                         SEQUENCE LISTING

<110>  Lipum AB
 
<120>  NOVEL BSSL ANTIBODIES

<130>  HSJ106660P.WOP

<150>  SE 1950888-6
<151>  2019-07-12

<160>  202   

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  1

Tyr Thr Glu Gly Gly Phe 
1               5       


<210>  2
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  2

Leu Glu Asn Pro Gln Pro His Pro Gly Trp Gln Gly Thr Leu 
1               5                   10                  


<210>  3
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Lys Leu Gly Ala Val Tyr Thr Glu Gly Gly Phe 
1               5                   10          


<210>  4
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  4

Asn Ile Trp Val Pro Gln Gly Arg Lys Gln Val Ser Arg Asp Leu Pro 
1               5                   10                  15      


Val Met 
        


<210>  5
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  5

Val Lys Arg Asn Ile Ala Ala 
1               5           


<210>  6
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  6

His Tyr Val Gly Phe Val Pro Val Ile Asp Gly Asp Phe 
1               5                   10              


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1

<400>  7

Gly Tyr Thr Phe Thr Ser Tyr Asn 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  8

Ile Asn Pro Gly Asp Gly Ala Thr 
1               5               


<210>  9
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR3

<400>  9

Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr 
1               5                   10          


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1

<400>  10

Pro Ser Ile Ser Tyr 
1               5   


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  11

His Gln Arg Ser Ser Ser Pro Thr 
1               5               


<210>  12
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended HCDR2

<400>  12

Met Gly Val Ile Asn Pro Gly Asp Gly Ala Thr Ser Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Lys 
        


<210>  13
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Trp Val Lys Arg Asn Ile Ala Ala 
1               5                   


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended LCDR1

<400>  14

Arg Ala Ser Pro Ser Ile Ser Tyr Met Asn 
1               5                   10  


<210>  15
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended LCDR2

<400>  15

Ala Thr Ser Ser Leu Ala 
1               5       


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended LCDR1

<400>  16

Ser Ala Ser Pro Ser Ile Ser Tyr Met Asn 
1               5                   10  


<210>  17
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended LCDR2

<400>  17

Ala Thr Ser Ser Leu Pro 
1               5       


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  18

Ile Tyr Pro Gly Asp Gly Ala Thr 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR2

<400>  19

Ile Tyr Pro Gly Asp Gly Ser Thr 
1               5               


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR1

<400>  20

Ser Ser Ile Ser Tyr 
1               5   


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  21

His Gln Arg Ser Ser Tyr Pro Thr 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCDR3

<400>  22

His Gln Arg Ser Ser Thr Pro Thr 
1               5               


<210>  23
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended HCDR2

<400>  23

Met Gly Val Ile Tyr Pro Gly Asp Gly Ala Thr Ser Tyr Ala Gln Lys 
1               5                   10                  15      


Phe Lys 
        


<210>  24
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended HCDR2

<400>  24

Met Gly Val Ile Asn Pro Gly Asp Gly Ala Thr Ser Tyr Asn Gln Lys 
1               5                   10                  15      


Phe Gln 
        


<210>  25
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended HCDR2

<400>  25

Ile Gly Val Ile Tyr Pro Gly Asp Gly Ser Thr Ser Tyr Asn Gln Lys 
1               5                   10                  15      


Phe Gln 
        


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended LCDR1

<400>  26

Ser Ala Ser Ser Ser Ile Ser Tyr Met Asn 
1               5                   10  


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended LCDR1

<400>  27

Arg Ala Ser Ser Ser Ile Ser Tyr Leu Asn 
1               5                   10  


<210>  28
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended LCDR2

<400>  28

Ala Thr Ser Lys Leu Pro 
1               5       


<210>  29
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended LCDR2

<400>  29

Ala Ala Ser Ser Leu Ala 
1               5       


<210>  30
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVCR

<400>  30

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Tyr Pro Gly Asp Gly Ala Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  31
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LVCR

<400>  31

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Pro Ser Ile Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  32
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVCR

<400>  32

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Asp Gly Ala Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  33
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCVR

<400>  33

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Ile Ser Tyr Leu 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  34
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVCR

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Pro Gly Asp Gly Ser Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  35
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCVR

<400>  35

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Lys Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Thr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  36
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVCR

<400>  36

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Asp Gly Ala Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  37
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCVR

<400>  37

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Pro Ser Ile Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  38
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCVR

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Pro Ser Ile Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Ser Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  39
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZH1

<400>  39

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  40
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZH2

<400>  40

Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
1               5                   10                  


<210>  41
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZH3

<400>  41

Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met 
1               5                   10                  15      


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  30      


<210>  42
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZH4

<400>  42

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  43
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZL1

<400>  43

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZL2

<400>  44

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  45
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZL3

<400>  45

Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
1               5                   10                  15      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
            20                  25                  30          


Cys 
    


<210>  46
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZL4

<400>  46

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  47
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  47

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Ser Asp Gly Tyr Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  48
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  48

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Ser Asp Gly Ala Thr Ser Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  49
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  49

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Ser Asp Gly Ala Thr Ser Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  50
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  50

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Asp Gly Ala Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  51
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  51

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Asp Gly Tyr Thr Ser Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  52
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  52

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Ser Asp Gly Ala Thr Ser Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  53
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  53

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Asp Gly Ala Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  54
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  54

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Ser Asp Gly Ala Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  55
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  55

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Pro Gly Asp Gly Ala Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  56
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  56

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Asp Gly Ala Thr Ser Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  57
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  57

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Ser Asp Gly Ala Thr Ser Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  58
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  58

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Gly Gly Tyr Thr Ser Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  59
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  59

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Asp Gly Ala Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  60
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  60

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Asp Gly Ala Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  61
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  61

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Asp Gly Ala Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  62
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  62

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Asp Gly Ala Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  63
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  63

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Tyr Pro Gly Gly Gly Tyr Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  64
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  64

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Ser Asp Gly Ala Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  65
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  65

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Asp Gly Ala Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  66
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  66

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Asp Gly Ala Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  67
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  67

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Ser Ser Gly Ser Thr Ser Tyr Thr Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  68
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  68

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Asp Gly Ala Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  69
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  69

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Asp Gly Ala Thr Ser Tyr Asp Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  70
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  70

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Ser Asp Gly Ala Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  71
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  71

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Asp Gly Ala Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  72
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  72

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Ser Asp Gly Ala Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  73
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  73

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Ser Asp Gly Ala Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  74
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  74

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Asp Gly Ala Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  75
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  75

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Gly Ala Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  76
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  76

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Ser Asp Gly Ala Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  77
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  77

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Asp Gly Ala Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  78
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  78

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Asp Gly Ala Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  79
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  79

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Ser Asp Gly Ala Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  80
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  80

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  81
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  81

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Pro Ser Ile Ser Tyr Leu 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Arg Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  82
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  82

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Ala Ser Arg Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Thr Ser Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  83
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  83

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Pro Ser Ile Ser Tyr Leu 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  84
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  84

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Pro Ser Ile Ser Tyr Leu 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Arg Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  85
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  85

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Tyr Leu 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Ala Ser Lys Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  86
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  86

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Ile Ser Tyr Leu 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Thr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  87
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  87

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Pro Ser Ile Ser Tyr Leu 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  88
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  88

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Ile Ser Tyr Leu 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Ala Ser Arg Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  89
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  89

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Arg Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  90
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  90

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Pro Ser Ile Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Ala Ser Ser Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  91
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  91

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Tyr Leu 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Ala Ser Arg Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Thr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  92
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  92

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Pro Ser Ile Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Thr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  93
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  93

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Pro Ser Ile Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  94
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  94

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Ser Ile Ser Tyr Leu 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Ala Ser Ser Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  95
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  95

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Ser Ile Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Thr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  96
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  96

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Tyr Leu 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  97
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  97

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Tyr Leu 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  98
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  98

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Ser Ile Ser Tyr Leu 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Ala Ser Arg Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  99
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  99

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  100
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  100

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Tyr Leu 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  101
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  101

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Pro Ser Ile Ser Tyr Leu 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Arg Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Asn Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  102
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  102

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  103
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  103

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Leu 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Ala Ser Arg Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Thr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  104
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  104

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Ser Ile Ser Tyr Leu 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Ala Ser Lys Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  105
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  105

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Pro Ser Ile Ser Tyr Leu 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Ser Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  106
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  106

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Pro Ser Ile Ser Tyr Leu 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  107
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  107

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Pro Ser Ile Ser Tyr Leu 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Arg Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  108
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  108

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Ser Ile Ser Tyr Leu 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Ala Ser Arg Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Thr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  109
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  109

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Arg Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Thr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  110
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  110

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Ala Ser Lys Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  111
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  111

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Ile Ser Tyr Leu 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Ala Ser Arg Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  112
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  112

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Pro Ser Ile Ser Tyr Leu 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  113
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  113

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Pro Ser Ile Ser Tyr Leu 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Lys Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  114
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  114

Gln Ile Val Leu Thr Gln Ser Pro Ala Val Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  115
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 LALA-PG HC

<400>  115

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  116
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIgG1 LALA-PG LC

<400>  116

Gln Ile Val Leu Thr Gln Ser Pro Ala Val Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 140                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
145                 150                 155                 160 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            180                 185                 190         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        195                 200                 205             


Arg Gly Glu Cys 
    210         


<210>  117
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIgG1 LALA-PG HC

<400>  117

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Asn Ser Gly Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Pro Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Tyr Gly Ser Ser Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  118
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIgG1 LALA-PG  LC

<400>  118

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys 
    210             


<210>  119
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIgG4 S228P HC

<400>  119

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Tyr Pro Gly Asp Gly Ala Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210>  120
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIgG4 S228P  LC

<400>  120

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Pro Ser Ile Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 140                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
145                 150                 155                 160 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            180                 185                 190         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        195                 200                 205             


Arg Gly Glu Cys 
    210         


<210>  121
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIgG4 S228P HC

<400>  121

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Asp Gly Ala Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210>  122
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIgG4 S228P  LC

<400>  122

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Ile Ser Tyr Leu 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 140                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
145                 150                 155                 160 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            180                 185                 190         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        195                 200                 205             


Arg Gly Glu Cys 
    210         


<210>  123
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIgG4 S228P HC

<400>  123

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Pro Gly Asp Gly Ser Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210>  124
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIgG4 S228P  LC

<400>  124

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Lys Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Thr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 140                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
145                 150                 155                 160 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            180                 185                 190         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        195                 200                 205             


Arg Gly Glu Cys 
    210         


<210>  125
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIgG4 S228P HC

<400>  125

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Asp Gly Ala Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210>  126
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIgG4 S228P  LC

<400>  126

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Pro Ser Ile Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 140                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
145                 150                 155                 160 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            180                 185                 190         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        195                 200                 205             


Arg Gly Glu Cys 
    210         


<210>  127
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIgG4 S228P HC

<400>  127

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Gly Asp Gly Ala Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210>  128
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIgG4 S228P  LC

<400>  128

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Pro Ser Ile Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ala Thr Ser Ser Leu Pro Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Ser Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 140                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
145                 150                 155                 160 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            180                 185                 190         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        195                 200                 205             


Arg Gly Glu Cys 
    210         


<210>  129
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIgG4 S228P HC

<400>  129

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210>  130
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIgG4 S228P  LC

<400>  130

Gln Ile Val Leu Thr Gln Ser Pro Ala Val Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 140                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
145                 150                 155                 160 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            180                 185                 190         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        195                 200                 205             


Arg Gly Glu Cys 
    210         


<210>  131
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIgG4 S228P HC

<400>  131

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210>  132
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIgG4 S228P  LC

<400>  132

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 140                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
145                 150                 155                 160 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            180                 185                 190         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        195                 200                 205             


Arg Gly Glu Cys 
    210         


<210>  133
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIgG4 S228P HC

<400>  133

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Asn Ser Gly Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Pro Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Tyr Gly Ser Ser Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  134
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIgG4 S228P  LC

<400>  134

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  135
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG HC

<400>  135

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135             


<210>  136
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG LC

<400>  136

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Leu Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Val 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Ile Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Thr Ser 
    50                  55                  60                  


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg 
            100                 105                 110         


Ser Ser Tyr Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  137
<211>  579
<212>  PRT
<213>  Mus musculus

<400>  137

Ala Lys Leu Gly Ala Val Tyr Thr Glu Gly Gly Phe Val Glu Gly Val 
1               5                   10                  15      


Asn Lys Lys Leu Ser Leu Leu Gly Gly Asp Ser Val Asp Ile Phe Lys 
            20                  25                  30          


Gly Ile Pro Phe Ala Thr Ala Lys Thr Leu Glu Asn Pro Gln Arg His 
        35                  40                  45              


Pro Gly Trp Gln Gly Thr Leu Lys Ala Thr Asn Phe Lys Lys Arg Cys 
    50                  55                  60                  


Leu Gln Ala Thr Ile Thr Gln Asp Asn Thr Tyr Gly Gln Glu Asp Cys 
65                  70                  75                  80  


Leu Tyr Leu Asn Ile Trp Val Pro Gln Gly Arg Lys Gln Val Ser His 
                85                  90                  95      


Asn Leu Pro Val Met Val Trp Ile Tyr Gly Gly Ala Phe Leu Met Gly 
            100                 105                 110         


Ser Gly Gln Gly Ala Asn Phe Leu Lys Asn Tyr Leu Tyr Asp Gly Glu 
        115                 120                 125             


Glu Ile Ala Thr Arg Gly Asn Val Ile Val Val Thr Phe Asn Tyr Arg 
    130                 135                 140                 


Val Gly Pro Leu Gly Phe Leu Ser Thr Gly Asp Ala Asn Leu Pro Gly 
145                 150                 155                 160 


Asn Phe Gly Leu Arg Asp Gln His Met Ala Ile Ala Trp Val Lys Arg 
                165                 170                 175     


Asn Ile Ala Ala Phe Gly Gly Asp Pro Asp Asn Ile Thr Ile Phe Gly 
            180                 185                 190         


Glu Ser Ala Gly Ala Ala Ser Val Ser Leu Gln Thr Leu Ser Pro Tyr 
        195                 200                 205             


Asn Lys Gly Leu Ile Arg Arg Ala Ile Ser Gln Ser Gly Met Ala Leu 
    210                 215                 220                 


Ser Pro Trp Ala Ile Gln Lys Asn Pro Leu Phe Trp Ala Lys Thr Ile 
225                 230                 235                 240 


Ala Lys Lys Val Gly Cys Pro Thr Glu Asp Thr Gly Lys Met Ala Ala 
                245                 250                 255     


Cys Leu Lys Ile Thr Asp Pro Arg Ala Leu Thr Leu Ala Tyr Lys Leu 
            260                 265                 270         


Pro Val Lys Lys Gln Glu Tyr Pro Val Val His Tyr Leu Ala Phe Ile 
        275                 280                 285             


Pro Val Ile Asp Gly Asp Phe Ile Pro Asp Asp Pro Ile Asn Leu Tyr 
    290                 295                 300                 


Asn Asn Thr Ala Asp Ile Asp Tyr Ile Ala Gly Ile Asn Asn Met Asp 
305                 310                 315                 320 


Gly His Leu Phe Ala Thr Ile Asp Val Pro Ala Val Asp Lys Thr Lys 
                325                 330                 335     


Gln Thr Val Thr Glu Glu Asp Phe Tyr Arg Leu Val Ser Gly His Thr 
            340                 345                 350         


Val Ala Lys Gly Leu Lys Gly Ala Gln Ala Thr Phe Asp Ile Tyr Thr 
        355                 360                 365             


Glu Ser Trp Ala Gln Asp Pro Ser Gln Glu Asn Met Lys Lys Thr Val 
    370                 375                 380                 


Val Ala Phe Glu Thr Asp Val Leu Phe Leu Ile Pro Thr Glu Ile Ala 
385                 390                 395                 400 


Leu Ala Gln His Lys Ala His Ala Lys Ser Ala Lys Thr Tyr Ser Tyr 
                405                 410                 415     


Leu Phe Ser His Pro Ser Arg Met Pro Ile Tyr Pro Lys Trp Met Gly 
            420                 425                 430         


Ala Asp His Ala Asp Asp Leu Gln Tyr Val Phe Gly Lys Pro Phe Ala 
        435                 440                 445             


Thr Pro Leu Gly Tyr Arg Pro Gln Asp Arg Ala Val Ser Lys Ala Met 
    450                 455                 460                 


Ile Ala Tyr Trp Thr Asn Phe Ala Arg Ser Gly Asp Pro Asn Met Gly 
465                 470                 475                 480 


Asn Ser Pro Val Pro Thr His Trp Tyr Pro Tyr Thr Leu Glu Asn Gly 
                485                 490                 495     


Asn Tyr Leu Asp Ile Thr Lys Thr Ile Thr Ser Ala Ser Met Lys Glu 
            500                 505                 510         


His Leu Arg Glu Lys Phe Leu Lys Phe Trp Ala Val Thr Phe Glu Val 
        515                 520                 525             


Leu Pro Thr Val Thr Gly Asp Gln Asp Thr Leu Thr Pro Pro Glu Asp 
    530                 535                 540                 


Asp Ser Glu Val Ala Pro Asp Pro Pro Ser Asp Asp Ser Gln Val Val 
545                 550                 555                 560 


Pro Val Pro Pro Thr Asp Asp Ser Val Glu Ala Gln Met Pro Ala Thr 
                565                 570                 575     


Ile Gly Phe 
            


<210>  138
<211>  722
<212>  PRT
<213>  Homo sapiens

<400>  138

Ala Lys Leu Gly Ala Val Tyr Thr Glu Gly Gly Phe Val Glu Gly Val 
1               5                   10                  15      


Asn Lys Lys Leu Gly Leu Leu Gly Asp Ser Val Asp Ile Phe Lys Gly 
            20                  25                  30          


Ile Pro Phe Ala Ala Pro Thr Lys Ala Leu Glu Asn Pro Gln Pro His 
        35                  40                  45              


Pro Gly Trp Gln Gly Thr Leu Lys Ala Lys Asn Phe Lys Lys Arg Cys 
    50                  55                  60                  


Leu Gln Ala Thr Ile Thr Gln Asp Ser Thr Tyr Gly Asp Glu Asp Cys 
65                  70                  75                  80  


Leu Tyr Leu Asn Ile Trp Val Pro Gln Gly Arg Lys Gln Val Ser Arg 
                85                  90                  95      


Asp Leu Pro Val Met Ile Trp Ile Tyr Gly Gly Ala Phe Leu Met Gly 
            100                 105                 110         


Ser Gly His Gly Ala Asn Phe Leu Asn Asn Tyr Leu Tyr Asp Gly Glu 
        115                 120                 125             


Glu Ile Ala Thr Arg Gly Asn Val Ile Val Val Thr Phe Asn Tyr Arg 
    130                 135                 140                 


Val Gly Pro Leu Gly Phe Leu Ser Thr Gly Asp Ala Asn Leu Pro Gly 
145                 150                 155                 160 


Asn Tyr Gly Leu Arg Asp Gln His Met Ala Ile Ala Trp Val Lys Arg 
                165                 170                 175     


Asn Ile Ala Ala Phe Gly Gly Asp Pro Asn Asn Ile Thr Leu Phe Gly 
            180                 185                 190         


Glu Ser Ala Gly Gly Ala Ser Val Ser Leu Gln Thr Leu Ser Pro Tyr 
        195                 200                 205             


Asn Lys Gly Leu Ile Arg Arg Ala Ile Ser Gln Ser Gly Val Ala Leu 
    210                 215                 220                 


Ser Pro Trp Val Ile Gln Lys Asn Pro Leu Phe Trp Ala Lys Lys Val 
225                 230                 235                 240 


Ala Glu Lys Val Gly Cys Pro Val Gly Asp Ala Ala Arg Met Ala Gln 
                245                 250                 255     


Cys Leu Lys Val Thr Asp Pro Arg Ala Leu Thr Leu Ala Tyr Lys Val 
            260                 265                 270         


Pro Leu Ala Gly Leu Glu Tyr Pro Met Leu His Tyr Val Gly Phe Val 
        275                 280                 285             


Pro Val Ile Asp Gly Asp Phe Ile Pro Ala Asp Pro Ile Asn Leu Tyr 
    290                 295                 300                 


Ala Asn Ala Ala Asp Ile Asp Tyr Ile Ala Gly Thr Asn Asn Met Asp 
305                 310                 315                 320 


Gly His Ile Phe Ala Ser Ile Asp Met Pro Ala Ile Asn Lys Gly Asn 
                325                 330                 335     


Lys Lys Val Thr Glu Glu Asp Phe Tyr Lys Leu Val Ser Glu Phe Thr 
            340                 345                 350         


Ile Thr Lys Gly Leu Arg Gly Ala Lys Thr Thr Phe Asp Val Tyr Thr 
        355                 360                 365             


Glu Ser Trp Ala Gln Asp Pro Ser Gln Glu Asn Lys Lys Lys Thr Val 
    370                 375                 380                 


Val Asp Phe Glu Thr Asp Val Leu Phe Leu Val Pro Thr Glu Ile Ala 
385                 390                 395                 400 


Leu Ala Gln His Arg Ala Asn Ala Lys Ser Ala Lys Thr Tyr Ala Tyr 
                405                 410                 415     


Leu Phe Ser His Pro Ser Arg Met Pro Val Tyr Pro Lys Trp Val Gly 
            420                 425                 430         


Ala Asp His Ala Asp Asp Ile Gln Tyr Val Phe Gly Lys Pro Phe Ala 
        435                 440                 445             


Thr Pro Thr Gly Tyr Arg Pro Gln Asp Arg Thr Val Ser Lys Ala Met 
    450                 455                 460                 


Ile Ala Tyr Trp Thr Asn Phe Ala Lys Thr Gly Asp Pro Asn Met Gly 
465                 470                 475                 480 


Asp Ser Ala Val Pro Thr His Trp Glu Pro Tyr Thr Thr Glu Asn Ser 
                485                 490                 495     


Gly Tyr Leu Glu Ile Thr Lys Lys Met Gly Ser Ser Ser Met Lys Arg 
            500                 505                 510         


Ser Leu Arg Thr Asn Phe Leu Arg Tyr Trp Thr Leu Thr Tyr Leu Ala 
        515                 520                 525             


Leu Pro Thr Val Thr Asp Gln Glu Ala Thr Pro Val Pro Pro Thr Gly 
    530                 535                 540                 


Asp Ser Glu Ala Thr Pro Val Pro Pro Thr Gly Asp Ser Glu Thr Ala 
545                 550                 555                 560 


Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr 
                565                 570                 575     


Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala 
            580                 585                 590         


Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro 
        595                 600                 605             


Thr Gly Asp Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly 
    610                 615                 620                 


Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val Pro 
625                 630                 635                 640 


Pro Thr Gly Asp Ala Gly Pro Pro Pro Val Pro Pro Thr Gly Asp Ser 
                645                 650                 655     


Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Gly Ala Pro Pro Val 
            660                 665                 670         


Thr Pro Thr Gly Asp Ser Glu Thr Ala Pro Val Pro Pro Thr Gly Asp 
        675                 680                 685             


Ser Gly Ala Pro Pro Val Pro Pro Thr Gly Asp Ser Glu Ala Ala Pro 
    690                 695                 700                 


Val Pro Pro Thr Asp Asp Ser Lys Glu Ala Gln Met Pro Ala Val Ile 
705                 710                 715                 720 


Arg Phe 
        


<210>  139
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 HC

<400>  139

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210>  140
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 LC

<400>  140

Gln Ile Val Leu Thr Gln Ser Pro Ala Val Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 140                 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
145                 150                 155                 160 


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
            180                 185                 190         


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
        195                 200                 205             


Arg Gly Glu Cys 
    210         


<210>  141
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended HCDR2

<400>  141

Ile Gly Val Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys 
1               5                   10                  15      


Phe Lys 
        


<210>  142
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended LCDR1

<400>  142

Ser Ala Ser Ser Ser Ile Ser Tyr Met His 
1               5                   10  


<210>  143
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extended LCDR2

<400>  143

Asp Thr Ser Lys Leu Ala 
1               5       


<210>  144
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCVR

<400>  144

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Tyr Gly Ser Ser Pro Leu Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  145
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LCVR

<400>  145

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Ser Tyr Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  146
<211>  537
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  t-hBSSL

<400>  146

Ala Lys Leu Gly Ala Val Tyr Thr Glu Gly Gly Phe Val Glu Gly Val 
1               5                   10                  15      


Asn Lys Lys Leu Gly Leu Leu Gly Asp Ser Val Asp Ile Phe Lys Gly 
            20                  25                  30          


Ile Pro Phe Ala Ala Pro Thr Lys Ala Leu Glu Asn Pro Gln Pro His 
        35                  40                  45              


Pro Gly Trp Gln Gly Thr Leu Lys Ala Lys Asn Phe Lys Lys Arg Cys 
    50                  55                  60                  


Leu Gln Ala Thr Ile Thr Gln Asp Ser Thr Tyr Gly Asp Glu Asp Cys 
65                  70                  75                  80  


Leu Tyr Leu Asn Ile Trp Val Pro Gln Gly Arg Lys Gln Val Ser Arg 
                85                  90                  95      


Asp Leu Pro Val Met Ile Trp Ile Tyr Gly Gly Ala Phe Leu Met Gly 
            100                 105                 110         


Ser Gly His Gly Ala Asn Phe Leu Asn Asn Tyr Leu Tyr Asp Gly Glu 
        115                 120                 125             


Glu Ile Ala Thr Arg Gly Asn Val Ile Val Val Thr Phe Asn Tyr Arg 
    130                 135                 140                 


Val Gly Pro Leu Gly Phe Leu Ser Thr Gly Asp Ala Asn Leu Pro Gly 
145                 150                 155                 160 


Asn Tyr Gly Leu Arg Asp Gln His Met Ala Ile Ala Trp Val Lys Arg 
                165                 170                 175     


Asn Ile Ala Ala Phe Gly Gly Asp Pro Asn Asn Ile Thr Leu Phe Gly 
            180                 185                 190         


Glu Ser Ala Gly Gly Ala Ser Val Ser Leu Gln Thr Leu Ser Pro Tyr 
        195                 200                 205             


Asn Lys Gly Leu Ile Arg Arg Ala Ile Ser Gln Ser Gly Val Ala Leu 
    210                 215                 220                 


Ser Pro Trp Val Ile Gln Lys Asn Pro Leu Phe Trp Ala Lys Lys Val 
225                 230                 235                 240 


Ala Glu Lys Val Gly Cys Pro Val Gly Asp Ala Ala Arg Met Ala Gln 
                245                 250                 255     


Cys Leu Lys Val Thr Asp Pro Arg Ala Leu Thr Leu Ala Tyr Lys Val 
            260                 265                 270         


Pro Leu Ala Gly Leu Glu Tyr Pro Met Leu His Tyr Val Gly Phe Val 
        275                 280                 285             


Pro Val Ile Asp Gly Asp Phe Ile Pro Ala Asp Pro Ile Asn Leu Tyr 
    290                 295                 300                 


Ala Asn Ala Ala Asp Ile Asp Tyr Ile Ala Gly Thr Asn Asn Met Asp 
305                 310                 315                 320 


Gly His Ile Phe Ala Ser Ile Asp Met Pro Ala Ile Asn Lys Gly Asn 
                325                 330                 335     


Lys Lys Val Thr Glu Glu Asp Phe Tyr Lys Leu Val Ser Glu Phe Thr 
            340                 345                 350         


Ile Thr Lys Gly Leu Arg Gly Ala Lys Thr Thr Phe Asp Val Tyr Thr 
        355                 360                 365             


Glu Ser Trp Ala Gln Asp Pro Ser Gln Glu Asn Lys Lys Lys Thr Val 
    370                 375                 380                 


Val Asp Phe Glu Thr Asp Val Leu Phe Leu Val Pro Thr Glu Ile Ala 
385                 390                 395                 400 


Leu Ala Gln His Arg Ala Asn Ala Lys Ser Ala Lys Thr Tyr Ala Tyr 
                405                 410                 415     


Leu Phe Ser His Pro Ser Arg Met Pro Val Tyr Pro Lys Trp Val Gly 
            420                 425                 430         


Ala Asp His Ala Asp Asp Ile Gln Tyr Val Phe Gly Lys Pro Phe Ala 
        435                 440                 445             


Thr Pro Thr Gly Tyr Arg Pro Gln Asp Arg Thr Val Ser Lys Ala Met 
    450                 455                 460                 


Ile Ala Tyr Trp Thr Asn Phe Ala Lys Thr Gly Asp Pro Asn Met Gly 
465                 470                 475                 480 


Asp Ser Ala Val Pro Thr His Trp Glu Pro Tyr Thr Thr Glu Asn Ser 
                485                 490                 495     


Gly Tyr Leu Glu Ile Thr Lys Lys Met Gly Ser Ser Ser Met Lys Arg 
            500                 505                 510         


Ser Leu Arg Thr Asn Phe Leu Arg Tyr Trp Thr Leu Thr Tyr Leu Ala 
        515                 520                 525             


Leu Pro Ala His His His His His His 
    530                 535         


<210>  147
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  147

Tyr Thr Glu Gly Gly 
1               5   


<210>  148
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  148

Ala Lys Leu Gly Ala Val Tyr 
1               5           


<210>  149
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  149

Ala Lys Leu Gly Ala Val Tyr Thr Glu Gly Gly 
1               5                   10      


<210>  150
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  150

Ala Lys Leu Gly Ala Val Tyr Thr Glu Gly Gly Phe Val Glu Gly Val 
1               5                   10                  15      


Asn Lys Lys Leu Gly Leu Leu Gly Asp 
            20                  25  


<210>  151
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  151

Ala Lys Leu Gly Ala Val Tyr Thr Glu Gly Gly Phe Val Glu Gly Val 
1               5                   10                  15      


Asn Lys Lys Leu Gly Leu Leu Gly Asp Ser 
            20                  25      


<210>  152
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  152

Ala Lys Leu Gly Ala Val Tyr Thr Glu Gly Gly Phe Val Glu Gly Val 
1               5                   10                  15      


Asn Lys Lys Leu Gly Leu Leu Gly Asp Ser Val Asp 
            20                  25              


<210>  153
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iTope residues

<400>  153

Val Lys Pro Gly Ala Ser Val Lys Met 
1               5                   


<210>  154
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iTope residues

<400>  154

Tyr Asn Met His Trp Val Arg Gln Ala 
1               5                   


<210>  155
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iTope residues

<400>  155

Tyr Ala Gln Lys Phe Lys Gly Arg Val 
1               5                   


<210>  156
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iTope residues

<400>  156

Trp Gly Gln Gly Thr Thr Leu Thr Val 
1               5                   


<210>  157
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iTope residues

<400>  157

Val Thr Met Thr Cys Ser Ala Ser Ser 
1               5                   


<210>  158
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iTope residues

<400>  158

Val Thr Ile Thr Cys Arg Ala Ser Ser 
1               5                   


<210>  159
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iTope residues

<400>  159

Val Thr Ile Thr Cys Ser Ala Ser Ser 
1               5                   


<210>  160
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iTope residues

<400>  160

Leu Leu Ile Tyr Ala Thr Ser Lys Leu 
1               5                   


<210>  161
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iTope residues

<400>  161

Ile Tyr Ala Thr Ser Ser Leu Ala Ser 
1               5                   


<210>  162
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iTope residues

<400>  162

Ile Tyr Ala Ala Ser Ser Leu Ala Ser 
1               5                   


<210>  163
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  iTope residues

<400>  163

Phe Gly Gly Gly Thr Lys Leu Glu Ile 
1               5                   


<210>  164
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  164
gatacacctt caccagctac watatgcact gggtgcg                                37


<210>  165
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  165

Gly Ala Cys Ala Ala Gly Gly Gly Cys Thr Thr Gly Ala Gly Thr Gly 
1               5                   10                  15      


Gly Ala Thr Arg Gly Gly Ala Arg Thr Ala Ala Thr Cys Trp Ala Cys 
            20                  25                  30          


Cys Cys Thr Arg Gly Thr Arg Arg Thr Gly Gly Thr Lys Met Cys Ala 
        35                  40                  45              


Cys Ala Ala Gly Cys Thr Ala Cys Arg Met Thr Cys Ala Gly Ala Ala 
    50                  55                  60                  


Gly Thr Thr Cys Met Ala Gly Gly Gly Cys Cys Gly Cys Gly Thr Cys 
65                  70                  75                  80  


Ala Cys Cys 
            


<210>  166
<211>  62
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  166
cgtcaccatc acctgcagkg caagtymgag cattagctat wtgmattggt atcagcagaa       60

ac                                                                      62


<210>  167
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  167
cctaagctcc tgatctatgm trcatccars ttgsmaagtg gggtcccatc ac               52


<210>  168
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  168
gattttgcaa cttattactg tcascagagk tmtagtwmty hcacttttgg ccagggg          57


<210>  169
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVCR part 2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=I or M

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X=N or Y

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X=A or S

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X=A or N

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X=K or Q

<400>  169

Xaa Gly Val Ile Xaa Pro Gly Asp Gly Xaa Thr Ser Tyr Xaa Gln Lys 
1               5                   10                  15      


Phe Xaa 
        


<210>  170
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LVCR part 1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=S or R

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X=S or P

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X=M or L

<400>  170

Xaa Ala Ser Xaa Ser Ile Ser Tyr Xaa Asn 
1               5                   10  


<210>  171
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LVCR part 2


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X=A or T

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X=K or S

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X=A or P

<400>  171

Ala Xaa Ser Xaa Leu Xaa 
1               5       


<210>  172
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LVCR part 3


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X=S, T or Y

<400>  172

His Gln Arg Ser Ser Xaa Pro Thr 
1               5               


<210>  173
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  173

Gln Gln Ser Tyr Ser Thr Pro Thr 
1               5               


<210>  174
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC

<400>  174
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctacaata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggagta atctaccctg gtgatggtgc cacaagctac      180

gctcagaagt tcaagggccg cgtcaccatg acccgcgaca cgtccacgag cacagtctac      240

atggagctga gcagcctgcg ctctgaggac acggctgtgt attactgtgc gagagattac      300

tacggtagta gcccccttgg ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210>  175
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC

<400>  175
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc       60

atcacctgca gtgcaagtcc gagcattagc tatatgaatt ggtatcagca gaaaccaggg      120

aaagccccta agctcctgat ctatgctaca tccagcttgg caagtggggt cccatcacgt      180

ttcagtggca gtggaagcgg gacagatttc actctcacca tcagcagtct gcaacctgaa      240

gattttgcaa cttattactg tcaccagagg tctagttatc ccacttttgg ccaggggacc      300

aagctggaga tcaaa                                                       315


<210>  176
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC

<400>  176
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctacaata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggagta atcaaccctg gtgatggtgc cacaagctac      180

aatcagaagt tccagggccg cgtcaccatg acccgcgaca cgtccacgag cacagtctac      240

atggagctga gcagcctgcg ctctgaggac acggctgtgt attactgtgc gagagattac      300

tacggtagta gcccccttgg ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210>  177
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC

<400>  177
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc       60

atcacctgca gggcaagttc gagcattagc tatttgaatt ggtatcagca gaaaccaggg      120

aaagccccta agctcctgat ctatgctgca tccagcttgg caagtggggt cccatcacgt      180

ttcagtggca gtggaagcgg gacagatttc actctcacca tcagcagtct gcaacctgaa      240

gattttgcaa cttattactg tcaccagagg tctagttctc ccacttttgg ccaggggacc      300

aagctggaga tcaaa                                                       315


<210>  178
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC

<400>  178
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctacaata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gataggagta atctaccctg gtgatggttc cacaagctac      180

aatcagaagt tccagggccg cgtcaccatg acccgcgaca cgtccacgag cacagtctac      240

atggagctga gcagcctgcg ctctgaggac acggctgtgt attactgtgc gagagattac      300

tacggtagta gcccccttgg ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210>  179
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC

<400>  179
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc       60

atcacctgca gtgcaagttc gagcattagc tatatgaatt ggtatcagca gaaaccaggg      120

aaagccccta agctcctgat ctatgctaca tccaagttgc caagtggggt cccatcacgt      180

ttcagtggca gtggaagcgg gacagatttc actctcacca tcagcagtct gcaacctgaa      240

gattttgcaa cttattactg tcaccagagg tctagtactc ccacttttgg ccaggggacc      300

aagctggaga tcaaa                                                       315


<210>  180
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC

<400>  180
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctacaata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggagta atcaaccctg gtgatggtgc cacaagctac      180

gctcagaagt tcaagggccg cgtcaccatg acccgcgaca cgtccacgag cacagtctac      240

atggagctga gcagcctgcg ctctgaggac acggctgtgt attactgtgc gagagattac      300

tacggtagta gcccccttgg ctactggggc caaggaaccc tggtcaccgt ctcctca         357


<210>  181
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC

<400>  181
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc       60

atcacctgca gggcaagtcc gagcattagc tatatgaatt ggtatcagca gaaaccaggg      120

aaagccccta agctcctgat ctatgctaca tccagcttgg caagtggggt cccatcacgt      180

ttcagtggca gtggaagcgg gacagatttc actctcacca tcagcagtct gcaacctgaa      240

gattttgcaa cttattactg tcaccagagg tctagttctc ccacttttgg ccaggggacc      300

aagctggaga tcaaa                                                       315


<210>  182
<211>  315
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC

<400>  182
gacatccaga tgacccagtc tccatcctcc ctgagcgcat ctgtaggaga ccgcgtcacc       60

atcacctgca gtgcaagtcc gagcattagc tatatgaatt ggtatcagca gaaaccaggg      120

aaagccccta agctcctgat ctatgctaca tccagcttgc caagtggggt cccatcacgt      180

ttcagtggca gtggaagcgg gacagatttc actctcacca tcagcagtct gcaacctgaa      240

gattttgcaa cttattactg tcaccagagg tctagttctc ccacttttgg ccaggggacc      300

aagctggaga tcaaa                                                       315


<210>  183
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC

<400>  183
caagttcagc tgcagcagcc cggtgccgag ctggtgaaac ccggtgcctc tgtgaagatg       60

agctgcaagg ccagcggcta cacctttacc agctacaaca tgcactgggt gaagcagaca      120

cccggacaag gtttagagtg gatcggcgtg atctaccccg gcaacggcga cacctcttac      180

aaccagaagt tcaagggcaa ggccacactg accgccgaca agagcagcag caccgcctac      240

atgcagctga gctctttaac cagcgaggac tccgccgtgt actactgcgc tcgtgattac      300

tacggcagca gccctttagg ctattgggga caaggtacca ctttaaccgt ctcgagcgcc      360

tcaaccaaag gaccctccgt gtttcccctc gccccctgtt cccgctccac atccgagtca      420

accgcggcgc tgggctgcct cgtgaaggac tacttccctg agcccgtcac tgtgtcgtgg      480

aactccgggg ccctgacctc cggcgtgcac accttccctg ccgtgcttca atcctccgga      540

ctgtactccc tgtcctcggt ggtcaccgtg ccgtcgagct cgttgggaac caagacttac      600

acttgcaacg tggaccacaa gccaagcaac accaaagtgg acaagagagt cgaatctaag      660

tacggaccgc cctgcccgcc ttgccccgcc cctgagtttc tcggcggtcc tagcgtgttc      720

ctgttcccac ccaagcccaa ggacactctg atgatctccc ggacccctga agtgacctgt      780

gtggtcgtgg acgtgtcgca ggaagatccg gaggtccagt tcaattggta cgtggatggg      840

gtggaggtcc acaacgccaa gacgaagccg agagaagaac agttcaactc aacttaccgg      900

gtggtgtccg tgctgaccgt gctgcatcag gattggctca acggaaagga gtacaagtgc      960

aaagtgtcca acaagggcct gcctagctca atcgaaaaga ccatttccaa ggccaagggc     1020

cagccgaggg aaccacaggt ctatactctg ccaccgagcc aagaagagat gaccaagaac     1080

caagtgtccc tgacttgcct ggtcaagggg ttctacccgt cggacatcgc agtggagtgg     1140

gagagcaacg gacagcctga aaacaattac aagaccaccc cgcccgtgct ggatagcgac     1200

ggttccttct tcctttactc gcgcctcacc gtcgacaaga gccggtggca ggagggcaac     1260

gtgttctcct gctccgtgat gcacgaagct ctgcataacc actacactca gaagtccttg     1320

tcgctgagcc tcggaaag                                                   1338


<210>  184
<211>  636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC

<400>  184
cagatcgtgc tgacccagag ccccgctgtg atgagcgcct ctcccggtga gaaggtgacc       60

atgacttgta gcgccagcag cagcatcagc tacatgcact ggtaccagca gaagcccggc      120

accagcccta agaggtggat ctacgacacc agcaagctgg ccagcggcgt gcccgctagg      180

ttcagcggaa gcggcagcgg caccagctac tctttaacca tcagcagcat ggaggccgag      240

gatgccgcca cctactactg ccaccagaga agcagctacc ccaccttcgg cggcggcacc      300

aagctcgaga tcaagagaac tgtggccgcg ccgtcagtgt ttatcttccc tccatcggat      360

gaacagctta agtccggcac ggcgtctgtg gtctgcctgc tcaataactt ttaccctagg      420

gaagctaaag tccaatggaa agtggataac gccctgcagt caggaaacag ccaggaatcg      480

gttaccgaac aggacagcaa ggacagcact tactccttgt cgtcgactct tactctgagc      540

aaggccgatt acgagaagca caaggtctac gcctgcgagg tcacccatca gggactctcg      600

tccccggtga ccaaatcctt caatagaggc gaatgc                                636


<210>  185
<211>  1340
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC

<400>  185
ctcaagttca gctcgtgcag agcggtgctg aagtgaagaa gcccggtgcc tctgtgaagg       60

tgagctgcaa ggccagcggc tacaccttca ccagctacaa catgcactgg gtgagacaag      120

ctcccggtca aggtttagag tggatgggcg tgatctaccc cggtgatggt gctaccagct      180

acgcccagaa gttcaagggt cgtgtgacca tgaccagaga caccagcacc agcaccgtgt      240

acatggagct gagctcttta aggagcgagg acaccgccgt gtactactgc gctcgtgact      300

actacggcag cagcccttta ggctattggg gacaaggtac tttagtgacc gtctcgagcg      360

cctcaaccaa aggaccctcc gtgtttcccc tcgccccctg ttcccgctcc acatccgagt      420

caaccgcggc gctgggctgc ctcgtgaagg actacttccc tgagcccgtc actgtgtcgt      480

ggaactccgg ggccctgacc tccggcgtgc acaccttccc tgccgtgctt caatcctccg      540

gactgtactc cctgtcctcg gtggtcaccg tgccgtcgag ctcgttggga accaagactt      600

acacttgcaa cgtggaccac aagccaagca acaccaaagt ggacaagaga gtcgaatcta      660

agtacggacc gccctgcccg ccttgccccg cccctgagtt tctcggcggt cctagcgtgt      720

tcctgttccc acccaagccc aaggacactc tgatgatctc ccggacccct gaagtgacct      780

gtgtggtcgt ggacgtgtcg caggaagatc cggaggtcca gttcaattgg tacgtggatg      840

gggtggaggt ccacaacgcc aagacgaagc cgagagaaga acagttcaac tcaacttacc      900

gggtggtgtc cgtgctgacc gtgctgcatc aggattggct caacggaaag gagtacaagt      960

gcaaagtgtc caacaagggc ctgcctagct caatcgaaaa gaccatttcc aaggccaagg     1020

gccagccgag ggaaccacag gtctatactc tgccaccgag ccaagaagag atgaccaaga     1080

accaagtgtc cctgacttgc ctggtcaagg ggttctaccc gtcggacatc gcagtggagt     1140

gggagagcaa cggacagcct gaaaacaatt acaagaccac cccgcccgtg ctggatagcg     1200

acggttcctt cttcctttac tcgcgcctca ccgtcgacaa gagccggtgg caggagggca     1260

acgtgttctc ctgctccgtg atgcacgaag ctctgcataa ccactacact cagaagtcct     1320

tgtcgctgag cctcggaaag                                                 1340


<210>  186
<211>  636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC

<400>  186
gacatccaga tgacccagag ccctagctct ttaagcgcct ctgtgggcga tcgtgtgacc       60

atcacttgta gcgccagccc cagcatcagc tacatgaact ggtaccagca gaagcccggc      120

aaggccccca agctgctgat ctacgccaca agctctttag ccagcggcgt gcctagcaga      180

tttagcggca gcggtagcgg cacagacttc actttaacca tcagctcttt acagccagaa      240

gacttcgcca cctactactg ccaccagagg agcagctacc ccaccttcgg ccaaggtacc      300

aagctcgaga tcaagagaac tgtggccgcg ccgtcagtgt ttatcttccc tccatcggat      360

gaacagctta agtccggcac ggcgtctgtg gtctgcctgc tcaataactt ttaccctagg      420

gaagctaaag tccaatggaa agtggataac gccctgcagt caggaaacag ccaggaatcg      480

gttaccgaac aggacagcaa ggacagcact tactccttgt cgtcgactct tactctgagc      540

aaggccgatt acgagaagca caaggtctac gcctgcgagg tcacccatca gggactctcg      600

tccccggtga ccaaatcctt caatagaggc gaatgc                                636


<210>  187
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC

<400>  187
caagttcagc tcgtgcagag cggtgctgaa gtgaagaagc ccggtgcctc tgtgaaggtg       60

agctgcaagg ccagcggcta caccttcacc agctacaaca tgcactgggt gagacaagct      120

cccggtcaag gtttagagtg gatgggcgtg atcaaccccg gtgatggtgc taccagctac      180

aaccagaagt tccagggtcg tgtgaccatg accagagaca ccagcaccag caccgtgtac      240

atggagctga gctctttaag gagcgaggac accgccgtgt actactgcgc tcgtgactac      300

tacggcagca gccctttagg ctattgggga caaggtactt tagtgaccgt ctcgagcgcc      360

tcaaccaaag gaccctccgt gtttcccctc gccccctgtt cccgctccac atccgagtca      420

accgcggcgc tgggctgcct cgtgaaggac tacttccctg agcccgtcac tgtgtcgtgg      480

aactccgggg ccctgacctc cggcgtgcac accttccctg ccgtgcttca atcctccgga      540

ctgtactccc tgtcctcggt ggtcaccgtg ccgtcgagct cgttgggaac caagacttac      600

acttgcaacg tggaccacaa gccaagcaac accaaagtgg acaagagagt cgaatctaag      660

tacggaccgc cctgcccgcc ttgccccgcc cctgagtttc tcggcggtcc tagcgtgttc      720

ctgttcccac ccaagcccaa ggacactctg atgatctccc ggacccctga agtgacctgt      780

gtggtcgtgg acgtgtcgca ggaagatccg gaggtccagt tcaattggta cgtggatggg      840

gtggaggtcc acaacgccaa gacgaagccg agagaagaac agttcaactc aacttaccgg      900

gtggtgtccg tgctgaccgt gctgcatcag gattggctca acggaaagga gtacaagtgc      960

aaagtgtcca acaagggcct gcctagctca atcgaaaaga ccatttccaa ggccaagggc     1020

cagccgaggg aaccacaggt ctatactctg ccaccgagcc aagaagagat gaccaagaac     1080

caagtgtccc tgacttgcct ggtcaagggg ttctacccgt cggacatcgc agtggagtgg     1140

gagagcaacg gacagcctga aaacaattac aagaccaccc cgcccgtgct ggatagcgac     1200

ggttccttct tcctttactc gcgcctcacc gtcgacaaga gccggtggca ggagggcaac     1260

gtgttctcct gctccgtgat gcacgaagct ctgcataacc actacactca gaagtccttg     1320

tcgctgagcc tcggaaag                                                   1338


<210>  188
<211>  636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC

<400>  188
gacatccaga tgacccagag ccctagctct ttaagcgcct ctgtgggcga tcgtgtgacc       60

atcacttgtc gtgccagcag cagcatcagc tatttaaact ggtaccagca gaagcccggc      120

aaggccccca agctgctgat ctacgccgcc tcttctttag cctctggcgt gccttctcgt      180

ttcagcggaa gcggcagcgg caccgacttc actttaacca tcagctcttt acagccagaa      240

gacttcgcca cctactactg ccaccagagg agcagcagcc ccaccttcgg acaaggtacc      300

aagctcgaga tcaagagaac tgtggccgcg ccgtcagtgt ttatcttccc tccatcggat      360

gaacagctta agtccggcac ggcgtctgtg gtctgcctgc tcaataactt ttaccctagg      420

gaagctaaag tccaatggaa agtggataac gccctgcagt caggaaacag ccaggaatcg      480

gttaccgaac aggacagcaa ggacagcact tactccttgt cgtcgactct tactctgagc      540

aaggccgatt acgagaagca caaggtctac gcctgcgagg tcacccatca gggactctcg      600

tccccggtga ccaaatcctt caatagaggc gaatgc                                636


<210>  189
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC

<400>  189
caagttcagc tggtgcagag cggagccgag gtgaaaaagc ccggtgcctc tgtgaaggtg       60

agctgcaagg ccagcggcta cacctttacc agctacaaca tgcactgggt gaggcaagct      120

cccggtcaag gtctggagtg gatcggcgtg atctaccccg gcgacggcag cacctcttac      180

aaccagaagt tccaaggtcg tgtgaccatg actcgtgaca ccagcaccag caccgtgtac      240

atggagctga gctctttaag gagcgaggat accgccgtgt actactgcgc tcgtgactac      300

tacggcagca gccctctggg ctattggggc caaggtactt tagtgaccgt ctcgagcgcc      360

tcaaccaaag gaccctccgt gtttcccctc gccccctgtt cccgctccac atccgagtca      420

accgcggcgc tgggctgcct cgtgaaggac tacttccctg agcccgtcac tgtgtcgtgg      480

aactccgggg ccctgacctc cggcgtgcac accttccctg ccgtgcttca atcctccgga      540

ctgtactccc tgtcctcggt ggtcaccgtg ccgtcgagct cgttgggaac caagacttac      600

acttgcaacg tggaccacaa gccaagcaac accaaagtgg acaagagagt cgaatctaag      660

tacggaccgc cctgcccgcc ttgccccgcc cctgagtttc tcggcggtcc tagcgtgttc      720

ctgttcccac ccaagcccaa ggacactctg atgatctccc ggacccctga agtgacctgt      780

gtggtcgtgg acgtgtcgca ggaagatccg gaggtccagt tcaattggta cgtggatggg      840

gtggaggtcc acaacgccaa gacgaagccg agagaagaac agttcaactc aacttaccgg      900

gtggtgtccg tgctgaccgt gctgcatcag gattggctca acggaaagga gtacaagtgc      960

aaagtgtcca acaagggcct gcctagctca atcgaaaaga ccatttccaa ggccaagggc     1020

cagccgaggg aaccacaggt ctatactctg ccaccgagcc aagaagagat gaccaagaac     1080

caagtgtccc tgacttgcct ggtcaagggg ttctacccgt cggacatcgc agtggagtgg     1140

gagagcaacg gacagcctga aaacaattac aagaccaccc cgcccgtgct ggatagcgac     1200

ggttccttct tcctttactc gcgcctcacc gtcgacaaga gccggtggca ggagggcaac     1260

gtgttctcct gctccgtgat gcacgaagct ctgcataacc actacactca gaagtccttg     1320

tcgctgagcc tcggaaag                                                   1338


<210>  190
<211>  636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC

<400>  190
gacatccaga tgacccagag ccctagctct ttaagcgcct ctgtgggcga tcgtgtgacc       60

atcacttgta gcgccagcag cagcatcagc tacatgaact ggtaccagca gaagcccggc      120

aaggccccca agctgctgat ctacgccacc agcaagctgc ctagcggcgt gccctccaga      180

ttttctggca gcggctctgg caccgacttt actttaacca tcagctcttt acagccagaa      240

gacttcgcca cctactactg ccaccagagg agcagcaccc ctaccttcgg ccaaggtacc      300

aagctcgaga tcaagagaac tgtggccgcg ccgtcagtgt ttatcttccc tccatcggat      360

gaacagctta agtccggcac ggcgtctgtg gtctgcctgc tcaataactt ttaccctagg      420

gaagctaaag tccaatggaa agtggataac gccctgcagt caggaaacag ccaggaatcg      480

gttaccgaac aggacagcaa ggacagcact tactccttgt cgtcgactct tactctgagc      540

aaggccgatt acgagaagca caaggtctac gcctgcgagg tcacccatca gggactctcg      600

tccccggtga ccaaatcctt caatagaggc gaatgc                                636


<210>  191
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC

<400>  191
caagttcagc tcgtgcagag cggtgctgaa gtgaagaagc ccggtgcctc tgtgaaggtg       60

agctgcaagg ccagcggcta caccttcacc agctacaaca tgcactgggt gagacaagct      120

cccggtcaag gtttagagtg gatgggcgtg atcaaccccg gtgatggtgc taccagctac      180

gcccagaagt tcaagggtcg tgtgaccatg accagagaca ccagcaccag caccgtgtac      240

atggagctga gctctttaag gagcgaggac accgccgtgt actactgcgc tcgtgactac      300

tacggcagca gccctttagg ctattgggga caaggtactt tagtgaccgt ctcgagcgcc      360

tcaaccaaag gaccctccgt gtttcccctc gccccctgtt cccgctccac atccgagtca      420

accgcggcgc tgggctgcct cgtgaaggac tacttccctg agcccgtcac tgtgtcgtgg      480

aactccgggg ccctgacctc cggcgtgcac accttccctg ccgtgcttca atcctccgga      540

ctgtactccc tgtcctcggt ggtcaccgtg ccgtcgagct cgttgggaac caagacttac      600

acttgcaacg tggaccacaa gccaagcaac accaaagtgg acaagagagt cgaatctaag      660

tacggaccgc cctgcccgcc ttgccccgcc cctgagtttc tcggcggtcc tagcgtgttc      720

ctgttcccac ccaagcccaa ggacactctg atgatctccc ggacccctga agtgacctgt      780

gtggtcgtgg acgtgtcgca ggaagatccg gaggtccagt tcaattggta cgtggatggg      840

gtggaggtcc acaacgccaa gacgaagccg agagaagaac agttcaactc aacttaccgg      900

gtggtgtccg tgctgaccgt gctgcatcag gattggctca acggaaagga gtacaagtgc      960

aaagtgtcca acaagggcct gcctagctca atcgaaaaga ccatttccaa ggccaagggc     1020

cagccgaggg aaccacaggt ctatactctg ccaccgagcc aagaagagat gaccaagaac     1080

caagtgtccc tgacttgcct ggtcaagggg ttctacccgt cggacatcgc agtggagtgg     1140

gagagcaacg gacagcctga aaacaattac aagaccaccc cgcccgtgct ggatagcgac     1200

ggttccttct tcctttactc gcgcctcacc gtcgacaaga gccggtggca ggagggcaac     1260

gtgttctcct gctccgtgat gcacgaagct ctgcataacc actacactca gaagtccttg     1320

tcgctgagcc tcggaaag                                                   1338


<210>  192
<211>  636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC

<400>  192
gacatccaga tgacccagag ccctagctct ttaagcgcca gcgtgggaga tcgtgtgacc       60

atcacttgtc gtgccagccc cagcatcagc tacatgaact ggtaccagca gaagcccggc      120

aaggccccca agctgctgat ctacgccacc agctctttag cctctggcgt gcctagcaga      180

ttcagcggca gcggaagcgg caccgacttc actttaacca tcagctcttt acagccagaa      240

gacttcgcca cctactactg ccaccagagg agcagcagcc ctaccttcgg ccaaggtacc      300

aagctcgaga tcaagagaac tgtggccgcg ccgtcagtgt ttatcttccc tccatcggat      360

gaacagctta agtccggcac ggcgtctgtg gtctgcctgc tcaataactt ttaccctagg      420

gaagctaaag tccaatggaa agtggataac gccctgcagt caggaaacag ccaggaatcg      480

gttaccgaac aggacagcaa ggacagcact tactccttgt cgtcgactct tactctgagc      540

aaggccgatt acgagaagca caaggtctac gcctgcgagg tcacccatca gggactctcg      600

tccccggtga ccaaatcctt caatagaggc gaatgc                                636


<210>  193
<211>  636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC

<400>  193
gacatccaga tgacccagag ccctagctct ttaagcgcct ctgtgggcga tcgtgtgacc       60

atcacttgta gcgccagccc cagcatcagc tacatgaact ggtaccagca gaagcccggc      120

aaggccccca agctgctgat ctacgccaca agctctttac ccagcggcgt gcctagcaga      180

ttcagcggca gcggaagcgg caccgacttc actttaacca tcagctcttt acagccagaa      240

gacttcgcca cctactactg ccaccagaga agcagcagcc ccaccttcgg ccaaggtaca      300

aagctcgaga tcaagagaac tgtggccgcg ccgtcagtgt ttatcttccc tccatcggat      360

gaacagctta agtccggcac ggcgtctgtg gtctgcctgc tcaataactt ttaccctagg      420

gaagctaaag tccaatggaa agtggataac gccctgcagt caggaaacag ccaggaatcg      480

gttaccgaac aggacagcaa ggacagcact tactccttgt cgtcgactct tactctgagc      540

aaggccgatt acgagaagca caaggtctac gcctgcgagg tcacccatca gggactctcg      600

tccccggtga ccaaatcctt caatagaggc gaatgc                                636


<210>  194
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC

<400>  194
caagttcagc tggtgcagag cggtgctgag gtgaaaaaac ccggtgcttc cgtgaaggtg       60

agctgcaagg ccagcggcta cacctttacc agctacaaca tgcactgggt gagacaagcc      120

cccggtcaag gtttagagtg gatcggcgtg atctaccccg gcaacggcga cacctcttac      180

aaccagaagt tcaagggtcg tgtgaccatg actcgtgaca cctccaccag caccgtgtac      240

atggagctga gctctttaag gagcgaggac acagccgtgt actactgcgc tcgtgactac      300

tacggcagca gccctctggg ctattggggc caaggtactt tagtgaccgt ctcgagcgcc      360

tcaaccaaag gaccctccgt gtttcccctc gccccctgtt cccgctccac atccgagtca      420

accgcggcgc tgggctgcct cgtgaaggac tacttccctg agcccgtcac tgtgtcgtgg      480

aactccgggg ccctgacctc cggcgtgcac accttccctg ccgtgcttca atcctccgga      540

ctgtactccc tgtcctcggt ggtcaccgtg ccgtcgagct cgttgggaac caagacttac      600

acttgcaacg tggaccacaa gccaagcaac accaaagtgg acaagagagt cgaatctaag      660

tacggaccgc cctgcccgcc ttgccccgcc cctgagtttc tcggcggtcc tagcgtgttc      720

ctgttcccac ccaagcccaa ggacactctg atgatctccc ggacccctga agtgacctgt      780

gtggtcgtgg acgtgtcgca ggaagatccg gaggtccagt tcaattggta cgtggatggg      840

gtggaggtcc acaacgccaa gacgaagccg agagaagaac agttcaactc aacttaccgg      900

gtggtgtccg tgctgaccgt gctgcatcag gattggctca acggaaagga gtacaagtgc      960

aaagtgtcca acaagggcct gcctagctca atcgaaaaga ccatttccaa ggccaagggc     1020

cagccgaggg aaccacaggt ctatactctg ccaccgagcc aagaagagat gaccaagaac     1080

caagtgtccc tgacttgcct ggtcaagggg ttctacccgt cggacatcgc agtggagtgg     1140

gagagcaacg gacagcctga aaacaattac aagaccaccc cgcccgtgct ggatagcgac     1200

ggttccttct tcctttactc gcgcctcacc gtcgacaaga gccggtggca ggagggcaac     1260

gtgttctcct gctccgtgat gcacgaagct ctgcataacc actacactca gaagtccttg     1320

tcgctgagcc tcggaaag                                                   1338


<210>  195
<211>  636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC

<400>  195
gacatccaga tgacccagag ccctagctct ttaagcgcct ctgtgggcga tcgtgtgacc       60

atcacttgta gcgccagcag cagcatcagc tacatgcact ggtaccagca gaagcccggc      120

aaggccccca agctgctgat ctacgacacc agcaagctgg ccagcggcgt gcctagcaga      180

ttcagcggca gcggaagcgg caccgacttc actttaacca tcagctcttt acagccagaa      240

gacttcgcca cctactactg ccaccagagg agcagctacc ccaccttcgg ccaaggtacc      300

aagctcgaga tcaagagaac tgtggccgcg ccgtcagtgt ttatcttccc tccatcggat      360

gaacagctta agtccggcac ggcgtctgtg gtctgcctgc tcaataactt ttaccctagg      420

gaagctaaag tccaatggaa agtggataac gccctgcagt caggaaacag ccaggaatcg      480

gttaccgaac aggacagcaa ggacagcact tactccttgt cgtcgactct tactctgagc      540

aaggccgatt acgagaagca caaggtctac gcctgcgagg tcacccatca gggactctcg      600

tccccggtga ccaaatcctt caatagaggc gaatgc                                636


<210>  196
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC

<400>  196
caagtgcagc tcgtgcagtc cggagccgaa gtcaagaagc ccggagcgtc agtgaaagtg       60

tcctgcaagg cctcgggcta cactttcaca agctacaaca tgcactgggt cagacaggca      120

cctgggcagg gtctggagtg gatgggagtg atctacccgg gcgacggcgc cacttcctac      180

gcccaaaagt tcaagggccg cgtgaccatg actagggaca cctcgacctc aaccgtgtac      240

atggaactga gctccctgcg gtccgaggat accgccgtgt actattgtgc tcgggactac      300

tacgggtcca gcccactggg atactgggga cagggtaccc ttgtcacggt gtcgtcagct      360

tccaccaagg gcccatccgt cttccccctg gcgccctgct ccaggagcac ctccgagagc      420

acagccgccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac gaagacctac      600

acctgcaatg tagatcacaa gcccagcaac accaaggtgg acaagagagt tgagtccaaa      660

tatggtcccc catgcccacc atgcccagca cctgagttcc tggggggacc atcagtcttc      720

ctgttccccc caaaacccaa ggacactctc atgatctccc ggacccctga ggtcacgtgc      780

gtggtggtgg acgtgagcca ggaagacccc gaggtccagt tcaactggta cgtggatggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agttcaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga acggcaagga gtacaagtgc      960

aaggtctcca acaaaggcct cccgtcctcc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag agccacaggt gtacaccctg cccccatccc aggaggagat gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caggctaacc gtggacaaga gcaggtggca ggaggggaat     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacaca gaagagcctc     1320

tccctgtctc tgggtaaa                                                   1338


<210>  197
<211>  636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC

<400>  197
gacatccaaa tgactcagtc cccgtcatcc ctgtcggcat ccgtgggaga cagagtcacc       60

attacgtgca gcgcgagccc gagcatttcc tatatgaact ggtaccagca gaagcccggg      120

aaagccccta agctgttgat ctacgccact tcctcactgg cttccggcgt gccatcccgg      180

ttctcgggtt ccggctcggg aaccgatttt acccttacta tctcgtccct gcaacccgag      240

gacttcgcca cctactactg tcaccagcgc tctagctacc ctacattcgg acagggcacc      300

aagctcgaaa tcaaacgaac tgtggctgca ccatctgtct tcatcttccc gccatctgat      360

gagcagttga aatctggaac tgcctctgtt gtgtgcctgc tgaataactt ctatcccaga      420

gaggccaaag tacagtggaa ggtggataac gccctccaat cgggtaactc ccaggagagt      480

gtcacagagc aggacagcaa ggacagcacc tacagcctca gcagcaccct gacgctgagc      540

aaagcagact acgagaaaca caaagtctac gcctgcgaag tcacccatca gggcctgagc      600

tcgcccgtca caaagagctt caacagggga gagtgt                                636


<210>  198
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC

<400>  198
caagtgcagc tcgtgcagtc cggagccgaa gtcaagaagc ccggagcgtc agtgaaagtg       60

tcctgcaagg cctcgggcta cactttcaca agctacaaca tgcactgggt cagacaggca      120

cctgggcagg gtctggagtg gattggagtg atctacccgg gcgacggctc cacttcctac      180

aaccaaaagt tccagggccg cgtgaccatg actagggaca cctcgacctc aaccgtgtac      240

atggaactga gctccctgcg gtccgaggat accgccgtgt actattgtgc tcgggactac      300

tacgggtcca gcccactggg atactgggga cagggtaccc ttgtcacggt gtcgtcagct      360

tccaccaagg gcccatccgt cttccccctg gcgccctgct ccaggagcac ctccgagagc      420

acagccgccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac gaagacctac      600

acctgcaatg tagatcacaa gcccagcaac accaaggtgg acaagagagt tgagtccaaa      660

tatggtcccc catgcccacc atgcccagca cctgagttcc tggggggacc atcagtcttc      720

ctgttccccc caaaacccaa ggacactctc atgatctccc ggacccctga ggtcacgtgc      780

gtggtggtgg acgtgagcca ggaagacccc gaggtccagt tcaactggta cgtggatggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agttcaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga acggcaagga gtacaagtgc      960

aaggtctcca acaaaggcct cccgtcctcc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag agccacaggt gtacaccctg cccccatccc aggaggagat gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caggctaacc gtggacaaga gcaggtggca ggaggggaat     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacaca gaagagcctc     1320

tccctgtctc tgggtaaa                                                   1338


<210>  199
<211>  635
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC

<400>  199
acatccaaat gactcagtcc ccgtcatccc tgtcggcatc cgtgggagac agagtcacca       60

ttacgtgcag cgcgagctca agcatttcct atatgaactg gtaccagcag aagcccggga      120

aagcccctaa gctgttgatc tacgccactt ccaagctgcc gtccggcgtg ccatcccggt      180

tctcgggttc cggctcggga accgatttta cccttactat ctcgtccctg caacccgagg      240

acttcgccac ctactactgt caccagcgct ctagcacccc tacattcgga cagggcacca      300

agctcgaaat caaacgaact gtggctgcac catctgtctt catcttcccg ccatctgatg      360

agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc tatcccagag      420

aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc caggagagtg      480

tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg acgctgagca      540

aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag ggcctgagct      600

cgcccgtcac aaagagcttc aacaggggag agtgt                                 635


<210>  200
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HC

<400>  200
caagtgcagc tcgtgcagtc cggagccgaa gtcaagaagc ccggagcgtc agtgaaagtg       60

tcctgcaagg cctcgggcta cactttcaca agctacaaca tgcactgggt cagacaggca      120

cctgggcagg gtctggagtg gatgggagtg atcaacccgg gcgacggcgc cacttcctac      180

gcccaaaagt tcaagggccg cgtgaccatg actagggaca cctcgacctc aaccgtgtac      240

atggaactga gctccctgcg gtccgaggat accgccgtgt actattgtgc tcgggactac      300

tacgggtcca gcccactggg atactgggga cagggtaccc ttgtcacggt gtcgtcagct      360

tccaccaagg gcccatccgt cttccccctg gcgccctgct ccaggagcac ctccgagagc      420

acagccgccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac gaagacctac      600

acctgcaatg tagatcacaa gcccagcaac accaaggtgg acaagagagt tgagtccaaa      660

tatggtcccc catgcccacc atgcccagca cctgagttcc tggggggacc atcagtcttc      720

ctgttccccc caaaacccaa ggacactctc atgatctccc ggacccctga ggtcacgtgc      780

gtggtggtgg acgtgagcca ggaagacccc gaggtccagt tcaactggta cgtggatggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agttcaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga acggcaagga gtacaagtgc      960

aaggtctcca acaaaggcct cccgtcctcc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag agccacaggt gtacaccctg cccccatccc aggaggagat gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caggctaacc gtggacaaga gcaggtggca ggaggggaat     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacaca gaagagcctc     1320

tccctgtctc tgggtaaa                                                   1338


<210>  201
<211>  636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC

<400>  201
gacatccaaa tgactcagtc cccgtcatcc ctgtcggcat ccgtgggaga cagagtcacc       60

attacgtgcc gcgcgagccc gagcatttcc tatatgaact ggtaccagca gaagcccggg      120

aaagccccta agctgttgat ctacgccact tcctcactgg cttccggcgt gccatcccgg      180

ttctcgggtt ccggctcggg aaccgatttt acccttacta tctcgtccct gcaacccgag      240

gacttcgcca cctactactg tcaccagcgc tctagcagcc ctacattcgg acagggcacc      300

aagctcgaaa tcaaacgaac tgtggctgca ccatctgtct tcatcttccc gccatctgat      360

gagcagttga aatctggaac tgcctctgtt gtgtgcctgc tgaataactt ctatcccaga      420

gaggccaaag tacagtggaa ggtggataac gccctccaat cgggtaactc ccaggagagt      480

gtcacagagc aggacagcaa ggacagcacc tacagcctca gcagcaccct gacgctgagc      540

aaagcagact acgagaaaca caaagtctac gcctgcgaag tcacccatca gggcctgagc      600

tcgcccgtca caaagagctt caacagggga gagtgt                                636


<210>  202
<211>  636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LC

<400>  202
gacatccaaa tgactcagtc cccgtcatcc ctgtcggcat ccgtgggaga cagagtcacc       60

attacgtgca gcgcgagccc gagcatttcc tatatgaact ggtaccagca gaagcccggg      120

aaagccccta agctgttgat ctacgccact tcctcactgc cgtccggcgt gccatcccgg      180

ttctcgggtt ccggctcggg aaccgatttt acccttacta tctcgtccct gcaacccgag      240

gacttcgcca cctactactg tcaccagcgc tctagcagcc ctacattcgg acagggcacc      300

aagctcgaaa tcaaacgaac tgtggctgca ccatctgtct tcatcttccc gccatctgat      360

gagcagttga aatctggaac tgcctctgtt gtgtgcctgc tgaataactt ctatcccaga      420

gaggccaaag tacagtggaa ggtggataac gccctccaat cgggtaactc ccaggagagt      480

gtcacagagc aggacagcaa ggacagcacc tacagcctca gcagcaccct gacgctgagc      540

aaagcagact acgagaaaca caaagtctac gcctgcgaag tcacccatca gggcctgagc      600

tcgcccgtca caaagagctt caacagggga gagtgt                                636


