                         SEQUENCE LISTING

<110>  The Research Foundation for The State University of New 
       York
 
<120>  COMPOSITIONS AND METHODS TO BLOCK AND BIND CXCR4 TO MODULATE 
       CELLULAR FUNCTION

<130>  011520.01532

<150>  62/873,665
<151>  2019-07-12

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv#a

<400>  1

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Glu 
            100                 105                 110         


Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ala Ser Gln Val Thr 
        115                 120                 125             


Leu Lys Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
    130                 135                 140                 


Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Tyr Ile His 
145                 150                 155                 160 


Trp Val Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ile Ile 
                165                 170                 175     


Asn Pro Ser Asp Gly Arg Thr Thr Tyr Ala Gln Lys Phe Gln Gly Arg 
            180                 185                 190         


Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Leu Tyr Met Glu Leu 
        195                 200                 205             


Thr Ser Leu Arg Ser Glu Asp Thr Ala Val Cys Gly Arg Gly Gly His 
    210                 215                 220                 


Tyr Ser Asn Tyr Phe Gly Gln Pro Ser Thr Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Val Glu Ala Ser His His His His His His 
                245                 250                 


<210>  2
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv#b

<400>  2

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Glu 
            100                 105                 110         


Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ala Ser Gln Val Thr 
        115                 120                 125             


Leu Lys Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
    130                 135                 140                 


Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Tyr Ile His 
145                 150                 155                 160 


Trp Val Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ile Ile 
                165                 170                 175     


Asn Pro Ser Asp Gly Arg Thr Thr Tyr Ala Gln Lys Phe Gln Gly Arg 
            180                 185                 190         


Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Leu Tyr Met Glu Leu 
        195                 200                 205             


Thr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg Gly 
    210                 215                 220                 


Gly His Tyr Ser Asn Tyr Phe Gly Gln Pro Ser Thr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Val Glu Ala Ser His His His His His His 
                245                 250                 255     


<210>  3
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv#c

<400>  3

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Glu 
            100                 105                 110         


Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ala Ser Gln Val Thr 
        115                 120                 125             


Leu Lys Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
    130                 135                 140                 


Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Tyr Ile His 
145                 150                 155                 160 


Trp Val Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ile Ile 
                165                 170                 175     


Asn Pro Ser Asp Gly Arg Thr Thr Tyr Ala Gln Lys Phe Gln Gly Arg 
            180                 185                 190         


Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Leu Tyr Met Glu Leu 
        195                 200                 205             


Thr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Gly Arg Gly 
    210                 215                 220                 


Gly His Tyr Ser Asn Tyr Phe Gly Gln Pro Ser Thr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Val Glu Ala Ser His His His His His His 
                245                 250                 255     


<210>  4
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv#d

<400>  4

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Gly Ile Thr Ile Ser Cys Ser Gly Ser Gly Ser Asn Ile Gly Ser His 
            20                  25                  30          


Thr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Asp Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Thr Gly Pro 
                85                  90                  95      


Ser Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Glu 
            100                 105                 110         


Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ala Ser Gln Val Thr 
        115                 120                 125             


Leu Lys Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys 
    130                 135                 140                 


Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Tyr Ile His 
145                 150                 155                 160 


Trp Val Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ile Ile 
                165                 170                 175     


Asn Pro Ser Asp Gly Arg Thr Thr Tyr Ala Gln Lys Phe Gln Gly Arg 
            180                 185                 190         


Val Thr Met Thr Arg Asp Ala Ser Thr Ser Thr Leu Tyr Met Glu Leu 
        195                 200                 205             


Thr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Gly Lys Gly 
    210                 215                 220                 


Gly His Tyr Ser Asn Tyr Phe Gly Gln Pro Ser Thr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Val Glu Ala Ser His His His His His His 
                245                 250                 255     


<210>  5
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  5

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Tyr 
1               5                   10              


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  6

Asn Phe Tyr Ile His 
1               5   


<210>  7
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protamine RBM peptide

<400>  7

Arg Ser Gln Ser Arg Ser Arg Tyr Tyr Arg Gln Arg Gln Arg Ser Arg 
1               5                   10                  15      


Arg Arg Arg Arg Arg Ser 
            20          


<210>  8
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CXCR4 scFv#c and protamine RBM peptide fusion protein

<400>  8

Met Leu Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro 
1               5                   10                  15      


Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly 
            20                  25                  30          


Ser Asn Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
65                  70                  75                  80  


Leu Arg Ser Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Thr Trp Asp Asp 
                85                  90                  95      


Ser Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


Gly Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ala Ser Gln 
        115                 120                 125             


Val Thr Leu Lys Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Phe Tyr 
145                 150                 155                 160 


Ile His Trp Val Arg Arg Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Ile Ile Asn Pro Ser Asp Gly Arg Thr Thr Tyr Ala Gln Lys Phe Gln 
            180                 185                 190         


Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Leu Tyr Met 
        195                 200                 205             


Glu Leu Thr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Gly 
    210                 215                 220                 


Arg Gly Gly His Tyr Ser Asn Tyr Phe Gly Gln Pro Ser Thr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Val Asp Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Ser Arg Ser Gln Ser Arg Ser Arg Tyr Tyr Arg Gln Arg 
            260                 265                 270         


Gln Arg Ser Arg Arg Arg Arg Arg Arg Ser Glu Asn Leu Tyr Phe Gln 
        275                 280                 285             


Gly Leu Glu His His His His His His 
    290                 295         


<210>  9
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Pro Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Ser Glu Glu Val 
1               5                   10                  15      


Gly Ser Gly Asp Tyr Asp Ser Asn Lys Glu Pro Cys Phe Arg Asp Glu 
            20                  25                  30          


Asn Val His Phe Asn Arg Ile Phe Leu Pro Thr Ile Tyr Phe 
        35                  40                  45      


<210>  10
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  10
ccctgtatgc ctctggtc                                                     18


<210>  11
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  11
gtctttacgg atgtcaacg                                                    19


<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  12
tttgcttcca tgctaatgcg aaag                                              24


<210>  13
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  13
gctctgttga ggtctaaagg ctccg                                             25


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  14
tgggaaatcg tggaaatgag                                                   20


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  15
ctgaaggact ctggctttgt c                                                 21


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  16
cagaagaatg gaagagtcag                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  17
cagatatgca gggagtcacc                                                   20


<210>  18
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  18
aaaaccagga gatgagaaat gg                                                22


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  19
cggagatgac caccagtagc                                                   20


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  20

Arg Asn Asn Gln Arg Pro Ser 
1               5           


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  21

Ala Ala Trp Asp Asp Ser Leu Asn Gly Val Val 
1               5                   10      


<210>  22
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  22

Ile Ile Asn Pro Ser Asp Gly Arg Thr Thr Tyr Ala Gln 
1               5                   10              


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  23

Gly Gly His Tyr Ser Asn Tyr Phe Gly Gln Pro Ser Thr 
1               5                   10              


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  24

Ala Ala Trp Asp Asp Ser Leu Ser Gly Val Ile 
1               5                   10      


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  25

Ala Thr Trp Asp Asp Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  26
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  26

Ser Gly Ser Gly Ser Asn Ile Gly Ser His Thr Val Ser 
1               5                   10              


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  27

Gly Asn Asn Asn Arg Pro Ser 
1               5           


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  28

Ala Thr Trp Asp Thr Gly Pro Ser Ala Val Val 
1               5                   10      


<210>  29
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAT derived sequence

<400>  29

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
1               5                   10          


