggagttc caactattac tactacggtt tggacgtctg gggccaaggg      360

accacggtca ccgtctcctc agcgtcgacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaag ccgaaggggc cccgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccaagc     1020

agcatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggt                  1368


<210>  246
<211>  1365
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047305 HC

<400>  246
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaaga cttctggagg caccttcagc agctctgctg tcagctgggt gcgacaggcc      120

cctggacaag ggcttgaatg gatgggagga atcaccccta tttttggtac agcagactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg catccacgag cacaggttat      240

atggaactga gcagcctgag atctgaggac acggccgttt actactgtgc gttcacaccc      300

cgatatcgtg ggagctccca ccactactac tacgctttgg gcgtctgggg ccaagggacc      360

acggtcaccg tctcctcagc gtcgaccaag ggcccatcgg tcttccccct ggcaccctcc      420

tccaagagca cctctggggg cacagcggcc ctgggctgcc tggtcaagga ctacttcccc      480

gaaccggtga cggtgtcgtg gaactcaggc gccctgacca gcggcgtgca caccttcccg      540

gctgtcctac agtcctcagg actctactcc ctcagcagcg tggtgaccgt gccctccagc      600

agcttgggca cccagaccta catctgcaac gtgaatcaca agcccagcaa caccaaggtg      660

gacaagagag ttgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      720

cctgaagccg aaggggcccc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      780

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      840

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      900

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      960

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccaagcagc     1020

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1080

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1140

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1200

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc     1260

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1320

ctgcacaacc actacacgca gaagagcctc tccctgtccc cgggt                     1365


<210>  247
<211>  1362
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047306 HC

<400>  247
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agctctgcta tcagctgggt acgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcgaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagcctcc      300

caaagcagga gctcgaacta ctactactac ggtctggacg tctggggcca agggaccacg      360

gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660

aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720

gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362


<210>  248
<211>  1362
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047307 HC

<400>  248
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac accaaactac      180

gcacagcagt tccaggacag agtcacgatt accgcggacg aatccacgag gacagcctac      240

atggagctga atagcctgaa atctgaggac acggccgtat attactgtgc gaggggacat      300

ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360

gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660

aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720

gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362


<210>  249
<211>  1362
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047308 HC

<400>  249
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgaa tacagcctac      240

atggagctga gtagcctgag atctgaggac acggccgtgt attactgtgc gaggggacat      300

ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360

gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660

aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720

gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362


<210>  250
<211>  1338
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047309 HC

<400>  250
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaacc cttctggagg caccttcagc acctacgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcaacccta tctttggaac agcaaactac      180

gcacagaagt tccagggcag agtcacaatt accgcggacg aatccacgag tccaggctac      240

ctggagctga gcagcctgag atctgaggac acggccgttt attactgtgc gagaggggga      300

gcagtgggtt ttgcctattg gggccaggga accctggtca ccgtctcctc agcgtcgacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga gagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaag ccgaaggggc cccgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccaagc agcatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ccccgggt                                                   1338


<210>  251
<211>  1362
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047310 HC

<400>  251
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc agatatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac atcaaactac      180

gcacagaagt tccagggcag agtcacgatt aaagcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagggggc      300

aacagctgga ccactagttt gtactactac ggtatggacg tctggggcca agggaccacg      360

gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660

aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720

gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362


<210>  252
<211>  1362
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047311 HC

<400>  252
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180

gcacagcagt tccaggacag agtcacgatt accgcggacg aatccacgag gacagcctac      240

atggagctga atagcctgaa atctgaggac acggctgtat attactgtgc gaggggacat      300

ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360

gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660

aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720

gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362


<210>  253
<211>  1362
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047312 HC

<400>  253
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac accaaactac      180

gcacagcagt tccaggacag agtcacgatt accgcggacg aatccacgag gacagcctac      240

atggagctga atagcctgaa atctgaggac acggccgtat attactgtgc gaggggacat      300

ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360

gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660

aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720

gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362


<210>  254
<211>  1362
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047313 HC

<400>  254
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac accaaactac      180

gcacagcggt tccaggacag agtcacgatt accgcggacg aatccacgag gacagcctac      240

atggagctga gtagcctgag atctgaggac acggccgtgt attactgtgc gaggggacat      300

ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360

gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660

aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720

gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362


<210>  255
<211>  1362
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047314 HC

<400>  255
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac accaaactac      180

gcacagcagt tccaggacag agtcacgatt accgcggacg aatccacgag gacagcctac      240

atggagctga atagcctgaa atctgaggac acggccgtat attactgtgc gaggggacat      300

ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360

gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660

aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720

gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362


<210>  256
<211>  1362
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047317 HC

<400>  256
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac accaaactac      180

gcacagcagt tccaggacag agtcacgatt accgcggacg aatccacgag gacagcctac      240

atggagctga atagcctgaa atctgaggac acggccgtat attactgtgc gaggggacat      300

ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360

gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660

aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720

gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362


<210>  257
<211>  1362
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047318 HC

<400>  257
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt ccgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac accaaactac      180

gcacagcagt tccaggacag agtcacgatt accgcggacg aatccacgag gacagcctac      240

atggagctga gtagcctgag atctgaggac acggccgtgt attactgtgc gaggggacat      300

ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360

gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660

aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720

gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362


<210>  258
<211>  1362
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047319 HC

<400>  258
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgaa tacagcctac      240

atggagctga gtagcctgag atctgaggac acggccgtgt attactgtgc gaggggacat      300

ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360

gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660

aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720

gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362


<210>  259
<211>  1362
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047320 HC

<400>  259
caggtgcagc tggtgcagtc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagt atctatgtta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctc tctttggtac accaaactac      180

gcacagcagt tccaggacag agtcacgatt accgcggacg aatccacgag gacagcctac      240

atggagctga atagcctgaa atctgaggac acggccgtat attactgtgc gaggggacat      300

ggtccgggga gttcccacta ctcctactac ggtttggacg tctggggcca agggaccacg      360

gtcaccgtct cctcagcgtc gaccaagggc ccatcggtct tccccctggc accctcctcc      420

aagagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      480

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      540

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      600

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      660

aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      720

gaagccgaag gggccccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      780

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      840

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      900

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      960

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc aagcagcatc     1020

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1080

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1140

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1200

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg     1260

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1320

cacaaccact acacgcagaa gagcctctcc ctgtccccgg gt                        1362


<210>  260
<211>  1368
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047322 HC

<400>  260
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagt cttctggagg caccttcagc agctatgctt tcacctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttcgtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagcagccat      300

ttctctggtt cgggaagttc ccactactac tactacggta tgcacgtctg gggccaaggg      360

accacggtca ccgtctcctc agcgtcgacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaag ccgaaggggc cccgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccaagc     1020

agcatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggt                  1368


<210>  261
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047239 LC

<400>  261
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaacca      120

gggaaagctc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaatagtt acccgtacac ttttggccag      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  262
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047246 LC

<400>  262
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaacca      120

gggaaagctc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaatagtt acccgtacac ttttggccag      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  263
<211>  645
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047247 LC

<400>  263
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gagaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgct cactttcggc      300

ggagggacca aggtggagat caaacgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  264
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047248 LC

<400>  264
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacctac tttcggcgga      300

gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  265
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047323 LC

<400>  265
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaacca      120

gggaaagctc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaatagtt acccgatcac cttcggccaa      300

gggacacgac tggagattaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  266
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047328 LC

<400>  266
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaacca      120

gggaaagctc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccgatcac cttcggccaa      300

gggacacgac tggagattaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  267
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047334 LC

<400>  267
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccgctcac tttcggcgga      300

gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  268
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047263 LC

<400>  268
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt accctccgac ttttggccag      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  269
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047265 LC

<400>  269
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  270
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047289 LC

<400>  270
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaatagtt accctctcac tttcggcgga      300

gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  271
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047290 LC

<400>  271
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  272
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047291 LC

<400>  272
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  273
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047292 LC

<400>  273
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  274
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047294 LC

<400>  274
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcggtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccgctcac tttcggcgga      300

gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  275
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047296 LC

<400>  275
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccgatcac cttcggccaa      300

gggacacgac tggagattaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  276
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047297 LC

<400>  276
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcataaacca      120

gggaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccgctcac tttcggcgga      300

gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  277
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047299 LC

<400>  277
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccgtggac gttcggccaa      300

gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  278
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047300 LC

<400>  278
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatccatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccgctcac tttcggcgga      300

gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  279
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047301 LC

<400>  279
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  280
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047302 LC

<400>  280
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt accctctcac tttcggcgga      300

gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  281
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047305 LC

<400>  281
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  282
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047306 LC

<400>  282
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt accctctcac tttcggcgga      300

gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  283
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047307 LC

<400>  283
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt accctctcac tttcggcgga      300

gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  284
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047308 LC

<400>  284
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  285
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047309 LC

<400>  285
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcataaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttacta ttgtcaacag gctaatagtt tcccgttcac tttcggcgga      300

gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  286
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047310 LC

<400>  286
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacggat tacactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccgctcac tttcggcgga      300

gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  287
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047311 LC

<400>  287
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gggaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccgctcac tttcggcgga      300

gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  288
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047312 LC

<400>  288
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcataaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  289
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047313 LC

<400>  289
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcataaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccctggac gttcggccaa      300

gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  290
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047314 LC

<400>  290
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  291
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047317 LC

<400>  291
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatggt gcatccagca gggccactgg catcccagac      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct      240

gaagattttg cagtgtatta ctgtcagcag tatggtagct caccgctcac tttcggcgga      300

gggaccaagg tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  292
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047318 LC

<400>  292
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcataaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  293
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047319 LC

<400>  293
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcataaacca      120

gggaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  294
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047320 LC

<400>  294
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcataaacca      120

gggaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  295
<211>  642
<212>  DNA
<213>  artificial sequence

<220>
<223>  P1-047322 LC

<400>  295
gacatccaga tgacccagtc tccaacctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggtttagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt acccgtacac ttttggccag      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


