<110>    JW Bioscience
         Curebio. Co., Ltd.

<120>    Antibodies specifically binding to WRS protein and uses thereof

<130>    OP20-0031/PCT

<150>    KR 10-2019-0087230
<151>    2019-07-18

<160>    50

<170>    KoPatentIn 3.0

<210>    1
<211>    471
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    human tryptophanyl-tRNA synthetase(WRS) full length


<400>    1
Met Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn Ser Ile
  1               5                  10                  15 

Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn Ala Ser
             20                  25                  30 

Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu Lys Met
         35                  40                  45 

Ser Tyr Lys Ala Ala Ala Gly Glu Asp Tyr Lys Ala Asp Cys Pro Pro
     50                  55                  60 

Gly Asn Pro Ala Pro Thr Ser Asn His Gly Pro Asp Ala Thr Glu Ala
 65                  70                  75                  80 

Glu Glu Asp Phe Val Asp Pro Trp Thr Val Gln Thr Ser Ser Ala Lys
                 85                  90                  95 

Gly Ile Asp Tyr Asp Lys Leu Ile Val Arg Phe Gly Ser Ser Lys Ile
            100                 105                 110 

Asp Lys Glu Leu Ile Asn Arg Ile Glu Arg Ala Thr Gly Gln Arg Pro
        115                 120                 125 

His His Phe Leu Arg Arg Gly Ile Phe Phe Ser His Arg Asp Met Asn
    130                 135                 140 

Gln Val Leu Asp Ala Tyr Glu Asn Lys Lys Pro Phe Tyr Leu Tyr Thr
145                 150                 155                 160 

Gly Arg Gly Pro Ser Ser Glu Ala Met His Val Gly His Leu Ile Pro
                165                 170                 175 

Phe Ile Phe Thr Lys Trp Leu Gln Asp Val Phe Asn Val Pro Leu Val
            180                 185                 190 

Ile Gln Met Thr Asp Asp Glu Lys Tyr Leu Trp Lys Asp Leu Thr Leu
        195                 200                 205 

Asp Gln Ala Tyr Ser Tyr Ala Val Glu Asn Ala Lys Asp Ile Ile Ala
    210                 215                 220 

Cys Gly Phe Asp Ile Asn Lys Thr Phe Ile Phe Ser Asp Leu Asp Tyr
225                 230                 235                 240 

Met Gly Met Ser Ser Gly Phe Tyr Lys Asn Val Val Lys Ile Gln Lys
                245                 250                 255 

His Val Thr Phe Asn Gln Val Lys Gly Ile Phe Gly Phe Thr Asp Ser
            260                 265                 270 

Asp Cys Ile Gly Lys Ile Ser Phe Pro Ala Ile Gln Ala Ala Pro Ser
        275                 280                 285 

Phe Ser Asn Ser Phe Pro Gln Ile Phe Arg Asp Arg Thr Asp Ile Gln
    290                 295                 300 

Cys Leu Ile Pro Cys Ala Ile Asp Gln Asp Pro Tyr Phe Arg Met Thr
305                 310                 315                 320 

Arg Asp Val Ala Pro Arg Ile Gly Tyr Pro Lys Pro Ala Leu Leu His
                325                 330                 335 

Ser Thr Phe Phe Pro Ala Leu Gln Gly Ala Gln Thr Lys Met Ser Ala
            340                 345                 350 

Ser Asp Pro Asn Ser Ser Ile Phe Leu Thr Asp Thr Ala Lys Gln Ile
        355                 360                 365 

Lys Thr Lys Val Asn Lys His Ala Phe Ser Gly Gly Arg Asp Thr Ile
    370                 375                 380 

Glu Glu His Arg Gln Phe Gly Gly Asn Cys Asp Val Asp Val Ser Phe
385                 390                 395                 400 

Met Tyr Leu Thr Phe Phe Leu Glu Asp Asp Asp Lys Leu Glu Gln Ile
                405                 410                 415 

Arg Lys Asp Tyr Thr Ser Gly Ala Met Leu Thr Gly Glu Leu Lys Lys
            420                 425                 430 

Ala Leu Ile Glu Val Leu Gln Pro Leu Ile Ala Glu His Gln Ala Arg
        435                 440                 445 

Arg Lys Glu Val Thr Asp Glu Ile Val Lys Glu Phe Met Thr Pro Arg
    450                 455                 460 

Lys Leu Ser Phe Asp Phe Gln
465                 470    


<210>    2
<211>    47
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Peptide fragment of human tryptophanyl-tRNA synthetase


<400>    2
Met Pro Asn Ser Glu Pro Ala Ser Leu Leu Glu Leu Phe Asn Ser Ile
  1               5                  10                  15 

Ala Thr Gln Gly Glu Leu Val Arg Ser Leu Lys Ala Gly Asn Ala Ser
             20                  25                  30 

Lys Asp Glu Ile Asp Ser Ala Val Lys Met Leu Val Ser Leu Lys
         35                  40                  45 




<210>    3
<211>    126
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain variable region of anti-WRS monocalonal antibody
         3B10H5


<400>    3
Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln Gly
  1               5                  10                  15 

Thr Arg Cys Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala
             20                  25                  30 

Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile
         35                  40                  45 

Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys
     50                  55                  60 

Leu Leu Ile Ser Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg
 65                  70                  75                  80 

Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn
                 85                  90                  95 

Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Tyr Thr
            100                 105                 110 

Leu Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
        115                 120                 125 




<210>    4
<211>    140
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain variable region of anti-WRS monocalonal antibody
         3B10H5


<400>    4
Met Gly Phe Ser Arg Ile Phe Leu Phe Leu Leu Ser Val Thr Thr Gly
  1               5                  10                  15 

Val His Ser Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg
             20                  25                  30 

Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe
         35                  40                  45 

Thr Ser Tyr Asn Leu His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu
     50                  55                  60 

Lys Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn
 65                  70                  75                  80 

Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser
                 85                  90                  95 

Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val
            100                 105                 110 

Tyr Phe Cys Ala Arg Trp His Tyr Gly Ser Ser Tyr Tyr Ala Met Asp
        115                 120                 125 

Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
    130                 135                 140


<210>    5
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain CDR1 of anti-WRS monocalonal antibody 3B10H5


<400>    5
Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn
  1               5                  10    


<210>    6
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain CDR2 of anti-WRS monocalonal antibody 3B10H5


<400>    6
Tyr Thr Ser Arg Leu His Ser
  1               5        


<210>    7
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain CDR3 of anti-WRS monocalonal antibody 3B10H5


<400>    7
Gln Gln Gly Tyr Thr Leu Pro His Thr
  1               5                


<210>    8
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain CDR1 of anti-WRS monocalonal antibody 3B10H5


<400>    8
Ser Tyr Asn Leu His
  1               5


<210>    9
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain CDR2 of anti-WRS monocalonal antibody 3B10H5


<400>    9
Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys
  1               5                  10                  15 

Gly
   


<210>    10
<211>    12
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain CDR3 of anti-WRS monocalonal antibody 3B10H5


<400>    10
Trp His Tyr Gly Ser Ser Tyr Tyr Ala Met Asp Tyr
  1               5                  10        


<210>    11
<211>    131
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain variable region of anti-WRS monocalonal antibody
         6A3B4


<400>    11
Met Glu Lys Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro
  1               5                  10                  15 

Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala
             20                  25                  30 

Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser
         35                  40                  45 

Val Asp Asn Tyr Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro
     50                  55                  60 

Gly Gln Pro Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser
 65                  70                  75                  80 

Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser
                 85                  90                  95 

Leu Asn Ile His Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys
            100                 105                 110 

Gln Gln Ser Lys Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu
        115                 120                 125 

Glu Ile Lys
    130    


<210>    12
<211>    131
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain variable region of anti-WRS monocalonal antibody
         6A3B4


<400>    12
Met Arg Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
  1               5                  10                  15 

Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys
             20                  25                  30 

Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
         35                  40                  45 

Thr Asn Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu
     50                  55                  60 

Glu Trp Ile Gly Arg Ile His Pro Ser Ala Ser Asp Thr Asn Tyr Asn
 65                  70                  75                  80 

Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser
                 85                  90                  95 

Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val
            100                 105                 110 

Tyr Tyr Cys Ala Asn Ala Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr
        115                 120                 125 

Val Ser Ser
    130    


<210>    13
<211>    15
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain CDR1 of anti-WRS monocalonal antibody 6A3B4


<400>    13
Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn
  1               5                  10                  15


<210>    14
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain CDR2 of anti-WRS monocalonal antibody 6A3B4


<400>    14
Ala Ala Ser Asn Gln Gly Ser
  1               5        


<210>    15
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain CDR3 of anti-WRS monocalonal antibody 6A3B4


<400>    15
Gln Gln Ser Lys Glu Val Pro Trp Thr
  1               5                


<210>    16
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain CDR1 of anti-WRS monocalonal antibody 6A3B4


<400>    16
Asn Tyr Trp Met His
  1               5


<210>    17
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain CDR2 of anti-WRS monocalonal antibody 6A3B4


<400>    17
Arg Ile His Pro Ser Ala Ser Asp Thr Asn Tyr Asn Gln Lys Phe Lys
  1               5                  10                  15 

Gly
   


<210>    18
<211>    3
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain CDR3 of anti-WRS monocalonal antibody 6A3B4


<400>    18
Ala Asp Tyr
  1        


<210>    19
<211>    126
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain variable region of anti-WRS monocalonal antibody
         1D4C3


<400>    19
Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln Gly
  1               5                  10                  15 

Thr Arg Cys Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala
             20                  25                  30 

Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile
         35                  40                  45 

Ser Asn Tyr Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Val Lys
     50                  55                  60 

Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg
 65                  70                  75                  80 

Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn
                 85                  90                  95 

Leu Glu Gln Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Gly Lys Thr
            100                 105                 110 

Leu Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
        115                 120                 125 




<210>    20
<211>    140
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain variable region of anti-WRS monocalonal antibody
         1D4C3


<400>    20
Met Gly Phe Ser Arg Ile Phe Leu Phe Leu Leu Ser Val Thr Thr Gly
  1               5                  10                  15 

Val His Ser Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg
             20                  25                  30 

Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe
         35                  40                  45 

Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Arg Gln Gly Leu
     50                  55                  60 

Glu Trp Ile Gly Ala Ile Tyr Pro Gly Asn Gly Asp Ser Ser Tyr Asn
 65                  70                  75                  80 

Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Gly Lys Ser Ser Ser
                 85                  90                  95 

Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val
            100                 105                 110 

Tyr Phe Cys Ala Arg Trp His Tyr Gly Ser Thr Tyr Tyr Ala Met Asp
        115                 120                 125 

Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
    130                 135                 140


<210>    21
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain CDR1 of anti-WRS monocalonal antibody 1D4C3


<400>    21
Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn
  1               5                  10    


<210>    22
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain CDR2 of anti-WRS monocalonal antibody 1D4C3


<400>    22
Tyr Thr Ser Arg Leu His Ser
  1               5        


<210>    23
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain CDR3 of anti-WRS monocalonal antibody 1D4C3


<400>    23
Gln Gln Gly Lys Thr Leu Pro His Thr
  1               5                


<210>    24
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain CDR1 of anti-WRS monocalonal antibody 1D4C3


<400>    24
Ser Tyr Asn Met His
  1               5


<210>    25
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain CDR2 of anti-WRS monocalonal antibody 1D4C3


<400>    25
Ala Ile Tyr Pro Gly Asn Gly Asp Ser Ser Tyr Asn Gln Lys Phe Lys
  1               5                  10                  15 

Gly
   


<210>    26
<211>    12
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain CDR3 of anti-WRS monocalonal antibody 1D4C3


<400>    26
Trp His Tyr Gly Ser Thr Tyr Tyr Ala Met Asp Tyr
  1               5                  10        


<210>    27
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain variable region of anti-WRS monocalonal antibody 3B6


<400>    27
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
             20                  25                  30 

Asn Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Tyr Asn Ser His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ala Ser Leu
                 85                  90                  95 

Ser Ala Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 




<210>    28
<211>    121
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain variable region of anti-WRS monocalonal antibody 3B6


<400>    28
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
             20                  25                  30 

Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ala Ile Ser Tyr Asp Asn Gly Asn Thr Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Gly Ala Thr Thr Gln Pro His Thr Ser Phe Asp Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Asn Ser
        115                 120    


<210>    29
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain CDR1 of anti-WRS monocalonal antibody 3B6


<400>    29
Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Asn Val Ser
  1               5                  10            


<210>    30
<211>    4
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain CDR2 of anti-WRS monocalonal antibody 3B6


<400>    30
Tyr Asn Ser His
  1            


<210>    31
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain CDR3 of anti-WRS monocalonal antibody 3B6


<400>    31
Gly Thr Trp Asp Ala Ser Leu Ser Ala
  1               5                


<210>    32
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain CDR1 of anti-WRS monocalonal antibody 3B6


<400>    32
Ser Tyr Ser Met Ser
  1               5


<210>    33
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain CDR2 of anti-WRS monocalonal antibody 3B6


<400>    33
Ala Ile Ser Tyr Asp Asn Gly Asn Thr
  1               5                


<210>    34
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain CDR3 of anti-WRS monocalonal antibody 3B6


<400>    34
Lys Gly Ala Thr Thr Gln Pro His Thr Ser Phe Asp Tyr
  1               5                  10            


<210>    35
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain variable region of anti-WRS monocalonal antibody 4G4


<400>    35
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
             20                  25                  30 

Ser Val Thr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr His Asp Ser His Pro Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                 85                  90                  95 

Ser Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 




<210>    36
<211>    127
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain variable region of anti-WRS monocalonal antibody 4G4


<400>    36
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ser Asn Tyr
             20                  25                  30 

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Trp Ile Ser Pro Gly Asp Gly Asn Lys Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Arg Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Val Thr Ile Pro Cys Arg Arg Thr Thr Cys Tyr Ser Ala Asn
            100                 105                 110 

Gly Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125 




<210>    37
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain CDR1 of anti-WRS monocalonal antibody 4G4


<400>    37
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Ser Val Thr
  1               5                  10            


<210>    38
<211>    4
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain CDR2 of anti-WRS monocalonal antibody 4G4


<400>    38
His Asp Ser His
  1            


<210>    39
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain CDR3 of anti-WRS monocalonal antibody 4G4


<400>    39
Ala Ala Trp Asp Asp Ser Leu Ser Gly
  1               5                


<210>    40
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain CDR1 of anti-WRS monocalonal antibody 4G4


<400>    40
Asn Tyr Ala Met Ser
  1               5


<210>    41
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain CDR2 of anti-WRS monocalonal antibody 4G4


<400>    41
Trp Ile Ser Pro Gly Asp Gly Asn Lys
  1               5                


<210>    42
<211>    19
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain CDR3 of anti-WRS monocalonal antibody 4G4


<400>    42
Arg Val Thr Ile Pro Cys Arg Arg Thr Thr Cys Tyr Ser Ala Asn Gly
  1               5                  10                  15 

Met Asp Val
           


<210>    43
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain variable region of anti-WRS monocalonal antibody 4H9


<400>    43
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
             20                  25                  30 

Asp Val Thr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Asp Asn Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Trp Asp Asp Ser Leu
                 85                  90                  95 

Ser Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 




<210>    44
<211>    121
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain variable region of anti-WRS monocalonal antibody 4H9


<400>    44
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Pro Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
             20                  25                  30 

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ser Ile Tyr Pro Asp Gly Gly Gly Ile Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Asp Leu Tyr Pro Phe Gly Pro Asp Thr Phe Asp Tyr Trp Gly
            100                 105                 110 

Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120    


<210>    45
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain CDR1 of anti-WRS monocalonal antibody 4H9


<400>    45
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Asp Val Thr
  1               5                  10            


<210>    46
<211>    4
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain CDR2 of anti-WRS monocalonal antibody 4H9


<400>    46
Asp Asn Ser Lys
  1            


<210>    47
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain CDR3 of anti-WRS monocalonal antibody 4H9


<400>    47
Gly Ala Trp Asp Asp Ser Leu Ser Gly
  1               5                


<210>    48
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain CDR1 of anti-WRS monocalonal antibody 4H9


<400>    48
Asn Tyr Ala Met Ser
  1               5


<210>    49
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain CDR2 of anti-WRS monocalonal antibody 4H9


<400>    49
Ser Ile Tyr Pro Asp Gly Gly Gly Ile
  1               5                


<210>    50
<211>    13
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain CDR3 of anti-WRS monocalonal antibody 4H9


<400>    50
Arg Asp Leu Tyr Pro Phe Gly Pro Asp Thr Phe Asp Tyr
  1               5                  10            
