<110>    JW Bioscience
         Curebio. Co., Ltd

<120>    Antibodies specifically binding to WRS protein and uses thereof

<130>    OP20-0032/PCT

<150>    KR 10-2019-0087233
<151>    2019-07-18

<160>    10

<170>    KoPatentIn 3.0

<210>    1
<211>    471
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    human tryptophanyl-tRNA synthetase(WRS) full length


<400>    1
Met Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn Ser Ile
  1               5                  10                  15 

Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn Ala Ser
             20                  25                  30 

Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu Lys Met
         35                  40                  45 

Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro Pro
     50                  55                  60 

Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu Ala
 65                  70                  75                  80 

Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala Lys
                 85                  90                  95 

Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys Ile
            100                 105                 110 

Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro
        115                 120                 125 

His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met Asn
    130                 135                 140 

Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr Thr
145                 150                 155                 160 

Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile Pro
                165                 170                 175 

Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val
            180                 185                 190 

Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu
        195                 200                 205 

Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile Ala
    210                 215                 220 

Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr
225                 230                 235                 240 

Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln Lys
                245                 250                 255 

His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp Ser
            260                 265                 270 

Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser
        275                 280                 285 

Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln
    290                 295                 300 

Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr
305                 310                 315                 320 

Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His
                325                 330                 335 

Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala
            340                 345                 350 

Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile
        355                 360                 365 

Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr Ile
    370                 375                 380 

Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser Phe
385                 390                 395                 400 

Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile
                405                 410                 415 

Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys
            420                 425                 430 

Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg
        435                 440                 445 

Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg
    450                 455                 460 

Lys Leu Ser Phe Asp Phe Gln
465                 470    


<210>    2
<211>    57
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Peptide fragment of human tryptophanyl-tRNA synthetase


<400>    2
Met Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro
  1               5                  10                  15 

Pro Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu
             20                  25                  30 

Ala Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala
         35                  40                  45 

Lys Gly Ile Asp Tyr Asp Lys Leu Ile
     50                  55        


<210>    3
<211>    14
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain CDR1 of anti-WRS monoclonal antiboty


<400>    3
Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn
  1               5                  10                


<210>    4
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain CDR2 of anti-WRS monoclonal antiboty


<400>    4
Gly Thr Asn Asn Arg Ala Pro
  1               5        


<210>    5
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain CDR3 of anti-WRS monoclonal antiboty


<400>    5
Val Leu Trp Tyr Ser Asn His Trp Val
  1               5                


<210>    6
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain CDR1 of anti-WRS monoclonal antiboty


<400>    6
Asp Tyr Asn Met Asn
  1               5


<210>    7
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain CDR2 of anti-WRS monoclonal antiboty


<400>    7
Val Ile Asn Pro Asn Tyr Gly Thr Ile Arg Tyr Asn Gln Lys Phe Lys
  1               5                  10                  15 

Gly
   


<210>    8
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain CDR3 of anti-WRS monoclonal antiboty


<400>    8
Leu Leu Arg Gly Tyr Tyr Ala Met Asp Tyr
  1               5                  10


<210>    9
<211>    128
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain variable region of anti-WRS monoclonal antiboty


<400>    9
Met Ala Trp Ile Ser Leu Ile Leu Ser Leu Leu Ala Leu Ser Ser Gly
  1               5                  10                  15 

Ala Ile Ser Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser
             20                  25                  30 

Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val
         35                  40                  45 

Thr Thr Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu
     50                  55                  60 

Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro
 65                  70                  75                  80 

Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile
                 85                  90                  95 

Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp
            100                 105                 110 

Tyr Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
        115                 120                 125 




<210>    10
<211>    138
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain variable region of anti-WRS monoclonal antiboty


<400>    10
Met Gly Trp Ser Trp Ile Phe Leu Leu Leu Leu Ser Gly Thr Ala Gly
  1               5                  10                  15 

Val His Ser Glu Phe Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys
             20                  25                  30 

Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe
         35                  40                  45 

Ile Asp Tyr Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu
     50                  55                  60 

Glu Trp Ile Gly Val Ile Asn Pro Asn Tyr Gly Thr Ile Arg Tyr Asn
 65                  70                  75                  80 

Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Gln Ser Ser Ser
                 85                  90                  95 

Thr Ala Tyr Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val
            100                 105                 110 

Tyr Tyr Cys Ala Gly Leu Leu Arg Gly Tyr Tyr Ala Met Asp Tyr Trp
        115                 120                 125 

Gly Gln Gly Thr Ser Val Thr Val Ser Ser
    130                 135            
