                         SEQUENCE LISTING

<110>  Li, Zijaun
 
<120>  IL-2 COMPOSITIONS AND METHODS OF USE THEREOF

<130>  PRVA-003/02WO

<150>  US 62/908,782
<151>  2019-10-01

<150>  US 62/873,399
<151>  2019-07-12

<160>  441   

<170>  PatentIn version 3.5

<210>  1
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  2
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature human IL-2 with C125S substitution

<400>  2

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  3
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala His Ser Lys Asn Phe His Phe 
65                  70                  75                  80  


Asp Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  4
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val 
1               5                   10                  15      


Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
            20                  25                  30          


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
        35                  40                  45              


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
    50                  55                  60                  


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
65                  70                  75                  80  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
                85                  90                  95      


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
            100                 105                 110         


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
        115                 120                 125             


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
    130                 135                 140                 


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
145                 150                 155                 160 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
                165                 170                 175     


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln 
            180                 185                 190         


Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu 
        195                 200                 205             


Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr 
    210                 215                 220                 


Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
225                 230                 235                 240 


Val Ala Val Ala Gly Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu 
                245                 250                 255     


Ser Gly Leu Thr Trp Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
            260                 265                 270         


<210>  5
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
    210                 215                 


<210>  6
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu 
                165     


<210>  7
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IL-2 mature form with V69A, Q74P and I128T substitutions

<400>  7

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  8
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IL-2 mature form with F42A, Y45A and L72G substitutions

<400>  8

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Gly Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  9
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IL-2 mature form with R38K, F42Q, Y45N, E62L and E68V 
       substitutions

<400>  9

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Lys Met Leu Thr Gln Lys Phe Asn Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Leu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Val Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  10
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IL-2 mature form with R38K, F42Q, Y45E and E68V 
       substitutions

<400>  10

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Lys Met Leu Thr Gln Lys Phe Glu Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Val Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  11
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IL-2 mature form with R38A, F42I, Y45N, E62L and E68V 
       substitutions

<400>  11

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Ala Met Leu Thr Ile Lys Phe Asn Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Leu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Val Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  12
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IL-2 mature form with R38K, F42K, Y45R, E62L and E68V 
       substitutions

<400>  12

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Lys Met Leu Thr Lys Lys Phe Arg Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Leu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Val Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  13
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IL-2 mature form with R38K, F42I, Y45E and E68V 
       substitutions

<400>  13

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Lys Met Leu Thr Ile Lys Phe Glu Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Val Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  14
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IL-2 mature form with R38A, F42A, Y45A and E62A 
       substitutions

<400>  14

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Ala Met Leu Thr Ala Lys Phe Ala Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Ala Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  15
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IL-2 mature form with T3A substitution

<400>  15

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  16
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IL-2 mature form with F42A substitution

<400>  16

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  17
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IL-2 mature form with Y45A susbstitution

<400>  17

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Ala Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  18
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IL-2 mature form with F42A and Y45A substitutions

<400>  18

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Ala Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  19
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IL-2 mature form with E61S substitution

<400>  19

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Ser Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  20
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IL-2Ralpha-sushi (22-187) with K38S substitution

<400>  20

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Ser Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu 
                165     


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  21

Gly Ser Leu Ser Gly Arg Ser Asp Asn His Gly Ser 
1               5                   10          


<210>  22
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  22

Gly Ser Leu Gly Gly Ser Gly Arg Ser Ala Asn Ala Gly Ser 
1               5                   10                  


<210>  23
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  23

Gly Gly Ser Leu Ser Gly Arg Ser Ala Asn Ala Gly Gly Ser 
1               5                   10                  


<210>  24
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  24

Gly Pro Leu Gly Leu Ala Gly Arg Ser Ala Asn Ala Gly Ser 
1               5                   10                  


<210>  25
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  25

Pro Leu Gly Leu Ser Gly Arg Ser Ala Asn Ala Gly Pro Ala 
1               5                   10                  


<210>  26
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  26

Pro Leu Gly Leu Ala Gly Arg Ser Ala Asn Ala Gly Pro Ala 
1               5                   10                  


<210>  27
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  27

Gly Pro Leu Gly Leu Ser Gly Arg Ser Ala Asn Ala Gly Pro Ala Ser 
1               5                   10                  15      


Gly 
    


<210>  28
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  28

Gly Pro Leu Gly Leu Ala Gly Arg Ser Ala Asn Ala Gly Pro Ala Ser 
1               5                   10                  15      


Gly 
    


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  29

Ser Gly Pro Leu Gly Leu Ala Gly Arg Ser Ala Asn Ala Gly Pro Ala 
1               5                   10                  15      


Ser 
    


<210>  30
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  30

Ser Gly Pro Ala Ser Gly Arg Ser Ala Asn Ala Pro Leu Gly Leu Ala 
1               5                   10                  15      


Gly 
    


<210>  31
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  31

Gly Ser Gly Pro Ala Ser Gly Arg Ser Ala Asn Ala Pro Leu Gly Leu 
1               5                   10                  15      


Ala Gly Ser 
            


<210>  32
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  32

Gly Pro Leu Gly Leu Ala Gly Arg Ser Ala Asn Pro Gly Pro Ala Ser 
1               5                   10                  15      


Gly 
    


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  33

Gly Pro Leu Gly Leu Ala Gly Arg Ser Asp Asn His Gly Pro Ala Ser 
1               5                   10                  15      


Gly 
    


<210>  34
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  34

Gly Pro Leu Gly Leu Ala Gly Arg Ser Asp Asn Pro Gly Pro Ala Ser 
1               5                   10                  15      


Gly 
    


<210>  35
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  35

Gly Pro Leu Gly Leu Ala Gly Arg Ser Glu Asn Pro Gly Pro Ala Ser 
1               5                   10                  15      


Gly 
    


<210>  36
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  36

Gly Pro Leu Gly Leu Ala Gly Arg Ser Asp Asn Leu Gly Pro Ala Ser 
1               5                   10                  15      


Gly 
    


<210>  37
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  37

Gly Pro Leu Gly Leu Ala Gly Arg Asn Ala Gln Val Gly Pro Ala Ser 
1               5                   10                  15      


Gly 
    


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  38

Gly Ser Leu Ser Gly Arg Ser Asp Asn Ala Gly Ser 
1               5                   10          


<210>  39
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  39

Gly Ser Leu Ser Gly Arg Ser Asp Asn Asp Gly Ser 
1               5                   10          


<210>  40
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  40

Gly Ser Leu Ser Gly Arg Ser Asp Asn Glu Gly Ser 
1               5                   10          


<210>  41
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  41

Gly Ser Leu Ser Gly Arg Ser Asp Asn Phe Gly Ser 
1               5                   10          


<210>  42
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  42

Gly Ser Leu Ser Gly Arg Ser Asp Asn Gly Gly Ser 
1               5                   10          


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  43

Gly Ser Leu Ser Gly Arg Ser Asp Asn Ile Gly Ser 
1               5                   10          


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  44

Gly Ser Leu Ser Gly Arg Ser Asp Asn Lys Gly Ser 
1               5                   10          


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  45

Gly Ser Leu Ser Gly Arg Ser Asp Asn Leu Gly Ser 
1               5                   10          


<210>  46
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  46

Gly Ser Leu Ser Gly Arg Ser Asp Asn Met Gly Ser 
1               5                   10          


<210>  47
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  47

Gly Ser Leu Ser Gly Arg Ser Asp Asn Asn Gly Ser 
1               5                   10          


<210>  48
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  48

Gly Ser Leu Ser Gly Arg Ser Asp Asn Pro Gly Ser 
1               5                   10          


<210>  49
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  49

Gly Ser Leu Ser Gly Arg Ser Asp Asn Gln Gly Ser 
1               5                   10          


<210>  50
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  50

Gly Ser Leu Ser Gly Arg Ser Asp Asn Arg Gly Ser 
1               5                   10          


<210>  51
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  51

Gly Ser Leu Ser Gly Arg Ser Asp Asn Ser Gly Ser 
1               5                   10          


<210>  52
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  52

Gly Ser Leu Ser Gly Arg Ser Asp Asn Thr Gly Ser 
1               5                   10          


<210>  53
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  53

Gly Ser Leu Ser Gly Arg Ser Asp Asn Val Gly Ser 
1               5                   10          


<210>  54
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  54

Gly Ser Leu Ser Gly Arg Ser Asp Asn Trp Gly Ser 
1               5                   10          


<210>  55
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  55

Gly Ser Leu Ser Gly Arg Ser Asp Asn Tyr Gly Ser 
1               5                   10          


<210>  56
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  56

Gly Ser Leu Ser Gly Arg Ser Ala Asn Asp Gly Ser 
1               5                   10          


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  57

Gly Ser Leu Ser Gly Arg Ser Ala Asn Glu Gly Ser 
1               5                   10          


<210>  58
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  58

Gly Ser Leu Ser Gly Arg Ser Ala Asn Phe Gly Ser 
1               5                   10          


<210>  59
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  59

Gly Ser Leu Ser Gly Arg Ser Ala Asn Gly Ser Ser 
1               5                   10          


<210>  60
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  60

Gly Ser Leu Ser Gly Arg Ser Ala Asn His Gly Ser 
1               5                   10          


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  61

Gly Ser Leu Ser Gly Arg Ser Ala Asn Ile Gly Ser 
1               5                   10          


<210>  62
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  62

Gly Ser Leu Ser Gly Arg Ser Ala Asn Lys Gly Ser 
1               5                   10          


<210>  63
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  63

Gly Ser Leu Ser Gly Arg Ser Ala Asn Leu Gly Ser 
1               5                   10          


<210>  64
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  64

Gly Ser Leu Ser Gly Arg Ser Ala Asn Met Gly Ser 
1               5                   10          


<210>  65
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  65

Gly Ser Leu Ser Gly Arg Ser Ala Asn Asn Gly Ser 
1               5                   10          


<210>  66
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  66

Gly Ser Leu Ser Gly Arg Ser Ala Asn Pro Gly Ser 
1               5                   10          


<210>  67
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  67

Gly Ser Leu Ser Gly Arg Ser Ala Asn Gln Ser Ser 
1               5                   10          


<210>  68
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  68

Gly Ser Leu Ser Gly Arg Ser Ala Asn Arg Gly Ser 
1               5                   10          


<210>  69
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  69

Gly Ser Leu Ser Gly Arg Ser Ala Asn Ser Gly Ser 
1               5                   10          


<210>  70
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  70

Gly Ser Leu Ser Gly Arg Ser Ala Asn Thr Gly Ser 
1               5                   10          


<210>  71
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  71

Gly Ser Leu Ser Gly Arg Ser Ala Asn Val Gly Ser 
1               5                   10          


<210>  72
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  72

Gly Ser Leu Ser Gly Arg Ser Ala Asn Trp Gly Ser 
1               5                   10          


<210>  73
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  73

Gly Ser Leu Ser Gly Arg Ser Ala Asn Tyr Ser Ser 
1               5                   10          


<210>  74
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  74

Gly Pro Leu Gly Leu Ala Gly Arg Ser Asp Asn His Ser Gly 
1               5                   10                  


<210>  75
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  75

Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp Asn Arg 
1               5                   10              


<210>  76
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  76

Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp Asn Arg Gly Ser 
1               5                   10                  15  


<210>  77
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  77

Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp Asn Arg Gly 
1               5                   10                  15      


Ser 
    


<210>  78
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  78

Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp Asn Arg Gly Ala 
1               5                   10                  15  


<210>  79
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  79

Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp Asn Gln Gly Ala 
1               5                   10                  15  


<210>  80
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  80

Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp Asn Tyr Gly Ala 
1               5                   10                  15  


<210>  81
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  81

Gly Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp Asn Gln Gly 
1               5                   10                  15  


<210>  82
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  82

Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp Asn Gln Gly 
1               5                   10                  15      


Ala 
    


<210>  83
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  83

Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp Asn Gln 
1               5                   10                  15      


Gly Gly Ala 
            


<210>  84
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  84

Gly Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp Asn 
1               5                   10                  15      


Gln Gly Gly Gly Ala 
            20      


<210>  85
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  85

Gly Gly Ser Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp 
1               5                   10                  15      


Asn Gln Gly Gly Gly Gly Ala 
            20              


<210>  86
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  86

Gly Gly Ser Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser 
1               5                   10                  15      


Asp Asn Gln Gly Gly Ser Gly Gly Ala 
            20                  25  


<210>  87
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  87

Gly Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp Asn Arg Gly 
1               5                   10                  15  


<210>  88
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  88

Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp Asn Arg Gly 
1               5                   10                  15      


Ala 
    


<210>  89
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  89

Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp Asn Arg 
1               5                   10                  15      


Gly Gly Ala 
            


<210>  90
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  90

Gly Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp Asn 
1               5                   10                  15      


Arg Gly Gly Gly Ala 
            20      


<210>  91
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  91

Gly Gly Ser Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp 
1               5                   10                  15      


Asn Arg Gly Gly Gly Gly Ala 
            20              


<210>  92
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  92

Gly Gly Ser Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser 
1               5                   10                  15      


Asp Asn Arg Gly Gly Ser Gly Gly Ala 
            20                  25  


<210>  93
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  93

Gly Gly Ser Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser 
1               5                   10                  15      


Asp Asn His Gly Gly Ser Gly Gly Ala 
            20                  25  


<210>  94
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  94

Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp Asn Gln Gly Ala 
1               5                   10                  15  


<210>  95
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  95

Gly Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp Asn Gln Gly Ala 
1               5                   10                  15      


<210>  96
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  96

Gly Gly Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp Asn Gln Gly 
1               5                   10                  15      


Ala 
    


<210>  97
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  97

Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp Asn His 
1               5                   10                  15      


Gly Gly Ala 
            


<210>  98
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  98

Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp Asn Gln 
1               5                   10                  15      


Gly Gly Ala 
            


<210>  99
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  99

Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp Asn Arg 
1               5                   10                  15      


Gly Gly Ala 
            


<210>  100
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  100

Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp Asn Thr 
1               5                   10                  15      


Gly Gly Ala 
            


<210>  101
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  101

Gly Gly Gly Ser Gly Arg Ser Asp Asn His Gly Gly Ala 
1               5                   10              


<210>  102
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  102

Gly Gly Gly Gly Ser Gly Arg Ser Asp Asn His Gly Gly Ala 
1               5                   10                  


<210>  103
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  103

Gly Gly Gly Gly Ser Ser Gly Arg Ser Asp Asn His Gly Gly Gly Ala 
1               5                   10                  15      


<210>  104
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  104

Gly Gly Ser Gly Gly Ser Ser Gly Arg Ser Asp Asn His Gly Gly Gly 
1               5                   10                  15      


Gly Ala 
        


<210>  105
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  105

Gly Gly Ser Gly Gly Ser Ser Gly Arg Ser Asp Asn His Gly Gly Ser 
1               5                   10                  15      


Gly Gly Ala 
            


<210>  106
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  106

Gly Gly Ser Gly Arg Ser Asp Asn His Gly Gly Ala 
1               5                   10          


<210>  107
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  107

Gly Gly Ser Gly Gly Ser Gly Arg Ser Asp Asn His Gly Gly Ala 
1               5                   10                  15  


<210>  108
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  108

Gly Ser Pro Leu Gly Leu Ala Gly Ser 
1               5                   


<210>  109
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  109

Gly Gly Ser Pro Leu Gly Leu Ala Gly Gly Ser 
1               5                   10      


<210>  110
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  110

Gly Gly Ser Pro Leu Gly Leu Ala Gly Gly Gly Ser 
1               5                   10          


<210>  111
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  111

Gly Gly Gly Ser Pro Leu Gly Leu Ala Gly Gly Gly Ser 
1               5                   10              


<210>  112
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  112

Gly Gly Gly Ser Pro Leu Gly Leu Ala Gly Gly Gly Gly Ser 
1               5                   10                  


<210>  113
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  113

Gly Gly Ser Gly Gly Gly Pro Leu Gly Leu Ala Gly Gly Gly Ala 
1               5                   10                  15  


<210>  114
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  114

Gly Gly Ser Gly Gly Ser Gly Arg Ser Asp Asn His Gly Gly Ala 
1               5                   10                  15  


<210>  115
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  115

Gly Arg Gly Asp 
1               


<210>  116
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  116

Gly Arg Gly Asp Asn 
1               5   


<210>  117
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  117

Gly Arg Gly Asp Ser 
1               5   


<210>  118
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  118

Gly Arg Gly Asp Ser Pro Lys 
1               5           


<210>  119
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  119

Ala Ala Pro Val 
1               


<210>  120
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  120

Ala Ala Pro Leu 
1               


<210>  121
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  121

Ala Ala Pro Phe 
1               


<210>  122
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  122

Ala Ala Pro Ala 
1               


<210>  123
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  123

Ala Tyr Leu Val 
1               


<210>  124
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  X = Any amino acid

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  X = Any amino acid

<400>  124

Gly Pro Xaa Gly Pro Xaa 
1               5       


<210>  125
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker


<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  X = Any amino acid

<400>  125

Leu Gly Pro Xaa 
1               


<210>  126
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  X = Any amino acid

<400>  126

Gly Pro Ile Gly Pro Xaa 
1               5       


<210>  127
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker


<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  X = Any amino acid

<400>  127

Ala Pro Gly Leu Xaa 
1               5   


<210>  128
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  X = Any amino acid

<400>  128

Pro Leu Gly Pro Asp Arg Xaa 
1               5           


<210>  129
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  X = Any amino acid

<400>  129

Pro Leu Gly Leu Leu Gly Xaa 
1               5           


<210>  130
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  130

Pro Gln Gly Ile Ala Gly Trp 
1               5           


<210>  131
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  131

Pro Leu Gly Cys His 
1               5   


<210>  132
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  132

Pro Leu Gly Leu Tyr Ala 
1               5       


<210>  133
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  133

Pro Leu Ala Leu Trp Ala Arg 
1               5           


<210>  134
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  134

Pro Leu Ala Tyr Trp Ala Arg 
1               5           


<210>  135
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  135

Pro Tyr Ala Tyr Tyr Met Arg 
1               5           


<210>  136
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  136

Pro Leu Gly Met Tyr Ser Arg 
1               5           


<210>  137
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  137

Gly Asp Lys Pro 
1               


<210>  138
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  138

Gly Ser Asp Lys Pro 
1               5   


<210>  139
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  139

Val Leu Ala Leu 
1               


<210>  140
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - cleavable peptide linker

<400>  140

Gly Phe Leu Gly 
1               


<210>  141
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  141

Gly Ser Gly Ser 
1               


<210>  142
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  142

Gly Gly Ser Gly 
1               


<210>  143
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  143

Gly Gly Gly Ser 
1               


<210>  144
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  144

Gly Gly Gly Gly Ser 
1               5   


<210>  145
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  145

Gly Asn Gly Asn 
1               


<210>  146
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  146

Gly Gly Asn Gly 
1               


<210>  147
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  147

Gly Gly Gly Asn 
1               


<210>  148
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  148

Gly Gly Gly Gly Asn 
1               5   


<210>  149
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  149

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  150
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  150

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser 
            20          


<210>  151
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  151

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  152
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  152

Asp Ala Ala Ala Lys Glu Ala Ala Ala Lys Asp Ala Ala Ala Arg Glu 
1               5                   10                  15      


Ala Ala Ala Arg Asp Ala Ala Ala Lys 
            20                  25  


<210>  153
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  153

Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
1               5                   10                  


<210>  154
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  154

Asp Gly Gly Gly Ser 
1               5   


<210>  155
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  155

Thr Gly Glu Lys Pro 
1               5   


<210>  156
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  156

Gly Gly Arg Arg 
1               


<210>  157
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  157

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  


<210>  158
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  158

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  159
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  159

Gly Gly Arg Arg Gly Gly Gly Ser 
1               5               


<210>  160
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  160

Leu Arg Gln Arg Asp Gly Glu Arg Pro 
1               5                   


<210>  161
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  161

Leu Arg Gln Lys Asp Gly Gly Gly Ser Glu Arg Pro 
1               5                   10          


<210>  162
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - non-cleavable peptide linker

<400>  162

Leu Arg Gln Lys Asp Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10              


<210>  163
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mad in Lab - affinity purification peptide tag

<400>  163

Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
1               5                   10      


<210>  164
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mad in Lab - affinity purification peptide tag

<400>  164

His Thr Thr Pro His His 
1               5       


<210>  165
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mad in Lab - affinity purification peptide tag

<400>  165

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  166
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mad in Lab - affinity purification peptide tag

<400>  166

Ala Trp Ala His Pro Gln Pro Gly Gly 
1               5                   


<210>  167
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mad in Lab - affinity purification peptide tag

<400>  167

Lys Glu Thr Ala Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser 
1               5                   10                  15  


<210>  168
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mad in Lab - affinity purification peptide tag

<400>  168

Asn Ala Asn Asn Pro Asp Trp Asp Phe 
1               5                   


<210>  169
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mad in Lab - affinity purification peptide tag

<400>  169

Cys Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10      


<210>  170
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mad in Lab - affinity purification peptide tag

<400>  170

Lys Pro Pro Thr Pro Pro Pro Glu Pro Glu Thr 
1               5                   10      


<210>  171
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mad in Lab - affinity purification peptide tag

<400>  171

Gln Pro Glu Leu Ala Pro Glu Asp 
1               5               


<210>  172
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mad in Lab - affinity purification peptide tag

<400>  172

Lys Asp His Leu Ile His Asn Val His Lys Glu Phe His Ala His Ala 
1               5                   10                  15      


His Asn Lys 
            


<210>  173
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mad in Lab - affinity purification peptide tag

<400>  173

Asp Tyr Lys Asp Asp Asp Lys 
1               5           


<210>  174
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mad in Lab - affinity purification peptide tag

<400>  174

Ser Ser Thr Ser Ser Asp Phe Arg Asp Arg 
1               5                   10  


<210>  175
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mad in Lab - affinity purification peptide tag

<400>  175

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  176
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mad in Lab - affinity purification peptide tag

<400>  176

Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly 
1               5                   10      


<210>  177
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mad in Lab - affinity purification peptide tag

<400>  177

Thr Asp Phe Tyr Leu Lys 
1               5       


<210>  178
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mad in Lab - affinity purification peptide tag

<400>  178

Asp Thr Tyr Arg Tyr Ile 
1               5       


<210>  179
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1522 Activatable Proprotein construct

<400>  179

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Glu Leu Cys Asp Asp Asp 
    130                 135                 140                 


Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu 
145                 150                 155                 160 


Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys 
                165                 170                 175     


Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser 
            180                 185                 190         


Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr 
        195                 200                 205             


Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr 
    210                 215                 220                 


Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly 
225                 230                 235                 240 


His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile 
                245                 250                 255     


Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly 
            260                 265                 270         


Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr 
        275                 280                 285             


His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
    290                 295                 300                 


Gly Gly Gly Gly Ser His His His His His His 
305                 310                 315 


<210>  180
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1523 Activatable Proprotein construct

<400>  180

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Ser Glu Asn Leu Tyr Phe Gln 
225                 230                 235                 240 


Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
                245                 250                 255     


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
            260                 265                 270         


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
        275                 280                 285             


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
    290                 295                 300                 


Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn 
305                 310                 315                 320 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
                325                 330                 335     


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
            340                 345                 350         


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser 
        355                 360                 365             


Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Glu Leu Cys 
    370                 375                 380                 


Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala 
385                 390                 395                 400 


Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg 
                405                 410                 415     


Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser 
            420                 425                 430         


His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg 
        435                 440                 445             


Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg 
    450                 455                 460                 


Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser 
465                 470                 475                 480 


Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr 
                485                 490                 495     


Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys 
            500                 505                 510         


Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys 
        515                 520                 525             


Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys 
    530                 535                 540                 


Thr Gly Glu 
545         


<210>  181
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1523 cleaved protein construct

<400>  181

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Ser Glu Asn Leu Tyr Phe Gln 
225                 230                 235                 240 


<210>  182
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1523 cleaved protein construct

<400>  182

Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
1               5                   10                  15      


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
            20                  25                  30          


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
        35                  40                  45              


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
    50                  55                  60                  


Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn 
65                  70                  75                  80  


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
                85                  90                  95      


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
            100                 105                 110         


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser 
        115                 120                 125             


Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Glu Leu Cys 
    130                 135                 140                 


Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala 
145                 150                 155                 160 


Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg 
                165                 170                 175     


Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser 
            180                 185                 190         


His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg 
        195                 200                 205             


Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg 
    210                 215                 220                 


Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser 
225                 230                 235                 240 


Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr 
                245                 250                 255     


Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys 
            260                 265                 270         


Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys 
        275                 280                 285             


Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys 
    290                 295                 300                 


Thr Gly Glu 
305         


<210>  183
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1523 cleaved protein construct

<400>  183

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Ser Glu Asn Leu Tyr Phe Gln 
225                 230                 235                 240 


Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
                245                 250                 255     


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
            260                 265                 270         


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
        275                 280                 285             


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
    290                 295                 300                 


Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn 
305                 310                 315                 320 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
                325                 330                 335     


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
            340                 345                 350         


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser 
        355                 360                 365             


Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Glu Leu Cys 
    370                 375                 380                 


Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala 
385                 390                 395                 400 


Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg 
                405                 410                 415     


Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser 
            420                 425                 430         


His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg 
        435                 440                 445             


Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg 
    450                 455                 460                 


Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser 
465                 470                 475                 480 


Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr 
                485                 490                 495     


Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys 
            500                 505                 510         


Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys 
        515                 520                 525             


Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys 
    530                 535                 540                 


Thr Gly Glu 
545         


<210>  184
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1523 cleaved protein construct

<400>  184

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Ser Glu Asn Leu Tyr Phe Gln 
225                 230                 235                 240 


<210>  185
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1523 cleaved protein construct

<400>  185

Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
1               5                   10                  15      


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
            20                  25                  30          


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
        35                  40                  45              


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
    50                  55                  60                  


Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn 
65                  70                  75                  80  


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
                85                  90                  95      


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
            100                 105                 110         


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser 
        115                 120                 125             


Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Glu Leu Cys 
    130                 135                 140                 


Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala 
145                 150                 155                 160 


Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg 
                165                 170                 175     


Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser 
            180                 185                 190         


His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg 
        195                 200                 205             


Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg 
    210                 215                 220                 


Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser 
225                 230                 235                 240 


Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr 
                245                 250                 255     


Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys 
            260                 265                 270         


Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys 
        275                 280                 285             


Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys 
    290                 295                 300                 


Thr Gly Glu 
305         


<210>  186
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1524 Activatable Proprotein construct

<400>  186

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Glu Leu Cys Asp Asp Asp 
    130                 135                 140                 


Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu 
145                 150                 155                 160 


Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys 
                165                 170                 175     


Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser 
            180                 185                 190         


Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr 
        195                 200                 205             


Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr 
    210                 215                 220                 


Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly 
225                 230                 235                 240 


His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile 
                245                 250                 255     


Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly 
            260                 265                 270         


Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr 
        275                 280                 285             


His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
    290                 295                 300                 


Gly Ser Glu Asn Leu Tyr Phe Gln Gly Glu Pro Lys Ser Ser Asp Lys 
305                 310                 315                 320 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                325                 330                 335     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            340                 345                 350         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        355                 360                 365             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    370                 375                 380                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
385                 390                 395                 400 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                405                 410                 415     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            420                 425                 430         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        435                 440                 445             


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    450                 455                 460                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
465                 470                 475                 480 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                485                 490                 495     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            500                 505                 510         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        515                 520                 525             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    530                 535                 540                 


Lys 
545 


<210>  187
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1525 Activatable Proprotein construct

<400>  187

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala 
145                 150                 155                 160 


Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly 
                165                 170                 175     


Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn 
            180                 185                 190         


Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala 
        195                 200                 205             


Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys 
    210                 215                 220                 


Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln 
225                 230                 235                 240 


Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu 
                245                 250                 255     


Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr 
            260                 265                 270         


Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser 
        275                 280                 285             


Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu 
    290                 295                 300                 


Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser His His His His His His 
305                 310                 315                 320 


<210>  188
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1526 Activatable Proprotein construct

<400>  188

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Ser Glu Asn Leu Tyr Phe Gln 
225                 230                 235                 240 


Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
                245                 250                 255     


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
            260                 265                 270         


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
        275                 280                 285             


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
    290                 295                 300                 


Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn 
305                 310                 315                 320 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
                325                 330                 335     


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
            340                 345                 350         


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser 
        355                 360                 365             


Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr 
385                 390                 395                 400 


Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys 
                405                 410                 415     


Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys 
            420                 425                 430         


Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr 
        435                 440                 445             


Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu 
    450                 455                 460                 


Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro 
465                 470                 475                 480 


Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp 
                485                 490                 495     


Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met 
            500                 505                 510         


Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro 
        515                 520                 525             


Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln 
    530                 535                 540                 


Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550         


<210>  189
<211>  550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1527 Activatable Proprotein construct

<400>  189

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala 
145                 150                 155                 160 


Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly 
                165                 170                 175     


Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn 
            180                 185                 190         


Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala 
        195                 200                 205             


Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys 
    210                 215                 220                 


Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln 
225                 230                 235                 240 


Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu 
                245                 250                 255     


Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr 
            260                 265                 270         


Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser 
        275                 280                 285             


Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu 
    290                 295                 300                 


Ile Cys Thr Gly Glu Gly Ser Glu Asn Leu Tyr Phe Gln Gly Glu Pro 
305                 310                 315                 320 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                325                 330                 335     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            340                 345                 350         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        355                 360                 365             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    370                 375                 380                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
385                 390                 395                 400 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                405                 410                 415     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            420                 425                 430         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        435                 440                 445             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    450                 455                 460                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
465                 470                 475                 480 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                485                 490                 495     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            500                 505                 510         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        515                 520                 525             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    530                 535                 540                 


Ser Leu Ser Pro Gly Lys 
545                 550 


<210>  190
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1528 Activatable Proprotein construct

<400>  190

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser 
                165                 170                 175     


Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu 
            180                 185                 190         


Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr 
        195                 200                 205             


Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu 
    210                 215                 220                 


Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Ala 
225                 230                 235                 240 


Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu 
                245                 250                 255     


Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr 
            260                 265                 270         


Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe 
        275                 280                 285             


Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr Ile Ser Thr Leu Thr 
    290                 295                 300                 


Gly Gly Gly Gly Ser His His His His His His 
305                 310                 315 


<210>  191
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1529 Activatable Proprotein construct

<400>  191

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Ser Glu Asn Leu Tyr Phe Gln 
225                 230                 235                 240 


Gly Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala 
                245                 250                 255     


Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu 
            260                 265                 270         


Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu 
        275                 280                 285             


Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys 
    290                 295                 300                 


Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro 
305                 310                 315                 320 


Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln 
                325                 330                 335     


Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro 
            340                 345                 350         


Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln 
        355                 360                 365             


Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly 
    370                 375                 380                 


Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr 
385                 390                 395                 400 


Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser Ala Pro 
                405                 410                 415     


Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu 
            420                 425                 430         


Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro 
        435                 440                 445             


Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala 
    450                 455                 460                 


Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu 
465                 470                 475                 480 


Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu Arg Pro 
                485                 490                 495     


Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly 
            500                 505                 510         


Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile 
        515                 520                 525             


Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr Ile Ser 
    530                 535                 540                 


Thr Leu Thr 
545         


<210>  192
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1530 Activatable Proprotein construct

<400>  192

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser 
                165                 170                 175     


Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu 
            180                 185                 190         


Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr 
        195                 200                 205             


Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu 
    210                 215                 220                 


Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Ala 
225                 230                 235                 240 


Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu 
                245                 250                 255     


Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr 
            260                 265                 270         


Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe 
        275                 280                 285             


Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr Ile Ser Thr Leu Thr 
    290                 295                 300                 


Gly Ser Glu Asn Leu Tyr Phe Gln Gly Glu Pro Lys Ser Ser Asp Lys 
305                 310                 315                 320 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                325                 330                 335     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            340                 345                 350         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        355                 360                 365             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    370                 375                 380                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
385                 390                 395                 400 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                405                 410                 415     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            420                 425                 430         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        435                 440                 445             


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    450                 455                 460                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
465                 470                 475                 480 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                485                 490                 495     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            500                 505                 510         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        515                 520                 525             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    530                 535                 540                 


Lys 
545 


<210>  193
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1531 Activatable Proprotein construct

<400>  193

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
            180                 185                 190         


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
        195                 200                 205             


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
    210                 215                 220                 


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
225                 230                 235                 240 


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
                245                 250                 255     


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
            260                 265                 270         


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
        275                 280                 285             


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
    290                 295                 300                 


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser His His His His His His 
305                 310                 315                 320 


<210>  194
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1532 Activatable Proprotein construct

<400>  194

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Ser Glu Asn Leu Tyr Phe Gln 
225                 230                 235                 240 


Gly Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala 
                245                 250                 255     


Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu 
            260                 265                 270         


Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu 
        275                 280                 285             


Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys 
    290                 295                 300                 


Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro 
305                 310                 315                 320 


Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln 
                325                 330                 335     


Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro 
            340                 345                 350         


Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln 
        355                 360                 365             


Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly 
    370                 375                 380                 


Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr 
385                 390                 395                 400 


Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
            420                 425                 430         


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
        435                 440                 445             


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
    450                 455                 460                 


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
465                 470                 475                 480 


Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn 
                485                 490                 495     


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
            500                 505                 510         


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
        515                 520                 525             


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser 
    530                 535                 540                 


Gln Ser Thr Ile Ser Thr Leu Thr 
545                 550         


<210>  195
<211>  550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1533 Activatable Proprotein construct

<400>  195

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
            180                 185                 190         


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
        195                 200                 205             


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
    210                 215                 220                 


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
225                 230                 235                 240 


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
                245                 250                 255     


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
            260                 265                 270         


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
        275                 280                 285             


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
    290                 295                 300                 


Ile Ser Thr Leu Thr Gly Ser Glu Asn Leu Tyr Phe Gln Gly Glu Pro 
305                 310                 315                 320 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                325                 330                 335     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            340                 345                 350         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        355                 360                 365             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    370                 375                 380                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
385                 390                 395                 400 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                405                 410                 415     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            420                 425                 430         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        435                 440                 445             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    450                 455                 460                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
465                 470                 475                 480 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                485                 490                 495     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            500                 505                 510         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        515                 520                 525             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    530                 535                 540                 


Ser Leu Ser Pro Gly Lys 
545                 550 


<210>  196
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1630 Activatable Proprotein construct

<400>  196

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Ser Glu Asn Leu Tyr Phe Gln Gly Gly Ser 
    130                 135                 140                 


Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
145                 150                 155                 160 


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
                165                 170                 175     


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
            180                 185                 190         


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
        195                 200                 205             


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
    210                 215                 220                 


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
225                 230                 235                 240 


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
                245                 250                 255     


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
            260                 265                 270         


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
        275                 280                 285             


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
    290                 295                 300                 


Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser His His His His His 
305                 310                 315                 320 


His 
    


<210>  197
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1630 cleaved protein construct

<400>  197

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Ser Glu Asn Leu Tyr Phe Gln 
    130                 135                 140     


<210>  198
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1630 cleaved protein construct

<400>  198

Gly Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala 
1               5                   10                  15      


Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu 
            20                  25                  30          


Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu 
        35                  40                  45              


Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys 
    50                  55                  60                  


Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro 
65                  70                  75                  80  


Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln 
                85                  90                  95      


Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro 
            100                 105                 110         


Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln 
        115                 120                 125             


Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly 
    130                 135                 140                 


Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr 
145                 150                 155                 160 


Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser His His 
                165                 170                 175     


His His His His 
            180 


<210>  199
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1630 cleaved protein construct

<400>  199

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Ser Glu Asn Leu Tyr Phe Gln Gly Gly Ser 
    130                 135                 140                 


Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
145                 150                 155                 160 


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
                165                 170                 175     


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
            180                 185                 190         


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
        195                 200                 205             


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
    210                 215                 220                 


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
225                 230                 235                 240 


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
                245                 250                 255     


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
            260                 265                 270         


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
        275                 280                 285             


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
    290                 295                 300                 


Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser His His His His His 
305                 310                 315                 320 


His 
    


<210>  200
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1630 cleaved protein construct

<400>  200

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Ser Glu Asn Leu Tyr Phe Gln 
    130                 135                 140     


<210>  201
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1630 cleaved protein construct

<400>  201

Gly Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala 
1               5                   10                  15      


Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu 
            20                  25                  30          


Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu 
        35                  40                  45              


Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys 
    50                  55                  60                  


Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro 
65                  70                  75                  80  


Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln 
                85                  90                  95      


Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro 
            100                 105                 110         


Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln 
        115                 120                 125             


Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly 
    130                 135                 140                 


Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr 
145                 150                 155                 160 


Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser His His 
                165                 170                 175     


His His His His 
            180 


<210>  202
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1631 Activatable Proprotein construct

<400>  202

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
                245                 250                 255     


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
            260                 265                 270         


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
        275                 280                 285             


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
    290                 295                 300                 


Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe 
305                 310                 315                 320 


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
                325                 330                 335     


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
            340                 345                 350         


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln 
        355                 360                 365             


Ser Thr Ile Ser Thr Leu Thr Gly Ser Glu Asn Leu Tyr Phe Gln Gly 
    370                 375                 380                 


Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr 
385                 390                 395                 400 


Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys 
                405                 410                 415     


Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys 
            420                 425                 430         


Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr 
        435                 440                 445             


Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu 
    450                 455                 460                 


Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro 
465                 470                 475                 480 


Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp 
                485                 490                 495     


Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met 
            500                 505                 510         


Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro 
        515                 520                 525             


Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln 
    530                 535                 540                 


Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550         


<210>  203
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1632 Activatable Proprotein construct

<400>  203

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Ser Glu Asn Leu Tyr Phe Gln Gly Gly Ser 
    130                 135                 140                 


Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
145                 150                 155                 160 


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
                165                 170                 175     


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
            180                 185                 190         


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
        195                 200                 205             


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
    210                 215                 220                 


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
225                 230                 235                 240 


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
                245                 250                 255     


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
            260                 265                 270         


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
        275                 280                 285             


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
    290                 295                 300                 


Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                325                 330                 335     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            340                 345                 350         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        355                 360                 365             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    370                 375                 380                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
385                 390                 395                 400 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                405                 410                 415     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            420                 425                 430         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        435                 440                 445             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    450                 455                 460                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
465                 470                 475                 480 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                485                 490                 495     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            500                 505                 510         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        515                 520                 525             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    530                 535                 540                 


Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550         


<210>  204
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1633 Activatable Proprotein construct

<400>  204

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Gly Ser Glu Asn Leu Tyr Phe Gln Gly Gly 
                165                 170                 175     


Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
            180                 185                 190         


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
        195                 200                 205             


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
    210                 215                 220                 


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
225                 230                 235                 240 


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
                245                 250                 255     


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
            260                 265                 270         


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
        275                 280                 285             


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
    290                 295                 300                 


Thr Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser His His His His His 
305                 310                 315                 320 


His 
    


<210>  205
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1634 Activatable Proprotein construct

<400>  205

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr 
                245                 250                 255     


Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys 
            260                 265                 270         


Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys 
        275                 280                 285             


Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr 
    290                 295                 300                 


Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu 
305                 310                 315                 320 


Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro 
                325                 330                 335     


Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp 
            340                 345                 350         


Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met 
        355                 360                 365             


Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro 
    370                 375                 380                 


Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln 
385                 390                 395                 400 


Pro Gln Leu Ile Cys Thr Gly Glu Gly Ser Glu Asn Leu Tyr Phe Gln 
                405                 410                 415     


Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
            420                 425                 430         


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
        435                 440                 445             


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
    450                 455                 460                 


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
465                 470                 475                 480 


Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn 
                485                 490                 495     


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
            500                 505                 510         


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
        515                 520                 525             


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser 
    530                 535                 540                 


Gln Ser Thr Ile Ser Thr Leu Thr 
545                 550         


<210>  206
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1635 Activatable Proprotein construct

<400>  206

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Gly Ser Glu Asn Leu Tyr Phe Gln Gly Gly 
                165                 170                 175     


Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
            180                 185                 190         


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
        195                 200                 205             


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
    210                 215                 220                 


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
225                 230                 235                 240 


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
                245                 250                 255     


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
            260                 265                 270         


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
        275                 280                 285             


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
    290                 295                 300                 


Thr Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                325                 330                 335     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            340                 345                 350         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        355                 360                 365             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    370                 375                 380                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
385                 390                 395                 400 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                405                 410                 415     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            420                 425                 430         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        435                 440                 445             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    450                 455                 460                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
465                 470                 475                 480 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                485                 490                 495     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            500                 505                 510         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        515                 520                 525             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    530                 535                 540                 


Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550         


<210>  207
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1664 Activatable Proprotein construct

<400>  207

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Ser Gly Ser Glu Asn Leu Tyr Phe Gln Gly 
    130                 135                 140                 


Gly Ser Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His 
145                 150                 155                 160 


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
                165                 170                 175     


Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met 
            180                 185                 190         


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
        195                 200                 205             


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
    210                 215                 220                 


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
225                 230                 235                 240 


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
                245                 250                 255     


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
            260                 265                 270         


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
        275                 280                 285             


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
    290                 295                 300                 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser His 
305                 310                 315                 320 


His His His His His 
                325 


<210>  208
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1665 Activatable Proprotein construct

<400>  208

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
                245                 250                 255     


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
            260                 265                 270         


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
        275                 280                 285             


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
    290                 295                 300                 


Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe 
305                 310                 315                 320 


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
                325                 330                 335     


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
            340                 345                 350         


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln 
        355                 360                 365             


Ser Thr Ile Ser Thr Leu Thr Gly Ser Gly Ser Glu Asn Leu Tyr Phe 
    370                 375                 380                 


Gln Gly Gly Ser Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
385                 390                 395                 400 


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
                405                 410                 415     


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu 
            420                 425                 430         


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
        435                 440                 445             


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
    450                 455                 460                 


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
465                 470                 475                 480 


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
                485                 490                 495     


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
            500                 505                 510         


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
        515                 520                 525             


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
    530                 535                 540                 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555     


<210>  209
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1666 Activatable Proprotein construct

<400>  209

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Ser Gly Ser Glu Asn Leu Tyr Phe Gln Gly 
    130                 135                 140                 


Gly Ser Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His 
145                 150                 155                 160 


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
                165                 170                 175     


Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met 
            180                 185                 190         


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
        195                 200                 205             


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
    210                 215                 220                 


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
225                 230                 235                 240 


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
                245                 250                 255     


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
            260                 265                 270         


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
        275                 280                 285             


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
    290                 295                 300                 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
                325                 330                 335     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            340                 345                 350         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        355                 360                 365             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    370                 375                 380                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
385                 390                 395                 400 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                405                 410                 415     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            420                 425                 430         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        435                 440                 445             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    450                 455                 460                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
465                 470                 475                 480 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                485                 490                 495     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            500                 505                 510         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        515                 520                 525             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    530                 535                 540                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555     


<210>  210
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1667 Activatable Proprotein construct

<400>  210

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Ser Gly Ser Gly Ser Glu Asn Leu Tyr Phe 
    130                 135                 140                 


Gln Gly Gly Ser Gly Ser Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro 
145                 150                 155                 160 


Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr 
                165                 170                 175     


Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly 
            180                 185                 190         


Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp 
        195                 200                 205             


Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln 
    210                 215                 220                 


Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met 
225                 230                 235                 240 


Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys 
                245                 250                 255     


Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His 
            260                 265                 270         


Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg 
        275                 280                 285             


Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly 
    290                 295                 300                 


Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly 
305                 310                 315                 320 


Gly Gly Ser His His His His His His 
                325                 


<210>  211
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1668 Activatable Proprotein construct

<400>  211

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
                245                 250                 255     


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
            260                 265                 270         


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
        275                 280                 285             


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
    290                 295                 300                 


Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe 
305                 310                 315                 320 


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
                325                 330                 335     


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
            340                 345                 350         


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln 
        355                 360                 365             


Ser Thr Ile Ser Thr Leu Thr Gly Ser Gly Ser Gly Ser Glu Asn Leu 
    370                 375                 380                 


Tyr Phe Gln Gly Gly Ser Gly Ser Gly Ser Glu Leu Cys Asp Asp Asp 
385                 390                 395                 400 


Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu 
                405                 410                 415     


Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys 
            420                 425                 430         


Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser 
        435                 440                 445             


Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr 
    450                 455                 460                 


Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr 
465                 470                 475                 480 


Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly 
                485                 490                 495     


His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile 
            500                 505                 510         


Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly 
        515                 520                 525             


Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr 
    530                 535                 540                 


His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555                 560 


<210>  212
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1669 Activatable Proprotein construct

<400>  212

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Ser Gly Ser Gly Ser Glu Asn Leu Tyr Phe 
    130                 135                 140                 


Gln Gly Gly Ser Gly Ser Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro 
145                 150                 155                 160 


Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr 
                165                 170                 175     


Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly 
            180                 185                 190         


Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp 
        195                 200                 205             


Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln 
    210                 215                 220                 


Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met 
225                 230                 235                 240 


Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys 
                245                 250                 255     


Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His 
            260                 265                 270         


Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg 
        275                 280                 285             


Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly 
    290                 295                 300                 


Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr 
                325                 330                 335     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            340                 345                 350         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        355                 360                 365             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    370                 375                 380                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
385                 390                 395                 400 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                405                 410                 415     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            420                 425                 430         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        435                 440                 445             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    450                 455                 460                 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
465                 470                 475                 480 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                485                 490                 495     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            500                 505                 510         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        515                 520                 525             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    530                 535                 540                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555                 560 


<210>  213
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1719 Activatable Proprotein construct

<400>  213

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Cys Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp 
    130                 135                 140                 


Asn Gln Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His 
145                 150                 155                 160 


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
                165                 170                 175     


Glu Cys Lys Arg Gly Phe Arg Arg Ile Cys Ser Gly Ser Leu Tyr Met 
            180                 185                 190         


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
        195                 200                 205             


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
    210                 215                 220                 


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
225                 230                 235                 240 


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
                245                 250                 255     


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
            260                 265                 270         


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
        275                 280                 285             


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
    290                 295                 300                 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser His 
305                 310                 315                 320 


His His His His His 
                325 


<210>  214
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1719 cleaved protein construct

<400>  214

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Cys Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Pro Leu Gly Leu Ala Gly Ser Gly Arg 
    130                 135                 140         


<210>  215
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1719 cleaved protein construct

<400>  215

Ser Asp Asn Gln Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
1               5                   10                  15      


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
            20                  25                  30          


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Cys Ser Gly Ser Leu 
        35                  40                  45              


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
    50                  55                  60                  


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
65                  70                  75                  80  


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
                85                  90                  95      


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
            100                 105                 110         


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
        115                 120                 125             


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
    130                 135                 140                 


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
145                 150                 155                 160 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly 
                165                 170                 175     


Ser His His His His His His 
            180             


<210>  216
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1719 cleaved protein construct

<400>  216

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Cys Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp 
    130                 135                 140                 


Asn Gln Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His 
145                 150                 155                 160 


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
                165                 170                 175     


Glu Cys Lys Arg Gly Phe Arg Arg Ile Cys Ser Gly Ser Leu Tyr Met 
            180                 185                 190         


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
        195                 200                 205             


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
    210                 215                 220                 


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
225                 230                 235                 240 


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
                245                 250                 255     


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
            260                 265                 270         


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
        275                 280                 285             


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
    290                 295                 300                 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser His 
305                 310                 315                 320 


His His His His His 
                325 


<210>  217
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1719 cleaved protein construct

<400>  217

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Cys Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Pro Leu Gly Leu Ala Gly Ser Gly Arg 
    130                 135                 140         


<210>  218
<211>  183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1719 cleaved protein construct

<400>  218

Ser Asp Asn Gln Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
1               5                   10                  15      


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
            20                  25                  30          


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Cys Ser Gly Ser Leu 
        35                  40                  45              


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
    50                  55                  60                  


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
65                  70                  75                  80  


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
                85                  90                  95      


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
            100                 105                 110         


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
        115                 120                 125             


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
    130                 135                 140                 


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
145                 150                 155                 160 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly 
                165                 170                 175     


Ser His His His His His His 
            180             


<210>  219
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1719 cleaved protein construct

<400>  219

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Cys Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Pro Leu Gly 
    130                 135     


<210>  220
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1719 cleaved protein construct

<400>  220

Leu Ala Gly Ser Gly Arg Ser Asp Asn Gln Gly Ala Glu Leu Cys Asp 
1               5                   10                  15      


Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr 
            20                  25                  30          


Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg 
        35                  40                  45              


Ile Cys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His 
    50                  55                  60                  


Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn 
65                  70                  75                  80  


Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys 
                85                  90                  95      


Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu 
            100                 105                 110         


Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu 
        115                 120                 125             


Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val 
    130                 135                 140                 


Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys 
145                 150                 155                 160 


Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr 
                165                 170                 175     


Gly Glu Gly Gly Gly Gly Ser His His His His His His 
            180                 185                 


<210>  221
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1719 cleaved protein construct

<400>  221

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Cys Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp 
    130                 135                 140                 


Asn Gln Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His 
145                 150                 155                 160 


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
                165                 170                 175     


Glu Cys Lys Arg Gly Phe Arg Arg Ile Cys Ser Gly Ser Leu Tyr Met 
            180                 185                 190         


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
        195                 200                 205             


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
    210                 215                 220                 


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
225                 230                 235                 240 


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
                245                 250                 255     


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
            260                 265                 270         


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
        275                 280                 285             


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
    290                 295                 300                 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser His 
305                 310                 315                 320 


His His His His His 
                325 


<210>  222
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1719 cleaved protein construct

<400>  222

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Cys Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Pro Leu Gly 
    130                 135     


<210>  223
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1719 cleaved protein construct

<400>  223

Leu Ala Gly Ser Gly Arg Ser Asp Asn Gln Gly Ala Glu Leu Cys Asp 
1               5                   10                  15      


Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr 
            20                  25                  30          


Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg 
        35                  40                  45              


Ile Cys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His 
    50                  55                  60                  


Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn 
65                  70                  75                  80  


Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys 
                85                  90                  95      


Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu 
            100                 105                 110         


Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu 
        115                 120                 125             


Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val 
    130                 135                 140                 


Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys 
145                 150                 155                 160 


Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr 
                165                 170                 175     


Gly Glu Gly Gly Gly Gly Ser His His His His His His 
            180                 185                 


<210>  224
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1719 cleaved protein construct

<400>  224

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Cys Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp 
    130                 135                 140                 


Asn 
145 


<210>  225
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1719 cleaved protein construct

<400>  225

Gln Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala 
1               5                   10                  15      


Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu 
            20                  25                  30          


Cys Lys Arg Gly Phe Arg Arg Ile Cys Ser Gly Ser Leu Tyr Met Leu 
        35                  40                  45              


Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys 
    50                  55                  60                  


Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro 
65                  70                  75                  80  


Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln 
                85                  90                  95      


Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro 
            100                 105                 110         


Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln 
        115                 120                 125             


Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly 
    130                 135                 140                 


Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr 
145                 150                 155                 160 


Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser His His 
                165                 170                 175     


His His His His 
            180 


<210>  226
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1719 cleaved protein construct

<400>  226

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Cys Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp 
    130                 135                 140                 


Asn Gln Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His 
145                 150                 155                 160 


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
                165                 170                 175     


Glu Cys Lys Arg Gly Phe Arg Arg Ile Cys Ser Gly Ser Leu Tyr Met 
            180                 185                 190         


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
        195                 200                 205             


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
    210                 215                 220                 


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
225                 230                 235                 240 


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
                245                 250                 255     


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
            260                 265                 270         


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
        275                 280                 285             


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
    290                 295                 300                 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser His 
305                 310                 315                 320 


His His His His His 
                325 


<210>  227
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1719 cleaved protein construct

<400>  227

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Cys Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp 
    130                 135                 140                 


Asn 
145 


<210>  228
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1719 cleaved protein construct

<400>  228

Gln Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala 
1               5                   10                  15      


Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu 
            20                  25                  30          


Cys Lys Arg Gly Phe Arg Arg Ile Cys Ser Gly Ser Leu Tyr Met Leu 
        35                  40                  45              


Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys 
    50                  55                  60                  


Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro 
65                  70                  75                  80  


Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln 
                85                  90                  95      


Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro 
            100                 105                 110         


Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln 
        115                 120                 125             


Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly 
    130                 135                 140                 


Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr 
145                 150                 155                 160 


Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser His His 
                165                 170                 175     


His His His His 
            180 


<210>  229
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1720 Activatable Proprotein construct

<400>  229

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
                245                 250                 255     


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            260                 265                 270         


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
        275                 280                 285             


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Cys Glu Leu 
    290                 295                 300                 


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
305                 310                 315                 320 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                325                 330                 335     


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            340                 345                 350         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
        355                 360                 365             


Ile Ile Ser Thr Leu Thr Gly Pro Leu Gly Leu Ala Gly Ser Gly Arg 
    370                 375                 380                 


Ser Asp Asn Gln Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
385                 390                 395                 400 


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
                405                 410                 415     


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Cys Ser Gly Ser Leu 
            420                 425                 430         


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
        435                 440                 445             


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
    450                 455                 460                 


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
465                 470                 475                 480 


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
                485                 490                 495     


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
            500                 505                 510         


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
        515                 520                 525             


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
    530                 535                 540                 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555     


<210>  230
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1721 Activatable Proprotein construct

<400>  230

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Cys Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser Asp 
    130                 135                 140                 


Asn Gln Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His 
145                 150                 155                 160 


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
                165                 170                 175     


Glu Cys Lys Arg Gly Phe Arg Arg Ile Cys Ser Gly Ser Leu Tyr Met 
            180                 185                 190         


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
        195                 200                 205             


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
    210                 215                 220                 


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
225                 230                 235                 240 


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
                245                 250                 255     


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
            260                 265                 270         


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
        275                 280                 285             


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
    290                 295                 300                 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
                325                 330                 335     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            340                 345                 350         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        355                 360                 365             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    370                 375                 380                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
385                 390                 395                 400 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                405                 410                 415     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            420                 425                 430         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        435                 440                 445             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    450                 455                 460                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
465                 470                 475                 480 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                485                 490                 495     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            500                 505                 510         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        515                 520                 525             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    530                 535                 540                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555     


<210>  231
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1722 Activatable Proprotein construct

<400>  231

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Cys Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser 
    130                 135                 140                 


Asp Asn Gln Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
145                 150                 155                 160 


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
                165                 170                 175     


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Cys Ser Gly Ser Leu Tyr 
            180                 185                 190         


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
        195                 200                 205             


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
    210                 215                 220                 


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
225                 230                 235                 240 


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
                245                 250                 255     


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
            260                 265                 270         


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
        275                 280                 285             


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
    290                 295                 300                 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser 
305                 310                 315                 320 


His His His His His His 
                325     


<210>  232
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1723 Activatable Proprotein construct

<400>  232

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
                245                 250                 255     


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            260                 265                 270         


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
        275                 280                 285             


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Cys Glu Leu 
    290                 295                 300                 


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
305                 310                 315                 320 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                325                 330                 335     


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            340                 345                 350         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
        355                 360                 365             


Ile Ile Ser Thr Leu Thr Gly Gly Pro Leu Gly Leu Ala Gly Ser Gly 
    370                 375                 380                 


Arg Ser Asp Asn Gln Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu 
385                 390                 395                 400 


Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met 
                405                 410                 415     


Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Cys Ser Gly Ser 
            420                 425                 430         


Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn 
        435                 440                 445             


Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val 
    450                 455                 460                 


Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln 
465                 470                 475                 480 


Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg 
                485                 490                 495     


Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe 
            500                 505                 510         


Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala 
        515                 520                 525             


Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys 
    530                 535                 540                 


Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555         


<210>  233
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1724 Activatable Proprotein construct

<400>  233

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Cys Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Pro Leu Gly Leu Ala Gly Ser Gly Arg Ser 
    130                 135                 140                 


Asp Asn Gln Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
145                 150                 155                 160 


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
                165                 170                 175     


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Cys Ser Gly Ser Leu Tyr 
            180                 185                 190         


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
        195                 200                 205             


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
    210                 215                 220                 


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
225                 230                 235                 240 


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
                245                 250                 255     


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
            260                 265                 270         


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
        275                 280                 285             


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
    290                 295                 300                 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
                325                 330                 335     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            340                 345                 350         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        355                 360                 365             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    370                 375                 380                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
385                 390                 395                 400 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                405                 410                 415     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            420                 425                 430         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        435                 440                 445             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    450                 455                 460                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
465                 470                 475                 480 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                485                 490                 495     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            500                 505                 510         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        515                 520                 525             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    530                 535                 540                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555         


<210>  234
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1725 Activatable Proprotein construct

<400>  234

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe 
                245                 250                 255     


Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys 
            260                 265                 270         


Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr 
        275                 280                 285             


Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser 
    290                 295                 300                 


Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu 
305                 310                 315                 320 


Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val 
                325                 330                 335     


Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu 
            340                 345                 350         


Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val 
        355                 360                 365             


Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala 
    370                 375                 380                 


Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro 
385                 390                 395                 400 


Gln Leu Ile Cys Thr Gly Glu Pro Leu Gly Leu Ala Gly Ser Gly Arg 
                405                 410                 415     


Ser Asp Asn Gln Gly Ala Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr 
            420                 425                 430         


Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn 
        435                 440                 445             


Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe 
    450                 455                 460                 


Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys 
465                 470                 475                 480 


Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln 
                485                 490                 495     


Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
            500                 505                 510         


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
        515                 520                 525             


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
    530                 535                 540                 


Thr Phe Ser Gln Ser Ile Ile Ser Thr Leu Thr 
545                 550                 555 


<210>  235
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1726 Activatable Proprotein construct

<400>  235

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe 
                245                 250                 255     


Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys 
            260                 265                 270         


Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr 
        275                 280                 285             


Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser 
    290                 295                 300                 


Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu 
305                 310                 315                 320 


Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val 
                325                 330                 335     


Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu 
            340                 345                 350         


Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val 
        355                 360                 365             


Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala 
    370                 375                 380                 


Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro 
385                 390                 395                 400 


Gln Leu Ile Cys Thr Gly Glu Pro Leu Gly Leu Ala Gly Ser Gly Arg 
                405                 410                 415     


Ser Asp Asn Gln Gly Ala Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr 
            420                 425                 430         


Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn 
        435                 440                 445             


Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe 
    450                 455                 460                 


Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys 
465                 470                 475                 480 


Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln 
                485                 490                 495     


Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
            500                 505                 510         


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
        515                 520                 525             


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
    530                 535                 540                 


Thr Phe Ser Gln Ser Ile Ile Ser Thr Leu Thr 
545                 550                 555 


<210>  236
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1727 Activatable Proprotein construct

<400>  236

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Glu Leu Cys Cys Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe 
                245                 250                 255     


Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys 
            260                 265                 270         


Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr 
        275                 280                 285             


Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser 
    290                 295                 300                 


Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu 
305                 310                 315                 320 


Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val 
                325                 330                 335     


Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu 
            340                 345                 350         


Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val 
        355                 360                 365             


Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala 
    370                 375                 380                 


Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro 
385                 390                 395                 400 


Gln Leu Ile Cys Thr Gly Glu Pro Leu Gly Leu Ala Gly Ser Gly Arg 
                405                 410                 415     


Ser Asp Asn Gln Gly Ala Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr 
            420                 425                 430         


Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn 
        435                 440                 445             


Gly Ile Asn Asn Tyr Lys Asn Pro Cys Leu Thr Arg Met Leu Thr Phe 
    450                 455                 460                 


Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys 
465                 470                 475                 480 


Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln 
                485                 490                 495     


Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
            500                 505                 510         


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
        515                 520                 525             


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
    530                 535                 540                 


Thr Phe Ser Gln Ser Ile Ile Ser Thr Leu Thr 
545                 550                 555 


<210>  237
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1728 Activatable Proprotein construct

<400>  237

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe 
                245                 250                 255     


Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys 
            260                 265                 270         


Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr 
        275                 280                 285             


Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser 
    290                 295                 300                 


Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu 
305                 310                 315                 320 


Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val 
                325                 330                 335     


Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu 
            340                 345                 350         


Asn Glu Ala Thr Glu Arg Ile Tyr Cys Phe Val Val Gly Gln Met Val 
        355                 360                 365             


Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala 
    370                 375                 380                 


Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro 
385                 390                 395                 400 


Gln Leu Ile Cys Thr Gly Glu Pro Leu Gly Leu Ala Gly Ser Gly Arg 
                405                 410                 415     


Ser Asp Asn Gln Gly Ala Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr 
            420                 425                 430         


Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn 
        435                 440                 445             


Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Cys Met Leu Thr Phe 
    450                 455                 460                 


Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys 
465                 470                 475                 480 


Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln 
                485                 490                 495     


Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
            500                 505                 510         


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
        515                 520                 525             


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
    530                 535                 540                 


Thr Phe Ser Gln Ser Ile Ile Ser Thr Leu Thr 
545                 550                 555 


<210>  238
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1729 Activatable Proprotein construct

<400>  238

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe 
                245                 250                 255     


Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys 
            260                 265                 270         


Arg Gly Phe Arg Arg Ile Cys Ser Gly Ser Leu Tyr Met Leu Cys Thr 
        275                 280                 285             


Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser 
    290                 295                 300                 


Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu 
305                 310                 315                 320 


Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val 
                325                 330                 335     


Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu 
            340                 345                 350         


Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val 
        355                 360                 365             


Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala 
    370                 375                 380                 


Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro 
385                 390                 395                 400 


Gln Leu Ile Cys Thr Gly Glu Pro Leu Gly Leu Ala Gly Ser Gly Arg 
                405                 410                 415     


Ser Asp Asn Gln Gly Ala Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr 
            420                 425                 430         


Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn 
        435                 440                 445             


Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe 
    450                 455                 460                 


Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys 
465                 470                 475                 480 


Leu Glu Cys Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln 
                485                 490                 495     


Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
            500                 505                 510         


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
        515                 520                 525             


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
    530                 535                 540                 


Thr Phe Ser Gln Ser Ile Ile Ser Thr Leu Thr 
545                 550                 555 


<210>  239
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1730 Activatable Proprotein construct

<400>  239

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe 
                245                 250                 255     


Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys 
            260                 265                 270         


Arg Gly Phe Arg Arg Ile Lys Cys Gly Ser Leu Tyr Met Leu Cys Thr 
        275                 280                 285             


Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser 
    290                 295                 300                 


Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu 
305                 310                 315                 320 


Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val 
                325                 330                 335     


Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu 
            340                 345                 350         


Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val 
        355                 360                 365             


Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala 
    370                 375                 380                 


Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro 
385                 390                 395                 400 


Gln Leu Ile Cys Thr Gly Glu Pro Leu Gly Leu Ala Gly Ser Gly Arg 
                405                 410                 415     


Ser Asp Asn Gln Gly Ala Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr 
            420                 425                 430         


Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn 
        435                 440                 445             


Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe 
    450                 455                 460                 


Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys 
465                 470                 475                 480 


Leu Glu Cys Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln 
                485                 490                 495     


Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
            500                 505                 510         


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
        515                 520                 525             


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
    530                 535                 540                 


Thr Phe Ser Gln Ser Ile Ile Ser Thr Leu Thr 
545                 550                 555 


<210>  240
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1773 Activatable Proprotein construct

<400>  240

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Gly Ser Gly Ser Glu Asn Leu Tyr Phe Gln 
                165                 170                 175     


Gly Gly Ser Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
            180                 185                 190         


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
        195                 200                 205             


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
    210                 215                 220                 


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
225                 230                 235                 240 


Glu Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser 
                245                 250                 255     


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
            260                 265                 270         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
        275                 280                 285             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    290                 295                 300                 


Phe Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser His 
305                 310                 315                 320 


His His His His His 
                325 


<210>  241
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1774 Activatable Proprotein construct

<400>  241

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr 
                245                 250                 255     


Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys 
            260                 265                 270         


Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys 
        275                 280                 285             


Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr 
    290                 295                 300                 


Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu 
305                 310                 315                 320 


Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro 
                325                 330                 335     


Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp 
            340                 345                 350         


Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met 
        355                 360                 365             


Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro 
    370                 375                 380                 


Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln 
385                 390                 395                 400 


Pro Gln Leu Ile Cys Thr Gly Glu Gly Ser Gly Ser Glu Asn Leu Tyr 
                405                 410                 415     


Phe Gln Gly Gly Ser Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys 
            420                 425                 430         


Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu 
        435                 440                 445             


Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr 
    450                 455                 460                 


Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln 
465                 470                 475                 480 


Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala 
                485                 490                 495     


Pro Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile 
            500                 505                 510         


Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys 
        515                 520                 525             


Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp 
    530                 535                 540                 


Ile Thr Phe Ser Gln Ser Thr Ile Ser Thr Leu Thr 
545                 550                 555     


<210>  242
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1775 Activatable Proprotein construct

<400>  242

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Gly Ser Gly Ser Glu Asn Leu Tyr Phe Gln 
                165                 170                 175     


Gly Gly Ser Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln 
            180                 185                 190         


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
        195                 200                 205             


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
    210                 215                 220                 


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
225                 230                 235                 240 


Glu Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser 
                245                 250                 255     


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
            260                 265                 270         


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
        275                 280                 285             


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
    290                 295                 300                 


Phe Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
                325                 330                 335     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            340                 345                 350         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        355                 360                 365             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    370                 375                 380                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
385                 390                 395                 400 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                405                 410                 415     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            420                 425                 430         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        435                 440                 445             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    450                 455                 460                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
465                 470                 475                 480 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                485                 490                 495     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            500                 505                 510         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        515                 520                 525             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    530                 535                 540                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555     


<210>  243
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1776 Activatable Proprotein construct

<400>  243

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Gly Ser Gly Ser Gly Ser Glu Asn Leu Tyr 
                165                 170                 175     


Phe Gln Gly Gly Ser Gly Ser Gly Ser Ala Pro Thr Ser Ser Ser Thr 
            180                 185                 190         


Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met 
        195                 200                 205             


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
    210                 215                 220                 


Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
225                 230                 235                 240 


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn 
                245                 250                 255     


Leu Ala Pro Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
            260                 265                 270         


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
        275                 280                 285             


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
    290                 295                 300                 


Arg Trp Ile Thr Phe Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly 
305                 310                 315                 320 


Gly Gly Ser His His His His His His 
                325                 


<210>  244
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1777 Activatable Proprotein construct

<400>  244

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr 
                245                 250                 255     


Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys 
            260                 265                 270         


Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys 
        275                 280                 285             


Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr 
    290                 295                 300                 


Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu 
305                 310                 315                 320 


Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro 
                325                 330                 335     


Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp 
            340                 345                 350         


Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met 
        355                 360                 365             


Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro 
    370                 375                 380                 


Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln 
385                 390                 395                 400 


Pro Gln Leu Ile Cys Thr Gly Glu Gly Ser Gly Ser Gly Ser Glu Asn 
                405                 410                 415     


Leu Tyr Phe Gln Gly Gly Ser Gly Ser Gly Ser Ala Pro Thr Ser Ser 
            420                 425                 430         


Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu 
        435                 440                 445             


Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr 
    450                 455                 460                 


Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu 
465                 470                 475                 480 


Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Ala 
                485                 490                 495     


Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu 
            500                 505                 510         


Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr 
        515                 520                 525             


Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe 
    530                 535                 540                 


Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr Ile Ser Thr Leu Thr 
545                 550                 555                 560 


<210>  245
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1778 Activatable Proprotein construct

<400>  245

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Gly Ser Gly Ser Gly Ser Glu Asn Leu Tyr 
                165                 170                 175     


Phe Gln Gly Gly Ser Gly Ser Gly Ser Ala Pro Thr Ser Ser Ser Thr 
            180                 185                 190         


Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met 
        195                 200                 205             


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
    210                 215                 220                 


Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
225                 230                 235                 240 


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn 
                245                 250                 255     


Leu Ala Pro Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
            260                 265                 270         


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
        275                 280                 285             


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
    290                 295                 300                 


Arg Trp Ile Thr Phe Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr 
                325                 330                 335     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            340                 345                 350         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        355                 360                 365             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    370                 375                 380                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
385                 390                 395                 400 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                405                 410                 415     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            420                 425                 430         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        435                 440                 445             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    450                 455                 460                 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
465                 470                 475                 480 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                485                 490                 495     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            500                 505                 510         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        515                 520                 525             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    530                 535                 540                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555                 560 


<210>  246
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1779 Activatable Proprotein construct

<400>  246

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly 
    130                 135                 140                 


Arg Ser Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro 
145                 150                 155                 160 


Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr 
                165                 170                 175     


Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly 
            180                 185                 190         


Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp 
        195                 200                 205             


Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln 
    210                 215                 220                 


Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met 
225                 230                 235                 240 


Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys 
                245                 250                 255     


Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His 
            260                 265                 270         


Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg 
        275                 280                 285             


Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly 
    290                 295                 300                 


Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr 
                325                 330                 335     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
            340                 345                 350         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        355                 360                 365             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    370                 375                 380                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
385                 390                 395                 400 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                405                 410                 415     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            420                 425                 430         


Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr 
        435                 440                 445             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    450                 455                 460                 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
465                 470                 475                 480 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                485                 490                 495     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            500                 505                 510         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        515                 520                 525             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    530                 535                 540                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555                 560 


<210>  247
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1779 cleaved protein construct

<400>  247

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly 
    130                 135                 140                 


Arg 
145 


<210>  248
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1779 cleaved protein construct

<400>  248

Ser Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu 
1               5                   10                  15      


Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met 
            20                  25                  30          


Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser 
        35                  40                  45              


Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn 
    50                  55                  60                  


Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val 
65                  70                  75                  80  


Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln 
                85                  90                  95      


Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg 
            100                 105                 110         


Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe 
        115                 120                 125             


Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala 
    130                 135                 140                 


Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys 
145                 150                 155                 160 


Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            180                 185                 190         


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
        195                 200                 205             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    210                 215                 220                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
225                 230                 235                 240 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                245                 250                 255     


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            260                 265                 270         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        275                 280                 285             


Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile 
    290                 295                 300                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
305                 310                 315                 320 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                325                 330                 335     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            340                 345                 350         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        355                 360                 365             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    370                 375                 380                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
385                 390                 395                 400 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410                 415 


<210>  249
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1779 cleaved protein construct

<400>  249

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly 
    130                 135                 140                 


Arg Ser Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro 
145                 150                 155                 160 


Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr 
                165                 170                 175     


Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly 
            180                 185                 190         


Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp 
        195                 200                 205             


Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln 
    210                 215                 220                 


Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met 
225                 230                 235                 240 


Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys 
                245                 250                 255     


Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His 
            260                 265                 270         


Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg 
        275                 280                 285             


Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly 
    290                 295                 300                 


Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr 
                325                 330                 335     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
            340                 345                 350         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        355                 360                 365             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    370                 375                 380                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
385                 390                 395                 400 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                405                 410                 415     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            420                 425                 430         


Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr 
        435                 440                 445             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    450                 455                 460                 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
465                 470                 475                 480 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                485                 490                 495     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            500                 505                 510         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        515                 520                 525             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    530                 535                 540                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555                 560 


<210>  250
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1779 cleaved protein construct

<400>  250

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly 
    130                 135                 140                 


Arg 
145 


<210>  251
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1779 cleaved protein construct

<400>  251

Ser Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu 
1               5                   10                  15      


Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met 
            20                  25                  30          


Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser 
        35                  40                  45              


Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn 
    50                  55                  60                  


Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val 
65                  70                  75                  80  


Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln 
                85                  90                  95      


Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg 
            100                 105                 110         


Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe 
        115                 120                 125             


Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala 
    130                 135                 140                 


Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys 
145                 150                 155                 160 


Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His 
            180                 185                 190         


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
        195                 200                 205             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    210                 215                 220                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
225                 230                 235                 240 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                245                 250                 255     


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            260                 265                 270         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        275                 280                 285             


Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile 
    290                 295                 300                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
305                 310                 315                 320 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                325                 330                 335     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            340                 345                 350         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        355                 360                 365             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    370                 375                 380                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
385                 390                 395                 400 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410                 415 


<210>  252
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1779 cleaved protein construct

<400>  252

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Ser Pro Leu Gly 
    130                 135                 


<210>  253
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1779 cleaved protein construct

<400>  253

Leu Ala Gly Ser Gly Arg Ser Asp Asn His Gly Gly Ala Glu Leu Cys 
1               5                   10                  15      


Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala 
            20                  25                  30          


Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg 
        35                  40                  45              


Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser 
    50                  55                  60                  


His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg 
65                  70                  75                  80  


Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg 
                85                  90                  95      


Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser 
            100                 105                 110         


Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr 
        115                 120                 125             


Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys 
    130                 135                 140                 


Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys 
145                 150                 155                 160 


Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys 
                165                 170                 175     


Thr Gly Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys 
            180                 185                 190         


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
        195                 200                 205             


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    210                 215                 220                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
225                 230                 235                 240 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                245                 250                 255     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            260                 265                 270         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        275                 280                 285             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala 
    290                 295                 300                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
305                 310                 315                 320 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                325                 330                 335     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            340                 345                 350         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        355                 360                 365             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    370                 375                 380                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
385                 390                 395                 400 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                405                 410                 415     


Leu Ser Pro Gly Lys 
            420     


<210>  254
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1779 cleaved protein construct

<400>  254

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly 
    130                 135                 140                 


Arg Ser Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro 
145                 150                 155                 160 


Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr 
                165                 170                 175     


Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly 
            180                 185                 190         


Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp 
        195                 200                 205             


Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln 
    210                 215                 220                 


Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met 
225                 230                 235                 240 


Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys 
                245                 250                 255     


Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His 
            260                 265                 270         


Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg 
        275                 280                 285             


Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly 
    290                 295                 300                 


Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr 
                325                 330                 335     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
            340                 345                 350         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        355                 360                 365             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    370                 375                 380                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
385                 390                 395                 400 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                405                 410                 415     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            420                 425                 430         


Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr 
        435                 440                 445             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    450                 455                 460                 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
465                 470                 475                 480 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                485                 490                 495     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            500                 505                 510         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        515                 520                 525             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    530                 535                 540                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555                 560 


<210>  255
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1779 cleaved protein construct

<400>  255

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Ser Pro Leu Gly 
    130                 135                 


<210>  256
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1779 cleaved protein construct

<400>  256

Leu Ala Gly Ser Gly Arg Ser Asp Asn His Gly Gly Ala Glu Leu Cys 
1               5                   10                  15      


Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala 
            20                  25                  30          


Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg 
        35                  40                  45              


Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser 
    50                  55                  60                  


His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg 
65                  70                  75                  80  


Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg 
                85                  90                  95      


Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser 
            100                 105                 110         


Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr 
        115                 120                 125             


Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys 
    130                 135                 140                 


Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys 
145                 150                 155                 160 


Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys 
                165                 170                 175     


Thr Gly Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys 
            180                 185                 190         


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
        195                 200                 205             


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
    210                 215                 220                 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
225                 230                 235                 240 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
                245                 250                 255     


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
            260                 265                 270         


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
        275                 280                 285             


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala 
    290                 295                 300                 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
305                 310                 315                 320 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
                325                 330                 335     


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
            340                 345                 350         


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
        355                 360                 365             


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
    370                 375                 380                 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
385                 390                 395                 400 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
                405                 410                 415     


Leu Ser Pro Gly Lys 
            420     


<210>  257
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1779 cleaved protein construct

<400>  257

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly 
    130                 135                 140                 


Arg Ser Asp Asn 
145             


<210>  258
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1779 cleaved protein construct

<400>  258

His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His 
1               5                   10                  15      


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
            20                  25                  30          


Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met 
        35                  40                  45              


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
    50                  55                  60                  


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
65                  70                  75                  80  


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
                85                  90                  95      


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
            100                 105                 110         


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
        115                 120                 125             


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
    130                 135                 140                 


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
145                 150                 155                 160 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
            180                 185                 190         


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
        195                 200                 205             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    210                 215                 220                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
225                 230                 235                 240 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                245                 250                 255     


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            260                 265                 270         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        275                 280                 285             


Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    290                 295                 300                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
305                 310                 315                 320 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                325                 330                 335     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            340                 345                 350         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        355                 360                 365             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    370                 375                 380                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
385                 390                 395                 400 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410         


<210>  259
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1779 cleaved protein construct

<400>  259

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly 
    130                 135                 140                 


Arg Ser Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro 
145                 150                 155                 160 


Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr 
                165                 170                 175     


Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly 
            180                 185                 190         


Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp 
        195                 200                 205             


Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln 
    210                 215                 220                 


Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met 
225                 230                 235                 240 


Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys 
                245                 250                 255     


Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His 
            260                 265                 270         


Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg 
        275                 280                 285             


Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly 
    290                 295                 300                 


Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr 
                325                 330                 335     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
            340                 345                 350         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        355                 360                 365             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    370                 375                 380                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
385                 390                 395                 400 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                405                 410                 415     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            420                 425                 430         


Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr 
        435                 440                 445             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    450                 455                 460                 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
465                 470                 475                 480 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                485                 490                 495     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            500                 505                 510         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        515                 520                 525             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    530                 535                 540                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555                 560 


<210>  260
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1779 cleaved protein construct

<400>  260

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly 
    130                 135                 140                 


Arg Ser Asp Asn 
145             


<210>  261
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1779 cleaved protein construct

<400>  261

His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His 
1               5                   10                  15      


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
            20                  25                  30          


Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met 
        35                  40                  45              


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
    50                  55                  60                  


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
65                  70                  75                  80  


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
                85                  90                  95      


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
            100                 105                 110         


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
        115                 120                 125             


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
    130                 135                 140                 


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
145                 150                 155                 160 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
            180                 185                 190         


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
        195                 200                 205             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    210                 215                 220                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
225                 230                 235                 240 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                245                 250                 255     


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            260                 265                 270         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        275                 280                 285             


Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    290                 295                 300                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
305                 310                 315                 320 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                325                 330                 335     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            340                 345                 350         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        355                 360                 365             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    370                 375                 380                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
385                 390                 395                 400 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                405                 410         


<210>  262
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1780 Activatable Proprotein construct

<400>  262

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly 
    130                 135                 140                 


Arg Ser Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro 
145                 150                 155                 160 


Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr 
                165                 170                 175     


Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly 
            180                 185                 190         


Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp 
        195                 200                 205             


Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln 
    210                 215                 220                 


Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met 
225                 230                 235                 240 


Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys 
                245                 250                 255     


Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His 
            260                 265                 270         


Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg 
        275                 280                 285             


Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly 
    290                 295                 300                 


Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
                325                 330                 335     


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
            340                 345                 350         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        355                 360                 365             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    370                 375                 380                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
385                 390                 395                 400 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                405                 410                 415     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            420                 425                 430         


Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser 
        435                 440                 445             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    450                 455                 460                 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
465                 470                 475                 480 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                485                 490                 495     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            500                 505                 510         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        515                 520                 525             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    530                 535                 540                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555             


<210>  263
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1781 Activatable Proprotein construct

<400>  263

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly 
    130                 135                 140                 


Arg Ser Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro 
145                 150                 155                 160 


Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr 
                165                 170                 175     


Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly 
            180                 185                 190         


Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp 
        195                 200                 205             


Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln 
    210                 215                 220                 


Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met 
225                 230                 235                 240 


Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys 
                245                 250                 255     


Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His 
            260                 265                 270         


Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg 
        275                 280                 285             


Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly 
    290                 295                 300                 


Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Ser Gly 
305                 310                 315                 320 


Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
                325                 330                 335     


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
            340                 345                 350         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        355                 360                 365             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    370                 375                 380                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
385                 390                 395                 400 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                405                 410                 415     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            420                 425                 430         


Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        435                 440                 445             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    450                 455                 460                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
465                 470                 475                 480 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                485                 490                 495     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            500                 505                 510         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        515                 520                 525             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    530                 535                 540                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555     


<210>  264
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1782 Activatable Proprotein construct

<400>  264

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly 
    130                 135                 140                 


Arg Ser Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro 
145                 150                 155                 160 


Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr 
                165                 170                 175     


Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly 
            180                 185                 190         


Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp 
        195                 200                 205             


Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln 
    210                 215                 220                 


Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met 
225                 230                 235                 240 


Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys 
                245                 250                 255     


Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His 
            260                 265                 270         


Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg 
        275                 280                 285             


Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly 
    290                 295                 300                 


Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly 
305                 310                 315                 320 


Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
                325                 330                 335     


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            340                 345                 350         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        355                 360                 365             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    370                 375                 380                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
385                 390                 395                 400 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                405                 410                 415     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            420                 425                 430         


Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        435                 440                 445             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    450                 455                 460                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
465                 470                 475                 480 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                485                 490                 495     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            500                 505                 510         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        515                 520                 525             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    530                 535                 540                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 


<210>  265
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1783 Activatable Proprotein construct

<400>  265

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly 
    130                 135                 140                 


Arg Ser Asp Asn Gln Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro 
145                 150                 155                 160 


Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr 
                165                 170                 175     


Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly 
            180                 185                 190         


Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp 
        195                 200                 205             


Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln 
    210                 215                 220                 


Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met 
225                 230                 235                 240 


Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys 
                245                 250                 255     


Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His 
            260                 265                 270         


Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg 
        275                 280                 285             


Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly 
    290                 295                 300                 


Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr 
                325                 330                 335     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
            340                 345                 350         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        355                 360                 365             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    370                 375                 380                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
385                 390                 395                 400 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                405                 410                 415     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            420                 425                 430         


Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr 
        435                 440                 445             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    450                 455                 460                 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
465                 470                 475                 480 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                485                 490                 495     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            500                 505                 510         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        515                 520                 525             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    530                 535                 540                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555                 560 


<210>  266
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1784 Activatable Proprotein construct

<400>  266

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly 
    130                 135                 140                 


Arg Ser Asp Asn Arg Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro 
145                 150                 155                 160 


Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr 
                165                 170                 175     


Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly 
            180                 185                 190         


Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp 
        195                 200                 205             


Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln 
    210                 215                 220                 


Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met 
225                 230                 235                 240 


Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys 
                245                 250                 255     


Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His 
            260                 265                 270         


Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg 
        275                 280                 285             


Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly 
    290                 295                 300                 


Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr 
                325                 330                 335     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
            340                 345                 350         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        355                 360                 365             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    370                 375                 380                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
385                 390                 395                 400 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                405                 410                 415     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            420                 425                 430         


Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr 
        435                 440                 445             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    450                 455                 460                 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
465                 470                 475                 480 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                485                 490                 495     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            500                 505                 510         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        515                 520                 525             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    530                 535                 540                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555                 560 


<210>  267
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1785 Activatable Proprotein construct

<400>  267

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser Gly 
    130                 135                 140                 


Arg Ser Asp Asn Thr Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro 
145                 150                 155                 160 


Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr 
                165                 170                 175     


Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly 
            180                 185                 190         


Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp 
        195                 200                 205             


Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln 
    210                 215                 220                 


Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met 
225                 230                 235                 240 


Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys 
                245                 250                 255     


Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His 
            260                 265                 270         


Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg 
        275                 280                 285             


Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly 
    290                 295                 300                 


Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr 
                325                 330                 335     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
            340                 345                 350         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        355                 360                 365             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    370                 375                 380                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
385                 390                 395                 400 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                405                 410                 415     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            420                 425                 430         


Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr 
        435                 440                 445             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    450                 455                 460                 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
465                 470                 475                 480 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                485                 490                 495     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            500                 505                 510         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        515                 520                 525             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    530                 535                 540                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555                 560 


<210>  268
<211>  560
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1786 Activatable Proprotein construct

<400>  268

Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro 
145                 150                 155                 160 


Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr 
                165                 170                 175     


Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly 
            180                 185                 190         


Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp 
        195                 200                 205             


Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln 
    210                 215                 220                 


Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met 
225                 230                 235                 240 


Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys 
                245                 250                 255     


Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His 
            260                 265                 270         


Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg 
        275                 280                 285             


Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly 
    290                 295                 300                 


Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr 
                325                 330                 335     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
            340                 345                 350         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        355                 360                 365             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    370                 375                 380                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
385                 390                 395                 400 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                405                 410                 415     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            420                 425                 430         


Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr 
        435                 440                 445             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    450                 455                 460                 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
465                 470                 475                 480 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                485                 490                 495     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            500                 505                 510         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        515                 520                 525             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    530                 535                 540                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
545                 550                 555                 560 


<210>  269
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 Activatable Proprotein construct

<400>  269

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser 
225                 230                 235                 240 


Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        355                 360                 365             


Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser Asp Asn His Gly 
    370                 375                 380                 


Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr 
385                 390                 395                 400 


Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys 
                405                 410                 415     


Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys 
            420                 425                 430         


Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr 
        435                 440                 445             


Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu 
    450                 455                 460                 


Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro 
465                 470                 475                 480 


Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp 
                485                 490                 495     


Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met 
            500                 505                 510         


Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro 
        515                 520                 525             


Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln 
    530                 535                 540                 


Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550         


<210>  270
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  270

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser 
225                 230                 235                 240 


Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        355                 360                 365             


Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg 
    370                 375                 


<210>  271
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  271

Ser Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu 
1               5                   10                  15      


Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met 
            20                  25                  30          


Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser 
        35                  40                  45              


Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn 
    50                  55                  60                  


Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val 
65                  70                  75                  80  


Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln 
                85                  90                  95      


Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg 
            100                 105                 110         


Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe 
        115                 120                 125             


Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala 
    130                 135                 140                 


Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys 
145                 150                 155                 160 


Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170             


<210>  272
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  272

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser 
225                 230                 235                 240 


Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        355                 360                 365             


Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser Asp Asn His Gly 
    370                 375                 380                 


Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr 
385                 390                 395                 400 


Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys 
                405                 410                 415     


Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys 
            420                 425                 430         


Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr 
        435                 440                 445             


Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu 
    450                 455                 460                 


Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro 
465                 470                 475                 480 


Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp 
                485                 490                 495     


Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met 
            500                 505                 510         


Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro 
        515                 520                 525             


Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln 
    530                 535                 540                 


Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550         


<210>  273
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  273

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser 
225                 230                 235                 240 


Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        355                 360                 365             


Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg 
    370                 375                 


<210>  274
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  274

Ser Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu 
1               5                   10                  15      


Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met 
            20                  25                  30          


Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser 
        35                  40                  45              


Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn 
    50                  55                  60                  


Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val 
65                  70                  75                  80  


Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln 
                85                  90                  95      


Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg 
            100                 105                 110         


Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe 
        115                 120                 125             


Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala 
    130                 135                 140                 


Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys 
145                 150                 155                 160 


Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170             


<210>  275
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  275

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly 
225                 230                 235     


<210>  276
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  276

Leu Ala Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser 
    130                 135                 140                 


Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
145                 150                 155                 160 


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
                165                 170                 175     


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu 
            180                 185                 190         


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
        195                 200                 205             


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
    210                 215                 220                 


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
225                 230                 235                 240 


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
                245                 250                 255     


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
            260                 265                 270         


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
        275                 280                 285             


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
    290                 295                 300                 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
305                 310                 315     


<210>  277
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  277

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser 
225                 230                 235                 240 


Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        355                 360                 365             


Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser Asp Asn His Gly 
    370                 375                 380                 


Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr 
385                 390                 395                 400 


Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys 
                405                 410                 415     


Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys 
            420                 425                 430         


Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr 
        435                 440                 445             


Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu 
    450                 455                 460                 


Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro 
465                 470                 475                 480 


Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp 
                485                 490                 495     


Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met 
            500                 505                 510         


Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro 
        515                 520                 525             


Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln 
    530                 535                 540                 


Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550         


<210>  278
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  278

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly 
225                 230                 235     


<210>  279
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  279

Leu Ala Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser 
    130                 135                 140                 


Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
145                 150                 155                 160 


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
                165                 170                 175     


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu 
            180                 185                 190         


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
        195                 200                 205             


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
    210                 215                 220                 


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
225                 230                 235                 240 


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
                245                 250                 255     


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
            260                 265                 270         


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
        275                 280                 285             


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
    290                 295                 300                 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
305                 310                 315     


<210>  280
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  280

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser 
225                 230                 235                 240 


Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        355                 360                 365             


Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser Asp Asn 
    370                 375                 380         


<210>  281
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  281

His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His 
1               5                   10                  15      


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
            20                  25                  30          


Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met 
        35                  40                  45              


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
    50                  55                  60                  


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
65                  70                  75                  80  


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
                85                  90                  95      


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
            100                 105                 110         


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
        115                 120                 125             


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
    130                 135                 140                 


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
145                 150                 155                 160 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170 


<210>  282
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  282

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser 
225                 230                 235                 240 


Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        355                 360                 365             


Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser Asp Asn His Gly 
    370                 375                 380                 


Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr 
385                 390                 395                 400 


Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys 
                405                 410                 415     


Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys 
            420                 425                 430         


Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr 
        435                 440                 445             


Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu 
    450                 455                 460                 


Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro 
465                 470                 475                 480 


Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp 
                485                 490                 495     


Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met 
            500                 505                 510         


Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro 
        515                 520                 525             


Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln 
    530                 535                 540                 


Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550         


<210>  283
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  283

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser 
225                 230                 235                 240 


Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        355                 360                 365             


Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser Asp Asn 
    370                 375                 380         


<210>  284
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  284

His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His 
1               5                   10                  15      


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
            20                  25                  30          


Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met 
        35                  40                  45              


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
    50                  55                  60                  


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
65                  70                  75                  80  


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
                85                  90                  95      


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
            100                 105                 110         


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
        115                 120                 125             


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
    130                 135                 140                 


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
145                 150                 155                 160 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170 


<210>  285
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  285

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly 
225                 230                 235     


<210>  286
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  286

Leu Ala Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg 
    130                 135                 140             


<210>  287
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  287

Ser Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu 
1               5                   10                  15      


Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met 
            20                  25                  30          


Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser 
        35                  40                  45              


Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn 
    50                  55                  60                  


Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val 
65                  70                  75                  80  


Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln 
                85                  90                  95      


Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg 
            100                 105                 110         


Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe 
        115                 120                 125             


Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala 
    130                 135                 140                 


Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys 
145                 150                 155                 160 


Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170             


<210>  288
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  288

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly 
225                 230                 235     


<210>  289
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  289

Leu Ala Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser 
    130                 135                 140                 


Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
145                 150                 155                 160 


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
                165                 170                 175     


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu 
            180                 185                 190         


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
        195                 200                 205             


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
    210                 215                 220                 


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
225                 230                 235                 240 


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
                245                 250                 255     


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
            260                 265                 270         


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
        275                 280                 285             


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
    290                 295                 300                 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
305                 310                 315     


<210>  290
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  290

Leu Ala Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg 
    130                 135                 140             


<210>  291
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  291

Ser Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu 
1               5                   10                  15      


Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met 
            20                  25                  30          


Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser 
        35                  40                  45              


Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn 
    50                  55                  60                  


Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val 
65                  70                  75                  80  


Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln 
                85                  90                  95      


Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg 
            100                 105                 110         


Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe 
        115                 120                 125             


Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala 
    130                 135                 140                 


Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys 
145                 150                 155                 160 


Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170             


<210>  292
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  292

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser 
225                 230                 235                 240 


Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        355                 360                 365             


Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg 
    370                 375                 


<210>  293
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  293

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly 
225                 230                 235     


<210>  294
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  294

Leu Ala Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg 
    130                 135                 140             


<210>  295
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  295

Ser Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu 
1               5                   10                  15      


Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met 
            20                  25                  30          


Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser 
        35                  40                  45              


Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn 
    50                  55                  60                  


Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val 
65                  70                  75                  80  


Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln 
                85                  90                  95      


Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg 
            100                 105                 110         


Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe 
        115                 120                 125             


Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala 
    130                 135                 140                 


Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys 
145                 150                 155                 160 


Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170             


<210>  296
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  296

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser 
225                 230                 235                 240 


Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        355                 360                 365             


Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser Asp Asn His Gly 
    370                 375                 380                 


Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr 
385                 390                 395                 400 


Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys 
                405                 410                 415     


Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys 
            420                 425                 430         


Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr 
        435                 440                 445             


Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu 
    450                 455                 460                 


Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro 
465                 470                 475                 480 


Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp 
                485                 490                 495     


Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met 
            500                 505                 510         


Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro 
        515                 520                 525             


Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln 
    530                 535                 540                 


Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550         


<210>  297
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  297

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly 
225                 230                 235     


<210>  298
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  298

Leu Ala Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser 
    130                 135                 140                 


Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
145                 150                 155                 160 


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
                165                 170                 175     


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu 
            180                 185                 190         


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
        195                 200                 205             


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
    210                 215                 220                 


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
225                 230                 235                 240 


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
                245                 250                 255     


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
            260                 265                 270         


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
        275                 280                 285             


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
    290                 295                 300                 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
305                 310                 315     


<210>  299
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  299

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser 
225                 230                 235                 240 


Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        355                 360                 365             


Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg 
    370                 375                 


<210>  300
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  300

Ser Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu 
1               5                   10                  15      


Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met 
            20                  25                  30          


Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser 
        35                  40                  45              


Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn 
    50                  55                  60                  


Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val 
65                  70                  75                  80  


Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln 
                85                  90                  95      


Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg 
            100                 105                 110         


Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe 
        115                 120                 125             


Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala 
    130                 135                 140                 


Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys 
145                 150                 155                 160 


Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170             


<210>  301
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  301

Leu Ala Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg 
    130                 135                 140             


<210>  302
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  302

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly 
225                 230                 235     


<210>  303
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  303

Leu Ala Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser 
    130                 135                 140                 


Asp Asn 
145     


<210>  304
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  304

His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His 
1               5                   10                  15      


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
            20                  25                  30          


Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met 
        35                  40                  45              


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
    50                  55                  60                  


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
65                  70                  75                  80  


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
                85                  90                  95      


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
            100                 105                 110         


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
        115                 120                 125             


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
    130                 135                 140                 


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
145                 150                 155                 160 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170 


<210>  305
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  305

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly 
225                 230                 235     


<210>  306
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  306

Leu Ala Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser 
    130                 135                 140                 


Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
145                 150                 155                 160 


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
                165                 170                 175     


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu 
            180                 185                 190         


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
        195                 200                 205             


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
    210                 215                 220                 


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
225                 230                 235                 240 


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
                245                 250                 255     


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
            260                 265                 270         


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
        275                 280                 285             


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
    290                 295                 300                 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
305                 310                 315     


<210>  307
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  307

Leu Ala Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser 
    130                 135                 140                 


Asp Asn 
145     


<210>  308
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  308

His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His 
1               5                   10                  15      


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
            20                  25                  30          


Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met 
        35                  40                  45              


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
    50                  55                  60                  


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
65                  70                  75                  80  


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
                85                  90                  95      


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
            100                 105                 110         


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
        115                 120                 125             


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
    130                 135                 140                 


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
145                 150                 155                 160 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170 


<210>  309
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  309

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser 
225                 230                 235                 240 


Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        355                 360                 365             


Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser Asp Asn 
    370                 375                 380         


<210>  310
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  310

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly 
225                 230                 235     


<210>  311
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  311

Leu Ala Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser 
    130                 135                 140                 


Asp Asn 
145     


<210>  312
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  312

His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His 
1               5                   10                  15      


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
            20                  25                  30          


Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met 
        35                  40                  45              


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
    50                  55                  60                  


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
65                  70                  75                  80  


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
                85                  90                  95      


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
            100                 105                 110         


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
        115                 120                 125             


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
    130                 135                 140                 


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
145                 150                 155                 160 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170 


<210>  313
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  313

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser 
225                 230                 235                 240 


Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        355                 360                 365             


Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser Asp Asn His Gly 
    370                 375                 380                 


Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr 
385                 390                 395                 400 


Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys 
                405                 410                 415     


Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys 
            420                 425                 430         


Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr 
        435                 440                 445             


Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu 
    450                 455                 460                 


Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro 
465                 470                 475                 480 


Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp 
                485                 490                 495     


Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met 
            500                 505                 510         


Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro 
        515                 520                 525             


Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln 
    530                 535                 540                 


Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550         


<210>  314
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  314

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly 
225                 230                 235     


<210>  315
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  315

Leu Ala Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser 
    130                 135                 140                 


Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
145                 150                 155                 160 


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
                165                 170                 175     


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu 
            180                 185                 190         


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
        195                 200                 205             


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
    210                 215                 220                 


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
225                 230                 235                 240 


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
                245                 250                 255     


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
            260                 265                 270         


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
        275                 280                 285             


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
    290                 295                 300                 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
305                 310                 315     


<210>  316
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  316

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly Leu Ala Gly Ser 
225                 230                 235                 240 


Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        355                 360                 365             


Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser Asp Asn 
    370                 375                 380         


<210>  317
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  317

His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His 
1               5                   10                  15      


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
            20                  25                  30          


Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met 
        35                  40                  45              


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
    50                  55                  60                  


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
65                  70                  75                  80  


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
                85                  90                  95      


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
            100                 105                 110         


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
        115                 120                 125             


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
    130                 135                 140                 


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
145                 150                 155                 160 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170 


<210>  318
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1834 cleaved protein construct

<400>  318

Leu Ala Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser 
    130                 135                 140                 


Asp Asn 
145     


<210>  319
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1835 Activatable Proprotein construct

<400>  319

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly Leu Ala Gly Gly 
225                 230                 235                 240 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
                245                 250                 255     


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            260                 265                 270         


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
        275                 280                 285             


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    290                 295                 300                 


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
305                 310                 315                 320 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                325                 330                 335     


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            340                 345                 350         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
        355                 360                 365             


Thr Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser Asp Asn His 
    370                 375                 380                 


Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala 
385                 390                 395                 400 


Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu 
                405                 410                 415     


Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu 
            420                 425                 430         


Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys 
        435                 440                 445             


Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro 
    450                 455                 460                 


Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln 
465                 470                 475                 480 


Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro 
                485                 490                 495     


Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln 
            500                 505                 510         


Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly 
        515                 520                 525             


Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr 
    530                 535                 540                 


Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550             


<210>  320
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1836 Activatable Proprotein construct

<400>  320

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Pro Leu Gly Leu Ala Gly 
225                 230                 235                 240 


Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
                245                 250                 255     


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
            260                 265                 270         


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
        275                 280                 285             


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
    290                 295                 300                 


Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe 
305                 310                 315                 320 


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
                325                 330                 335     


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
            340                 345                 350         


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln 
        355                 360                 365             


Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser Asp Asn 
    370                 375                 380                 


His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His 
385                 390                 395                 400 


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
                405                 410                 415     


Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met 
            420                 425                 430         


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
        435                 440                 445             


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
    450                 455                 460                 


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
465                 470                 475                 480 


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
                485                 490                 495     


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
            500                 505                 510         


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
        515                 520                 525             


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
    530                 535                 540                 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 


<210>  321
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1837 Activatable Proprotein construct

<400>  321

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Pro Leu Gly Leu Ala Gly 
225                 230                 235                 240 


Gly Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
                245                 250                 255     


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
            260                 265                 270         


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
        275                 280                 285             


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
    290                 295                 300                 


Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn 
305                 310                 315                 320 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
                325                 330                 335     


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
            340                 345                 350         


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser 
        355                 360                 365             


Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser Asp 
    370                 375                 380                 


Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
385                 390                 395                 400 


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
                405                 410                 415     


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
            420                 425                 430         


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
        435                 440                 445             


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
    450                 455                 460                 


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
465                 470                 475                 480 


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
                485                 490                 495     


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
            500                 505                 510         


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
        515                 520                 525             


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
    530                 535                 540                 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555 


<210>  322
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1838 Activatable Proprotein construct

<400>  322

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Pro Leu Gly Leu Ala 
225                 230                 235                 240 


Gly Gly Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu 
                245                 250                 255     


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            260                 265                 270         


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
        275                 280                 285             


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    290                 295                 300                 


Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys 
305                 310                 315                 320 


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                325                 330                 335     


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            340                 345                 350         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        355                 360                 365             


Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg Ser 
    370                 375                 380                 


Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
385                 390                 395                 400 


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
                405                 410                 415     


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu 
            420                 425                 430         


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
        435                 440                 445             


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
    450                 455                 460                 


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
465                 470                 475                 480 


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
                485                 490                 495     


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
            500                 505                 510         


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
        515                 520                 525             


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
    530                 535                 540                 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555     


<210>  323
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1839 Activatable Proprotein construct

<400>  323

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Ser Pro Leu Gly Leu Ala 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln 
                245                 250                 255     


Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly 
            260                 265                 270         


Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys 
        275                 280                 285             


Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu 
    290                 295                 300                 


Glu Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser 
305                 310                 315                 320 


Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val 
                325                 330                 335     


Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr 
            340                 345                 350         


Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr 
        355                 360                 365             


Phe Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Ser Gly Arg 
    370                 375                 380                 


Ser Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu 
385                 390                 395                 400 


Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met 
                405                 410                 415     


Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser 
            420                 425                 430         


Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn 
        435                 440                 445             


Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val 
    450                 455                 460                 


Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln 
465                 470                 475                 480 


Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg 
                485                 490                 495     


Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe 
            500                 505                 510         


Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala 
        515                 520                 525             


Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys 
    530                 535                 540                 


Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555         


<210>  324
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1840 Activatable Proprotein construct

<400>  324

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly Leu Ala Gly Gly 
225                 230                 235                 240 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
                245                 250                 255     


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            260                 265                 270         


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
        275                 280                 285             


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    290                 295                 300                 


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
305                 310                 315                 320 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                325                 330                 335     


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            340                 345                 350         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
        355                 360                 365             


Thr Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Arg Ser Asp Asn 
    370                 375                 380                 


His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His 
385                 390                 395                 400 


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
                405                 410                 415     


Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met 
            420                 425                 430         


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
        435                 440                 445             


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
    450                 455                 460                 


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
465                 470                 475                 480 


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
                485                 490                 495     


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
            500                 505                 510         


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
        515                 520                 525             


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
    530                 535                 540                 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 


<210>  325
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1841 Activatable Proprotein construct

<400>  325

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly Leu Ala Gly Gly 
225                 230                 235                 240 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
                245                 250                 255     


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            260                 265                 270         


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
        275                 280                 285             


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    290                 295                 300                 


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
305                 310                 315                 320 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                325                 330                 335     


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            340                 345                 350         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
        355                 360                 365             


Thr Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Arg Ser Asp Asn 
    370                 375                 380                 


His Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
385                 390                 395                 400 


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
                405                 410                 415     


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
            420                 425                 430         


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
        435                 440                 445             


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
    450                 455                 460                 


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
465                 470                 475                 480 


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
                485                 490                 495     


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
            500                 505                 510         


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
        515                 520                 525             


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
    530                 535                 540                 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555 


<210>  326
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1842 Activatable Proprotein construct

<400>  326

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly Leu Ala Gly Gly 
225                 230                 235                 240 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
                245                 250                 255     


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            260                 265                 270         


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
        275                 280                 285             


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    290                 295                 300                 


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
305                 310                 315                 320 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                325                 330                 335     


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            340                 345                 350         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
        355                 360                 365             


Thr Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Ser Gly Arg Ser Asp 
    370                 375                 380                 


Asn His Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
385                 390                 395                 400 


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
                405                 410                 415     


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu 
            420                 425                 430         


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
        435                 440                 445             


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
    450                 455                 460                 


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
465                 470                 475                 480 


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
                485                 490                 495     


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
            500                 505                 510         


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
        515                 520                 525             


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
    530                 535                 540                 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555     


<210>  327
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1843 Activatable Proprotein construct

<400>  327

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly Leu Ala Gly Gly 
225                 230                 235                 240 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
                245                 250                 255     


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            260                 265                 270         


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
        275                 280                 285             


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    290                 295                 300                 


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
305                 310                 315                 320 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                325                 330                 335     


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            340                 345                 350         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
        355                 360                 365             


Thr Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Ser Gly Arg Ser Asp 
    370                 375                 380                 


Asn His Gly Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu 
385                 390                 395                 400 


Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met 
                405                 410                 415     


Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser 
            420                 425                 430         


Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn 
        435                 440                 445             


Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val 
    450                 455                 460                 


Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln 
465                 470                 475                 480 


Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg 
                485                 490                 495     


Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe 
            500                 505                 510         


Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala 
        515                 520                 525             


Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys 
    530                 535                 540                 


Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555         


<210>  328
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1844 Activatable Proprotein construct

<400>  328

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly Leu Ala Gly Gly 
225                 230                 235                 240 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
                245                 250                 255     


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            260                 265                 270         


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
        275                 280                 285             


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    290                 295                 300                 


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
305                 310                 315                 320 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                325                 330                 335     


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            340                 345                 350         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
        355                 360                 365             


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Ser Gly Arg Ser 
    370                 375                 380                 


Asp Asn His Gly Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro 
385                 390                 395                 400 


Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr 
                405                 410                 415     


Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly 
            420                 425                 430         


Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp 
        435                 440                 445             


Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln 
    450                 455                 460                 


Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met 
465                 470                 475                 480 


Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys 
                485                 490                 495     


Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His 
            500                 505                 510         


Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg 
        515                 520                 525             


Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly 
    530                 535                 540                 


Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555             


<210>  329
<211>  559
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1845 Activatable Proprotein construct

<400>  329

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly Leu Ala Gly Gly 
225                 230                 235                 240 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
                245                 250                 255     


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            260                 265                 270         


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
        275                 280                 285             


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    290                 295                 300                 


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
305                 310                 315                 320 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                325                 330                 335     


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            340                 345                 350         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
        355                 360                 365             


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Ser Gly Arg Ser 
    370                 375                 380                 


Asp Asn His Gly Gly Ser Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro 
385                 390                 395                 400 


Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly 
                405                 410                 415     


Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser 
            420                 425                 430         


Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp 
        435                 440                 445             


Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys 
    450                 455                 460                 


Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu 
465                 470                 475                 480 


Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His 
                485                 490                 495     


Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr 
            500                 505                 510         


His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr 
        515                 520                 525             


Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His 
    530                 535                 540                 


Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555                 


<210>  330
<211>  559
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1846 Activatable Proprotein construct

<400>  330

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly Leu Ala Gly Gly 
225                 230                 235                 240 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
                245                 250                 255     


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            260                 265                 270         


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
        275                 280                 285             


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    290                 295                 300                 


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
305                 310                 315                 320 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
                325                 330                 335     


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            340                 345                 350         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
        355                 360                 365             


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Ser Gly Arg Ser 
    370                 375                 380                 


Asp Asn His Gly Gly Ser Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro 
385                 390                 395                 400 


Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly 
                405                 410                 415     


Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser 
            420                 425                 430         


Gly Ser Leu Tyr Met Leu Cys Thr Gly Ala Ser Ser His Ser Ser Trp 
        435                 440                 445             


Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Ala Thr Thr Lys 
    450                 455                 460                 


Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu 
465                 470                 475                 480 


Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His 
                485                 490                 495     


Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr 
            500                 505                 510         


His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr 
        515                 520                 525             


Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His 
    530                 535                 540                 


Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555                 


<210>  331
<211>  559
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1847 Activatable Proprotein construct

<400>  331

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Ser Pro Leu Gly Leu Ala Gly Gly 
225                 230                 235                 240 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
                245                 250                 255     


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            260                 265                 270         


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
        275                 280                 285             


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    290                 295                 300                 


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala His Ser Lys Asn Phe His 
305                 310                 315                 320 


Phe Asp Pro Arg Asp Val Val Ser Asn Ile Asn Val Phe Val Leu Glu 
                325                 330                 335     


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            340                 345                 350         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
        355                 360                 365             


Ile Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Ser Gly Arg Ser 
    370                 375                 380                 


Asp Asn His Gly Gly Ser Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro 
385                 390                 395                 400 


Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly 
                405                 410                 415     


Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser 
            420                 425                 430         


Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp 
        435                 440                 445             


Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys 
    450                 455                 460                 


Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu 
465                 470                 475                 480 


Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His 
                485                 490                 495     


Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr 
            500                 505                 510         


His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr 
        515                 520                 525             


Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His 
    530                 535                 540                 


Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555                 


<210>  332
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1848 Activatable Proprotein construct

<400>  332

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Pro Leu Gly Met Leu Ser 
225                 230                 235                 240 


Gly Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
                245                 250                 255     


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
            260                 265                 270         


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
        275                 280                 285             


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
    290                 295                 300                 


Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn 
305                 310                 315                 320 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
                325                 330                 335     


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
            340                 345                 350         


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser 
        355                 360                 365             


Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Ser Gly Arg 
    370                 375                 380                 


Ser Asp Asn His Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro 
385                 390                 395                 400 


Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr 
                405                 410                 415     


Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly 
            420                 425                 430         


Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp 
        435                 440                 445             


Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln 
    450                 455                 460                 


Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met 
465                 470                 475                 480 


Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys 
                485                 490                 495     


Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His 
            500                 505                 510         


Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg 
        515                 520                 525             


Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly 
    530                 535                 540                 


Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555             


<210>  333
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1849 Activatable Proprotein construct

<400>  333

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Pro Leu Gly Ile Ala Gly 
225                 230                 235                 240 


Gly Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
                245                 250                 255     


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
            260                 265                 270         


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
        275                 280                 285             


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
    290                 295                 300                 


Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn 
305                 310                 315                 320 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
                325                 330                 335     


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
            340                 345                 350         


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser 
        355                 360                 365             


Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Ser Gly Arg 
    370                 375                 380                 


Ser Asp Asn His Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro 
385                 390                 395                 400 


Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr 
                405                 410                 415     


Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly 
            420                 425                 430         


Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp 
        435                 440                 445             


Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln 
    450                 455                 460                 


Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met 
465                 470                 475                 480 


Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys 
                485                 490                 495     


Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His 
            500                 505                 510         


Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg 
        515                 520                 525             


Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly 
    530                 535                 540                 


Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555             


<210>  334
<211>  558
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1850 Activatable Proprotein construct

<400>  334

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Pro Val Gly Leu Leu Ala 
225                 230                 235                 240 


Gly Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
                245                 250                 255     


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
            260                 265                 270         


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
        275                 280                 285             


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
    290                 295                 300                 


Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn 
305                 310                 315                 320 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
                325                 330                 335     


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
            340                 345                 350         


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser 
        355                 360                 365             


Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Ser Gly Arg 
    370                 375                 380                 


Ser Asp Asn His Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro 
385                 390                 395                 400 


Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr 
                405                 410                 415     


Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly 
            420                 425                 430         


Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp 
        435                 440                 445             


Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln 
    450                 455                 460                 


Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met 
465                 470                 475                 480 


Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys 
                485                 490                 495     


Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His 
            500                 505                 510         


Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg 
        515                 520                 525             


Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly 
    530                 535                 540                 


Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555             


<210>  335
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1946 Activatable Proprotein construct

<400>  335

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
                245                 250                 255     


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
            260                 265                 270         


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
        275                 280                 285             


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
    290                 295                 300                 


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
305                 310                 315                 320 


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
                325                 330                 335     


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
            340                 345                 350         


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln 
        355                 360                 365             


Ser Ile Ile Ser Thr Leu Thr Gly Ser Gly Ser Glu Asn Leu Tyr Phe 
    370                 375                 380                 


Gln Gly Gly Ser Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
385                 390                 395                 400 


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
                405                 410                 415     


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu 
            420                 425                 430         


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
        435                 440                 445             


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
    450                 455                 460                 


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
465                 470                 475                 480 


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
                485                 490                 495     


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
            500                 505                 510         


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
        515                 520                 525             


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
    530                 535                 540                 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555     


<210>  336
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1946 cleaved protein construct

<400>  336

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
                245                 250                 255     


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
            260                 265                 270         


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
        275                 280                 285             


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
    290                 295                 300                 


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
305                 310                 315                 320 


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
                325                 330                 335     


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
            340                 345                 350         


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln 
        355                 360                 365             


Ser Ile Ile Ser Thr Leu Thr Gly Ser Gly Ser Glu Asn Leu Tyr Phe 
    370                 375                 380                 


Gln 
385 


<210>  337
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1946 cleaved protein construct

<400>  337

Gly Gly Ser Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
1               5                   10                  15      


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
            20                  25                  30          


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
        35                  40                  45              


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
    50                  55                  60                  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
65                  70                  75                  80  


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
                85                  90                  95      


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
            100                 105                 110         


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
        115                 120                 125             


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
    130                 135                 140                 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
145                 150                 155                 160 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170     


<210>  338
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1946 cleaved protein construct

<400>  338

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
                245                 250                 255     


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
            260                 265                 270         


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
        275                 280                 285             


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
    290                 295                 300                 


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
305                 310                 315                 320 


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
                325                 330                 335     


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
            340                 345                 350         


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln 
        355                 360                 365             


Ser Ile Ile Ser Thr Leu Thr Gly Ser Gly Ser Glu Asn Leu Tyr Phe 
    370                 375                 380                 


Gln Gly Gly Ser Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
385                 390                 395                 400 


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
                405                 410                 415     


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu 
            420                 425                 430         


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
        435                 440                 445             


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
    450                 455                 460                 


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
465                 470                 475                 480 


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
                485                 490                 495     


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
            500                 505                 510         


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
        515                 520                 525             


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
    530                 535                 540                 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555     


<210>  339
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1946 cleaved protein construct

<400>  339

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
                245                 250                 255     


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
            260                 265                 270         


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
        275                 280                 285             


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
    290                 295                 300                 


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
305                 310                 315                 320 


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
                325                 330                 335     


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
            340                 345                 350         


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln 
        355                 360                 365             


Ser Ile Ile Ser Thr Leu Thr Gly Ser Gly Ser Glu Asn Leu Tyr Phe 
    370                 375                 380                 


Gln 
385 


<210>  340
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1946 cleaved protein construct

<400>  340

Gly Gly Ser Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
1               5                   10                  15      


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
            20                  25                  30          


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
        35                  40                  45              


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
    50                  55                  60                  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
65                  70                  75                  80  


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
                85                  90                  95      


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
            100                 105                 110         


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
        115                 120                 125             


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
    130                 135                 140                 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
145                 150                 155                 160 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170     


<210>  341
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1947 Activatable Proprotein construct

<400>  341

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
                245                 250                 255     


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
            260                 265                 270         


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met 
        275                 280                 285             


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
    290                 295                 300                 


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
305                 310                 315                 320 


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
                325                 330                 335     


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
            340                 345                 350         


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln 
        355                 360                 365             


Ser Ile Ile Ser Thr Leu Thr Gly Ser Gly Ser Glu Asn Leu Tyr Phe 
    370                 375                 380                 


Gln Gly Gly Ser Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
385                 390                 395                 400 


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
                405                 410                 415     


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu 
            420                 425                 430         


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
        435                 440                 445             


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
    450                 455                 460                 


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
465                 470                 475                 480 


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
                485                 490                 495     


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
            500                 505                 510         


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
        515                 520                 525             


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
    530                 535                 540                 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555     


<210>  342
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1948 Activatable Proprotein construct

<400>  342

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
                245                 250                 255     


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
            260                 265                 270         


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Ala Met 
        275                 280                 285             


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
    290                 295                 300                 


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
305                 310                 315                 320 


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
                325                 330                 335     


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
            340                 345                 350         


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln 
        355                 360                 365             


Ser Ile Ile Ser Thr Leu Thr Gly Ser Gly Ser Glu Asn Leu Tyr Phe 
    370                 375                 380                 


Gln Gly Gly Ser Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
385                 390                 395                 400 


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
                405                 410                 415     


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu 
            420                 425                 430         


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
        435                 440                 445             


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
    450                 455                 460                 


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
465                 470                 475                 480 


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
                485                 490                 495     


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
            500                 505                 510         


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
        515                 520                 525             


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
    530                 535                 540                 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555     


<210>  343
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1949 Activatable Proprotein construct

<400>  343

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
                245                 250                 255     


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
            260                 265                 270         


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Ala Met 
        275                 280                 285             


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
    290                 295                 300                 


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
305                 310                 315                 320 


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
                325                 330                 335     


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
            340                 345                 350         


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln 
        355                 360                 365             


Ser Ile Ile Ser Thr Leu Thr Gly Ser Gly Ser Glu Asn Leu Tyr Phe 
    370                 375                 380                 


Gln Gly Gly Ser Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
385                 390                 395                 400 


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
                405                 410                 415     


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu 
            420                 425                 430         


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
        435                 440                 445             


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
    450                 455                 460                 


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
465                 470                 475                 480 


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
                485                 490                 495     


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
            500                 505                 510         


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
        515                 520                 525             


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
    530                 535                 540                 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555     


<210>  344
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501950 Activatable Proprotein construct

<400>  344

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ala Tyr Ser Tyr Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  345
<211>  779
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501950 Activatable Proprotein construct

<400>  345

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Glu Pro 
    210                 215                 220                 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Gly Gly Ser Pro Leu Gly Leu Ala Gly Gly Gly 
    450                 455                 460                 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
465                 470                 475                 480 


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
                485                 490                 495     


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
            500                 505                 510         


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
        515                 520                 525             


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
    530                 535                 540                 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
545                 550                 555                 560 


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
                565                 570                 575     


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
            580                 585                 590         


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        595                 600                 605             


Ser Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
    610                 615                 620                 


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
625                 630                 635                 640 


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
                645                 650                 655     


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
            660                 665                 670         


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
        675                 680                 685             


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
    690                 695                 700                 


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
705                 710                 715                 720 


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
                725                 730                 735     


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
            740                 745                 750         


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
        755                 760                 765             


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
    770                 775                 


<210>  346
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501950 cleaved protein construct

<400>  346

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ala Tyr Ser Tyr Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  347
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501950 cleaved protein construct

<400>  347

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Glu Pro 
    210                 215                 220                 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Gly Gly Ser Pro Leu Gly 
    450                 455                 


<210>  348
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501950 cleaved protein construct

<400>  348

Leu Ala Gly Gly Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr 
1               5                   10                  15      


Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn 
            20                  25                  30          


Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe 
        35                  40                  45              


Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys 
    50                  55                  60                  


Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro 
65                  70                  75                  80  


Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
                85                  90                  95      


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
            100                 105                 110         


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
        115                 120                 125             


Thr Phe Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp 
145                 150                 155                 160 


Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu 
                165                 170                 175     


Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys 
            180                 185                 190         


Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser 
        195                 200                 205             


Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr 
    210                 215                 220                 


Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr 
225                 230                 235                 240 


Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly 
                245                 250                 255     


His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile 
            260                 265                 270         


Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly 
        275                 280                 285             


Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr 
    290                 295                 300                 


His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
305                 310                 315                 320 


<210>  349
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501950 cleaved protein construct

<400>  349

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ala Tyr Ser Tyr Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  350
<211>  779
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501950 cleaved protein construct

<400>  350

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Glu Pro 
    210                 215                 220                 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Gly Gly Ser Pro Leu Gly Leu Ala Gly Gly Gly 
    450                 455                 460                 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
465                 470                 475                 480 


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
                485                 490                 495     


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
            500                 505                 510         


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
        515                 520                 525             


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
    530                 535                 540                 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
545                 550                 555                 560 


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
                565                 570                 575     


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
            580                 585                 590         


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        595                 600                 605             


Ser Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
    610                 615                 620                 


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
625                 630                 635                 640 


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
                645                 650                 655     


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
            660                 665                 670         


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
        675                 680                 685             


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
    690                 695                 700                 


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
705                 710                 715                 720 


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
                725                 730                 735     


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
            740                 745                 750         


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
        755                 760                 765             


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
    770                 775                 


<210>  351
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501950 cleaved protein construct

<400>  351

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Glu Pro 
    210                 215                 220                 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Gly Gly Ser Pro Leu Gly 
    450                 455                 


<210>  352
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501950 cleaved protein construct

<400>  352

Leu Ala Gly Gly Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr 
1               5                   10                  15      


Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn 
            20                  25                  30          


Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe 
        35                  40                  45              


Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys 
    50                  55                  60                  


Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro 
65                  70                  75                  80  


Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
                85                  90                  95      


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
            100                 105                 110         


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
        115                 120                 125             


Thr Phe Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp 
145                 150                 155                 160 


Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu 
                165                 170                 175     


Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys 
            180                 185                 190         


Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser 
        195                 200                 205             


Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr 
    210                 215                 220                 


Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr 
225                 230                 235                 240 


Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly 
                245                 250                 255     


His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile 
            260                 265                 270         


Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly 
        275                 280                 285             


Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr 
    290                 295                 300                 


His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
305                 310                 315                 320 


<210>  353
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501951 Activatable Proprotein construct

<400>  353

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ala Tyr Ser Tyr Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  354
<211>  779
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501951 Activatable Proprotein construct

<400>  354

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Glu Pro 
    210                 215                 220                 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Gly Gly Ser Gly Arg Ser Asp Asn His Gly Gly 
    450                 455                 460                 


Ala Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
465                 470                 475                 480 


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
                485                 490                 495     


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
            500                 505                 510         


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
        515                 520                 525             


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
    530                 535                 540                 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
545                 550                 555                 560 


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
                565                 570                 575     


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
            580                 585                 590         


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        595                 600                 605             


Ser Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
    610                 615                 620                 


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
625                 630                 635                 640 


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
                645                 650                 655     


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
            660                 665                 670         


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
        675                 680                 685             


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
    690                 695                 700                 


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
705                 710                 715                 720 


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
                725                 730                 735     


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
            740                 745                 750         


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
        755                 760                 765             


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
    770                 775                 


<210>  355
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501951 cleaved protein construct

<400>  355

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ala Tyr Ser Tyr Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  356
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501951 cleaved protein construct

<400>  356

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Glu Pro 
    210                 215                 220                 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Gly Gly Ser Gly Arg 
    450                 455             


<210>  357
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501951 cleaved protein construct

<400>  357

Ser Asp Asn His Gly Gly Ala Ala Pro Ala Ser Ser Ser Thr Lys Lys 
1               5                   10                  15      


Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu 
            20                  25                  30          


Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr 
        35                  40                  45              


Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln 
    50                  55                  60                  


Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala 
65                  70                  75                  80  


Pro Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile 
                85                  90                  95      


Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys 
            100                 105                 110         


Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp 
        115                 120                 125             


Ile Thr Phe Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ala Glu Leu Cys Asp Asp 
145                 150                 155                 160 


Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys 
                165                 170                 175     


Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile 
            180                 185                 190         


Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser 
        195                 200                 205             


Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr 
    210                 215                 220                 


Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr 
225                 230                 235                 240 


Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro 
                245                 250                 255     


Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg 
            260                 265                 270         


Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln 
        275                 280                 285             


Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met 
    290                 295                 300                 


Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly 
305                 310                 315                 320 


Glu 
    


<210>  358
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501951 cleaved protein construct

<400>  358

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ala Tyr Ser Tyr Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  359
<211>  779
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501951 cleaved protein construct

<400>  359

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Glu Pro 
    210                 215                 220                 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Gly Gly Ser Gly Arg Ser Asp Asn His Gly Gly 
    450                 455                 460                 


Ala Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
465                 470                 475                 480 


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
                485                 490                 495     


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
            500                 505                 510         


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
        515                 520                 525             


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
    530                 535                 540                 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
545                 550                 555                 560 


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
                565                 570                 575     


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
            580                 585                 590         


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        595                 600                 605             


Ser Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
    610                 615                 620                 


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
625                 630                 635                 640 


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
                645                 650                 655     


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
            660                 665                 670         


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
        675                 680                 685             


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
    690                 695                 700                 


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
705                 710                 715                 720 


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
                725                 730                 735     


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
            740                 745                 750         


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
        755                 760                 765             


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
    770                 775                 


<210>  360
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501951 cleaved protein construct

<400>  360

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Glu Pro 
    210                 215                 220                 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Gly Gly Ser Gly Arg 
    450                 455             


<210>  361
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501951 cleaved protein construct

<400>  361

Ser Asp Asn His Gly Gly Ala Ala Pro Ala Ser Ser Ser Thr Lys Lys 
1               5                   10                  15      


Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu 
            20                  25                  30          


Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr 
        35                  40                  45              


Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln 
    50                  55                  60                  


Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala 
65                  70                  75                  80  


Pro Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile 
                85                  90                  95      


Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys 
            100                 105                 110         


Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp 
        115                 120                 125             


Ile Thr Phe Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ala Glu Leu Cys Asp Asp 
145                 150                 155                 160 


Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys 
                165                 170                 175     


Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile 
            180                 185                 190         


Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser 
        195                 200                 205             


Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr 
    210                 215                 220                 


Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr 
225                 230                 235                 240 


Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro 
                245                 250                 255     


Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg 
            260                 265                 270         


Ile Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln 
        275                 280                 285             


Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met 
    290                 295                 300                 


Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly 
305                 310                 315                 320 


Glu 
    


<210>  362
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501951 cleaved protein construct

<400>  362

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ala Tyr Ser Tyr Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  363
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501951 cleaved protein construct

<400>  363

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Glu Pro 
    210                 215                 220                 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Gly Gly Ser Gly Arg Ser Asp Asn 
    450                 455                 460     


<210>  364
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501951 cleaved protein construct

<400>  364

His Gly Gly Ala Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro 
145                 150                 155                 160 


Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr 
                165                 170                 175     


Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly 
            180                 185                 190         


Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp 
        195                 200                 205             


Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln 
    210                 215                 220                 


Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met 
225                 230                 235                 240 


Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys 
                245                 250                 255     


Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His 
            260                 265                 270         


Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg 
        275                 280                 285             


Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly 
    290                 295                 300                 


Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
305                 310                 315             


<210>  365
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501951 cleaved protein construct

<400>  365

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ala Tyr Ser Tyr Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  366
<211>  779
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501951 cleaved protein construct

<400>  366

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Glu Pro 
    210                 215                 220                 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Gly Gly Ser Gly Arg Ser Asp Asn His Gly Gly 
    450                 455                 460                 


Ala Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
465                 470                 475                 480 


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
                485                 490                 495     


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
            500                 505                 510         


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
        515                 520                 525             


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
    530                 535                 540                 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
545                 550                 555                 560 


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
                565                 570                 575     


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
            580                 585                 590         


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        595                 600                 605             


Ser Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
    610                 615                 620                 


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
625                 630                 635                 640 


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
                645                 650                 655     


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
            660                 665                 670         


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
        675                 680                 685             


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
    690                 695                 700                 


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
705                 710                 715                 720 


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
                725                 730                 735     


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
            740                 745                 750         


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
        755                 760                 765             


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
    770                 775                 


<210>  367
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501951 cleaved protein construct

<400>  367

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Glu Pro 
    210                 215                 220                 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Gly Gly Ser Gly Arg Ser Asp Asn 
    450                 455                 460     


<210>  368
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501951 cleaved protein construct

<400>  368

His Gly Gly Ala Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu 
1               5                   10                  15      


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            20                  25                  30          


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
        35                  40                  45              


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    50                  55                  60                  


Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys 
65                  70                  75                  80  


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                85                  90                  95      


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            100                 105                 110         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        115                 120                 125             


Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro 
145                 150                 155                 160 


Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr 
                165                 170                 175     


Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly 
            180                 185                 190         


Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp 
        195                 200                 205             


Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln 
    210                 215                 220                 


Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met 
225                 230                 235                 240 


Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys 
                245                 250                 255     


Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His 
            260                 265                 270         


Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg 
        275                 280                 285             


Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly 
    290                 295                 300                 


Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
305                 310                 315             


<210>  369
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501952 Activatable Proprotein construct

<400>  369

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ala Tyr Ser Tyr Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  370
<211>  779
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501952 Activatable Proprotein construct

<400>  370

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Glu Pro 
    210                 215                 220                 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    450                 455                 460                 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
465                 470                 475                 480 


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
                485                 490                 495     


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
            500                 505                 510         


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
        515                 520                 525             


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
    530                 535                 540                 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
545                 550                 555                 560 


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
                565                 570                 575     


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
            580                 585                 590         


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Gly Pro Leu Gly Leu 
        595                 600                 605             


Ala Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
    610                 615                 620                 


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
625                 630                 635                 640 


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
                645                 650                 655     


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
            660                 665                 670         


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
        675                 680                 685             


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
    690                 695                 700                 


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
705                 710                 715                 720 


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
                725                 730                 735     


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
            740                 745                 750         


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
        755                 760                 765             


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
    770                 775                 


<210>  371
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501952 cleaved protein construct

<400>  371

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ala Tyr Ser Tyr Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  372
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501952 cleaved protein construct

<400>  372

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Glu Pro 
    210                 215                 220                 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    450                 455                 460                 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
465                 470                 475                 480 


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
                485                 490                 495     


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
            500                 505                 510         


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
        515                 520                 525             


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
    530                 535                 540                 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
545                 550                 555                 560 


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
                565                 570                 575     


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
            580                 585                 590         


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Gly Pro Leu Gly 
        595                 600                 605         


<210>  373
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501952 cleaved protein construct

<400>  373

Leu Ala Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
1               5                   10                  15      


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
            20                  25                  30          


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu 
        35                  40                  45              


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
    50                  55                  60                  


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
65                  70                  75                  80  


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
                85                  90                  95      


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
            100                 105                 110         


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
        115                 120                 125             


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
    130                 135                 140                 


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
145                 150                 155                 160 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170         


<210>  374
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501952 cleaved protein construct

<400>  374

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ala Tyr Ser Tyr Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  375
<211>  779
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501952 cleaved protein construct

<400>  375

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Glu Pro 
    210                 215                 220                 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    450                 455                 460                 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
465                 470                 475                 480 


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
                485                 490                 495     


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
            500                 505                 510         


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
        515                 520                 525             


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
    530                 535                 540                 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
545                 550                 555                 560 


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
                565                 570                 575     


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
            580                 585                 590         


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Gly Pro Leu Gly Leu 
        595                 600                 605             


Ala Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
    610                 615                 620                 


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
625                 630                 635                 640 


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
                645                 650                 655     


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
            660                 665                 670         


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
        675                 680                 685             


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
    690                 695                 700                 


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
705                 710                 715                 720 


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
                725                 730                 735     


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
            740                 745                 750         


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
        755                 760                 765             


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
    770                 775                 


<210>  376
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501952 cleaved protein construct

<400>  376

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Glu Pro 
    210                 215                 220                 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    450                 455                 460                 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
465                 470                 475                 480 


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
                485                 490                 495     


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
            500                 505                 510         


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
        515                 520                 525             


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
    530                 535                 540                 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
545                 550                 555                 560 


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
                565                 570                 575     


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
            580                 585                 590         


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Gly Pro Leu Gly 
        595                 600                 605         


<210>  377
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501952 cleaved protein construct

<400>  377

Leu Ala Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
1               5                   10                  15      


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
            20                  25                  30          


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu 
        35                  40                  45              


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
    50                  55                  60                  


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
65                  70                  75                  80  


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
                85                  90                  95      


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
            100                 105                 110         


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
        115                 120                 125             


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
    130                 135                 140                 


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
145                 150                 155                 160 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170         


<210>  378
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501953 Activatable Proprotein construct

<400>  378

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ala Tyr Ser Tyr Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  379
<211>  779
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501953 Activatable Proprotein construct

<400>  379

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Glu Pro 
    210                 215                 220                 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    450                 455                 460                 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
465                 470                 475                 480 


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
                485                 490                 495     


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
            500                 505                 510         


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
        515                 520                 525             


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
    530                 535                 540                 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
545                 550                 555                 560 


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
                565                 570                 575     


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
            580                 585                 590         


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Arg Ser Asp 
        595                 600                 605             


Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
    610                 615                 620                 


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
625                 630                 635                 640 


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
                645                 650                 655     


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
            660                 665                 670         


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
        675                 680                 685             


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
    690                 695                 700                 


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
705                 710                 715                 720 


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
                725                 730                 735     


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
            740                 745                 750         


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
        755                 760                 765             


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
    770                 775                 


<210>  380
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501953 cleaved protein construct

<400>  380

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ala Tyr Ser Tyr Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  381
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501953 cleaved protein construct

<400>  381

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Glu Pro 
    210                 215                 220                 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    450                 455                 460                 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
465                 470                 475                 480 


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
                485                 490                 495     


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
            500                 505                 510         


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
        515                 520                 525             


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
    530                 535                 540                 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
545                 550                 555                 560 


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
                565                 570                 575     


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
            580                 585                 590         


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Arg 
        595                 600                 605     


<210>  382
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501953 cleaved protein construct

<400>  382

Ser Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu 
1               5                   10                  15      


Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met 
            20                  25                  30          


Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser 
        35                  40                  45              


Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn 
    50                  55                  60                  


Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val 
65                  70                  75                  80  


Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln 
                85                  90                  95      


Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg 
            100                 105                 110         


Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe 
        115                 120                 125             


Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala 
    130                 135                 140                 


Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys 
145                 150                 155                 160 


Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170             


<210>  383
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501953 cleaved protein construct

<400>  383

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ala Tyr Ser Tyr Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  384
<211>  779
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501953 cleaved protein construct

<400>  384

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Glu Pro 
    210                 215                 220                 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    450                 455                 460                 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
465                 470                 475                 480 


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
                485                 490                 495     


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
            500                 505                 510         


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
        515                 520                 525             


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
    530                 535                 540                 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
545                 550                 555                 560 


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
                565                 570                 575     


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
            580                 585                 590         


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Arg Ser Asp 
        595                 600                 605             


Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
    610                 615                 620                 


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
625                 630                 635                 640 


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
                645                 650                 655     


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
            660                 665                 670         


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
        675                 680                 685             


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
    690                 695                 700                 


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
705                 710                 715                 720 


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
                725                 730                 735     


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
            740                 745                 750         


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
        755                 760                 765             


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
    770                 775                 


<210>  385
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501953 cleaved protein construct

<400>  385

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Glu Pro 
    210                 215                 220                 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    450                 455                 460                 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
465                 470                 475                 480 


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
                485                 490                 495     


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
            500                 505                 510         


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
        515                 520                 525             


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
    530                 535                 540                 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
545                 550                 555                 560 


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
                565                 570                 575     


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
            580                 585                 590         


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Arg 
        595                 600                 605     


<210>  386
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501953 cleaved protein construct

<400>  386

Ser Asp Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu 
1               5                   10                  15      


Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met 
            20                  25                  30          


Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser 
        35                  40                  45              


Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn 
    50                  55                  60                  


Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val 
65                  70                  75                  80  


Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln 
                85                  90                  95      


Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg 
            100                 105                 110         


Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe 
        115                 120                 125             


Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala 
    130                 135                 140                 


Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys 
145                 150                 155                 160 


Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170             


<210>  387
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501953 cleaved protein construct

<400>  387

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ala Tyr Ser Tyr Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  388
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501953 cleaved protein construct

<400>  388

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Glu Pro 
    210                 215                 220                 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    450                 455                 460                 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
465                 470                 475                 480 


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
                485                 490                 495     


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
            500                 505                 510         


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
        515                 520                 525             


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
    530                 535                 540                 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
545                 550                 555                 560 


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
                565                 570                 575     


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
            580                 585                 590         


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Arg Ser Asp 
        595                 600                 605             


Asn 
    


<210>  389
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501953 cleaved protein construct

<400>  389

His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His 
1               5                   10                  15      


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
            20                  25                  30          


Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met 
        35                  40                  45              


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
    50                  55                  60                  


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
65                  70                  75                  80  


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
                85                  90                  95      


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
            100                 105                 110         


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
        115                 120                 125             


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
    130                 135                 140                 


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
145                 150                 155                 160 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170 


<210>  390
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501953 cleaved protein construct

<400>  390

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ala Tyr Ser Tyr Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  391
<211>  779
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501953 cleaved protein construct

<400>  391

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Glu Pro 
    210                 215                 220                 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    450                 455                 460                 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
465                 470                 475                 480 


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
                485                 490                 495     


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
            500                 505                 510         


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
        515                 520                 525             


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
    530                 535                 540                 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
545                 550                 555                 560 


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
                565                 570                 575     


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
            580                 585                 590         


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Arg Ser Asp 
        595                 600                 605             


Asn His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
    610                 615                 620                 


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
625                 630                 635                 640 


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
                645                 650                 655     


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
            660                 665                 670         


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
        675                 680                 685             


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
    690                 695                 700                 


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
705                 710                 715                 720 


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
                725                 730                 735     


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
            740                 745                 750         


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
        755                 760                 765             


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
    770                 775                 


<210>  392
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501953 cleaved protein construct

<400>  392

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Glu Asn 
            20                  25                  30          


Ile Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Glu Pro 
    210                 215                 220                 


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    450                 455                 460                 


Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
465                 470                 475                 480 


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
                485                 490                 495     


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
            500                 505                 510         


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
        515                 520                 525             


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
    530                 535                 540                 


Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu 
545                 550                 555                 560 


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
                565                 570                 575     


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
            580                 585                 590         


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Arg Ser Asp 
        595                 600                 605             


Asn 
    


<210>  393
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P14501953 cleaved protein construct

<400>  393

His Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His 
1               5                   10                  15      


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
            20                  25                  30          


Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met 
        35                  40                  45              


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
    50                  55                  60                  


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
65                  70                  75                  80  


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
                85                  90                  95      


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
            100                 105                 110         


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
        115                 120                 125             


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
    130                 135                 140                 


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
145                 150                 155                 160 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170 


<210>  394
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1972 Activatable Proprotein construct

<400>  394

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
                245                 250                 255     


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
            260                 265                 270         


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
        275                 280                 285             


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Ser Glu 
    290                 295                 300                 


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
305                 310                 315                 320 


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
                325                 330                 335     


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
            340                 345                 350         


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln 
        355                 360                 365             


Ser Ile Ile Ser Thr Leu Thr Gly Ser Gly Ser Glu Asn Leu Tyr Phe 
    370                 375                 380                 


Gln Gly Gly Ser Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
385                 390                 395                 400 


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
                405                 410                 415     


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Ser Ser Gly Ser Leu 
            420                 425                 430         


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
        435                 440                 445             


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
    450                 455                 460                 


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
465                 470                 475                 480 


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
                485                 490                 495     


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
            500                 505                 510         


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
        515                 520                 525             


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
    530                 535                 540                 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555     


<210>  395
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1972 cleaved protein construct

<400>  395

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
                245                 250                 255     


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
            260                 265                 270         


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
        275                 280                 285             


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Ser Glu 
    290                 295                 300                 


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
305                 310                 315                 320 


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
                325                 330                 335     


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
            340                 345                 350         


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln 
        355                 360                 365             


Ser Ile Ile Ser Thr Leu Thr Gly Ser Gly Ser Glu Asn Leu Tyr Phe 
    370                 375                 380                 


Gln 
385 


<210>  396
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1972 cleaved protein construct

<400>  396

Gly Gly Ser Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
1               5                   10                  15      


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
            20                  25                  30          


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Ser Ser Gly Ser Leu Tyr 
        35                  40                  45              


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
    50                  55                  60                  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
65                  70                  75                  80  


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
                85                  90                  95      


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
            100                 105                 110         


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
        115                 120                 125             


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
    130                 135                 140                 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
145                 150                 155                 160 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170     


<210>  397
<211>  556
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1972 cleaved protein construct

<400>  397

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
                245                 250                 255     


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
            260                 265                 270         


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
        275                 280                 285             


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Ser Glu 
    290                 295                 300                 


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
305                 310                 315                 320 


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
                325                 330                 335     


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
            340                 345                 350         


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln 
        355                 360                 365             


Ser Ile Ile Ser Thr Leu Thr Gly Ser Gly Ser Glu Asn Leu Tyr Phe 
    370                 375                 380                 


Gln Gly Gly Ser Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
385                 390                 395                 400 


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
                405                 410                 415     


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Ser Ser Gly Ser Leu 
            420                 425                 430         


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
        435                 440                 445             


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
    450                 455                 460                 


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
465                 470                 475                 480 


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
                485                 490                 495     


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
            500                 505                 510         


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
        515                 520                 525             


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
    530                 535                 540                 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555     


<210>  398
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1972 cleaved protein construct

<400>  398

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
                245                 250                 255     


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
            260                 265                 270         


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
        275                 280                 285             


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Ser Glu 
    290                 295                 300                 


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
305                 310                 315                 320 


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
                325                 330                 335     


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
            340                 345                 350         


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln 
        355                 360                 365             


Ser Ile Ile Ser Thr Leu Thr Gly Ser Gly Ser Glu Asn Leu Tyr Phe 
    370                 375                 380                 


Gln 
385 


<210>  399
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P1972 cleaved protein construct

<400>  399

Gly Gly Ser Gly Ser Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
1               5                   10                  15      


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
            20                  25                  30          


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Ser Ser Gly Ser Leu Tyr 
        35                  40                  45              


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
    50                  55                  60                  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
65                  70                  75                  80  


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
                85                  90                  95      


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
            100                 105                 110         


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
        115                 120                 125             


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
    130                 135                 140                 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
145                 150                 155                 160 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170     


<210>  400
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2008 Activatable Proprotein construct

<400>  400

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Pro Leu Gly Leu Ala Gly 
225                 230                 235                 240 


Gly Gly Ser Ala Ala Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
                245                 250                 255     


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
            260                 265                 270         


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr 
        275                 280                 285             


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
    290                 295                 300                 


Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn 
305                 310                 315                 320 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
                325                 330                 335     


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
            340                 345                 350         


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser 
        355                 360                 365             


Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Gly 
    370                 375                 380                 


Ser Gly Gly Ser Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu 
385                 390                 395                 400 


Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met 
                405                 410                 415     


Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser 
            420                 425                 430         


Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn 
        435                 440                 445             


Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val 
    450                 455                 460                 


Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln 
465                 470                 475                 480 


Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg 
                485                 490                 495     


Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe 
            500                 505                 510         


Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala 
        515                 520                 525             


Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys 
    530                 535                 540                 


Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555         


<210>  401
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2009 Activatable Proprotein construct

<400>  401

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Pro Leu Gly Leu Ala Gly 
225                 230                 235                 240 


Gly Gly Ser Ala Ala Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
                245                 250                 255     


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
            260                 265                 270         


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
        275                 280                 285             


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
    290                 295                 300                 


Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn 
305                 310                 315                 320 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
                325                 330                 335     


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
            340                 345                 350         


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser 
        355                 360                 365             


Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Gly 
    370                 375                 380                 


Ser Gly Gly Ser Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu 
385                 390                 395                 400 


Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met 
                405                 410                 415     


Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser 
            420                 425                 430         


Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn 
        435                 440                 445             


Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val 
    450                 455                 460                 


Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln 
465                 470                 475                 480 


Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg 
                485                 490                 495     


Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe 
            500                 505                 510         


Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala 
        515                 520                 525             


Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys 
    530                 535                 540                 


Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555         


<210>  402
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2010 Activatable Proprotein construct

<400>  402

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Pro Leu Gly Leu Ala Gly 
225                 230                 235                 240 


Gly Gly Ser Ala Ala Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
                245                 250                 255     


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
            260                 265                 270         


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
        275                 280                 285             


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
    290                 295                 300                 


Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn 
305                 310                 315                 320 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
                325                 330                 335     


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
            340                 345                 350         


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser 
        355                 360                 365             


Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Gly 
    370                 375                 380                 


Ser Gly Gly Ser Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu 
385                 390                 395                 400 


Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met 
                405                 410                 415     


Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser 
            420                 425                 430         


Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn 
        435                 440                 445             


Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val 
    450                 455                 460                 


Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln 
465                 470                 475                 480 


Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg 
                485                 490                 495     


Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe 
            500                 505                 510         


Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala 
        515                 520                 525             


Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys 
    530                 535                 540                 


Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555         


<210>  403
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2011 Activatable Proprotein construct

<400>  403

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Ser Ala Ala Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
                245                 250                 255     


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
            260                 265                 270         


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
        275                 280                 285             


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
    290                 295                 300                 


Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn 
305                 310                 315                 320 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
                325                 330                 335     


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
            340                 345                 350         


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser 
        355                 360                 365             


Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Pro Leu 
    370                 375                 380                 


Gly Leu Ala Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu 
385                 390                 395                 400 


Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met 
                405                 410                 415     


Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser 
            420                 425                 430         


Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn 
        435                 440                 445             


Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val 
    450                 455                 460                 


Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln 
465                 470                 475                 480 


Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg 
                485                 490                 495     


Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe 
            500                 505                 510         


Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala 
        515                 520                 525             


Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys 
    530                 535                 540                 


Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555         


<210>  404
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2012 Activatable Proprotein construct

<400>  404

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Pro Leu Gly Leu Ala Gly 
225                 230                 235                 240 


Gly Gly Ser Ala Ala Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
                245                 250                 255     


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
            260                 265                 270         


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
        275                 280                 285             


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
    290                 295                 300                 


Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn 
305                 310                 315                 320 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
                325                 330                 335     


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
            340                 345                 350         


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser 
        355                 360                 365             


Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Pro Leu 
    370                 375                 380                 


Gly Leu Ala Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu 
385                 390                 395                 400 


Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met 
                405                 410                 415     


Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser 
            420                 425                 430         


Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn 
        435                 440                 445             


Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val 
    450                 455                 460                 


Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln 
465                 470                 475                 480 


Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg 
                485                 490                 495     


Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe 
            500                 505                 510         


Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala 
        515                 520                 525             


Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys 
    530                 535                 540                 


Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555         


<210>  405
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2013 Activatable Proprotein construct

<400>  405

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Pro Leu Gly Leu Ala Gly 
225                 230                 235                 240 


Gly Gly Ser Ala Ala Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
                245                 250                 255     


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
            260                 265                 270         


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
        275                 280                 285             


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
    290                 295                 300                 


Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn 
305                 310                 315                 320 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
                325                 330                 335     


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
            340                 345                 350         


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser 
        355                 360                 365             


Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Gly 
    370                 375                 380                 


Ser Gly Gly Ser Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu 
385                 390                 395                 400 


Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met 
                405                 410                 415     


Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser 
            420                 425                 430         


Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn 
        435                 440                 445             


Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val 
    450                 455                 460                 


Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln 
465                 470                 475                 480 


Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg 
                485                 490                 495     


Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe 
            500                 505                 510         


Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala 
        515                 520                 525             


Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys 
    530                 535                 540                 


Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555         


<210>  406
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2236 Activatable Proprotein construct

<400>  406

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser Pro Leu Gly Leu Ala 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
                245                 250                 255     


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            260                 265                 270         


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
        275                 280                 285             


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    290                 295                 300                 


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
305                 310                 315                 320 


Leu Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu 
                325                 330                 335     


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            340                 345                 350         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
        355                 360                 365             


Ile Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ala Glu Leu Cys Asp Asp Ala Pro Pro Glu Ile Pro 
385                 390                 395                 400 


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
                405                 410                 415     


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
            420                 425                 430         


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
        435                 440                 445             


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
    450                 455                 460                 


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
465                 470                 475                 480 


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
                485                 490                 495     


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
            500                 505                 510         


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
        515                 520                 525             


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
    530                 535                 540                 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555 


<210>  407
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2237 Activatable Proprotein construct

<400>  407

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser Pro Leu Gly Leu Ala 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
                245                 250                 255     


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            260                 265                 270         


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
        275                 280                 285             


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    290                 295                 300                 


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
305                 310                 315                 320 


Leu Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu 
                325                 330                 335     


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            340                 345                 350         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
        355                 360                 365             


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ala Glu Leu Cys Asp Asp Ala Pro Pro Glu Ile Pro 
385                 390                 395                 400 


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
                405                 410                 415     


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
            420                 425                 430         


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
        435                 440                 445             


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
    450                 455                 460                 


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
465                 470                 475                 480 


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
                485                 490                 495     


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
            500                 505                 510         


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
        515                 520                 525             


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
    530                 535                 540                 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555 


<210>  408
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2238 Activatable Proprotein construct

<400>  408

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser Pro Leu Gly Leu Ala 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
                245                 250                 255     


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            260                 265                 270         


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
        275                 280                 285             


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    290                 295                 300                 


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
305                 310                 315                 320 


Leu Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu 
                325                 330                 335     


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            340                 345                 350         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
        355                 360                 365             


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ala Glu Leu Cys Asp Asp Lys Pro Pro Glu Ile Pro 
385                 390                 395                 400 


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
                405                 410                 415     


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
            420                 425                 430         


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
        435                 440                 445             


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
    450                 455                 460                 


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
465                 470                 475                 480 


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
                485                 490                 495     


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
            500                 505                 510         


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
        515                 520                 525             


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
    530                 535                 540                 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555 


<210>  409
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2239 Activatable Proprotein construct

<400>  409

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser Pro Leu Gly Leu Ala 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
                245                 250                 255     


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            260                 265                 270         


Lys Asn Pro Lys Leu Thr Glu Met Leu Thr Phe Lys Phe Tyr Met Pro 
        275                 280                 285             


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    290                 295                 300                 


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
305                 310                 315                 320 


Leu Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu 
                325                 330                 335     


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            340                 345                 350         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
        355                 360                 365             


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ala Glu Leu Cys Asp Asp Lys Pro Pro Glu Ile Pro 
385                 390                 395                 400 


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
                405                 410                 415     


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
            420                 425                 430         


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
        435                 440                 445             


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
    450                 455                 460                 


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
465                 470                 475                 480 


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
                485                 490                 495     


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
            500                 505                 510         


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
        515                 520                 525             


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
    530                 535                 540                 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555 


<210>  410
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2240 Activatable Proprotein construct

<400>  410

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser Pro Leu Gly Leu Ala 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
                245                 250                 255     


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            260                 265                 270         


Lys Asn Pro Lys Leu Thr Glu Met Leu Thr Phe Lys Phe Tyr Met Pro 
        275                 280                 285             


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    290                 295                 300                 


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
305                 310                 315                 320 


Leu Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu 
                325                 330                 335     


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            340                 345                 350         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
        355                 360                 365             


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ala Glu Leu Cys Asp Asp Lys Pro Pro Glu Ile Pro 
385                 390                 395                 400 


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
                405                 410                 415     


Cys Ala Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
            420                 425                 430         


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
        435                 440                 445             


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
    450                 455                 460                 


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
465                 470                 475                 480 


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
                485                 490                 495     


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
            500                 505                 510         


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
        515                 520                 525             


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
    530                 535                 540                 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555 


<210>  411
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2241 Activatable Proprotein construct

<400>  411

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser Pro Leu Gly Leu Ala 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
                245                 250                 255     


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            260                 265                 270         


Lys Asn Pro Lys Leu Thr Glu Met Leu Thr Phe Lys Phe Tyr Met Pro 
        275                 280                 285             


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    290                 295                 300                 


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
305                 310                 315                 320 


Leu Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu 
                325                 330                 335     


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            340                 345                 350         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
        355                 360                 365             


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ala Glu Leu Cys Asp Asp Lys Pro Pro Glu Ile Pro 
385                 390                 395                 400 


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
                405                 410                 415     


Cys Glu Cys Lys Arg Gly Phe Arg Ala Ile Lys Ser Gly Ser Leu Tyr 
            420                 425                 430         


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
        435                 440                 445             


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
    450                 455                 460                 


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
465                 470                 475                 480 


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
                485                 490                 495     


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
            500                 505                 510         


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
        515                 520                 525             


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
    530                 535                 540                 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555 


<210>  412
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2242 Activatable Proprotein construct

<400>  412

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser Pro Leu Gly Leu Ala 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
                245                 250                 255     


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            260                 265                 270         


Lys Asn Pro Lys Leu Thr Glu Met Leu Thr Phe Lys Phe Tyr Met Pro 
        275                 280                 285             


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    290                 295                 300                 


Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His 
305                 310                 315                 320 


Leu Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu 
                325                 330                 335     


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            340                 345                 350         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
        355                 360                 365             


Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ala Glu Leu Cys Asp Asp Lys Pro Pro Glu Ile Pro 
385                 390                 395                 400 


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
                405                 410                 415     


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Ala Ser Gly Ser Leu Tyr 
            420                 425                 430         


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
        435                 440                 445             


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
    450                 455                 460                 


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
465                 470                 475                 480 


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
                485                 490                 495     


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
            500                 505                 510         


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
        515                 520                 525             


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
    530                 535                 540                 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555 


<210>  413
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2280 Activatable Proprotein construct

<400>  413

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Pro Leu Gly Leu Ala Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Glu Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile 
        355                 360                 365             


Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    370                 375                 380                 


Ser Gly Gly Ala Glu Leu Cys Asp Asp Lys Pro Pro Glu Ile Pro His 
385                 390                 395                 400 


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
                405                 410                 415     


Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met 
            420                 425                 430         


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
        435                 440                 445             


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
    450                 455                 460                 


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
465                 470                 475                 480 


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
                485                 490                 495     


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
            500                 505                 510         


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
        515                 520                 525             


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
    530                 535                 540                 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 


<210>  414
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2281 Activatable Proprotein construct

<400>  414

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Glu Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Ile 
        355                 360                 365             


Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    370                 375                 380                 


Ser Gly Gly Ala Glu Leu Cys Asp Asp Lys Pro Pro Glu Ile Pro His 
385                 390                 395                 400 


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
                405                 410                 415     


Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met 
            420                 425                 430         


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
        435                 440                 445             


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
    450                 455                 460                 


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
465                 470                 475                 480 


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
                485                 490                 495     


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
            500                 505                 510         


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
        515                 520                 525             


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
    530                 535                 540                 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 


<210>  415
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2282 Activatable Proprotein construct

<400>  415

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Glu Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        355                 360                 365             


Ile Ser Thr Leu Thr Gly Gly Ser Pro Leu Gly Leu Ala Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Ala Glu Leu Cys Asp Asp Lys Pro Pro Glu Ile Pro His 
385                 390                 395                 400 


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
                405                 410                 415     


Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met 
            420                 425                 430         


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
        435                 440                 445             


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
    450                 455                 460                 


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
465                 470                 475                 480 


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
                485                 490                 495     


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
            500                 505                 510         


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
        515                 520                 525             


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
    530                 535                 540                 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 


<210>  416
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2283 Activatable Proprotein construct

<400>  416

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Glu Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        355                 360                 365             


Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    370                 375                 380                 


Ser Gly Gly Ala Glu Leu Cys Asp Asp Lys Pro Pro Glu Ile Pro His 
385                 390                 395                 400 


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
                405                 410                 415     


Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met 
            420                 425                 430         


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
        435                 440                 445             


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
    450                 455                 460                 


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
465                 470                 475                 480 


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
                485                 490                 495     


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
            500                 505                 510         


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
        515                 520                 525             


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
    530                 535                 540                 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 


<210>  417
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2314 Activatable Proprotein construct

<400>  417

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        355                 360                 365             


Ile Ser Thr Leu Thr Gly Gly Ser Pro Leu Gly Leu Ala Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His 
385                 390                 395                 400 


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
                405                 410                 415     


Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met 
            420                 425                 430         


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
        435                 440                 445             


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
    450                 455                 460                 


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
465                 470                 475                 480 


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
                485                 490                 495     


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
            500                 505                 510         


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
        515                 520                 525             


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
    530                 535                 540                 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 


<210>  418
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2315 Activatable Proprotein construct

<400>  418

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        355                 360                 365             


Ile Ser Thr Leu Thr Gly Gly Ser Pro Leu Gly Leu Ala Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His 
385                 390                 395                 400 


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
                405                 410                 415     


Glu Cys Lys Arg Gly Phe Arg Arg Ile Ala Ser Gly Ser Leu Tyr Met 
            420                 425                 430         


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
        435                 440                 445             


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
    450                 455                 460                 


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
465                 470                 475                 480 


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
                485                 490                 495     


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
            500                 505                 510         


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
        515                 520                 525             


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
    530                 535                 540                 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 


<210>  419
<211>  554
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2316 Activatable Proprotein construct

<400>  419

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
                245                 250                 255     


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            260                 265                 270         


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        275                 280                 285             


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    290                 295                 300                 


Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn Phe His Leu 
305                 310                 315                 320 


Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu Leu 
                325                 330                 335     


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            340                 345                 350         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser Thr 
        355                 360                 365             


Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    370                 375                 380                 


Ser Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His 
385                 390                 395                 400 


Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys 
                405                 410                 415     


Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met 
            420                 425                 430         


Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln 
        435                 440                 445             


Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln 
    450                 455                 460                 


Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met 
465                 470                 475                 480 


Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro 
                485                 490                 495     


Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly 
            500                 505                 510         


Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg 
        515                 520                 525             


Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp 
    530                 535                 540                 


Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 


<210>  420
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2236 cleaved protein construct

<400>  420

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser Pro Leu Gly 
225                 230                 235             


<210>  421
<211>  317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2236 cleaved protein construct

<400>  421

Leu Ala Gly Gly Gly Ser Gly Gly Ser Thr Lys Lys Thr Gln Leu Gln 
1               5                   10                  15      


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
            20                  25                  30          


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
        35                  40                  45              


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
    50                  55                  60                  


Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn 
65                  70                  75                  80  


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val 
                85                  90                  95      


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
            100                 105                 110         


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser 
        115                 120                 125             


Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gly Gly Ala Glu Leu Cys Asp Asp Ala Pro Pro Glu 
145                 150                 155                 160 


Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met 
                165                 170                 175     


Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser 
            180                 185                 190         


Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn 
        195                 200                 205             


Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val 
    210                 215                 220                 


Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln 
225                 230                 235                 240 


Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg 
                245                 250                 255     


Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe 
            260                 265                 270         


Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala 
        275                 280                 285             


Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys 
    290                 295                 300                 


Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
305                 310                 315         


<210>  422
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2236 cleaved protein construct

<400>  422

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser Pro Leu Gly Leu Ala 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu 
                245                 250                 255     


His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr 
            260                 265                 270         


Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro 
        275                 280                 285             


Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu 
    290                 295                 300                 


Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His 
305                 310                 315                 320 


Leu Arg Pro Arg Asp Leu Ile Ser Arg Ile Asn Val Ile Val Leu Glu 
                325                 330                 335     


Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr 
            340                 345                 350         


Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser Gln Ser 
        355                 360                 365             


Ile Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    370                 375                 380                 


Gly Ser Gly Gly Ala Glu Leu Cys Asp Asp Ala Pro Pro Glu Ile Pro 
385                 390                 395                 400 


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
                405                 410                 415     


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
            420                 425                 430         


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
        435                 440                 445             


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
    450                 455                 460                 


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
465                 470                 475                 480 


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
                485                 490                 495     


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
            500                 505                 510         


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
        515                 520                 525             


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
    530                 535                 540                 


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555 


<210>  423
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2236 cleaved protein construct

<400>  423

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser Pro Leu Gly 
225                 230                 235             


<210>  424
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2236 cleaved protein construct

<400>  424

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Ser Pro Leu Gly 
225                 230                 235             


<210>  425
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2012 cleaved protein construct

<400>  425

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Pro Leu Gly 
225                 230                 235         


<210>  426
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2012 cleaved protein construct

<400>  426

Leu Ala Gly Gly Gly Ser Ala Ala Ala Ser Ser Ser Thr Lys Lys Thr 
1               5                   10                  15      


Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn 
            20                  25                  30          


Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe 
        35                  40                  45              


Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys 
    50                  55                  60                  


Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro 
65                  70                  75                  80  


Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
                85                  90                  95      


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
            100                 105                 110         


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
        115                 120                 125             


Thr Phe Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Pro Leu Gly 
145             


<210>  427
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2012 cleaved protein construct

<400>  427

Leu Ala Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
1               5                   10                  15      


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
            20                  25                  30          


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu 
        35                  40                  45              


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
    50                  55                  60                  


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
65                  70                  75                  80  


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
                85                  90                  95      


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
            100                 105                 110         


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
        115                 120                 125             


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
    130                 135                 140                 


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
145                 150                 155                 160 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170         


<210>  428
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2012 cleaved protein construct

<400>  428

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Pro Leu Gly 
225                 230                 235         


<210>  429
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2012 cleaved protein construct

<400>  429

Leu Ala Gly Gly Gly Ser Ala Ala Ala Ser Ser Ser Thr Lys Lys Thr 
1               5                   10                  15      


Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn 
            20                  25                  30          


Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe 
        35                  40                  45              


Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys 
    50                  55                  60                  


Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro 
65                  70                  75                  80  


Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
                85                  90                  95      


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
            100                 105                 110         


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
        115                 120                 125             


Thr Phe Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Pro Leu Gly 
145             


<210>  430
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2012 cleaved protein construct

<400>  430

Leu Ala Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
1               5                   10                  15      


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
            20                  25                  30          


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu 
        35                  40                  45              


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
    50                  55                  60                  


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
65                  70                  75                  80  


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
                85                  90                  95      


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
            100                 105                 110         


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
        115                 120                 125             


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
    130                 135                 140                 


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
145                 150                 155                 160 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170         


<210>  431
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2012 cleaved protein construct

<400>  431

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Pro Leu Gly Leu Ala Gly 
225                 230                 235                 240 


Gly Gly Ser Ala Ala Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
                245                 250                 255     


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
            260                 265                 270         


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
        275                 280                 285             


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
    290                 295                 300                 


Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn 
305                 310                 315                 320 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
                325                 330                 335     


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
            340                 345                 350         


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser 
        355                 360                 365             


Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Pro Leu 
    370                 375                 380                 


Gly Leu Ala Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu 
385                 390                 395                 400 


Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met 
                405                 410                 415     


Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser 
            420                 425                 430         


Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn 
        435                 440                 445             


Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val 
    450                 455                 460                 


Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln 
465                 470                 475                 480 


Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg 
                485                 490                 495     


Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe 
            500                 505                 510         


Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala 
        515                 520                 525             


Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys 
    530                 535                 540                 


Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555         


<210>  432
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2012 cleaved protein construct

<400>  432

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Pro Leu Gly Leu Ala Gly 
225                 230                 235                 240 


Gly Gly Ser Ala Ala Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
                245                 250                 255     


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
            260                 265                 270         


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
        275                 280                 285             


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
    290                 295                 300                 


Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn 
305                 310                 315                 320 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
                325                 330                 335     


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
            340                 345                 350         


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser 
        355                 360                 365             


Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Pro Leu 
    370                 375                 380                 


Gly 
385 


<210>  433
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2012 cleaved protein construct

<400>  433

Leu Ala Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
1               5                   10                  15      


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
            20                  25                  30          


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu 
        35                  40                  45              


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
    50                  55                  60                  


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
65                  70                  75                  80  


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
                85                  90                  95      


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
            100                 105                 110         


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
        115                 120                 125             


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
    130                 135                 140                 


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
145                 150                 155                 160 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170         


<210>  434
<211>  557
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2012 cleaved protein construct

<400>  434

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Pro Leu Gly Leu Ala Gly 
225                 230                 235                 240 


Gly Gly Ser Ala Ala Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
                245                 250                 255     


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
            260                 265                 270         


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
        275                 280                 285             


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
    290                 295                 300                 


Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn 
305                 310                 315                 320 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
                325                 330                 335     


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
            340                 345                 350         


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser 
        355                 360                 365             


Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Pro Leu 
    370                 375                 380                 


Gly Leu Ala Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu 
385                 390                 395                 400 


Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met 
                405                 410                 415     


Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser 
            420                 425                 430         


Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn 
        435                 440                 445             


Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val 
    450                 455                 460                 


Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln 
465                 470                 475                 480 


Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg 
                485                 490                 495     


Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe 
            500                 505                 510         


Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala 
        515                 520                 525             


Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys 
    530                 535                 540                 


Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
545                 550                 555         


<210>  435
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2012 cleaved protein construct

<400>  435

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Pro Leu Gly 
225                 230                 235         


<210>  436
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2012 cleaved protein construct

<400>  436

Leu Ala Gly Gly Gly Ser Ala Ala Ala Ser Ser Ser Thr Lys Lys Thr 
1               5                   10                  15      


Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn 
            20                  25                  30          


Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe 
        35                  40                  45              


Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys 
    50                  55                  60                  


Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro 
65                  70                  75                  80  


Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
                85                  90                  95      


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
            100                 105                 110         


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
        115                 120                 125             


Thr Phe Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Pro Leu Gly 
145             


<210>  437
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2012 cleaved protein construct

<400>  437

Leu Ala Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
1               5                   10                  15      


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
            20                  25                  30          


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu 
        35                  40                  45              


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
    50                  55                  60                  


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
65                  70                  75                  80  


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
                85                  90                  95      


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
            100                 105                 110         


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
        115                 120                 125             


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
    130                 135                 140                 


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
145                 150                 155                 160 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170         


<210>  438
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2012 cleaved protein construct

<400>  438

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Pro Leu Gly 
225                 230                 235         


<210>  439
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2012 cleaved protein construct

<400>  439

Leu Ala Gly Gly Gly Ser Ala Ala Ala Ser Ser Ser Thr Lys Lys Thr 
1               5                   10                  15      


Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn 
            20                  25                  30          


Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe 
        35                  40                  45              


Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys 
    50                  55                  60                  


Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro 
65                  70                  75                  80  


Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
                85                  90                  95      


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
            100                 105                 110         


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
        115                 120                 125             


Thr Phe Ser Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly 
    130                 135                 140                 


Ser Pro Leu Gly Leu Ala Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp 
145                 150                 155                 160 


Pro Pro Glu Ile Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu 
                165                 170                 175     


Gly Thr Met Leu Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys 
            180                 185                 190         


Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser 
        195                 200                 205             


Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr 
    210                 215                 220                 


Lys Gln Val Thr Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr 
225                 230                 235                 240 


Glu Met Gln Ser Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly 
                245                 250                 255     


His Cys Arg Glu Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile 
            260                 265                 270         


Tyr His Phe Val Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly 
        275                 280                 285             


Tyr Arg Ala Leu His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr 
    290                 295                 300                 


His Gly Lys Thr Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
305                 310                 315                 320 


<210>  440
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2012 cleaved protein construct

<400>  440

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Ser Pro Leu Gly Leu Ala Gly 
225                 230                 235                 240 


Gly Gly Ser Ala Ala Ala Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln 
                245                 250                 255     


Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn 
            260                 265                 270         


Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr 
        275                 280                 285             


Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu 
    290                 295                 300                 


Glu Leu Lys Pro Leu Glu Glu Ala Leu Asn Leu Ala Pro Ser Lys Asn 
305                 310                 315                 320 


Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val 
                325                 330                 335     


Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp 
            340                 345                 350         


Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Ser 
        355                 360                 365             


Gln Ser Thr Ile Ser Thr Leu Thr Gly Gly Ser Gly Gly Ser Pro Leu 
    370                 375                 380                 


Gly 
385 


<210>  441
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - P2012 cleaved protein construct

<400>  441

Leu Ala Gly Gly Gly Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile 
1               5                   10                  15      


Pro His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu 
            20                  25                  30          


Asn Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu 
        35                  40                  45              


Tyr Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln 
    50                  55                  60                  


Cys Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr 
65                  70                  75                  80  


Pro Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser 
                85                  90                  95      


Pro Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu 
            100                 105                 110         


Pro Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val 
        115                 120                 125             


Val Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu 
    130                 135                 140                 


His Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr 
145                 150                 155                 160 


Arg Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu 
                165                 170         


