                         SEQUENCE LISTING

<110>  Ramot at Tel-Aviv University Ltd.
       FREUND, Natalia
       WEISS, Ronen
 
<120>  COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUBERCULOSIS

<130>  77991

<160>  131   

<170>  PatentIn version 3.5

<210>  1
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-110 IgH amino acid sequence

<400>  1

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg His 
            20                  25                  30          


Thr Met His Trp Val Arg Leu Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Leu Ser Ser Pro Thr Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gly Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Tyr Asp Gly Val Ala Ser Asp Pro His Phe 
            100                 105                 110         


Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  2
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  2

Gly Phe Thr Phe Ser Arg His Thr 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  3

Ile Leu Ser Ser Pro Thr Tyr Ile 
1               5               


<210>  4
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  4

Ala Arg Gly Asp Tyr Tyr Tyr Asp Gly Val Ala Ser Asp Pro His Phe 
1               5                   10                  15      


Asp Asn 
        


<210>  5
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-110 IgL amino acid sequence

<400>  5

Gln Ser Val Leu Thr Gln Thr Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Arg Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Phe Gln Gln Phe Pro Gly Ala Ala Pro Gln Leu Leu 
        35                  40                  45              


Ile Ser Arg Asn Ile Gln Arg Pro Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Asp Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala His Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  6
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  6

Arg Ser Asn Ile Gly Ser Asn Tyr 
1               5               


<210>  7
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  7

Arg Asn Ile 
1           


<210>  8
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  8

Ala Ala Trp Asp Asp Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  9
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-143 IgH amino acid sequence

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Ser His 
            20                  25                  30          


Arg Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ile Ser Ser Arg Thr Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Tyr Asp Gly Val Ala Ser Asp Pro His Phe 
            100                 105                 110         


Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  10
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  10

Gly Phe Thr Phe Glu Ser His Arg 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  11

Ile Ile Ser Ser Arg Thr Tyr Ile 
1               5               


<210>  12
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  12

Ala Arg Gly Asp Tyr Tyr Tyr Asp Gly Val Ala Ser Asp Pro His Phe 
1               5                   10                  15      


Asp Asn 
        


<210>  13
<211>  80
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-143 IgL amino acid sequence

<400>  13

Ser Asn Tyr Val Tyr Trp Phe Gln Gln Leu Pro Gly Thr Ala Pro Gln 
1               5                   10                  15      


Leu Leu Ile Tyr Arg Asn Ile Gln Arg Pro Ser Gly Val Pro Ala Arg 
            20                  25                  30          


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
        35                  40                  45              


Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp 
    50                  55                  60                  


Ser Leu Ser Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
65                  70                  75                  80  


<210>  14
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  14

Ser Asn Ile Gly Ser Asn Tyr 
1               5           


<210>  15
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  15

Arg Asn Ile 
1           


<210>  16
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  16

Ala Thr Trp Asp Asp Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  17
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-163 IgH amino acid sequence

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Ser His 
            20                  25                  30          


Arg Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ile Ser Ser Arg Thr Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Tyr Asp Gly Val Ala Ser Asp Pro His Phe 
            100                 105                 110         


Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  18
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  18

Gly Phe Thr Phe Glu Ser His Arg 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  19

Ile Ile Ser Ser Arg Thr Tyr Ile 
1               5               


<210>  20
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  20

Ala Arg Gly Asp Tyr Tyr Tyr Asp Gly Val Ala Ser Asp Pro His Phe 
1               5                   10                  15      


Asp Asn 
        


<210>  21
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-163 IgL amino acid sequence

<400>  21

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Gly Arg Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Phe Gln Gln Leu Pro Gly Thr Ala Pro Gln Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Ile Gln Arg Pro Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  22
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  22

Arg Ser Asn Ile Gly Ser Asn Tyr 
1               5               


<210>  23
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  23

Arg Asn Ile 
1           


<210>  24
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  24

Ala Thr Trp Asp Asp Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  25
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-123 IgH amino acid sequence

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Ser His 
            20                  25                  30          


Arg Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ile Ser Ser Arg Thr Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Tyr Asp Gly Val Ala Ser Asp Pro His Phe 
            100                 105                 110         


Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  26
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  26

Gly Phe Thr Phe Glu Ser His Arg 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  27

Ile Ile Ser Ser Arg Thr Tyr Ile 
1               5               


<210>  28
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  28

Ala Arg Gly Asp Tyr Tyr Tyr Asp Gly Val Ala Ser Asp Pro His Phe 
1               5                   10                  15      


Asp Asn 
        


<210>  29
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-123 IgL amino acid sequence

<400>  29

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Gly Arg Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Phe Gln Gln Leu Pro Gly Thr Ala Pro Gln Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Ile Gln Arg Pro Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  30
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  30

Arg Ser Asn Ile Gly Ser Asn Tyr 
1               5               


<210>  31
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  31

Arg Asn Ile 
1           


<210>  32
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  32

Ala Thr Trp Asp Asp Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  33
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-170 IgH amino acid sequence

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Arg Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ile Ser Ser Arg Thr Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gly Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Tyr Asp Gly Val Ala Ser Asp Pro His Phe 
            100                 105                 110         


Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  34
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  34

Gly Phe Thr Phe Ser Ser His Arg 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  35

Ile Ile Ser Ser Arg Thr Tyr Ile 
1               5               


<210>  36
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  36

Ala Arg Gly Asp Tyr Tyr Tyr Asp Gly Val Ala Ser Asp Pro His Phe 
1               5                   10                  15      


Asp Asn 
        


<210>  37
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-170 IgL amino acid sequence

<400>  37

Gln Ser Val Leu Thr Gln Thr Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Arg Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Phe Gln Gln Phe Pro Gly Ala Ala Pro Gln Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Ile Gln Arg Pro Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Asp Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala His Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  38
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  38

Arg Ser Asn Ile Gly Ser Asn Tyr 
1               5               


<210>  39
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  39

Arg Asn Ile 
1           


<210>  40
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  40

Ala Ala Trp Asp Asp Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  41
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-66 IgH amino acid sequence

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Arg Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ile Ser Ser Arg Thr Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gly Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Tyr Asp Gly Val Ala Ser Asp Pro His Phe 
            100                 105                 110         


Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  42
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  42

Gly Phe Thr Phe Ser Ser His Arg 
1               5               


<210>  43
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  43

Ile Ile Ser Ser Arg Thr Tyr Ile 
1               5               


<210>  44
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  44

Ala Arg Gly Asp Tyr Tyr Tyr Asp Gly Val Ala Ser Asp Pro His Phe 
1               5                   10                  15      


Asp Asn 
        


<210>  45
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-66 IgLamino acid sequence

<400>  45

Gln Ser Val Leu Thr Gln Thr Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Arg Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Phe Gln Gln Phe Pro Gly Ala Ala Pro Gln Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Ile Gln Arg Pro Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Asp Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala His Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  46
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  46

Arg Ser Asn Ile Gly Ser 
1               5       


<210>  47
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  47

Arg Asn Ile 
1           


<210>  48
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  48

Ala Ala Trp Asp Asp Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  49
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-9 IgHamino acid sequence

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Arg Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ile Ser Ser Arg Thr Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Arg Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Tyr Tyr Asp Gly Val Ala Ser Asp Pro His Phe 
            100                 105                 110         


Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  50
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  50

Gly Phe Thr Phe Ser Ser His Arg 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  51

Ile Ile Ser Ser Arg Thr Tyr Ile 
1               5               


<210>  52
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  52

Ala Arg Gly Asp Tyr Tyr Tyr Asp Gly Val Ala Ser Asp Pro His Phe 
1               5                   10                  15      


Asp Asn 
        


<210>  53
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-9 IgL amino acid sequence

<400>  53

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Arg Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Tyr Trp Phe Gln Gln Leu Pro Gly Thr Ala Pro Gln Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Ile Gln Arg Pro Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Ser Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  54
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  54

Arg Ser Asn Ile Gly Ser Asn Tyr 
1               5               


<210>  55
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  55

Arg Asn Ile 
1           


<210>  56
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  56

Ala Ala Trp Asp Asp Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  57
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-141 IgH amino acid sequence

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Thr Phe Thr Phe Asn Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Leu Ile Asn Pro Asp Gly Ser Thr Thr Lys Ser Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ala Tyr Ser Ser Gly Trp Tyr Lys Arg Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  58
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  58

Thr Phe Thr Phe Asn Ser Tyr Trp 
1               5               


<210>  59
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  59

Ile Asn Pro Asp Gly Ser Thr Thr 
1               5               


<210>  60
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  60

Ala Gly Ala Tyr Ser Ser Gly Trp Tyr Lys Arg 
1               5                   10      


<210>  61
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-141 IgL amino acid sequence

<400>  61

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser Arg Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Gln Leu Leu Leu 
        35                  40                  45              


Tyr Gly Ala Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asn Val Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  62
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  62

Gln Gly Ile Ser Arg Ser 
1               5       


<210>  63
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  63

Gly Ala Ser 
1           


<210>  64
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  64

Gln Gln Tyr Tyr Asn Val Pro Tyr Thr 
1               5                   


<210>  65
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-48 IgH amino acid sequence

<400>  65

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Thr Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Leu Ile Asn Pro Asp Gly Ser Thr Thr Lys Ser Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ala Tyr Ser Ser Gly Trp Tyr Lys Arg Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Ala Val Ser Ser 
        115             


<210>  66
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  66

Thr Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  67
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  67

Ile Asn Pro Asp Gly Ser Thr Thr 
1               5               


<210>  68
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  68

Ala Gly Ala Tyr Ser Ser Gly Trp Tyr Lys Arg 
1               5                   10      


<210>  69
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-85 IgH amino acid sequence

<400>  69

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Thr Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Leu Ile Asn Pro Asp Gly Ser Thr Thr Lys Ser Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ala Tyr Ser Ser Gly Trp Tyr Lys Arg Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Ala Val Ser Ser 
        115             


<210>  70
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  70

Ile Asn Pro Asp Gly Ser Thr Thr 
1               5               


<210>  71
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  71

Thr Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  72
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  72

Ala Gly Ala Tyr Ser Ser Gly Trp Tyr Lys Arg 
1               5                   10      


<210>  73
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-107 IgH amino acid sequence

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Asp Ser Gly Phe Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Val 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Thr Gly Pro Arg Pro Tyr Tyr Asp Ser Ser Gly Tyr Tyr Pro 
            100                 105                 110         


Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  74
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  74

Gly Phe Thr Phe Ser Glu Tyr Ala 
1               5               


<210>  75
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  75

Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr 
1               5                   10  


<210>  76
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  76

Thr Gly Pro Arg Pro Tyr Tyr Asp Ser Ser Gly Tyr Tyr Pro Tyr Tyr 
1               5                   10                  15      


Phe Asp Tyr 
            


<210>  77
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-107 IgL amino acid sequence

<400>  77

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ser Arg Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Arg Val Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Phe Ala Gly Ser 
                85                  90                  95      


Ser Thr Tyr Val Val Phe Gly Gly Gly Thr Thr Leu Thr Val Leu 
            100                 105                 110     


<210>  78
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  78

Arg Ser Asp Val Gly Gly Tyr Asp Tyr 
1               5                   


<210>  79
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  79

Asp Val Thr 
1           


<210>  80
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  80

Ser Ser Phe Ala Gly Ser Ser Thr Tyr Val Val 
1               5                   10      


<210>  81
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-36 IgH amino acid sequence

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Asp Ser Gly Phe Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Val 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Phe Cys Thr Gly Pro Arg Pro Tyr Tyr Asp Ser Ser Gly Tyr Tyr Pro 
            100                 105                 110         


Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  82
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  82

Gly Phe Thr Phe Ser Glu Tyr Ala 
1               5               


<210>  83
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  83

Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr 
1               5                   10  


<210>  84
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  84

Thr Gly Pro Arg Pro Tyr Tyr Asp Ser Ser Gly Tyr Tyr Pro Tyr Tyr 
1               5                   10                  15      


Phe Asp Tyr 
            


<210>  85
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-36 IgLamino acid sequence

<400>  85

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Ser Arg Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asp Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Arg Val Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Phe Ala Gly Ser 
                85                  90                  95      


Ser Thr Tyr Val Val Phe Gly Gly Gly Thr Thr Leu Thr Val Leu 
            100                 105                 110     


<210>  86
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  86

Arg Ser Asp Val Gly Gly Tyr Asp Tyr 
1               5                   


<210>  87
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  87

Asp Val Thr 
1           


<210>  88
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  88

Ser Ser Phe Ala Gly Ser Ser Thr Tyr Val Val 
1               5                   10      


<210>  89
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-31 IgH amino acid sequence

<400>  89

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Asn Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ala Cys Val Ala Ser Gly His Asn Phe Ser Asp Phe 
            20                  25                  30          


Tyr Phe His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Val Lys Gly Gly Gly Gly Val Thr Gly Tyr Pro Gln Arg Leu 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Arg Thr Ile Tyr 
65                  70                  75                  80  


Leu Glu Leu Lys Asn Leu Thr Ser Asp Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Gly Cys Asn Gly Gly Ser Cys Tyr Tyr Phe Asp His 
            100                 105                 110         


Trp Gly Arg Gly Thr Leu Val Thr 
        115                 120 


<210>  90
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  90

Gly His Asn Phe Ser Asp Phe Tyr 
1               5               


<210>  91
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  91

Val Lys Gly Gly Gly Gly Val Thr 
1               5               


<210>  92
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  92

Ala Arg Asp Pro Gly Cys Asn Gly Gly Ser Cys Tyr Tyr Phe Asp His 
1               5                   10                  15      


<210>  93
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-31 IgLamino acid sequence

<400>  93

Ser Tyr Glu Leu Thr Gln Ser Thr Ser Met Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Thr Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr Ala 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Gln Ala Pro Thr Leu Leu Ile Tyr 
        35                  40                  45              


Lys Asp Asn Gln Arg Ser Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Thr Thr Leu Thr Leu Thr Ile Ser Gly Val Gln Thr Glu 
65                  70                  75                  80  


Asp Glu Ala Val Tyr His Cys Gln Ser Ser Asp Ile Thr Ser Arg Phe 
                85                  90                  95      


Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  94
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  94

Ala Leu Pro Lys Gln Tyr 
1               5       


<210>  95
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  95

Lys Asp Asn 
1           


<210>  96
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  96

Gln Ser Ser Asp Ile Thr Ser Arg Phe Val Ile 
1               5                   10      


<210>  97
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-62 IgH amino acid sequence

<400>  97

Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
1               5                   10                  15      


Leu Arg Leu Ala Cys Thr Ala Ser Gly Tyr Asn Phe Ser Asp Phe Tyr 
            20                  25                  30          


Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Ile Val Lys Gly Gly Gly Gly Val Thr Gly Tyr Pro Gln Ala Leu Arg 
    50                  55                  60                  


Ser Arg Val Thr Met Thr Thr Asp Thr Ser Thr Thr Thr Val Tyr Met 
65                  70                  75                  80  


Glu Leu Lys Asn Ile Ser Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Pro Gly Cys Asn Gly Gly Ser Cys Tyr Tyr Phe Asp His Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  98
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  98

Gly Tyr Asn Phe Ser Asp Phe Tyr 
1               5               


<210>  99
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  99

Val Lys Gly Gly Gly Gly Val Thr 
1               5               


<210>  100
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  100

Ala Arg Asp Pro Gly Cys Asn Gly Gly Ser Cys Tyr Tyr Phe Asp His 
1               5                   10                  15      


<210>  101
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-13 IgH amino acid sequence

<400>  101

Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Tyr 
            20                  25                  30          


Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        35                  40                  45              


Tyr Ile Ser Ser Ser Gly Gly Thr Val Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Ala Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Leu Asp Ser Ala Ser Trp Ser Gly Tyr Tyr Tyr Tyr Tyr Ser 
            100                 105                 110         


Met Tyr Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  102
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  102

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  103
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  103

Ile Ser Ser Ser Gly Gly Thr Val 
1               5               


<210>  104
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  104

Ala Arg Asp Leu Asp Ser Ala Ser Trp Ser Gly Tyr Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Ser Met Tyr Val 
            20  


<210>  105
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  P4-67 IgH amino acid sequence

<400>  105

Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Tyr 
            20                  25                  30          


Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Gln Glu Trp Val Ser 
        35                  40                  45              


Tyr Ile Ser Ser Ser Gly Gly Thr Val Tyr Tyr Ala Asp Ser Gly Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Gly Gln Tyr Gln 
65                  70                  75                  80  


Gln Met Asn Ser Glu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Asp Val Asp Ser Ala Ser Trp Ser Gly Tyr Tyr Tyr Tyr Tyr Ser 
            100                 105                 110         


Met Tyr Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  106
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  106

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  107
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  107

Ile Ser Ser Ser Gly Gly Thr Val 
1               5               


<210>  108
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  complementarity determining region (CDR) amino acid sequence

<400>  108

Ala Arg Asp Val Asp Ser Ala Ser Trp Ser Gly Tyr Tyr Tyr Tyr Tyr 
1               5                   10                  15      


Ser Met Tyr Val 
            20  


<210>  109
<211>  370
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4-31 HC

<400>  109
ccaggtgcag ctggtgcagt ctggggccga ggtgaagaac cctggggcct cagtgaaaat       60

tgcctgcgtg gcatctgggc acaacttcag cgacttctat ttccactggg tgcgacaggc      120

ccctggacaa ggcctggaat ggatgggaat tgtcaaagga ggtggtggtg tcacaggata      180

cccacagagg ttgaagggtc gagtcaccat gaccacagac acgtccacga gaacaatcta      240

tctggaactg aaaaatttaa cttctgacga cacggccact tattattgtg cgagagaccc      300

tggatgtaat ggtgggagct gttattattt tgaccattgg ggccggggaa ccctggtcac      360

cgtctcctca                                                             370


<210>  110
<211>  324
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4-31 LC nucleic acid sequence

<400>  110
tcctatgagc tgactcagtc aacctcgatg tctgtgtccc caggacagac ggccacgatc       60

acctgctctg gagatgcatt gccgaaacaa tatgcttatt ggtaccagca gaagtcaggc      120

caggccccaa ctttgctgat atataaagac aatcagaggt cttcagggat ccctgaccgg      180

ttctctggct ccagctcagg gacaacactc accttgacca tcagtggagt ccagacagag      240

gacgaggctg tctatcactg tcaatcatct gacatcacta gtcgttttgt gattttcggc      300

ggagggacca aactgaccgt cctg                                             324


<210>  111
<211>  385
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4-36 HC nucleic acid sequence

<400>  111
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc cagggcggtc cctgagactc       60

tcctgtacag actctggatt cacctttagt gaatatgctc tgagctgggt acgccaggct      120

ccagggaagg ggctggagtg ggtcggtttc attagaagca aagcttatgg tgggacaaca      180

gaatacgccg cgtctgtgaa gggcagattc accatctcaa gagatgattc caaaagtgtc      240

gcctatctgc agatgaacag cctgaaaacc gaggacacag ccgtgtattt ctgtactggg      300

cctcggcctt attatgatag tagcggttat tacccgtatt attttgacta ctggggccag      360

ggaaccctgg tcaccgtctc ctcag                                            385


<210>  112
<211>  333
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4-36 LC nucleic acid sequence

<400>  112
cagtctgccc tgactcagcc tcgctcagtg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gcagcaggag tgatgtcggt ggttatgact atgtctcctg gtaccaacag      120

cacccaggca gagtccccaa actcatgatt tatgatgtca ctaagcggcc ctctggggtc      180

cctgatcgct tctctggctc caggtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgacg atgaggctga ttattactgc tcctcatttg caggcagctc cacttatgtg      300

gttttcggcg gcgggaccac gctgaccgtc cta                                   333


<210>  113
<211>  354
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4-48 HC nucleic acid sequence

<400>  113
gaggtgcagc tggtggagtc cgggggaggc ttagttcagc ctggggggtc cctgagactc       60

tcctgtgcag cctccacatt cactttcagt agctactgga tgcactgggt ccgccaagct      120

ccagggaagg gactggtgtg ggtgtcactt attaatcctg atggcagtac cacgaagtcc      180

gcggactccg tgaagggccg attcaccatc tccagagaca acgccgagaa cactttgtat      240

ctgcaaatga acagtctgag agccgacgac acagctatat attactgcgc cggagcttat      300

agcagtggct ggtataagag gtggggccag ggaaccctgg tcaccgtctc ctca            354


<210>  114
<211>  360
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4-62 HC nucleic acid sequence

<400>  114
caggtgcagc tggtgcagtc tggggccgag gtgaagaagc ctggggcctc actgagactt       60

gcctgcacgg catctggata caacttcagc gacttctata tacactgggt gcgacaggcc      120

cctggacaag ggctggagtg gatgggaatc gtcaaaggag gtggtggtgt cacgggctac      180

ccacaggcgt tgcggagtag agtcaccatg accacagaca cgtccacgac tacagtctat      240

atggaattga agaatataag ttctgaagat acggccattt attattgtgc gagagaccct      300

ggatgtaatg gtgggagttg ttactacttt gaccattggg gccggggaac cctggtcacc      360


<210>  115
<211>  376
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4-66 HC nucleic acid sequence

<400>  115
gaggtgcagc tggtggagtc ggggggaggc ctggtcaagc cgggggggtc cctgagactc       60

tcctgtgcag cctccggatt caccttcagt agccatagga tgcactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attattagta gtcgaactta tatatactat      180

gcagactcag tgaagggccg attcaccatc tccagagaca actccgggaa ctcactgttt      240

ctgcaaatga acagcctgag agtcgaggac acggctgttt attactgtgc gcgaggagac      300

tactactatg atggtgttgc ctcagaccct cactttgaca actggggcca gggaaccctg      360

gtcaccgtct cctcag                                                      376


<210>  116
<211>  330
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4-66 LC nucleic acid sequence

<400>  116
cagtctgtgc tgactcagac accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gcagcaggtc caacattgga agtaattacg tatactggtt ccagcagttc      120

ccaggagcgg ccccccaact cctcatctat aggaatattc agcggccctc aggggtccct      180

gcccgattct ctggctccaa gtctgacacc tcagcctcac tggccatcag tggactccgg      240

tccgaggatg aggctcatta ttactgtgca gcatgggatg acagcctgag tggtgtggtt      300

ttcggcggag ggaccaaggt gaccgtccta                                       330


<210>  117
<211>  354
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4-85 HC nucleic acid sequence

<400>  117
gaggtgcagc tggtggagtc cgggggaggc ttagttcagc ctggggggtc cctgagactc       60

tcctgtgcag cctccacatt cactttcagt agctactgga tgcactgggt ccgccaagct      120

ccagggaagg ggctggtgtg ggtgtcactt attaatcctg atggcagtac cacaaagtcc      180

gcggactccg tgaagggccg attcaccatc tccagagaca acgccgagaa cactttgtat      240

ctgcaaatga acagtctgag agccgaggac acagctatat attactgcgc cggagcttat      300

agcagtggct ggtataagag gtggggccag ggaaccctgg tcaccgtctc ctca            354


<210>  118
<211>  385
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4-107 HC nucleic acid sequence

<400>  118
tgaggtgcag ctggtggagt ctgggggagg cttggtacag ccagggcggt ccctgagact       60

ctcctgtaca gactctggat tcacctttag tgaatatgct ctgagctggg tacgccaggc      120

tccagggaag gggctggagt gggtcggttt cattagaagc aaagcttatg gtgggacaac      180

agaatacgcc gcgtctgtga agggcagatt caccatctca agagatgatt ccaaaagtgt      240

cgcctatctg caaatgaaca gcctgaaaac cgaggacaca gccgtgtatt tctgtactgg      300

gcctcggcct tattatgata gtagcggtta ttacccgtat tattttgact actggggcca      360

gggaaccctg gtcaccgtct cctca                                            385


<210>  119
<211>  333
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4-107 LC nucleic acid sequence

<400>  119
cagtctgccc tgactcagcc tcgctcagtg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gcagcaggag tgatgtcggt ggttatgact atgtctcctg gtaccaacag      120

cacccaggca gagtccccaa actcatgatt tatgatgtca ctaagcggcc ctctggggtc      180

cctgatcgct tctctggctc caggtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgacg atgaggctga ttattactgc tcctcatttg cagacagctc cacttatgtg      300

gttttcggcg gcgggaccac gctgaccgtc cta                                   333


<210>  120
<211>  375
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4-123 HC nucleic acid sequence

<400>  120
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcgaa agccatagga tgcactgggt ccgccaggct      120

ccagggaagg ggctagaatg ggtctcatcc attattagta gtcgaactta catatactac      180

gcagactcag tgaagggccg attcaccatc tccagagaca actccaggaa ctcactcttt      240

ctacaaatga acagcctgag agccgaggac acggctgtgt attactgtgc acgaggagac      300

tactactatg atggtgttgc ctcagatcct cactttgaca actggggcca gggaaccctg      360

gtcaccgtct cctca                                                       375


<210>  121
<211>  330
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4-123 LC nucleic acid sequence

<400>  121
cagtctgtgc tgacgcagcc accctcagcg tctgggaccc ccggtcagag ggtcaccatc       60

tcttgttctg gcggcaggtc caacatcgga agtaattatg tatactggtt ccagcagctc      120

ccaggaacgg ccccccaact cctcatctat aggaatattc agcggccctc aggggtccct      180

gcccgattct ctggctccaa gtctggcacc tcagcctcac tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca acatgggatg acagcctgag tggtgtggtt      300

ttcggcggag ggaccaaggt gaccgtccta                                       330


<210>  122
<211>  355
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4-141 HC nucleic acid sequence

<400>  122
tgaggtgcag ctggtggagt ccgggggagg cttagttcag cctggggggt ccctgagact       60

ctcctgtgca gcctccacat tcactttcaa tagctactgg atgcactggg tccgccaagc      120

tccagggaag gggctggtgt gggtgtcact tattaatcct gatggcagta ccacaaagtc      180

cgcggactcc gtgaagggcc gattcaccat ctccagagac aacgccgaga acactttgta      240

tctgcaaatg aacagtctga gagccgagga cacagctata tattactgcg ccggagctta      300

tagcagtggc tggtataaga ggtggggcca gggaaccctg gtcaccgtct cctca           355


<210>  123
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4-141 LC nucleic acid sequence

<400>  123
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtgggaga cagagtcacc       60

atctcttgcc gggcgagtca gggcattagc aggtctttag cctggtatca gcagaaacca      120

gggaaagccc ctcagctcct gctctatggt gcgtccagat tggaaagtgg ggtcccatcc      180

aggttcagtg gcactggatc tgggacggat tacactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacaa tattataatg ttccctatac ttttggccag      300

gggaccaagc tggagattaa a                                                321


<210>  124
<211>  375
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4-163 HC nucleic acid sequence

<400>  124
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcgaa agccatagga tgcactgggt ccgccaggct      120

ccagggaagg ggctagaatg ggtctcatcc attattagta gtcgaactta catatactac      180

gcagactcag tgaagggccg attcaccatc tccagagaca actccaggaa ctcactcttt      240

ctacaaatga acagcctgag agccgaggac acggctgtgt attactgtgc acgaggagac      300

tactactatg atggtgttgc ctcagatcct cactttgaca actggggcca gggaaccctg      360

gtcaccgtct cctca                                                       375


<210>  125
<211>  330
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4-163 LC nucleic acid sequence

<400>  125
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccggtcagag ggtcaccatc       60

tcttgttctg gcggcaggtc caacatcgga agtaattatg tatactggtt ccagcagctc      120

ccaggaacgg ccccccaact cctcatctat aggaatattc agcggccctc aggggtccct      180

gcccgattct ctggctccaa gtctggcacc tcagcctcac tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca acatgggatg acagcctgag tggtgtggtt      300

ttcggcggag ggaccaaggt gaccgtccta                                       330


<210>  126
<211>  375
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4-170 HC nucleic acid sequence

<400>  126
gaggtgcagc tggtggagtc ggggggaggc ctggtcaagc cgggtgggtc cctgagactc       60

tcctgtgcag cctccggatt caccttcagt agccatagga tgcactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attattagta gtcgaactta tatatactac      180

gcagactcag tgaagggccg attcaccatc tccagagaca actccgggaa ctcactgttt      240

ctgcaaatga acagcctgag agtcgaggac acggctgttt attactgtgc gcgaggagac      300

tactactatg atggtgttgc ctcagaccct cactttgaca actggggcca gggaaccctg      360

gtcaccgtct cctca                                                       375


<210>  127
<211>  330
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4-170 LC nucleic acid sequence

<400>  127
cagtctgtgc tgacgcagac accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gcagcaggtc caacattgga agtaattacg tatactggtt ccagcagttc      120

ccaggagcgg ccccccaact cctcatctat aggaatattc agcggccctc aggggtccct      180

gcccgattct ctggctccaa gtctgacacc tcagcctcac tggccatcag tggactccgg      240

tccgaggatg aggctcatta ttactgtgca gcatgggatg acagcctgag tggtgtggtt      300

ttcggcggag ggaccaaggt gaccgtccta                                       330


<210>  128
<211>  385
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4-36GL_HC nucleic acid sequence

<400>  128
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc cagggcggtc cctgagactc       60

tcctgtacag cttctggatt cacctttggt gattatgcta tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtaggtttc attagaagca aagcttatgg tgggacaaca      180

gaatacgccg cgtctgtgaa aggcagattc accatctcaa gagatgattc caaaagcatc      240

gcctatctgc aaatgaacag cctgaaaacc gaggacacag ccgtgtatta ctgtactggg      300

cctcggcctt attatgatag tagcggttat tacccgtatt attttgacta ctggggccag      360

ggaaccctgg tcaccgtctc ctcag                                            385


<210>  129
<211>  333
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4-36GL_LC nucleic acid sequence

<400>  129
cagtctgccc tgactcagcc tcgctcagtg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgatgttggt ggttataact atgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgatgtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg atgaggctga ttattactgc tgctcatatg caggcagcta cacttatgtg      300

gtattcggcg gagggaccaa gctgaccgtc cta                                   333


<210>  130
<211>  376
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4-163GL_HC nucleic acid sequence

<400>  130
gaggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatagca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtagtta catatactac      180

gcagactcag tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagaggagac      300

tactactatg atggtgttgc ctcagatcct cactttgaca actggggcca gggaaccctg      360

gtcaccgtct cctcag                                                      376


<210>  131
<211>  330
<212>  DNA
<213>  Artificial sequence

<220>
<223>  P4-163GL_LC nucleic acid sequence

<400>  131
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaattatg tatactggta ccagcagctc      120

ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct      180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg      240

tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgag tggtgtggta      300

ttcggcggag ggaccaagct gaccgtccta                                       330


