                         SEQUENCE LISTING

<110>  Agency for Science, Technology and Research
       National University of Singapore
 
<120>  Treatment/Prevention of Disease by LINC Complex Inhibition

<130>  2001080

<150>  SG 10201906637U
<151>  2019-07-17

<160>  129   

<170>  PatentIn version 3.5

<210>  1
<211>  15424
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid pAdDeltaF6

<400>  1
tcgacggtat cgataagctt gatatcgaat tcctgcagcc cgggggatcc actagttcta       60

gagcggccgc caccgcggtg gagctccagc ttttgttccc tttagtgagg gttaatttcg      120

agcttggcgt aatcatggtc atagctgttt cctgtgtgaa attgttatcc gctcacaatt      180

ccacacaaca tacgagccgg aagcataaag tgtaaagcct ggggtgccta atgagtgagc      240

taactcacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc      300

cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct      360

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca      420

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac      480

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt      540

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg      600

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc      660

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc      720

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc      780

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac      840

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt      900

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct      960

aactacggct acactagaag gacagtattt ggtatctgcg ctctgctgaa gccagttacc     1020

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt     1080

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg     1140

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc     1200

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa     1260

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag     1320

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg     1380

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga     1440

gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag     1500

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa     1560

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc     1620

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca     1680

aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg     1740

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat     1800

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc     1860

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg     1920

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg     1980

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt     2040

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca     2100

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata     2160

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac     2220

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa     2280

gtgccacctg acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt     2340

atcacgaggc cctttcgtct tcaagaattc tcatgtttga cagcttatca tcgataagct     2400

ttaatgcggt agtttatcac agttaaattg ctaacgcagt caggcaccgt gtatgaaatc     2460

taacaatgcg ctcatcgtca tcctcggcac cgtcaccctg gatgctgtag gcataggctt     2520

ggttatgccg gtactgccgg gcctcttgcg ggatatcgtc cattccgaca gcatcgccag     2580

tcactatggc gtgctgctag cgctatatgc gttgatgcaa tttctatgcg cacccgttct     2640

cggagcactg tccgaccgct ttggccgccg cccagtcctg ctcgcttcgc tacttggagc     2700

cactatcgac tacgcgatca tggcgaccac acccgtcctg tggatccggc gcacaccaaa     2760

aacgtcactt ttgccacatc cgtcgcttac atgtgttccg ccacacttgc aacatcacac     2820

ttccgccaca ctactacgtc acccgccccg ttcccacgcc ccgcgccacg tcacaaactc     2880

caccccctca ttatcatatt ggcttcaatc caaaataaat catcaataat ataccttatt     2940

ttggattgaa gccaatatga taatgagggg gtggagtttg tgacgtggcg cggggcgtgg     3000

gaacggggcg ggtgacgtag gttttagggc ggagtaactt gtatgtgttg ggaattgtag     3060

ttttcttaaa atgggaagtt acgtaacgtg ggaaaacgga agtgacgatt tgaggaagtt     3120

gtgggttttt tggctttcgt ttctgggcgt aggttcgcgt gcggttttct gggtgttttt     3180

tgtggacttt aaccgttacg tcatttttta gtcctatata tactcgctct gcacttggcc     3240

cttttttaca ctgtgactga ttgagctggt gccgtgtcga gtggtgtttt tttaataggt     3300

tttctttttt actggtaagg ctgactgtta ggctgccgct gtgaagcgct gtatgttgtt     3360

ctggagcggg agggtgctat tttgcctagg caggagggtt tttcaggtgt ttatgtgttt     3420

ttctctccta ttaattttgt tatacctcct atgggggctg taatgttgtc tctacgcctg     3480

cgggtatgta ttcccccggg ctatttcggt cgctttttag cactgaccga tgaatcaacc     3540

tgatgtgttt accgagtctt acattatgac tccggacatg accgaggagc tgtcggtggt     3600

gctttttaat cacggtgacc agttttttta cggtcacgcc ggcatggccg tagtccgtct     3660

tatgcttata agggttgttt ttcctgttgt aagacaggct tctaatgttt aaatgttttt     3720

ttgttatttt attttgtgtt tatgcagaaa cccgcagaca tgtttgagag aaaaatggtg     3780

tctttttctg tggtggttcc ggagcttacc tgcctttatc tgcatgagca tgactacgat     3840

gtgctttctt ttttgcgcga ggctttgcct gattttttga gcagcacctt gcattttata     3900

tcgccgccca tgcaacaaag cttacatcgg ggctacgctg gttagcatag ctccgagtat     3960

gcgtgtcata atcagtgtgg gttcttttgt caaggttcct ggcggggaag tggccgcgct     4020

ggtccgtgca gacctgcacg attatgttca gctggccctg cgaagggacc tacgggatcg     4080

cggtattttt gttaatgttc cgcttttgaa tcttatacag gtctgtgagg aacctgaatt     4140

tttgcaatca tgattcgctg cttgaggctg aaggtggagg gcgctctgga gcagattttt     4200

acaatggccg gacttaatat tcgggatttg cttagagata tattgagaag gtggcgagat     4260

gagaattatt tgggcatggt tgaaggtgct ggaatgttta tagaggagat tcaccctgaa     4320

gggtttagcc tttacgtcca cttggacgtg agggccgttt gccttttgga agccattgtg     4380

caacatctta caaatgccat tatctgttct ttggctgtag agtttgacca cgccaccgga     4440

ggggagcgcg ttcacttaat agatcttcat tttgaggttt tggataatct tttggaataa     4500

aaaaaaaaac atggttcttc cagctcttcc cgctcctccc gtgtgtgact cgcagaacga     4560

atgtgtaggt tggctgggtg tggcttattc tgcggtggtg gatgttatca gggcagcggc     4620

gcatgaagga gtttacatag aacccgaagc cagggggcgc ctggatgctt tgagagagtg     4680

gatatactac aactactaca cagagcgatc taagcggcga gaccggagac gcagatctgt     4740

ttgtcacgcc cgcacctggt tttgcttcag gaaatatgac tacgtccggc gttccatttg     4800

gcatgacact acgaccaaca cgatctcggt tgtctcggcg cactccgtac agtagggatc     4860

gtctacctcc ttttgagaca gaaacccgcg ctaccatact ggaggatcat ccgctgctgc     4920

ccgaatgtaa cactttgaca atgcacaacg tgagttacgt gcgaggtctt ccctgcagtg     4980

tgggatttac gctgattcag gaatgggttg ttccctggga tatggttcta acgcgggagg     5040

agcttgtaat cctgaggaag tgtatgcacg tgtgcctgtg ttgtgccaac attgatatca     5100

tgacgagcat gatgatccat ggttacgagt cctgggctct ccactgtcat tgttccagtc     5160

ccggttccct gcagtgtata gccggcgggc aggttttggc cagctggttt aggatggtgg     5220

tggatggcgc catgtttaat cagaggttta tatggtaccg ggaggtggtg aattacaaca     5280

tgccaaaaga ggtaatgttt atgtccagcg tgtttatgag gggtcgccac ttaatctacc     5340

tgcgcttgtg gtatgatggc cacgtgggtt ctgtggtccc cgccatgagc tttggataca     5400

gcgccttgca ctgtgggatt ttgaacaata ttgtggtgct gtgctgcagt tactgtgctg     5460

atttaagtga gatcagggtg cgctgctgtg cccggaggac aaggcgcctt atgctgcggg     5520

cggtgcgaat catcgctgag gagaccactg ccatgttgta ttcctgcagg acggagcggc     5580

ggcggcagca gtttattcgc gcgctgctgc agcaccaccg ccctatcctg atgcacgatt     5640

atgactctac ccccatgtag gcgtggactt ctccttcgcc gcccgttaag caaccgcaag     5700

ttggacagca gcctgtggct cagcagctgg acagcgacat gaacttaagt gagctgcccg     5760

gggagtttat taatatcact gatgagcgtt tggctcgaca ggaaaccgtg tggaatataa     5820

cacctaagaa tatgtctgtt acccatgata tgatgctttt taaggccagc cggggagaaa     5880

ggactgtgta ctctgtgtgt tgggagggag gtggcaggtt gaatactagg gttctgtgag     5940

tttgattaag gtacggtgat ctgtataagc tatgtggtgg tggggctata ctactgaatg     6000

aaaaatgact tgaaattttc tgcaattgaa aaataaacac gttgaaacat aacacaaacg     6060

attctttatt cttgggcaat gtatgaaaaa gtgtaagagg atgtggcaaa tatttcatta     6120

atgtagttgt ggccagacca gtcccatgaa aatgacatag agtatgcact tggagttgtg     6180

tctcctgttt cctgtgtacc gtttagtgta atggttagtg ttacaggttt agttttgtct     6240

ccgtttaagt aaacttgact gacaatgtta cttttggcag ttttaccgtg agattttgga     6300

taagctgata ggttaggcat aaatccaaca gcgtttgtat aggctgtgcc ttcagtaaga     6360

tctccatttc taaagttcca atattctggg tccaggaagg aattgtttag tagcactcca     6420

ttttcgtcaa atcttataat aagatgagca ctttgaactg ttccagatat tggagccaaa     6480

ctgcctttaa cagccaaaac tgaaactgta gcaagtattt gactgccaca ttttgttaag     6540

accaaagtga gtttagcatc tttctctgca tttagtctac agttaggaga tggagctggt     6600

gtggtccaca aagttagctt atcattattt ttgtttccta ctgtaatggc acctgtgctg     6660

tcaaaactaa ggccagttcc tagtttagga accatagcct tgtttgaatc aaattctagg     6720

ccatggccaa tttttgtttt gaggggattt gtgtttggtg cattaggtga accaaattca     6780

agcccatctc ctgcattaat ggctatggct gtagcgtcaa acatcaaccc cttggcagtg     6840

cttaggttaa cctcaagctt tttggaattg tttgaagctg taaacaagta aaggcctttg     6900

ttgtagttaa tatccaagtt gtgggctgag tttataaaaa gagggccctg tcctagtctt     6960

agatttagtt ggttttgagc atcaaacgga taactaacat caagtataag gcgtctgttt     7020

tgagaatcaa tccttagtcc tcctgctaca ttaagttgca tattgccttg tgaatcaaaa     7080

cccaaggctc cagtaacttt agtttgcaag gaagtattat taatagtcac acctggacca     7140

gttgctacgg tcaaagtgtt taggtcgtct gttacatgca aaggagcccc gtactttagt     7200

cctagttttc cattttgtgt ataaatgggc tctttcaagt caatgcccaa gctaccagtg     7260

gcagtagtta gagggggtga ggcagtgata gtaagggtac tgctatcggt ggtggtgagg     7320

gggcctgatg tttgcagggc tagctttcct tctgacactg tgaggggtcc ttgggtggca     7380

atgctaagtt tggagtcgtg cacggttagc ggggcctgtg attgcatggt gagtgtgttg     7440

cccgcgacca ttagaggtgc ggcggcagcc acagttaggg cttctgaggt aactgtgagg     7500

ggtgcagata tttccaggtt tatgtttgac ttggtttttt tgagaggtgg gctcacagtg     7560

gttacatttt gggaggtaag gttgccggcc tcgtccagag agaggccgtt gcccattttg     7620

agcgcaagca tgccattgga ggtaactaga ggttcggata ggcgcaaaga gagtacccca     7680

gggggactct cttgaaaccc attgggggat acaaagggag gagtaagaaa aggcacagtt     7740

ggaggaccgg tttccgtgtc atatggatac acggggttga aggtatcttc agacggtctt     7800

gcgcgcttca tctgcaacaa catgaagata gtgggtgcgg atggacagga acaggaggaa     7860

actgacattc catttagatt gtggagaaag tttgcagcca ggaggaagct gcaataccag     7920

agctgggagg agggcaagga ggtgctgctg aataaactgg acagaaattt gctaactgat     7980

tttaagtaag tgatgcttta ttattttttt ttattagtta aagggaataa gatccccggg     8040

tactctagtt aattaactag aggatcttga tgtaatccaa ggttaggaca gttgcaaatc     8100

acagtgagaa cacagggtcc cctgtcccgc tcaactagca gggggcgctg ggtaaactcc     8160

cgaatcaggc tacgggcaag ctctccctgg gcggtaagcc ggacgccgtg cgccgggccc     8220

tcgatatgat cctcgggcaa ttcaaagtag caaaactcac cggagtcgcg ggcaaagcac     8280

ttgtggcggc gacagtggac caggtgtttc aggcgcagtt gctctgcctc tccacttaac     8340

attcagtcgt agccgtccgc cgagtccttt accgcgtcaa agttaggaat aaattgatcc     8400

ggatagtggc cgggaggtcc cgagaagggg ttaaagtaga ccgatggcac aaactcctca     8460

ataaattgca gagttccaat gcctccagag cgcggctcag aggacgaggt ctgcagagtt     8520

aggattgcct gacgaggcgt gaatgaagga cggccggcgc cgccgatctg aaatgtcccg     8580

tccggacgga gaccaagcga ggagctcacc gactcgtcgt tgagctgaat acctcgccct     8640

ctgattgtca ggtgagttat accctgcccg ggcgaccgca ccctgtgacg aaagccgccc     8700

gcaagctgcg cccctgagtt agtcatctga acttcggcct gggcgtctct gggaagtacc     8760

acagtggtgg gagcgggact ttcctggtac accagggcag cgggccaact acggggatta     8820

aggttattac gaggtgtggt ggtaatagcc gcctgttcca agagaattcg gtttcggtgg     8880

gcgcggattc cgttgacccg ggatatcatg tggggtcccg cgctcatgta gtttattcgg     8940

gttgagtagt cttgggcagc tccagccgca agtcccattt gtggctggta actccacatg     9000

tagggcgtgg gaatttcctt gctcataatg gcgctgacga caggtgctgg cgccgggtgt     9060

ggccgctgga gatgacgtag ttttcgcgct taaatttgag aaagggcgcg aaactagtcc     9120

ttaagagtca gcgcgcagta tttactgaag agagcctccg cgtcttccag cgtgcgccga     9180

agctgatctt cgcttttgtg atacaggcag ctgcgggtga gggatcgcag agacctgttt     9240

tttattttca gctcttgttc ttggcccctg ctctgttgaa atatagcata cagagtggga     9300

aaaatcctgt ttctaagctc gcgggtcgat acgggttcgt tgggcgccag acgcagcgct     9360

cctcctcctg ctgctgccgc cgctgtggat ttcttgggct ttgtcagagt cttgctatcc     9420

ggtcgccttt gcttctgtgt ggccgctgct gttgctgccg ctgccgctgc cgccggtgca     9480

gtatgggctg tagagatgac ggtagtaatg caggatgtta cgggggaagg ccacgccgtg     9540

atggtagaga agaaagcggc gggcgaagga gatgttgccc ccacagtctt gcaagcaagc     9600

aactatggcg ttcttgtgcc cgcgccatga gcggtagcct tggcgctgtt gttgctcttg     9660

ggctaacggc ggcggctgct tggacttacc ggccctggtt ccagtggtgt cccatctacg     9720

gttgggtcgg cgaacgggca gtgccggcgg cgcctgagga gcggaggttg tagccatgct     9780

ggaaccggtt gccgatttct ggggcgccgg cgaggggaat gcgaccgagg gtgacggtgt     9840

ttcgtctgac acctcttcga cctcggaagc ttcctcgtct aggctctccc agtcttccat     9900

catgtcctcc tcctcctcgt ccaaaacctc ctctgcctga ctgtcccagt attcctcctc     9960

gtccgtgggt ggcggcggca gctgcagctt ctttttgggt gccatcctgg gaagcaaggg    10020

cccgcggctg ctgctgatag ggctgcggcg gcggggggat tgggttgagc tcctcgccgg    10080

actgggggtc caagtaaacc ccccgtccct ttcgtagcag aaactcttgg cgggctttgt    10140

tgatggcttg caattggcca agaatgtggc cctgggtaat gacgcaggcg gtaagctccg    10200

catttggcgg gcgggattgg tcttcgtaga acctaatctc gtgggcgtgg tagtcctcag    10260

gtacaaattt gcgaaggtaa gccgacgtcc acagccccgg agtgagtttc aaccccggag    10320

ccgcggactt ttcgtcaggc gagggaccct gcagctcaaa ggtaccgata atttgacttt    10380

cgttaagcag ctgcgaattg caaaccaggg agcggtgcgg ggtgcatagg ttgcagcgac    10440

agtgacactc cagtagaccg tcaccgctca cgtcttccat tatgtcagag tggtaggcaa    10500

ggtagttggc tagctgcaga aggtagcagt ggccccaaag cggcggaggg cattcgcggt    10560

acttaatggg cacaaagtcg ctaggaagtg cacagcaggt ggcgggcaag attcctgagc    10620

gctctaggat aaagttccta aagttctgca acatgctttg actggtgaag tctggcagac    10680

cctgttgcag ggttttaagc aggcgttcgg ggaaaatgat gtccgccagg tgcgcggcca    10740

cggagcgctc gttgaaggcc gtccataggt ccttcaagtt ttgctttagc agtttctgca    10800

gctccttgag gttgcactcc tccaagcact gctgccaaac gcccatggcc gtctgccagg    10860

tgtagcatag aaataagtaa acgcagtcgc ggacgtagtc gcggcgcgcc tcgcccttga    10920

gcgtggaatg aagcacgttt tgcccaaggc ggttttcgtg caaaattcca aggtaggaga    10980

ccaggttgca gagctccacg ttggagatct tgcaggcctg gcgtacgtag ccctgtcgaa    11040

aggtgtagtg caatgtttcc tctagcttgc gctgcatctc cgggtcagca aagaaccgct    11100

gcatgcactc aagctccacg gtaacgagca ctgcggccat cattagtttg cgtcgctcct    11160

ccaagtcggc aggctcgcgc gtttgaagcc agcgcgctag ctgctcgtcg ccaactgcgg    11220

gtaggccctc ctctgtttgt tcttgcaaat ttgcatccct ctccaggggc tgcgcacggc    11280

gcacgatcag ctcactcatg actgtgctca tgaccttggg gggtaggtta agtgccgggt    11340

aggcaaagtg ggtgacctcg atgctgcgtt ttagtacggc taggcgcgcg ttgtcaccct    11400

cgagttccac caacactcca gagtgacttt cattttcgct gttttcctgt tgcagagcgt    11460

ttgccgcgcg cttctcgtcg cgtccaagac cctcaaagat ttttggcact tcgttgagcg    11520

aggcgatatc aggtatgaca gcgccctgcc gcaaggccag ctgcttgtcc gctcggctgc    11580

ggttggcacg gcaggatagg ggtatcttgc agttttggaa aaagatgtga taggtggcaa    11640

gcacctctgg cacggcaaat acggggtaga agttgaggcg cgggttgggc tcgcatgtgc    11700

cgttttcttg gcgtttgggg ggtacgcgcg gtgagaatag gtggcgttcg taggcaaggc    11760

tgacatccgc tatggcgagg ggcacatcgc tgcgctcttg caacgcgtcg cagataatgg    11820

cgcactggcg ctgcagatgc ttcaacagca cgtcgtctcc cacatctagg tagtcgccat    11880

gcctttcgtc cccccgcccg acttgttcct cgtttgcctc tgcgttgtcc tggtcttgct    11940

ttttatcctc tgttggtact gagcggtcct cgtcgtcttc gcttacaaaa cctgggtcct    12000

gctcgataat cacttcctcc tcctcaagcg ggggtgcctc gacggggaag gtggtaggcg    12060

cgttggcggc atcggtggag gcggtggtgg cgaactcaga gggggcggtt aggctgtcct    12120

tcttctcgac tgactccatg atctttttct gcctatagga gaaggaaatg gccagtcggg    12180

aagaggagca gcgcgaaacc acccccgagc gcggacgcgg tgcggcgcga cgtcccccaa    12240

ccatggagga cgtgtcgtcc ccgtccccgt cgccgccgcc tccccgggcg cccccaaaaa    12300

agcggatgag gcggcgtatc gagtccgagg acgaggaaga ctcatcacaa gacgcgctgg    12360

tgccgcgcac acccagcccg cggccatcga cctcggcggc ggatttggcc attgcgccca    12420

agaagaaaaa gaagcgccct tctcccaagc ccgagcgccc gccatcacca gaggtaatcg    12480

tggacagcga ggaagaaaga gaagatgtgg cgctacaaat ggtgggtttc agcaacccac    12540

cggtgctaat caagcatggc aaaggaggta agcgcacagt gcggcggctg aatgaagacg    12600

acccagtggc gcgtggtatg cggacgcaag aggaagagga agagcccagc gaagcggaaa    12660

gtgaaattac ggtgatgaac ccgctgagtg tgccgatcgt gtctgcgtgg gagaagggca    12720

tggaggctgc gcgcgcgctg atggacaagt accacgtgga taacgatcta aaggcgaact    12780

tcaaactact gcctgaccaa gtggaagctc tggcggccgt atgcaagacc tggctgaacg    12840

aggagcaccg cgggttgcag ctgaccttca ccagcaacaa gacctttgtg acgatgatgg    12900

ggcgattcct gcaggcgtac ctgcagtcgt ttgcagaggt gacctacaag catcacgagc    12960

ccacgggctg cgcgttgtgg ctgcaccgct gcgctgagat cgaaggcgag cttaagtgtc    13020

tacacggaag cattatgata aataaggagc acgtgattga aatggatgtg acgagcgaaa    13080

acgggcagcg cgcgctgaag gagcagtcta gcaaggccaa gatcgtgaag aaccggtggg    13140

gccgaaatgt ggtgcagatc tccaacaccg acgcaaggtg ctgcgtgcac gacgcggcct    13200

gtccggccaa tcagttttcc ggcaagtctt gcggcatgtt cttctctgaa ggcgcaaagg    13260

ctcaggtggc ttttaagcag atcaaggctt ttatgcaggc gctgtatcct aacgcccaga    13320

ccgggcacgg tcaccttttg atgccactac ggtgcgagtg caactcaaag cctgggcacg    13380

cgcccttttt gggaaggcag ctaccaaagt tgactccgtt cgccctgagc aacgcggagg    13440

acctggacgc ggatctgatc tccgacaaga gcgtgctggc cagcgtgcac cacccggcgc    13500

tgatagtgtt ccagtgctgc aaccctgtgt atcgcaactc gcgcgcgcag ggcggaggcc    13560

ccaactgcga cttcaagata tcggcgcccg acctgctaaa cgcgttggtg atggtgcgca    13620

gcctgtggag tgaaaacttc accgagctgc cgcggatggt tgtgcctgag tttaagtgga    13680

gcactaaaca ccagtatcgc aacgtgtccc tgccagtggc gcatagcgat gcgcggcaga    13740

acccctttga tttttaaacg gcgcagacgg caagggtggg ggtaaataat cacccgagag    13800

tgtacaaata aaagcatttg cctttattga aagtgtctct agtacattat ttttacatgt    13860

ttttcaagtg acaaaaagaa gtggcgctcc taatctgcgc actgtggctg cggaagtagg    13920

gcgagtggcg ctccaggaag ctgtagagct gttcctggtt gcgacgcagg gtgggctgta    13980

cctggggact gttgagcatg gagttgggta ccccggtaat aaggttcatg gtggggttgt    14040

gatccatggg agtttggggc cagttggcaa aggcgtggag aaacatgcag cagaatagtc    14100

cacaggcggc cgagttgggc ccctgtacgc tttgggtgga cttttccagc gttatacagc    14160

ggtcggggga agaagcaatg gcgctacggc gcaggagtga ctcgtactca aactggtaaa    14220

cctgcttgag tcgctggtca gaaaagccaa agggctcaaa gaggtagcat gtttttgagt    14280

gcgggttcca ggcaaaggcc atccagtgta cgcccccagt ctcggtccga gactcgaacc    14340

gggggtcccg cgactcaacc cttggaaaat aaccctccgg ctacagggag cgagccactt    14400

aatgctttcg ctttccagcc taaccgctta cgctgcgcgc ggccagtggc caaaaaagct    14460

agcgcagcag ccgccgcgcc tggaaggaag ccaaaaggag cactcccccg ttgtctgacg    14520

tcgcacacct gggttcgaca cgcgggcggt aaccgcatgg atcacggcgg acggccggat    14580

acggggctcg aaccccggtc gtccgccatg atacccttgc gaatttatcc accagaccac    14640

ggaagagtgc ccgcttacag gctctccttt tgcacggtag agcgtcaacg attgcgcgcg    14700

cctgaccggc cagagcgtcc cgaccatgga gcactttttg ccgctgcgca acatctggaa    14760

ccgcgtccgc gactttccgc gcgcctccac caccgccgcc ggcatcacct ggatgtccag    14820

gtacatctac ggatatcatc gccttatgtt ggaagatctc gcccccggag ccccggccac    14880

cctacgctgg cccctctacc gccagccgcc gccgcacttt ttggtgggat accagtacct    14940

ggtgcggact tgcaacgact acgtatttga ctcgagggct tactcgcgtc tcaggtacac    15000

cgagctctcg cagccgggtc accagaccgt taactggtcc gttatggcca actgcactta    15060

caccatcaac acgggcgcat accaccgctt tgtggacatg gatgacttcc agtctaccct    15120

cacgcaggtg cagcaggcca tattagccga gcgcgttgtc gccgacctag ccctgcttca    15180

gccgatgagg ggcttcgggg tcacacgcat gggaggaaga gggcgccacc tacggccaaa    15240

ctccgccgcc gccgcagcga tagatgcaag agatgcagga caagaggaag gagaagaaga    15300

agtgccggta gaaaggctca tgcaagacta ctacaaagac ctgcgccgat gtcaaaacga    15360

agcctggggc atggccgacc gcctgcgcat tcagcaggcc ggacccaagg acatggtgct    15420

tctg                                                                 15424


<210>  2
<211>  7330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid pAAV2_9

<400>  2
gtcgacggta tcgggggagc tcgcagggtc tccattttga agcgggaggt ttgaacgcgc       60

agccgccatg ccggggtttt acgagattgt gattaaggtc cccagcgacc ttgacgagca      120

tctgcccggc atttctgaca gctttgtgaa ctgggtggcc gagaaggaat gggagttgcc      180

gccagattct gacatggatc tgaatctgat tgagcaggca cccctgaccg tggccgagaa      240

gctgcagcgc gactttctga cggaatggcg ccgtgtgagt aaggccccgg aggctctttt      300

ctttgtgcaa tttgagaagg gagagagcta cttccacatg cacgtgctcg tggaaaccac      360

cggggtgaaa tccatggttt tgggacgttt cctgagtcag attcgcgaaa aactgattca      420

gagaatttac cgcgggatcg agccgacttt gccaaactgg ttcgcggtca caaagaccag      480

aaatggcgcc ggaggcggga acaaggtggt ggatgagtgc tacatcccca attacttgct      540

ccccaaaacc cagcctgagc tccagtgggc gtggactaat atggaacagt atttaagcgc      600

ctgtttgaat ctcacggagc gtaaacggtt ggtggcgcag catctgacgc acgtgtcgca      660

gacgcaggag cagaacaaag agaatcagaa tcccaattct gatgcgccgg tgatcagatc      720

aaaaacttca gccaggtaca tggagctggt cgggtggctc gtggacaagg ggattacctc      780

ggagaagcag tggatccagg aggaccaggc ctcatacatc tccttcaatg cggcctccaa      840

ctcgcggtcc caaatcaagg ctgccttgga caatgcggga aagattatga gcctgactaa      900

aaccgccccc gactacctgg tgggccagca gcccgtggag gacatttcca gcaatcggat      960

ttataaaatt ttggaactaa acgggtacga tccccaatat gcggcttccg tctttctggg     1020

atgggccacg aaaaagttcg gcaagaggaa caccatctgg ctgtttgggc ctgcaactac     1080

cgggaagacc aacatcgcgg aggccatagc ccacactgtg cccttctacg ggtgcgtaaa     1140

ctggaccaat gagaactttc ccttcaacga ctgtgtcgac aagatggtga tctggtggga     1200

ggaggggaag atgaccgcca aggtcgtgga gtcggccaaa gccattctcg gaggaagcaa     1260

ggtgcgcgtg gaccagaaat gcaagtcctc ggcccagata gacccgactc ccgtgatcgt     1320

cacctccaac accaacatgt gcgccgtgat tgacgggaac tcaacgacct tcgaacacca     1380

gcagccgttg caagaccgga tgttcaaatt tgaactcacc cgccgtctgg atcatgactt     1440

tgggaaggtc accaagcagg aagtcaaaga ctttttccgg tgggcaaagg atcacgtggt     1500

tgaggtggag catgaattct acgtcaaaaa gggtggagcc aagaaaagac ccgcccccag     1560

tgacgcagat ataagtgagc ccaaacgggt gcgcgagtca gttgcgcagc catcgacgtc     1620

agacgcggaa gcttcgatca actacgcgga caggtaccaa aacaaatgtt ctcgtcacgt     1680

gggcatgaat ctgatgctgt ttccctgcag acaatgcgag agactgaatc agaattcaaa     1740

tatctgcttc actcacggtg tcaaagactg tttagagtgc tttcccgtgt cagaatctca     1800

acccgtttct gtcgtcaaaa aggcgtatca gaaactgtgc tacattcatc acatcatggg     1860

aaaggtgcca gacgcttgca ctgcttgcga cctggtcaat gtggacttgg atgactgtgt     1920

ttctgaacaa taaatgactt aaaccaggta tggctgccga tggttatctt ccagattggc     1980

tcgaggacaa ccttagtgaa ggaattcgcg agtggtgggc tttgaaacct ggagcccctc     2040

aacccaaggc aaatcaacaa catcaagaca acgctcgagg tcttgtgctt ccgggttaca     2100

aataccttgg acccggcaac ggactcgaca agggggagcc ggtcaacgca gcagacgcgg     2160

cggccctcga gcacgacaag gcctacgacc agcagctcaa ggccggagac aacccgtacc     2220

tcaagtacaa ccacgccgac gccgagttcc aggagcggct caaagaagat acgtcttttg     2280

ggggcaacct cgggcgagca gtcttccagg ccaaaaagag gcttcttgaa cctcttggtc     2340

tggttgagga agcggctaag acggctcctg gaaagaagag gcctgtagag cagtctcctc     2400

aggaaccgga ctcctccgcg ggtattggca aatcgggtgc acagcccgct aaaaagagac     2460

tcaatttcgg tcagactggc gacacagagt cagtcccaga ccctcaacca atcggagaac     2520

ctcccgcagc cccctcaggt gtgggatctc ttacaatggc ttcaggtggt ggcgcaccag     2580

tggcagacaa taacgaaggt gccgatggag tgggtagttc ctcgggaaat tggcattgcg     2640

attcccaatg gctgggggac agagtcatca ccaccagcac ccgaacctgg gccctgccca     2700

cctacaacaa tcacctctac aagcaaatct ccaacagcac atctggagga tcttcaaatg     2760

acaacgccta cttcggctac agcaccccct gggggtattt tgacttcaac agattccact     2820

gccacttctc accacgtgac tggcagcgac tcatcaacaa caactgggga ttccggccta     2880

agcgactcaa cttcaagctc ttcaacattc aggtcaaaga ggttacggac aacaatggag     2940

tcaagaccat cgccaataac cttaccagca cggtccaggt cttcacggac tcagactatc     3000

agctcccgta cgtgctcggg tcggctcacg agggctgcct cccgccgttc ccagcggacg     3060

ttttcatgat tcctcagtac gggtatctga cgcttaatga tggaagccag gccgtgggtc     3120

gttcgtcctt ttactgcctg gaatatttcc cgtcgcaaat gctaagaacg ggtaacaact     3180

tccagttcag ctacgagttt gagaacgtac ctttccatag cagctacgct cacagccaaa     3240

gcctggaccg actaatgaat ccactcatcg accaatactt gtactatctc tcaaagacta     3300

ttaacggttc tggacagaat caacaaacgc taaaattcag tgtggccgga cccagcaaca     3360

tggctgtcca gggaagaaac tacatacctg gacccagcta ccgacaacaa cgtgtctcaa     3420

ccactgtgac tcaaaacaac aacagcgaat ttgcttggcc tggagcttct tcttgggctc     3480

tcaatggacg taatagcttg atgaatcctg gacctgctat ggccagccac aaagaaggag     3540

aggaccgttt ctttcctttg tctggatctt taatttttgg caaacaagga actggaagag     3600

acaacgtgga tgcggacaaa gtcatgataa ccaacgaaga agaaattaaa actactaacc     3660

cggtagcaac ggagtcctat ggacaagtgg ccacaaacca ccagagtgcc caagcacagg     3720

cgcagaccgg ctgggttcaa aaccaaggaa tacttccggg tatggtttgg caggacagag     3780

atgtgtacct gcaaggaccc atttgggcca aaattcctca cacggacggc aactttcacc     3840

cttctccgct gatgggaggg tttggaatga agcacccgcc tcctcagatc ctcatcaaaa     3900

acacacctgt acctgcggat cctccaacgg ccttcaacaa ggacaagctg aactctttca     3960

tcacccagta ttctactggc caagtcagcg tggagatcga gtgggagctg cagaaggaaa     4020

acagcaagcg ctggaacccg gagatccagt acacttccaa ctattacaag tctaataatg     4080

ttgaatttgc tgttaatact gaaggtgtat atagtgaacc ccgccccatt ggcaccagat     4140

acctgactcg taatctgtaa ttgcttgtta atcaataaac cgtttaattc gtttcagttg     4200

aactttggtc tctgcgaagg gcgaattcgt ttaaacctgc aggactagag gtcctgtatt     4260

agaggtcacg tgagtgtttt gcgacatttt gcgacaccat gtggtcacgc tgggtattta     4320

agcccgagtg agcacgcagg gtctccattt tgaagcggga ggtttgaacg cgcagccgcc     4380

aagccgaatt ctgcagatat ccatcacact ggcggccgct cgactagagc ggccgccacc     4440

gcggtggagc tccagctttt gttcccttta gtgagggtta attgcgcgct tggcgtaatc     4500

atggtcatag ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg     4560

agccggaagc ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat     4620

tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg     4680

aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct     4740

cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc     4800

ggtaatacgg ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg     4860

ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg     4920

cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg     4980

actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac     5040

cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca     5100

tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt     5160

gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc     5220

caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag     5280

agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac     5340

tagaagaaca gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt     5400

tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa     5460

gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg     5520

gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa     5580

aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat     5640

atatgagtaa acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc     5700

gatctgtcta tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat     5760

acgggagggc ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc     5820

ggctccagat ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc     5880

tgcaacttta tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag     5940

ttcgccagtt aatagtttgc gcaacgttgt tgccattgct acaggcatcg tggtgtcacg     6000

ctcgtcgttt ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg     6060

atcccccatg ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag     6120

taagttggcc gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt     6180

catgccatcc gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga     6240

atagtgtatg cggcgaccga gttgctcttg cccggcgtca atacgggata ataccgcgcc     6300

acatagcaga actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc     6360

aaggatctta ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc     6420

ttcagcatct tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc     6480

cgcaaaaaag ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca     6540

atattattga agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat     6600

ttagaaaaat aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctaaatt     6660

gtaagcgtta atattttgtt aaaattcgcg ttaaattttt gttaaatcag ctcatttttt     6720

aaccaatagg ccgaaatcgg caaaatccct tataaatcaa aagaatagac cgagataggg     6780

ttgagtgttg ttccagtttg gaacaagagt ccactattaa agaacgtgga ctccaacgtc     6840

aaagggcgaa aaaccgtcta tcagggcgat ggcccactac gtgaaccatc accctaatca     6900

agttttttgg ggtcgaggtg ccgtaaagca ctaaatcgga accctaaagg gagcccccga     6960

tttagagctt gacggggaaa gccggcgaac gtggcgagaa aggaagggaa gaaagcgaaa     7020

ggagcgggcg ctagggcgct ggcaagtgta gcggtcacgc tgcgcgtaac caccacaccc     7080

gccgcgctta atgcgccgct acagggcgcg tcccattcgc cattcaggct gcgcaactgt     7140

tgggaagggc gatcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt     7200

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg     7260

acggccagtg agcgcgcgta atacgactca ctatagggcg aattgggtac cgggcccccc     7320

ctcgatcgag                                                            7330


<210>  3
<211>  5720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid pENN.AAV.cTnT.PI.Sun1-dom-neg

<400>  3
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gaattcgccc ttacgggccc cccctcgagg tcgggataaa      240

agcagtctgg gctttcacat gacagcatct ggggctgcgg cagagggtcg ggtccgaagc      300

gctgccttat cagcgcccca gccctgggag gtgacagctg gctggcttgt gtcagcccct      360

cgggcactca cgtatctccg tccgacgggt ttaaaatagc aaaactctga ggccacacaa      420

tagcttgggc ttatatgggc tcctgtgggg gaagggggag cacggagggg gccggggccg      480

ctgctgccaa aatagcagct cacaagtgtt gcattcctct ctgggcgccg ggcacattcc      540

tgctggctct gcccgccccg gggtgggcgc cggggggacc ttaaagcctc tgccccccaa      600

ggagcccttc ccagacagcc gccggcaccc accgctccgt gggacgatcc ccgaagctct      660

agagctttat tgcggtagtt tatcacagtt aaattgctaa cgcagtcagt gcttctgaca      720

caacagtctc gaacttaagc tgcagaagtt ggtcgtgagg cactgggcag gtaagtatca      780

aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga cagagaagac      840

tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc tttctctcca      900

caggtgtcca ctcccagttc aattacagct cttaaggcta gagtacttaa tacgactcac      960

tataggctag cctcgagaat tcacgcgggc cgccatgaag tgggtaacct ttatttccct     1020

tctttttctc tttagctcgg cctattccag gggtgtgttt cgtcgagatg ggcccgctta     1080

cccttacgat gtaccggatt acgcactcga cgattccaag ggcatgcata gacctggccc     1140

tcttcccccg agcccacctc caaaggttga tcacaaggct tcccagtggc ctcaggagag     1200

tgacatgggg cagaaggtag cttctttgag tgcgcagtgc cacaaccatg atgagagact     1260

tgcagagctg acagtcctgc ttcagaaact acagatacgg gtagaccaag tggatgacgg     1320

cagggaaggg ctgtcactgt gggtcaagaa tgtggttgga cagcacctgc aggagatggg     1380

caccatagaa ccacctgatg ctaagactga cttcatgact ttccaccatg accatgaagt     1440

gcgtctctcc aacttggaag atgttcttag aaaactgaca gaaaaatctg aggctatcca     1500

gaaggagctg gaagaaacca agctgaaagc aggcagcagg gatgaagagc agcccctcct     1560

tgaccgtgtg cagcacctag aactggaact gaacctgttg aagtcacagc tgtcagactg     1620

gcagcatctg aagaccagct gtgagcaggc tggggcccgc atccaggaga ctgtgcagct     1680

catgttctct gaggatcagc agggcggttc cctcgagtgg ctattagaga agctttcttc     1740

tcggttcgtg agcaaggatg agctgcaggt gctcttacat gaccttgagc tgaaactgct     1800

gcagaatatc acacaccaca tcaccgtgac aggacaggcc ccgacatccg aggctattgt     1860

gtctgccgtg aatcaggcag ggatttcagg aatcacagaa gcgcaagcac atatcattgt     1920

gaacaatgct ctgaagctgt actcccaaga caagacgggg atggtggact ttgctctgga     1980

gtctggaggt ggcagcatcc taagcactcg gtgctctgag acctatgaga ccaagacggc     2040

actgctgagc ctgtttgggg tcccactgtg gtacttctca cagtcacctc gagtggtgat     2100

ccagcccgac atctacccag ggaattgctg ggcgttcaaa ggttcccagg ggtacctggt     2160

ggtgcggttg tccatgaaga tctacccaac cacattcacc atggaacaca ttccaaagac     2220

actatcaccc actggtaaca tctccagtgc ccccaaagac tttgcagtct atggactgga     2280

aacggagtat caagaagagg ggcagcctct gggacggttc acctatgacc aggaaggaga     2340

ctcactccag atgttccaca cactggaaag acctgaccaa gccttccaga tagtagagct     2400

ccgggtcctg tccaactggg gccaccctga gtacacttgc ctctaccggt tccgagtcca     2460

cggagagccc atccagaaag atgagttgta gtaaggtacc tctagagtcg acccgggcgg     2520

cctcgaggac ggggtgaact acgcctgagg atccgatctt tttccctctg ccaaaaatta     2580

tggggacatc atgaagcccc ttgagcatct gacttctggc taataaagga aatttatttt     2640

cattgcaata gtgtgttgga attttttgtg tctctcactc ggaagcaatt cgttgatctg     2700

aatttcgacc acccataata cccattaccc tggtagataa gtagcatggc gggttaatca     2760

ttaactacaa ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc     2820

tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag     2880

tgagcgagcg agcgcgcagc cttaattaac ctaattcact ggccgtcgtt ttacaacgtc     2940

gtgactggga aaaccctggc gttacccaac ttaatcgcct tgcagcacat ccccctttcg     3000

ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc     3060

tgaatggcga atgggacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta     3120

cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc     3180

cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt     3240

tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg     3300

gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca     3360

cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct atctcggtct     3420

attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa aatgagctga     3480

tttaacaaaa atttaacgcg aattttaaca aaatattaac gcttacaatt taggtggcac     3540

ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat     3600

gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag     3660

tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc     3720

tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc     3780

acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc     3840

cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc     3900

ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt     3960

ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt     4020

atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat     4080

cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct     4140

tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat     4200

gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc     4260

ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg     4320

ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc     4380

tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta     4440

cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc     4500

ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga     4560

tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat     4620

gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat     4680

caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa     4740

accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa     4800

ggtaactggc ttcagcagag cgcagatacc aaatactgtt cttctagtgt agccgtagtt     4860

aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt     4920

accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata     4980

gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt     5040

ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac     5100

gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga     5160

gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg     5220

ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa     5280

aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat     5340

gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc     5400

tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga     5460

agagcgccca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt aatgcagctg     5520

gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta atgtgagtta     5580

gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta tgttgtgtgg     5640

aattgtgagc ggataacaat ttcacacagg aaacagctat gaccatgatt acgccagatt     5700

taattaaggc cttaattagg                                                 5720


<210>  4
<211>  1461
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized Sun1DN


<220>
<221>  Start codon
<222>  (1)..(3)

<220>
<221>  Signal sequence
<222>  (4)..(84)

<220>
<221>  Sun1
<222>  (88)..(1446)

<220>
<221>  KDEL
<222>  (1447)..(1458)

<220>
<221>  Stop codon
<222>  (1459)..(1461)

<400>  4
atgaagtggg taacctttat ttcccttctt tttctcttta gctcggccta ttccaggggt       60

gtgtttcgtc gagatgggcc cgctctcgat gacccccagg acgtgtttaa acccacgact      120

tctcgcctga agcagcctct gcagggtgac agtgaggctt ttccgtggca ttggatgagt      180

ggcgtggagc agcaggtggc ctctctgtct ggacagtgcc accaccatgg tgagaatctc      240

cgagagctga ccactttgct acagaagctg caggctcggg tggaccagat ggaaggcggc      300

gctgccgggc cgtcagcttc ggtcagagac gctgtgggac agcccccgag ggagactgac      360

tttatggcct ttcaccaaga acatgaagtg cgtatgtcac acttggaaga tattctggga      420

aaactgagag aaaaatctga ggccatccag aaggaactag aacagaccaa gcaaaaaaca      480

atcagtgcgg ttggtgagca gctcctgccc acagtcgagc acctccagct ggagctggat      540

cagctaaagt cagagctgtc cagctggcga cacgtgaaga ccggctgtga gacagtggat      600

gccgtacaag aaagagtgga cgtgcaagtc agagaaatgg tgaaactcct gttttccgaa      660

gatcagcaag gcggttctct ggaacagctg ctgcagaggt tctcatcaca gtttgtgagc      720

aaaggcgact tgcagacgat gctgcgagac ctgcagctgc agatcctgcg gaacgtcacc      780

caccacgttt ccgtgaccaa gcagctccca acctcagaag ccgtggtgtc tgctgtgagc      840

gaggcggggg cgtctggaat aacagaggcg caagcacgtg ccatcgtgaa cagcgccttg      900

aagctgtatt cccaagataa gaccgggatg gtggactttg ctctggaatc tggtggtggc      960

agcatcttga gtactcgctg ttctgaaact tacgaaacca aaacggcgct gatgagtctg     1020

tttgggatcc cgctgtggta cttctcgcag tccccgcgcg tggtcatcca gcctgacatt     1080

taccccggta actgctgggc atttaaaggc tcccaggggt acctggtggt gaggctctcc     1140

atgatgatcc acccagccgc cttcactctg gagcacatcc ctaagacgct gtcgccaaca     1200

ggcaacatca gcagcgcccc caaggacttc gccgtctatg gattagaaaa tgagtatcag     1260

gaagaagggc agcttctggg acagttcacg tatgatcagg atggggagtc gctccagatg     1320

ttccaggccc tgaaaagacc cgacgacaca gctttccaaa tagtggaact tcggattttt     1380

tctaactggg gccatcctga gtatacctgt ctgtatcggt tcagagttca tggcgaacct     1440

gtcaagaaag atgagttgtg a                                               1461


<210>  5
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SUN2


<220>
<221>  Start codon
<222>  (1)..(3)

<220>
<221>  Signal sequence
<222>  (4)..(84)

<220>
<221>  Sun2
<222>  (88)..(1467)

<220>
<221>  KDEL
<222>  (1468)..(1479)

<220>
<221>  Stop codon
<222>  (1480)..(1482)

<400>  5
atgaagtggg taacctttat ttcccttctt tttctcttta gctcggccta ttccaggggt       60

gtgtttcgtc gagatgggcc cgctctcgat gagggctggg aagccagaga ctcatcgcca      120

catttccagg ctgagcagcg tgttatgtcc cgggtacact ctctggagcg gcgtctggaa      180

gctcttgctg ctgaattttc ctccaactgg cagaaggagg ccatgcggct ggaacgtctg      240

gagctgcggc aaggggctcc tggccaggga ggtggtggtg gcctgagcca cgaggacacc      300

ctggcgctgc tggaggggct agtgagccgc cgtgaagctg ccctgaagga ggatttccgc      360

agggaaactg ctgctcgcat ccaggaagaa ctgtctgccc tgagagcaga gcatcagcaa      420

gactcagaag acctcttcaa gaagatcgtc cgggcctccc aggagtccga ggctcgcatc      480

cagcagctga agtcagagtg gcaaagcatg acccaggagt ccttccagga gagctctgtg      540

aaggagctga ggcggctgga ggaccagctg gccggcctgc agcaggagct ggcggctctg      600

gcactgaagc agagctcggt ggcggaagaa gtgggcctgc tgccccagca gatccaggcc      660

gtgcgggacg acgtggaatc tcagttcccg gcctggatca gtcagttcct tgcccgaggt      720

ggagggggcc gcgtggggct ccttcagaga gaggagatgc aagctcagct gcgagagctg      780

gagagcaaga tcctcaccca tgtggcagag atgcagggca agtcggccag ggaagccgcg      840

gcctccctga gcctgacgct gcagaaagaa ggtgtgattg gagtgacaga ggagcaggtg      900

caccacatcg tgaagcaggc cctgcagcgc tacagtgagg accgcatcgg gctggcagac      960

tacgccctgg agtcaggagg ggccagcgtc atcagcaccc gatgttctga gacctacgag     1020

accaagacgg ccctcctcag cctcttcggc atccccctgt ggtaccactc ccagtcaccc     1080

cgagtcatcc tccagccaga tgtgcaccca ggcaactgct gggccttcca ggggccacaa     1140

ggcttcgccg tggtccgcct ctctgcccgc atccgcccca cagccgttac cttagagcat     1200

gtgcccaagg ccttgtcacc caacagcact atctccagtg cccccaagga cttcgccatc     1260

tttgggtttg acgaagacct gcagcaggag gggacactcc ttggcaagtt cacttacgat     1320

caggacggcg agcctattca gacgtttcac tttcaggccc ctacgatggc cacgtaccag     1380

gtggtggagc tgcggatcct gactaactgg ggccaccccg agtacacctg catctaccgc     1440

ttcagagtgc atggggagcc cgcccacaaa gatgagttgt ag                        1482


<210>  6
<211>  180
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KASH1, derived from Nesprin-1

<400>  6
cgcggcttcc tgttcagagt cctccgagca gctcttcccc ttcagcttct cctgctcctc       60

ctcatcgggc ttgcctgcct tgtaccaatg tcagaggaag actacagctg tgccctctcc      120

aacaactttg cccggtcatt ccaccccatg ctcagataca cgaatggccc tcctccactc      180


<210>  7
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KASH1 amino acid sequence

<400>  7

Arg Gly Phe Leu Phe Arg Val Leu Arg Ala Ala Leu Pro Leu Gln Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ile Gly Leu Ala Cys Leu Val Pro Met Ser Glu 
            20                  25                  30          


Glu Asp Tyr Ser Cys Ala Leu Ser Asn Asn Phe Ala Arg Ser Phe His 
        35                  40                  45              


Pro Met Leu Arg Tyr Thr Asn Gly Pro Pro Pro Leu 
    50                  55                  60  


<210>  8
<211>  180
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KASH2, derived from Nesprin-2

<400>  8
cgctccttcc tctcaagggt ggtccgggca gccctacccc tgcagctgct cctcctgctg       60

ctgctgctcc tggcctgcct gctgccctcc tccgaagaag actacagctg cactcaggcc      120

aacaactttg cccggtcctt ttaccccatg ctgaggtaca ccaatgggcc accccccaca      180


<210>  9
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KASH2 amino acid sequence

<400>  9

Arg Ser Phe Leu Ser Arg Val Val Arg Ala Ala Leu Pro Leu Gln Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Ala Cys Leu Leu Pro Ser Ser Glu 
            20                  25                  30          


Glu Asp Tyr Ser Cys Thr Gln Ala Asn Asn Phe Ala Arg Ser Phe Tyr 
        35                  40                  45              


Pro Met Leu Arg Tyr Thr Asn Gly Pro Pro Pro Thr 
    50                  55                  60  


<210>  10
<211>  177
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KASH3, derived from Nesprin-3

<400>  10
ggctccctct tccggagggc gtgctgtgtg gcgctcccac tgcagctgct tctgctgctg       60

ttcctcctcc tgctgttcct gctcccaatc agggaagagg accgcagctg caccctggcc      120

aacaacttcg cccgctcctt cacgctcatg ctgcgctaca atggcccacc acccacc         177


<210>  11
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KASH3 amino acid sequence

<400>  11

Gly Ser Leu Phe Arg Arg Ala Cys Cys Val Ala Leu Pro Leu Gln Leu 
1               5                   10                  15      


Leu Leu Leu Leu Phe Leu Leu Leu Leu Phe Leu Leu Pro Ile Arg Glu 
            20                  25                  30          


Glu Asp Arg Ser Cys Thr Leu Ala Asn Asn Phe Ala Arg Ser Phe Thr 
        35                  40                  45              


Leu Met Leu Arg Tyr Asn Gly Pro Pro Pro Thr 
    50                  55                  


<210>  12
<211>  174
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KASH4, derived from Nesprin-4

<400>  12
gatcctgcat ccaggcagcc tctgaccttc ctccttatcc tcttcctcct cttcctcctc       60

ctggtgggtg ccatgtttct cctgcccgcg tcaggaggcc cctgctgctc tcatgcccga      120

atacccagga caccctacct ggtgctcagc tatgtcaatg gtcttccccc agtc            174


<210>  13
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KASH4 amino acid sequence

<400>  13

Asp Pro Ala Ser Arg Gln Pro Leu Thr Phe Leu Leu Ile Leu Phe Leu 
1               5                   10                  15      


Leu Phe Leu Leu Leu Val Gly Ala Met Phe Leu Leu Pro Ala Ser Gly 
            20                  25                  30          


Gly Pro Cys Cys Ser His Ala Arg Ile Pro Arg Thr Pro Tyr Leu Val 
        35                  40                  45              


Leu Ser Tyr Val Asn Gly Leu Pro Pro Val 
    50                  55              


<210>  14
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KASH5, derived from CCDC155/KASH5

<400>  14
ctcagagtca ctcgacatcc actgatccca gctcctgtcc tgggcctgct gctgctgctg       60

ctgctctctg tcctgctgct tggcccgtcc ccacctccca cctggcccca cctccagctc      120

tgctacctcc agccccctcc agtg                                             144


<210>  15
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KASH5 amino acid sequence

<400>  15

Leu Arg Val Thr Arg His Pro Leu Ile Pro Ala Pro Val Leu Gly Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ser Val Leu Leu Leu Gly Pro Ser Pro Pro 
            20                  25                  30          


Pro Thr Trp Pro His Leu Gln Leu Cys Tyr Leu Gln Pro Pro Pro Val 
        35                  40                  45              


<210>  16
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FLX/FLX-F1 primer

<400>  16
ccagcttaca gagcaccgag ct                                                22


<210>  17
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FLX/FLX-F2 primer

<400>  17
tccttgcagt ccctcttgca tc                                                22


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FLX/FLX-R1 primer

<400>  18
aggcaccatt gtcacagggt c                                                 21


<210>  19
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sun1-F primer

<400>  19
ggcaagtgga tctcttgtga attcttgac                                         29


<210>  20
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sun1-R primer

<400>  20
gtagcaccca ccttggtgag ctggtac                                           27


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sun1-E8 primer

<400>  21
agccacataa ccacctggag                                                   20


<210>  22
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MyHC-tF primer

<400>  22
atgacagaca gatccctcct atctcc                                            26


<210>  23
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MyHC-tR primer

<400>  23
ctcatcactc gttgcatcat cgac                                              24


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MyHC-F primer

<400>  24
caaatgttgc ttgtctggtg                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MyHC-R primer

<400>  25
gtcagtcgag tgcacagttt                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mcm-3798t primer

<400>  26
aggtggacct gatcatggag                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mcm-8346t primer

<400>  27
ataccggaga tcatgcaagc                                                   20


<210>  28
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mcm-7338 primer

<400>  28
ctaggccaca gaattgaaag atct                                              24


<210>  29
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mcm-7339 primer

<400>  29
gtaggtggaa attctagcat catcc                                             25


<210>  30
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aav Sun1 F primer

<400>  30
cgagaattca cgcgggccgc catgaagtgg gtaaccttta tttc                        44


<210>  31
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aav Sun1 R primer

<400>  31
cgggtcgact ctagaggtac cttactacaa ctcatctttc tggatg                      46


<210>  32
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aav GFP Sun R primer

<400>  32
cgggtcgact ctagaggtac ttactacaac tcatctttgg atcc                        44


<210>  33
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sun1 delSUN RNA guide sequence

<400>  33
gcacaatagc ctcggatgtc g                                                 21


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syne1-stop guide RNA sequence

<400>  34
ccgttggtat atctgagcat                                                   20


<210>  35
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tyrosinase4a guide RNA sequence

<400>  35
ggttatggcc gataggtgca t                                                 21


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Common reverse primer for in vitro transcription

<400>  36
aaaagcaccg actcggtgcc                                                   20


<210>  37
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sun1delSUN gRNA-specific forward primer

<400>  37
ttaatacgac tcactatagc acaatagcct cggatgtcg                              39


<210>  38
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syne1-stop gRNA-specific forward primer

<400>  38
ttaatacgac tcactatagc cgttggtata tctgagcat                              39


<210>  39
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tyrosinase4a gRNA-specific forward primer

<400>  39
ttaatacgac tcactatagg ttatggccga taggtgcat                              39


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syne1CT' del8 forward primer

<400>  40
tgctcctgct gctgcttatt                                                   20


<210>  41
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syne1CT' del8 reverse primer

<400>  41
acatggtgga gcatttgtct cc                                                22


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sun1 CRISPR forward primer

<400>  42
tgaccttgag ctgaaactgc                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sun1 CRISPR reverse primer

<400>  43
tcagaacact ggcacacaca                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SYNE1

<400>  44
tcgtgtatct gagcatgggg                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SYNE1

<400>  45
gccattcgtg tatctgagca                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SYNE1

<400>  46
tccaccccat gctcagatac                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SYNE1

<400>  47
gagcatgggg tggaatgacc                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SYNE1

<400>  48
tgagcatggg gtggaatgac                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SYNE1

<400>  49
tcgtgtatct gagcatgggg                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SYNE1

<400>  50
cattcgtgta tctgagcatg                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SYNE1

<400>  51
ccattcgtgt atctgagcat                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SYNE1

<400>  52
gccattcgtg tatctgagca                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SYNE1

<400>  53
cccatgctca gatacacgaa                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SYNE1

<400>  54
cccggtcatt ccaccccatg                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SUN1

<400>  55
tttttctaac tggggccatc                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SUN1

<400>  56
ccgatacaga caggtatact                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SUN1

<400>  57
aacttcggat tttttctaac                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SUN1

<400>  58
acttcggatt ttttctaact                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SUN1

<400>  59
cttcggattt tttctaactg                                                   20


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SUN1

<400>  60
acagacaggt atactcagga                                                   20


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SUN1

<400>  61
ctgagtatac ctgtctgtat                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SUN1

<400>  62
ttctaactgg ggccatcctg                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SUN1

<400>  63
tctaactggg gccatcctga                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SUN1

<400>  64
ctaactgggg ccatcctgag                                                   20


<210>  65
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Potential guide RNA sequence, SUN1

<400>  65
taactggggc catcctgagt                                                   20


<210>  66
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 mRNA and gRNA targeting SUN1 domain

<400>  66
gcacaatagc ctcggatgtc g                                                 21


<210>  67
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cas9 mRNA and gRNA targeting the KASH1 domain

<400>  67
ccgttggtat atctgagcat                                                   20


<210>  68
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA targeting tyrosinase

<400>  68
ggttatggcc gataggtgca t                                                 21


<210>  69
<211>  176
<212>  DNA
<213>  Mus musculus

<400>  69
catgaccttg agctgaaact gctgcagaat atcacacacc acatcaccgt gacaggacag       60

gccccgacat ccgaggctat tgtgtctgcc gtgaatcagg cagggatttc aggaatcaca      120

gaagcgcaag cacatatcat tgtgaacaat gctctgaagc tgtactccca agacaa          176


<210>  70
<211>  180
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sun1_plus4

<400>  70
catgaccttg agctgaaact gctgcagaat atcacacacc acatcaccgt gacaggacag       60

gccccgagac acatccgagg ctattgtgtc tgccgtgaat caggcaggga tttcaggaat      120

cacagaagcg caagcacata tcattgtgaa caatgctctg aagctgtact cccaagacaa      180


<210>  71
<211>  169
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sun1_del7

<400>  71
catgaccttg agctgaaact gctgcagaat atcacacacc acatcaccgt gacaggacag       60

gccccgaggc tattgtgtct gccgtgaatc aggcagggat ttcaggaatc acagaagcgc      120

aagcacatat cattgtgaac aatgctctga agctgtactc ccaagacaa                  169


<210>  72
<211>  253
<212>  PRT
<213>  Mus musculus

<400>  72

Trp Leu Leu Glu Lys Leu Ser Ser Arg Phe Val Ser Lys Asp Glu Leu 
1               5                   10                  15      


Gln Val Leu Leu His Asp Leu Glu Leu Lys Leu Leu Gln Asn Ile Thr 
            20                  25                  30          


His His Ile Thr Val Thr Gly Gln Ala Pro Thr Ser Glu Ala Ile Val 
        35                  40                  45              


Ser Ala Val Asn Gln Ala Gly Ile Ser Gly Ile Thr Glu Ala Gln Ala 
    50                  55                  60                  


His Ile Ile Val Asn Asn Ala Leu Lys Leu Tyr Ser Gln Asp Lys Thr 
65                  70                  75                  80  


Gly Met Val Asp Phe Ala Leu Glu Ser Gly Gly Gly Ser Ile Leu Ser 
                85                  90                  95      


Thr Arg Cys Ser Glu Thr Tyr Glu Thr Lys Thr Ala Leu Leu Ser Leu 
            100                 105                 110         


Phe Gly Val Pro Leu Trp Tyr Phe Ser Gln Ser Pro Arg Val Val Ile 
        115                 120                 125             


Gln Pro Asp Ile Tyr Pro Gly Asn Cys Trp Ala Phe Lys Gly Ser Gln 
    130                 135                 140                 


Gly Tyr Leu Val Val Arg Leu Ser Met Lys Ile Tyr Pro Thr Thr Phe 
145                 150                 155                 160 


Thr Met Glu His Ile Pro Lys Thr Leu Ser Pro Thr Gly Asn Ile Ser 
                165                 170                 175     


Ser Ala Pro Lys Asp Phe Ala Val Tyr Gly Leu Glu Thr Glu Tyr Gln 
            180                 185                 190         


Glu Glu Gly Gln Pro Leu Gly Arg Phe Thr Tyr Asp Gln Glu Gly Asp 
        195                 200                 205             


Ser Leu Gln Met Phe His Thr Leu Glu Arg Pro Asp Gln Ala Phe Gln 
    210                 215                 220                 


Ile Val Glu Leu Arg Val Leu Ser Asn Trp Gly His Pro Glu Tyr Thr 
225                 230                 235                 240 


Cys Leu Tyr Arg Phe Arg Val His Gly Glu Pro Ile Gln 
                245                 250             


<210>  73
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sun1_plus4 protein

<400>  73

Trp Leu Leu Glu Lys Leu Ser Ser Arg Phe Val Ser Lys Asp Glu Leu 
1               5                   10                  15      


Gln Val Leu Leu His Asp Leu Glu Leu Lys Leu Leu Gln Asn Ile Thr 
            20                  25                  30          


His His Ile Thr Val Thr Gly Gln Ala Pro Arg His Ile Arg Gly Tyr 
        35                  40                  45              


Cys Val Cys Arg Glu Ser Gly Arg Asp Phe Arg Asn His Arg Ser Ala 
    50                  55                  60                  


Ser Thr Tyr His Cys Glu Gln Cys Ser Glu Ala Val Leu Pro Arg Gln 
65                  70                  75                  80  


Asp Gly Asp Gly Gly Leu Cys Ser Gly Val Trp Arg Trp Gln His Pro 
                85                  90                  95      


Lys His Ser Val Leu 
            100     


<210>  74
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sun1_del7 protein

<400>  74

Trp Leu Leu Glu Lys Leu Ser Ser Arg Phe Val Ser Lys Asp Glu Leu 
1               5                   10                  15      


Gln Val Leu Leu His Asp Leu Glu Leu Lys Leu Leu Gln Asn Ile Thr 
            20                  25                  30          


His His Ile Thr Val Thr Gly Gln Ala Pro Arg Leu Leu Cys Leu Pro 
        35                  40                  45              


<210>  75
<211>  180
<212>  DNA
<213>  Mus musculus

<400>  75
tattggactc acctgccttg tacccatgtc agagaaagac tacagctgtg ccctctccaa       60

caactttgcc cgatccttcc atccgatgct cagatatacc aacggtcctc ctccactctg      120

aagcaagcag acatccccac acaagtgcag gcagtaagag gagaaggaat atcaaatggc      180


<210>  76
<211>  172
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syne1_CTdel8

<400>  76
tattggactc acctgccttg tacccatgtc agagaaagac tacagctgtg ccctctccaa       60

caactttgcc cgatccttcc atccgatata ccaacggtcc tcctccactc tgaagcaagc      120

agacatcccc acacaagtgc aggcagtaag aggagaagga atatcaaatg gc              172


<210>  77
<211>  79
<212>  PRT
<213>  Mus musculus

<400>  77

Ser Thr Arg Asp Gly Ser Asp Ser Ser Arg Ser Asp Pro Arg Pro Glu 
1               5                   10                  15      


Arg Val Gly Arg Ala Phe Leu Phe Arg Ile Leu Arg Ala Ala Leu Pro 
            20                  25                  30          


Phe Gln Leu Leu Leu Leu Leu Leu Ile Gly Leu Thr Cys Leu Val Pro 
        35                  40                  45              


Met Ser Glu Lys Asp Tyr Ser Cys Ala Leu Ser Asn Asn Phe Ala Arg 
    50                  55                  60                  


Ser Phe His Pro Met Leu Arg Tyr Thr Asn Gly Pro Pro Pro Leu 
65                  70                  75                  


<210>  78
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nesprin1_CTdel8

<400>  78

Ser Thr Arg Asp Gly Ser Asp Ser Ser Arg Ser Asp Pro Arg Pro Glu 
1               5                   10                  15      


Arg Val Gly Arg Ala Phe Leu Phe Arg Ile Leu Arg Ala Ala Leu Pro 
            20                  25                  30          


Phe Gln Leu Leu Leu Leu Leu Leu Ile Gly Leu Thr Cys Leu Val Pro 
        35                  40                  45              


Met Ser Glu Lys Asp Tyr Ser Cys Ala Leu Ser Asn Asn Phe Ala Arg 
    50                  55                  60                  


Ser Phe His Pro Ile Tyr Gln Arg Ser Ser Ser Thr Leu Lys Gln Ala 
65                  70                  75                  80  


Asp Ile Pro Thr Gln Val Gln Ala Val Arg Gly Glu Gly Ile Ser Asn 
                85                  90                  95      


Gly Arg Glu Ala Pro Lys Glu Lys Phe Asn Ile Leu Asn His Gln Gly 
            100                 105                 110         


Asn Ala Asn Gln Asn Asn Pro Glu Met Glu Thr Asn Ala Pro Pro Cys 
        115                 120                 125             


Ser 
    


<210>  79
<211>  183
<212>  DNA
<213>  Homo sapiens

<400>  79
cgcggcttcc tgttcagagt cctccgagca gctcttcccc ttcagcttct cctgctcctc       60

ctcatcgggc ttgcctgcct tgtaccaatg tcagaggaag actacagctg tgccctctcc      120

aacaactttg cccggtcatt ccaccccatg ctcagataca cgaatggccc tcctccactc      180

tga                                                                    183


<210>  80
<211>  534
<212>  DNA
<213>  Homo sapiens

<400>  80
gataagaccg ggatggtgga ctttgctctg gaatctggtg gtggcagcat cttgagtact       60

cgctgttctg aaacttacga aaccaaaacg gcgctgatga gtctgtttgg gatcccgctg      120

tggtacttct cgcagtcccc gcgcgtggtc atccagcctg acatttaccc cggtaactgc      180

tgggcattta aaggctccca ggggtacctg gtggtgaggc tctccatgat gatccaccca      240

gccgccttca ctctggagca catccctaag acgctgtcgc caacaggcaa catcagcagc      300

gcccccaagg acttcgccgt ctatggatta gaaaatgagt atcaggaaga agggcagctt      360

ctgggacagt tcacgtatga tcaggatggg gagtcgctcc agatgttcca ggccctgaaa      420

agacccgacg acacagcttt ccaaatagtg gaacttcgga ttttttctaa ctggggccat      480

cctgagtata cctgtctgta tcggttcaga gttcatggcg aacctgtcaa gtga            534


<210>  81
<211>  117
<212>  DNA
<213>  Homo sapiens

<400>  81
aaaagacccg acgacacagc tttccaaata gtggaacttc ggattttttc taactggggc       60

catcctgagt atacctgtct gtatcggttc agagttcatg gcgaacctgt caagtga         117


<210>  82
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  82

Gly Gly Ser Ile Leu Ser Thr Arg Cys Ser Glu Thr Tyr Glu Thr Lys 
1               5                   10                  15      


Thr Ala Leu Met Ser Leu Phe Gly Ile Pro Leu Trp Tyr Phe Ser Gln 
            20                  25                  30          


Ser Pro Arg Val Val Ile Gln Pro Asp Ile Tyr Pro Gly Asn Cys Trp 
        35                  40                  45              


Ala Phe Lys Gly Ser Gln Gly Tyr Leu Val Val Arg Leu Ser Met Met 
    50                  55                  60                  


Ile His Pro Ala Ala Phe Thr Leu Glu His Ile Pro Lys Thr Leu Ser 
65                  70                  75                  80  


Pro Thr Gly Asn Ile Ser Ser Ala Pro Lys Asp Phe Ala Val Tyr Gly 
                85                  90                  95      


Leu Glu Asn Glu Tyr Gln Glu Glu Gly Gln Leu Leu Gly Gln Phe Thr 
            100                 105                 110         


Tyr Asp Gln Asp Gly Glu Ser Leu Gln Met Phe Gln Ala Leu Lys Arg 
        115                 120                 125             


Pro Asp Asp Thr Ala Phe Gln Ile Val Glu Leu Arg Ile Phe Ser Asn 
    130                 135                 140                 


Trp Gly His Pro Glu Tyr Thr Cys Leu Tyr Arg Phe Arg Val His Gly 
145                 150                 155                 160 


Glu Pro Val 
            


<210>  83
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  83

Gly Ala Ser Val Ile Ser Thr Arg Cys Ser Glu Thr Tyr Glu Thr Lys 
1               5                   10                  15      


Thr Ala Leu Leu Ser Leu Phe Gly Ile Pro Leu Trp Tyr His Ser Gln 
            20                  25                  30          


Ser Pro Arg Val Ile Leu Gln Pro Asp Val His Pro Gly Asn Cys Trp 
        35                  40                  45              


Ala Phe Gln Gly Pro Gln Gly Phe Ala Val Val Arg Leu Ser Ala Arg 
    50                  55                  60                  


Ile Arg Pro Thr Ala Val Thr Leu Glu His Val Pro Lys Ala Leu Ser 
65                  70                  75                  80  


Pro Asn Ser Thr Ile Ser Ser Ala Pro Lys Asp Phe Ala Ile Phe Gly 
                85                  90                  95      


Phe Asp Glu Asp Leu Gln Gln Glu Gly Thr Leu Leu Gly Lys Phe Thr 
            100                 105                 110         


Tyr Asp Gln Asp Gly Glu Pro Ile Gln Thr Phe His Phe Gln Ala Pro 
        115                 120                 125             


Thr Met Ala Thr Tyr Gln Val Val Glu Leu Arg Ile Leu Thr Asn Trp 
    130                 135                 140                 


Gly His Pro Glu Tyr Thr Cys Ile Tyr Arg Phe Arg Val His Gly Glu 
145                 150                 155                 160 


Pro Ala 
        


<210>  84
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  84

Gly Ala Ser Ile Ile Glu Ala Gly Thr Ser Glu Ser Tyr Lys Asn Asn 
1               5                   10                  15      


Lys Ala Lys Leu Tyr Trp His Gly Ile Gly Phe Leu Asn His Glu Met 
            20                  25                  30          


Pro Pro Asp Ile Ile Leu Gln Pro Asp Val Tyr Pro Gly Lys Cys Trp 
        35                  40                  45              


Ala Phe Pro Gly Ser Gln Gly His Thr Leu Ile Lys Leu Ala Thr Lys 
    50                  55                  60                  


Ile Ile Pro Thr Ala Val Thr Met Glu His Ile Ser Glu Lys Val Ser 
65                  70                  75                  80  


Pro Ser Gly Asn Ile Ser Ser Ala Pro Lys Glu Phe Ser Val Tyr Gly 
                85                  90                  95      


Ile Thr Lys Lys Cys Glu Gly Glu Glu Ile Phe Leu Gly Gln Phe Ile 
            100                 105                 110         


Tyr Asn Lys Thr Gly Thr Thr Val Gln Thr Phe Glu Leu Gln His Ala 
        115                 120                 125             


Val Ser Glu Tyr Leu Leu Cys Val Lys Leu Asn Ile Phe Ser Asn Trp 
    130                 135                 140                 


Gly His Pro Lys Tyr Thr Cys Leu Tyr Arg Phe Arg Val His Gly Thr 
145                 150                 155                 160 


Pro Gly 
        


<210>  85
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  85

Gly Ala Ser Ile Asp Phe Glu His Thr Ser Val Thr Tyr Asn His Glu 
1               5                   10                  15      


Lys Ala His Ser Tyr Trp Asn Trp Ile Gln Leu Trp Asn Tyr Ala Gln 
            20                  25                  30          


Pro Pro Asp Val Ile Leu Glu Pro Asn Val Thr Pro Gly Asn Cys Trp 
        35                  40                  45              


Ala Phe Glu Gly Asp Arg Gly Gln Val Thr Ile Gln Leu Ala Gln Lys 
    50                  55                  60                  


Val Tyr Leu Ser Asn Leu Thr Leu Gln His Ile Pro Lys Thr Ile Ser 
65                  70                  75                  80  


Leu Ser Gly Ser Leu Asp Thr Ala Pro Lys Asp Phe Val Ile Tyr Gly 
                85                  90                  95      


Met Glu Gly Ser Pro Lys Glu Glu Val Phe Leu Gly Ala Phe Gln Phe 
            100                 105                 110         


Gln Pro Glu Asn Ile Ile Gln Met Phe Pro Leu Gln Asn Gln Pro Ala 
        115                 120                 125             


Arg Ala Phe Ser Ala Val Lys Val Lys Ile Ser Ser Asn Trp Gly Asn 
    130                 135                 140                 


Pro Gly Phe Thr Cys Leu Tyr Arg Val Arg Val His Gly Ser Val Ala 
145                 150                 155                 160 


<210>  86
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  86

Gly Ala Ser Ile Asp Leu Gln Lys Thr Ser His Asp Tyr Ala Asp Arg 
1               5                   10                  15      


Asn Thr Ala Tyr Phe Trp Asn Arg Phe Ser Phe Trp Asn Tyr Ala Arg 
            20                  25                  30          


Pro Pro Thr Val Ile Leu Glu Pro His Val Phe Pro Gly Asn Cys Trp 
        35                  40                  45              


Ala Phe Glu Gly Asp Gln Gly Gln Val Val Ile Gln Leu Pro Gly Arg 
    50                  55                  60                  


Val Gln Leu Ser Asp Ile Thr Leu Gln His Pro Pro Pro Ser Val Glu 
65                  70                  75                  80  


His Thr Gly Gly Ala Asn Ser Ala Pro Arg Asp Phe Ala Val Phe Gly 
                85                  90                  95      


Leu Gln Val Tyr Asp Glu Thr Glu Val Ser Leu Gly Lys Phe Thr Phe 
            100                 105                 110         


Asp Val Glu Lys Ser Glu Ile Gln Thr Phe His Leu Gln Asn Asp Pro 
        115                 120                 125             


Pro Ala Ala Phe Pro Lys Val Lys Ile Gln Ile Leu Ser Asn Trp Gly 
    130                 135                 140                 


His Pro Arg Phe Thr Cys Leu Tyr Arg Val Arg Ala His Gly Val Arg 
145                 150                 155                 160 


Thr 
    


<210>  87
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  87

Glu Lys Ser Gln Ser Met His Ala Ser Ser Asn Gly Gly Ser His Ala 
1               5                   10                  15      


Thr Lys Lys Val Gln Lys Asn Arg Asn Asn Tyr Ala Ser Val Glu Cys 
            20                  25                  30          


Gly Ala Lys Ile Leu Ala Ala Asn Pro Glu Ala Lys Ser Thr Ser Ala 
        35                  40                  45              


Ile Leu Ile Glu Asn Met Asp Leu Tyr Met Leu Asn Pro Cys Ser Thr 
    50                  55                  60                  


Lys Ile Trp Phe Val Ile Glu Leu Cys Glu Pro Ile Gln Val Lys Gln 
65                  70                  75                  80  


Leu Asp Ile Ala Asn Tyr Glu Leu Phe Ser Ser Thr Pro Lys Asp Phe 
                85                  90                  95      


Leu Val Ser Ile Ser Asp Arg Tyr Pro Thr Asn Lys Trp Ile Lys Leu 
            100                 105                 110         


Gly Thr Phe His Gly Arg Asp Glu Arg Asn Val Gln Ser Phe Pro Leu 
        115                 120                 125             


Asp Glu Gln Met Tyr Ala Lys Tyr Val Lys Met Phe Ile Lys Tyr Ile 
    130                 135                 140                 


Lys Val Glu Leu Leu Ser His Phe Gly Ser Glu His Phe Cys Pro Leu 
145                 150                 155                 160 


Ser Leu Ile Arg Val Phe Gly Thr Ser Met 
                165                 170 


<210>  88
<211>  812
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Asp Phe Ser Arg Leu His Met Tyr Ser Pro Pro Gln Cys Val Pro 
1               5                   10                  15      


Glu Asn Thr Gly Tyr Thr Tyr Ala Leu Ser Ser Ser Tyr Ser Ser Asp 
            20                  25                  30          


Ala Leu Asp Phe Glu Thr Glu His Lys Leu Asp Pro Val Phe Asp Ser 
        35                  40                  45              


Pro Arg Met Ser Arg Arg Ser Leu Arg Leu Ala Thr Thr Ala Cys Thr 
    50                  55                  60                  


Leu Gly Asp Gly Glu Ala Val Gly Ala Asp Ser Gly Thr Ser Ser Ala 
65                  70                  75                  80  


Val Ser Leu Lys Asn Arg Ala Ala Arg Thr Thr Lys Gln Arg Arg Ser 
                85                  90                  95      


Thr Asn Lys Ser Ala Phe Ser Ile Asn His Val Ser Arg Gln Val Thr 
            100                 105                 110         


Ser Ser Gly Val Ser His Gly Gly Thr Val Ser Leu Gln Asp Ala Val 
        115                 120                 125             


Thr Arg Arg Pro Pro Val Leu Asp Glu Ser Trp Ile Arg Glu Gln Thr 
    130                 135                 140                 


Thr Val Asp His Phe Trp Gly Leu Asp Asp Asp Gly Asp Leu Lys Gly 
145                 150                 155                 160 


Gly Asn Lys Ala Ala Ile Gln Gly Asn Gly Asp Val Gly Ala Ala Ala 
                165                 170                 175     


Ala Thr Ala His Asn Gly Phe Ser Cys Ser Asn Cys Ser Met Leu Ser 
            180                 185                 190         


Glu Arg Lys Asp Val Leu Thr Ala His Pro Ala Ala Pro Gly Pro Val 
        195                 200                 205             


Ser Arg Val Tyr Ser Arg Asp Arg Asn Gln Lys Cys Asp Asp Cys Lys 
    210                 215                 220                 


Gly Lys Arg His Leu Asp Ala His Pro Gly Arg Ala Gly Thr Leu Trp 
225                 230                 235                 240 


His Ile Trp Ala Cys Ala Gly Tyr Phe Leu Leu Gln Ile Leu Arg Arg 
                245                 250                 255     


Ile Gly Ala Val Gly Gln Ala Val Ser Arg Thr Ala Trp Ser Ala Leu 
            260                 265                 270         


Trp Leu Ala Val Val Ala Pro Gly Lys Ala Ala Ser Gly Val Phe Trp 
        275                 280                 285             


Trp Leu Gly Ile Gly Trp Tyr Gln Phe Val Thr Leu Ile Ser Trp Leu 
    290                 295                 300                 


Asn Val Phe Leu Leu Thr Arg Cys Leu Arg Asn Ile Cys Lys Phe Leu 
305                 310                 315                 320 


Val Leu Leu Ile Pro Leu Phe Leu Leu Leu Ala Gly Leu Ser Leu Arg 
                325                 330                 335     


Gly Gln Gly Asn Phe Phe Ser Phe Leu Pro Val Leu Asn Trp Ala Ser 
            340                 345                 350         


Met His Arg Thr Gln Arg Val Asp Asp Pro Gln Asp Val Phe Lys Pro 
        355                 360                 365             


Thr Thr Ser Arg Leu Lys Gln Pro Leu Gln Gly Asp Ser Glu Ala Phe 
    370                 375                 380                 


Pro Trp His Trp Met Ser Gly Val Glu Gln Gln Val Ala Ser Leu Ser 
385                 390                 395                 400 


Gly Gln Cys His His His Gly Glu Asn Leu Arg Glu Leu Thr Thr Leu 
                405                 410                 415     


Leu Gln Lys Leu Gln Ala Arg Val Asp Gln Met Glu Gly Gly Ala Ala 
            420                 425                 430         


Gly Pro Ser Ala Ser Val Arg Asp Ala Val Gly Gln Pro Pro Arg Glu 
        435                 440                 445             


Thr Asp Phe Met Ala Phe His Gln Glu His Glu Val Arg Met Ser His 
    450                 455                 460                 


Leu Glu Asp Ile Leu Gly Lys Leu Arg Glu Lys Ser Glu Ala Ile Gln 
465                 470                 475                 480 


Lys Glu Leu Glu Gln Thr Lys Gln Lys Thr Ile Ser Ala Val Gly Glu 
                485                 490                 495     


Gln Leu Leu Pro Thr Val Glu His Leu Gln Leu Glu Leu Asp Gln Leu 
            500                 505                 510         


Lys Ser Glu Leu Ser Ser Trp Arg His Val Lys Thr Gly Cys Glu Thr 
        515                 520                 525             


Val Asp Ala Val Gln Glu Arg Val Asp Val Gln Val Arg Glu Met Val 
    530                 535                 540                 


Lys Leu Leu Phe Ser Glu Asp Gln Gln Gly Gly Ser Leu Glu Gln Leu 
545                 550                 555                 560 


Leu Gln Arg Phe Ser Ser Gln Phe Val Ser Lys Gly Asp Leu Gln Thr 
                565                 570                 575     


Met Leu Arg Asp Leu Gln Leu Gln Ile Leu Arg Asn Val Thr His His 
            580                 585                 590         


Val Ser Val Thr Lys Gln Leu Pro Thr Ser Glu Ala Val Val Ser Ala 
        595                 600                 605             


Val Ser Glu Ala Gly Ala Ser Gly Ile Thr Glu Ala Gln Ala Arg Ala 
    610                 615                 620                 


Ile Val Asn Ser Ala Leu Lys Leu Tyr Ser Gln Asp Lys Thr Gly Met 
625                 630                 635                 640 


Val Asp Phe Ala Leu Glu Ser Gly Gly Gly Ser Ile Leu Ser Thr Arg 
                645                 650                 655     


Cys Ser Glu Thr Tyr Glu Thr Lys Thr Ala Leu Met Ser Leu Phe Gly 
            660                 665                 670         


Ile Pro Leu Trp Tyr Phe Ser Gln Ser Pro Arg Val Val Ile Gln Pro 
        675                 680                 685             


Asp Ile Tyr Pro Gly Asn Cys Trp Ala Phe Lys Gly Ser Gln Gly Tyr 
    690                 695                 700                 


Leu Val Val Arg Leu Ser Met Met Ile His Pro Ala Ala Phe Thr Leu 
705                 710                 715                 720 


Glu His Ile Pro Lys Thr Leu Ser Pro Thr Gly Asn Ile Ser Ser Ala 
                725                 730                 735     


Pro Lys Asp Phe Ala Val Tyr Gly Leu Glu Asn Glu Tyr Gln Glu Glu 
            740                 745                 750         


Gly Gln Leu Leu Gly Gln Phe Thr Tyr Asp Gln Asp Gly Glu Ser Leu 
        755                 760                 765             


Gln Met Phe Gln Ala Leu Lys Arg Pro Asp Asp Thr Ala Phe Gln Ile 
    770                 775                 780                 


Val Glu Leu Arg Ile Phe Ser Asn Trp Gly His Pro Glu Tyr Thr Cys 
785                 790                 795                 800 


Leu Tyr Arg Phe Arg Val His Gly Glu Pro Val Lys 
                805                 810         


<210>  89
<211>  717
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Ser Arg Arg Ser Gln Arg Leu Thr Arg Tyr Ser Gln Gly Asp Asp 
1               5                   10                  15      


Asp Gly Ser Ser Ser Ser Gly Gly Ser Ser Val Ala Gly Ser Gln Ser 
            20                  25                  30          


Thr Leu Phe Lys Asp Ser Pro Leu Arg Thr Leu Lys Arg Lys Ser Ser 
        35                  40                  45              


Asn Met Lys Arg Leu Ser Pro Ala Pro Gln Leu Gly Pro Ser Ser Asp 
    50                  55                  60                  


Ala His Thr Ser Tyr Tyr Ser Glu Ser Leu Val His Glu Ser Trp Phe 
65                  70                  75                  80  


Pro Pro Arg Ser Ser Leu Glu Glu Leu His Gly Asp Ala Asn Trp Gly 
                85                  90                  95      


Glu Asp Leu Arg Val Arg Arg Arg Arg Gly Thr Gly Gly Ser Glu Ser 
            100                 105                 110         


Ser Arg Ala Ser Gly Leu Val Gly Arg Lys Ala Thr Glu Asp Phe Leu 
        115                 120                 125             


Gly Ser Ser Ser Gly Tyr Ser Ser Glu Asp Asp Tyr Val Gly Tyr Ser 
    130                 135                 140                 


Asp Val Asp Gln Gln Ser Ser Ser Ser Arg Leu Arg Ser Ala Val Ser 
145                 150                 155                 160 


Arg Ala Gly Ser Leu Leu Trp Met Val Ala Thr Ser Pro Gly Arg Leu 
                165                 170                 175     


Phe Arg Leu Leu Tyr Trp Trp Ala Gly Thr Thr Trp Tyr Arg Leu Thr 
            180                 185                 190         


Thr Ala Ala Ser Leu Leu Asp Val Phe Val Leu Thr Arg Arg Phe Ser 
        195                 200                 205             


Ser Leu Lys Thr Phe Leu Trp Phe Leu Leu Pro Leu Leu Leu Leu Thr 
    210                 215                 220                 


Cys Leu Thr Tyr Gly Ala Trp Tyr Phe Tyr Pro Tyr Gly Leu Gln Thr 
225                 230                 235                 240 


Phe His Pro Ala Leu Val Ser Trp Trp Ala Ala Lys Asp Ser Arg Arg 
                245                 250                 255     


Pro Asp Glu Gly Trp Glu Ala Arg Asp Ser Ser Pro His Phe Gln Ala 
            260                 265                 270         


Glu Gln Arg Val Met Ser Arg Val His Ser Leu Glu Arg Arg Leu Glu 
        275                 280                 285             


Ala Leu Ala Ala Glu Phe Ser Ser Asn Trp Gln Lys Glu Ala Met Arg 
    290                 295                 300                 


Leu Glu Arg Leu Glu Leu Arg Gln Gly Ala Pro Gly Gln Gly Gly Gly 
305                 310                 315                 320 


Gly Gly Leu Ser His Glu Asp Thr Leu Ala Leu Leu Glu Gly Leu Val 
                325                 330                 335     


Ser Arg Arg Glu Ala Ala Leu Lys Glu Asp Phe Arg Arg Glu Thr Ala 
            340                 345                 350         


Ala Arg Ile Gln Glu Glu Leu Ser Ala Leu Arg Ala Glu His Gln Gln 
        355                 360                 365             


Asp Ser Glu Asp Leu Phe Lys Lys Ile Val Arg Ala Ser Gln Glu Ser 
    370                 375                 380                 


Glu Ala Arg Ile Gln Gln Leu Lys Ser Glu Trp Gln Ser Met Thr Gln 
385                 390                 395                 400 


Glu Ser Phe Gln Glu Ser Ser Val Lys Glu Leu Arg Arg Leu Glu Asp 
                405                 410                 415     


Gln Leu Ala Gly Leu Gln Gln Glu Leu Ala Ala Leu Ala Leu Lys Gln 
            420                 425                 430         


Ser Ser Val Ala Glu Glu Val Gly Leu Leu Pro Gln Gln Ile Gln Ala 
        435                 440                 445             


Val Arg Asp Asp Val Glu Ser Gln Phe Pro Ala Trp Ile Ser Gln Phe 
    450                 455                 460                 


Leu Ala Arg Gly Gly Gly Gly Arg Val Gly Leu Leu Gln Arg Glu Glu 
465                 470                 475                 480 


Met Gln Ala Gln Leu Arg Glu Leu Glu Ser Lys Ile Leu Thr His Val 
                485                 490                 495     


Ala Glu Met Gln Gly Lys Ser Ala Arg Glu Ala Ala Ala Ser Leu Ser 
            500                 505                 510         


Leu Thr Leu Gln Lys Glu Gly Val Ile Gly Val Thr Glu Glu Gln Val 
        515                 520                 525             


His His Ile Val Lys Gln Ala Leu Gln Arg Tyr Ser Glu Asp Arg Ile 
    530                 535                 540                 


Gly Leu Ala Asp Tyr Ala Leu Glu Ser Gly Gly Ala Ser Val Ile Ser 
545                 550                 555                 560 


Thr Arg Cys Ser Glu Thr Tyr Glu Thr Lys Thr Ala Leu Leu Ser Leu 
                565                 570                 575     


Phe Gly Ile Pro Leu Trp Tyr His Ser Gln Ser Pro Arg Val Ile Leu 
            580                 585                 590         


Gln Pro Asp Val His Pro Gly Asn Cys Trp Ala Phe Gln Gly Pro Gln 
        595                 600                 605             


Gly Phe Ala Val Val Arg Leu Ser Ala Arg Ile Arg Pro Thr Ala Val 
    610                 615                 620                 


Thr Leu Glu His Val Pro Lys Ala Leu Ser Pro Asn Ser Thr Ile Ser 
625                 630                 635                 640 


Ser Ala Pro Lys Asp Phe Ala Ile Phe Gly Phe Asp Glu Asp Leu Gln 
                645                 650                 655     


Gln Glu Gly Thr Leu Leu Gly Lys Phe Thr Tyr Asp Gln Asp Gly Glu 
            660                 665                 670         


Pro Ile Gln Thr Phe His Phe Gln Ala Pro Thr Met Ala Thr Tyr Gln 
        675                 680                 685             


Val Val Glu Leu Arg Ile Leu Thr Asn Trp Gly His Pro Glu Tyr Thr 
    690                 695                 700                 


Cys Ile Tyr Arg Phe Arg Val His Gly Glu Pro Ala His 
705                 710                 715         


<210>  90
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Ser Gly Lys Thr Lys Ala Arg Arg Ala Ala Met Phe Phe Arg Arg 
1               5                   10                  15      


Cys Ser Glu Asp Ala Ser Gly Ser Ala Ser Gly Asn Ala Leu Leu Ser 
            20                  25                  30          


Glu Asp Glu Asn Pro Asp Ala Asn Gly Val Thr Arg Ser Trp Lys Ile 
        35                  40                  45              


Ile Leu Ser Thr Met Leu Thr Leu Thr Phe Leu Leu Val Gly Leu Leu 
    50                  55                  60                  


Asn His Gln Trp Leu Lys Glu Thr Asp Val Pro Gln Lys Ser Arg Gln 
65                  70                  75                  80  


Leu Tyr Ala Ile Ile Ala Glu Tyr Gly Ser Arg Leu Tyr Lys Tyr Gln 
                85                  90                  95      


Ala Arg Leu Arg Met Pro Lys Glu Gln Leu Glu Leu Leu Lys Lys Glu 
            100                 105                 110         


Ser Gln Asn Leu Glu Asn Asn Phe Arg Gln Ile Leu Phe Leu Ile Glu 
        115                 120                 125             


Gln Ile Asp Val Leu Lys Ala Leu Leu Arg Asp Met Lys Asp Gly Met 
    130                 135                 140                 


Asp Asn Asn His Asn Trp Asn Thr His Gly Asp Pro Val Glu Asp Pro 
145                 150                 155                 160 


Asp His Thr Glu Glu Val Ser Asn Leu Val Asn Tyr Val Leu Lys Lys 
                165                 170                 175     


Leu Arg Glu Asp Gln Val Glu Met Ala Asp Tyr Ala Leu Lys Ser Ala 
            180                 185                 190         


Gly Ala Ser Ile Ile Glu Ala Gly Thr Ser Glu Ser Tyr Lys Asn Asn 
        195                 200                 205             


Lys Ala Lys Leu Tyr Trp His Gly Ile Gly Phe Leu Asn His Glu Met 
    210                 215                 220                 


Pro Pro Asp Ile Ile Leu Gln Pro Asp Val Tyr Pro Gly Lys Cys Trp 
225                 230                 235                 240 


Ala Phe Pro Gly Ser Gln Gly His Thr Leu Ile Lys Leu Ala Thr Lys 
                245                 250                 255     


Ile Ile Pro Thr Ala Val Thr Met Glu His Ile Ser Glu Lys Val Ser 
            260                 265                 270         


Pro Ser Gly Asn Ile Ser Ser Ala Pro Lys Glu Phe Ser Val Tyr Gly 
        275                 280                 285             


Ile Thr Lys Lys Cys Glu Gly Glu Glu Ile Phe Leu Gly Gln Phe Ile 
    290                 295                 300                 


Tyr Asn Lys Thr Gly Thr Thr Val Gln Thr Phe Glu Leu Gln His Ala 
305                 310                 315                 320 


Val Ser Glu Tyr Leu Leu Cys Val Lys Leu Asn Ile Phe Ser Asn Trp 
                325                 330                 335     


Gly His Pro Lys Tyr Thr Cys Leu Tyr Arg Phe Arg Val His Gly Thr 
            340                 345                 350         


Pro Gly Lys His Ile 
        355         


<210>  91
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Pro Arg Ser Ser Arg Ser Pro Gly Asp Pro Gly Ala Leu Leu Glu 
1               5                   10                  15      


Asp Val Ala His Asn Pro Arg Pro Arg Arg Ile Ala Gln Arg Gly Arg 
            20                  25                  30          


Asn Thr Ser Arg Met Ala Glu Asp Thr Ser Pro Asn Met Thr Trp Phe 
        35                  40                  45              


Thr Cys Phe Ala Cys Ser Leu Arg Thr Gln Ala Gln Gln Val Leu Phe 
    50                  55                  60                  


Asn Thr Cys Arg Cys Lys Leu Leu Cys Gln Lys Leu Met Glu Lys Thr 
65                  70                  75                  80  


Gly Ile Leu Leu Leu Cys Ala Phe Gly Phe Trp Met Phe Ser Ile His 
                85                  90                  95      


Leu Pro Ser Lys Met Lys Val Trp Gln Asp Asp Ser Ile Asn Gly Pro 
            100                 105                 110         


Leu Gln Ser Leu Arg Leu Tyr Gln Glu Lys Val Arg His His Ser Gly 
        115                 120                 125             


Glu Ile Gln Asp Leu Arg Gly Ser Met Asn Gln Leu Ile Ala Lys Leu 
    130                 135                 140                 


Gln Glu Met Glu Ala Met Ser Asp Glu Gln Lys Met Ala Gln Lys Ile 
145                 150                 155                 160 


Met Lys Met Ile His Gly Asp Tyr Ile Glu Lys Pro Asp Phe Ala Leu 
                165                 170                 175     


Lys Ser Ile Gly Ala Ser Ile Asp Phe Glu His Thr Ser Val Thr Tyr 
            180                 185                 190         


Asn His Glu Lys Ala His Ser Tyr Trp Asn Trp Ile Gln Leu Trp Asn 
        195                 200                 205             


Tyr Ala Gln Pro Pro Asp Val Ile Leu Glu Pro Asn Val Thr Pro Gly 
    210                 215                 220                 


Asn Cys Trp Ala Phe Glu Gly Asp Arg Gly Gln Val Thr Ile Gln Leu 
225                 230                 235                 240 


Ala Gln Lys Val Tyr Leu Ser Asn Leu Thr Leu Gln His Ile Pro Lys 
                245                 250                 255     


Thr Ile Ser Leu Ser Gly Ser Leu Asp Thr Ala Pro Lys Asp Phe Val 
            260                 265                 270         


Ile Tyr Gly Met Glu Gly Ser Pro Lys Glu Glu Val Phe Leu Gly Ala 
        275                 280                 285             


Phe Gln Phe Gln Pro Glu Asn Ile Ile Gln Met Phe Pro Leu Gln Asn 
    290                 295                 300                 


Gln Pro Ala Arg Ala Phe Ser Ala Val Lys Val Lys Ile Ser Ser Asn 
305                 310                 315                 320 


Trp Gly Asn Pro Gly Phe Thr Cys Leu Tyr Arg Val Arg Val His Gly 
                325                 330                 335     


Ser Val Ala Pro Pro Arg Glu Gln Pro His Gln Asn Pro Tyr Pro Lys 
            340                 345                 350         


Arg Asp 
        


<210>  92
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Arg Arg Ser Ser Arg Pro Gly Ser Ala Ser Ser Ser Arg Lys His 
1               5                   10                  15      


Thr Pro Asn Phe Phe Ser Glu Asn Ser Ser Met Ser Ile Thr Ser Glu 
            20                  25                  30          


Asp Ser Lys Gly Leu Arg Ser Ala Glu Pro Gly Pro Gly Glu Pro Glu 
        35                  40                  45              


Gly Arg Arg Ala Arg Gly Pro Ser Cys Gly Glu Pro Ala Leu Ser Ala 
    50                  55                  60                  


Gly Val Pro Gly Gly Thr Thr Trp Ala Gly Ser Ser Gln Gln Lys Pro 
65                  70                  75                  80  


Ala Pro Arg Ser His Asn Trp Gln Thr Ala Cys Gly Ala Ala Thr Val 
                85                  90                  95      


Arg Gly Gly Ala Ser Glu Pro Thr Gly Ser Pro Val Val Ser Glu Glu 
            100                 105                 110         


Pro Leu Asp Leu Leu Pro Thr Leu Asp Leu Arg Gln Glu Met Pro Pro 
        115                 120                 125             


Pro Arg Val Phe Lys Ser Phe Leu Ser Leu Leu Phe Gln Gly Leu Ser 
    130                 135                 140                 


Val Leu Leu Ser Leu Ala Gly Asp Val Leu Val Ser Met Tyr Arg Glu 
145                 150                 155                 160 


Val Cys Ser Ile Arg Phe Leu Phe Thr Ala Val Ser Leu Leu Ser Leu 
                165                 170                 175     


Phe Leu Ser Ala Phe Trp Leu Gly Leu Leu Tyr Leu Val Ser Pro Leu 
            180                 185                 190         


Glu Asn Glu Pro Lys Glu Met Leu Thr Leu Ser Glu Tyr His Glu Arg 
        195                 200                 205             


Val Arg Ser Gln Gly Gln Gln Leu Gln Gln Leu Gln Ala Glu Leu Asp 
    210                 215                 220                 


Lys Leu His Lys Glu Val Ser Thr Val Arg Ala Ala Asn Ser Glu Arg 
225                 230                 235                 240 


Val Ala Lys Leu Val Phe Gln Arg Leu Asn Glu Asp Phe Val Arg Lys 
                245                 250                 255     


Pro Asp Tyr Ala Leu Ser Ser Val Gly Ala Ser Ile Asp Leu Gln Lys 
            260                 265                 270         


Thr Ser His Asp Tyr Ala Asp Arg Asn Thr Ala Tyr Phe Trp Asn Arg 
        275                 280                 285             


Phe Ser Phe Trp Asn Tyr Ala Arg Pro Pro Thr Val Ile Leu Glu Pro 
    290                 295                 300                 


His Val Phe Pro Gly Asn Cys Trp Ala Phe Glu Gly Asp Gln Gly Gln 
305                 310                 315                 320 


Val Val Ile Gln Leu Pro Gly Arg Val Gln Leu Ser Asp Ile Thr Leu 
                325                 330                 335     


Gln His Pro Pro Pro Ser Val Glu His Thr Gly Gly Ala Asn Ser Ala 
            340                 345                 350         


Pro Arg Asp Phe Ala Val Phe Gly Leu Gln Val Tyr Asp Glu Thr Glu 
        355                 360                 365             


Val Ser Leu Gly Lys Phe Thr Phe Asp Val Glu Lys Ser Glu Ile Gln 
    370                 375                 380                 


Thr Phe His Leu Gln Asn Asp Pro Pro Ala Ala Phe Pro Lys Val Lys 
385                 390                 395                 400 


Ile Gln Ile Leu Ser Asn Trp Gly His Pro Arg Phe Thr Cys Leu Tyr 
                405                 410                 415     


Arg Val Arg Ala His Gly Val Arg Thr Ser Glu Gly Ala Glu Gly Ser 
            420                 425                 430         


Ala Gln Gly Pro His 
        435         


<210>  93
<211>  1254
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Lys Lys His Arg Arg Ala Leu Ala Leu Val Ser Cys Leu Phe Leu 
1               5                   10                  15      


Cys Ser Leu Val Trp Leu Pro Ser Trp Arg Val Cys Cys Lys Glu Ser 
            20                  25                  30          


Ser Ser Ala Ser Ala Ser Ser Tyr Tyr Ser Gln Asp Asp Asn Cys Ala 
        35                  40                  45              


Leu Glu Asn Glu Asp Val Gln Phe Gln Lys Lys Asp Glu Arg Glu Gly 
    50                  55                  60                  


Pro Ile Asn Ala Glu Ser Leu Gly Lys Ser Gly Ser Asn Leu Pro Ile 
65                  70                  75                  80  


Ser Pro Lys Glu His Lys Leu Lys Asp Asp Ser Ile Val Asp Val Gln 
                85                  90                  95      


Asn Thr Glu Ser Lys Lys Leu Ser Pro Pro Val Val Glu Thr Leu Pro 
            100                 105                 110         


Thr Val Asp Leu His Glu Glu Ser Ser Asn Ala Val Val Asp Ser Glu 
        115                 120                 125             


Thr Val Glu Asn Ile Ser Ser Ser Ser Thr Ser Glu Ile Thr Pro Ile 
    130                 135                 140                 


Ser Lys Leu Asp Glu Ile Glu Lys Ser Gly Thr Ile Pro Ile Ala Lys 
145                 150                 155                 160 


Pro Ser Glu Thr Glu Gln Ser Glu Thr Asp Cys Asp Val Gly Glu Ala 
                165                 170                 175     


Leu Asp Ala Ser Ala Pro Ile Glu Gln Pro Ser Phe Val Ser Pro Pro 
            180                 185                 190         


Asp Ser Leu Val Gly Gln His Ile Glu Asn Val Ser Ser Ser His Gly 
        195                 200                 205             


Lys Gly Lys Ile Thr Lys Ser Glu Phe Glu Ser Lys Val Ser Ala Ser 
    210                 215                 220                 


Glu Gln Gly Gly Gly Asp Pro Lys Ser Ala Leu Asn Ala Ser Asp Asn 
225                 230                 235                 240 


Leu Lys Asn Glu Ser Ser Asp Tyr Thr Lys Pro Gly Asp Ile Asp Pro 
                245                 250                 255     


Thr Ser Val Ala Ser Pro Lys Asp Pro Glu Asp Ile Pro Thr Phe Asp 
            260                 265                 270         


Glu Trp Lys Lys Lys Val Met Glu Val Glu Lys Glu Lys Ser Gln Ser 
        275                 280                 285             


Met His Ala Ser Ser Asn Gly Gly Ser His Ala Thr Lys Lys Val Gln 
    290                 295                 300                 


Lys Asn Arg Asn Asn Tyr Ala Ser Val Glu Cys Gly Ala Lys Ile Leu 
305                 310                 315                 320 


Ala Ala Asn Pro Glu Ala Lys Ser Thr Ser Ala Ile Leu Ile Glu Asn 
                325                 330                 335     


Met Asp Leu Tyr Met Leu Asn Pro Cys Ser Thr Lys Ile Trp Phe Val 
            340                 345                 350         


Ile Glu Leu Cys Glu Pro Ile Gln Val Lys Gln Leu Asp Ile Ala Asn 
        355                 360                 365             


Tyr Glu Leu Phe Ser Ser Thr Pro Lys Asp Phe Leu Val Ser Ile Ser 
    370                 375                 380                 


Asp Arg Tyr Pro Thr Asn Lys Trp Ile Lys Leu Gly Thr Phe His Gly 
385                 390                 395                 400 


Arg Asp Glu Arg Asn Val Gln Ser Phe Pro Leu Asp Glu Gln Met Tyr 
                405                 410                 415     


Ala Lys Tyr Val Lys Met Phe Ile Lys Tyr Ile Lys Val Glu Leu Leu 
            420                 425                 430         


Ser His Phe Gly Ser Glu His Phe Cys Pro Leu Ser Leu Ile Arg Val 
        435                 440                 445             


Phe Gly Thr Ser Met Val Glu Glu Tyr Glu Glu Ile Ala Asp Ser Gln 
    450                 455                 460                 


Tyr His Ser Glu Arg Gln Glu Leu Phe Asp Glu Asp Tyr Asp Tyr Pro 
465                 470                 475                 480 


Leu Asp Tyr Asn Thr Gly Glu Asp Lys Ser Ser Lys Asn Leu Leu Gly 
                485                 490                 495     


Ser Ala Thr Asn Ala Ile Leu Asn Met Val Asn Ile Ala Ala Asn Ile 
            500                 505                 510         


Leu Gly Ala Lys Thr Glu Asp Leu Thr Glu Gly Asn Lys Ser Ile Ser 
        515                 520                 525             


Glu Asn Ala Thr Ala Thr Ala Ala Pro Lys Met Pro Glu Ser Thr Pro 
    530                 535                 540                 


Val Ser Thr Pro Val Pro Ser Pro Glu Tyr Val Thr Thr Glu Val His 
545                 550                 555                 560 


Thr His Asp Met Glu Pro Ser Thr Pro Asp Thr Pro Lys Glu Ser Pro 
                565                 570                 575     


Ile Val Gln Leu Val Gln Glu Glu Glu Glu Glu Ala Ser Pro Ser Thr 
            580                 585                 590         


Val Thr Leu Leu Gly Ser Gly Glu Gln Glu Asp Glu Ser Ser Pro Trp 
        595                 600                 605             


Phe Glu Ser Glu Thr Gln Ile Phe Cys Ser Glu Leu Thr Thr Ile Cys 
    610                 615                 620                 


Cys Ile Ser Ser Phe Ser Glu Tyr Ile Tyr Lys Trp Cys Ser Val Arg 
625                 630                 635                 640 


Val Ala Leu Tyr Arg Gln Arg Ser Arg Thr Ala Leu Ser Lys Gly Lys 
                645                 650                 655     


Asp Tyr Leu Val Leu Ala Gln Pro Pro Leu Leu Leu Pro Ala Glu Ser 
            660                 665                 670         


Val Asp Val Ser Val Leu Gln Pro Leu Ser Gly Glu Leu Glu Asn Thr 
        675                 680                 685             


Asn Ile Glu Arg Glu Ala Glu Thr Val Val Leu Gly Asp Leu Ser Ser 
    690                 695                 700                 


Ser Met His Gln Asp Asp Leu Val Asn His Thr Val Asp Ala Val Glu 
705                 710                 715                 720 


Leu Glu Pro Ser His Ser Gln Thr Leu Ser Gln Ser Leu Leu Leu Asp 
                725                 730                 735     


Ile Thr Pro Glu Ile Asn Pro Leu Pro Lys Ile Glu Val Ser Glu Ser 
            740                 745                 750         


Val Glu Tyr Glu Ala Gly His Ile Pro Ser Pro Val Ile Pro Gln Glu 
        755                 760                 765             


Ser Ser Val Glu Ile Asp Asn Glu Thr Glu Gln Lys Ser Glu Ser Phe 
    770                 775                 780                 


Ser Ser Ile Glu Lys Pro Ser Ile Thr Tyr Glu Thr Asn Lys Val Asn 
785                 790                 795                 800 


Glu Leu Met Asp Asn Ile Ile Lys Glu Asp Val Asn Ser Met Gln Ile 
                805                 810                 815     


Phe Thr Lys Leu Ser Glu Thr Ile Val Pro Pro Ile Asn Thr Ala Thr 
            820                 825                 830         


Val Pro Asp Asn Glu Asp Gly Glu Ala Lys Met Asn Ile Ala Asp Thr 
        835                 840                 845             


Ala Lys Gln Thr Leu Ile Ser Val Val Asp Ser Ser Ser Leu Pro Glu 
    850                 855                 860                 


Val Lys Glu Glu Glu Gln Ser Pro Glu Asp Ala Leu Leu Arg Gly Leu 
865                 870                 875                 880 


Gln Arg Thr Ala Thr Asp Phe Tyr Ala Glu Leu Gln Asn Ser Thr Asp 
                885                 890                 895     


Leu Gly Tyr Ala Asn Gly Asn Leu Val His Gly Ser Asn Gln Lys Glu 
            900                 905                 910         


Ser Val Phe Met Arg Leu Asn Asn Arg Ile Lys Ala Leu Glu Val Asn 
        915                 920                 925             


Met Ser Leu Ser Gly Arg Tyr Leu Glu Glu Leu Ser Gln Arg Tyr Arg 
    930                 935                 940                 


Lys Gln Met Glu Glu Met Gln Lys Ala Phe Asn Lys Thr Ile Val Lys 
945                 950                 955                 960 


Leu Gln Asn Thr Ser Arg Ile Ala Glu Glu Gln Asp Gln Arg Gln Thr 
                965                 970                 975     


Glu Ala Ile Gln Leu Leu Gln Ala Gln Leu Thr Asn Met Thr Gln Leu 
            980                 985                 990         


Val Ser Asn Leu Ser Ala Thr Val  Ala Glu Leu Lys Arg  Glu Val Ser 
        995                 1000                 1005             


Asp Arg  Gln Ser Tyr Leu Val  Ile Ser Leu Val Leu  Cys Val Val 
    1010                 1015                 1020             


Leu Gly  Leu Met Leu Cys Met  Gln Arg Cys Arg Asn  Thr Ser Gln 
    1025                 1030                 1035             


Phe Asp  Gly Asp Tyr Ile Ser  Lys Leu Pro Lys Ser  Asn Gln Tyr 
    1040                 1045                 1050             


Pro Ser  Pro Lys Arg Cys Phe  Ser Ser Tyr Asp Asp  Met Asn Leu 
    1055                 1060                 1065             


Lys Arg  Arg Thr Ser Phe Pro  Leu Met Arg Ser Lys  Ser Leu Gln 
    1070                 1075                 1080             


Leu Thr  Gly Lys Glu Val Asp  Pro Asn Asp Leu Tyr  Ile Val Glu 
    1085                 1090                 1095             


Pro Leu  Lys Phe Ser Pro Glu  Lys Lys Lys Lys Arg  Cys Lys Tyr 
    1100                 1105                 1110             


Lys Ile  Glu Lys Ile Glu Thr  Ile Lys Pro Glu Glu  Pro Leu His 
    1115                 1120                 1125             


Pro Ile  Ala Asn Gly Asp Ile  Lys Gly Arg Lys Pro  Phe Thr Asn 
    1130                 1135                 1140             


Gln Arg  Asp Phe Ser Asn Met  Gly Glu Val Tyr His  Ser Ser Tyr 
    1145                 1150                 1155             


Lys Gly  Pro Pro Ser Glu Gly  Ser Ser Glu Thr Ser  Ser Gln Ser 
    1160                 1165                 1170             


Glu Glu  Ser Tyr Phe Cys Gly  Ile Ser Ala Cys Thr  Ser Leu Cys 
    1175                 1180                 1185             


Asn Gly  Gln Ser Gln Lys Thr  Lys Thr Glu Lys Arg  Ala Leu Lys 
    1190                 1195                 1200             


Arg Arg  Arg Ser Lys Val Gln  Asp Gln Gly Lys Leu  Ile Lys Thr 
    1205                 1210                 1215             


Leu Ile  Gln Thr Lys Ser Gly  Ser Leu Pro Ser Leu  His Asp Ile 
    1220                 1225                 1230             


Ile Lys  Gly Asn Lys Glu Ile  Thr Val Gly Thr Phe  Gly Val Thr 
    1235                 1240                 1245             


Ala Val  Ser Gly His Ile 
    1250                 


<210>  94
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Asp Phe Ser Arg Leu His Met Tyr Ser Pro Pro Gln Cys Val Pro 
1               5                   10                  15      


Glu Asn Thr Gly Tyr Thr Tyr Ala Leu Ser Ser Ser Tyr Ser Ser Asp 
            20                  25                  30          


Ala Leu Asp Phe Glu Thr Glu His Lys Leu Asp Pro Val Phe Asp Ser 
        35                  40                  45              


Pro Arg Met Ser Arg Arg Ser Leu Arg Leu Ala Thr Thr Ala Cys Thr 
    50                  55                  60                  


Leu Gly Asp Gly Glu Ala Val Gly Ala Asp Ser Gly Thr Ser Ser Ala 
65                  70                  75                  80  


Val Ser Leu Lys Asn Arg Ala Ala Arg Thr Thr Lys Gln Arg Arg Ser 
                85                  90                  95      


Thr Asn Lys Ser Ala Phe Ser Ile Asn His Val Ser Arg Gln Val Thr 
            100                 105                 110         


Ser Ser Gly Val Ser His Gly Gly Thr Val Ser Leu Gln Asp Ala Val 
        115                 120                 125             


Thr Arg Arg Pro Pro Val Leu Asp Glu Ser 
    130                 135             


<210>  95
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  95

Cys Lys Gly Lys Arg His Leu Asp Ala His Pro Gly Arg Ala Gly Thr 
1               5                   10                  15      


Leu Trp His Ile Trp Ala Cys Ala Gly Tyr Phe Leu Leu Gln Ile Leu 
            20                  25                  30          


Arg Arg Ile Gly Ala Val Gly Gln Ala Val Ser Arg Thr Ala Trp Ser 
        35                  40                  45              


Ala Leu Trp Leu Ala Val Val Ala Pro Gly Lys Ala Ala Ser Gly Val 
    50                  55                  60                  


Phe Trp Trp Leu Gly Ile Gly Trp Tyr Gln Phe Val Thr Leu Ile Ser 
65                  70                  75                  80  


<210>  96
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Ser Arg Arg Ser Gln Arg Leu Thr Arg Tyr Ser Gln Gly Asp Asp 
1               5                   10                  15      


Asp Gly Ser Ser Ser Ser Gly Gly Ser Ser Val Ala Gly Ser Gln Ser 
            20                  25                  30          


Thr Leu Phe Lys Asp Ser Pro Leu Arg Thr Leu Lys Arg Lys Ser Ser 
        35                  40                  45              


Asn Met Lys Arg Leu Ser Pro Ala Pro Gln Leu Gly Pro Ser Ser Asp 
    50                  55                  60                  


Ala His Thr Ser Tyr Tyr Ser Glu Ser Leu Val His Glu Ser Trp Phe 
65                  70                  75                  80  


Pro Pro Arg Ser Ser Leu Glu Glu Leu His Gly Asp Ala Asn Trp Gly 
                85                  90                  95      


Glu Asp Leu Arg Val Arg Arg Arg Arg Gly Thr Gly Gly Ser Glu Ser 
            100                 105                 110         


Ser Arg Ala Ser Gly Leu Val Gly Arg Lys Ala Thr Glu Asp Phe Leu 
        115                 120                 125             


Gly Ser Ser Ser Gly Tyr Ser Ser Glu Asp Asp 
    130                 135                 


<210>  97
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  97

Arg Gly Phe Leu Phe Arg Val Leu Arg Ala Ala Leu Pro Leu Gln Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ile Gly Leu Ala Cys Leu Val Pro Met Ser Glu 
            20                  25                  30          


Glu Asp Tyr Ser Cys Ala Leu Ser Asn Asn Phe Ala Arg Ser Phe His 
        35                  40                  45              


Pro Met Leu Arg Tyr Thr Asn Gly Pro Pro Pro Leu 
    50                  55                  60  


<210>  98
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  98

Arg Ser Phe Leu Ser Arg Val Val Arg Ala Ala Leu Pro Leu Gln Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Ala Cys Leu Leu Pro Ser Ser Glu 
            20                  25                  30          


Glu Asp Tyr Ser Cys Thr Gln Ala Asn Asn Phe Ala Arg Ser Phe Tyr 
        35                  40                  45              


Pro Met Leu Arg Tyr Thr Asn Gly Pro Pro Pro Thr 
    50                  55                  60  


<210>  99
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  99

Gly Ser Leu Phe Arg Arg Ala Cys Cys Val Ala Leu Pro Leu Gln Leu 
1               5                   10                  15      


Leu Leu Leu Leu Phe Leu Leu Leu Leu Phe Leu Leu Pro Ile Arg Glu 
            20                  25                  30          


Glu Asp Arg Ser Cys Thr Leu Ala Asn Asn Phe Ala Arg Ser Phe Thr 
        35                  40                  45              


Leu Met Leu Arg Tyr Asn Gly Pro Pro Pro Thr 
    50                  55                  


<210>  100
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  100

Asp Pro Ala Ser Arg Gln Pro Leu Thr Phe Leu Leu Ile Leu Phe Leu 
1               5                   10                  15      


Leu Phe Leu Leu Leu Val Gly Ala Met Phe Leu Leu Pro Ala Ser Gly 
            20                  25                  30          


Gly Pro Cys Cys Ser His Ala Arg Ile Pro Arg Thr Pro Tyr Leu Val 
        35                  40                  45              


Leu Ser Tyr Val Asn Gly Leu Pro Pro Val 
    50                  55              


<210>  101
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  101

Leu Ile Pro Ala Pro Val Leu Gly Leu Leu Leu Leu Leu Leu Leu Ser 
1               5                   10                  15      


Val Leu Leu Leu Gly Pro Ser Pro Pro Pro Thr Trp Pro His Leu Gln 
            20                  25                  30          


Leu Cys Tyr Leu Gln Pro Pro Pro Val 
        35                  40      


<210>  102
<211>  8797
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ala Thr Ser Arg Gly Ala Ser Arg Cys Pro Arg Asp Ile Ala Asn 
1               5                   10                  15      


Val Met Gln Arg Leu Gln Asp Glu Gln Glu Ile Val Gln Lys Arg Thr 
            20                  25                  30          


Phe Thr Lys Trp Ile Asn Ser His Leu Ala Lys Arg Lys Pro Pro Met 
        35                  40                  45              


Val Val Asp Asp Leu Phe Glu Asp Met Lys Asp Gly Val Lys Leu Leu 
    50                  55                  60                  


Ala Leu Leu Glu Val Leu Ser Gly Gln Lys Leu Pro Cys Glu Gln Gly 
65                  70                  75                  80  


Arg Arg Met Lys Arg Ile His Ala Val Ala Asn Ile Gly Thr Ala Leu 
                85                  90                  95      


Lys Phe Leu Glu Gly Arg Lys Ile Lys Leu Val Asn Ile Asn Ser Thr 
            100                 105                 110         


Asp Ile Ala Asp Gly Arg Pro Ser Ile Val Leu Gly Leu Met Trp Thr 
        115                 120                 125             


Ile Ile Leu Tyr Phe Gln Ile Glu Glu Leu Thr Ser Asn Leu Pro Gln 
    130                 135                 140                 


Leu Gln Ser Leu Ser Ser Ser Ala Ser Ser Val Asp Ser Ile Val Ser 
145                 150                 155                 160 


Ser Glu Thr Pro Ser Pro Pro Ser Lys Arg Lys Val Thr Thr Lys Ile 
                165                 170                 175     


Gln Gly Asn Ala Lys Lys Ala Leu Leu Lys Trp Val Gln Tyr Thr Ala 
            180                 185                 190         


Gly Lys Gln Thr Gly Ile Glu Val Lys Asp Phe Gly Lys Ser Trp Arg 
        195                 200                 205             


Ser Gly Val Ala Phe His Ser Val Ile His Ala Ile Arg Pro Glu Leu 
    210                 215                 220                 


Val Asp Leu Glu Thr Val Lys Gly Arg Ser Asn Arg Glu Asn Leu Glu 
225                 230                 235                 240 


Asp Ala Phe Thr Ile Ala Glu Thr Glu Leu Gly Ile Pro Arg Leu Leu 
                245                 250                 255     


Asp Pro Glu Asp Val Asp Val Asp Lys Pro Asp Glu Lys Ser Ile Met 
            260                 265                 270         


Thr Tyr Val Ala Gln Phe Leu Lys His Tyr Pro Asp Ile His Asn Ala 
        275                 280                 285             


Ser Thr Asp Gly Gln Glu Asp Asp Glu Ile Leu Pro Gly Phe Pro Ser 
    290                 295                 300                 


Phe Ala Asn Ser Val Gln Asn Phe Lys Arg Glu Asp Arg Val Ile Phe 
305                 310                 315                 320 


Lys Glu Met Lys Val Trp Ile Glu Gln Phe Glu Arg Asp Leu Thr Arg 
                325                 330                 335     


Ala Gln Met Val Glu Ser Asn Leu Gln Asp Lys Tyr Gln Ser Phe Lys 
            340                 345                 350         


His Phe Arg Val Gln Tyr Glu Met Lys Arg Lys Gln Ile Glu His Leu 
        355                 360                 365             


Ile Gln Pro Leu His Arg Asp Gly Lys Leu Ser Leu Asp Gln Ala Leu 
    370                 375                 380                 


Val Lys Gln Ser Trp Asp Arg Val Thr Ser Arg Leu Phe Asp Trp His 
385                 390                 395                 400 


Ile Gln Leu Asp Lys Ser Leu Pro Ala Pro Leu Gly Thr Ile Gly Ala 
                405                 410                 415     


Trp Leu Tyr Arg Ala Glu Val Ala Leu Arg Glu Glu Ile Thr Val Gln 
            420                 425                 430         


Gln Val His Glu Glu Thr Ala Asn Thr Ile Gln Arg Lys Leu Glu Gln 
        435                 440                 445             


His Lys Asp Leu Leu Gln Asn Thr Asp Ala His Lys Arg Ala Phe His 
    450                 455                 460                 


Glu Ile Tyr Arg Thr Arg Ser Val Asn Gly Ile Pro Val Pro Pro Asp 
465                 470                 475                 480 


Gln Leu Glu Asp Met Ala Glu Arg Phe His Phe Val Ser Ser Thr Ser 
                485                 490                 495     


Glu Leu His Leu Met Lys Met Glu Phe Leu Glu Leu Lys Tyr Arg Leu 
            500                 505                 510         


Leu Ser Leu Leu Val Leu Ala Glu Ser Lys Leu Lys Ser Trp Ile Ile 
        515                 520                 525             


Lys Tyr Gly Arg Arg Glu Ser Val Glu Gln Leu Leu Gln Asn Tyr Val 
    530                 535                 540                 


Ser Phe Ile Glu Asn Ser Lys Phe Phe Glu Gln Tyr Glu Val Thr Tyr 
545                 550                 555                 560 


Gln Ile Leu Lys Gln Thr Ala Glu Met Tyr Val Lys Ala Asp Gly Ser 
                565                 570                 575     


Val Glu Glu Ala Glu Asn Val Met Lys Phe Met Asn Glu Thr Thr Ala 
            580                 585                 590         


Gln Trp Arg Asn Leu Ser Val Glu Val Arg Ser Val Arg Ser Met Leu 
        595                 600                 605             


Glu Glu Val Ile Ser Asn Trp Asp Arg Tyr Gly Asn Thr Val Ala Ser 
    610                 615                 620                 


Leu Gln Ala Trp Leu Glu Asp Ala Glu Lys Met Leu Asn Gln Ser Glu 
625                 630                 635                 640 


Asn Ala Lys Lys Asp Phe Phe Arg Asn Leu Pro His Trp Ile Gln Gln 
                645                 650                 655     


His Thr Ala Met Asn Asp Ala Gly Asn Phe Leu Ile Glu Thr Cys Asp 
            660                 665                 670         


Glu Met Val Ser Arg Asp Leu Lys Gln Gln Leu Leu Leu Leu Asn Gly 
        675                 680                 685             


Arg Trp Arg Glu Leu Phe Met Glu Val Lys Gln Tyr Ala Gln Ala Asp 
    690                 695                 700                 


Glu Met Asp Arg Met Lys Lys Glu Tyr Thr Asp Cys Val Val Thr Leu 
705                 710                 715                 720 


Ser Ala Phe Ala Thr Glu Ala His Lys Lys Leu Ser Glu Pro Leu Glu 
                725                 730                 735     


Val Ser Phe Met Asn Val Lys Leu Leu Ile Gln Asp Leu Glu Asp Ile 
            740                 745                 750         


Glu Gln Arg Val Pro Val Met Asp Ala Gln Tyr Lys Ile Ile Thr Lys 
        755                 760                 765             


Thr Ala His Leu Ile Thr Lys Glu Ser Pro Gln Glu Glu Gly Lys Glu 
    770                 775                 780                 


Met Phe Ala Thr Met Ser Lys Leu Lys Glu Gln Leu Thr Lys Val Lys 
785                 790                 795                 800 


Glu Cys Tyr Ser Pro Leu Leu Tyr Glu Ser Gln Gln Leu Leu Ile Pro 
                805                 810                 815     


Leu Glu Glu Leu Glu Lys Gln Met Thr Ser Phe Tyr Asp Ser Leu Gly 
            820                 825                 830         


Lys Ile Asn Glu Ile Ile Thr Val Leu Glu Arg Glu Ala Gln Ser Ser 
        835                 840                 845             


Ala Leu Phe Lys Gln Lys His Gln Glu Leu Leu Ala Cys Gln Glu Asn 
    850                 855                 860                 


Cys Lys Lys Thr Leu Thr Leu Ile Glu Lys Gly Ser Gln Ser Val Gln 
865                 870                 875                 880 


Lys Phe Val Thr Leu Ser Asn Val Leu Lys His Phe Asp Gln Thr Arg 
                885                 890                 895     


Leu Gln Arg Gln Ile Ala Asp Ile His Val Ala Phe Gln Ser Met Val 
            900                 905                 910         


Lys Lys Thr Gly Asp Trp Lys Lys His Val Glu Thr Asn Ser Arg Leu 
        915                 920                 925             


Met Lys Lys Phe Glu Glu Ser Arg Ala Glu Leu Glu Lys Val Leu Arg 
    930                 935                 940                 


Ile Ala Gln Glu Gly Leu Glu Glu Lys Gly Asp Pro Glu Glu Leu Leu 
945                 950                 955                 960 


Arg Arg His Thr Glu Phe Phe Ser Gln Leu Asp Gln Arg Val Leu Asn 
                965                 970                 975     


Ala Phe Leu Lys Ala Cys Asp Glu Leu Thr Asp Ile Leu Pro Glu Gln 
            980                 985                 990         


Glu Gln Gln Gly Leu Gln Glu Ala  Val Arg Lys Leu His  Lys Gln Trp 
        995                 1000                 1005             


Lys Asp  Leu Gln Gly Glu Ala  Pro Tyr His Leu Leu  His Leu Lys 
    1010                 1015                 1020             


Ile Asp  Val Glu Lys Asn Arg  Phe Leu Ala Ser Val  Glu Glu Cys 
    1025                 1030                 1035             


Arg Thr  Glu Leu Asp Arg Glu  Thr Lys Leu Met Pro  Gln Glu Gly 
    1040                 1045                 1050             


Ser Glu  Lys Ile Ile Lys Glu  His Arg Val Phe Phe  Ser Asp Lys 
    1055                 1060                 1065             


Gly Pro  His His Leu Cys Glu  Lys Arg Leu Gln Leu  Ile Glu Glu 
    1070                 1075                 1080             


Leu Cys  Val Lys Leu Pro Val  Arg Asp Pro Val Arg  Asp Thr Pro 
    1085                 1090                 1095             


Gly Thr  Cys His Val Thr Leu  Lys Glu Leu Arg Ala  Ala Ile Asp 
    1100                 1105                 1110             


Ser Thr  Tyr Arg Lys Leu Met  Glu Asp Pro Asp Lys  Trp Lys Asp 
    1115                 1120                 1125             


Tyr Thr  Ser Arg Phe Ser Glu  Phe Ser Ser Trp Ile  Ser Thr Asn 
    1130                 1135                 1140             


Glu Thr  Gln Leu Lys Gly Ile  Lys Gly Glu Ala Ile  Asp Thr Ala 
    1145                 1150                 1155             


Asn His  Gly Glu Val Lys Arg  Ala Val Glu Glu Ile  Arg Asn Gly 
    1160                 1165                 1170             


Val Thr  Lys Arg Gly Glu Thr  Leu Ser Trp Leu Lys  Ser Arg Leu 
    1175                 1180                 1185             


Lys Val  Leu Thr Glu Val Ser  Ser Glu Asn Glu Ala  Gln Lys Gln 
    1190                 1195                 1200             


Gly Asp  Glu Leu Ala Lys Leu  Ser Ser Ser Phe Lys  Ala Leu Val 
    1205                 1210                 1215             


Thr Leu  Leu Ser Glu Val Glu  Lys Met Leu Ser Asn  Phe Gly Asp 
    1220                 1225                 1230             


Cys Val  Gln Tyr Lys Glu Ile  Val Lys Asn Ser Leu  Glu Glu Leu 
    1235                 1240                 1245             


Ile Ser  Gly Ser Lys Glu Val  Gln Glu Gln Ala Glu  Lys Ile Leu 
    1250                 1255                 1260             


Asp Thr  Glu Asn Leu Phe Glu  Ala Gln Gln Leu Leu  Leu His His 
    1265                 1270                 1275             


Gln Gln  Lys Thr Lys Arg Ile  Ser Ala Lys Lys Arg  Asp Val Gln 
    1280                 1285                 1290             


Gln Gln  Ile Ala Gln Ala Gln  Gln Gly Glu Gly Gly  Leu Pro Asp 
    1295                 1300                 1305             


Arg Gly  His Glu Glu Leu Arg  Lys Leu Glu Ser Thr  Leu Asp Gly 
    1310                 1315                 1320             


Leu Glu  Arg Ser Arg Glu Arg  Gln Glu Arg Arg Ile  Gln Val Thr 
    1325                 1330                 1335             


Leu Arg  Lys Trp Glu Arg Phe  Glu Thr Asn Lys Glu  Thr Val Val 
    1340                 1345                 1350             


Arg Tyr  Leu Phe Gln Thr Gly  Ser Ser His Glu Arg  Phe Leu Ser 
    1355                 1360                 1365             


Phe Ser  Ser Leu Glu Ser Leu  Ser Ser Glu Leu Glu  Gln Thr Lys 
    1370                 1375                 1380             


Glu Phe  Ser Lys Arg Thr Glu  Ser Ile Ala Val Gln  Ala Glu Asn 
    1385                 1390                 1395             


Leu Val  Lys Glu Ala Ser Glu  Ile Pro Leu Gly Pro  Gln Asn Lys 
    1400                 1405                 1410             


Gln Leu  Leu Gln Gln Gln Ala  Lys Ser Ile Lys Glu  Gln Val Lys 
    1415                 1420                 1425             


Lys Leu  Glu Asp Thr Leu Glu  Glu Asp Ile Lys Thr  Met Glu Met 
    1430                 1435                 1440             


Val Lys  Thr Lys Trp Asp His  Phe Gly Ser Asn Phe  Glu Thr Leu 
    1445                 1450                 1455             


Ser Val  Trp Ile Thr Glu Lys  Glu Lys Glu Leu Asn  Ala Leu Glu 
    1460                 1465                 1470             


Thr Ser  Ser Ser Ala Met Asp  Met Gln Ile Ser Gln  Ile Lys Val 
    1475                 1480                 1485             


Thr Ile  Gln Glu Ile Glu Ser  Lys Leu Ser Ser Ile  Val Gly Leu 
    1490                 1495                 1500             


Glu Glu  Glu Ala Gln Ser Phe  Ala Gln Phe Val Thr  Thr Gly Glu 
    1505                 1510                 1515             


Ser Ala  Arg Ile Lys Ala Lys  Leu Thr Gln Ile Arg  Arg Tyr Gly 
    1520                 1525                 1530             


Glu Glu  Leu Arg Glu His Ala  Gln Cys Leu Glu Gly  Thr Ile Leu 
    1535                 1540                 1545             


Gly His  Leu Ser Gln Gln Gln  Lys Phe Glu Glu Asn  Leu Arg Lys 
    1550                 1555                 1560             


Ile Gln  Gln Ser Val Ser Glu  Phe Glu Asp Lys Leu  Ala Val Pro 
    1565                 1570                 1575             


Ile Lys  Ile Cys Ser Ser Ala  Thr Glu Thr Tyr Lys  Val Leu Gln 
    1580                 1585                 1590             


Glu His  Met Asp Leu Cys Gln  Ala Leu Glu Ser Leu  Ser Ser Ala 
    1595                 1600                 1605             


Ile Thr  Ala Phe Ser Ala Ser  Ala Arg Lys Val Val  Asn Arg Asp 
    1610                 1615                 1620             


Ser Cys  Val Gln Glu Ala Ala  Ala Leu Gln Gln Gln  Tyr Glu Asp 
    1625                 1630                 1635             


Ile Leu  Arg Arg Ala Lys Glu  Arg Gln Thr Ala Leu  Glu Asn Leu 
    1640                 1645                 1650             


Leu Ala  His Trp Gln Arg Leu  Glu Lys Glu Leu Ser  Ser Phe Leu 
    1655                 1660                 1665             


Thr Trp  Leu Glu Arg Gly Glu  Ala Lys Ala Ser Ser  Pro Glu Met 
    1670                 1675                 1680             


Asp Ile  Ser Ala Asp Arg Val  Lys Val Glu Gly Glu  Leu Gln Leu 
    1685                 1690                 1695             


Ile Gln  Ala Leu Gln Asn Glu  Val Val Ser Gln Ala  Ser Phe Tyr 
    1700                 1705                 1710             


Ser Lys  Leu Leu Gln Leu Lys  Glu Ser Leu Phe Ser  Val Ala Ser 
    1715                 1720                 1725             


Lys Asp  Asp Val Lys Met Met  Lys Leu His Leu Glu  Gln Leu Asp 
    1730                 1735                 1740             


Glu Arg  Trp Arg Asp Leu Pro  Gln Ile Ile Asn Lys  Arg Ile Asn 
    1745                 1750                 1755             


Phe Leu  Gln Ser Val Val Ala  Glu His Gln Gln Phe  Asp Glu Leu 
    1760                 1765                 1770             


Leu Leu  Ser Phe Ser Val Trp  Ile Lys Leu Phe Leu  Ser Glu Leu 
    1775                 1780                 1785             


Gln Thr  Thr Ser Glu Ile Ser  Ile Met Asp His Gln  Val Ala Leu 
    1790                 1795                 1800             


Thr Arg  His Lys Asp His Ala  Ala Glu Val Glu Ser  Lys Lys Gly 
    1805                 1810                 1815             


Glu Leu  Gln Ser Leu Gln Gly  His Leu Ala Lys Leu  Gly Ser Leu 
    1820                 1825                 1830             


Gly Arg  Ala Glu Asp Leu His  Leu Leu Gln Gly Lys  Ala Glu Asp 
    1835                 1840                 1845             


Cys Phe  Gln Leu Phe Glu Glu  Ala Ser Gln Val Val  Glu Arg Arg 
    1850                 1855                 1860             


Gln Leu  Ala Leu Ser His Leu  Ala Glu Phe Leu Gln  Ser His Ala 
    1865                 1870                 1875             


Ser Leu  Ser Gly Ile Leu Arg  Gln Leu Arg Gln Thr  Val Glu Ala 
    1880                 1885                 1890             


Thr Asn  Ser Met Asn Lys Asn  Glu Ser Asp Leu Ile  Glu Lys Asp 
    1895                 1900                 1905             


Leu Asn  Asp Ala Leu Gln Asn  Ala Lys Ala Leu Glu  Ser Ala Ala 
    1910                 1915                 1920             


Val Ser  Leu Asp Gly Ile Leu  Ser Lys Ala Gln Tyr  His Leu Lys 
    1925                 1930                 1935             


Ile Gly  Ser Ser Glu Gln Arg  Thr Ser Cys Arg Ala  Thr Ala Asp 
    1940                 1945                 1950             


Gln Leu  Cys Gly Glu Val Glu  Arg Ile Gln Asn Leu  Leu Gly Thr 
    1955                 1960                 1965             


Lys Gln  Ser Glu Ala Asp Ala  Leu Ala Val Leu Lys  Lys Ala Phe 
    1970                 1975                 1980             


Gln Asp  Gln Lys Glu Glu Leu  Leu Lys Ser Ile Glu  Asp Ile Glu 
    1985                 1990                 1995             


Glu Arg  Thr Asp Lys Glu Arg  Leu Lys Glu Pro Thr  Arg Gln Ala 
    2000                 2005                 2010             


Leu Gln  Gln Arg Leu Arg Val  Phe Asn Gln Leu Glu  Asp Glu Leu 
    2015                 2020                 2025             


Asn Ser  His Glu His Glu Leu  Cys Trp Leu Lys Asp  Lys Ala Lys 
    2030                 2035                 2040             


Gln Ile  Ala Gln Lys Asp Val  Ala Phe Ala Pro Glu  Val Asp Arg 
    2045                 2050                 2055             


Glu Ile  Asn Arg Leu Glu Val  Thr Trp Asp Asp Thr  Lys Arg Leu 
    2060                 2065                 2070             


Ile His  Glu Asn Gln Gly Gln  Cys Cys Gly Leu Ile  Asp Leu Met 
    2075                 2080                 2085             


Arg Glu  Tyr Gln Asn Leu Lys  Ser Ala Val Ser Lys  Val Leu Glu 
    2090                 2095                 2100             


Asn Ala  Ser Ser Val Ile Val  Thr Arg Thr Thr Ile  Lys Asp Gln 
    2105                 2110                 2115             


Glu Asp  Leu Lys Trp Ala Phe  Ser Lys His Glu Thr  Ala Lys Asn 
    2120                 2125                 2130             


Lys Met  Asn Tyr Lys Gln Lys  Asp Leu Asp Asn Phe  Thr Ser Lys 
    2135                 2140                 2145             


Gly Lys  His Leu Leu Ser Glu  Leu Lys Lys Ile His  Ser Ser Asp 
    2150                 2155                 2160             


Phe Ser  Leu Val Lys Thr Asp  Met Glu Ser Thr Val  Asp Lys Trp 
    2165                 2170                 2175             


Leu Asp  Val Ser Glu Lys Leu  Glu Glu Asn Met Asp  Arg Leu Arg 
    2180                 2185                 2190             


Val Ser  Leu Ser Ile Trp Asp  Asp Val Leu Ser Thr  Arg Asp Glu 
    2195                 2200                 2205             


Ile Glu  Gly Trp Ser Asn Asn  Cys Val Pro Gln Met  Ala Glu Asn 
    2210                 2215                 2220             


Ile Ser  Asn Leu Asp Asn His  Leu Arg Ala Glu Glu  Leu Leu Lys 
    2225                 2230                 2235             


Glu Phe  Glu Ser Glu Val Lys  Asn Lys Ala Leu Arg  Leu Glu Glu 
    2240                 2245                 2250             


Leu His  Ser Lys Val Asn Asp  Leu Lys Glu Leu Thr  Lys Asn Leu 
    2255                 2260                 2265             


Glu Thr  Pro Pro Asp Leu Gln  Phe Ile Glu Ala Asp  Leu Met Gln 
    2270                 2275                 2280             


Lys Leu  Glu His Ala Lys Glu  Ile Thr Glu Val Ala  Lys Gly Thr 
    2285                 2290                 2295             


Leu Lys  Asp Phe Thr Ala Gln  Ser Thr Gln Val Glu  Lys Phe Ile 
    2300                 2305                 2310             


Asn Asp  Ile Thr Thr Trp Phe  Thr Lys Val Glu Glu  Ser Leu Met 
    2315                 2320                 2325             


Asn Cys  Ala Gln Asn Glu Thr  Cys Glu Ala Leu Lys  Lys Val Lys 
    2330                 2335                 2340             


Asp Ile  Gln Lys Glu Leu Gln  Ser Gln Gln Ser Asn  Ile Ser Ser 
    2345                 2350                 2355             


Thr Gln  Glu Asn Leu Asn Ser  Leu Cys Arg Lys Tyr  His Ser Ala 
    2360                 2365                 2370             


Glu Leu  Glu Ser Leu Gly Arg  Ala Met Thr Gly Leu  Ile Lys Lys 
    2375                 2380                 2385             


His Glu  Ala Val Ser Gln Leu  Cys Ser Lys Thr Gln  Ala Ser Leu 
    2390                 2395                 2400             


Gln Glu  Ser Leu Glu Lys His  Phe Ser Glu Ser Met  Gln Glu Phe 
    2405                 2410                 2415             


Gln Glu  Trp Phe Leu Gly Ala  Lys Ala Ala Ala Lys  Glu Ser Ser 
    2420                 2425                 2430             


Asp Arg  Thr Gly Asp Ser Lys  Val Leu Glu Ala Lys  Leu His Asp 
    2435                 2440                 2445             


Leu Gln  Asn Ile Leu Asp Ser  Val Ser Asp Gly Gln  Ser Lys Leu 
    2450                 2455                 2460             


Asp Ala  Val Thr Gln Glu Gly  Gln Thr Leu Tyr Ala  His Leu Ser 
    2465                 2470                 2475             


Lys Gln  Ile Val Ser Ser Ile  Gln Glu Gln Ile Thr  Lys Ala Asn 
    2480                 2485                 2490             


Glu Glu  Phe Gln Ala Phe Leu  Lys Gln Cys Leu Lys  Asp Lys Gln 
    2495                 2500                 2505             


Ala Leu  Gln Asp Cys Ala Ser  Glu Leu Gly Ser Phe  Glu Asp Gln 
    2510                 2515                 2520             


His Arg  Lys Leu Asn Leu Trp  Ile His Glu Met Glu  Glu Arg Phe 
    2525                 2530                 2535             


Asn Thr  Glu Asn Leu Gly Glu  Ser Lys Gln His Ile  Pro Glu Lys 
    2540                 2545                 2550             


Lys Asn  Glu Val His Lys Val  Glu Met Phe Leu Gly  Glu Leu Leu 
    2555                 2560                 2565             


Ala Ala  Arg Glu Ser Leu Asp  Lys Leu Ser Gln Arg  Gly Gln Leu 
    2570                 2575                 2580             


Leu Ser  Glu Glu Gly His Gly  Ala Gly Gln Glu Gly  Arg Leu Cys 
    2585                 2590                 2595             


Ser Gln  Leu Leu Thr Ser His  Gln Asn Leu Leu Arg  Met Thr Lys 
    2600                 2605                 2610             


Glu Lys  Leu Arg Ser Cys Gln  Val Ala Leu Gln Glu  His Glu Ala 
    2615                 2620                 2625             


Leu Glu  Glu Ala Leu Gln Ser  Met Trp Phe Trp Val  Lys Ala Ile 
    2630                 2635                 2640             


Gln Asp  Arg Leu Ala Cys Ala  Glu Ser Thr Leu Gly  Ser Lys Asp 
    2645                 2650                 2655             


Thr Leu  Glu Lys Arg Leu Ser  Gln Ile Gln Asp Ile  Leu Leu Met 
    2660                 2665                 2670             


Lys Gly  Glu Gly Glu Val Lys  Leu Asn Met Ala Ile  Gly Lys Gly 
    2675                 2680                 2685             


Glu Gln  Ala Leu Arg Ser Ser  Asn Lys Glu Gly Gln  Arg Val Ile 
    2690                 2695                 2700             


Gln Thr  Gln Leu Glu Thr Leu  Lys Glu Val Trp Ala  Asp Ile Met 
    2705                 2710                 2715             


Ser Ser  Ser Val His Ala Gln  Ser Thr Leu Glu Ser  Val Ile Ser 
    2720                 2725                 2730             


Gln Trp  Asn Asp Tyr Val Glu  Arg Lys Asn Gln Leu  Glu Gln Trp 
    2735                 2740                 2745             


Met Glu  Ser Val Asp Gln Lys  Ile Glu His Pro Leu  Gln Pro Gln 
    2750                 2755                 2760             


Pro Gly  Leu Lys Glu Lys Phe  Val Leu Leu Asp His  Leu Gln Ser 
    2765                 2770                 2775             


Ile Leu  Ser Glu Ala Glu Asp  His Thr Arg Ala Leu  His Arg Leu 
    2780                 2785                 2790             


Ile Ala  Lys Ser Arg Glu Leu  Tyr Glu Lys Thr Glu  Asp Glu Ser 
    2795                 2800                 2805             


Phe Lys  Asp Thr Ala Gln Glu  Glu Leu Lys Thr Gln  Phe Asn Asp 
    2810                 2815                 2820             


Ile Met  Thr Val Ala Lys Glu  Lys Met Arg Lys Val  Glu Glu Ile 
    2825                 2830                 2835             


Val Lys  Asp His Leu Met Tyr  Leu Asp Ala Val His  Glu Phe Thr 
    2840                 2845                 2850             


Asp Trp  Leu His Ser Ala Lys  Glu Glu Leu His Arg  Trp Ser Asp 
    2855                 2860                 2865             


Met Ser  Gly Asp Ser Ser Ala  Thr Gln Lys Lys Leu  Ser Lys Ile 
    2870                 2875                 2880             


Lys Glu  Leu Ile Asp Ser Arg  Glu Ile Gly Ala Ser  Arg Leu Ser 
    2885                 2890                 2895             


Arg Val  Glu Ser Leu Ala Pro  Glu Val Lys Gln Asn  Thr Thr Ala 
    2900                 2905                 2910             


Ser Gly  Cys Glu Leu Met His  Thr Glu Met Gln Ala  Leu Arg Ala 
    2915                 2920                 2925             


Asp Trp  Lys Gln Trp Glu Asp  Ser Val Phe Gln Thr  Gln Ser Cys 
    2930                 2935                 2940             


Leu Glu  Asn Leu Val Ser Gln  Met Ala Leu Ser Glu  Gln Glu Phe 
    2945                 2950                 2955             


Ser Gly  Gln Val Ala Gln Leu  Glu Gln Ala Leu Glu  Gln Phe Ser 
    2960                 2965                 2970             


Ala Leu  Leu Lys Thr Trp Ala  Gln Gln Leu Thr Leu  Leu Glu Gly 
    2975                 2980                 2985             


Lys Asn  Thr Asp Glu Glu Ile  Val Glu Cys Trp His  Lys Gly Gln 
    2990                 2995                 3000             


Glu Ile  Leu Asp Ala Leu Gln  Lys Ala Glu Pro Arg  Thr Glu Asp 
    3005                 3010                 3015             


Leu Lys  Ser Gln Leu Asn Glu  Leu Cys Arg Phe Ser  Arg Asp Leu 
    3020                 3025                 3030             


Ser Thr  Tyr Ser Gly Lys Val  Ser Gly Leu Ile Lys  Glu Tyr Asn 
    3035                 3040                 3045             


Cys Leu  Cys Leu Gln Ala Ser  Lys Gly Cys Gln Asn  Lys Glu Gln 
    3050                 3055                 3060             


Ile Leu  Gln Gln Arg Phe Arg  Lys Ala Phe Arg Asp  Phe Gln Gln 
    3065                 3070                 3075             


Trp Leu  Val Asn Ala Lys Ile  Thr Thr Ala Lys Cys  Phe Asp Ile 
    3080                 3085                 3090             


Pro Gln  Asn Ile Ser Glu Val  Ser Thr Ser Leu Gln  Lys Ile Gln 
    3095                 3100                 3105             


Glu Phe  Leu Ser Glu Ser Glu  Asn Gly Gln His Lys  Leu Asn Met 
    3110                 3115                 3120             


Met Leu  Ser Lys Gly Glu Leu  Leu Ser Thr Leu Leu  Thr Lys Glu 
    3125                 3130                 3135             


Lys Ala  Lys Gly Ile Gln Ala  Lys Val Thr Ala Ala  Lys Glu Asp 
    3140                 3145                 3150             


Trp Lys  Asn Phe His Ser Asn  Leu His Gln Lys Glu  Ser Ala Leu 
    3155                 3160                 3165             


Glu Asn  Leu Lys Ile Gln Met  Lys Asp Phe Glu Val  Ser Ala Glu 
    3170                 3175                 3180             


Pro Ile  Gln Asp Trp Leu Ser  Lys Thr Glu Lys Met  Val His Glu 
    3185                 3190                 3195             


Ser Ser  Asn Arg Leu Tyr Asp  Leu Pro Ala Lys Arg  Arg Glu Gln 
    3200                 3205                 3210             


Gln Lys  Leu Gln Ser Val Leu  Glu Glu Ile His Cys  Tyr Glu Pro 
    3215                 3220                 3225             


Gln Leu  Asn Arg Leu Lys Glu  Lys Ala Gln Gln Leu  Trp Glu Gly 
    3230                 3235                 3240             


Gln Ala  Ala Ser Lys Ser Phe  Arg His Arg Val Ser  Gln Leu Ser 
    3245                 3250                 3255             


Ser Gln  Tyr Leu Ala Leu Ser  Asn Leu Thr Lys Glu  Lys Val Ser 
    3260                 3265                 3270             


Arg Leu  Asp Arg Ile Val Ala  Glu His Asn Gln Phe  Ser Leu Gly 
    3275                 3280                 3285             


Ile Lys  Glu Leu Gln Asp Trp  Met Thr Asp Ala Ile  His Met Leu 
    3290                 3295                 3300             


Asp Ser  Tyr Cys His Pro Thr  Ser Asp Lys Ser Val  Leu Asp Ser 
    3305                 3310                 3315             


Arg Thr  Leu Lys Leu Glu Ala  Leu Leu Ser Val Lys  Gln Glu Lys 
    3320                 3325                 3330             


Glu Ile  Gln Met Lys Met Ile  Val Thr Arg Gly Glu  Ser Val Leu 
    3335                 3340                 3345             


Gln Asn  Thr Ser Pro Glu Gly  Ile Pro Thr Ile Gln  Gln Gln Leu 
    3350                 3355                 3360             


Gln Ser  Val Lys Asp Met Trp  Ala Ser Leu Leu Ser  Ala Gly Ile 
    3365                 3370                 3375             


Arg Cys  Lys Ser Gln Leu Glu  Gly Ala Leu Ser Lys  Trp Thr Ser 
    3380                 3385                 3390             


Tyr Gln  Asp Gly Val Arg Gln  Phe Ser Gly Trp Met  Asp Ser Met 
    3395                 3400                 3405             


Glu Ala  Asn Leu Asn Glu Ser  Glu Arg Gln His Ala  Glu Leu Arg 
    3410                 3415                 3420             


Asp Lys  Thr Thr Met Leu Gly  Lys Ala Lys Leu Leu  Asn Glu Glu 
    3425                 3430                 3435             


Val Leu  Ser Tyr Ser Ser Leu  Leu Glu Thr Ile Glu  Val Lys Gly 
    3440                 3445                 3450             


Ala Gly  Met Thr Glu His Tyr  Val Thr Gln Leu Glu  Leu Gln Asp 
    3455                 3460                 3465             


Leu Gln  Glu Arg Tyr Arg Ala  Ile Gln Glu Arg Ala  Lys Glu Ala 
    3470                 3475                 3480             


Val Thr  Lys Ser Glu Lys Leu  Val Arg Leu His Gln  Glu Tyr Gln 
    3485                 3490                 3495             


Arg Asp  Leu Lys Ala Phe Glu  Val Trp Leu Gly Gln  Glu Gln Glu 
    3500                 3505                 3510             


Lys Leu  Asp Gln Tyr Ser Val  Leu Glu Gly Asp Ala  His Thr His 
    3515                 3520                 3525             


Glu Thr  Thr Leu Arg Asp Leu  Gln Glu Leu Gln Val  His Cys Ala 
    3530                 3535                 3540             


Glu Gly  Gln Ala Leu Leu Asn  Ser Val Leu His Thr  Arg Glu Asp 
    3545                 3550                 3555             


Val Ile  Pro Ser Gly Ile Pro  Gln Ala Glu Asp Arg  Ala Leu Glu 
    3560                 3565                 3570             


Ser Leu  Arg Gln Asp Trp Gln  Ala Tyr Gln His Arg  Leu Ser Glu 
    3575                 3580                 3585             


Thr Arg  Thr Gln Phe Asn Asn  Val Val Asn Lys Leu  Arg Leu Met 
    3590                 3595                 3600             


Glu Gln  Lys Phe Gln Gln Val  Asp Glu Trp Leu Lys  Thr Ala Glu 
    3605                 3610                 3615             


Glu Lys  Val Ser Pro Arg Thr  Arg Arg Gln Ser Asn  Arg Ala Thr 
    3620                 3625                 3630             


Lys Glu  Ile Gln Leu His Gln  Met Lys Lys Trp His  Glu Glu Val 
    3635                 3640                 3645             


Thr Ala  Tyr Arg Asp Glu Val  Glu Glu Val Gly Ala  Arg Ala Gln 
    3650                 3655                 3660             


Glu Ile  Leu Asp Glu Ser His  Val Asn Ser Arg Met  Gly Cys Gln 
    3665                 3670                 3675             


Ala Thr  Gln Leu Thr Ser Arg  Tyr Gln Ala Leu Leu  Leu Gln Val 
    3680                 3685                 3690             


Leu Glu  Gln Ile Lys Phe Leu  Glu Glu Glu Ile Gln  Ser Leu Glu 
    3695                 3700                 3705             


Glu Ser  Glu Ser Ser Leu Ser  Ser Tyr Ser Asp Trp  Tyr Gly Ser 
    3710                 3715                 3720             


Thr His  Lys Asn Phe Lys Asn  Val Ala Thr Lys Ile  Asp Lys Val 
    3725                 3730                 3735             


Asp Thr  Val Met Met Gly Lys  Lys Leu Lys Thr Leu  Glu Val Leu 
    3740                 3745                 3750             


Leu Lys  Asp Met Glu Lys Gly  His Ser Leu Leu Lys  Ser Ala Arg 
    3755                 3760                 3765             


Glu Lys  Gly Glu Arg Ala Val  Lys Tyr Leu Glu Glu  Gly Glu Ala 
    3770                 3775                 3780             


Glu Arg  Leu Arg Lys Glu Ile  His Asp His Met Glu  Gln Leu Lys 
    3785                 3790                 3795             


Glu Leu  Thr Ser Thr Val Arg  Lys Glu His Met Thr  Leu Glu Lys 
    3800                 3805                 3810             


Gly Leu  His Leu Ala Lys Glu  Phe Ser Asp Lys Cys  Lys Ala Leu 
    3815                 3820                 3825             


Thr Gln  Trp Ile Ala Glu Tyr  Gln Glu Ile Leu His  Val Pro Glu 
    3830                 3835                 3840             


Glu Pro  Lys Met Glu Leu Tyr  Glu Lys Lys Ala Gln  Leu Ser Lys 
    3845                 3850                 3855             


Tyr Lys  Ser Leu Gln Gln Thr  Val Leu Ser His Glu  Pro Ser Val 
    3860                 3865                 3870             


Lys Ser  Val Arg Glu Lys Gly  Glu Ala Leu Leu Glu  Leu Val Gln 
    3875                 3880                 3885             


Asp Val  Thr Leu Lys Asp Lys  Ile Asp Gln Leu Gln  Ser Asp Tyr 
    3890                 3895                 3900             


Gln Asp  Leu Cys Ser Ile Gly  Lys Glu His Val Phe  Ser Leu Glu 
    3905                 3910                 3915             


Ala Lys  Val Lys Asp His Glu  Asp Tyr Asn Ser Glu  Leu Gln Glu 
    3920                 3925                 3930             


Val Glu  Lys Trp Leu Leu Gln  Met Ser Gly Arg Leu  Val Ala Pro 
    3935                 3940                 3945             


Asp Leu  Leu Glu Thr Ser Ser  Leu Glu Thr Ile Thr  Gln Gln Leu 
    3950                 3955                 3960             


Ala His  His Lys Ala Met Met  Glu Glu Ile Ala Gly  Phe Glu Asp 
    3965                 3970                 3975             


Arg Leu  Asn Asn Leu Gln Met  Lys Gly Asp Thr Leu  Ile Gly Gln 
    3980                 3985                 3990             


Cys Ala  Asp His Leu Gln Ala  Lys Leu Lys Gln Asn  Val His Ala 
    3995                 4000                 4005             


His Leu  Gln Gly Thr Lys Asp  Ser Tyr Ser Ala Ile  Cys Ser Thr 
    4010                 4015                 4020             


Ala Gln  Arg Met Tyr Gln Ser  Leu Glu His Glu Leu  Gln Lys His 
    4025                 4030                 4035             


Val Ser  Arg Gln Asp Thr Leu  Gln Gln Cys Gln Ala  Trp Leu Ser 
    4040                 4045                 4050             


Ala Val  Gln Pro Asp Leu Glu  Pro Ser Pro Gln Pro  Pro Leu Ser 
    4055                 4060                 4065             


Arg Ala  Glu Ala Ile Lys Gln  Val Lys His Phe Arg  Ala Leu Gln 
    4070                 4075                 4080             


Glu Gln  Ala Arg Thr Tyr Leu  Asp Leu Leu Cys Ser  Met Cys Asp 
    4085                 4090                 4095             


Leu Ser  Asn Ala Ser Val Lys  Thr Thr Ala Lys Asp  Ile Gln Gln 
    4100                 4105                 4110             


Thr Glu  Gln Thr Ile Glu Gln  Lys Leu Val Gln Ala  Gln Asn Leu 
    4115                 4120                 4125             


Thr Gln  Gly Trp Glu Glu Ile  Lys His Leu Lys Ser  Glu Leu Trp 
    4130                 4135                 4140             


Ile Tyr  Leu Gln Asp Ala Asp  Gln Gln Leu Gln Asn  Met Lys Arg 
    4145                 4150                 4155             


Arg His  Ser Glu Leu Glu Leu  Asn Ile Ala Gln Asn  Met Val Ser 
    4160                 4165                 4170             


Gln Val  Lys Asp Phe Val Lys  Lys Leu Gln Ser Lys  Gln Ala Ser 
    4175                 4180                 4185             


Val Asn  Thr Ile Ile Glu Lys  Val Asn Lys Leu Thr  Lys Lys Glu 
    4190                 4195                 4200             


Glu Ser  Pro Glu His Lys Glu  Ile Asn His Leu Asn  Asp Gln Trp 
    4205                 4210                 4215             


Leu Asp  Leu Cys Arg Gln Ser  Asn Asn Leu Cys Leu  Gln Arg Glu 
    4220                 4225                 4230             


Glu Asp  Leu Gln Arg Thr Arg  Asp Tyr His Asp Cys  Met Asn Val 
    4235                 4240                 4245             


Val Glu  Val Phe Leu Glu Lys  Phe Thr Thr Glu Trp  Asp Asn Leu 
    4250                 4255                 4260             


Ala Arg  Ser Asp Ala Glu Ser  Thr Ala Val His Leu  Glu Ala Leu 
    4265                 4270                 4275             


Lys Lys  Leu Ala Leu Ala Leu  Gln Glu Arg Lys Tyr  Ala Ile Glu 
    4280                 4285                 4290             


Asp Leu  Lys Asp Gln Lys Gln  Lys Met Ile Glu His  Leu Asn Leu 
    4295                 4300                 4305             


Asp Asp  Lys Glu Leu Val Lys  Glu Gln Thr Ser His  Leu Glu Gln 
    4310                 4315                 4320             


Arg Trp  Phe Gln Leu Glu Asp  Leu Ile Lys Arg Lys  Ile Gln Val 
    4325                 4330                 4335             


Ser Val  Thr Asn Leu Glu Glu  Leu Asn Val Val Gln  Ser Arg Phe 
    4340                 4345                 4350             


Gln Glu  Leu Met Glu Trp Ala  Glu Glu Gln Gln Pro  Asn Ile Ala 
    4355                 4360                 4365             


Glu Ala  Leu Lys Gln Ser Pro  Pro Pro Asp Met Ala  Gln Asn Leu 
    4370                 4375                 4380             


Leu Met  Asp His Leu Ala Ile  Cys Ser Glu Leu Glu  Ala Lys Gln 
    4385                 4390                 4395             


Met Leu  Leu Lys Ser Leu Ile  Lys Asp Ala Asp Arg  Val Met Ala 
    4400                 4405                 4410             


Asp Leu  Gly Leu Asn Glu Arg  Gln Val Ile Gln Lys  Ala Leu Ser 
    4415                 4420                 4425             


Asp Ala  Gln Ser His Val Asn  Cys Leu Ser Asp Leu  Val Gly Gln 
    4430                 4435                 4440             


Arg Arg  Lys Tyr Leu Asn Lys  Ala Leu Ser Glu Lys  Thr Gln Phe 
    4445                 4450                 4455             


Leu Met  Ala Val Phe Gln Ala  Thr Ser Gln Ile Gln  Gln His Glu 
    4460                 4465                 4470             


Arg Lys  Ile Met Phe Arg Glu  His Ile Cys Leu Leu  Pro Asp Asp 
    4475                 4480                 4485             


Val Ser  Lys Gln Val Lys Thr  Cys Lys Ser Ala Gln  Ala Ser Leu 
    4490                 4495                 4500             


Lys Thr  Tyr Gln Asn Glu Val  Thr Gly Leu Trp Ala  Gln Gly Arg 
    4505                 4510                 4515             


Glu Leu  Met Lys Glu Val Thr  Glu Gln Glu Lys Ser  Glu Val Leu 
    4520                 4525                 4530             


Gly Lys  Leu Gln Glu Leu Gln  Ser Val Tyr Asp Ser  Val Leu Gln 
    4535                 4540                 4545             


Lys Cys  Ser His Arg Leu Gln  Glu Leu Glu Lys Asn  Leu Val Ser 
    4550                 4555                 4560             


Arg Lys  His Phe Lys Glu Asp  Phe Asp Lys Ala Cys  His Trp Leu 
    4565                 4570                 4575             


Lys Gln  Ala Asp Ile Val Thr  Phe Pro Glu Ile Asn  Leu Met Asn 
    4580                 4585                 4590             


Glu Ser  Ser Glu Leu His Thr  Gln Leu Ala Lys Tyr  Gln Asn Ile 
    4595                 4600                 4605             


Leu Glu  Gln Ser Pro Glu Tyr  Glu Asn Leu Leu Leu  Thr Leu Gln 
    4610                 4615                 4620             


Arg Thr  Gly Gln Thr Ile Leu  Pro Ser Leu Asn Glu  Val Asp His 
    4625                 4630                 4635             


Ser Tyr  Leu Ser Glu Lys Leu  Asn Ala Leu Pro Arg  Gln Phe Asn 
    4640                 4645                 4650             


Val Ile  Val Ala Leu Ala Lys  Asp Lys Phe Tyr Lys  Val Gln Glu 
    4655                 4660                 4665             


Ala Ile  Leu Ala Arg Lys Glu  Tyr Ala Ser Leu Ile  Glu Leu Thr 
    4670                 4675                 4680             


Thr Gln  Ser Leu Ser Glu Leu  Glu Ala Gln Phe Leu  Arg Met Ser 
    4685                 4690                 4695             


Lys Val  Pro Thr Asp Leu Ala  Val Glu Glu Ala Leu  Ser Leu Gln 
    4700                 4705                 4710             


Asp Gly  Cys Arg Ala Ile Leu  Asp Glu Val Ala Gly  Leu Gly Glu 
    4715                 4720                 4725             


Ala Val  Asp Glu Leu Asn Gln  Lys Lys Glu Gly Phe  Arg Ser Thr 
    4730                 4735                 4740             


Gly Gln  Pro Trp Gln Pro Asp  Lys Met Leu His Leu  Val Thr Leu 
    4745                 4750                 4755             


Tyr His  Arg Leu Lys Arg Gln  Thr Glu Gln Arg Val  Ser Leu Leu 
    4760                 4765                 4770             


Glu Asp  Thr Thr Ser Ala Tyr  Gln Glu His Glu Lys  Met Cys Gln 
    4775                 4780                 4785             


Gln Leu  Glu Arg Gln Leu Lys  Ser Val Lys Glu Glu  Gln Ser Lys 
    4790                 4795                 4800             


Val Asn  Glu Glu Thr Leu Pro  Ala Glu Glu Lys Leu  Lys Met Tyr 
    4805                 4810                 4815             


His Ser  Leu Ala Gly Ser Leu  Gln Asp Ser Gly Ile  Val Leu Lys 
    4820                 4825                 4830             


Arg Val  Thr Ile His Leu Glu  Asp Leu Ala Pro His  Leu Asp Pro 
    4835                 4840                 4845             


Leu Ala  Tyr Glu Lys Ala Arg  His Gln Ile Gln Ser  Trp Gln Gly 
    4850                 4855                 4860             


Glu Leu  Lys Leu Leu Thr Ser  Ala Ile Gly Glu Thr  Val Thr Glu 
    4865                 4870                 4875             


Cys Glu  Ser Arg Met Val Gln  Ser Ile Asp Phe Gln  Thr Glu Met 
    4880                 4885                 4890             


Ser Arg  Ser Leu Asp Trp Leu  Arg Arg Val Lys Ala  Glu Leu Ser 
    4895                 4900                 4905             


Gly Pro  Val Tyr Leu Asp Leu  Asn Leu Gln Asp Ile  Gln Glu Glu 
    4910                 4915                 4920             


Ile Arg  Lys Ile Gln Ile His  Gln Glu Glu Val Gln  Ser Ser Leu 
    4925                 4930                 4935             


Arg Ile  Met Asn Ala Leu Ser  His Lys Glu Lys Glu  Lys Phe Thr 
    4940                 4945                 4950             


Lys Ala  Lys Glu Leu Ile Ser  Ala Asp Leu Glu His  Ser Leu Ala 
    4955                 4960                 4965             


Glu Leu  Ser Glu Leu Asp Gly  Asp Ile Gln Glu Ala  Leu Arg Thr 
    4970                 4975                 4980             


Arg Gln  Ala Thr Leu Thr Glu  Ile Tyr Ser Gln Cys  Gln Arg Tyr 
    4985                 4990                 4995             


Tyr Gln  Val Phe Gln Ala Ala  Asn Asp Trp Leu Glu  Asp Ala Gln 
    5000                 5005                 5010             


Glu Leu  Leu Gln Leu Ala Gly  Asn Gly Leu Asp Val  Glu Ser Ala 
    5015                 5020                 5025             


Glu Glu  Asn Leu Lys Ser His  Met Glu Phe Phe Ser  Thr Glu Asp 
    5030                 5035                 5040             


Gln Phe  His Ser Asn Leu Glu  Glu Leu His Ser Leu  Val Ala Thr 
    5045                 5050                 5055             


Leu Asp  Pro Leu Ile Lys Pro  Thr Gly Lys Glu Asp  Leu Glu Gln 
    5060                 5065                 5070             


Lys Val  Ala Ser Leu Glu Leu  Arg Ser Gln Arg Met  Ser Arg Asp 
    5075                 5080                 5085             


Ser Gly  Ala Gln Val Asp Leu  Leu Gln Arg Cys Thr  Ala Gln Trp 
    5090                 5095                 5100             


His Asp  Tyr Gln Lys Ala Arg  Glu Glu Val Ile Glu  Leu Met Asn 
    5105                 5110                 5115             


Asp Thr  Glu Lys Lys Leu Ser  Glu Phe Ser Leu Leu  Lys Thr Ser 
    5120                 5125                 5130             


Ser Ser  His Glu Ala Glu Glu  Lys Leu Ser Glu His  Lys Ala Leu 
    5135                 5140                 5145             


Val Ser  Val Val Asn Ser Phe  His Glu Lys Ile Val  Ala Leu Glu 
    5150                 5155                 5160             


Glu Lys  Ala Ser Gln Leu Glu  Lys Thr Gly Asn Asp  Ala Ser Lys 
    5165                 5170                 5175             


Ala Thr  Leu Ser Arg Ser Met  Thr Thr Val Trp Gln  Arg Trp Thr 
    5180                 5185                 5190             


Arg Leu  Arg Ala Val Ala Gln  Asp Gln Glu Lys Ile  Leu Glu Asp 
    5195                 5200                 5205             


Ala Val  Asp Glu Trp Thr Gly  Phe Asn Asn Lys Val  Lys Lys Ala 
    5210                 5215                 5220             


Thr Glu  Met Ile Asp Gln Leu  Gln Asp Lys Leu Pro  Gly Ser Ser 
    5225                 5230                 5235             


Ala Glu  Lys Ala Ser Lys Ala  Glu Leu Leu Thr Leu  Leu Glu Tyr 
    5240                 5245                 5250             


His Asp  Thr Phe Val Leu Glu  Leu Glu Gln Gln Gln  Ser Ala Leu 
    5255                 5260                 5265             


Gly Met  Leu Arg Gln Gln Thr  Leu Ser Met Leu Gln  Asp Gly Ala 
    5270                 5275                 5280             


Ala Pro  Thr Pro Gly Glu Glu  Pro Pro Leu Met Gln  Glu Ile Thr 
    5285                 5290                 5295             


Ala Met  Gln Asp Arg Cys Leu  Asn Met Gln Glu Lys  Val Lys Thr 
    5300                 5305                 5310             


Asn Gly  Lys Leu Val Lys Gln  Glu Leu Lys Asp Arg  Glu Met Val 
    5315                 5320                 5325             


Glu Thr  Gln Ile Asn Ser Val  Lys Cys Trp Val Gln  Glu Thr Lys 
    5330                 5335                 5340             


Glu Tyr  Leu Gly Asn Pro Thr  Ile Glu Ile Asp Ala  Gln Leu Glu 
    5345                 5350                 5355             


Glu Leu  Gln Ile Leu Leu Thr  Glu Ala Thr Asn His  Arg Gln Asn 
    5360                 5365                 5370             


Ile Glu  Lys Met Ala Glu Glu  Gln Lys Glu Lys Tyr  Leu Gly Leu 
    5375                 5380                 5385             


Tyr Thr  Ile Leu Pro Ser Glu  Leu Ser Leu Gln Leu  Ala Glu Val 
    5390                 5395                 5400             


Ala Leu  Asp Leu Lys Ile Arg  Asp Gln Ile Gln Asp  Lys Ile Lys 
    5405                 5410                 5415             


Glu Val  Glu Gln Ser Lys Ala  Thr Ser Gln Glu Leu  Ser Arg Gln 
    5420                 5425                 5430             


Ile Gln  Lys Leu Ala Lys Asp  Leu Thr Thr Ile Leu  Thr Lys Leu 
    5435                 5440                 5445             


Lys Ala  Lys Thr Asp Asn Val  Val Gln Ala Lys Thr  Asp Gln Lys 
    5450                 5455                 5460             


Val Leu  Gly Glu Glu Leu Asp  Gly Cys Asn Ser Lys  Leu Met Glu 
    5465                 5470                 5475             


Leu Asp  Ala Ala Val Gln Lys  Phe Leu Glu Gln Asn  Gly Gln Leu 
    5480                 5485                 5490             


Gly Lys  Pro Leu Ala Lys Lys  Ile Gly Lys Leu Thr  Glu Leu His 
    5495                 5500                 5505             


Gln Gln  Thr Ile Arg Gln Ala  Glu Asn Arg Leu Ser  Lys Leu Asn 
    5510                 5515                 5520             


Gln Ala  Ala Ser His Leu Glu  Glu Tyr Asn Glu Met  Leu Glu Leu 
    5525                 5530                 5535             


Ile Leu  Lys Trp Ile Glu Lys  Ala Lys Val Leu Ala  His Gly Thr 
    5540                 5545                 5550             


Ile Ala  Trp Asn Ser Ala Ser  Gln Leu Arg Glu Gln  Tyr Ile Leu 
    5555                 5560                 5565             


His Gln  Thr Leu Leu Glu Glu  Ser Lys Glu Ile Asp  Ser Glu Leu 
    5570                 5575                 5580             


Glu Ala  Met Thr Glu Lys Leu  Gln Tyr Leu Thr Ser  Val Tyr Cys 
    5585                 5590                 5595             


Thr Glu  Lys Met Ser Gln Gln  Val Ala Glu Leu Gly  Arg Glu Thr 
    5600                 5605                 5610             


Glu Glu  Leu Arg Gln Met Ile  Lys Ile Arg Leu Gln  Asn Leu Gln 
    5615                 5620                 5625             


Asp Ala  Ala Lys Asp Met Lys  Lys Phe Glu Ala Glu  Leu Lys Lys 
    5630                 5635                 5640             


Leu Gln  Ala Ala Leu Glu Gln  Ala Gln Ala Thr Leu  Thr Ser Pro 
    5645                 5650                 5655             


Glu Val  Gly Arg Leu Ser Leu  Lys Glu Gln Leu Ser  His Arg Gln 
    5660                 5665                 5670             


His Leu  Leu Ser Glu Met Glu  Ser Leu Lys Pro Lys  Val Gln Ala 
    5675                 5680                 5685             


Val Gln  Leu Cys Gln Ser Ala  Leu Arg Ile Pro Glu  Asp Val Val 
    5690                 5695                 5700             


Ala Ser  Leu Pro Leu Cys His  Ala Ala Leu Arg Leu  Gln Glu Glu 
    5705                 5710                 5715             


Ala Ser  Arg Leu Gln His Thr  Ala Ile Gln Gln Cys  Asn Ile Met 
    5720                 5725                 5730             


Gln Glu  Ala Val Val Gln Tyr  Glu Gln Tyr Glu Gln  Glu Met Lys 
    5735                 5740                 5745             


His Leu  Gln Gln Leu Ile Glu  Gly Ala His Arg Glu  Ile Glu Asp 
    5750                 5755                 5760             


Lys Pro  Val Ala Thr Ser Asn  Ile Gln Glu Leu Gln  Ala Gln Ile 
    5765                 5770                 5775             


Ser Arg  His Glu Glu Leu Ala  Gln Lys Ile Lys Gly  Tyr Gln Glu 
    5780                 5785                 5790             


Gln Ile  Ala Ser Leu Asn Ser  Lys Cys Lys Met Leu  Thr Met Lys 
    5795                 5800                 5805             


Ala Lys  His Ala Thr Met Leu  Leu Thr Val Thr Glu  Val Glu Gly 
    5810                 5815                 5820             


Leu Ala  Glu Gly Thr Glu Asp  Leu Asp Gly Glu Leu  Leu Pro Thr 
    5825                 5830                 5835             


Pro Ser  Ala His Pro Ser Val  Val Met Met Thr Ala  Gly Arg Cys 
    5840                 5845                 5850             


His Thr  Leu Leu Ser Pro Val  Thr Glu Glu Ser Gly  Glu Glu Gly 
    5855                 5860                 5865             


Thr Asn  Ser Glu Ile Ser Ser  Pro Pro Ala Cys Arg  Ser Pro Ser 
    5870                 5875                 5880             


Pro Val  Ala Asn Thr Asp Ala  Ser Val Asn Gln Asp  Ile Ala Tyr 
    5885                 5890                 5895             


Tyr Gln  Ala Leu Ser Ala Glu  Arg Leu Gln Thr Asp  Ala Ala Lys 
    5900                 5905                 5910             


Ile His  Pro Ser Thr Ser Ala  Ser Gln Glu Phe Tyr  Glu Pro Gly 
    5915                 5920                 5925             


Leu Glu  Pro Ser Ala Thr Ala  Lys Leu Gly Asp Leu  Gln Arg Ser 
    5930                 5935                 5940             


Trp Glu  Thr Leu Lys Asn Val  Ile Ser Glu Lys Gln  Arg Thr Leu 
    5945                 5950                 5955             


Tyr Glu  Ala Leu Glu Arg Gln  Gln Lys Tyr Gln Asp  Ser Leu Gln 
    5960                 5965                 5970             


Ser Ile  Ser Thr Lys Met Glu  Ala Ile Glu Leu Lys  Leu Ser Glu 
    5975                 5980                 5985             


Ser Pro  Glu Pro Gly Arg Ser  Pro Glu Ser Gln Met  Ala Glu His 
    5990                 5995                 6000             


Gln Ala  Leu Met Asp Glu Ile  Leu Met Leu Gln Asp  Glu Ile Asn 
    6005                 6010                 6015             


Glu Leu  Gln Ser Ser Leu Ala  Glu Glu Leu Val Ser  Glu Ser Cys 
    6020                 6025                 6030             


Glu Ala  Asp Pro Ala Glu Gln  Leu Ala Leu Gln Ser  Thr Leu Thr 
    6035                 6040                 6045             


Val Leu  Ala Glu Arg Met Ser  Thr Ile Arg Met Lys  Ala Ser Gly 
    6050                 6055                 6060             


Lys Arg  Gln Leu Leu Glu Glu  Lys Leu Asn Asp Gln  Leu Glu Glu 
    6065                 6070                 6075             


Gln Arg  Gln Glu Gln Ala Leu  Gln Arg Tyr Arg Cys  Glu Ala Asp 
    6080                 6085                 6090             


Glu Leu  Asp Ser Trp Leu Leu  Ser Thr Lys Ala Thr  Leu Asp Thr 
    6095                 6100                 6105             


Ala Leu  Ser Pro Pro Lys Glu  Pro Met Asp Met Glu  Ala Gln Leu 
    6110                 6115                 6120             


Met Asp  Cys Gln Asn Met Leu  Val Glu Ile Glu Gln  Lys Val Val 
    6125                 6130                 6135             


Ala Leu  Ser Glu Leu Ser Val  His Asn Glu Asn Leu  Leu Leu Glu 
    6140                 6145                 6150             


Gly Lys  Ala His Thr Lys Asp  Glu Ala Glu Gln Leu  Ala Gly Lys 
    6155                 6160                 6165             


Leu Arg  Arg Leu Lys Gly Ser  Leu Leu Glu Leu Gln  Arg Ala Leu 
    6170                 6175                 6180             


His Asp  Lys Gln Leu Asn Met  Gln Gly Thr Ala Gln  Glu Lys Glu 
    6185                 6190                 6195             


Glu Ser  Asp Val Asp Leu Thr  Ala Thr Gln Ser Pro  Gly Val Gln 
    6200                 6205                 6210             


Glu Trp  Leu Ala Gln Ala Arg  Thr Thr Trp Thr Gln  Gln Arg Gln 
    6215                 6220                 6225             


Ser Ser  Leu Gln Gln Gln Lys  Glu Leu Glu Gln Glu  Leu Ala Glu 
    6230                 6235                 6240             


Gln Lys  Ser Leu Leu Arg Ser  Val Ala Ser Arg Gly  Glu Glu Ile 
    6245                 6250                 6255             


Leu Ile  Gln His Ser Ala Ala  Glu Thr Ser Gly Asp  Ala Gly Glu 
    6260                 6265                 6270             


Lys Pro  Asp Val Leu Ser Gln  Glu Leu Gly Met Glu  Gly Glu Lys 
    6275                 6280                 6285             


Ser Ser  Ala Glu Asp Gln Met  Arg Met Lys Trp Glu  Ser Leu His 
    6290                 6295                 6300             


Gln Glu  Phe Ser Thr Lys Gln  Lys Leu Leu Gln Asn  Val Leu Glu 
    6305                 6310                 6315             


Gln Glu  Gln Glu Gln Val Leu  Tyr Ser Arg Pro Asn  Arg Leu Leu 
    6320                 6325                 6330             


Ser Gly  Val Pro Leu Tyr Lys  Gly Asp Val Pro Thr  Gln Asp Lys 
    6335                 6340                 6345             


Ser Ala  Val Thr Ser Leu Leu  Asp Gly Leu Asn Gln  Ala Phe Glu 
    6350                 6355                 6360             


Glu Val  Ser Ser Gln Ser Gly  Gly Ala Lys Arg Gln  Ser Ile His 
    6365                 6370                 6375             


Leu Glu  Gln Lys Leu Tyr Asp  Gly Val Ser Ala Thr  Ser Thr Trp 
    6380                 6385                 6390             


Leu Asp  Asp Val Glu Glu Arg  Leu Phe Val Ala Thr  Ala Leu Leu 
    6395                 6400                 6405             


Pro Glu  Glu Thr Glu Thr Cys  Leu Phe Asn Gln Glu  Ile Leu Ala 
    6410                 6415                 6420             


Lys Asp  Ile Lys Glu Met Ser  Glu Glu Met Asp Lys  Asn Lys Asn 
    6425                 6430                 6435             


Leu Phe  Ser Gln Ala Phe Pro  Glu Asn Gly Asp Asn  Arg Asp Val 
    6440                 6445                 6450             


Ile Glu  Asp Thr Leu Gly Cys  Leu Leu Gly Arg Leu  Ser Leu Leu 
    6455                 6460                 6465             


Asp Ser  Val Val Asn Gln Arg  Cys His Gln Met Lys  Glu Arg Leu 
    6470                 6475                 6480             


Gln Gln  Ile Leu Asn Phe Gln  Asn Asp Leu Lys Val  Leu Phe Thr 
    6485                 6490                 6495             


Ser Leu  Ala Asp Asn Lys Tyr  Ile Ile Leu Gln Lys  Leu Ala Asn 
    6500                 6505                 6510             


Val Phe  Glu Gln Pro Val Ala  Glu Gln Ile Glu Ala  Ile Gln Gln 
    6515                 6520                 6525             


Ala Glu  Asp Gly Leu Lys Glu  Phe Asp Ala Gly Ile  Ile Glu Leu 
    6530                 6535                 6540             


Lys Arg  Arg Gly Asp Lys Leu  Gln Val Glu Gln Pro  Ser Met Gln 
    6545                 6550                 6555             


Glu Leu  Ser Lys Leu Gln Asp  Met Tyr Asp Glu Leu  Met Met Ile 
    6560                 6565                 6570             


Ile Gly  Ser Arg Arg Ser Gly  Leu Asn Gln Asn Leu  Thr Leu Lys 
    6575                 6580                 6585             


Ser Gln  Tyr Glu Arg Ala Leu  Gln Asp Leu Ala Asp  Leu Leu Glu 
    6590                 6595                 6600             


Thr Gly  Gln Glu Lys Met Ala  Gly Asp Gln Lys Ile  Ile Val Ser 
    6605                 6610                 6615             


Ser Lys  Glu Glu Ile Gln Gln  Leu Leu Asp Lys His  Lys Glu Tyr 
    6620                 6625                 6630             


Phe Gln  Gly Leu Glu Ser His  Met Ile Leu Thr Glu  Thr Leu Phe 
    6635                 6640                 6645             


Arg Lys  Ile Ile Ser Phe Ala  Val Gln Lys Glu Thr  Gln Phe His 
    6650                 6655                 6660             


Thr Glu  Leu Met Ala Gln Ala  Ser Ala Val Leu Lys  Arg Ala His 
    6665                 6670                 6675             


Lys Arg  Gly Val Glu Leu Glu  Tyr Ile Leu Glu Thr  Trp Ser His 
    6680                 6685                 6690             


Leu Asp  Glu Asp Gln Gln Glu  Leu Ser Arg Gln Leu  Glu Val Val 
    6695                 6700                 6705             


Glu Ser  Ser Ile Pro Ser Val  Gly Leu Val Glu Glu  Asn Glu Asp 
    6710                 6715                 6720             


Arg Leu  Ile Asp Arg Ile Thr  Leu Tyr Gln His Leu  Lys Ser Ser 
    6725                 6730                 6735             


Leu Asn  Glu Tyr Gln Pro Lys  Leu Tyr Gln Val Leu  Asp Asp Gly 
    6740                 6745                 6750             


Lys Arg  Leu Leu Ile Ser Ile  Ser Cys Ser Asp Leu  Glu Ser Gln 
    6755                 6760                 6765             


Leu Asn  Gln Leu Gly Glu Cys  Trp Leu Ser Asn Thr  Asn Lys Met 
    6770                 6775                 6780             


Ser Lys  Glu Leu His Arg Leu  Glu Thr Ile Leu Lys  His Trp Thr 
    6785                 6790                 6795             


Arg Tyr  Gln Ser Glu Ser Ala  Asp Leu Ile His Trp  Leu Gln Ser 
    6800                 6805                 6810             


Ala Lys  Asp Arg Leu Glu Phe  Trp Thr Gln Gln Ser  Val Thr Val 
    6815                 6820                 6825             


Pro Gln  Glu Leu Glu Met Val  Arg Asp His Leu Asn  Ala Phe Leu 
    6830                 6835                 6840             


Glu Phe  Ser Lys Glu Val Asp  Ala Gln Ser Ser Leu  Lys Ser Ser 
    6845                 6850                 6855             


Val Leu  Ser Thr Gly Asn Gln  Leu Leu Arg Leu Lys  Lys Val Asp 
    6860                 6865                 6870             


Thr Ala  Thr Leu Arg Ser Glu  Leu Ser Arg Ile Asp  Ser Gln Trp 
    6875                 6880                 6885             


Thr Asp  Leu Leu Thr Asn Ile  Pro Ala Val Gln Glu  Lys Leu His 
    6890                 6895                 6900             


Gln Leu  Gln Met Asp Lys Leu  Pro Ser Arg His Ala  Ile Ser Glu 
    6905                 6910                 6915             


Val Met  Ser Trp Ile Ser Leu  Met Glu Asn Val Ile  Gln Lys Asp 
    6920                 6925                 6930             


Glu Asp  Asn Ile Lys Asn Ser  Ile Gly Tyr Lys Ala  Ile His Glu 
    6935                 6940                 6945             


Tyr Leu  Gln Lys Tyr Lys Gly  Phe Lys Ile Asp Ile  Asn Cys Lys 
    6950                 6955                 6960             


Gln Leu  Thr Val Asp Phe Val  Asn Gln Ser Val Leu  Gln Ile Ser 
    6965                 6970                 6975             


Ser Gln  Asp Val Glu Ser Lys  Arg Ser Asp Lys Thr  Asp Phe Ala 
    6980                 6985                 6990             


Glu Gln  Leu Gly Ala Met Asn  Lys Ser Trp Gln Ile  Leu Gln Gly 
    6995                 7000                 7005             


Leu Val  Thr Glu Lys Ile Gln  Leu Leu Glu Gly Leu  Leu Glu Ser 
    7010                 7015                 7020             


Trp Ser  Glu Tyr Glu Asn Asn  Val Gln Cys Leu Lys  Thr Trp Phe 
    7025                 7030                 7035             


Glu Thr  Gln Glu Lys Arg Leu  Lys Gln Gln His Arg  Ile Gly Asp 
    7040                 7045                 7050             


Gln Ala  Ser Val Gln Asn Ala  Leu Lys Asp Cys Gln  Asp Leu Glu 
    7055                 7060                 7065             


Asp Leu  Ile Lys Ala Lys Glu  Lys Glu Val Glu Lys  Ile Glu Gln 
    7070                 7075                 7080             


Asn Gly  Leu Ala Leu Ile Gln  Asn Lys Lys Glu Asp  Val Ser Ser 
    7085                 7090                 7095             


Ile Val  Met Ser Thr Leu Arg  Glu Leu Gly Gln Thr  Trp Ala Asn 
    7100                 7105                 7110             


Leu Asp  His Met Val Gly Gln  Leu Lys Ile Leu Leu  Lys Ser Val 
    7115                 7120                 7125             


Leu Asp  Gln Trp Ser Ser His  Lys Val Ala Phe Asp  Lys Ile Asn 
    7130                 7135                 7140             


Ser Tyr  Leu Met Glu Ala Arg  Tyr Ser Leu Ser Arg  Phe Arg Leu 
    7145                 7150                 7155             


Leu Thr  Gly Ser Leu Glu Ala  Val Gln Val Gln Val  Asp Asn Leu 
    7160                 7165                 7170             


Gln Asn  Leu Gln Asp Asp Leu  Glu Lys Gln Glu Arg  Ser Leu Gln 
    7175                 7180                 7185             


Lys Phe  Gly Ser Ile Thr Asn  Gln Leu Leu Lys Glu  Cys His Pro 
    7190                 7195                 7200             


Pro Val  Thr Glu Thr Leu Thr  Asn Thr Leu Lys Glu  Val Asn Met 
    7205                 7210                 7215             


Arg Trp  Asn Asn Leu Leu Glu  Glu Ile Ala Glu Gln  Leu Gln Ser 
    7220                 7225                 7230             


Ser Lys  Ala Leu Leu Gln Leu  Trp Gln Arg Tyr Lys  Asp Tyr Ser 
    7235                 7240                 7245             


Lys Gln  Cys Ala Ser Thr Val  Gln Gln Gln Glu Asp  Arg Thr Asn 
    7250                 7255                 7260             


Glu Leu  Leu Lys Ala Ala Thr  Asn Lys Asp Ile Ala  Asp Asp Glu 
    7265                 7270                 7275             


Val Ala  Thr Trp Ile Gln Asp  Cys Asn Asp Leu Leu  Lys Gly Leu 
    7280                 7285                 7290             


Gly Thr  Val Lys Asp Ser Leu  Phe Phe Leu His Glu  Leu Gly Glu 
    7295                 7300                 7305             


Gln Leu  Lys Gln Gln Val Asp  Ala Ser Ala Ala Ser  Ala Ile Gln 
    7310                 7315                 7320             


Ser Asp  Gln Leu Ser Leu Ser  Gln His Leu Cys Ala  Leu Glu Gln 
    7325                 7330                 7335             


Ala Leu  Cys Lys Gln Gln Thr  Ser Leu Gln Ala Gly  Val Leu Asp 
    7340                 7345                 7350             


Tyr Glu  Thr Phe Ala Lys Ser  Leu Glu Ala Leu Glu  Ala Trp Ile 
    7355                 7360                 7365             


Val Glu  Ala Glu Glu Ile Leu  Gln Gly Gln Asp Pro  Ser His Ser 
    7370                 7375                 7380             


Ser Asp  Leu Ser Thr Ile Gln  Glu Arg Met Glu Glu  Leu Lys Gly 
    7385                 7390                 7395             


Gln Met  Leu Lys Phe Ser Ser  Met Ala Pro Asp Leu  Asp Arg Leu 
    7400                 7405                 7410             


Asn Glu  Leu Gly Tyr Arg Leu  Pro Leu Asn Asp Lys  Glu Ile Lys 
    7415                 7420                 7425             


Arg Met  Gln Asn Leu Asn Arg  His Trp Ser Leu Ile  Ser Ser Gln 
    7430                 7435                 7440             


Thr Thr  Glu Arg Phe Ser Lys  Leu Gln Ser Phe Leu  Leu Gln His 
    7445                 7450                 7455             


Gln Thr  Phe Leu Glu Lys Cys  Glu Thr Trp Met Glu  Phe Leu Val 
    7460                 7465                 7470             


Gln Thr  Glu Gln Lys Leu Ala  Val Glu Ile Ser Gly  Asn Tyr Gln 
    7475                 7480                 7485             


His Leu  Leu Glu Gln Gln Arg  Ala His Glu Leu Phe  Gln Ala Glu 
    7490                 7495                 7500             


Met Phe  Ser Arg Gln Gln Ile  Leu His Ser Ile Ile  Ile Asp Gly 
    7505                 7510                 7515             


Gln Arg  Leu Leu Glu Gln Gly  Gln Val Asp Asp Arg  Asp Glu Phe 
    7520                 7525                 7530             


Asn Leu  Lys Leu Thr Leu Leu  Ser Asn Gln Trp Gln  Gly Val Ile 
    7535                 7540                 7545             


Arg Arg  Ala Gln Gln Arg Arg  Gly Ile Ile Asp Ser  Gln Ile Arg 
    7550                 7555                 7560             


Gln Trp  Gln Arg Tyr Arg Glu  Met Ala Glu Lys Leu  Arg Lys Trp 
    7565                 7570                 7575             


Leu Val  Glu Val Ser Tyr Leu  Pro Met Ser Gly Leu  Gly Ser Val 
    7580                 7585                 7590             


Pro Ile  Pro Leu Gln Gln Ala  Arg Thr Leu Phe Asp  Glu Val Gln 
    7595                 7600                 7605             


Phe Lys  Glu Lys Val Phe Leu  Arg Gln Gln Gly Ser  Tyr Ile Leu 
    7610                 7615                 7620             


Thr Val  Glu Ala Gly Lys Gln  Leu Leu Leu Ser Ala  Asp Ser Gly 
    7625                 7630                 7635             


Ala Glu  Ala Ala Leu Gln Ala  Glu Leu Ala Glu Ile  Gln Glu Lys 
    7640                 7645                 7650             


Trp Lys  Ser Ala Ser Met Arg  Leu Glu Glu Gln Lys  Lys Lys Leu 
    7655                 7660                 7665             


Ala Phe  Leu Leu Lys Asp Trp  Glu Lys Cys Glu Lys  Gly Ile Ala 
    7670                 7675                 7680             


Asp Ser  Leu Glu Lys Leu Arg  Thr Phe Lys Lys Lys  Leu Ser Gln 
    7685                 7690                 7695             


Ser Leu  Pro Asp His His Glu  Glu Leu His Ala Glu  Gln Met Arg 
    7700                 7705                 7710             


Cys Lys  Glu Leu Glu Asn Ala  Val Gly Ser Trp Thr  Asp Asp Leu 
    7715                 7720                 7725             


Thr Gln  Leu Ser Leu Leu Lys  Asp Thr Leu Ser Ala  Tyr Ile Ser 
    7730                 7735                 7740             


Ala Asp  Asp Ile Ser Ile Leu  Asn Glu Arg Val Glu  Leu Leu Gln 
    7745                 7750                 7755             


Arg Gln  Trp Glu Glu Leu Cys  His Gln Leu Ser Leu  Arg Arg Gln 
    7760                 7765                 7770             


Gln Ile  Gly Glu Arg Leu Asn  Glu Trp Ala Val Phe  Ser Glu Lys 
    7775                 7780                 7785             


Asn Lys  Glu Leu Cys Glu Trp  Leu Thr Gln Met Glu  Ser Lys Val 
    7790                 7795                 7800             


Ser Gln  Asn Gly Asp Ile Leu  Ile Glu Glu Met Ile  Glu Lys Leu 
    7805                 7810                 7815             


Lys Lys  Asp Tyr Gln Glu Glu  Ile Ala Ile Ala Gln  Glu Asn Lys 
    7820                 7825                 7830             


Ile Gln  Leu Gln Gln Met Gly  Glu Arg Leu Ala Lys  Ala Ser His 
    7835                 7840                 7845             


Glu Ser  Lys Ala Ser Glu Ile  Glu Tyr Lys Leu Gly  Lys Val Asn 
    7850                 7855                 7860             


Asp Arg  Trp Gln His Leu Leu  Asp Leu Ile Ala Ala  Arg Val Lys 
    7865                 7870                 7875             


Lys Leu  Lys Glu Thr Leu Val  Ala Val Gln Gln Leu  Asp Lys Asn 
    7880                 7885                 7890             


Met Ser  Ser Leu Arg Thr Trp  Leu Ala His Ile Glu  Ser Glu Leu 
    7895                 7900                 7905             


Ala Lys  Pro Ile Val Tyr Asp  Ser Cys Asn Ser Glu  Glu Ile Gln 
    7910                 7915                 7920             


Arg Lys  Leu Asn Glu Gln Gln  Glu Leu Gln Arg Asp  Ile Glu Lys 
    7925                 7930                 7935             


His Ser  Thr Gly Val Ala Ser  Val Leu Asn Leu Cys  Glu Val Leu 
    7940                 7945                 7950             


Leu His  Asp Cys Asp Ala Cys  Ala Thr Asp Ala Glu  Cys Asp Ser 
    7955                 7960                 7965             


Ile Gln  Gln Ala Thr Arg Asn  Leu Asp Arg Arg Trp  Arg Asn Ile 
    7970                 7975                 7980             


Cys Ala  Met Ser Met Glu Arg  Arg Leu Lys Ile Glu  Glu Thr Trp 
    7985                 7990                 7995             


Arg Leu  Trp Gln Lys Phe Leu  Asp Asp Tyr Ser Arg  Phe Glu Asp 
    8000                 8005                 8010             


Trp Leu  Lys Ser Ser Glu Arg  Thr Ala Ala Phe Pro  Ser Ser Ser 
    8015                 8020                 8025             


Gly Val  Ile Tyr Thr Val Ala  Lys Glu Glu Leu Lys  Lys Phe Glu 
    8030                 8035                 8040             


Ala Phe  Gln Arg Gln Val His  Glu Cys Leu Thr Gln  Leu Glu Leu 
    8045                 8050                 8055             


Ile Asn  Lys Gln Tyr Arg Arg  Leu Ala Arg Glu Asn  Arg Thr Asp 
    8060                 8065                 8070             


Ser Ala  Cys Ser Leu Lys Gln  Met Val His Glu Gly  Asn Gln Arg 
    8075                 8080                 8085             


Trp Asp  Asn Leu Gln Lys Arg  Val Thr Ser Ile Leu  Arg Arg Leu 
    8090                 8095                 8100             


Lys His  Phe Ile Gly Gln Arg  Glu Glu Phe Glu Thr  Ala Arg Asp 
    8105                 8110                 8115             


Ser Ile  Leu Val Trp Leu Thr  Glu Met Asp Leu Gln  Leu Thr Asn 
    8120                 8125                 8130             


Ile Glu  His Phe Ser Glu Cys  Asp Val Gln Ala Lys  Ile Lys Gln 
    8135                 8140                 8145             


Leu Lys  Ala Phe Gln Gln Glu  Ile Ser Leu Asn His  Asn Lys Ile 
    8150                 8155                 8160             


Glu Gln  Ile Ile Ala Gln Gly  Glu Gln Leu Ile Glu  Lys Ser Glu 
    8165                 8170                 8175             


Pro Leu  Asp Ala Ala Ile Ile  Glu Glu Glu Leu Asp  Glu Leu Arg 
    8180                 8185                 8190             


Arg Tyr  Cys Gln Glu Val Phe  Gly Arg Val Glu Arg  Tyr His Lys 
    8195                 8200                 8205             


Lys Leu  Ile Arg Leu Pro Leu  Pro Asp Asp Glu His  Asp Leu Ser 
    8210                 8215                 8220             


Asp Arg  Glu Leu Glu Leu Glu  Asp Ser Ala Ala Leu  Ser Asp Leu 
    8225                 8230                 8235             


His Trp  His Asp Arg Ser Ala  Asp Ser Leu Leu Ser  Pro Gln Pro 
    8240                 8245                 8250             


Ser Ser  Asn Leu Ser Leu Ser  Leu Ala Gln Pro Leu  Arg Ser Glu 
    8255                 8260                 8265             


Arg Ser  Gly Arg Asp Thr Pro  Ala Ser Val Asp Ser  Ile Pro Leu 
    8270                 8275                 8280             


Glu Trp  Asp His Asp Tyr Asp  Leu Ser Arg Asp Leu  Glu Ser Ala 
    8285                 8290                 8295             


Met Ser  Arg Ala Leu Pro Ser  Glu Asp Glu Glu Gly  Gln Asp Asp 
    8300                 8305                 8310             


Lys Asp  Phe Tyr Leu Arg Gly  Ala Val Gly Leu Ser  Gly Asp His 
    8315                 8320                 8325             


Ser Ala  Leu Glu Ser Gln Ile  Arg Gln Leu Gly Lys  Ala Leu Asp 
    8330                 8335                 8340             


Asp Ser  Arg Phe Gln Ile Gln  Gln Thr Glu Asn Ile  Ile Arg Ser 
    8345                 8350                 8355             


Lys Thr  Pro Thr Gly Pro Glu  Leu Asp Thr Ser Tyr  Lys Gly Tyr 
    8360                 8365                 8370             


Met Lys  Leu Leu Gly Glu Cys  Ser Ser Ser Ile Asp  Ser Val Lys 
    8375                 8380                 8385             


Arg Leu  Glu His Lys Leu Lys  Glu Glu Glu Glu Ser  Leu Pro Gly 
    8390                 8395                 8400             


Phe Val  Asn Leu His Ser Thr  Glu Thr Gln Thr Ala  Gly Val Ile 
    8405                 8410                 8415             


Asp Arg  Trp Glu Leu Leu Gln  Ala Gln Ala Leu Ser  Lys Glu Leu 
    8420                 8425                 8430             


Arg Met  Lys Gln Asn Leu Gln  Lys Trp Gln Gln Phe  Asn Ser Asp 
    8435                 8440                 8445             


Leu Asn  Ser Ile Trp Ala Trp  Leu Gly Asp Thr Glu  Glu Glu Leu 
    8450                 8455                 8460             


Glu Gln  Leu Gln Arg Leu Glu  Leu Ser Thr Asp Ile  Gln Thr Ile 
    8465                 8470                 8475             


Glu Leu  Gln Ile Lys Lys Leu  Lys Glu Leu Gln Lys  Ala Val Asp 
    8480                 8485                 8490             


His Arg  Lys Ala Ile Ile Leu  Ser Ile Asn Leu Cys  Ser Pro Glu 
    8495                 8500                 8505             


Phe Thr  Gln Ala Asp Ser Lys  Glu Ser Arg Asp Leu  Gln Asp Arg 
    8510                 8515                 8520             


Leu Ser  Gln Met Asn Gly Arg  Trp Asp Arg Val Cys  Ser Leu Leu 
    8525                 8530                 8535             


Glu Glu  Trp Arg Gly Leu Leu  Gln Asp Ala Leu Met  Gln Cys Gln 
    8540                 8545                 8550             


Gly Phe  His Glu Met Ser His  Gly Leu Leu Leu Met  Leu Glu Asn 
    8555                 8560                 8565             


Ile Asp  Arg Arg Lys Asn Glu  Ile Val Pro Ile Asp  Ser Asn Leu 
    8570                 8575                 8580             


Asp Ala  Glu Ile Leu Gln Asp  His His Lys Gln Leu  Met Gln Ile 
    8585                 8590                 8595             


Lys His  Glu Leu Leu Glu Ser  Gln Leu Arg Val Ala  Ser Leu Gln 
    8600                 8605                 8610             


Asp Met  Ser Cys Gln Leu Leu  Val Asn Ala Glu Gly  Thr Asp Cys 
    8615                 8620                 8625             


Leu Glu  Ala Lys Glu Lys Val  His Val Ile Gly Asn  Arg Leu Lys 
    8630                 8635                 8640             


Leu Leu  Leu Lys Glu Val Ser  Arg His Ile Lys Glu  Leu Glu Lys 
    8645                 8650                 8655             


Leu Leu  Asp Val Ser Ser Ser  Gln Gln Asp Leu Ser  Ser Trp Ser 
    8660                 8665                 8670             


Ser Ala  Asp Glu Leu Asp Thr  Ser Gly Ser Val Ser  Pro Thr Ser 
    8675                 8680                 8685             


Gly Arg  Ser Thr Pro Asn Arg  Gln Lys Thr Pro Arg  Gly Lys Cys 
    8690                 8695                 8700             


Ser Leu  Ser Gln Pro Gly Pro  Ser Val Ser Ser Pro  His Ser Arg 
    8705                 8710                 8715             


Ser Thr  Lys Gly Gly Ser Asp  Ser Ser Leu Ser Glu  Pro Gly Pro 
    8720                 8725                 8730             


Gly Arg  Ser Gly Arg Gly Phe  Leu Phe Arg Val Leu  Arg Ala Ala 
    8735                 8740                 8745             


Leu Pro  Leu Gln Leu Leu Leu  Leu Leu Leu Ile Gly  Leu Ala Cys 
    8750                 8755                 8760             


Leu Val  Pro Met Ser Glu Glu  Asp Tyr Ser Cys Ala  Leu Ser Asn 
    8765                 8770                 8775             


Asn Phe  Ala Arg Ser Phe His  Pro Met Leu Arg Tyr  Thr Asn Gly 
    8780                 8785                 8790             


Pro Pro  Pro Leu 
    8795         


<210>  103
<211>  6885
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Ala Ser Ser Pro Glu Leu Pro Thr Glu Asp Glu Gln Gly Ser Trp 
1               5                   10                  15      


Gly Ile Asp Asp Leu His Ile Ser Leu Gln Ala Glu Gln Glu Asp Thr 
            20                  25                  30          


Gln Lys Lys Ala Phe Thr Cys Trp Ile Asn Ser Gln Leu Ala Arg His 
        35                  40                  45              


Thr Ser Pro Ser Val Ile Ser Asp Leu Phe Thr Asp Ile Lys Lys Gly 
    50                  55                  60                  


His Val Leu Leu Asp Leu Leu Glu Val Leu Ser Gly Gln Gln Leu Pro 
65                  70                  75                  80  


Arg Asp Lys Gly Ser Asn Thr Phe Gln Cys Arg Ile Asn Ile Glu His 
                85                  90                  95      


Ala Leu Thr Phe Leu Arg Asn Arg Ser Ile Lys Leu Ile Asn Ile His 
            100                 105                 110         


Val Thr Asp Ile Ile Asp Gly Asn Pro Ser Ile Ile Leu Gly Leu Ile 
        115                 120                 125             


Trp Thr Ile Ile Leu His Phe His Ile Glu Lys Leu Ala Gln Thr Leu 
    130                 135                 140                 


Ser Cys Asn Tyr Asn Gln Pro Ser Leu Asp Asp Val Ser Val Val Asp 
145                 150                 155                 160 


Ser Ser Pro Ala Ser Ser Pro Pro Ala Lys Lys Cys Ser Lys Val Gln 
                165                 170                 175     


Ala Arg Trp Gln Met Ser Ala Arg Lys Ala Leu Leu Leu Trp Ala Gln 
            180                 185                 190         


Glu Gln Cys Ala Thr Tyr Glu Ser Val Asn Val Thr Asp Phe Lys Ser 
        195                 200                 205             


Ser Trp Arg Asn Gly Met Ala Phe Leu Ala Ile Ile His Ala Leu Arg 
    210                 215                 220                 


Pro Asp Leu Ile Asp Met Lys Ser Val Lys His Arg Ser Asn Lys Asp 
225                 230                 235                 240 


Asn Leu Arg Glu Ala Phe Arg Ile Ala Glu Gln Glu Leu Lys Ile Pro 
                245                 250                 255     


Arg Leu Leu Glu Pro Glu Asp Val Asp Val Val Asp Pro Asp Glu Lys 
            260                 265                 270         


Ser Ile Met Thr Tyr Val Ala Gln Phe Leu Gln Tyr Ser Lys Asp Ala 
        275                 280                 285             


Pro Gly Thr Gly Glu Glu Ala Gln Gly Lys Val Lys Asp Ala Met Gly 
    290                 295                 300                 


Trp Leu Thr Leu Gln Lys Glu Lys Leu Gln Lys Leu Leu Lys Asp Ser 
305                 310                 315                 320 


Glu Asn Asp Thr Tyr Phe Lys Lys Tyr Asn Ser Leu Leu Ser Phe Met 
                325                 330                 335     


Glu Ser Phe Asn Glu Glu Lys Lys Ser Phe Leu Asp Val Leu Ser Ile 
            340                 345                 350         


Lys Arg Asp Leu Asp Glu Leu Asp Lys Asp His Leu Gln Leu Arg Glu 
        355                 360                 365             


Ala Trp Asp Gly Leu Asp His Gln Ile Asn Ala Trp Lys Ile Lys Leu 
    370                 375                 380                 


Asn Tyr Ala Leu Pro Pro Pro Leu His Gln Thr Glu Ala Trp Leu Gln 
385                 390                 395                 400 


Glu Val Glu Glu Leu Met Asp Glu Asp Leu Ser Ala Ser Gln Asp His 
                405                 410                 415     


Ser Gln Ala Val Thr Leu Ile Gln Glu Lys Met Thr Leu Phe Lys Ser 
            420                 425                 430         


Leu Met Asp Arg Phe Glu His His Ser Asn Ile Leu Leu Thr Phe Glu 
        435                 440                 445             


Asn Lys Asp Glu Asn His Leu Pro Leu Val Pro Pro Asn Lys Leu Glu 
    450                 455                 460                 


Glu Met Lys Arg Arg Ile Asn Asn Ile Leu Glu Lys Lys Phe Ile Leu 
465                 470                 475                 480 


Leu Leu Glu Phe His Tyr Tyr Lys Cys Leu Val Leu Gly Leu Val Asp 
                485                 490                 495     


Glu Val Lys Ser Lys Leu Asp Ile Trp Asn Ile Lys Tyr Gly Ser Arg 
            500                 505                 510         


Glu Ser Val Glu Leu Leu Leu Glu Asp Trp His Lys Phe Ile Glu Glu 
        515                 520                 525             


Lys Glu Phe Leu Ala Arg Leu Asp Thr Ser Phe Gln Lys Cys Gly Glu 
    530                 535                 540                 


Ile Tyr Lys Asn Leu Ala Gly Glu Cys Gln Asn Ile Asn Lys Gln Tyr 
545                 550                 555                 560 


Met Met Val Lys Ser Asp Val Cys Met Tyr Arg Lys Asn Ile Tyr Asn 
                565                 570                 575     


Val Lys Ser Thr Leu Gln Lys Val Leu Ala Cys Trp Ala Thr Tyr Val 
            580                 585                 590         


Glu Asn Leu Arg Leu Leu Arg Ala Cys Phe Glu Glu Thr Lys Lys Glu 
        595                 600                 605             


Glu Ile Lys Glu Val Pro Phe Glu Thr Leu Ala Gln Trp Asn Leu Glu 
    610                 615                 620                 


His Ala Thr Leu Asn Glu Ala Gly Asn Phe Leu Val Glu Val Ser Asn 
625                 630                 635                 640 


Asp Val Val Gly Ser Ser Ile Ser Lys Glu Leu Arg Arg Leu Asn Lys 
                645                 650                 655     


Arg Trp Arg Lys Leu Val Ser Lys Thr Gln Leu Glu Met Asn Leu Pro 
            660                 665                 670         


Leu Met Ile Lys Lys Gln Asp Gln Pro Thr Phe Asp Asn Ser Gly Asn 
        675                 680                 685             


Ile Leu Ser Lys Glu Glu Lys Ala Thr Val Glu Phe Ser Thr Asp Met 
    690                 695                 700                 


Ser Val Glu Leu Pro Glu Asn Tyr Asn Gln Asn Ile Lys Ala Gly Glu 
705                 710                 715                 720 


Lys His Glu Lys Glu Asn Glu Glu Phe Thr Gly Gln Leu Lys Val Ala 
                725                 730                 735     


Lys Asp Val Glu Lys Leu Ile Gly Gln Val Glu Ile Trp Glu Ala Glu 
            740                 745                 750         


Ala Lys Ser Val Leu Asp Gln Asp Asp Val Asp Thr Ser Met Glu Glu 
        755                 760                 765             


Ser Leu Lys His Leu Ile Ala Lys Gly Ser Met Phe Asp Glu Leu Met 
    770                 775                 780                 


Ala Arg Ser Glu Asp Met Leu Gln Met Asp Ile Gln Asn Ile Ser Ser 
785                 790                 795                 800 


Gln Glu Ser Phe Gln His Val Leu Thr Thr Gly Leu Gln Ala Lys Ile 
                805                 810                 815     


Gln Glu Ala Lys Glu Lys Val Gln Ile Asn Val Val Lys Leu Ile Ala 
            820                 825                 830         


Ala Leu Lys Asn Leu Thr Asp Val Ser Pro Asp Leu Asp Ile Arg Leu 
        835                 840                 845             


Lys Met Glu Glu Ser Gln Lys Glu Leu Glu Ser Tyr Met Met Arg Ala 
    850                 855                 860                 


Gln Gln Leu Leu Gly Gln Arg Glu Ser Pro Gly Glu Leu Ile Ser Lys 
865                 870                 875                 880 


His Lys Glu Ala Leu Ile Ile Ser Asn Thr Lys Ser Leu Ala Lys Tyr 
                885                 890                 895     


Leu Lys Ala Val Glu Glu Leu Lys Asn Asn Val Thr Glu Asp Ile Lys 
            900                 905                 910         


Met Ser Leu Glu Glu Lys Ser Arg Asp Val Cys Ala Lys Trp Glu Ser 
        915                 920                 925             


Leu His His Glu Leu Ser Leu Tyr Val Gln Gln Leu Lys Ile Asp Ile 
    930                 935                 940                 


Glu Lys Gly Lys Leu Ser Asp Asn Ile Leu Lys Leu Glu Lys Gln Ile 
945                 950                 955                 960 


Asn Lys Glu Lys Lys Leu Ile Arg Arg Gly Arg Thr Lys Gly Leu Ile 
                965                 970                 975     


Lys Glu His Glu Ala Cys Phe Ser Glu Glu Gly Cys Leu Tyr Gln Leu 
            980                 985                 990         


Asn His His Met Glu Val Leu Arg  Glu Leu Cys Glu Glu  Leu Pro Ser 
        995                 1000                 1005             


Gln Lys  Ser Gln Gln Glu Val  Lys Arg Leu Leu Lys  Asp Tyr Glu 
    1010                 1015                 1020             


Gln Lys  Ile Glu Arg Leu Leu  Lys Cys Ala Ser Glu  Ile His Met 
    1025                 1030                 1035             


Thr Leu  Gln Pro Thr Ala Gly  Gly Thr Ser Lys Asn  Glu Gly Thr 
    1040                 1045                 1050             


Ile Thr  Thr Ser Glu Asn Arg  Gly Gly Asp Pro His  Ser Glu Ala 
    1055                 1060                 1065             


Pro Phe  Ala Lys Ser Asp Asn  Gln Pro Ser Thr Glu  Lys Ala Met 
    1070                 1075                 1080             


Glu Pro  Thr Met Lys Phe Ser  Leu Ala Ser Val Leu  Arg Pro Leu 
    1085                 1090                 1095             


Gln Glu  Glu Ser Ile Met Glu  Lys Asp Tyr Ser Ala  Ser Ile Asn 
    1100                 1105                 1110             


Ser Leu  Leu Glu Arg Tyr Asp  Thr Tyr Arg Asp Ile  Leu Glu His 
    1115                 1120                 1125             


His Leu  Gln Asn Asn Lys Phe  Arg Ile Thr Ser Asp  Phe Ser Ser 
    1130                 1135                 1140             


Glu Glu  Asp Arg Ser Ser Ser  Cys Leu Gln Ala Lys  Leu Thr Asp 
    1145                 1150                 1155             


Leu Gln  Val Ile Lys Asn Glu  Thr Asp Ala Arg Trp  Lys Glu Phe 
    1160                 1165                 1170             


Glu Ile  Ile Ser Leu Lys Leu  Glu Asn His Val Asn  Asp Ile Lys 
    1175                 1180                 1185             


Lys Pro  Phe Val Ile Lys Glu  Arg Asp Thr Leu Lys  Glu Arg Glu 
    1190                 1195                 1200             


Arg Glu  Leu Gln Met Thr Leu  Asn Thr Arg Met Glu  Ser Leu Glu 
    1205                 1210                 1215             


Thr Ala  Leu Arg Leu Val Leu  Pro Val Glu Lys Ala  Ser Leu Leu 
    1220                 1225                 1230             


Leu Cys  Gly Ser Asp Leu Pro  Leu His Lys Met Ala  Ile Gln Gly 
    1235                 1240                 1245             


Phe His  Leu Ile Asp Ala Asp  Arg Ile Tyr Gln His  Leu Arg Asn 
    1250                 1255                 1260             


Ile Gln  Asp Ser Ile Ala Lys  Gln Ile Glu Ile Cys  Asn Arg Leu 
    1265                 1270                 1275             


Glu Glu  Pro Gly Asn Phe Val  Leu Lys Glu Leu His  Pro Phe Asp 
    1280                 1285                 1290             


Leu His  Ala Met Gln Asn Ile  Ile Leu Lys Tyr Lys  Thr Gln Phe 
    1295                 1300                 1305             


Glu Gly  Met Asn His Arg Val  Gln Arg Ser Glu Asp  Thr Leu Lys 
    1310                 1315                 1320             


Ala Leu  Glu Asp Phe Leu Ala  Ser Leu Arg Thr Ala  Lys Leu Ser 
    1325                 1330                 1335             


Ala Glu  Pro Val Thr Asp Leu  Ser Ala Ser Asp Thr  Gln Val Ala 
    1340                 1345                 1350             


Gln Glu  Asn Thr Leu Thr Val  Lys Asn Lys Glu Gly  Glu Ile His 
    1355                 1360                 1365             


Leu Met  Lys Asp Lys Ala Lys  His Leu Asp Lys Cys  Leu Lys Met 
    1370                 1375                 1380             


Leu Asp  Met Ser Phe Lys Asp  Ala Glu Arg Gly Asp  Asp Thr Ser 
    1385                 1390                 1395             


Cys Glu  Asn Leu Leu Asp Ala  Phe Ser Ile Lys Leu  Ser Glu Thr 
    1400                 1405                 1410             


His Gly  Tyr Gly Val Gln Glu  Glu Phe Thr Glu Glu  Asn Lys Leu 
    1415                 1420                 1425             


Leu Glu  Ala Cys Ile Phe Lys  Asn Asn Glu Leu Leu  Lys Asn Ile 
    1430                 1435                 1440             


Gln Asp  Val Gln Ser Gln Ile  Ser Lys Ile Gly Leu  Lys Asp Pro 
    1445                 1450                 1455             


Thr Val  Pro Ala Val Lys His  Arg Lys Lys Ser Leu  Ile Arg Leu 
    1460                 1465                 1470             


Asp Lys  Val Leu Asp Glu Tyr  Glu Glu Glu Lys Arg  His Leu Gln 
    1475                 1480                 1485             


Glu Met  Ala Asn Ser Leu Pro  His Phe Lys Asp Gly  Arg Glu Lys 
    1490                 1495                 1500             


Thr Val  Asn Gln Gln Cys Gln  Asn Thr Val Val Leu  Trp Glu Asn 
    1505                 1510                 1515             


Thr Lys  Ala Leu Val Thr Glu  Cys Leu Glu Gln Cys  Gly Arg Val 
    1520                 1525                 1530             


Leu Glu  Leu Leu Lys Gln Tyr  Gln Asn Phe Lys Ser  Ile Leu Thr 
    1535                 1540                 1545             


Thr Leu  Ile Gln Lys Glu Glu  Ser Val Ile Ser Leu  Gln Ala Ser 
    1550                 1555                 1560             


Tyr Met  Gly Lys Glu Asn Leu  Lys Lys Arg Ile Ala  Glu Ile Glu 
    1565                 1570                 1575             


Ile Val  Lys Glu Glu Phe Asn  Glu His Leu Glu Val  Val Asp Lys 
    1580                 1585                 1590             


Ile Asn  Gln Val Cys Lys Asn  Leu Gln Phe Tyr Leu  Asn Lys Met 
    1595                 1600                 1605             


Lys Thr  Phe Glu Glu Pro Pro  Phe Glu Lys Glu Ala  Asn Ile Ile 
    1610                 1615                 1620             


Val Asp  Arg Trp Leu Asp Ile  Asn Glu Lys Thr Glu  Asp Tyr Tyr 
    1625                 1630                 1635             


Glu Asn  Leu Gly Arg Ala Leu  Ala Leu Trp Asp Lys  Leu Phe Asn 
    1640                 1645                 1650             


Leu Lys  Asn Val Ile Asp Glu  Trp Thr Glu Lys Ala  Leu Gln Lys 
    1655                 1660                 1665             


Met Glu  Leu His Gln Leu Thr  Glu Glu Asp Arg Glu  Arg Leu Lys 
    1670                 1675                 1680             


Glu Glu  Leu Gln Val His Glu  Gln Lys Thr Ser Glu  Phe Ser Arg 
    1685                 1690                 1695             


Arg Val  Ala Glu Ile Gln Phe  Leu Leu Gln Ser Ser  Glu Ile Pro 
    1700                 1705                 1710             


Leu Glu  Leu Gln Val Met Glu  Ser Ser Ile Leu Asn  Lys Met Glu 
    1715                 1720                 1725             


His Val  Gln Lys Cys Leu Thr  Gly Glu Ser Asn Cys  His Ala Leu 
    1730                 1735                 1740             


Ser Gly  Ser Thr Ala Glu Leu  Arg Glu Asp Leu Asp  Gln Ala Lys 
    1745                 1750                 1755             


Thr Gln  Ile Gly Met Thr Glu  Ser Leu Leu Lys Ala  Leu Ser Pro 
    1760                 1765                 1770             


Ser Asp  Ser Leu Glu Ile Phe  Thr Lys Leu Glu Glu  Ile Gln Gln 
    1775                 1780                 1785             


Gln Ile  Leu Gln Gln Lys His  Ser Met Ile Leu Leu  Glu Asn Gln 
    1790                 1795                 1800             


Ile Gly  Cys Leu Thr Pro Glu  Leu Ser Glu Leu Lys  Lys Gln Tyr 
    1805                 1810                 1815             


Glu Ser  Val Ser Asp Leu Phe  Asn Thr Lys Lys Ser  Val Leu Gln 
    1820                 1825                 1830             


Asp His  Phe Ser Lys Leu Leu  Asn Asp Gln Cys Lys  Asn Phe Asn 
    1835                 1840                 1845             


Asp Trp  Phe Ser Asn Ile Lys  Val Asn Leu Lys Glu  Cys Phe Glu 
    1850                 1855                 1860             


Ser Ser  Glu Thr Lys Lys Ser  Val Glu Gln Lys Leu  Gln Lys Leu 
    1865                 1870                 1875             


Ser Asp  Phe Leu Thr Leu Glu  Gly Arg Asn Ser Lys  Ile Lys Gln 
    1880                 1885                 1890             


Val Asp  Ser Val Leu Lys His  Val Lys Lys His Leu  Pro Lys Ala 
    1895                 1900                 1905             


His Val  Lys Glu Leu Ile Ser  Trp Leu Val Gly Gln  Glu Phe Glu 
    1910                 1915                 1920             


Leu Glu  Lys Met Glu Ser Ile  Cys Gln Ala Arg Ala  Lys Glu Leu 
    1925                 1930                 1935             


Glu Asp  Ser Leu Gln Gln Leu  Leu Arg Leu Gln Asp  Asp His Arg 
    1940                 1945                 1950             


Asn Leu  Arg Lys Trp Leu Thr  Asn Gln Glu Glu Lys  Trp Lys Gly 
    1955                 1960                 1965             


Met Glu  Glu Pro Gly Glu Lys  Thr Glu Leu Phe Cys  Gln Ala Leu 
    1970                 1975                 1980             


Ala Arg  Lys Arg Glu Gln Phe  Glu Ser Val Ala Gln  Leu Asn Asn 
    1985                 1990                 1995             


Ser Leu  Lys Glu Tyr Gly Phe  Thr Glu Glu Glu Glu  Ile Ile Met 
    2000                 2005                 2010             


Glu Ala  Thr Cys Leu Met Asp  Arg Tyr Gln Thr Leu  Leu Arg Gln 
    2015                 2020                 2025             


Leu Ser  Glu Ile Glu Glu Glu  Asp Lys Leu Leu Pro  Thr Glu Asp 
    2030                 2035                 2040             


Gln Ser  Phe Asn Asp Leu Ala  His Asp Val Ile His  Trp Ile Lys 
    2045                 2050                 2055             


Glu Ile  Lys Glu Ser Leu Met  Val Leu Asn Ser Ser  Glu Gly Lys 
    2060                 2065                 2070             


Met Pro  Leu Glu Glu Arg Ile  Gln Lys Ile Lys Glu  Ile Ile Leu 
    2075                 2080                 2085             


Leu Lys  Pro Glu Gly Asp Ala  Arg Ile Glu Thr Ile  Met Lys Gln 
    2090                 2095                 2100             


Ala Glu  Ser Ser Glu Ala Pro  Leu Val Gln Lys Thr  Leu Thr Asp 
    2105                 2110                 2115             


Ile Ser  Asn Gln Trp Asp Asn  Thr Leu His Leu Ala  Ser Thr Tyr 
    2120                 2125                 2130             


Leu Ser  His Gln Glu Lys Leu  Leu Leu Glu Gly Glu  Lys Tyr Leu 
    2135                 2140                 2145             


Gln Ser  Lys Glu Asp Leu Arg  Leu Met Leu Ile Glu  Leu Lys Lys 
    2150                 2155                 2160             


Lys Gln  Glu Ala Gly Phe Ala  Leu Gln His Gly Leu  Gln Glu Lys 
    2165                 2170                 2175             


Lys Ala  Gln Leu Lys Ile Tyr  Lys Lys Phe Leu Lys  Lys Ala Gln 
    2180                 2185                 2190             


Asp Leu  Thr Ser Leu Leu Lys  Glu Leu Lys Ser Gln  Gly Asn Tyr 
    2195                 2200                 2205             


Leu Leu  Glu Cys Thr Lys Asn  Pro Ser Phe Ser Glu  Glu Pro Trp 
    2210                 2215                 2220             


Leu Glu  Ile Lys His Leu His  Glu Ser Leu Leu Gln  Gln Leu Gln 
    2225                 2230                 2235             


Asp Ser  Val Gln Asn Leu Asp  Gly His Val Arg Glu  His Asp Ser 
    2240                 2245                 2250             


Tyr Gln  Val Cys Val Thr Asp  Leu Asn Thr Thr Leu  Asp Asn Phe 
    2255                 2260                 2265             


Ser Lys  Glu Phe Val Ser Phe  Ser Asp Lys Pro Val  Asp Gln Ile 
    2270                 2275                 2280             


Ala Val  Glu Glu Lys Leu Gln  Lys Leu Gln Glu Leu  Glu Asn Arg 
    2285                 2290                 2295             


Leu Ser  Leu Gln Asp Gly Thr  Leu Lys Lys Ile Leu  Ala Leu Ala 
    2300                 2305                 2310             


Lys Ser  Val Lys Gln Asn Thr  Ser Ser Val Gly Gln  Lys Ile Ile 
    2315                 2320                 2325             


Lys Asp  Asp Ile Lys Ser Leu  Gln Cys Lys Gln Lys  Asp Leu Glu 
    2330                 2335                 2340             


Asn Arg  Leu Ala Ser Ala Lys  Gln Glu Met Glu Cys  Cys Leu Asn 
    2345                 2350                 2355             


Ser Ile  Leu Lys Ser Lys Arg  Ser Thr Glu Lys Lys  Gly Lys Phe 
    2360                 2365                 2370             


Thr Leu  Pro Gly Arg Glu Lys  Gln Ala Thr Ser Asp  Val Gln Glu 
    2375                 2380                 2385             


Ser Thr  Gln Glu Ser Ala Ala  Val Glu Lys Leu Glu  Glu Asp Trp 
    2390                 2395                 2400             


Glu Ile  Asn Lys Asp Ser Ala  Val Glu Met Ala Met  Ser Lys Gln 
    2405                 2410                 2415             


Leu Ser  Leu Asn Ala Gln Glu  Ser Met Lys Asn Thr  Glu Asp Glu 
    2420                 2425                 2430             


Arg Lys  Val Asn Glu Leu Gln  Asn Gln Pro Leu Glu  Leu Asp Thr 
    2435                 2440                 2445             


Met Leu  Arg Asn Glu Gln Leu  Glu Glu Ile Glu Lys  Leu Tyr Thr 
    2450                 2455                 2460             


Gln Leu  Glu Ala Lys Lys Ala  Ala Ile Lys Pro Leu  Glu Gln Thr 
    2465                 2470                 2475             


Glu Cys  Leu Asn Lys Thr Glu  Thr Gly Ala Leu Val  Leu His Asn 
    2480                 2485                 2490             


Ile Gly  Tyr Ser Ala Gln His  Leu Asp Asn Leu Leu  Gln Ala Leu 
    2495                 2500                 2505             


Ile Thr  Leu Lys Lys Asn Lys  Glu Ser Gln Tyr Cys  Val Leu Arg 
    2510                 2515                 2520             


Asp Phe  Gln Glu Tyr Leu Ala  Ala Val Glu Ser Ser  Met Lys Ala 
    2525                 2530                 2535             


Leu Leu  Thr Asp Lys Glu Ser  Leu Lys Val Gly Pro  Leu Asp Ser 
    2540                 2545                 2550             


Val Thr  Tyr Leu Asp Lys Ile  Lys Lys Phe Ile Ala  Ser Ile Glu 
    2555                 2560                 2565             


Lys Glu  Lys Asp Ser Leu Gly  Asn Leu Lys Ile Lys  Trp Glu Asn 
    2570                 2575                 2580             


Leu Ser  Asn His Val Thr Asp  Met Asp Lys Lys Leu  Leu Glu Ser 
    2585                 2590                 2595             


Gln Ile  Lys Gln Leu Glu His  Gly Trp Glu Gln Val  Glu Gln Gln 
    2600                 2605                 2610             


Ile Gln  Lys Lys Tyr Ser Gln  Gln Val Val Glu Tyr  Asp Glu Phe 
    2615                 2620                 2625             


Thr Thr  Leu Met Asn Lys Val  Gln Asp Thr Glu Ile  Ser Leu Gln 
    2630                 2635                 2640             


Gln Gln  Gln Gln His Leu Gln  Leu Arg Leu Lys Ser  Pro Glu Glu 
    2645                 2650                 2655             


Arg Ala  Gly Asn Gln Ser Met  Ile Ala Leu Thr Thr  Asp Leu Gln 
    2660                 2665                 2670             


Ala Thr  Lys His Gly Phe Ser  Val Leu Lys Gly Gln  Ala Glu Leu 
    2675                 2680                 2685             


Gln Met  Lys Arg Ile Trp Gly  Glu Lys Glu Lys Lys  Asn Leu Glu 
    2690                 2695                 2700             


Asp Gly  Ile Asn Asn Leu Lys  Lys Gln Trp Glu Thr  Leu Glu Pro 
    2705                 2710                 2715             


Leu His  Leu Glu Ala Glu Asn  Gln Ile Lys Lys Cys  Asp Ile Arg 
    2720                 2725                 2730             


Asn Lys  Met Lys Glu Thr Ile  Leu Trp Ala Lys Asn  Leu Leu Gly 
    2735                 2740                 2745             


Glu Leu  Asn Pro Ser Ile Pro  Leu Leu Pro Asp Asp  Ile Leu Ser 
    2750                 2755                 2760             


Gln Ile  Arg Lys Cys Lys Val  Thr His Asp Gly Ile  Leu Ala Arg 
    2765                 2770                 2775             


Gln Gln  Ser Val Glu Ser Leu  Ala Glu Glu Val Lys  Asp Lys Val 
    2780                 2785                 2790             


Pro Ser  Leu Thr Thr Tyr Glu  Gly Ser Asp Leu Asn  Asn Thr Leu 
    2795                 2800                 2805             


Glu Asp  Leu Arg Asn Gln Tyr  Gln Met Leu Val Leu  Lys Ser Thr 
    2810                 2815                 2820             


Gln Arg  Ser Gln Gln Leu Glu  Phe Lys Leu Glu Glu  Arg Ser Asn 
    2825                 2830                 2835             


Phe Phe  Ala Ile Ile Arg Lys  Phe Gln Leu Met Val  Gln Glu Ser 
    2840                 2845                 2850             


Glu Thr  Leu Ile Ile Pro Arg  Val Glu Thr Ala Ala  Thr Glu Ala 
    2855                 2860                 2865             


Glu Leu  Lys His His His Val  Thr Leu Glu Ala Ser  Gln Lys Glu 
    2870                 2875                 2880             


Leu Gln  Glu Ile Asp Ser Gly  Ile Ser Thr His Leu  Gln Glu Leu 
    2885                 2890                 2895             


Thr Asn  Ile Tyr Glu Glu Leu  Asn Val Phe Glu Arg  Leu Phe Leu 
    2900                 2905                 2910             


Glu Asp  Gln Leu Lys Asn Leu  Lys Ile Arg Thr Asn  Arg Ile Gln 
    2915                 2920                 2925             


Arg Phe  Ile Gln Asn Thr Cys  Asn Glu Val Glu His  Lys Ile Lys 
    2930                 2935                 2940             


Phe Cys  Arg Gln Phe His Glu  Lys Thr Ser Ala Leu  Gln Glu Glu 
    2945                 2950                 2955             


Ala Asp  Ser Ile Gln Arg Asn  Glu Leu Leu Leu Asn  Gln Glu Val 
    2960                 2965                 2970             


Asn Lys  Gly Val Lys Glu Glu  Ile Tyr Asn Leu Lys  Asp Arg Leu 
    2975                 2980                 2985             


Thr Ala  Ile Lys Cys Cys Ile  Leu Gln Val Leu Lys  Leu Lys Lys 
    2990                 2995                 3000             


Val Phe  Asp Tyr Ile Gly Leu  Asn Trp Asp Phe Ser  Gln Leu Asp 
    3005                 3010                 3015             


Gln Leu  Gln Thr Gln Val Phe  Glu Lys Glu Lys Glu  Leu Glu Glu 
    3020                 3025                 3030             


Lys Ile  Lys Gln Leu Asp Thr  Phe Glu Glu Glu His  Gly Lys Tyr 
    3035                 3040                 3045             


Gln Ala  Leu Leu Ser Lys Met  Arg Ala Ile Asp Leu  Gln Ile Lys 
    3050                 3055                 3060             


Lys Met  Thr Glu Val Val Leu  Lys Ala Pro Asp Ser  Ser Pro Glu 
    3065                 3070                 3075             


Ser Arg  Arg Leu Asn Ala Gln  Ile Leu Ser Gln Arg  Ile Glu Lys 
    3080                 3085                 3090             


Ala Lys  Cys Leu Cys Asp Glu  Ile Ile Lys Lys Leu  Asn Glu Asn 
    3095                 3100                 3105             


Lys Thr  Phe Asp Asp Ser Phe  Lys Glu Lys Glu Ile  Leu Gln Ile 
    3110                 3115                 3120             


Lys Leu  Asn Ala Glu Glu Asn  Asp Lys Leu Tyr Lys  Val Leu Gln 
    3125                 3130                 3135             


Asn Met  Val Leu Glu Leu Ser  Pro Lys Glu Leu Asp  Glu Lys Asn 
    3140                 3145                 3150             


Cys Gln  Asp Lys Leu Glu Thr  Ser Leu His Val Leu  Asn Gln Ile 
    3155                 3160                 3165             


Lys Ser  Gln Leu Gln Gln Pro  Leu Leu Ile Asn Leu  Glu Ile Lys 
    3170                 3175                 3180             


His Ile  Gln Asn Glu Lys Asp  Asn Cys Glu Ala Phe  Gln Glu Gln 
    3185                 3190                 3195             


Val Trp  Ala Glu Met Cys Ser  Ile Lys Ala Val Thr  Ala Ile Glu 
    3200                 3205                 3210             


Lys Gln  Arg Glu Glu Asn Ser  Ser Glu Ala Ser Asp  Val Glu Thr 
    3215                 3220                 3225             


Lys Leu  Arg Glu Phe Glu Asp  Leu Gln Met Gln Leu  Asn Thr Ser 
    3230                 3235                 3240             


Ile Asp  Leu Arg Thr Asn Val  Leu Asn Asp Ala Tyr  Glu Asn Leu 
    3245                 3250                 3255             


Thr Arg  Tyr Lys Glu Ala Val  Thr Arg Ala Val Glu  Ser Ile Thr 
    3260                 3265                 3270             


Ser Leu  Glu Ala Ile Ile Ile  Pro Tyr Arg Val Asp  Val Gly Asn 
    3275                 3280                 3285             


Pro Glu  Glu Ser Leu Glu Met  Pro Leu Arg Lys Gln  Glu Glu Leu 
    3290                 3295                 3300             


Glu Ser  Thr Val Ala His Ile  Gln Asp Leu Thr Glu  Lys Leu Gly 
    3305                 3310                 3315             


Met Ile  Ser Ser Pro Glu Ala  Lys Leu Gln Leu Gln  Tyr Thr Leu 
    3320                 3325                 3330             


Gln Glu  Leu Val Ser Lys Asn  Ser Ala Met Lys Glu  Ala Phe Lys 
    3335                 3340                 3345             


Ala Gln  Glu Thr Glu Ala Glu  Arg Tyr Leu Glu Asn  Tyr Lys Cys 
    3350                 3355                 3360             


Tyr Arg  Lys Met Glu Glu Asp  Ile Tyr Thr Asn Leu  Ser Lys Met 
    3365                 3370                 3375             


Glu Thr  Val Leu Gly Gln Ser  Met Ser Ser Leu Pro  Leu Ser Tyr 
    3380                 3385                 3390             


Arg Glu  Ala Leu Glu Arg Leu  Glu Gln Ser Lys Ala  Leu Val Ser 
    3395                 3400                 3405             


Asn Leu  Ile Ser Thr Lys Glu  Glu Leu Met Lys Leu  Arg Gln Ile 
    3410                 3415                 3420             


Leu Arg  Leu Leu Arg Leu Arg  Cys Thr Glu Asn Asp  Gly Ile Cys 
    3425                 3430                 3435             


Leu Leu  Lys Ile Val Ser Ala  Leu Trp Glu Lys Trp  Leu Ser Leu 
    3440                 3445                 3450             


Leu Glu  Ala Ala Lys Glu Trp  Glu Met Trp Cys Glu  Glu Leu Lys 
    3455                 3460                 3465             


Gln Glu  Trp Lys Phe Val Ser  Glu Glu Ile Glu Arg  Glu Ala Ile 
    3470                 3475                 3480             


Ile Leu  Asp Asn Leu Gln Glu  Glu Leu Pro Glu Ile  Ser Lys Thr 
    3485                 3490                 3495             


Lys Glu  Ala Ala Thr Thr Glu  Glu Leu Ser Glu Leu  Leu Asp Cys 
    3500                 3505                 3510             


Leu Cys  Gln Tyr Gly Glu Asn  Val Glu Lys Gln Gln  Leu Leu Leu 
    3515                 3520                 3525             


Thr Leu  Leu Leu Gln Arg Ile  Arg Ser Ile Gln Asn  Val Pro Glu 
    3530                 3535                 3540             


Ser Ser  Gly Ala Val Glu Thr  Val Pro Ala Phe Gln  Glu Ile Thr 
    3545                 3550                 3555             


Ser Met  Lys Glu Arg Cys Asn  Lys Leu Leu Gln Lys  Val Gln Lys 
    3560                 3565                 3570             


Asn Lys  Glu Leu Val Gln Thr  Glu Ile Gln Glu Arg  His Ser Phe 
    3575                 3580                 3585             


Thr Lys  Glu Ile Ile Ala Leu  Lys Asn Phe Phe Gln  Gln Thr Thr 
    3590                 3595                 3600             


Thr Ser  Phe Gln Asn Met Ala  Phe Gln Asp His Pro  Glu Lys Ser 
    3605                 3610                 3615             


Glu Gln  Phe Glu Glu Leu Gln  Ser Ile Leu Lys Lys  Gly Lys Leu 
    3620                 3625                 3630             


Thr Phe  Glu Asn Ile Met Glu  Lys Leu Arg Ile Lys  Tyr Ser Glu 
    3635                 3640                 3645             


Met Tyr  Thr Ile Val Pro Ala  Glu Ile Glu Ser Gln  Val Glu Glu 
    3650                 3655                 3660             


Cys Arg  Lys Ala Leu Glu Asp  Ile Asp Glu Lys Ile  Ser Asn Glu 
    3665                 3670                 3675             


Val Leu  Lys Ser Ser Pro Ser  Tyr Ala Met Arg Arg  Lys Ile Glu 
    3680                 3685                 3690             


Glu Ile  Asn Asn Gly Leu His  Asn Val Glu Lys Met  Leu Gln Gln 
    3695                 3700                 3705             


Lys Ser  Lys Asn Ile Glu Lys  Ala Gln Glu Ile Gln  Lys Lys Met 
    3710                 3715                 3720             


Trp Asp  Glu Leu Asp Leu Trp  His Ser Lys Leu Asn  Glu Leu Asp 
    3725                 3730                 3735             


Ser Glu  Val Gln Asp Ile Val  Glu Gln Asp Pro Gly  Gln Ala Gln 
    3740                 3745                 3750             


Glu Trp  Met Asp Asn Leu Met  Ile Pro Phe Gln Gln  Tyr Gln Gln 
    3755                 3760                 3765             


Val Ser  Gln Arg Ala Glu Cys  Arg Thr Ser Gln Leu  Asn Lys Ala 
    3770                 3775                 3780             


Thr Val  Lys Met Glu Glu Tyr  Ser Asp Leu Leu Lys  Ser Thr Glu 
    3785                 3790                 3795             


Ala Trp  Ile Glu Asn Thr Ser  His Leu Leu Ala Asn  Pro Ala Asp 
    3800                 3805                 3810             


Tyr Asp  Ser Leu Arg Thr Leu  Ser His His Ala Ser  Thr Val Gln 
    3815                 3820                 3825             


Met Ala  Leu Glu Asp Ser Glu  Gln Lys His Asn Leu  Leu His Ser 
    3830                 3835                 3840             


Ile Phe  Met Asp Leu Glu Asp  Leu Ser Ile Ile Phe  Glu Thr Asp 
    3845                 3850                 3855             


Glu Leu  Thr Gln Ser Ile Gln  Glu Leu Ser Asn Gln  Val Thr Ala 
    3860                 3865                 3870             


Leu Gln  Gln Lys Ile Met Glu  Ser Leu Pro Gln Ile  Gln Arg Met 
    3875                 3880                 3885             


Ala Asp  Asp Val Val Ala Ile  Glu Ser Glu Val Lys  Ser Met Glu 
    3890                 3895                 3900             


Lys Arg  Val Ser Lys Ile Lys  Thr Ile Leu Leu Ser  Lys Glu Ile 
    3905                 3910                 3915             


Phe Asp  Phe Ser Pro Glu Glu  His Leu Lys His Gly  Glu Val Ile 
    3920                 3925                 3930             


Leu Glu  Asn Ile Arg Pro Met  Lys Lys Thr Ile Ala  Glu Ile Val 
    3935                 3940                 3945             


Ser Tyr  Gln Val Glu Leu Arg  Leu Pro Gln Thr Gly  Met Lys Pro 
    3950                 3955                 3960             


Leu Pro  Val Phe Gln Arg Thr  Asn Gln Leu Leu Gln  Asp Ile Lys 
    3965                 3970                 3975             


Leu Leu  Glu Asn Val Thr Gln  Glu Gln Asn Glu Leu  Leu Lys Val 
    3980                 3985                 3990             


Val Ile  Lys Gln Thr Asn Glu  Trp Asp Glu Glu Ile  Glu Asn Leu 
    3995                 4000                 4005             


Lys Gln  Ile Leu Asn Asn Tyr  Ser Ala Gln Phe Ser  Leu Glu His 
    4010                 4015                 4020             


Met Ser  Pro Asp Gln Ala Asp  Lys Leu Pro Gln Leu  Gln Gly Glu 
    4025                 4030                 4035             


Ile Glu  Arg Met Glu Lys Gln  Ile Leu Ser Leu Asn  Gln Arg Lys 
    4040                 4045                 4050             


Glu Asp  Leu Leu Val Asp Leu  Lys Ala Thr Val Leu  Asn Leu His 
    4055                 4060                 4065             


Gln His  Leu Lys Gln Glu Gln  Glu Gly Val Glu Arg  Asp Arg Leu 
    4070                 4075                 4080             


Pro Ala  Val Thr Ser Glu Glu  Gly Gly Val Ala Glu  Arg Asp Ala 
    4085                 4090                 4095             


Ser Glu  Arg Lys Leu Asn Arg  Arg Gly Ser Met Ser  Tyr Leu Ala 
    4100                 4105                 4110             


Ala Val  Glu Glu Glu Val Glu  Glu Ser Ser Val Lys  Ser Asp Asn 
    4115                 4120                 4125             


Gly Asp  Glu Lys Ala Glu Pro  Ser Pro Gln Ser Trp  Ser Ser Leu 
    4130                 4135                 4140             


Trp Lys  His Asp Lys Asp Met  Glu Glu Asp Arg Ala  Ser Ser Ser 
    4145                 4150                 4155             


Ser Gly  Thr Ile Val Gln Glu  Ala Tyr Gly Lys Ile  Ser Thr Ser 
    4160                 4165                 4170             


Asp Asn  Ser Met Ala Gln Ile  Leu Thr Pro Asp Ser  Leu Asn Thr 
    4175                 4180                 4185             


Glu Gln  Gly Pro Glu Cys Ser  Leu Arg Pro Asn Gln  Thr Glu Glu 
    4190                 4195                 4200             


Gly Thr  Thr Pro Pro Ile Glu  Ala Asp Thr Leu Asp  Ser Ser Asp 
    4205                 4210                 4215             


Ala Gln  Gly Gly Leu Glu Pro  Arg Val Glu Lys Thr  Arg Pro Glu 
    4220                 4225                 4230             


Pro Thr  Glu Val Leu His Ala  Cys Lys Thr Gln Val  Ala Glu Leu 
    4235                 4240                 4245             


Glu Leu  Trp Leu Gln Gln Ala  Asn Val Ala Val Glu  Pro Glu Thr 
    4250                 4255                 4260             


Leu Asn  Ala Asp Met Gln Gln  Val Leu Glu Gln Gln  Leu Val Gly 
    4265                 4270                 4275             


Cys Gln  Ala Met Leu Thr Glu  Ile Glu His Lys Val  Ala Phe Leu 
    4280                 4285                 4290             


Leu Glu  Thr Cys Lys Asp Gln  Gly Leu Gly Asp Asn  Gly Ala Thr 
    4295                 4300                 4305             


Gln His  Glu Ala Glu Ala Leu  Ser Leu Lys Leu Lys  Thr Val Lys 
    4310                 4315                 4320             


Cys Asn  Leu Glu Lys Val Gln  Met Met Leu Gln Glu  Lys His Ser 
    4325                 4330                 4335             


Glu Asp  Gln His Pro Thr Ile  Leu Lys Lys Ser Ser  Glu Pro Glu 
    4340                 4345                 4350             


His Gln  Glu Ala Leu Gln Pro  Val Asn Leu Ser Glu  Leu Glu Ser 
    4355                 4360                 4365             


Ile Val  Thr Glu Arg Pro Gln  Phe Ser Arg Gln Lys  Asp Phe Gln 
    4370                 4375                 4380             


Gln Gln  Gln Val Leu Glu Leu  Lys Pro Met Glu Gln  Lys Asp Phe 
    4385                 4390                 4395             


Ile Lys  Phe Ile Glu Phe Asn  Ala Lys Lys Met Trp  Pro Gln Tyr 
    4400                 4405                 4410             


Cys Gln  His Asp Asn Asp Thr  Thr Gln Glu Ser Ser  Ala Ser Asn 
    4415                 4420                 4425             


Gln Ala  Ser Ser Pro Glu Asn  Asp Val Pro Asp Ser  Ile Leu Ser 
    4430                 4435                 4440             


Pro Gln  Gly Gln Asn Gly Asp  Lys Trp Gln Tyr Leu  His His Glu 
    4445                 4450                 4455             


Leu Ser  Ser Lys Ile Lys Leu  Pro Leu Pro Gln Leu  Val Glu Pro 
    4460                 4465                 4470             


Gln Val  Ser Thr Asn Met Gly  Ile Leu Pro Ser Val  Thr Met Tyr 
    4475                 4480                 4485             


Asn Phe  Arg Tyr Pro Thr Thr  Glu Glu Leu Lys Thr  Tyr Thr Thr 
    4490                 4495                 4500             


Gln Leu  Glu Asp Leu Arg Gln  Glu Ala Ser Asn Leu  Gln Thr Gln 
    4505                 4510                 4515             


Glu Asn  Met Thr Glu Glu Ala  Tyr Ile Asn Leu Asp  Lys Lys Leu 
    4520                 4525                 4530             


Phe Glu  Leu Phe Leu Thr Leu  Ser Gln Cys Leu Ser  Ser Val Glu 
    4535                 4540                 4545             


Glu Met  Leu Glu Met Pro Arg  Leu Tyr Arg Glu Asp  Gly Ser Gly 
    4550                 4555                 4560             


Gln Gln  Val His Tyr Glu Thr  Leu Ala Leu Glu Leu  Lys Lys Leu 
    4565                 4570                 4575             


Tyr Leu  Ala Leu Ser Asp Lys  Lys Gly Asp Leu Leu  Lys Ala Met 
    4580                 4585                 4590             


Thr Trp  Pro Gly Glu Asn Thr  Asn Leu Leu Leu Glu  Cys Phe Asp 
    4595                 4600                 4605             


Asn Leu  Gln Val Cys Leu Glu  His Thr Gln Ala Ala  Ala Val Cys 
    4610                 4615                 4620             


Arg Ser  Lys Ser Leu Lys Ala  Gly Leu Asp Tyr Asn  Arg Ser Tyr 
    4625                 4630                 4635             


Gln Asn  Glu Ile Lys Arg Leu  Tyr His Gln Leu Ile  Lys Ser Lys 
    4640                 4645                 4650             


Thr Ser  Leu Gln Gln Ser Leu  Asn Glu Ile Ser Gly  Gln Ser Val 
    4655                 4660                 4665             


Ala Glu  Gln Leu Gln Lys Ala  Asp Ala Tyr Thr Val  Glu Leu Glu 
    4670                 4675                 4680             


Asn Ala  Glu Ser Arg Val Ala  Lys Leu Arg Asp Glu  Gly Glu Arg 
    4685                 4690                 4695             


Leu His  Leu Pro Tyr Ala Leu  Leu Gln Glu Val Tyr  Lys Leu Glu 
    4700                 4705                 4710             


Asp Val  Leu Asp Ser Met Trp  Gly Met Leu Arg Ala  Arg Tyr Thr 
    4715                 4720                 4725             


Glu Leu  Ser Ser Pro Phe Val  Thr Glu Ser Gln Gln  Asp Ala Leu 
    4730                 4735                 4740             


Leu Gln  Gly Met Val Glu Leu  Val Lys Ile Gly Lys  Glu Lys Leu 
    4745                 4750                 4755             


Ala His  Gly His Leu Lys Gln  Thr Lys Ser Lys Val  Ala Leu Gln 
    4760                 4765                 4770             


Ala Gln  Ile Glu Asn His Lys  Val Phe Phe Gln Lys  Leu Val Ala 
    4775                 4780                 4785             


Asp Met  Leu Leu Ile Gln Ala  Tyr Ser Ala Lys Ile  Leu Pro Ser 
    4790                 4795                 4800             


Leu Leu  Gln Asn Arg Glu Thr  Phe Trp Ala Glu Gln  Val Thr Glu 
    4805                 4810                 4815             


Val Lys  Ile Leu Glu Glu Lys  Ser Arg Gln Cys Gly  Met Lys Leu 
    4820                 4825                 4830             


Gln Ser  Leu Leu Gln Lys Trp  Glu Glu Phe Asp Glu  Asn Tyr Ala 
    4835                 4840                 4845             


Ser Leu  Glu Lys Asp Leu Glu  Ile Leu Ile Ser Thr  Leu Pro Ser 
    4850                 4855                 4860             


Val Ser  Leu Val Glu Glu Thr  Glu Glu Arg Leu Val  Glu Arg Ile 
    4865                 4870                 4875             


Ser Phe  Tyr Gln Gln Ile Lys  Arg Asn Ile Gly Gly  Lys His Ala 
    4880                 4885                 4890             


Arg Leu  Tyr Gln Thr Leu Asn  Glu Gly Lys Gln Leu  Val Ala Ser 
    4895                 4900                 4905             


Val Ser  Cys Pro Glu Leu Glu  Gly Gln Ile Ala Lys  Leu Glu Glu 
    4910                 4915                 4920             


Gln Trp  Leu Ser Leu Asn Lys  Lys Ile Asp His Glu  Leu His Arg 
    4925                 4930                 4935             


Leu Gln  Ala Leu Leu Lys His  Leu Leu Ser Tyr Asn  Arg Asp Ser 
    4940                 4945                 4950             


Asp Gln  Leu Thr Lys Trp Leu  Glu Ser Ser Gln His  Thr Leu Asn 
    4955                 4960                 4965             


Tyr Trp  Lys Glu Gln Ser Leu  Asn Val Ser Gln Asp  Leu Asp Thr 
    4970                 4975                 4980             


Ile Arg  Ser Asn Ile Asn Asn  Phe Phe Glu Phe Ser  Lys Glu Val 
    4985                 4990                 4995             


Asp Glu  Lys Ser Ser Leu Lys  Thr Ala Val Ile Ser  Ile Gly Asn 
    5000                 5005                 5010             


Gln Leu  Leu His Leu Lys Glu  Thr Asp Thr Ala Thr  Leu Arg Ala 
    5015                 5020                 5025             


Ser Leu  Ala Gln Phe Glu Gln  Lys Trp Thr Met Leu  Ile Thr Gln 
    5030                 5035                 5040             


Leu Pro  Asp Ile Gln Glu Lys  Leu His Gln Leu Gln  Met Glu Lys 
    5045                 5050                 5055             


Leu Pro  Ser Arg Lys Ala Ile  Thr Glu Met Ile Ser  Trp Met Asn 
    5060                 5065                 5070             


Asn Val  Glu His Gln Thr Ser  Asp Glu Asp Ser Val  His Ser Pro 
    5075                 5080                 5085             


Ser Ser  Ala Ser Gln Val Lys  His Leu Leu Gln Lys  His Lys Glu 
    5090                 5095                 5100             


Phe Arg  Met Glu Met Asp Tyr  Lys Gln Trp Ile Val  Asp Phe Val 
    5105                 5110                 5115             


Asn Gln  Ser Leu Leu Gln Leu  Ser Thr Cys Asp Val  Glu Ser Lys 
    5120                 5125                 5130             


Arg Tyr  Glu Arg Thr Glu Phe  Ala Glu His Leu Gly  Glu Met Asn 
    5135                 5140                 5145             


Arg Gln  Trp His Arg Val His  Gly Met Leu Asn Arg  Lys Ile Gln 
    5150                 5155                 5160             


His Leu  Glu Gln Leu Leu Glu  Ser Ile Thr Glu Ser  Glu Asn Lys 
    5165                 5170                 5175             


Ile Gln  Ile Leu Asn Asn Trp  Leu Glu Ala Gln Glu  Glu Arg Leu 
    5180                 5185                 5190             


Lys Thr  Leu Gln Lys Pro Glu  Ser Val Ile Ser Val  Gln Lys Leu 
    5195                 5200                 5205             


Leu Leu  Asp Cys Gln Asp Ile  Glu Asn Gln Leu Ala  Ile Lys Ser 
    5210                 5215                 5220             


Lys Ala  Leu Asp Glu Leu Lys  Gln Ser Tyr Leu Thr  Leu Glu Ser 
    5225                 5230                 5235             


Gly Ala  Val Pro Leu Leu Glu  Asp Thr Ala Ser Arg  Ile Asp Glu 
    5240                 5245                 5250             


Leu Phe  Gln Lys Arg Ser Ser  Val Leu Thr Gln Val  Asn Gln Leu 
    5255                 5260                 5265             


Lys Thr  Ser Met Gln Ser Val  Leu Gln Glu Trp Lys  Ile Tyr Asp 
    5270                 5275                 5280             


Gln Leu  Tyr Asp Glu Val Asn  Met Met Thr Ile Arg  Phe Trp Tyr 
    5285                 5290                 5295             


Cys Met  Glu His Ser Lys Pro  Val Val Leu Ser Leu  Glu Thr Leu 
    5300                 5305                 5310             


Arg Cys  Gln Val Glu Asn Leu  Gln Ser Leu Gln Asp  Glu Ala Glu 
    5315                 5320                 5325             


Ser Ser  Glu Gly Ser Trp Glu  Lys Leu Gln Glu Val  Ile Gly Lys 
    5330                 5335                 5340             


Leu Lys  Gly Leu Cys Pro Ser  Val Ala Glu Ile Ile  Glu Glu Lys 
    5345                 5350                 5355             


Cys Gln  Asn Thr His Lys Arg  Trp Thr Gln Val Asn  Gln Ala Ile 
    5360                 5365                 5370             


Ala Asp  Gln Leu Gln Lys Ala  Gln Ser Leu Leu Gln  Leu Trp Lys 
    5375                 5380                 5385             


Ala Tyr  Ser Asn Ala His Gly  Glu Ala Ala Ala Arg  Leu Lys Gln 
    5390                 5395                 5400             


Gln Glu  Ala Lys Phe Gln Gln  Leu Ala Asn Ile Ser  Met Ser Gly 
    5405                 5410                 5415             


Asn Asn  Leu Ala Glu Ile Leu  Pro Pro Ala Leu Gln  Asp Ile Lys 
    5420                 5425                 5430             


Glu Leu  Gln His Asp Val Gln  Lys Thr Lys Glu Ala  Phe Leu Gln 
    5435                 5440                 5445             


Asn Ser  Ser Val Leu Asp Arg  Leu Pro Gln Pro Ala  Glu Ser Ser 
    5450                 5455                 5460             


Thr His  Met Leu Leu Pro Gly  Pro Leu His Ser Leu  Gln Arg Ala 
    5465                 5470                 5475             


Ala Tyr  Leu Glu Lys Met Leu  Leu Val Lys Ala Asn  Glu Phe Glu 
    5480                 5485                 5490             


Phe Val  Leu Ser Gln Phe Lys  Asp Phe Gly Val Arg  Leu Glu Ser 
    5495                 5500                 5505             


Leu Lys  Gly Leu Ile Met His  Glu Glu Glu Asn Leu  Asp Arg Leu 
    5510                 5515                 5520             


His Gln  Gln Glu Lys Glu Asn  Pro Asp Ser Phe Leu  Asn His Val 
    5525                 5530                 5535             


Leu Ala  Leu Thr Ala Gln Ser  Pro Asp Ile Glu His  Leu Asn Glu 
    5540                 5545                 5550             


Val Ser  Leu Lys Leu Pro Leu  Ser Asp Val Ala Val  Lys Thr Leu 
    5555                 5560                 5565             


Gln Asn  Met Asn Arg Gln Trp  Ile Arg Ala Thr Ala  Thr Ala Leu 
    5570                 5575                 5580             


Glu Arg  Cys Ser Glu Leu Gln  Gly Ile Gly Leu Asn  Glu Lys Phe 
    5585                 5590                 5595             


Leu Tyr  Cys Cys Glu Lys Trp  Ile Gln Leu Leu Glu  Lys Ile Glu 
    5600                 5605                 5610             


Glu Ala  Leu Lys Val Asp Val  Ala Asn Ser Leu Pro  Glu Leu Leu 
    5615                 5620                 5625             


Glu Gln  Gln Lys Thr Tyr Lys  Met Leu Glu Ala Glu  Val Ser Ile 
    5630                 5635                 5640             


Asn Gln  Thr Ile Ala Asp Ser  Tyr Val Thr Gln Ser  Leu Gln Leu 
    5645                 5650                 5655             


Leu Asp  Thr Thr Glu Ile Glu  Asn Arg Pro Glu Phe  Ile Thr Glu 
    5660                 5665                 5670             


Phe Ser  Lys Leu Thr Asp Arg  Trp Gln Asn Ala Val  Gln Gly Val 
    5675                 5680                 5685             


Arg Gln  Arg Lys Gly Asp Val  Asp Gly Leu Val Arg  Gln Trp Gln 
    5690                 5695                 5700             


Asp Phe  Thr Thr Ser Val Glu  Asn Leu Phe Arg Phe  Leu Thr Asp 
    5705                 5710                 5715             


Thr Ser  His Leu Leu Ser Ala  Val Lys Gly Gln Glu  Arg Phe Ser 
    5720                 5725                 5730             


Leu Tyr  Gln Thr Arg Ser Leu  Ile His Glu Leu Lys  Asn Lys Glu 
    5735                 5740                 5745             


Ile His  Phe Gln Arg Arg Arg  Thr Thr Cys Ala Leu  Thr Leu Glu 
    5750                 5755                 5760             


Ala Gly  Glu Lys Leu Leu Leu  Thr Thr Asp Leu Lys  Thr Lys Glu 
    5765                 5770                 5775             


Ser Val  Gly Arg Arg Ile Ser  Gln Leu Gln Asp Ser  Trp Lys Asp 
    5780                 5785                 5790             


Met Glu  Pro Gln Leu Ala Glu  Met Ile Lys Gln Phe  Gln Ser Thr 
    5795                 5800                 5805             


Val Glu  Thr Trp Asp Gln Cys  Glu Lys Lys Ile Lys  Glu Leu Lys 
    5810                 5815                 5820             


Ser Arg  Leu Gln Val Leu Lys  Ala Gln Ser Glu Asp  Pro Leu Pro 
    5825                 5830                 5835             


Glu Leu  His Glu Asp Leu His  Asn Glu Lys Glu Leu  Ile Lys Glu 
    5840                 5845                 5850             


Leu Glu  Gln Ser Leu Ala Ser  Trp Thr Gln Asn Leu  Lys Glu Leu 
    5855                 5860                 5865             


Gln Thr  Met Lys Ala Asp Leu  Thr Arg His Val Leu  Val Glu Asp 
    5870                 5875                 5880             


Val Met  Val Leu Lys Glu Gln  Ile Glu His Leu His  Arg Gln Trp 
    5885                 5890                 5895             


Glu Asp  Leu Cys Leu Arg Val  Ala Ile Arg Lys Gln  Glu Ile Glu 
    5900                 5905                 5910             


Asp Arg  Leu Asn Thr Trp Val  Val Phe Asn Glu Lys  Asn Lys Glu 
    5915                 5920                 5925             


Leu Cys  Ala Trp Leu Val Gln  Met Glu Asn Lys Val  Leu Gln Thr 
    5930                 5935                 5940             


Ala Asp  Ile Ser Ile Glu Glu  Met Ile Glu Lys Leu  Gln Lys Asp 
    5945                 5950                 5955             


Cys Met  Glu Glu Ile Asn Leu  Phe Ser Glu Asn Lys  Leu Gln Leu 
    5960                 5965                 5970             


Lys Gln  Met Gly Asp Gln Leu  Ile Lys Ala Ser Asn  Lys Ser Arg 
    5975                 5980                 5985             


Ala Ala  Glu Ile Asp Asp Lys  Leu Asn Lys Ile Asn  Asp Arg Trp 
    5990                 5995                 6000             


Gln His  Leu Phe Asp Val Ile  Gly Ser Arg Val Lys  Lys Leu Lys 
    6005                 6010                 6015             


Glu Thr  Phe Ala Phe Ile Gln  Gln Leu Asp Lys Asn  Met Ser Asn 
    6020                 6025                 6030             


Leu Arg  Thr Trp Leu Ala Arg  Ile Glu Ser Glu Leu  Ser Lys Pro 
    6035                 6040                 6045             


Val Val  Tyr Asp Val Cys Asp  Asp Gln Glu Ile Gln  Lys Arg Leu 
    6050                 6055                 6060             


Ala Glu  Gln Gln Asp Leu Gln  Arg Asp Ile Glu Gln  His Ser Ala 
    6065                 6070                 6075             


Gly Val  Glu Ser Val Phe Asn  Ile Cys Asp Val Leu  Leu His Asp 
    6080                 6085                 6090             


Ser Asp  Ala Cys Ala Asn Glu  Thr Glu Cys Asp Ser  Ile Gln Gln 
    6095                 6100                 6105             


Thr Thr  Arg Ser Leu Asp Arg  Arg Trp Arg Asn Ile  Cys Ala Met 
    6110                 6115                 6120             


Ser Met  Glu Arg Arg Met Lys  Ile Glu Glu Thr Trp  Arg Leu Trp 
    6125                 6130                 6135             


Gln Lys  Phe Leu Asp Asp Tyr  Ser Arg Phe Glu Asp  Trp Leu Lys 
    6140                 6145                 6150             


Ser Ala  Glu Arg Thr Ala Ala  Cys Pro Asn Ser Ser  Glu Val Leu 
    6155                 6160                 6165             


Tyr Thr  Ser Ala Lys Glu Glu  Leu Lys Arg Phe Glu  Ala Phe Gln 
    6170                 6175                 6180             


Arg Gln  Ile His Glu Arg Leu  Thr Gln Leu Glu Leu  Ile Asn Lys 
    6185                 6190                 6195             


Gln Tyr  Arg Arg Leu Ala Arg  Glu Asn Arg Thr Asp  Thr Ala Ser 
    6200                 6205                 6210             


Arg Leu  Lys Gln Met Val His  Glu Gly Asn Gln Arg  Trp Asp Asn 
    6215                 6220                 6225             


Leu Gln  Arg Arg Val Thr Ala  Val Leu Arg Arg Leu  Arg His Phe 
    6230                 6235                 6240             


Thr Asn  Gln Arg Glu Glu Phe  Glu Gly Thr Arg Glu  Ser Ile Leu 
    6245                 6250                 6255             


Val Trp  Leu Thr Glu Met Asp  Leu Gln Leu Thr Asn  Val Glu His 
    6260                 6265                 6270             


Phe Ser  Glu Ser Asp Ala Asp  Asp Lys Met Arg Gln  Leu Asn Gly 
    6275                 6280                 6285             


Phe Gln  Gln Glu Ile Thr Leu  Asn Thr Asn Lys Ile  Asp Gln Leu 
    6290                 6295                 6300             


Ile Val  Phe Gly Glu Gln Leu  Ile Gln Lys Ser Glu  Pro Leu Asp 
    6305                 6310                 6315             


Ala Val  Leu Ile Glu Asp Glu  Leu Glu Glu Leu His  Arg Tyr Cys 
    6320                 6325                 6330             


Gln Glu  Val Phe Gly Arg Val  Ser Arg Phe His Arg  Arg Leu Thr 
    6335                 6340                 6345             


Ser Cys  Thr Pro Gly Leu Glu  Asp Glu Lys Glu Ala  Ser Glu Asn 
    6350                 6355                 6360             


Glu Thr  Asp Met Glu Asp Pro  Arg Glu Ile Gln Thr  Asp Ser Trp 
    6365                 6370                 6375             


Arg Lys  Arg Gly Glu Ser Glu  Glu Pro Ser Ser Pro  Gln Ser Leu 
    6380                 6385                 6390             


Cys His  Leu Val Ala Pro Gly  His Glu Arg Ser Gly  Cys Glu Thr 
    6395                 6400                 6405             


Pro Val  Ser Val Asp Ser Ile  Pro Leu Glu Trp Asp  His Thr Gly 
    6410                 6415                 6420             


Asp Val  Gly Gly Ser Ser Ser  His Glu Glu Asp Glu  Glu Gly Pro 
    6425                 6430                 6435             


Tyr Tyr  Ser Ala Leu Ser Gly  Lys Ser Ile Ser Asp  Gly His Ser 
    6440                 6445                 6450             


Trp His  Val Pro Asp Ser Pro  Ser Cys Pro Glu His  His Tyr Lys 
    6455                 6460                 6465             


Gln Met  Glu Gly Asp Arg Asn  Val Pro Pro Val Pro  Pro Ala Ser 
    6470                 6475                 6480             


Ser Thr  Pro Tyr Lys Pro Pro  Tyr Gly Lys Leu Leu  Leu Pro Pro 
    6485                 6490                 6495             


Gly Thr  Asp Gly Gly Lys Glu  Gly Pro Arg Val Leu  Asn Gly Asn 
    6500                 6505                 6510             


Pro Gln  Gln Glu Asp Gly Gly  Leu Ala Gly Ile Thr  Glu Gln Gln 
    6515                 6520                 6525             


Ser Gly  Ala Phe Asp Arg Trp  Glu Met Ile Gln Ala  Gln Glu Leu 
    6530                 6535                 6540             


His Asn  Lys Leu Lys Ile Lys  Gln Asn Leu Gln Gln  Leu Asn Ser 
    6545                 6550                 6555             


Asp Ile  Ser Ala Ile Thr Thr  Trp Leu Lys Lys Thr  Glu Ala Glu 
    6560                 6565                 6570             


Leu Glu  Met Leu Lys Met Ala  Lys Pro Pro Ser Asp  Ile Gln Glu 
    6575                 6580                 6585             


Ile Glu  Leu Arg Val Lys Arg  Leu Gln Glu Ile Leu  Lys Ala Phe 
    6590                 6595                 6600             


Asp Thr  Tyr Lys Ala Leu Val  Val Ser Val Asn Val  Ser Ser Lys 
    6605                 6610                 6615             


Glu Phe  Leu Gln Thr Glu Ser  Pro Glu Ser Thr Glu  Leu Gln Ser 
    6620                 6625                 6630             


Arg Leu  Arg Gln Leu Ser Leu  Leu Trp Glu Ala Ala  Gln Gly Ala 
    6635                 6640                 6645             


Val Asp  Ser Trp Arg Gly Gly  Leu Arg Gln Ser Leu  Met Gln Cys 
    6650                 6655                 6660             


Gln Asp  Phe His Gln Leu Ser  Gln Asn Leu Leu Leu  Trp Leu Ala 
    6665                 6670                 6675             


Ser Ala  Lys Asn Arg Arg Gln  Lys Ala His Val Thr  Asp Pro Lys 
    6680                 6685                 6690             


Ala Asp  Pro Arg Ala Leu Leu  Glu Cys Arg Arg Glu  Leu Met Gln 
    6695                 6700                 6705             


Leu Glu  Lys Glu Leu Val Glu  Arg Gln Pro Gln Val  Asp Met Leu 
    6710                 6715                 6720             


Gln Glu  Ile Ser Asn Ser Leu  Leu Ile Lys Gly His  Gly Glu Asp 
    6725                 6730                 6735             


Cys Ile  Glu Ala Glu Glu Lys  Val His Val Ile Glu  Lys Lys Leu 
    6740                 6745                 6750             


Lys Gln  Leu Arg Glu Gln Val  Ser Gln Asp Leu Met  Ala Leu Gln 
    6755                 6760                 6765             


Gly Thr  Gln Asn Pro Ala Ser  Pro Leu Pro Ser Phe  Asp Glu Val 
    6770                 6775                 6780             


Asp Ser  Gly Asp Gln Pro Pro  Ala Thr Ser Val Pro  Ala Pro Arg 
    6785                 6790                 6795             


Ala Lys  Gln Phe Arg Ala Val  Arg Thr Thr Glu Gly  Glu Glu Glu 
    6800                 6805                 6810             


Thr Glu  Ser Arg Val Pro Gly  Ser Thr Arg Pro Gln  Arg Ser Phe 
    6815                 6820                 6825             


Leu Ser  Arg Val Val Arg Ala  Ala Leu Pro Leu Gln  Leu Leu Leu 
    6830                 6835                 6840             


Leu Leu  Leu Leu Leu Leu Ala  Cys Leu Leu Pro Ser  Ser Glu Glu 
    6845                 6850                 6855             


Asp Tyr  Ser Cys Thr Gln Ala  Asn Asn Phe Ala Arg  Ser Phe Tyr 
    6860                 6865                 6870             


Pro Met  Leu Arg Tyr Thr Asn  Gly Pro Pro Pro Thr  
    6875                 6880                 6885 


<210>  104
<211>  975
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Thr Gln Gln Pro Gln Asp Asp Phe Asp Arg Ser Val Glu Asp Ala 
1               5                   10                  15      


Gln Ala Trp Met Lys Ala Val Gln Asp Gln Leu Gln Val Asn Asp Asn 
            20                  25                  30          


Thr Gln Gly Pro Arg Ala Ala Leu Glu Ala Arg Leu Trp Glu Thr Glu 
        35                  40                  45              


Lys Ile Cys Gln Leu Glu Pro Glu Gly Arg Val Arg Val Asp Leu Val 
    50                  55                  60                  


Leu Arg Met Ala Glu Ala Leu Leu Ala Cys Cys Pro Gly Asp Gln Lys 
65                  70                  75                  80  


Pro Gly Ile Leu Ala Arg Leu Lys Asp Ile Lys Ala Gln Trp Glu Glu 
                85                  90                  95      


Thr Val Thr Tyr Met Thr His Cys His Ser Arg Ile Glu Trp Val Trp 
            100                 105                 110         


Leu His Trp Ser Glu Tyr Leu Leu Ala Arg Asp Glu Phe Tyr Arg Trp 
        115                 120                 125             


Phe Gln Lys Met Met Val Thr Leu Glu Pro His Ile Glu Leu Gln Leu 
    130                 135                 140                 


Gly Leu Lys Glu Lys Gln Trp Gln Leu Ser His Ala Gln Val Leu Leu 
145                 150                 155                 160 


His Asn Val Asp Asn Gln Ala Val Leu Leu Asp Arg Leu Leu Glu Glu 
                165                 170                 175     


Ala Ala Ser Leu Phe Asn Arg Ile Gly Asp Pro Ser Val Asp Glu Asp 
            180                 185                 190         


Ala Gln Lys Arg Met Lys Ala Glu Tyr Asp Ala Val Lys Ala Lys Ala 
        195                 200                 205             


Gln Lys Arg Val Asp Leu Leu Glu Gln Val Ala Arg Glu His Glu Glu 
    210                 215                 220                 


Tyr Gln Ala Gly Val Asp Glu Phe Gln Leu Trp Leu Lys Ala Val Val 
225                 230                 235                 240 


Glu Lys Val Asn Gly Cys Leu Gly Arg Asn Cys Lys Leu Pro Ile Thr 
                245                 250                 255     


Gln Arg Leu Ser Thr Leu Gln Asp Ile Ala Lys Asp Phe Pro Arg Gly 
            260                 265                 270         


Glu Glu Ser Leu Glu Thr Leu Glu Glu Gln Ser Ala Gly Val Ile Arg 
        275                 280                 285             


Asn Thr Ser Pro Leu Gly Ala Glu Lys Ile Thr Gly Glu Leu Glu Glu 
    290                 295                 300                 


Met Arg Lys Val Leu Glu Lys Leu Arg Ala Leu Trp Glu Glu Glu Glu 
305                 310                 315                 320 


Glu Arg Leu Arg Gly Leu Leu Arg Ser Arg Gly Ala Trp Glu Gln Gln 
                325                 330                 335     


Ile Lys Gln Leu Glu Ala Glu Leu Ser Glu Phe Arg Met Val Leu Gln 
            340                 345                 350         


Arg Leu Ala Gln Glu Gly Leu Gln Pro Ala Ala Lys Ala Gly Thr Glu 
        355                 360                 365             


Asp Glu Leu Val Ala His Trp Arg Arg Tyr Ser Ala Thr Arg Ala Ala 
    370                 375                 380                 


Leu Ala Ser Glu Glu Pro Arg Val Asp Arg Leu Gln Ala Gln Leu Lys 
385                 390                 395                 400 


Glu Leu Ile Val Phe Pro His Asn Leu Lys Pro Leu Ser Asp Ser Val 
                405                 410                 415     


Ile Ala Thr Ile Gln Glu Tyr Gln Ser Leu Lys Val Lys Ser Ala Arg 
            420                 425                 430         


Leu Arg Asn Ala Ala Ala Val Glu Leu Trp Gln His Phe Gln Arg Pro 
        435                 440                 445             


Leu Gln Asp Leu Gln Leu Trp Lys Ala Leu Ala Gln Arg Leu Leu Glu 
    450                 455                 460                 


Val Thr Ala Ser Leu Pro Asp Leu Pro Ser Leu His Thr Phe Leu Pro 
465                 470                 475                 480 


Gln Ile Glu Ala Ala Leu Met Glu Ser Ser Arg Leu Lys Glu Leu Leu 
                485                 490                 495     


Thr Met Leu Gln Leu Lys Lys Asp Leu Leu Ile Gly Ile Phe Gly Gln 
            500                 505                 510         


Glu Arg Ala Thr Ala Leu Leu Glu Gln Val Ala Gly Ser Met Arg Asp 
        515                 520                 525             


Arg Asp Leu Leu His Asn Ser Leu Leu Gln Arg Lys Ser Lys Leu Gln 
    530                 535                 540                 


Ser Leu Leu Ala Gln His Lys Asp Phe Gly Ala Ala Phe Glu Pro Leu 
545                 550                 555                 560 


Gln Arg Lys Leu Leu Asp Leu Gln Val Arg Val Gln Ala Glu Lys Gly 
                565                 570                 575     


Leu Gln Arg Asp Leu Pro Gly Lys Gln Ala Gln Leu Ser Arg Leu Gln 
            580                 585                 590         


Gly Leu Gln Glu Glu Gly Leu Asp Leu Gly Ala Gln Met Glu Ala Ala 
        595                 600                 605             


Arg Pro Leu Val Gln Glu Asn Pro Asn His Gln His Lys Met Asp Gln 
    610                 615                 620                 


Leu Ser Ser Asp Phe Gln Ala Leu Gln Arg Ser Leu Glu Asp Leu Val 
625                 630                 635                 640 


Asp Arg Cys Arg Gln Ser Val Gln Glu His Cys Thr Phe Ser His Gln 
                645                 650                 655     


Leu Leu Glu Leu Arg Gln Trp Ile Val Val Thr Thr Gln Lys Leu Glu 
            660                 665                 670         


Ala His Arg Gly Glu Ala Gly Pro Gly Asp Ala Glu Ser Gln Glu Ala 
        675                 680                 685             


Glu Phe Glu Arg Leu Val Ala Glu Phe Pro Glu Lys Glu Ala Gln Leu 
    690                 695                 700                 


Ser Leu Val Glu Ala Gln Gly Trp Leu Val Met Glu Lys Ser Ser Pro 
705                 710                 715                 720 


Glu Gly Ala Ala Val Val Gln Glu Glu Leu Arg Glu Leu Ala Glu Ser 
                725                 730                 735     


Trp Arg Ala Leu Arg Leu Leu Glu Glu Ser Leu Leu Ser Leu Ile Arg 
            740                 745                 750         


Asn Trp His Leu Gln Arg Met Glu Val Asp Ser Gly Lys Lys Met Val 
        755                 760                 765             


Phe Thr Asn Asn Ile Pro Lys Ser Gly Phe Leu Ile Asn Pro Met Asp 
    770                 775                 780                 


Pro Ile Pro Arg His Arg Arg Arg Ala Asn Leu Leu Gln Glu Glu Glu 
785                 790                 795                 800 


Gly Ser His Glu Asp Phe Ser Gln Leu Leu Arg Asn Phe Gly Gln Trp 
                805                 810                 815     


Leu Gln Val Glu Asn Ser Lys Leu Val Arg Ile Ile Ala Met Arg Thr 
            820                 825                 830         


Ser Thr Ala Glu Asp Leu Arg Thr Arg Lys Ser Lys Leu Gln Glu Leu 
        835                 840                 845             


Glu Ala Arg Val Pro Glu Gly Gln His Leu Phe Glu Asn Leu Leu Arg 
    850                 855                 860                 


Leu Gly Pro Ala Arg Gly Thr Ser Asp Glu Leu Glu Asp Leu Arg Tyr 
865                 870                 875                 880 


Gln Trp Met Leu Tyr Lys Ser Lys Leu Lys Asp Ser Gly His Leu Leu 
                885                 890                 895     


Thr Gln Ser Ser Pro Gly Glu Pro Thr Gly Phe Gln Lys Thr Arg Arg 
            900                 905                 910         


Trp Arg Gly Leu Gly Ser Leu Phe Arg Arg Ala Cys Cys Val Ala Leu 
        915                 920                 925             


Pro Leu Gln Leu Leu Leu Leu Leu Phe Leu Leu Leu Leu Phe Leu Leu 
    930                 935                 940                 


Pro Ile Arg Glu Glu Asp Arg Ser Cys Thr Leu Ala Asn Asn Phe Ala 
945                 950                 955                 960 


Arg Ser Phe Thr Leu Met Leu Arg Tyr Asn Gly Pro Pro Pro Thr 
                965                 970                 975 


<210>  105
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Ala Leu Ser Leu Pro Leu Gly Pro Arg Leu Gly Ser Glu Pro Leu 
1               5                   10                  15      


Asn His Pro Pro Gly Ala Pro Arg Glu Ala Asp Ile Val Gly Cys Thr 
            20                  25                  30          


Val Cys Pro Ala Ser Gly Glu Glu Ser Thr Ser Pro Glu Gln Ala Gln 
        35                  40                  45              


Thr Leu Gly Gln Asp Ser Leu Gly Pro Pro Glu His Phe Gln Gly Gly 
    50                  55                  60                  


Pro Arg Gly Asn Glu Pro Ala Ala His Pro Pro Arg Trp Ser Thr Pro 
65                  70                  75                  80  


Ser Ser Tyr Glu Asp Pro Ala Gly Gly Lys His Cys Glu His Pro Ile 
                85                  90                  95      


Ser Gly Leu Glu Val Leu Glu Ala Glu Gln Asn Ser Leu His Leu Cys 
            100                 105                 110         


Leu Leu Gly Leu Gly Arg Arg Leu Gln Asp Leu Glu Gln Gly Leu Gly 
        115                 120                 125             


His Trp Ala Leu Ala Gln Ser Gly Met Val Gln Leu Gln Ala Leu Gln 
    130                 135                 140                 


Val Asp Leu Arg Gly Ala Ala Glu Arg Val Glu Ala Leu Leu Ala Phe 
145                 150                 155                 160 


Gly Glu Gly Leu Ala Gln Arg Ser Glu Pro Arg Ala Trp Ala Ala Leu 
                165                 170                 175     


Glu Gln Ile Leu Arg Ala Leu Gly Ala Tyr Arg Asp Ser Ile Phe Arg 
            180                 185                 190         


Arg Leu Trp Gln Leu Gln Ala Gln Leu Val Ser Tyr Ser Leu Val Phe 
        195                 200                 205             


Glu Glu Ala Asn Thr Leu Asp Gln Asp Leu Glu Val Glu Gly Asp Ser 
    210                 215                 220                 


Asp Trp Pro Gly Pro Gly Gly Val Trp Gly Pro Trp Ala Pro Ser Ser 
225                 230                 235                 240 


Leu Pro Thr Ser Thr Glu Leu Glu Trp Asp Pro Ala Gly Asp Ile Gly 
                245                 250                 255     


Gly Leu Gly Pro Leu Gly Gln Lys Thr Ala Arg Thr Leu Gly Val Pro 
            260                 265                 270         


Cys Glu Leu Cys Gly Gln Arg Gly Pro Gln Gly Arg Gly Gln Gly Leu 
        275                 280                 285             


Glu Glu Ala Asp Thr Ser His Ser Arg Gln Asp Met Leu Glu Ser Gly 
    290                 295                 300                 


Leu Gly His Gln Lys Arg Leu Ala Arg His Gln Arg His Ser Leu Leu 
305                 310                 315                 320 


Arg Lys Pro Gln Asp Lys Lys Arg Gln Ala Ser Pro His Leu Gln Asp 
                325                 330                 335     


Val Arg Leu Glu Gly Asn Pro Gly Ala Pro Asp Pro Ala Ser Arg Gln 
            340                 345                 350         


Pro Leu Thr Phe Leu Leu Ile Leu Phe Leu Leu Phe Leu Leu Leu Val 
        355                 360                 365             


Gly Ala Met Phe Leu Leu Pro Ala Ser Gly Gly Pro Cys Cys Ser His 
    370                 375                 380                 


Ala Arg Ile Pro Arg Thr Pro Tyr Leu Val Leu Ser Tyr Val Asn Gly 
385                 390                 395                 400 


Leu Pro Pro Val 
                


<210>  106
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Asp Leu Pro Glu Gly Pro Val Gly Gly Pro Thr Ala Glu Met Tyr 
1               5                   10                  15      


Leu Arg Glu Arg Pro Glu Glu Ala Arg Leu Gly Met Pro Val Ser Leu 
            20                  25                  30          


Glu Glu Gln Ile Leu Asn Ser Thr Phe Glu Ala Cys Asp Pro Gln Arg 
        35                  40                  45              


Thr Gly Thr Val Ala Val Ala Gln Val Leu Ala Tyr Leu Glu Ala Val 
    50                  55                  60                  


Thr Gly Gln Gly Pro Gln Asp Ala Arg Leu Gln Thr Leu Ala Asn Ser 
65                  70                  75                  80  


Leu Asp Pro Asn Gly Glu Gly Pro Lys Ala Thr Val Asp Leu Asp Thr 
                85                  90                  95      


Phe Leu Val Val Met Arg Asp Trp Ile Ala Ala Cys Gln Leu His Gly 
            100                 105                 110         


Gly Leu Glu Leu Glu Glu Glu Thr Ala Phe Gln Gly Ala Leu Thr Ser 
        115                 120                 125             


Arg Gln Leu Pro Ser Gly Cys Pro Glu Ala Glu Glu Pro Ala Asn Leu 
    130                 135                 140                 


Glu Ser Phe Gly Gly Glu Asp Pro Arg Pro Glu Leu Gln Ala Thr Ala 
145                 150                 155                 160 


Asp Leu Leu Ser Ser Leu Glu Asp Leu Glu Leu Ser Asn Arg Arg Leu 
                165                 170                 175     


Val Gly Glu Asn Ala Lys Leu Gln Arg Ser Met Glu Thr Ala Glu Glu 
            180                 185                 190         


Gly Ser Ala Arg Leu Gly Glu Glu Ile Leu Ala Leu Arg Lys Gln Leu 
        195                 200                 205             


His Ser Thr Gln Gln Ala Leu Gln Phe Ala Lys Ala Met Asp Glu Glu 
    210                 215                 220                 


Leu Glu Asp Leu Lys Thr Leu Ala Arg Ser Leu Glu Glu Gln Asn Arg 
225                 230                 235                 240 


Ser Leu Leu Ala Gln Ala Arg Gln Ala Glu Lys Glu Gln Gln His Leu 
                245                 250                 255     


Val Ala Glu Met Glu Thr Leu Gln Glu Glu Asn Gly Lys Leu Leu Ala 
            260                 265                 270         


Glu Arg Asp Gly Val Lys Lys Arg Ser Gln Glu Leu Ala Met Glu Lys 
        275                 280                 285             


Asp Thr Leu Lys Arg Gln Leu Phe Glu Cys Glu His Leu Ile Cys Gln 
    290                 295                 300                 


Arg Asp Thr Ile Leu Ser Glu Arg Thr Arg Asp Val Glu Ser Leu Ala 
305                 310                 315                 320 


Gln Thr Leu Glu Glu Tyr Arg Val Thr Thr Gln Glu Leu Arg Leu Glu 
                325                 330                 335     


Ile Ser Arg Leu Glu Glu Gln Leu Ser Gln Thr Tyr Glu Gly Pro Asp 
            340                 345                 350         


Glu Leu Pro Glu Gly Ala Gln Leu Arg Arg Val Gly Trp Thr Glu Leu 
        355                 360                 365             


Leu Pro Pro Ser Leu Gly Leu Glu Ile Glu Ala Ile Arg Gln Lys Gln 
    370                 375                 380                 


Glu Val Ala Thr Ala Asp Leu Ser Asn Pro Leu Cys Gly Val Trp Gln 
385                 390                 395                 400 


Trp Glu Glu Val Ile His Glu Thr Ser Glu Glu Thr Glu Phe Pro Ser 
                405                 410                 415     


Glu Ala Pro Ala Gly Gly Gln Arg Asn Phe Gln Gly Glu Pro Ala His 
            420                 425                 430         


Pro Glu Glu Gly Arg Lys Glu Pro Ser Met Trp Leu Thr Arg Arg Glu 
        435                 440                 445             


Glu Glu Glu Asp Ala Glu Ser Gln Val Thr Ala Asp Leu Pro Val Pro 
    450                 455                 460                 


Leu Gly Ala Pro Arg Pro Gly Asp Ile Pro Glu Asn Pro Pro Glu Arg 
465                 470                 475                 480 


Pro Ala Arg Arg Glu Leu Gln Gln Ala Leu Val Pro Val Met Lys Lys 
                485                 490                 495     


Leu Val Pro Val Arg Arg Arg Ala Trp Gly Gln Leu Cys Leu Pro Pro 
            500                 505                 510         


Gln Arg Leu Arg Val Thr Arg His Pro Leu Ile Pro Ala Pro Val Leu 
        515                 520                 525             


Gly Leu Leu Leu Leu Leu Leu Leu Ser Val Leu Leu Leu Gly Pro Ser 
    530                 535                 540                 


Pro Pro Pro Thr Trp Pro His Leu Gln Leu Cys Tyr Leu Gln Pro Pro 
545                 550                 555                 560 


Pro Val 
        


<210>  107
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Ala Thr Ser Arg Gly Ala Ser Arg Cys Pro Arg Asp Ile Ala Asn 
1               5                   10                  15      


Val Met Gln Arg Leu Gln Asp Glu Gln Glu Ile Val Gln Lys Arg Thr 
            20                  25                  30          


Phe Thr Lys Trp Ile Asn Ser His Leu Ala Lys Arg Lys Pro Pro Met 
        35                  40                  45              


Val Val Asp Asp Leu Phe Glu Asp Met Lys Asp Gly Val Lys Leu Leu 
    50                  55                  60                  


Ala Leu Leu Glu Val Leu Ser Gly Gln Lys Leu Pro Cys Glu Gln Gly 
65                  70                  75                  80  


Arg Arg Met Lys Arg Ile His Ala Val Ala Asn Ile Gly Thr Ala Leu 
                85                  90                  95      


Lys Phe Leu Glu Gly Arg Lys Ile Lys Leu Val Asn Ile Asn Ser Thr 
            100                 105                 110         


Asp Ile Ala Asp Gly Arg Pro Ser Ile Val Leu Gly Leu Met Trp Thr 
        115                 120                 125             


Ile Ile Leu Tyr Phe Gln Ile Glu Glu Leu Thr Ser Asn Leu Pro Gln 
    130                 135                 140                 


Leu Gln Ser Leu Ser Ser Ser Ala Ser Ser Val Asp Ser Ile Val Ser 
145                 150                 155                 160 


Ser Glu Thr Pro Ser Pro Pro Ser Lys Arg Lys Val Thr Thr Lys Ile 
                165                 170                 175     


Gln Gly Asn Ala Lys Lys Ala Leu Leu Lys Trp Val Gln Tyr Thr Ala 
            180                 185                 190         


Gly Lys Gln Thr Gly Ile Glu Val Lys Asp Phe Gly Lys Ser Trp Arg 
        195                 200                 205             


Ser Gly Val Ala Phe His Ser Val Ile His Ala Ile Arg Pro Glu Leu 
    210                 215                 220                 


Val Asp Leu Glu Thr Val Lys Gly Arg Ser Asn Arg Glu Asn Leu Glu 
225                 230                 235                 240 


Asp Ala Phe Thr Ile Ala Glu Thr Glu Leu Gly Ile Pro Arg Leu Leu 
                245                 250                 255     


Asp Pro Glu Asp Val Asp Val Asp Lys Pro Asp Glu Lys Ser Ile Met 
            260                 265                 270         


Thr Tyr Val Ala Gln Phe Leu Lys His Tyr Pro Asp Ile His Asn Ala 
        275                 280                 285             


Ser 
    


<210>  108
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Ala Ser Ser Pro Glu Leu Pro Thr Glu Asp Glu Gln Gly Ser Trp 
1               5                   10                  15      


Gly Ile Asp Asp Leu His Ile Ser Leu Gln Ala Glu Gln Glu Asp Thr 
            20                  25                  30          


Gln Lys Lys Ala Phe Thr Cys Trp Ile Asn Ser Gln Leu Ala Arg His 
        35                  40                  45              


Thr Ser Pro Ser Val Ile Ser Asp Leu Phe Thr Asp Ile Lys Lys Gly 
    50                  55                  60                  


His Val Leu Leu Asp Leu Leu Glu Val Leu Ser Gly Gln Gln Leu Pro 
65                  70                  75                  80  


Arg Asp Lys Gly Ser Asn Thr Phe Gln Cys Arg Ile Asn Ile Glu His 
                85                  90                  95      


Ala Leu Thr Phe Leu Arg Asn Arg Ser Ile Lys Leu Ile Asn Ile His 
            100                 105                 110         


Val Thr Asp Ile Ile Asp Gly Asn Pro Ser Ile Ile Leu Gly Leu Ile 
        115                 120                 125             


Trp Thr Ile Ile Leu His Phe His Ile Glu Lys Leu Ala Gln Thr Leu 
    130                 135                 140                 


Ser Cys Asn Tyr Asn Gln Pro Ser Leu Asp Asp Val Ser Val Val Asp 
145                 150                 155                 160 


Ser Ser Pro Ala Ser Ser Pro Pro Ala Lys Lys Cys Ser Lys Val Gln 
                165                 170                 175     


Ala Arg Trp Gln Met Ser Ala Arg Lys Ala Leu Leu Leu Trp Ala Gln 
            180                 185                 190         


Glu Gln Cys Ala Thr Tyr Glu Ser Val Asn Val Thr Asp Phe Lys Ser 
        195                 200                 205             


Ser Trp Arg Asn Gly Met Ala Phe Leu Ala Ile Ile His Ala Leu Arg 
    210                 215                 220                 


Pro Asp Leu Ile Asp Met Lys Ser Val Lys His Arg Ser Asn Lys Asp 
225                 230                 235                 240 


Asn Leu Arg Glu Ala Phe Arg Ile Ala Glu Gln Glu Leu Lys Ile Pro 
                245                 250                 255     


Arg Leu Leu Glu Pro Glu Asp Val Asp Val Val Asp Pro Asp Glu Lys 
            260                 265                 270         


Ser Ile Met Thr Tyr Val Ala Gln Phe Leu Gln Tyr Ser Lys 
        275                 280                 285     


<210>  109
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LMNA-targeted guide RNA

<400>  109
aggagatgga tccgcccacc                                                   20


<210>  110
<211>  131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lmna-G609G progeria mutation repair oligo

<400>  110
gtgctgtgcg ggacgtgtgg gcagcctgct gacaaggctg ccggtggagc gggagcccag       60

gtgggtggat ccatctcctc tggctcttct gcctccagtg tcacagtcac tcgaagcttc      120

cgcagtgtgg g                                                           131


<210>  111
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lmna GT up

<400>  111
ccacaggtct cccaagtccc catc                                              24


<210>  112
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lmna GT down

<400>  112
tcctctccct ccctgacccc aaa                                               23


<210>  113
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Glu Ser Thr Pro Phe Ser Gly Val Ala Asn Gln Ile His Thr Leu 
1               5                   10                  15      


Cys Glu Arg Pro Thr Tyr Gly Glu Val Lys Asp Gly Ala Leu Asp Val 
            20                  25                  30          


Lys Arg Gln His Lys Cys Pro Gly Pro Thr Ser Gly Pro Ser Pro Gly 
        35                  40                  45              


Thr Asn Leu Ser Gly Cys Ile Arg Met Asn Asp Asp Pro Ser Met Glu 
    50                  55                  60                  


Glu Asn Gly Val Glu Arg Val Cys Pro Glu Ser Leu Leu Gln Ser Arg 
65                  70                  75                  80  


Glu Tyr Ser Ser Leu Pro Leu Pro Arg His Thr Ser Ser Thr Asp Gly 
                85                  90                  95      


Thr Ile Thr Ser Ser Asp Pro Gly Leu Glu Ile Leu Asn Met Ala Ser 
            100                 105                 110         


Cys Asp Leu Asp Arg Asn Ser Leu Cys Lys Lys Glu Glu Asp Thr Arg 
        115                 120                 125             


Ser Ala Ser Pro Thr Ile Glu Ala Gln Gly Thr Ser Pro Ala His Asp 
    130                 135                 140                 


Asn Ile Ala Phe Gln Asp Ser Thr Ser Lys Asp Lys Thr Ile Leu Asn 
145                 150                 155                 160 


Leu Glu Ala Lys Glu Glu Pro Glu Thr Ile Glu Glu His Lys Lys Glu 
                165                 170                 175     


His Ala Ser Gly Asp Ser Val Val Ser Pro Leu Pro Val Thr Thr Val 
            180                 185                 190         


Lys Ser Val Asn Leu Arg Gln Ser Glu Asn Thr Ser Ala Asn Glu Lys 
        195                 200                 205             


Glu Val Glu Ala Glu Phe Leu Arg Leu Ser Leu Gly Phe Lys Cys Asp 
    210                 215                 220                 


Trp Phe Thr Leu Glu Lys Arg Val Lys Leu Glu Glu Arg Ser Arg Asp 
225                 230                 235                 240 


Leu Ala Glu Glu Asn Leu Lys Lys Glu Ile Thr Asn Cys Leu Lys Leu 
                245                 250                 255     


Leu Glu Ser Leu Thr Pro Leu Cys Glu Asp Asp Asn Gln Ala Gln Glu 
            260                 265                 270         


Ile Ile Lys Lys Leu Glu Lys Ser Ile Lys Phe Leu Ser Gln Cys Ala 
        275                 280                 285             


Ala Arg Val Ala Ser Arg Ala Glu Met Leu Gly Ala Ile Asn Gln Glu 
    290                 295                 300                 


Ser Arg Val Ser Lys Ala Val Glu Val Met Ile Gln His Val Glu Asn 
305                 310                 315                 320 


Leu Lys Arg Met Tyr Ala Lys Glu His Ala Glu Leu Glu Glu Leu Lys 
                325                 330                 335     


Gln Val Leu Leu Gln Asn Glu Arg Ser Phe Asn Pro Leu Glu Asp Asp 
            340                 345                 350         


Asp Asp Cys Gln Ile Lys Lys Arg Ser Ala Ser Leu Asn Ser Lys Pro 
        355                 360                 365             


Ser Ser Leu Arg Arg Val Thr Ile Ala Ser Leu Pro Arg Asn Ile Gly 
    370                 375                 380                 


Asn Ala Gly Met Val Ala Gly Met Glu Asn Asn Asp Arg Phe Ser Arg 
385                 390                 395                 400 


Arg Ser Ser Ser Trp Arg Ile Leu Gly Ser Lys Gln Ser Glu His Arg 
                405                 410                 415     


Pro Ser Leu Pro Arg Phe Ile Ser Thr Tyr Ser Trp Ala Asp Ala Glu 
            420                 425                 430         


Glu Glu Lys Cys Glu Leu Lys Thr Lys Asp Asp Ser Glu Pro Ser Gly 
        435                 440                 445             


Glu Glu Thr Val Glu Arg Thr Arg Lys Pro Ser Leu Ser Glu Lys Lys 
    450                 455                 460                 


Asn Asn Pro Ser Lys Trp Asp Val Ser Ser Val Tyr Asp Thr Ile Ala 
465                 470                 475                 480 


Ser Trp Ala Thr Asn Leu Lys Ser Ser Ile Arg Lys Ala Asn Lys Ala 
                485                 490                 495     


Leu Trp Leu Ser Ile Ala Phe Ile Val Leu Phe Ala Ala Leu Met Ser 
            500                 505                 510         


Phe Leu Thr Gly Gln Leu Phe Gln Lys Ser Val Asp Ala Ala Pro Thr 
        515                 520                 525             


Gln Gln Glu Asp Ser Trp Thr Ser Leu Glu His Ile Leu Trp Pro Phe 
    530                 535                 540                 


Thr Arg Leu Arg His Asn Gly Pro Pro Pro Val 
545                 550                 555 


<210>  114
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  114

Gln Leu Phe Gln Lys Ser Val Asp Ala Ala Pro Thr Gln Gln Glu Asp 
1               5                   10                  15      


Ser Trp Thr Ser Leu Glu His Ile Leu Trp Pro Phe Thr Arg Leu Arg 
            20                  25                  30          


His Asn Gly Pro Pro Pro Val 
        35                  


<210>  115
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SUN1 SUN domain plus upstream alpha3 region

<400>  115

Gly Ile Thr Glu Ala Gln Ala Arg Ala Ile Val Asn Ser Ala Leu Lys 
1               5                   10                  15      


Leu Tyr Ser Gln Asp Lys Thr Gly Met Val Asp Phe Ala Leu Glu Ser 
            20                  25                  30          


Gly Gly Gly Ser Ile Leu Ser Thr Arg Cys Ser Glu Thr Tyr Glu Thr 
        35                  40                  45              


Lys Thr Ala Leu Met Ser Leu Phe Gly Ile Pro Leu Trp Tyr Phe Ser 
    50                  55                  60                  


Gln Ser Pro Arg Val Val Ile Gln Pro Asp Ile Tyr Pro Gly Asn Cys 
65                  70                  75                  80  


Trp Ala Phe Lys Gly Ser Gln Gly Tyr Leu Val Val Arg Leu Ser Met 
                85                  90                  95      


Met Ile His Pro Ala Ala Phe Thr Leu Glu His Ile Pro Lys Thr Leu 
            100                 105                 110         


Ser Pro Thr Gly Asn Ile Ser Ser Ala Pro Lys Asp Phe Ala Val Tyr 
        115                 120                 125             


Gly Leu Glu Asn Glu Tyr Gln Glu Glu Gly Gln Leu Leu Gly Gln Phe 
    130                 135                 140                 


Thr Tyr Asp Gln Asp Gly Glu Ser Leu Gln Met Phe Gln Ala Leu Lys 
145                 150                 155                 160 


Arg Pro Asp Asp Thr Ala Phe Gln Ile Val Glu Leu Arg Ile Phe Ser 
                165                 170                 175     


Asn Trp Gly His Pro Glu Tyr Thr Cys Leu Tyr Arg Phe Arg Val His 
            180                 185                 190         


Gly Glu Pro Val Lys 
        195         


<210>  116
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SUN2 SUN domain plus upstream ?3 region

<400>  116

Gly Val Thr Glu Glu Gln Val His His Ile Val Lys Gln Ala Leu Gln 
1               5                   10                  15      


Arg Tyr Ser Glu Asp Arg Ile Gly Leu Ala Asp Tyr Ala Leu Glu Ser 
            20                  25                  30          


Gly Gly Ala Ser Val Ile Ser Thr Arg Cys Ser Glu Thr Tyr Glu Thr 
        35                  40                  45              


Lys Thr Ala Leu Leu Ser Leu Phe Gly Ile Pro Leu Trp Tyr His Ser 
    50                  55                  60                  


Gln Ser Pro Arg Val Ile Leu Gln Pro Asp Val His Pro Gly Asn Cys 
65                  70                  75                  80  


Trp Ala Phe Gln Gly Pro Gln Gly Phe Ala Val Val Arg Leu Ser Ala 
                85                  90                  95      


Arg Ile Arg Pro Thr Ala Val Thr Leu Glu His Val Pro Lys Ala Leu 
            100                 105                 110         


Ser Pro Asn Ser Thr Ile Ser Ser Ala Pro Lys Asp Phe Ala Ile Phe 
        115                 120                 125             


Gly Phe Asp Glu Asp Leu Gln Gln Glu Gly Thr Leu Leu Gly Lys Phe 
    130                 135                 140                 


Thr Tyr Asp Gln Asp Gly Glu Pro Ile Gln Thr Phe His Phe Gln Ala 
145                 150                 155                 160 


Pro Thr Met Ala Thr Tyr Gln Val Val Glu Leu Arg Ile Leu Thr Asn 
                165                 170                 175     


Trp Gly His Pro Glu Tyr Thr Cys Ile Tyr Arg Phe Arg Val His Gly 
            180                 185                 190         


Glu Pro Ala His 
        195     


<210>  117
<211>  168
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gBlock humanized SUN1 dominant negative megaprimer

<400>  117
tataggctag cggcacaatg aagtgggtaa cctttatttc ccttcttttt ctctttagct       60

cggcctattc caggggtgtg tttcgtcgag atgggccctc cggaggtgaa caaaaactca      120

tctcagaaga ggatctcacc ggtggagatg agggctggga agccagag                   168


<210>  118
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gBlock amiplification F primer

<400>  118
tataggctag cggcacaatg                                                   20


<210>  119
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gBlock amiplification R primer

<400>  119
ctctggcttc ccagccctca                                                   20


<210>  120
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SUN2 lumenal domain R primer

<400>  120
ccgggtcgac ctacaactca tctttgtggg cgggctcccc atgcac                      46


<210>  121
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SUN1 lumenal domain F primer

<400>  121
tctcaccggt ggagatgacc cccaggacgt gtttaaac                               38


<210>  122
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SUN1 lumenal domain R primer

<400>  122
ccgggtcgac ctacaactca tctttcttga caggttcgcc atgaactc                    48


<210>  123
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  qRT-PCR F primer for viral genome quantification

<400>  123
acagtctcga acttaagctg ca                                                22


<210>  124
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  qRT-PCR R primer for viral genome quantification

<400>  124
gtctcgacaa gcccagtttc ta                                                22


<210>  125
<211>  5695
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAAV-cTnT-MYC-SUN1DN

<400>  125
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gaattcgccc ttacgggccc cccctcgagg tcgggataaa      240

agcagtctgg gctttcacat gacagcatct ggggctgcgg cagagggtcg ggtccgaagc      300

gctgccttat cagcgtcccc agccctggga ggtgacagct ggctggcttg tgtcagcccc      360

tcgggcactc acgtatctcc gtccgacggg tttaaaatag caaaactctg aggccacaca      420

atagcttggg cttatatggg ctcctgtggg ggaaggggga gcacggaggg ggccggggcc      480

gctgctgcca aaatagcagc tcacaagtgt tgcattcctc tctgggcgcc gggcacattc      540

ctgctggctc tgcccgcccc ggggtgggcg ccggggggac cttaaagcct ctgcccccca      600

aggagccctt cccagacagc cgccggcacc caccgctccg tgggacgatc cccgaagctc      660

tagagcttta ttgcggtagt ttatcacagt taaattgcta acgcagtcag tgcttctgac      720

acaacagtct cgaacttaag ctgcagaagt tggtcgtgag gcactgggca ggtaagtatc      780

aaggttacaa gacaggttta aggagaccaa tagaaactgg gcttgtcgag acagagaaga      840

ctcttgcgtt tctgataggc acctattggt cttactgaca tccactttgc ctttctctcc      900

acaggtgtcc actcccagtt caattacagc tcttaaggct agagtactta atacgactca      960

ctataggcta gcggcacaat gaagtgggta acctttattt cccttctttt tctctttagc     1020

tcggcctatt ccaggggtgt gtttcgtcga gatgggccct ccggaggtga acaaaaactc     1080

atctcagaag aggatctcac cggtggagat gacccccagg acgtgtttaa acccacgact     1140

tctcgcctga agcagcctct gcagggtgac agtgaggctt ttccgtggca ttggatgagt     1200

ggcgtggagc agcaggtggc ctctctgtct ggacagtgcc accaccatgg tgagaatctc     1260

cgagagctga ccactttgct acagaagctg caggctcggg tggaccagat ggaaggcggc     1320

gctgccgggc cgtcagcttc ggtcagagac gctgtgggac agcccccgag ggagactgac     1380

tttatggcct ttcaccaaga acatgaagtg cgtatgtcac acttggaaga tattctggga     1440

aaactgagag aaaaatctga ggccatccag aaggaactag aacagaccaa gcaaaaaaca     1500

atcagtgcgg ttggtgagca gctcctgccc acagtcgagc acctccagct ggagctggat     1560

cagctaaagt cagagctgtc cagctggcga cacgtgaaga ccggctgtga gacagtggat     1620

gccgtacaag aaagagtgga cgtgcaagtc agagaaatgg tgaaactcct gttttccgaa     1680

gatcagcaag gcggttctct ggaacagctg ctgcagaggt tctcatcaca gtttgtgagc     1740

aaaggcgact tgcagacgat gctgcgagac ctgcagctgc agatcctgcg gaacgtcacc     1800

caccacgttt ccgtgaccaa gcagctccca acctcagaag ccgtggtgtc tgctgtgagc     1860

gaggcggggg cgtctggaat aacagaggcg caagcacgtg ccatcgtgaa cagcgccttg     1920

aagctgtatt cccaagataa gaccgggatg gtggactttg ctctggaatc tggtggtggc     1980

agcatcttga gtactcgctg ttctgaaact tacgaaacca aaacggcgct gatgagtctg     2040

tttgggatcc cgctgtggta cttctcgcag tccccgcgcg tggtcatcca gcctgacatt     2100

taccccggta actgctgggc atttaaaggc tcccaggggt acctggtggt gaggctctcc     2160

atgatgatcc acccagccgc cttcactctg gagcacatcc ctaagacgct gtcgccaaca     2220

ggcaacatca gcagcgcccc caaggacttc gccgtctatg gattagaaaa tgagtatcag     2280

gaagaagggc agcttctggg acagttcacg tatgatcagg atggggagtc gctccagatg     2340

ttccaggccc tgaaaagacc cgacgacaca gctttccaaa tagtggaact tcggattttt     2400

tctaactggg gccatcctga gtatacctgt ctgtatcggt tcagagttca tggcgaacct     2460

gtcaagaaag atgagttgta ggtcgacccg ggcggcctcg aggacggggt gaactacgcc     2520

tgaggatccg atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag     2580

catctgactt ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt     2640

ttgtgtctct cactcggaag caattcgttg atctgaattt cgaccaccca taatacccat     2700

taccctggta gataagtagc atggcgggtt aatcattaac tacaaggaac ccctagtgat     2760

ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt     2820

cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcagccttaa     2880

ttaacctaat tcactggccg tcgttttaca acgtcgtgac tgggaaaacc ctggcgttac     2940

ccaacttaat cgccttgcag cacatccccc tttcgccagc tggcgtaata gcgaagaggc     3000

ccgcaccgat cgcccttccc aacagttgcg cagcctgaat ggcgaatggg acgcgccctg     3060

tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg ctacacttgc     3120

cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca cgttcgccgg     3180

ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta gtgctttacg     3240

gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtagtgggc catcgccctg     3300

atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg gactcttgtt     3360

ccaaactgga acaacactca accctatctc ggtctattct tttgatttat aagggatttt     3420

gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta acgcgaattt     3480

taacaaaata ttaacgctta caatttaggt ggcacttttc ggggaaatgt gcgcggaacc     3540

cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc     3600

tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc     3660

gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc agaaacgctg     3720

gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat cgaactggat     3780

ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc aatgatgagc     3840

acttttaaag ttctgctatg tggcgcggta ttatcccgta ttgacgccgg gcaagagcaa     3900

ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc agtcacagaa     3960

aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat aaccatgagt     4020

gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga gctaaccgct     4080

tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc ggagctgaat     4140

gaagccatac caaacgacga gcgtgacacc acgatgcctg tagcaatggc aacaacgttg     4200

cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt aatagactgg     4260

atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc tggctggttt     4320

attgctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc agcactgggg     4380

ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca ggcaactatg     4440

gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca ttggtaactg     4500

tcagaccaag tttactcata tatactttag attgatttaa aacttcattt ttaatttaaa     4560

aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt     4620

tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt     4680

tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt     4740

ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag     4800

ataccaaata ctgttcttct agtgtagccg tagttaggcc accacttcaa gaactctgta     4860

gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat     4920

aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg     4980

ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg     5040

agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag aaaggcggac     5100

aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga     5160

aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt     5220

ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccttttta     5280

cggttcctgg ccttttgctg gccttttgct cacatgttct ttcctgcgtt atcccctgat     5340

tctgtggata accgtattac cgcctttgag tgagctgata ccgctcgccg cagccgaacg     5400

accgagcgca gcgagtcagt gagcgaggaa gcggaagagc gcccaatacg caaaccgcct     5460

ctccccgcgc gttggccgat tcattaatgc agctggcacg acaggtttcc cgactggaaa     5520

gcgggcagtg agcgcaacgc aattaatgtg agttagctca ctcattaggc accccaggct     5580

ttacacttta tgcttccggc tcgtatgttg tgtggaattg tgagcggata acaatttcac     5640

acaggaaaca gctatgacca tgattacgcc agatttaatt aaggccttaa ttagg          5695


<210>  126
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal amino acids of the KASH domain of Nesprin-2 (KASH2)

<400>  126

Phe Ala Arg Ser Phe Tyr Pro Met Leu Arg Tyr Thr Asn Gly Pro Pro 
1               5                   10                  15      


Pro Thr 
        


<210>  127
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal amino acids of the KASH domain of Nesprin-2 (KASH2)

<400>  127

Phe Tyr Pro Met Leu Arg Tyr Thr Asn Gly Pro Pro Pro Thr 
1               5                   10                  


<210>  128
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal amino acids of the KASH domain of Nesprin-2 (KASH2)

<400>  128

Phe Ala Arg Ser Phe Tyr Pro Met Leu Arg Tyr Thr Asn Gly 
1               5                   10                  


<210>  129
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal amino acids of the KASH domain of Nesprin-2 (KASH2)

<400>  129

Phe Ala Arg Ser Phe Tyr Pro Met Leu Arg Tyr Thr Asn Gly Pro Pro 
1               5                   10                  15      


Pro Thr Ala 
            


