                         SEQUENCE LISTING

<110>  GEISINGER HEALTH
 
<120>  COMPOSITIONS AND METHODS OF TREATMENT FOR BREAST CANCER INVOLVING
        A NOVEL CAPERALPHA-MLL1 COMPLEX

<130>  0068623-001694

<150>  US 62/874,239
<151>  2019-07-15

<150>  US 62/935,910
<151>  2019-11-15

<160>  116   

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys Asn Lys 
1               5                   10                  15      


His Gly Gly Val 
            20  


<210>  2
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Ile Lys Asp Asp Val Ile Glu Glu Cys Asn Lys His Gly Gly Val 
1               5                   10                  15      


Ile His Ile Tyr Val Asp Lys Asn Ser Ala Gln Gly Asn Val Tyr Val 
            20                  25                  30          


<210>  3
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  3

Leu His Gly Arg Trp Phe Ala Gly Lys Met Ile Thr Ala Ala Tyr Val 
1               5                   10                  15      


Pro Leu 
        


<210>  4
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  4

Gly Trp Asp Thr Ile Glu Glu Cys Asn Lys His Gly Gly Val Ile His 
1               5                   10                  15      


Ile Tyr Val Asp Lys Asn Ser Ala Gln Gly Asn Val Tyr Val Lys Cys 
            20                  25                  30          


Pro Ser Ile Ala Ala Ala Ile Ala Ala Val Asn Ala Leu His Gly Arg 
        35                  40                  45              


Trp Phe Ala Gly Lys Met Ile Thr Ala Ala Tyr Val Pro Leu Pro Thr 
    50                  55                  60                  


<210>  5
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  5

Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Gly Val Ile His 
1               5                   10                  15      


Ile Tyr Val Asp Lys Asn Ser Ala Gln Gly Asn Val Tyr Val Lys Cys 
            20                  25                  30          


Pro Ser Ile Ala Ala Ala Ile Ala Ala Val Asn Ala Leu His Gly Arg 
        35                  40                  45              


Trp Phe Ala Gly Lys Met Ile Thr Ala Ala Tyr Val Pro Leu Pro Thr 
    50                  55                  60                  


<210>  6
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  6

Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys Asn Lys 
1               5                   10                  15      


His Gly Gly Val Ile His Lys Asn Ser Ala Gln Gly Asn Val Tyr Val 
            20                  25                  30          


Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala Ala Val Asn Ala Leu His 
        35                  40                  45              


Gly Arg Trp Phe Ala Gly Lys Met Ile Thr Ala Ala Tyr Val Pro Leu 
    50                  55                  60                  


Pro Thr 
65      


<210>  7
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  7

Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys Asn Lys 
1               5                   10                  15      


His Gly Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala Gln Lys 
            20                  25                  30          


Cys Pro Ser Ile Ala Ala Ala Ile Ala Ala Val Asn Ala Leu His Gly 
        35                  40                  45              


Arg Trp Phe Ala Gly Lys Met Ile Thr Ala Ala Tyr Val Pro Leu Pro 
    50                  55                  60                  


Thr 
65  


<210>  8
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  8

Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys Asn Lys 
1               5                   10                  15      


His Gly Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala Gln Gly 
            20                  25                  30          


Asn Val Tyr Val Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala Ala Val 
        35                  40                  45              


Asn Ala Ala Gly Lys Met Ile Thr Ala Ala Tyr Val Pro Leu Pro Thr 
    50                  55                  60                  


<210>  9
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  9

Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys Asn Lys 
1               5                   10                  15      


His Gly Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala Gln Gly 
            20                  25                  30          


Asn Val Tyr Val Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala Ala Val 
        35                  40                  45              


Asn Ala Leu His Gly Arg Trp Phe Ala Gly Lys Met Ile Thr Pro Leu 
    50                  55                  60                  


Pro Thr 
65      


<210>  10
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  10

Ile His Tyr Val Asp Lys Asn Ser Ala Gln Gly Asn Val Tyr Val Lys 
1               5                   10                  15      


Lys Cys Pro Ser 
            20  


<210>  11
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D-amino acid substitutions at K3, V6, E9, K12, V16, H18, V21, 
       N24, Q27, V29

<400>  11

Glu Ile Lys Asp Asp Val Ile Glu Glu Cys Asn Lys His Gly Gly Val 
1               5                   10                  15      


Ile His Ile Tyr Val Asp Lys Asn Ser Ala Gln Gly Asn Val Tyr Val 
            20                  25                  30          


<210>  12
<211>  18
<212>  PRT
<213>  Drosophila melanogaster

<400>  12

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly 
        


<210>  13
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  13

Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys Asn Lys 
1               5                   10                  15      


His Gly Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala Gln Gly 
            20                  25                  30          


Asn Val Tyr Val Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala Ala Val 
        35                  40                  45              


Asn Ala Leu His Gly Arg Trp Phe Ala Gly Lys Met Ile Thr Ala Ala 
    50                  55                  60                  


Tyr Val Pro Leu Pro Thr 
65                  70  


<210>  14
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  14

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly Glu Ile Lys Asp Asp Val Ile Glu Glu Cys Asn Lys His Gly 
            20                  25                  30          


Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala Gln Gly Asn Val 
        35                  40                  45              


Tyr Val His His His His His His 
    50                  55      


<210>  15
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  15

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly Glu Ile Lys Asp Asp Val Ile Glu Glu Cys Asn Lys His Gly 
            20                  25                  30          


Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala Gln Gly Asn Val 
        35                  40                  45              


Tyr Val 
    50  


<210>  16
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D-amino acid substitutions at K21, V24, E27, K30, V34, H36, V39, 
       N42, Q45, V48

<400>  16

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly Glu Ile Lys Asp Asp Val Ile Glu Glu Cys Asn Lys His Gly 
            20                  25                  30          


Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala Gln Gly Asn Val 
        35                  40                  45              


Tyr Val 
    50  


<210>  17
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D-amino acid substitutions at K21, V24, E27, K30, V34, H36, V39, 
       N42, Q45, V48

<400>  17

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly Glu Ile Lys Asp Asp Val Ile Glu Glu Cys Asn Lys His Gly 
            20                  25                  30          


Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala Gln Gly Asn Val 
        35                  40                  45              


Tyr Val His His His His His His 
    50                  55      


<210>  18
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  Xaa
<222>  (19)..(19)
<223>  Xaa is Mini PEG 3

<400>  18

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly Xaa Glu Ile Lys Asp Asp Val Ile Glu Glu Cys Asn Lys His 
            20                  25                  30          


Gly Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala Gln Gly Asn 
        35                  40                  45              


Val Tyr Val His His His His His His 
    50                  55          


<210>  19
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is myristoylation

<400>  19

Xaa Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys 
1               5                   10                  15      


Lys Gly Gly Glu Ile Lys Asp Asp Val Ile Glu Glu Cys Asn Lys His 
            20                  25                  30          


Gly Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala Gln Gly Asn 
        35                  40                  45              


Val Tyr Val His His His His His His 
    50                  55          


<210>  20
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  20

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys 
            20                  25                  30          


Asn Lys His Gly Gly Val 
        35              


<210>  21
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  21

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys 
            20                  25                  30          


Asn Lys His Gly Gly Val His His His His His His 
        35                  40                  


<210>  22
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  22

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Ile His Tyr Val Asp Lys Asn Ser Ala Gln Gly Asn Val Tyr Val 
            20                  25                  30          


Lys Lys Cys Pro Ser 
        35          


<210>  23
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  23

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly Ile His Tyr Val Asp Lys Asn Ser Ala Gln Gly Asn Val Tyr 
            20                  25                  30          


Val Lys Lys Cys Pro Ser His His His His His His 
        35                  40                  


<210>  24
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  24

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly Leu His Gly Arg Trp Phe Ala Gly Lys Met Ile Thr Ala Ala 
            20                  25                  30          


Tyr Val Pro Leu 
        35      


<210>  25
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  25

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly Leu His Gly Arg Trp Phe Ala Gly Lys Met Ile Thr Ala Ala 
            20                  25                  30          


Tyr Val Pro Leu His His His His His His 
        35                  40          


<210>  26
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  26

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Glu Ile Lys Asp 
1               5                   10                  15      


Asp Val Ile Glu Glu Cys Asn Lys His Gly Gly Val Ile His Ile Tyr 
            20                  25                  30          


Val Asp Lys Asn Ser Ala Gln Gly Asn Val Tyr Val 
        35                  40                  


<210>  27
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  27

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Glu Ile Lys Asp 
1               5                   10                  15      


Asp Val Ile Glu Glu Cys Asn Lys His Gly Gly Val Ile His Ile Tyr 
            20                  25                  30          


Val Asp Lys Asn Ser Ala Gln Gly Asn Val Tyr Val His His His His 
        35                  40                  45              


His His 
    50  


<210>  28
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  28

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Glu Ile Lys Asp Asp Val Ile Glu Glu Cys Asn Lys His Gly Gly Val 
            20                  25                  30          


Ile His Ile Tyr Val Asp Lys Asn Ser Ala Gln Gly Asn Val Tyr Val 
        35                  40                  45              


<210>  29
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  29

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Glu Ile Lys Asp Asp Val Ile Glu Glu Cys Asn Lys His Gly Gly Val 
            20                  25                  30          


Ile His Ile Tyr Val Asp Lys Asn Ser Ala Gln Gly Asn Val Tyr Val 
        35                  40                  45              


His His His His His His 
    50                  


<210>  30
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  30

Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys Asn Lys 
1               5                   10                  15      


His Gly Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala Gln Gly 
            20                  25                  30          


Asn Val Tyr Val Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala Ala Val 
        35                  40                  45              


Asn Ala Leu His Gly Arg Trp Phe Ala Gly Lys Met 
    50                  55                  60  


<210>  31
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  31

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys 
            20                  25                  30          


Asn Lys His Gly Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala 
        35                  40                  45              


Gln Gly Asn Val Tyr Val Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala 
    50                  55                  60                  


Ala Val Asn Ala Leu His Gly Arg Trp Phe Ala Gly Lys Met 
65                  70                  75              


<210>  32
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  32

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys Asn Lys 
            20                  25                  30          


His Gly Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala Gln Gly 
        35                  40                  45              


Asn Val Tyr Val Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala Ala Val 
    50                  55                  60                  


Asn Ala Leu His Gly Arg Trp Phe Ala Gly Lys Met Thr Ala Ala Tyr 
65                  70                  75                  80  


Val Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
                85                  90          


<210>  33
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  33

Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys Asn Lys 
1               5                   10                  15      


His Gly Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala Gln Gly 
            20                  25                  30          


Asn Val Tyr Val Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala Ala Val 
        35                  40                  45              


Asn Ala Leu His Gly Arg Trp Phe Ala Gly Lys Met Thr Ala Ala Tyr 
    50                  55                  60                  


Val Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
65                  70                  75      


<210>  34
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  34

Glu Ile Lys Asp Asp Val Ile Glu Glu Cys Asn Lys His Gly Gly Val 
1               5                   10                  15      


Ile His Ile Tyr Val Asp Lys Asn Ser Ala Gln Gly Asn Val Tyr Val 
            20                  25                  30          


Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala Ala Val Asn Ala Leu His 
        35                  40                  45              


Gly Arg Trp Phe Ala Gly Lys Met Ile Thr Ala Ala Tyr Val Pro Leu 
    50                  55                  60                  


<210>  35
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  35

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly Gly Trp Asp Thr Ile Glu Glu Cys Asn Lys His Gly Gly Val 
            20                  25                  30          


Ile His Ile Tyr Val Asp Lys Asn Ser Ala Gln Gly Asn Val Tyr Val 
        35                  40                  45              


Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala Ala Val Asn Ala Leu His 
    50                  55                  60                  


Gly Arg Trp Phe Ala Gly Lys Met Ile Thr Ala Ala Tyr Val Pro Leu 
65                  70                  75                  80  


Pro Thr 
        


<210>  36
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  36

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly Gly Trp Asp Thr Ile Glu Glu Cys Asn Lys His Gly Gly Val 
            20                  25                  30          


Ile His Ile Tyr Val Asp Lys Asn Ser Ala Gln Gly Asn Val Tyr Val 
        35                  40                  45              


Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala Ala Val Asn Ala Leu His 
    50                  55                  60                  


Gly Arg Trp Phe Ala Gly Lys Met Ile Thr Ala Ala Tyr Val Pro Leu 
65                  70                  75                  80  


Pro Thr His His His His His His 
                85              


<210>  37
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  37

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Gly Val 
            20                  25                  30          


Ile His Ile Tyr Val Asp Lys Asn Ser Ala Gln Gly Asn Val Tyr Val 
        35                  40                  45              


Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala Ala Val Asn Ala Leu His 
    50                  55                  60                  


Gly Arg Trp Phe Ala Gly Lys Met Ile Thr Ala Ala Tyr Val Pro Leu 
65                  70                  75                  80  


Pro Thr 
        


<210>  38
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  38

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Gly Val 
            20                  25                  30          


Ile His Ile Tyr Val Asp Lys Asn Ser Ala Gln Gly Asn Val Tyr Val 
        35                  40                  45              


Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala Ala Val Asn Ala Leu His 
    50                  55                  60                  


Gly Arg Trp Phe Ala Gly Lys Met Ile Thr Ala Ala Tyr Val Pro His 
65                  70                  75                  80  


His His His His His 
                85  


<210>  39
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  39

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys 
            20                  25                  30          


Asn Lys His Gly Gly Val Ile His Lys Asn Ser Ala Gln Gly Asn Val 
        35                  40                  45              


Tyr Val Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala Ala Val Asn Ala 
    50                  55                  60                  


Leu His Gly Arg Trp Phe Ala Gly Lys Met Ile Thr Ala Ala Tyr Val 
65                  70                  75                  80  


Pro Leu Pro Thr 
                


<210>  40
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  40

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys 
            20                  25                  30          


Asn Lys His Gly Gly Val Ile His Lys Asn Ser Ala Gln Gly Asn Val 
        35                  40                  45              


Tyr Val Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala Ala Val Asn Ala 
    50                  55                  60                  


Leu His Gly Arg Trp Phe Ala Gly Lys Met Ile Thr Ala Ala Tyr Val 
65                  70                  75                  80  


Pro Leu Pro Thr His His His His His His 
                85                  90  


<210>  41
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  41

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys 
            20                  25                  30          


Asn Lys His Gly Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala 
        35                  40                  45              


Gln Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala Ala Val Asn Ala Leu 
    50                  55                  60                  


His Gly Arg Trp Phe Ala Gly Lys Met Ile Thr Ala Ala Tyr Val Pro 
65                  70                  75                  80  


Leu Pro Thr 
            


<210>  42
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  42

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys 
            20                  25                  30          


Asn Lys His Gly Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala 
        35                  40                  45              


Gln Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala Ala Val Asn Ala Leu 
    50                  55                  60                  


His Gly Arg Trp Phe Ala Gly Lys Met Ile Thr Ala Ala Tyr Val Pro 
65                  70                  75                  80  


Leu Pro Thr His His His His His His 
                85                  


<210>  43
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  43

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys 
            20                  25                  30          


Asn Lys His Gly Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala 
        35                  40                  45              


Gln Gly Asn Val Tyr Val Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala 
    50                  55                  60                  


Ala Val Asn Ala Ala Gly Lys Met Ile Thr Ala Ala Tyr Val Pro Leu 
65                  70                  75                  80  


Pro Thr 
        


<210>  44
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  44

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys 
            20                  25                  30          


Asn Lys His Gly Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala 
        35                  40                  45              


Gln Gly Asn Val Tyr Val Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala 
    50                  55                  60                  


Ala Val Asn Ala Ala Gly Lys Met Ile Thr Ala Ala Tyr Val Pro Leu 
65                  70                  75                  80  


Pro Thr His His His His His His 
                85              


<210>  45
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  45

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys 
            20                  25                  30          


Asn Lys His Gly Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala 
        35                  40                  45              


Gln Gly Asn Val Tyr Val Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala 
    50                  55                  60                  


Ala Val Asn Ala Leu His Gly Arg Trp Phe Ala Gly Lys Met Ile Thr 
65                  70                  75                  80  


Pro Leu Pro Thr 
                


<210>  46
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  46

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys 
            20                  25                  30          


Asn Lys His Gly Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala 
        35                  40                  45              


Gln Gly Asn Val Tyr Val Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala 
    50                  55                  60                  


Ala Val Asn Ala Leu His Gly Arg Trp Phe Ala Gly Lys Met Ile Thr 
65                  70                  75                  80  


Pro Leu Pro Thr His His His His His His 
                85                  90  


<210>  47
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  47

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Gly His His His His His His 
            20                  


<210>  48
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  48
gatccaagaa gtcagagtgc gaagtctcaa gaggacttcg cactctgact tctttttttt       60

gga                                                                     63


<210>  49
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  49
agcttccaaa aaaaagaagt cagagtgcga agtcctcttg agacttcgca ctctgacttc       60

ttg                                                                     63


<210>  50
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  50
aauucuccga acgugucacg uuu                                               23


<210>  51
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  51
acgugacacg uucggagaau uuu                                               23


<210>  52
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  52
gacagaaauu caagacguuu u                                                 21


<210>  53
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  53
aacgucuuga auuucugucu u                                                 21


<210>  54
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  54
gaagcgaagu agagacagau u                                                 21


<210>  55
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  55
ucugucucua cuucgcuucu u                                                 21


<210>  56
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  56
aagauugggu ugccucauau uuu                                               23


<210>  57
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  57
aauaugaggc aacccaaucu uuu                                               23


<210>  58
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  58
aagaagucag agugcgaagu c                                                 21


<210>  59
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  59
ggacaagagt agagagaga                                                    19


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  60
cggaacaggc gtttagagaa                                                   20


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  61
tggcactgct caacttgttc                                                   20


<210>  62
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  62
cagctatcct ctcagatcca tc                                                22


<210>  63
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  63
ccttgtcttt ccggactttc tg                                                22


<210>  64
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  64
ggctttctct gatgtaattc ttgc                                              24


<210>  65
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  65
gtattttggt ctgactgctt gc                                                22


<210>  66
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  66
tggatctgaa gaaatacttg gattcta                                           27


<210>  67
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  67
caatcccctg taggatttgg                                                   20


<210>  68
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  68
ctgcatttgg ctgtgaacta c                                                 21


<210>  69
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  69
acaaactctg ctacttctgg g                                                 21


<210>  70
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  70
ctgcagatgg agcatgttgt                                                   20


<210>  71
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  71
tcttcacgag gaggcttgat                                                   20


<210>  72
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  72
gcatgaggaa acgcatcgct gcctccaagt                                        30


<210>  73
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  73
gcgaccaagt ccttcccact cgtgcacact                                        30


<210>  74
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  74
aaggcggagg agacctgcgc g                                                 21


<210>  75
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  75
atcgtgcggc attgcggc                                                     18


<210>  76
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  76
tgtctgcagc caggagagc                                                    19


<210>  77
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  77
atgcatcaaa caactgtggc ca                                                22


<210>  78
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  78
gtccctctaa agcagctcaa aa                                                22


<210>  79
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  79
ctcccttcaa aagatccaac tg                                                22


<210>  80
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  80
cctgaggcca tttctttcat aga                                               23


<210>  81
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  81
gtcacagtga ctgagcggct aat                                               23


<210>  82
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  82
gatctatgaa taagcctttg gag                                               23


<210>  83
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  83
tttcgtcctg gtatattcgg t                                                 21


<210>  84
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  84
acaaacccat gtttcgaagg                                                   20


<210>  85
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  85
agtgtccaat ggtggaggac                                                   20


<210>  86
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  86
aggatgagct ggctagagag ac                                                22


<210>  87
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  87
cccaccccac ccctgtacta a                                                 21


<210>  88
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  88
gggagacgcc aagacagaca agatcg                                            26


<210>  89
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  89
ggtgaagacc aagaaggcct cagg                                              24


<210>  90
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  90
cccttggtgt tttggagaaa                                                   20


<210>  91
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  91
gagtgtttct tatggtgaag tcca                                              24


<210>  92
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  92
ggccaaattc agataatcga c                                                 21


<210>  93
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  93
ccacttcgta gcatttacgg                                                   20


<210>  94
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  94
gctggtgaaa aggacctct                                                    19


<210>  95
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  95
cacaggacta gaacacctgc                                                   20


<210>  96
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  96
ccatcctcaa gaaggtgttg g                                                 21


<210>  97
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  97
gtgtcccata tccgcaattt tat                                               23


<210>  98
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  98
aaactgggtc gcattgtgg                                                    19


<210>  99
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  99
tctcggctgc tgcattgttc                                                   20


<210>  100
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  100
tgcagctata cccaggctgg                                                   20


<210>  101
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  101
tgcagctata cccaggctgg                                                   20


<210>  102
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  102
cctgctttgt cctttgatgc                                                   20


<210>  103
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  103
tgagtcaatc cctggaaagt c                                                 21


<210>  104
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  104
cggaagagtg tctggagcaa                                                   20


<210>  105
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  105
ggatgaagcg gagtctgga                                                    19


<210>  106
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  106
tgctgacaat catcaccaag ttc                                               23


<210>  107
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  107
tctcccttcg tgtcctggaa                                                   20


<210>  108
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  108
tgggttcgag ttctttgagg                                                   20


<210>  109
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  109
gtccaacgac tcggacatct                                                   20


<210>  110
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  110
ttctgttgat cccacttcac tgt                                               23


<210>  111
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  111
acacacatgc acacacacta ac                                                22


<210>  112
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  112
aaggacctcg gctggaagtg                                                   20


<210>  113
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  113
cccgggttat gctggttgta                                                   20


<210>  114
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  114
gctcgctcaa cgtcaacctc aactcggtg                                         29


<210>  115
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  115
agtggcggct gccctggtcc agcaccacc                                         29


<210>  116
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  116

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Arg Thr Val Phe Cys Met Gln Leu Ala Ala Arg Ile Arg Pro Arg Asp 
            20                  25                  30          


Leu Glu Glu Phe Phe Ser Thr Val Gly Lys Val Arg Asp Val Arg Met 
        35                  40                  45              


Ile Ser Asp Arg Asn Ser Arg Arg Ser Lys Gly Ile Ala Tyr Val Glu 
    50                  55                  60                  


Phe Val Asp Val Ser Ser Val Pro Leu Ala Ile Met Thr Ala Ala Tyr 
65                  70                  75                  80  


Val Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
                85                  90          


