                         SEQUENCE LISTING

<110>  MedImmune Limited
 
<120>  Tripartite systems for protein dimerization and methods of use

<130>  007660186

<150>  US 62/874025
<151>  2019-07-15

<160>  247   

<170>  PatentIn version 3.5

<210>  1
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Wild-type HCV NS3/4A PR

<400>  1

Met Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser 
1               5                   10                  15      


Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys Gln 
            20                  25                  30          


Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val 
        35                  40                  45              


Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile Asn 
    50                  55                  60                  


Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala 
65                  70                  75                  80  


Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp 
                85                  90                  95      


Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys 
            100                 105                 110         


Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val 
        115                 120                 125             


Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro 
    130                 135                 140                 


Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu Cys 
145                 150                 155                 160 


Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr Arg 
                165                 170                 175     


Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr 
            180                 185                 190         


Thr Met Arg Ser Pro 
        195         


<210>  2
<211>  197
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCV NS3/4A PR (S139A)

<400>  2

Met Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser 
1               5                   10                  15      


Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys Gln 
            20                  25                  30          


Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val 
        35                  40                  45              


Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile Asn 
    50                  55                  60                  


Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala 
65                  70                  75                  80  


Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp 
                85                  90                  95      


Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys 
            100                 105                 110         


Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val 
        115                 120                 125             


Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro 
    130                 135                 140                 


Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys 
145                 150                 155                 160 


Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr Arg 
                165                 170                 175     


Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr 
            180                 185                 190         


Thr Met Arg Ser Pro 
        195         


<210>  3
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Wild-type HCV NS3/4A PR with N-terminal 6His and AviTag

<400>  3

Met Gly Ser Ser His His His His His His Gly Ser Gly Leu Asn Asp 
1               5                   10                  15      


Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly Gly Gly Gly Ser 
            20                  25                  30          


Met Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser 
        35                  40                  45              


Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys Gln 
    50                  55                  60                  


Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val 
65                  70                  75                  80  


Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile Asn 
                85                  90                  95      


Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala 
            100                 105                 110         


Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp 
        115                 120                 125             


Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys 
    130                 135                 140                 


Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val 
145                 150                 155                 160 


Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro 
                165                 170                 175     


Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu Cys 
            180                 185                 190         


Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr Arg 
        195                 200                 205             


Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr 
    210                 215                 220                 


Thr Met Arg Ser Pro 
225                 


<210>  4
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCV NS3/4A PR (S139A) with N-terminal 6His and AviTag

<400>  4

Met Gly Ser Ser His His His His His His Gly Ser Gly Leu Asn Asp 
1               5                   10                  15      


Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly Gly Gly Gly Ser 
            20                  25                  30          


Met Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser 
        35                  40                  45              


Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys Gln 
    50                  55                  60                  


Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val 
65                  70                  75                  80  


Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile Asn 
                85                  90                  95      


Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala 
            100                 105                 110         


Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp 
        115                 120                 125             


Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys 
    130                 135                 140                 


Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val 
145                 150                 155                 160 


Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro 
                165                 170                 175     


Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys 
            180                 185                 190         


Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr Arg 
        195                 200                 205             


Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr 
    210                 215                 220                 


Thr Met Arg Ser Pro 
225                 


<210>  5
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_23

<400>  5

Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr 
1               5                   10                  15      


Thr Ala Leu Ile Thr Trp Val Asp Pro Arg Tyr Asp Asp Ile Trp Trp 
            20                  25                  30          


Phe Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr 
        35                  40                  45              


Ile Lys Leu Tyr Leu Asn Asp Pro Tyr Tyr Ser Ile Gly Asn Leu Lys 
    50                  55                  60                  


Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Tyr Thr Gly Asp Ser 
65                  70                  75                  80  


Tyr Ser Arg Ser Gly Ser Asn Pro Ala Lys Ile Thr Phe Lys Thr Gly 
                85                  90                  95      


Leu 
    


<210>  6
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_32

<400>  6

Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr 
1               5                   10                  15      


Thr Ala Leu Ile Thr Trp Trp Ser Pro Arg Tyr Tyr Tyr Ala Ser Ile 
            20                  25                  30          


Ser Gly Phe Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg 
        35                  40                  45              


Thr Thr Ile Lys Leu Asp Tyr Ala Ser Asn Asp Tyr Ser Ile Gly Asn 
    50                  55                  60                  


Leu Lys Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Trp Asn Tyr 
65                  70                  75                  80  


Gly Asp Trp Arg Tyr Ser Ser Ser Asn Pro Ala Lys Ile Thr Phe Lys 
                85                  90                  95      


Thr Gly Leu 
            


<210>  7
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_33

<400>  7

Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr 
1               5                   10                  15      


Thr Ala Leu Ile Thr Trp Tyr Pro Pro Gly Arg Trp Tyr Asp Asp Ile 
            20                  25                  30          


Trp Tyr Phe Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg 
        35                  40                  45              


Thr Thr Ile Lys Leu Ala Arg Gly Asp Asp Val Tyr Ser Ile Gly Asn 
    50                  55                  60                  


Leu Lys Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Trp Gly Pro 
65                  70                  75                  80  


Asp Arg Gly Asp Arg Ala Gly Ser Asn Pro Ala Lys Ile Thr Phe Lys 
                85                  90                  95      


Thr Gly Leu 
            


<210>  8
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_36

<400>  8

Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr 
1               5                   10                  15      


Thr Ala Leu Ile Thr Trp Ser Trp Pro Arg Asp Asp Asp Tyr Asp Ile 
            20                  25                  30          


Trp Tyr Phe Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg 
        35                  40                  45              


Thr Thr Ile Lys Leu Leu Asn Tyr Ala Ser Pro Tyr Ser Ile Gly Asn 
    50                  55                  60                  


Leu Lys Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Val Val Pro 
65                  70                  75                  80  


Asp Thr Tyr Gly Arg Gly Thr Ser Asn Pro Ala Lys Ile Thr Phe Lys 
                85                  90                  95      


Thr Gly Leu 
            


<210>  9
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_47

<400>  9

Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr 
1               5                   10                  15      


Thr Ala Leu Ile Thr Trp Ser Arg Pro Gly Val Ser Ile Trp Tyr Phe 
            20                  25                  30          


Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr Ile 
        35                  40                  45              


Lys Leu Asp Tyr Arg Ser Tyr Tyr Tyr Ser Ile Gly Asn Leu Lys Pro 
    50                  55                  60                  


Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Gly Ser Tyr Gly Leu Val 
65                  70                  75                  80  


Gly Val Arg Ala Ser Asn Pro Ala Lys Ile Thr Phe Lys Thr Gly Leu 
                85                  90                  95      


<210>  10
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_01

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gln Gly Tyr Ile Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln Pro Pro Ser 
    130                 135                 140                 


Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser 
145                 150                 155                 160 


Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro 
                165                 170                 175     


Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser 
            180                 185                 190         


Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
        195                 200                 205             


Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Ala Ala Trp Asp His His Trp Glu Gln Val Val Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Thr Val Leu 
                245 


<210>  11
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_04

<400>  11

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Met Ala His Phe Tyr Gln Phe Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln Pro Pro Ser 
    130                 135                 140                 


Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser 
145                 150                 155                 160 


Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro 
                165                 170                 175     


Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser 
            180                 185                 190         


Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
        195                 200                 205             


Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Ala Ala Gly Asp His Asp His Glu His Val Val Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Thr Val Leu 
                245 


<210>  12
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_57

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Thr Asn Tyr Ile Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln Pro Pro Ser 
    130                 135                 140                 


Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser 
145                 150                 155                 160 


Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro 
                165                 170                 175     


Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser 
            180                 185                 190         


Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
        195                 200                 205             


Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Ala Ala Trp Asp His His Trp Glu Gln Val Val Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Thr Val Leu 
                245 


<210>  13
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_67

<400>  13

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ala Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Val Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Ser Gly Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Thr Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Met Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Asp Tyr Gly Gly Pro Leu Ala Asn Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Leu Ser Tyr Glu Leu Thr Gln Pro Pro Ser 
    130                 135                 140                 


Val Ser Glu Ala Pro Arg Gln Arg Val Thr Ile Ser Cys Ser Gly Ser 
145                 150                 155                 160 


Ser Ser Asn Ile Gly Asn Asn Ala Val Asn Trp Tyr Gln Gln Leu Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Phe Tyr Asp Asp Leu Leu Pro Ser 
            180                 185                 190         


Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
        195                 200                 205             


Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Ala Ala Trp Asp Asp Ser Leu Asn Gly Leu Val Phe Gly Thr Gly Thr 
225                 230                 235                 240 


Lys Leu Thr Val Leu 
                245 


<210>  14
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_72

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Met Ala His Phe Tyr Gln Phe Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln Pro Pro Ser 
    130                 135                 140                 


Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser 
145                 150                 155                 160 


Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro 
                165                 170                 175     


Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser 
            180                 185                 190         


Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
        195                 200                 205             


Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Ala Ala Gly Asp His Asp His Glu His Val Val Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Thr Val Leu 
                245 


<210>  15
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_75

<400>  15

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Asn Ser Tyr 
            20                  25                  30          


Thr Leu Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Val Phe Gly Ser Pro Asn Tyr Gly Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Val Tyr Gln Pro Leu Asp Ser Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Ala Gln Ala Val Leu Thr Gln Pro Ser Ser Ala 
    130                 135                 140                 


Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser 
145                 150                 155                 160 


Ser Asn Ile Gly Ser Tyr Thr Val Asn Trp Tyr Gln Gln Phe Pro Gly 
                165                 170                 175     


Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Thr Gln Arg Pro Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu 
        195                 200                 205             


Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala 
    210                 215                 220                 


Ala Trp Asp Asp Ser Leu Asn Gly Trp Val Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Thr Val Leu 
                


<210>  16
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LgBiT

<400>  16

Met Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala 
1               5                   10                  15      


Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu 
            20                  25                  30          


Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg 
        35                  40                  45              


Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr 
    50                  55                  60                  


Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys 
65                  70                  75                  80  


Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr 
                85                  90                  95      


Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe 
            100                 105                 110         


Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr 
        115                 120                 125             


Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu 
    130                 135                 140                 


Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn 
145                 150                 155             


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SmBiT

<400>  17

Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu 
1               5                   10      


<210>  18
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCV_NS4A_NS3_S139A_SmBiT

<400>  18

Met Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser 
1               5                   10                  15      


Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys Gln 
            20                  25                  30          


Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val 
        35                  40                  45              


Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile Asn 
    50                  55                  60                  


Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala 
65                  70                  75                  80  


Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp 
                85                  90                  95      


Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys 
            100                 105                 110         


Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val 
        115                 120                 125             


Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro 
    130                 135                 140                 


Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys 
145                 150                 155                 160 


Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr Arg 
                165                 170                 175     


Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr 
            180                 185                 190         


Thr Met Arg Ser Pro Gly Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        195                 200                 205             


Gly Ser Ser Gly Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu 
    210                 215                 220             


<210>  19
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SmBiT_HCV_NS4A_NS3_S139A

<400>  19

Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Ser Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Lys Lys Lys Gly Ser 
            20                  25                  30          


Val Val Ile Val Gly Arg Ile Asn Leu Ser Gly Asp Thr Ala Tyr Ala 
        35                  40                  45              


Gln Gln Thr Arg Gly Glu Glu Gly Cys Gln Glu Thr Ser Gln Thr Gly 
    50                  55                  60                  


Arg Asp Lys Asn Gln Val Glu Gly Glu Val Gln Ile Val Ser Thr Ala 
65                  70                  75                  80  


Thr Gln Thr Phe Leu Ala Thr Ser Ile Asn Gly Val Leu Trp Thr Val 
                85                  90                  95      


Tyr His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val 
            100                 105                 110         


Thr Gln Met Tyr Thr Asn Val Asp Lys Asp Leu Val Gly Trp Gln Ala 
        115                 120                 125             


Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp 
    130                 135                 140                 


Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg 
145                 150                 155                 160 


Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu 
                165                 170                 175     


Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val 
            180                 185                 190         


Gly Ile Phe Arg Ala Ala Val Ser Thr Arg Gly Val Ala Lys Ala Val 
        195                 200                 205             


Asp Phe Ile Pro Val Glu Ser Leu Glu Thr Thr Met Arg Ser Pro 
    210                 215                 220             


<210>  20
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_23_LgBiT

<400>  20

Met Gly Ser Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val 
1               5                   10                  15      


Thr Asp Thr Thr Ala Leu Ile Thr Trp Val Asp Pro Arg Tyr Asp Asp 
            20                  25                  30          


Ile Trp Trp Phe Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp 
        35                  40                  45              


Arg Thr Thr Ile Lys Leu Tyr Leu Asn Asp Pro Tyr Tyr Ser Ile Gly 
    50                  55                  60                  


Asn Leu Lys Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Tyr Thr 
65                  70                  75                  80  


Gly Asp Ser Tyr Ser Arg Ser Gly Ser Asn Pro Ala Lys Ile Thr Phe 
                85                  90                  95      


Lys Thr Gly Leu Ser Gly Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            100                 105                 110         


Gly Ser Ser Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu 
        115                 120                 125             


Gln Thr Ala Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val 
    130                 135                 140                 


Ser Ser Leu Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg 
145                 150                 155                 160 


Ile Val Arg Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile 
                165                 170                 175     


Ile Pro Tyr Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu 
            180                 185                 190         


Val Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile 
        195                 200                 205             


Leu Pro Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu 
    210                 215                 220                 


Asn Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys 
225                 230                 235                 240 


Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp 
                245                 250                 255     


Glu Arg Leu Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile 
            260                 265                 270         


Asn 
    


<210>  21
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_32_LgBiT

<400>  21

Met Gly Ser Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val 
1               5                   10                  15      


Thr Asp Thr Thr Ala Leu Ile Thr Trp Trp Ser Pro Arg Tyr Tyr Tyr 
            20                  25                  30          


Ala Ser Ile Ser Gly Phe Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro 
        35                  40                  45              


Gly Asp Arg Thr Thr Ile Lys Leu Asp Tyr Ala Ser Asn Asp Tyr Ser 
    50                  55                  60                  


Ile Gly Asn Leu Lys Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser 
65                  70                  75                  80  


Trp Asn Tyr Gly Asp Trp Arg Tyr Ser Ser Ser Asn Pro Ala Lys Ile 
                85                  90                  95      


Thr Phe Lys Thr Gly Leu Ser Gly Ser Ser Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Ser Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp 
        115                 120                 125             


Trp Glu Gln Thr Ala Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly 
    130                 135                 140                 


Gly Val Ser Ser Leu Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile 
145                 150                 155                 160 


Gln Arg Ile Val Arg Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His 
                165                 170                 175     


Val Ile Ile Pro Tyr Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile 
            180                 185                 190         


Glu Glu Val Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys 
        195                 200                 205             


Val Ile Leu Pro Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn 
    210                 215                 220                 


Met Leu Asn Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp 
225                 230                 235                 240 


Gly Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile 
                245                 250                 255     


Ile Asp Glu Arg Leu Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val 
            260                 265                 270         


Thr Ile Asn 
        275 


<210>  22
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_33_LgBiT

<400>  22

Met Gly Ser Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val 
1               5                   10                  15      


Thr Asp Thr Thr Ala Leu Ile Thr Trp Tyr Pro Pro Gly Arg Trp Tyr 
            20                  25                  30          


Asp Asp Ile Trp Tyr Phe Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro 
        35                  40                  45              


Gly Asp Arg Thr Thr Ile Lys Leu Ala Arg Gly Asp Asp Val Tyr Ser 
    50                  55                  60                  


Ile Gly Asn Leu Lys Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser 
65                  70                  75                  80  


Trp Gly Pro Asp Arg Gly Asp Arg Ala Gly Ser Asn Pro Ala Lys Ile 
                85                  90                  95      


Thr Phe Lys Thr Gly Leu Ser Gly Ser Ser Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Ser Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp 
        115                 120                 125             


Trp Glu Gln Thr Ala Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly 
    130                 135                 140                 


Gly Val Ser Ser Leu Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile 
145                 150                 155                 160 


Gln Arg Ile Val Arg Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His 
                165                 170                 175     


Val Ile Ile Pro Tyr Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile 
            180                 185                 190         


Glu Glu Val Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys 
        195                 200                 205             


Val Ile Leu Pro Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn 
    210                 215                 220                 


Met Leu Asn Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp 
225                 230                 235                 240 


Gly Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile 
                245                 250                 255     


Ile Asp Glu Arg Leu Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val 
            260                 265                 270         


Thr Ile Asn 
        275 


<210>  23
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_36_LgBiT

<400>  23

Met Gly Ser Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val 
1               5                   10                  15      


Thr Asp Thr Thr Ala Leu Ile Thr Trp Ser Trp Pro Arg Asp Asp Asp 
            20                  25                  30          


Tyr Asp Ile Trp Tyr Phe Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro 
        35                  40                  45              


Gly Asp Arg Thr Thr Ile Lys Leu Leu Asn Tyr Ala Ser Pro Tyr Ser 
    50                  55                  60                  


Ile Gly Asn Leu Lys Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser 
65                  70                  75                  80  


Val Val Pro Asp Thr Tyr Gly Arg Gly Thr Ser Asn Pro Ala Lys Ile 
                85                  90                  95      


Thr Phe Lys Thr Gly Leu Ser Gly Ser Ser Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Ser Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp 
        115                 120                 125             


Trp Glu Gln Thr Ala Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly 
    130                 135                 140                 


Gly Val Ser Ser Leu Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile 
145                 150                 155                 160 


Gln Arg Ile Val Arg Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His 
                165                 170                 175     


Val Ile Ile Pro Tyr Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile 
            180                 185                 190         


Glu Glu Val Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys 
        195                 200                 205             


Val Ile Leu Pro Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn 
    210                 215                 220                 


Met Leu Asn Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp 
225                 230                 235                 240 


Gly Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile 
                245                 250                 255     


Ile Asp Glu Arg Leu Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val 
            260                 265                 270         


Thr Ile Asn 
        275 


<210>  24
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_47_LgBiT

<400>  24

Met Gly Ser Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val 
1               5                   10                  15      


Thr Asp Thr Thr Ala Leu Ile Thr Trp Ser Arg Pro Gly Val Ser Ile 
            20                  25                  30          


Trp Tyr Phe Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg 
        35                  40                  45              


Thr Thr Ile Lys Leu Asp Tyr Arg Ser Tyr Tyr Tyr Ser Ile Gly Asn 
    50                  55                  60                  


Leu Lys Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Gly Ser Tyr 
65                  70                  75                  80  


Gly Leu Val Gly Val Arg Ala Ser Asn Pro Ala Lys Ile Thr Phe Lys 
                85                  90                  95      


Thr Gly Leu Ser Gly Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            100                 105                 110         


Ser Ser Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln 
        115                 120                 125             


Thr Ala Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 
    130                 135                 140                 


Ser Leu Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile 
145                 150                 155                 160 


Val Arg Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile 
                165                 170                 175     


Pro Tyr Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val 
            180                 185                 190         


Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 
        195                 200                 205             


Pro Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn 
    210                 215                 220                 


Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 
225                 230                 235                 240 


Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 
                245                 250                 255     


Arg Leu Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn 
            260                 265                 270         


<210>  25

<400>  25
000

<210>  26
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_06_LgBiT

<400>  26

Met Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
1               5                   10                  15      


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
            20                  25                  30          


Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
        35                  40                  45              


Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala 
    50                  55                  60                  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser 
65                  70                  75                  80  


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Ala Gly Tyr Tyr Met Arg Val Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys 
145                 150                 155                 160 


Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln 
                165                 170                 175     


Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr 
        195                 200                 205             


Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Ala Trp Asp His Asp Val Glu His Val Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu Ser Gly Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Ser Gly Val Phe Thr Leu Glu Asp Phe Val 
            260                 265                 270         


Gly Asp Trp Glu Gln Thr Ala Ala Tyr Asn Leu Asp Gln Val Leu Glu 
        275                 280                 285             


Gln Gly Gly Val Ser Ser Leu Leu Gln Asn Leu Ala Val Ser Val Thr 
    290                 295                 300                 


Pro Ile Gln Arg Ile Val Arg Ser Gly Glu Asn Ala Leu Lys Ile Asp 
305                 310                 315                 320 


Ile His Val Ile Ile Pro Tyr Glu Gly Leu Ser Ala Asp Gln Met Ala 
                325                 330                 335     


Gln Ile Glu Glu Val Phe Lys Val Val Tyr Pro Val Asp Asp His His 
            340                 345                 350         


Phe Lys Val Ile Leu Pro Tyr Gly Thr Leu Val Ile Asp Gly Val Thr 
        355                 360                 365             


Pro Asn Met Leu Asn Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val 
    370                 375                 380                 


Phe Asp Gly Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn 
385                 390                 395                 400 


Lys Ile Ile Asp Glu Arg Leu Ile Thr Pro Asp Gly Ser Met Leu Phe 
                405                 410                 415     


Arg Val Thr Ile Asn 
            420     


<210>  27
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_57_LgBiT

<400>  27

Met Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
1               5                   10                  15      


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
            20                  25                  30          


Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
        35                  40                  45              


Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala 
    50                  55                  60                  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser 
65                  70                  75                  80  


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg His Thr Asn Tyr Ile Thr Val Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys 
145                 150                 155                 160 


Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln 
                165                 170                 175     


Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr 
        195                 200                 205             


Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Ala Trp Asp His His Trp Glu Gln Val Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu Ser Gly Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Ser Gly Val Phe Thr Leu Glu Asp Phe Val 
            260                 265                 270         


Gly Asp Trp Glu Gln Thr Ala Ala Tyr Asn Leu Asp Gln Val Leu Glu 
        275                 280                 285             


Gln Gly Gly Val Ser Ser Leu Leu Gln Asn Leu Ala Val Ser Val Thr 
    290                 295                 300                 


Pro Ile Gln Arg Ile Val Arg Ser Gly Glu Asn Ala Leu Lys Ile Asp 
305                 310                 315                 320 


Ile His Val Ile Ile Pro Tyr Glu Gly Leu Ser Ala Asp Gln Met Ala 
                325                 330                 335     


Gln Ile Glu Glu Val Phe Lys Val Val Tyr Pro Val Asp Asp His His 
            340                 345                 350         


Phe Lys Val Ile Leu Pro Tyr Gly Thr Leu Val Ile Asp Gly Val Thr 
        355                 360                 365             


Pro Asn Met Leu Asn Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val 
    370                 375                 380                 


Phe Asp Gly Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn 
385                 390                 395                 400 


Lys Ile Ile Asp Glu Arg Leu Ile Thr Pro Asp Gly Ser Met Leu Phe 
                405                 410                 415     


Arg Val Thr Ile Asn 
            420     


<210>  28
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_67_LgBiT

<400>  28

Met Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
1               5                   10                  15      


Pro Gly Ala Ala Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Val Phe 
            20                  25                  30          


Thr Ser Tyr Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
        35                  40                  45              


Glu Trp Met Gly Val Ile Asn Pro Ser Gly Gly Asn Thr Asn Tyr Ala 
    50                  55                  60                  


Gln Lys Phe Gln Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Thr 
65                  70                  75                  80  


Thr Val Tyr Met Glu Leu Ser Ser Leu Met Phe Asp Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Lys Arg Asp Tyr Gly Gly Pro Leu Ala Asn Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Ser Tyr Glu Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Val Ser Glu Ala Pro Arg Gln Arg Val Thr Ile Ser Cys 
145                 150                 155                 160 


Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn Trp Tyr Gln 
                165                 170                 175     


Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu Ile Phe Tyr Asp Asp Leu 
            180                 185                 190         


Leu Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr 
        195                 200                 205             


Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Leu Val Phe Gly 
225                 230                 235                 240 


Thr Gly Thr Lys Leu Thr Val Leu Ser Gly Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Ser Gly Val Phe Thr Leu Glu Asp Phe Val 
            260                 265                 270         


Gly Asp Trp Glu Gln Thr Ala Ala Tyr Asn Leu Asp Gln Val Leu Glu 
        275                 280                 285             


Gln Gly Gly Val Ser Ser Leu Leu Gln Asn Leu Ala Val Ser Val Thr 
    290                 295                 300                 


Pro Ile Gln Arg Ile Val Arg Ser Gly Glu Asn Ala Leu Lys Ile Asp 
305                 310                 315                 320 


Ile His Val Ile Ile Pro Tyr Glu Gly Leu Ser Ala Asp Gln Met Ala 
                325                 330                 335     


Gln Ile Glu Glu Val Phe Lys Val Val Tyr Pro Val Asp Asp His His 
            340                 345                 350         


Phe Lys Val Ile Leu Pro Tyr Gly Thr Leu Val Ile Asp Gly Val Thr 
        355                 360                 365             


Pro Asn Met Leu Asn Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val 
    370                 375                 380                 


Phe Asp Gly Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn 
385                 390                 395                 400 


Lys Ile Ile Asp Glu Arg Leu Ile Thr Pro Asp Gly Ser Met Leu Phe 
                405                 410                 415     


Arg Val Thr Ile Asn 
            420     


<210>  29
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_72_LgBiT

<400>  29

Met Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
1               5                   10                  15      


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
            20                  25                  30          


Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
        35                  40                  45              


Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala 
    50                  55                  60                  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser 
65                  70                  75                  80  


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Met Ala His Phe Tyr Gln Phe Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys 
145                 150                 155                 160 


Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln 
                165                 170                 175     


Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr 
        195                 200                 205             


Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Ala Gly Asp His Asp His Glu His Val Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu Ser Gly Ser Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Ser Gly Val Phe Thr Leu Glu Asp Phe Val 
            260                 265                 270         


Gly Asp Trp Glu Gln Thr Ala Ala Tyr Asn Leu Asp Gln Val Leu Glu 
        275                 280                 285             


Gln Gly Gly Val Ser Ser Leu Leu Gln Asn Leu Ala Val Ser Val Thr 
    290                 295                 300                 


Pro Ile Gln Arg Ile Val Arg Ser Gly Glu Asn Ala Leu Lys Ile Asp 
305                 310                 315                 320 


Ile His Val Ile Ile Pro Tyr Glu Gly Leu Ser Ala Asp Gln Met Ala 
                325                 330                 335     


Gln Ile Glu Glu Val Phe Lys Val Val Tyr Pro Val Asp Asp His His 
            340                 345                 350         


Phe Lys Val Ile Leu Pro Tyr Gly Thr Leu Val Ile Asp Gly Val Thr 
        355                 360                 365             


Pro Asn Met Leu Asn Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val 
    370                 375                 380                 


Phe Asp Gly Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn 
385                 390                 395                 400 


Lys Ile Ile Asp Glu Arg Leu Ile Thr Pro Asp Gly Ser Met Leu Phe 
                405                 410                 415     


Arg Val Thr Ile Asn 
            420     


<210>  30
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_75_LgBiT

<400>  30

Met Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
1               5                   10                  15      


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Phe 
            20                  25                  30          


Asn Ser Tyr Thr Leu Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
        35                  40                  45              


Glu Trp Met Gly Gly Ile Ile Pro Val Phe Gly Ser Pro Asn Tyr Gly 
    50                  55                  60                  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser 
65                  70                  75                  80  


Thr Ala Tyr Met Glu Leu Ser Ser Leu Lys Ser Asp Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Leu Val Tyr Gln Pro Leu Asp Ser Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ala Val Leu Thr Gln Pro 
    130                 135                 140                 


Ser Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser 
145                 150                 155                 160 


Gly Ser Ser Ser Asn Ile Gly Ser Tyr Thr Val Asn Trp Tyr Gln Gln 
                165                 170                 175     


Phe Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Thr Gln Arg 
            180                 185                 190         


Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser 
        195                 200                 205             


Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Thr Val Leu Ser Gly Ser Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Ser Gly Val Phe Thr Leu Glu Asp Phe Val Gly 
            260                 265                 270         


Asp Trp Glu Gln Thr Ala Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln 
        275                 280                 285             


Gly Gly Val Ser Ser Leu Leu Gln Asn Leu Ala Val Ser Val Thr Pro 
    290                 295                 300                 


Ile Gln Arg Ile Val Arg Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile 
305                 310                 315                 320 


His Val Ile Ile Pro Tyr Glu Gly Leu Ser Ala Asp Gln Met Ala Gln 
                325                 330                 335     


Ile Glu Glu Val Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe 
            340                 345                 350         


Lys Val Ile Leu Pro Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro 
        355                 360                 365             


Asn Met Leu Asn Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe 
    370                 375                 380                 


Asp Gly Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys 
385                 390                 395                 400 


Ile Ile Asp Glu Arg Leu Ile Thr Pro Asp Gly Ser Met Leu Phe Arg 
                405                 410                 415     


Val Thr Ile Asn 
            420 


<210>  31
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LgBiT_PRSIM_23

<400>  31

Met Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala 
1               5                   10                  15      


Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu 
            20                  25                  30          


Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg 
        35                  40                  45              


Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr 
    50                  55                  60                  


Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys 
65                  70                  75                  80  


Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr 
                85                  90                  95      


Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe 
            100                 105                 110         


Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr 
        115                 120                 125             


Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu 
    130                 135                 140                 


Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly 
145                 150                 155                 160 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Arg Leu 
                165                 170                 175     


Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala 
            180                 185                 190         


Leu Ile Thr Trp Val Asp Pro Arg Tyr Asp Asp Ile Trp Trp Phe Glu 
        195                 200                 205             


Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr Ile Lys 
    210                 215                 220                 


Leu Tyr Leu Asn Asp Pro Tyr Tyr Ser Ile Gly Asn Leu Lys Pro Asp 
225                 230                 235                 240 


Thr Glu Tyr Glu Val Ser Leu Ile Ser Tyr Thr Gly Asp Ser Tyr Ser 
                245                 250                 255     


Arg Ser Gly Ser Asn Pro Ala Lys Ile Thr Phe Lys Thr Gly Leu 
            260                 265                 270     


<210>  32
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LgBiT_PRSIM_32

<400>  32

Met Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala 
1               5                   10                  15      


Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu 
            20                  25                  30          


Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg 
        35                  40                  45              


Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr 
    50                  55                  60                  


Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys 
65                  70                  75                  80  


Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr 
                85                  90                  95      


Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe 
            100                 105                 110         


Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr 
        115                 120                 125             


Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu 
    130                 135                 140                 


Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly 
145                 150                 155                 160 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Arg Leu 
                165                 170                 175     


Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala 
            180                 185                 190         


Leu Ile Thr Trp Trp Ser Pro Arg Tyr Tyr Tyr Ala Ser Ile Ser Gly 
        195                 200                 205             


Phe Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr 
    210                 215                 220                 


Ile Lys Leu Asp Tyr Ala Ser Asn Asp Tyr Ser Ile Gly Asn Leu Lys 
225                 230                 235                 240 


Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Trp Asn Tyr Gly Asp 
                245                 250                 255     


Trp Arg Tyr Ser Ser Ser Asn Pro Ala Lys Ile Thr Phe Lys Thr Gly 
            260                 265                 270         


Leu 
    


<210>  33
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LgBiT_PRSIM_33

<400>  33

Met Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala 
1               5                   10                  15      


Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu 
            20                  25                  30          


Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg 
        35                  40                  45              


Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr 
    50                  55                  60                  


Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys 
65                  70                  75                  80  


Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr 
                85                  90                  95      


Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe 
            100                 105                 110         


Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr 
        115                 120                 125             


Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu 
    130                 135                 140                 


Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly 
145                 150                 155                 160 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Arg Leu 
                165                 170                 175     


Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala 
            180                 185                 190         


Leu Ile Thr Trp Tyr Pro Pro Gly Arg Trp Tyr Asp Asp Ile Trp Tyr 
        195                 200                 205             


Phe Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr 
    210                 215                 220                 


Ile Lys Leu Ala Arg Gly Asp Asp Val Tyr Ser Ile Gly Asn Leu Lys 
225                 230                 235                 240 


Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Trp Gly Pro Asp Arg 
                245                 250                 255     


Gly Asp Arg Ala Gly Ser Asn Pro Ala Lys Ile Thr Phe Lys Thr Gly 
            260                 265                 270         


Leu 
    


<210>  34
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LgBiT_PRSIM_36

<400>  34

Met Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala 
1               5                   10                  15      


Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu 
            20                  25                  30          


Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg 
        35                  40                  45              


Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr 
    50                  55                  60                  


Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys 
65                  70                  75                  80  


Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr 
                85                  90                  95      


Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe 
            100                 105                 110         


Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr 
        115                 120                 125             


Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu 
    130                 135                 140                 


Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly 
145                 150                 155                 160 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Arg Leu 
                165                 170                 175     


Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala 
            180                 185                 190         


Leu Ile Thr Trp Ser Trp Pro Arg Asp Asp Asp Tyr Asp Ile Trp Tyr 
        195                 200                 205             


Phe Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr 
    210                 215                 220                 


Ile Lys Leu Leu Asn Tyr Ala Ser Pro Tyr Ser Ile Gly Asn Leu Lys 
225                 230                 235                 240 


Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Val Val Pro Asp Thr 
                245                 250                 255     


Tyr Gly Arg Gly Thr Ser Asn Pro Ala Lys Ile Thr Phe Lys Thr Gly 
            260                 265                 270         


Leu 
    


<210>  35
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LgBiT_PRSIM_47

<400>  35

Met Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala 
1               5                   10                  15      


Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu 
            20                  25                  30          


Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg 
        35                  40                  45              


Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr 
    50                  55                  60                  


Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys 
65                  70                  75                  80  


Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr 
                85                  90                  95      


Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe 
            100                 105                 110         


Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr 
        115                 120                 125             


Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu 
    130                 135                 140                 


Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly 
145                 150                 155                 160 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Arg Leu 
                165                 170                 175     


Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala 
            180                 185                 190         


Leu Ile Thr Trp Ser Arg Pro Gly Val Ser Ile Trp Tyr Phe Glu Leu 
        195                 200                 205             


Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr Ile Lys Leu 
    210                 215                 220                 


Asp Tyr Arg Ser Tyr Tyr Tyr Ser Ile Gly Asn Leu Lys Pro Asp Thr 
225                 230                 235                 240 


Glu Tyr Glu Val Ser Leu Ile Ser Gly Ser Tyr Gly Leu Val Gly Val 
                245                 250                 255     


Arg Ala Ser Asn Pro Ala Lys Ile Thr Phe Lys Thr Gly Leu 
            260                 265                 270 


<210>  36
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LgBiT_PRSIM_01

<400>  36

Met Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala 
1               5                   10                  15      


Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu 
            20                  25                  30          


Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg 
        35                  40                  45              


Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr 
    50                  55                  60                  


Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys 
65                  70                  75                  80  


Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr 
                85                  90                  95      


Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe 
            100                 105                 110         


Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr 
        115                 120                 125             


Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu 
    130                 135                 140                 


Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly 
145                 150                 155                 160 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gln Val 
                165                 170                 175     


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val 
            180                 185                 190         


Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile 
        195                 200                 205             


Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly 
    210                 215                 220                 


Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly 
225                 230                 235                 240 


Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
                245                 250                 255     


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            260                 265                 270         


Gly Gln Gly Tyr Ile Thr Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser 
305                 310                 315                 320 


Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser 
                325                 330                 335     


Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr 
            340                 345                 350         


Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val 
        355                 360                 365             


Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala 
    370                 375                 380                 


Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala 
385                 390                 395                 400 


Trp Asp His His Trp Glu Gln Val Val Phe Gly Gly Gly Thr Lys Leu 
                405                 410                 415     


Thr Val Leu 
            


<210>  37
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LgBiT_PRSIM_06

<400>  37

Met Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala 
1               5                   10                  15      


Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu 
            20                  25                  30          


Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg 
        35                  40                  45              


Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr 
    50                  55                  60                  


Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys 
65                  70                  75                  80  


Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr 
                85                  90                  95      


Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe 
            100                 105                 110         


Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr 
        115                 120                 125             


Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu 
    130                 135                 140                 


Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly 
145                 150                 155                 160 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gln Val 
                165                 170                 175     


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val 
            180                 185                 190         


Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile 
        195                 200                 205             


Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly 
    210                 215                 220                 


Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly 
225                 230                 235                 240 


Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
                245                 250                 255     


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            260                 265                 270         


Gly Ala Gly Tyr Tyr Met Arg Val Asp Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser 
305                 310                 315                 320 


Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser 
                325                 330                 335     


Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr 
            340                 345                 350         


Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val 
        355                 360                 365             


Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala 
    370                 375                 380                 


Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala 
385                 390                 395                 400 


Trp Asp His Asp Val Glu His Val Val Phe Gly Gly Gly Thr Lys Leu 
                405                 410                 415     


Thr Val Leu 
            


<210>  38
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LgBiT_PRSIM_57

<400>  38

Met Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala 
1               5                   10                  15      


Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu 
            20                  25                  30          


Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg 
        35                  40                  45              


Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr 
    50                  55                  60                  


Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys 
65                  70                  75                  80  


Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr 
                85                  90                  95      


Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe 
            100                 105                 110         


Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr 
        115                 120                 125             


Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu 
    130                 135                 140                 


Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly 
145                 150                 155                 160 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gln Val 
                165                 170                 175     


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val 
            180                 185                 190         


Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile 
        195                 200                 205             


Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly 
    210                 215                 220                 


Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly 
225                 230                 235                 240 


Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
                245                 250                 255     


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            260                 265                 270         


His Thr Asn Tyr Ile Thr Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser 
305                 310                 315                 320 


Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser 
                325                 330                 335     


Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr 
            340                 345                 350         


Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val 
        355                 360                 365             


Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala 
    370                 375                 380                 


Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala 
385                 390                 395                 400 


Trp Asp His His Trp Glu Gln Val Val Phe Gly Gly Gly Thr Lys Leu 
                405                 410                 415     


Thr Val Leu 
            


<210>  39
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LgBiT_PRSIM_67

<400>  39

Met Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala 
1               5                   10                  15      


Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu 
            20                  25                  30          


Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg 
        35                  40                  45              


Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr 
    50                  55                  60                  


Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys 
65                  70                  75                  80  


Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr 
                85                  90                  95      


Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe 
            100                 105                 110         


Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr 
        115                 120                 125             


Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu 
    130                 135                 140                 


Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly 
145                 150                 155                 160 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Glu Val 
                165                 170                 175     


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ala Val 
            180                 185                 190         


Arg Ile Ser Cys Lys Thr Ser Gly Tyr Val Phe Thr Ser Tyr Tyr Val 
        195                 200                 205             


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Val 
    210                 215                 220                 


Ile Asn Pro Ser Gly Gly Asn Thr Asn Tyr Ala Gln Lys Phe Gln Asp 
225                 230                 235                 240 


Arg Val Thr Met Thr Arg Asp Thr Ser Thr Thr Thr Val Tyr Met Glu 
                245                 250                 255     


Leu Ser Ser Leu Met Phe Asp Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
            260                 265                 270         


Arg Asp Tyr Gly Gly Pro Leu Ala Asn Trp Gly Arg Gly Thr Leu Val 
        275                 280                 285             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Ala Leu Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser 
305                 310                 315                 320 


Glu Ala Pro Arg Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser 
                325                 330                 335     


Asn Ile Gly Asn Asn Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys 
            340                 345                 350         


Ala Pro Lys Leu Leu Ile Phe Tyr Asp Asp Leu Leu Pro Ser Gly Val 
        355                 360                 365             


Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala 
    370                 375                 380                 


Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala 
385                 390                 395                 400 


Trp Asp Asp Ser Leu Asn Gly Leu Val Phe Gly Thr Gly Thr Lys Leu 
                405                 410                 415     


Thr Val Leu 
            


<210>  40
<211>  419
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LgBiT_PRSIM_72

<400>  40

Met Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala 
1               5                   10                  15      


Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu 
            20                  25                  30          


Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg 
        35                  40                  45              


Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr 
    50                  55                  60                  


Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys 
65                  70                  75                  80  


Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr 
                85                  90                  95      


Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe 
            100                 105                 110         


Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr 
        115                 120                 125             


Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu 
    130                 135                 140                 


Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly 
145                 150                 155                 160 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gln Val 
                165                 170                 175     


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val 
            180                 185                 190         


Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile 
        195                 200                 205             


Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly 
    210                 215                 220                 


Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly 
225                 230                 235                 240 


Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
                245                 250                 255     


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            260                 265                 270         


Gly Met Ala His Phe Tyr Gln Phe Asp Leu Trp Gly Gln Gly Thr Leu 
        275                 280                 285             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser 
305                 310                 315                 320 


Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser 
                325                 330                 335     


Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr 
            340                 345                 350         


Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val 
        355                 360                 365             


Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala 
    370                 375                 380                 


Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala 
385                 390                 395                 400 


Gly Asp His Asp His Glu His Val Val Phe Gly Gly Gly Thr Lys Leu 
                405                 410                 415     


Thr Val Leu 
            


<210>  41
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LgBiT_PRSIM_75

<400>  41

Met Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala 
1               5                   10                  15      


Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu 
            20                  25                  30          


Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg 
        35                  40                  45              


Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr 
    50                  55                  60                  


Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys 
65                  70                  75                  80  


Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr 
                85                  90                  95      


Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe 
            100                 105                 110         


Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr 
        115                 120                 125             


Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu 
    130                 135                 140                 


Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly 
145                 150                 155                 160 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Glu Val 
                165                 170                 175     


Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val 
            180                 185                 190         


Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Asn Ser Tyr Thr Leu 
        195                 200                 205             


Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly 
    210                 215                 220                 


Ile Ile Pro Val Phe Gly Ser Pro Asn Tyr Gly Gln Lys Phe Gln Gly 
225                 230                 235                 240 


Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
                245                 250                 255     


Leu Ser Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            260                 265                 270         


Gly Leu Val Tyr Gln Pro Leu Asp Ser Trp Gly Arg Gly Thr Leu Val 
        275                 280                 285             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    290                 295                 300                 


Gly Gly Ser Ala Gln Ala Val Leu Thr Gln Pro Ser Ser Ala Ser Gly 
305                 310                 315                 320 


Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn 
                325                 330                 335     


Ile Gly Ser Tyr Thr Val Asn Trp Tyr Gln Gln Phe Pro Gly Thr Ala 
            340                 345                 350         


Pro Lys Leu Leu Ile Tyr Ser Asn Thr Gln Arg Pro Ser Gly Val Pro 
        355                 360                 365             


Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
    370                 375                 380                 


Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp 
385                 390                 395                 400 


Asp Asp Ser Leu Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr 
                405                 410                 415     


Val Leu 
        


<210>  42
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  p65 AD

<400>  42

Asp Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala 
1               5                   10                  15      


Ser Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala 
            20                  25                  30          


Pro Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala 
        35                  40                  45              


Pro Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro 
    50                  55                  60                  


Ala Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu 
65                  70                  75                  80  


Leu Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn 
                85                  90                  95      


Ser Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser 
            100                 105                 110         


Glu Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr 
        115                 120                 125             


Thr Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val 
    130                 135                 140                 


Thr Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala 
145                 150                 155                 160 


Pro Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser 
                165                 170                 175     


Ile Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser Thr 
            180                 185                 190         


Ser Tyr 
        


<210>  43
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZFHD1 DBD (+ leader)

<400>  43

Met Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg Glu Arg 
1               5                   10                  15      


Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser 
            20                  25                  30          


Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe 
        35                  40                  45              


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr 
    50                  55                  60                  


Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg 
65                  70                  75                  80  


Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu 
                85                  90                  95      


Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln 
            100                 105                 110         


Leu Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg 
        115                 120                 125             


Gln Lys Glu Lys Arg Ile Asn Thr 
    130                 135     


<210>  44
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCV-Pro - AD fusion

<400>  44

Met Gly Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu 
1               5                   10                  15      


Ser Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys 
            20                  25                  30          


Gln Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu 
        35                  40                  45              


Val Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile 
    50                  55                  60                  


Asn Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile 
65                  70                  75                  80  


Ala Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys 
                85                  90                  95      


Asp Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro 
            100                 105                 110         


Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp 
        115                 120                 125             


Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser 
    130                 135                 140                 


Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu 
145                 150                 155                 160 


Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr 
                165                 170                 175     


Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu 
            180                 185                 190         


Thr Thr Met Arg Ser Pro 
        195             


<210>  45
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DBD - HCV Pro fusion

<400>  45

Met Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg Glu Arg 
1               5                   10                  15      


Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser 
            20                  25                  30          


Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe 
        35                  40                  45              


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr 
    50                  55                  60                  


Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg 
65                  70                  75                  80  


Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu 
                85                  90                  95      


Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln 
            100                 105                 110         


Leu Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg 
        115                 120                 125             


Gln Lys Glu Lys Arg Ile Asn Thr Ser Ala Gly Ser Arg Leu Asp Ala 
    130                 135                 140                 


Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala Leu Ile 
145                 150                 155                 160 


Thr Trp Val Asp Pro Arg Tyr Asp Asp Ile Trp Trp Phe Glu Leu Thr 
                165                 170                 175     


Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr Ile Lys Leu Tyr 
            180                 185                 190         


Leu Asn Asp Pro Tyr Tyr Ser Ile Gly Asn Leu Lys Pro Asp Thr Glu 
        195                 200                 205             


Tyr Glu Val Ser Leu Ile Ser Tyr Thr Gly Asp Ser Tyr Ser Arg Ser 
    210                 215                 220                 


Gly Ser Asn Pro Ala Lys Ile Thr Phe Lys Thr Gly Leu 
225                 230                 235         


<210>  46
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_23_DBD_fusion

<400>  46

Met Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg Glu Arg 
1               5                   10                  15      


Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser 
            20                  25                  30          


Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe 
        35                  40                  45              


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr 
    50                  55                  60                  


Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg 
65                  70                  75                  80  


Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu 
                85                  90                  95      


Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln 
            100                 105                 110         


Leu Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg 
        115                 120                 125             


Gln Lys Glu Lys Arg Ile Asn Thr Ser Ala Gly Ser Arg Leu Asp Ala 
    130                 135                 140                 


Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala Leu Ile 
145                 150                 155                 160 


Thr Trp Val Asp Pro Arg Tyr Asp Asp Ile Trp Trp Phe Glu Leu Thr 
                165                 170                 175     


Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr Ile Lys Leu Tyr 
            180                 185                 190         


Leu Asn Asp Pro Tyr Tyr Ser Ile Gly Asn Leu Lys Pro Asp Thr Glu 
        195                 200                 205             


Tyr Glu Val Ser Leu Ile Ser Tyr Thr Gly Asp Ser Tyr Ser Arg Ser 
    210                 215                 220                 


Gly Ser Asn Pro Ala Lys Ile Thr Phe Lys Thr Gly Leu 
225                 230                 235         


<210>  47
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_32_DBD_fusion

<400>  47

Met Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg Glu Arg 
1               5                   10                  15      


Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser 
            20                  25                  30          


Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe 
        35                  40                  45              


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr 
    50                  55                  60                  


Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg 
65                  70                  75                  80  


Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu 
                85                  90                  95      


Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln 
            100                 105                 110         


Leu Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg 
        115                 120                 125             


Gln Lys Glu Lys Arg Ile Asn Thr Ser Ala Gly Ser Arg Leu Asp Ala 
    130                 135                 140                 


Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala Leu Ile 
145                 150                 155                 160 


Thr Trp Trp Ser Pro Arg Tyr Tyr Tyr Ala Ser Ile Ser Gly Phe Glu 
                165                 170                 175     


Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr Ile Lys 
            180                 185                 190         


Leu Asp Tyr Ala Ser Asn Asp Tyr Ser Ile Gly Asn Leu Lys Pro Asp 
        195                 200                 205             


Thr Glu Tyr Glu Val Ser Leu Ile Ser Trp Asn Tyr Gly Asp Trp Arg 
    210                 215                 220                 


Tyr Ser Ser Ser Asn Pro Ala Lys Ile Thr Phe Lys Thr Gly Leu 
225                 230                 235                 


<210>  48
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_33_DBD_fusion

<400>  48

Met Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg Glu Arg 
1               5                   10                  15      


Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser 
            20                  25                  30          


Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe 
        35                  40                  45              


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr 
    50                  55                  60                  


Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg 
65                  70                  75                  80  


Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu 
                85                  90                  95      


Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln 
            100                 105                 110         


Leu Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg 
        115                 120                 125             


Gln Lys Glu Lys Arg Ile Asn Thr Ser Ala Gly Ser Arg Leu Asp Ala 
    130                 135                 140                 


Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala Leu Ile 
145                 150                 155                 160 


Thr Trp Tyr Pro Pro Gly Arg Trp Tyr Asp Asp Ile Trp Tyr Phe Glu 
                165                 170                 175     


Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr Ile Lys 
            180                 185                 190         


Leu Ala Arg Gly Asp Asp Val Tyr Ser Ile Gly Asn Leu Lys Pro Asp 
        195                 200                 205             


Thr Glu Tyr Glu Val Ser Leu Ile Ser Trp Gly Pro Asp Arg Gly Asp 
    210                 215                 220                 


Arg Ala Gly Ser Asn Pro Ala Lys Ile Thr Phe Lys Thr Gly Leu 
225                 230                 235                 


<210>  49
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_36_DBD_fusion

<400>  49

Met Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg Glu Arg 
1               5                   10                  15      


Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser 
            20                  25                  30          


Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe 
        35                  40                  45              


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr 
    50                  55                  60                  


Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg 
65                  70                  75                  80  


Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu 
                85                  90                  95      


Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln 
            100                 105                 110         


Leu Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg 
        115                 120                 125             


Gln Lys Glu Lys Arg Ile Asn Thr Ser Ala Gly Ser Arg Leu Asp Ala 
    130                 135                 140                 


Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala Leu Ile 
145                 150                 155                 160 


Thr Trp Ser Trp Pro Arg Asp Asp Asp Tyr Asp Ile Trp Tyr Phe Glu 
                165                 170                 175     


Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr Ile Lys 
            180                 185                 190         


Leu Leu Asn Tyr Ala Ser Pro Tyr Ser Ile Gly Asn Leu Lys Pro Asp 
        195                 200                 205             


Thr Glu Tyr Glu Val Ser Leu Ile Ser Val Val Pro Asp Thr Tyr Gly 
    210                 215                 220                 


Arg Gly Thr Ser Asn Pro Ala Lys Ile Thr Phe Lys Thr Gly Leu 
225                 230                 235                 


<210>  50
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_47_DBD_fusion

<400>  50

Met Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg Glu Arg 
1               5                   10                  15      


Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser 
            20                  25                  30          


Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe 
        35                  40                  45              


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr 
    50                  55                  60                  


Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg 
65                  70                  75                  80  


Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu 
                85                  90                  95      


Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln 
            100                 105                 110         


Leu Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg 
        115                 120                 125             


Gln Lys Glu Lys Arg Ile Asn Thr Ser Ala Gly Ser Arg Leu Asp Ala 
    130                 135                 140                 


Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala Leu Ile 
145                 150                 155                 160 


Thr Trp Ser Arg Pro Gly Val Ser Ile Trp Tyr Phe Glu Leu Thr Tyr 
                165                 170                 175     


Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr Ile Lys Leu Asp Tyr 
            180                 185                 190         


Arg Ser Tyr Tyr Tyr Ser Ile Gly Asn Leu Lys Pro Asp Thr Glu Tyr 
        195                 200                 205             


Glu Val Ser Leu Ile Ser Gly Ser Tyr Gly Leu Val Gly Val Arg Ala 
    210                 215                 220                 


Ser Asn Pro Ala Lys Ile Thr Phe Lys Thr Gly Leu 
225                 230                 235     


<210>  51
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_01_DBD_fusion

<400>  51

Met Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg Glu Arg 
1               5                   10                  15      


Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser 
            20                  25                  30          


Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe 
        35                  40                  45              


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr 
    50                  55                  60                  


Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg 
65                  70                  75                  80  


Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu 
                85                  90                  95      


Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln 
            100                 105                 110         


Leu Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg 
        115                 120                 125             


Gln Lys Glu Lys Arg Ile Asn Thr Ser Ala Gly Ser Gln Val Gln Leu 
    130                 135                 140                 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
145                 150                 155                 160 


Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp 
                165                 170                 175     


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile 
            180                 185                 190         


Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val 
        195                 200                 205             


Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
    210                 215                 220                 


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gln 
225                 230                 235                 240 


Gly Tyr Ile Thr Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr 
        275                 280                 285             


Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile 
    290                 295                 300                 


Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro 
305                 310                 315                 320 


Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp 
                325                 330                 335     


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
            340                 345                 350         


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
        355                 360                 365             


His His Trp Glu Gln Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
    370                 375                 380                 


Leu 
385 


<210>  52
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_04_DBD_fusion

<400>  52

Met Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg Glu Arg 
1               5                   10                  15      


Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser 
            20                  25                  30          


Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe 
        35                  40                  45              


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr 
    50                  55                  60                  


Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg 
65                  70                  75                  80  


Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu 
                85                  90                  95      


Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln 
            100                 105                 110         


Leu Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg 
        115                 120                 125             


Gln Lys Glu Lys Arg Ile Asn Thr Ser Ala Gly Ser Gln Val Gln Leu 
    130                 135                 140                 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
145                 150                 155                 160 


Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp 
                165                 170                 175     


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile 
            180                 185                 190         


Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val 
        195                 200                 205             


Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
    210                 215                 220                 


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Met 
225                 230                 235                 240 


Ala His Phe Tyr Gln Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr 
        275                 280                 285             


Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile 
    290                 295                 300                 


Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro 
305                 310                 315                 320 


Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp 
                325                 330                 335     


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
            340                 345                 350         


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Gly Asp 
        355                 360                 365             


His Asp His Glu His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
    370                 375                 380                 


Leu 
385 


<210>  53
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_57_DBD_fusion

<400>  53

Met Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg Glu Arg 
1               5                   10                  15      


Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser 
            20                  25                  30          


Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe 
        35                  40                  45              


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr 
    50                  55                  60                  


Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg 
65                  70                  75                  80  


Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu 
                85                  90                  95      


Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln 
            100                 105                 110         


Leu Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg 
        115                 120                 125             


Gln Lys Glu Lys Arg Ile Asn Thr Ser Ala Gly Ser Gln Val Gln Leu 
    130                 135                 140                 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
145                 150                 155                 160 


Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp 
                165                 170                 175     


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile 
            180                 185                 190         


Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val 
        195                 200                 205             


Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
    210                 215                 220                 


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Thr 
225                 230                 235                 240 


Asn Tyr Ile Thr Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr 
        275                 280                 285             


Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile 
    290                 295                 300                 


Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro 
305                 310                 315                 320 


Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp 
                325                 330                 335     


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
            340                 345                 350         


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
        355                 360                 365             


His His Trp Glu Gln Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
    370                 375                 380                 


Leu 
385 


<210>  54
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_67_DBD_fusion

<400>  54

Met Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg Glu Arg 
1               5                   10                  15      


Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser 
            20                  25                  30          


Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe 
        35                  40                  45              


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr 
    50                  55                  60                  


Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg 
65                  70                  75                  80  


Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu 
                85                  90                  95      


Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln 
            100                 105                 110         


Leu Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg 
        115                 120                 125             


Gln Lys Glu Lys Arg Ile Asn Thr Ser Ala Gly Ser Glu Val Gln Leu 
    130                 135                 140                 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ala Val Arg Ile 
145                 150                 155                 160 


Ser Cys Lys Thr Ser Gly Tyr Val Phe Thr Ser Tyr Tyr Val His Trp 
                165                 170                 175     


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Val Ile Asn 
            180                 185                 190         


Pro Ser Gly Gly Asn Thr Asn Tyr Ala Gln Lys Phe Gln Asp Arg Val 
        195                 200                 205             


Thr Met Thr Arg Asp Thr Ser Thr Thr Thr Val Tyr Met Glu Leu Ser 
    210                 215                 220                 


Ser Leu Met Phe Asp Asp Thr Ala Val Tyr Tyr Cys Ala Lys Arg Asp 
225                 230                 235                 240 


Tyr Gly Gly Pro Leu Ala Asn Trp Gly Arg Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Ala Leu Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Glu Ala 
        275                 280                 285             


Pro Arg Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile 
    290                 295                 300                 


Gly Asn Asn Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro 
305                 310                 315                 320 


Lys Leu Leu Ile Phe Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp 
                325                 330                 335     


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
            340                 345                 350         


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp 
        355                 360                 365             


Asp Ser Leu Asn Gly Leu Val Phe Gly Thr Gly Thr Lys Leu Thr Val 
    370                 375                 380                 


Leu 
385 


<210>  55
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_72_DBD_fusion

<400>  55

Met Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg Glu Arg 
1               5                   10                  15      


Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser 
            20                  25                  30          


Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe 
        35                  40                  45              


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr 
    50                  55                  60                  


Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg 
65                  70                  75                  80  


Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu 
                85                  90                  95      


Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln 
            100                 105                 110         


Leu Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg 
        115                 120                 125             


Gln Lys Glu Lys Arg Ile Asn Thr Ser Ala Gly Ser Gln Val Gln Leu 
    130                 135                 140                 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
145                 150                 155                 160 


Ser Cys Lys Val Ser Gly Gly Ser Phe Asn Asn Tyr Gly Val Ser Trp 
                165                 170                 175     


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg Ile Ile 
            180                 185                 190         


Pro Ile Arg Asp Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val 
        195                 200                 205             


Thr Ile Thr Ala Asp Thr Ser Thr Asn Ile Ala Tyr Met Glu Leu Ser 
    210                 215                 220                 


Gly Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Leu 
225                 230                 235                 240 


Glu Asp Asp Phe Trp Gly Gly Tyr Tyr Asp Phe Tyr Phe Tyr Val Met 
                245                 250                 255     


Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Ser Ser 
        275                 280                 285             


Glu Leu Thr Gln Asp Pro Val Val Ser Val Pro Leu Gly Gln Thr Ala 
    290                 295                 300                 


Arg Ile Thr Cys Gln Gly Asp Ser Leu Thr Thr Tyr Tyr Ala Thr Trp 
305                 310                 315                 320 


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Leu Tyr Asn Glu 
                325                 330                 335     


His Lys Arg Pro Ser Gly Ile Ser Asp Arg Phe Ser Gly Ser Ser Ala 
            340                 345                 350         


Gly Asp Ala Ala Ser Leu Thr Ile Thr Asp Thr Gln Ala Glu Asp Glu 
        355                 360                 365             


Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Thr Gly Gly Lys His Val Leu 
    370                 375                 380                 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
385                 390                 


<210>  56
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_75_DBD_fusion

<400>  56

Met Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg Glu Arg 
1               5                   10                  15      


Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser 
            20                  25                  30          


Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe 
        35                  40                  45              


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr 
    50                  55                  60                  


Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg 
65                  70                  75                  80  


Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu 
                85                  90                  95      


Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln 
            100                 105                 110         


Leu Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg 
        115                 120                 125             


Gln Lys Glu Lys Arg Ile Asn Thr Ser Ala Gly Ser Glu Val Gln Leu 
    130                 135                 140                 


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val 
145                 150                 155                 160 


Ser Cys Lys Ala Ser Gly Gly Ser Phe Asn Ser Tyr Thr Leu Asp Trp 
                165                 170                 175     


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Gly Ile Ile 
            180                 185                 190         


Pro Val Phe Gly Ser Pro Asn Tyr Gly Gln Lys Phe Gln Gly Arg Val 
        195                 200                 205             


Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser 
    210                 215                 220                 


Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Leu 
225                 230                 235                 240 


Val Tyr Gln Pro Leu Asp Ser Trp Gly Arg Gly Thr Leu Val Thr Val 
                245                 250                 255     


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Ala Gln Ala Val Leu Thr Gln Pro Ser Ser Ala Ser Gly Thr Pro 
        275                 280                 285             


Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly 
    290                 295                 300                 


Ser Tyr Thr Val Asn Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys 
305                 310                 315                 320 


Leu Leu Ile Tyr Ser Asn Thr Gln Arg Pro Ser Gly Val Pro Asp Arg 
                325                 330                 335     


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
            340                 345                 350         


Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp 
        355                 360                 365             


Ser Leu Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
    370                 375                 380                 


<210>  57
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_23_AD_fusion

<400>  57

Met Gly Ser Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val 
1               5                   10                  15      


Thr Asp Thr Thr Ala Leu Ile Thr Trp Val Asp Pro Arg Tyr Asp Asp 
            20                  25                  30          


Ile Trp Trp Phe Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp 
        35                  40                  45              


Arg Thr Thr Ile Lys Leu Tyr Leu Asn Asp Pro Tyr Tyr Ser Ile Gly 
    50                  55                  60                  


Asn Leu Lys Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Tyr Thr 
65                  70                  75                  80  


Gly Asp Ser Tyr Ser Arg Ser Gly Ser Asn Pro Ala Lys Ile Thr Phe 
                85                  90                  95      


Lys Thr Gly Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
            100                 105                 110         


Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser 
        115                 120                 125             


Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro 
    130                 135                 140                 


Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro 
145                 150                 155                 160 


Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala 
                165                 170                 175     


Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu 
            180                 185                 190         


Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser 
        195                 200                 205             


Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu 
    210                 215                 220                 


Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr 
225                 230                 235                 240 


Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr 
                245                 250                 255     


Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro 
            260                 265                 270         


Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile 
        275                 280                 285             


Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser Thr Ser 
    290                 295                 300                 


Tyr 
305 


<210>  58
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_32_AD_fusion

<400>  58

Met Gly Ser Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val 
1               5                   10                  15      


Thr Asp Thr Thr Ala Leu Ile Thr Trp Trp Ser Pro Arg Tyr Tyr Tyr 
            20                  25                  30          


Ala Ser Ile Ser Gly Phe Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro 
        35                  40                  45              


Gly Asp Arg Thr Thr Ile Lys Leu Asp Tyr Ala Ser Asn Asp Tyr Ser 
    50                  55                  60                  


Ile Gly Asn Leu Lys Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser 
65                  70                  75                  80  


Trp Asn Tyr Gly Asp Trp Arg Tyr Ser Ser Ser Asn Pro Ala Lys Ile 
                85                  90                  95      


Thr Phe Lys Thr Gly Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            100                 105                 110         


Ser Asp Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln 
        115                 120                 125             


Ala Ser Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro 
    130                 135                 140                 


Ala Pro Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro 
145                 150                 155                 160 


Ala Pro Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro 
                165                 170                 175     


Pro Ala Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala 
            180                 185                 190         


Leu Leu Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly 
        195                 200                 205             


Asn Ser Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn 
    210                 215                 220                 


Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His 
225                 230                 235                 240 


Thr Thr Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu 
                245                 250                 255     


Val Thr Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly 
            260                 265                 270         


Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser 
        275                 280                 285             


Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser 
    290                 295                 300                 


Thr Ser Tyr 
305         


<210>  59
<211>  307
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_33_AD_fusion

<400>  59

Met Gly Ser Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val 
1               5                   10                  15      


Thr Asp Thr Thr Ala Leu Ile Thr Trp Tyr Pro Pro Gly Arg Trp Tyr 
            20                  25                  30          


Asp Asp Ile Trp Tyr Phe Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro 
        35                  40                  45              


Gly Asp Arg Thr Thr Ile Lys Leu Ala Arg Gly Asp Asp Val Tyr Ser 
    50                  55                  60                  


Ile Gly Asn Leu Lys Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser 
65                  70                  75                  80  


Trp Gly Pro Asp Arg Gly Asp Arg Ala Gly Ser Asn Pro Ala Lys Ile 
                85                  90                  95      


Thr Phe Lys Thr Gly Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            100                 105                 110         


Ser Asp Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln 
        115                 120                 125             


Ala Ser Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro 
    130                 135                 140                 


Ala Pro Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro 
145                 150                 155                 160 


Ala Pro Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro 
                165                 170                 175     


Pro Ala Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala 
            180                 185                 190         


Leu Leu Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly 
        195                 200                 205             


Asn Ser Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn 
    210                 215                 220                 


Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His 
225                 230                 235                 240 


Thr Thr Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu 
                245                 250                 255     


Val Thr Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly 
            260                 265                 270         


Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser 
        275                 280                 285             


Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser 
    290                 295                 300                 


Thr Ser Tyr 
305         


<210>  60
<211>  307
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_36_AD_fusion

<400>  60

Met Gly Ser Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val 
1               5                   10                  15      


Thr Asp Thr Thr Ala Leu Ile Thr Trp Ser Trp Pro Arg Asp Asp Asp 
            20                  25                  30          


Tyr Asp Ile Trp Tyr Phe Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro 
        35                  40                  45              


Gly Asp Arg Thr Thr Ile Lys Leu Leu Asn Tyr Ala Ser Pro Tyr Ser 
    50                  55                  60                  


Ile Gly Asn Leu Lys Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser 
65                  70                  75                  80  


Val Val Pro Asp Thr Tyr Gly Arg Gly Thr Ser Asn Pro Ala Lys Ile 
                85                  90                  95      


Thr Phe Lys Thr Gly Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            100                 105                 110         


Ser Asp Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln 
        115                 120                 125             


Ala Ser Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro 
    130                 135                 140                 


Ala Pro Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro 
145                 150                 155                 160 


Ala Pro Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro 
                165                 170                 175     


Pro Ala Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala 
            180                 185                 190         


Leu Leu Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly 
        195                 200                 205             


Asn Ser Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn 
    210                 215                 220                 


Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His 
225                 230                 235                 240 


Thr Thr Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu 
                245                 250                 255     


Val Thr Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly 
            260                 265                 270         


Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser 
        275                 280                 285             


Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser 
    290                 295                 300                 


Thr Ser Tyr 
305         


<210>  61
<211>  304
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_47_AD_fusion

<400>  61

Met Gly Ser Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val 
1               5                   10                  15      


Thr Asp Thr Thr Ala Leu Ile Thr Trp Ser Arg Pro Gly Val Ser Ile 
            20                  25                  30          


Trp Tyr Phe Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg 
        35                  40                  45              


Thr Thr Ile Lys Leu Asp Tyr Arg Ser Tyr Tyr Tyr Ser Ile Gly Asn 
    50                  55                  60                  


Leu Lys Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Gly Ser Tyr 
65                  70                  75                  80  


Gly Leu Val Gly Val Arg Ala Ser Asn Pro Ala Lys Ile Thr Phe Lys 
                85                  90                  95      


Thr Gly Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Glu 
            100                 105                 110         


Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala 
        115                 120                 125             


Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala 
    130                 135                 140                 


Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val 
145                 150                 155                 160 


Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro 
                165                 170                 175     


Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln 
            180                 185                 190         


Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr 
        195                 200                 205             


Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe 
    210                 215                 220                 


Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu 
225                 230                 235                 240 


Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly 
                245                 250                 255     


Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly 
            260                 265                 270         


Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala 
        275                 280                 285             


Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser Thr Ser Tyr 
    290                 295                 300                 


<210>  62
<211>  453
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_01_AD_fusion

<400>  62

Met Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
1               5                   10                  15      


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
            20                  25                  30          


Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
        35                  40                  45              


Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala 
    50                  55                  60                  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser 
65                  70                  75                  80  


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Gln Gly Tyr Tyr Gly Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys 
145                 150                 155                 160 


Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln 
                165                 170                 175     


Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Val Ser Lys Ser Gly Thr 
        195                 200                 205             


Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Ala Trp Asp His Gly His Glu His Val Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu Thr Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Asp Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile 
            260                 265                 270         


Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln 
        275                 280                 285             


Ala Pro Ala Pro Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln 
    290                 295                 300                 


Ala Pro Ala Pro Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val 
305                 310                 315                 320 


Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser 
                325                 330                 335     


Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu 
            340                 345                 350         


Leu Gly Asn Ser Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val 
        355                 360                 365             


Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala 
    370                 375                 380                 


Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr 
385                 390                 395                 400 


Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro 
                405                 410                 415     


Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp 
            420                 425                 430         


Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile 
        435                 440                 445             


Ser Ser Thr Ser Tyr 
    450             


<210>  63
<211>  453
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_04_AD_fusion

<400>  63

Met Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
1               5                   10                  15      


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
            20                  25                  30          


Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
        35                  40                  45              


Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala 
    50                  55                  60                  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser 
65                  70                  75                  80  


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Met Ala His Phe Tyr Gln Phe Asp Leu Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys 
145                 150                 155                 160 


Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln 
                165                 170                 175     


Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr 
        195                 200                 205             


Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Ala Gly Asp His Asp His Glu His Val Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu Thr Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Asp Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile 
            260                 265                 270         


Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln 
        275                 280                 285             


Ala Pro Ala Pro Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln 
    290                 295                 300                 


Ala Pro Ala Pro Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val 
305                 310                 315                 320 


Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser 
                325                 330                 335     


Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu 
            340                 345                 350         


Leu Gly Asn Ser Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val 
        355                 360                 365             


Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala 
    370                 375                 380                 


Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr 
385                 390                 395                 400 


Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro 
                405                 410                 415     


Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp 
            420                 425                 430         


Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile 
        435                 440                 445             


Ser Ser Thr Ser Tyr 
    450             


<210>  64
<211>  453
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_57_AD_fusion

<400>  64

Met Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
1               5                   10                  15      


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
            20                  25                  30          


Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
        35                  40                  45              


Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala 
    50                  55                  60                  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser 
65                  70                  75                  80  


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg His Thr Asn Tyr Ile Thr Val Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys 
145                 150                 155                 160 


Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln 
                165                 170                 175     


Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr 
        195                 200                 205             


Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Ala Trp Asp His His Trp Glu Gln Val Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu Thr Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Asp Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile 
            260                 265                 270         


Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln 
        275                 280                 285             


Ala Pro Ala Pro Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln 
    290                 295                 300                 


Ala Pro Ala Pro Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val 
305                 310                 315                 320 


Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser 
                325                 330                 335     


Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu 
            340                 345                 350         


Leu Gly Asn Ser Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val 
        355                 360                 365             


Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala 
    370                 375                 380                 


Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr 
385                 390                 395                 400 


Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro 
                405                 410                 415     


Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp 
            420                 425                 430         


Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile 
        435                 440                 445             


Ser Ser Thr Ser Tyr 
    450             


<210>  65
<211>  453
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_67_AD_fusion

<400>  65

Met Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
1               5                   10                  15      


Pro Gly Ala Ala Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Val Phe 
            20                  25                  30          


Thr Ser Tyr Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
        35                  40                  45              


Glu Trp Met Gly Val Ile Asn Pro Ser Gly Gly Asn Thr Asn Tyr Ala 
    50                  55                  60                  


Gln Lys Phe Gln Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Thr 
65                  70                  75                  80  


Thr Val Tyr Met Glu Leu Ser Ser Leu Met Phe Asp Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Lys Arg Asp Tyr Gly Gly Pro Leu Ala Asn Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Leu Ser Tyr Glu Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Val Ser Glu Ala Pro Arg Gln Arg Val Thr Ile Ser Cys 
145                 150                 155                 160 


Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn Trp Tyr Gln 
                165                 170                 175     


Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu Ile Phe Tyr Asp Asp Leu 
            180                 185                 190         


Leu Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr 
        195                 200                 205             


Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Leu Val Phe Gly 
225                 230                 235                 240 


Thr Gly Thr Lys Leu Thr Val Leu Thr Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Asp Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile 
            260                 265                 270         


Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln 
        275                 280                 285             


Ala Pro Ala Pro Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln 
    290                 295                 300                 


Ala Pro Ala Pro Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val 
305                 310                 315                 320 


Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser 
                325                 330                 335     


Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu 
            340                 345                 350         


Leu Gly Asn Ser Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val 
        355                 360                 365             


Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala 
    370                 375                 380                 


Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr 
385                 390                 395                 400 


Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro 
                405                 410                 415     


Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp 
            420                 425                 430         


Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile 
        435                 440                 445             


Ser Ser Thr Ser Tyr 
    450             


<210>  66
<211>  462
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_72_AD_fusion

<400>  66

Met Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
1               5                   10                  15      


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Ser Phe 
            20                  25                  30          


Asn Asn Tyr Gly Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
        35                  40                  45              


Glu Trp Met Gly Arg Ile Ile Pro Ile Arg Asp Thr Ala Asn Tyr Ala 
    50                  55                  60                  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn 
65                  70                  75                  80  


Ile Ala Tyr Met Glu Leu Ser Gly Leu Arg Ser Asp Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Val Leu Glu Asp Asp Phe Trp Gly Gly Tyr Tyr 
            100                 105                 110         


Asp Phe Tyr Phe Tyr Val Met Asp Val Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Ala Leu Ser Ser Glu Leu Thr Gln Asp Pro Val Val Ser 
145                 150                 155                 160 


Val Pro Leu Gly Gln Thr Ala Arg Ile Thr Cys Gln Gly Asp Ser Leu 
                165                 170                 175     


Thr Thr Tyr Tyr Ala Thr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
            180                 185                 190         


Val Leu Val Leu Tyr Asn Glu His Lys Arg Pro Ser Gly Ile Ser Asp 
        195                 200                 205             


Arg Phe Ser Gly Ser Ser Ala Gly Asp Ala Ala Ser Leu Thr Ile Thr 
    210                 215                 220                 


Asp Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp 
225                 230                 235                 240 


Thr Gly Gly Lys His Val Leu Phe Gly Gly Gly Thr Lys Leu Thr Val 
                245                 250                 255     


Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Glu Phe Pro 
            260                 265                 270         


Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala 
        275                 280                 285             


Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala 
    290                 295                 300                 


Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val 
305                 310                 315                 320 


Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro 
                325                 330                 335     


Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln 
            340                 345                 350         


Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro 
        355                 360                 365             


Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln 
    370                 375                 380                 


Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro Met 
385                 390                 395                 400 


Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln 
                405                 410                 415     


Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro 
            420                 425                 430         


Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met 
        435                 440                 445             


Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser Thr Ser Tyr 
    450                 455                 460         


<210>  67
<211>  452
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_75_AD_fusion

<400>  67

Met Gly Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
1               5                   10                  15      


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Phe 
            20                  25                  30          


Asn Ser Tyr Thr Leu Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
        35                  40                  45              


Glu Trp Met Gly Gly Ile Ile Pro Val Phe Gly Ser Pro Asn Tyr Gly 
    50                  55                  60                  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser 
65                  70                  75                  80  


Thr Ala Tyr Met Glu Leu Ser Ser Leu Lys Ser Asp Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Gly Leu Val Tyr Gln Pro Leu Asp Ser Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ala Val Leu Thr Gln Pro 
    130                 135                 140                 


Ser Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser 
145                 150                 155                 160 


Gly Ser Ser Ser Asn Ile Gly Ser Tyr Thr Val Asn Trp Tyr Gln Gln 
                165                 170                 175     


Phe Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Thr Gln Arg 
            180                 185                 190         


Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser 
        195                 200                 205             


Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Thr Val Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Asp Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser 
            260                 265                 270         


Gln Ala Ser Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala 
        275                 280                 285             


Pro Ala Pro Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala 
    290                 295                 300                 


Pro Ala Pro Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala 
305                 310                 315                 320 


Pro Pro Ala Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu 
                325                 330                 335     


Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu 
            340                 345                 350         


Gly Asn Ser Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp 
        355                 360                 365             


Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro 
    370                 375                 380                 


His Thr Thr Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg 
385                 390                 395                 400 


Leu Val Thr Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu 
                405                 410                 415     


Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe 
            420                 425                 430         


Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser 
        435                 440                 445             


Ser Thr Ser Tyr 
    450         


<210>  68
<211>  212
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NanoLuc-Pest

<400>  68

Met Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln Thr Ala 
1               5                   10                  15      


Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu 
            20                  25                  30          


Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile Val Leu 
        35                  40                  45              


Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr 
    50                  55                  60                  


Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile Phe Lys 
65                  70                  75                  80  


Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu His Tyr 
                85                  90                  95      


Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp Tyr Phe 
            100                 105                 110         


Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr 
        115                 120                 125             


Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu 
    130                 135                 140                 


Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn Gly Val 
145                 150                 155                 160 


Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Asn Ser His Gly Phe 
                165                 170                 175     


Pro Pro Glu Val Glu Glu Gln Ala Ala Gly Thr Leu Pro Met Ser Cys 
            180                 185                 190         


Ala Gln Glu Ser Gly Met Asp Arg His Pro Ala Ala Cys Ala Ser Ala 
        195                 200                 205             


Arg Ile Asn Val 
    210         


<210>  69
<211>  864
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FKBP12:FRB CAR

<400>  69

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
            20                  25                  30          


Cys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
        35                  40                  45              


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly 
    50                  55                  60                  


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
65                  70                  75                  80  


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
                85                  90                  95      


Glu Glu Gly Gly Cys Glu Leu Ser Arg Gly Ser Gly Ser Gly Ser Gly 
            100                 105                 110         


Ser Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr 
        115                 120                 125             


Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu 
    130                 135                 140                 


Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe 
145                 150                 155                 160 


Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly 
                165                 170                 175     


Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro 
            180                 185                 190         


Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His 
        195                 200                 205             


Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Ser Gly 
    210                 215                 220                 


Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
225                 230                 235                 240 


Pro Gly Pro Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu 
                245                 250                 255     


Pro Val Ala Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro 
            260                 265                 270         


Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu 
        275                 280                 285             


Ser Leu Pro Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Phe 
    290                 295                 300                 


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
305                 310                 315                 320 


Val Thr Val Ala Phe Ile Ile Phe Trp Val Ser Leu Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Ile Leu Trp His Glu Met Trp His Glu Gly 
    370                 375                 380                 


Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly 
385                 390                 395                 400 


Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro 
                405                 410                 415     


Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu 
            420                 425                 430         


Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val 
        435                 440                 445             


Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg 
    450                 455                 460                 


Ile Ser Lys Gly Ser Gly Ser Gly Ser Gly Ser Ser Leu Arg Val Lys 
465                 470                 475                 480 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
                485                 490                 495     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            500                 505                 510         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        515                 520                 525             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    530                 535                 540                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
545                 550                 555                 560 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                565                 570                 575     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly 
            580                 585                 590         


Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
        595                 600                 605             


Gly Pro Ser Gly Met Glu Ser Asp Glu Ser Gly Leu Pro Ala Met Glu 
    610                 615                 620                 


Ile Glu Cys Arg Ile Thr Gly Thr Leu Asn Gly Val Glu Phe Glu Leu 
625                 630                 635                 640 


Val Gly Gly Gly Glu Gly Thr Pro Lys Gln Gly Arg Met Thr Asn Lys 
                645                 650                 655     


Met Lys Ser Thr Lys Gly Ala Leu Thr Phe Ser Pro Tyr Leu Leu Ser 
            660                 665                 670         


His Val Met Gly Tyr Gly Phe Tyr His Phe Gly Thr Tyr Pro Ser Gly 
        675                 680                 685             


Tyr Glu Asn Pro Phe Leu His Ala Ile Asn Asn Gly Gly Tyr Thr Asn 
    690                 695                 700                 


Thr Arg Ile Glu Lys Tyr Glu Asp Gly Gly Val Leu His Val Ser Phe 
705                 710                 715                 720 


Ser Tyr Arg Tyr Glu Ala Gly Arg Val Ile Gly Asp Phe Lys Val Val 
                725                 730                 735     


Gly Thr Gly Phe Pro Glu Asp Ser Val Ile Phe Thr Asp Lys Ile Ile 
            740                 745                 750         


Arg Ser Asn Ala Thr Val Glu His Leu His Pro Met Gly Asp Asn Val 
        755                 760                 765             


Leu Val Gly Ser Phe Ala Arg Thr Phe Ser Leu Arg Asp Gly Gly Tyr 
    770                 775                 780                 


Tyr Ser Phe Val Val Asp Ser His Met His Phe Lys Ser Ala Ile His 
785                 790                 795                 800 


Pro Ser Ile Leu Gln Asn Gly Gly Pro Met Phe Ala Phe Arg Arg Val 
                805                 810                 815     


Glu Glu Leu His Ser Asn Thr Glu Leu Gly Ile Val Glu Tyr Gln His 
            820                 825                 830         


Ala Phe Lys Thr Pro Ile Ala Phe Ala Arg Ser Arg Ala Gln Ser Ser 
        835                 840                 845             


Asn Ser Ala Val Asp Gly Thr Ala Gly Pro Gly Ser Thr Gly Ser Arg 
    850                 855                 860                 


<210>  70
<211>  291
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_23 CAR 1st polypeptide

<400>  70

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Phe Trp Val Leu 
1               5                   10                  15      


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
            20                  25                  30          


Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        35                  40                  45              


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    50                  55                  60                  


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
65                  70                  75                  80  


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Lys Lys Lys Gly 
                85                  90                  95      


Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser Gly Asp Thr Ala Tyr 
            100                 105                 110         


Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys Gln Glu Thr Ser Gln Thr 
        115                 120                 125             


Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val Gln Ile Val Ser Thr 
    130                 135                 140                 


Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile Asn Gly Val Leu Trp Thr 
145                 150                 155                 160 


Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro 
                165                 170                 175     


Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp Leu Val Gly Trp Gln 
            180                 185                 190         


Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser 
        195                 200                 205             


Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg 
    210                 215                 220                 


Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr 
225                 230                 235                 240 


Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala 
                245                 250                 255     


Val Gly Ile Phe Arg Ala Ala Val Ser Thr Arg Gly Val Ala Lys Ala 
            260                 265                 270         


Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr Thr Met Arg Ser Pro 
        275                 280                 285             


Gly Ser Gly 
    290     


<210>  71
<211>  687
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Wild-type HCV NS3/4A PR with N-terminal 6His and AviTag

<400>  71
atgggtagca gccatcacca tcatcatcat ggtagcggtc tgaacgatat ttttgaagcc       60

cagaaaatcg aatggcatga aggtggtggt ggtagcatga aaaaaaaggg tagcgttgtt      120

attgtgggtc gcattaatct gagcggtgat accgcatatg cacagcagac ccgtggtgaa      180

gaaggttgtc aagaaaccag ccagaccggt cgtgataaaa atcaggttga aggtgaagtt      240

cagattgtta gcaccgcaac acagaccttt ctggcaacca gcattaatgg tgttctgtgg      300

accgtttatc atggtgcagg cacccgtacc attgcaagcc cgaaaggtcc ggttacacag      360

atgtatacca atgtggataa agatctggtt ggttggcagg caccgcaggg tagccgtagt      420

ctgaccccgt gtacctgtgg tagcagcgat ctgtatctgg ttacccgtca tgcagatgtt      480

attccggttc gtcgtcgtgg tgatagccgt ggtagcctgc tgagtccgcg tccgattagc      540

tatctgaaag gtagcagtgg tggtccgctg ctgtgtccgg caggtcatgc agttggtatt      600

tttcgtgcag cagttagcac ccgtggcgtt gcaaaagcag ttgattttat cccggttgaa      660

agcctggaaa ccaccatgcg tagcccg                                          687


<210>  72
<211>  687
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HCV NS3/4A PR (S139A) with N-terminal 6His and AviTag

<400>  72
atgggtagca gccatcacca tcatcatcat ggtagcggtc tgaacgatat ttttgaagcc       60

cagaaaatcg aatggcatga aggtggtggt ggtagcatga aaaaaaaggg tagcgttgtt      120

attgtgggtc gcattaatct gagcggtgat accgcatatg cacagcagac ccgtggtgaa      180

gaaggttgtc aagaaaccag ccagaccggt cgtgataaaa atcaggttga aggtgaagtt      240

cagattgtta gcaccgcaac acagaccttt ctggcaacca gcattaatgg tgttctgtgg      300

accgtttatc atggtgcagg cacccgtacc attgcaagcc cgaaaggtcc ggttacacag      360

atgtatacca atgtggataa agatctggtt ggttggcagg caccgcaggg tagccgtagt      420

ctgaccccgt gtacctgtgg tagcagcgat ctgtatctgg ttacccgtca tgcagatgtt      480

attccggttc gtcgtcgtgg tgatagccgt ggtagcctgc tgagtccgcg tccgattagc      540

tatctgaaag gtagtgccgg tggtccgctg ctgtgtccgg caggtcatgc agttggtatt      600

tttcgtgcag cagttagcac ccgtggcgtt gcaaaagcag ttgattttat cccggttgaa      660

agcctggaaa ccaccatgcg tagcccg                                          687


<210>  73
<211>  291
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_23

<400>  73
cgtctggatg caccgagcca gattgaagtt aaagatgtta ccgataccac cgcactgatt       60

acctgggttg acccgcgtta cgacgacatt tggtggtttg aactgaccta tggcatcaaa      120

gatgttccgg gtgatcgtac caccattaaa ctgtacctga acgacccgta ctatagcatt      180

ggtaatctga aaccggatac cgaatatgaa gttagcctga ttagctacac tggtgactct      240

tactctcgtt ctggtagcaa tccggcaaaa attaccttta aaaccggtct g               291


<210>  74
<211>  297
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_32

<400>  74
cgtctggatg caccgagcca gattgaagtt aaagatgtta ccgataccac cgcactgatt       60

acctggtggt ctccgcgtta ctactacgct tctatttctg gttttgaact gacctatggc      120

atcaaagatg ttccgggtga tcgtaccacc attaaactgg actacgcttc taacgactat      180

agcattggta atctgaaacc ggataccgaa tatgaagtta gcctgattag ctggaactac      240

ggtgactggc gttactcttc tagcaatccg gcaaaaatta cctttaaaac cggtctg         297


<210>  75
<211>  297
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_33

<400>  75
cgtctggatg caccgagcca gattgaagtt aaagatgtta ccgataccac cgcactgatt       60

acctggtacc cgccgggtcg ttggtacgac gacatttggt actttgaact gacctatggc      120

atcaaagatg ttccgggtga tcgtaccacc attaaactgg ctcgtggtga cgacgtttat      180

agcattggta atctgaaacc ggataccgaa tatgaagtta gcctgattag ctggggtccg      240

gaccgtggtg accgtgctgg tagcaatccg gcaaaaatta cctttaaaac cggtctg         297


<210>  76
<211>  297
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_36

<400>  76
cgtctggatg caccgagcca gattgaagtt aaagatgtta ccgataccac cgcactgatt       60

acctggtctt ggccgcgtga cgacgactac gacatttggt actttgaact gacctatggc      120

atcaaagatg ttccgggtga tcgtaccacc attaaactgc tgaactacgc ttctccgtat      180

agcattggta atctgaaacc ggataccgaa tatgaagtta gcctgattag cgttgttccg      240

gacacttacg gtcgtggtac tagcaatccg gcaaaaatta cctttaaaac cggtctg         297


<210>  77
<211>  288
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_47

<400>  77
cgtctggatg caccgagcca gattgaagtt aaagatgtta ccgataccac cgcactgatt       60

acctggtctc gtccgggtgt ttctatttgg tactttgaac tgacctatgg catcaaagat      120

gttccgggtg atcgtaccac cattaaactg gactaccgtt cttactacta tagcattggt      180

aatctgaaac cggataccga atatgaagtt agcctgatta gcggttctta cggtctggtt      240

ggtgttcgtg ctagcaatcc ggcaaaaatt acctttaaaa ccggtctg                   288


<210>  78
<211>  735
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_01

<400>  78
caggttcagc tggttcagtc tggcgccgaa gtgaagaaac ctggcagcag cgtgaaggtg       60

tcctgcaaag cttctggcgg caccttcagc agctacgcca tctcttgggt tcgacaggcc      120

cctggacaag gcctggaatg gatgggaggc atcatcccca tcttcggcac cgccaattac      180

gcccagaaat tccagggcag agtgaccatc accgccgacg agtctacaag caccgcctac      240

atggaactga gcagcctgag aagcgaggac accgccgtgt actattgtgc cagaggccag      300

ggctactacg gctacttcga ttattggggc cagggcaccc tggtcacagt ttctagcgga      360

ggcggaggat ctggtggcgg aggaagtggc ggaggcggtt ctgctcaatc tgtgctgaca      420

cagcctccta gcgcctctgg aacacctggc cagagagtga caatcagctg tagcggcagc      480

agcagcaaca tcggcagcaa caccgtgaac tggtatcagc agctgcctgg cacagcccct      540

aaactgctga tctacagcaa caaccagcgg cctagcggcg tgcccgatag attttccgtg      600

tctaagagcg gcaccagcgc cagcctggct atttctggac tgcagagcga ggacgaggcc      660

gactattatt gtgccgcctg ggatcacgga cacgagcacg ttgtgtttgg aggcggcacc      720

aagctgacag tgctt                                                       735


<210>  79
<211>  735
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_04

<400>  79
caggtgcagc tggtgcagtc tggcgctgaa gtgaagaagc cgggctcttc tgtgaaggtg       60

tcttgcaagg cttctggcgg caccttctct tcttacgcta tctcttgggt gcgtcaggct      120

ccgggccagg ggctggagtg gatgggcggc atcatcccga tcttcggcac cgctaactac      180

gctcagaaat ttcagggccg tgtgaccatc accgctgatg aatctacctc taccgcttac      240

atggaactgt catctctgcg ttctgaagat accgctgtat actactgcgc tcgtggcatg      300

gctcacttct accagttcga tctgtggggc cagggcaccc tggtaaccgt ctcgagtggt      360

ggtggcggct ctggtggcgg tggctctggc ggtggtggca gtgcacagtc tgtgctgacc      420

cagccgccgt ctgcttctgg caccccgggc cagcgtgtga ccatctcttg ctctggctct      480

tcttctaaca tcggctctaa caccgtgaac tggtaccagc agctgccggg caccgctccg      540

aagctgctga tatactctaa caaccagcgt ccgtctggcg tgccggatcg tttctctggc      600

tctaagtctg gcacctctgc ttctctggct atctctggcc tgcagtctga agacgaagct      660

gattactact gcgctgctgg ggatcacgat cacgaacacg tggtgttcgg cggcggcacc      720

aagctgaccg tgctg                                                       735


<210>  80
<211>  735
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_57

<400>  80
caggtgcagc tggtgcagtc tggcgctgaa gtgaagaagc cgggctcttc tgtgaaggtg       60

tcttgcaagg cttctggcgg caccttctct tcttacgcta tctcttgggt gcgtcaggct      120

ccgggccagg ggctggagtg gatgggcggc atcatcccga tcttcggcac cgctaactac      180

gctcagaaat ttcagggccg tgtgaccatc accgctgatg aatctacctc taccgcttac      240

atggaactgt catctctgcg ttctgaagat accgctgtat actactgcgc tcgtcacacg      300

aactacatca cggttttcga ttactggggc cagggcaccc tggtaaccgt ctcgagtggt      360

ggtggcggct ctggtggcgg tggctctggc ggtggtggca gtgcacagtc tgtgctgacc      420

cagccgccgt ctgcttctgg caccccgggc cagcgtgtga ccatctcttg ctctggctct      480

tcttctaaca tcggctctaa caccgtgaac tggtaccagc agctgccggg caccgctccg      540

aagctgctga tctactctaa caaccagcgt ccgtctggcg tgccggatcg tttctctggc      600

tctaagtctg gcacctctgc ttctctggct atctctggcc tgcagtctga agacgaagct      660

gattactact gcgctgcttg ggatcaccac tgggaacagg tggtgttcgg cggcggcacc      720

aagctgaccg tgctg                                                       735


<210>  81
<211>  735
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_67

<400>  81
gaagtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggccgc agtgaggatt       60

tcctgcaaga catctggata cgtcttcacc agctactatg tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggagtt atcaacccta gtggtggtaa tacgaactac      180

gcacagaagt tccaggacag agtcaccatg accagggaca cgtccacgac cacagtctat      240

atggagttga gcagcctgat gtttgatgac acggccgtgt attactgtgc gaagcgagac      300

tacgggggac ccttggcaaa ctggggccgg ggaaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cactttccta tgagctgact      420

cagccaccct cggtgtctga agccccgagg cagagggtca ccatctcctg ttctggaagc      480

agctccaaca tcggaaataa tgctgtaaac tggtaccagc agctcccagg aaaggctccc      540

aaactcctca ttttttatga tgatctgctg ccctcagggg tctctgaccg attctctggc      600

tccaagtctg gcacctcagc ctccctggcc atcagtgggc tccagtccga ggatgaggct      660

gattattact gtgcagcatg ggatgacagc ctgaatggtc tagtcttcgg aactgggacc      720

aagctgaccg tccta                                                       735


<210>  82
<211>  762
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_72

<400>  82
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc cggggtcctc ggtgaaggtc       60

tcctgcaagg tttctggagg cagcttcaat aattatggtg tcagttgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaagg atcatcccta tccgtgatac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggaca catccacgaa cattgcctac      240

atggaactga gcggcctgag atctgacgac acggccgtgt attactgtgc gagagtactt      300

gaggacgatt tctggggtgg ttattatgac ttctatttct acgttatgga cgtctggggc      360

cagggcaccc tggtcaccgt ctcgagtgga ggcggcggtt caggcggagg tggctctggc      420

ggtggcggaa gtgcactttc ttctgagctg actcaggacc ctgttgtgtc tgtgcccttg      480

ggacagacag ccaggatcac atgccaagga gacagcctca ccacttatta tgcaacctgg      540

taccagcaga agccaggaca ggcccctgtt cttgtcctct ataatgaaca caaaaggccc      600

tcagggatct cagaccgatt ctctggctcc agcgcaggag acgcagcttc cttgaccatc      660

actgacaccc aggcggaaga tgaggccgac tattattgta gctcccggga caccggtggg      720

aagcatgtgc ttttcggcgg agggaccaag ctgaccgtcc ta                         762


<210>  83
<211>  732
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_75

<400>  83
gaggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg ctccttcaac agttatactc tcgactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatccctg tctttggttc cccgaactac      180

ggacagaaat tccagggcag agtcaccatt accgcggacg aatcaacgag cacagcctac      240

atggagctga gcagtctcaa atctgacgac acggccgtgt attactgtgc gcgagggttg      300

gtataccagc cccttgactc ctggggccga ggcaccctgg tcaccgtctc gagtggaggc      360

ggcggttcag gcggaggtgg ctctggcggt ggcggaagtg cacaggctgt gctgactcag      420

ccgtcctcag cgtctgggac ccccgggcag agggtcacca tctcttgttc tggaagcagc      480

tccaacatcg gaagttatac tgtaaactgg taccagcaat tcccaggaac ggcccccaaa      540

ctcctcatct atagtaatac tcagcggccc tcaggggtcc ctgaccgatt ctctggctcc      600

aagtctggca cctcagcctc cctggccatc agtgggctcc agtctgagga tgaggctgat      660

tattactgtg cagcatggga tgacagcctg aatggttggg tgttcggcgg agggaccaag      720

gtcaccgtcc ta                                                          732


<210>  84
<211>  675
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HCV_NS4A_NS3_S139A_SmBiT

<400>  84
atgggcaaga aaaagggctc tgtggtcatc gtgggcagaa tcaacctgag cggcgatacc       60

gcctacgctc agcagacaag aggcgaggaa ggctgccaag agacaagcca gaccggcaga      120

gacaagaacc aggtggaagg cgaggtgcag atcgtgtcta cagctaccca gaccttcctg      180

gccaccagca tcaatggcgt gctgtggaca gtgtatcacg gcgctggcac cagaacaatc      240

gcctctccaa agggccccgt gacacagatg tacaccaacg tggacaagga cctcgtcgga      300

tggcaagccc ctcagggctc tagaagcctg acaccttgta cctgcggcag cagcgatctg      360

tacctggtca caagacacgc cgacgtgatc cccgtcagaa gaagaggcga tagcagaggc      420

agcctgctga gccctagacc tatcagctac ctgaagggat ctgccggcgg acctctgctt      480

tgtcctgctg gacatgccgt gggcatcttt agagccgccg tgtctactag aggcgtggcc      540

aaggccgtgg acttcatccc tgtggaaagc ctggaaacca ccatgcggag cccctctggc      600

tcgagcggtg gtggcgggag cggaggtgga gggtcgtcag gtgtgaccgg ctaccggctg      660

ttcgaggaga ttctg                                                       675


<210>  85
<211>  669
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SmBiT_HCV_NS4A_NS3_S139A

<400>  85
atggtgaccg gctaccggct gttcgaggag attctcggga gttccggtgg tggcgggagc       60

ggaggtggag gctcgagcgg taagaaaaag ggctctgtgg tcatcgtggg cagaatcaac      120

ctgagcggcg ataccgccta cgctcagcag acaagaggcg aggaaggctg ccaagagaca      180

agccagaccg gcagagacaa gaaccaggtg gaaggcgagg tgcagatcgt gtctacagct      240

acccagacct tcctggccac cagcatcaat ggcgtgctgt ggacagtgta tcacggcgct      300

ggcaccagaa caatcgcctc tccaaagggc cccgtgacac agatgtacac caacgtggac      360

aaggacctcg tcggatggca agcccctcag ggctctagaa gcctgacacc ttgtacctgc      420

ggcagcagcg atctgtacct ggtcacaaga cacgccgacg tgatccccgt cagaagaaga      480

ggcgatagca gaggcagcct gctgagccct agacctatca gctacctgaa gggatctgcc      540

ggcggacctc tgctttgtcc tgctggacat gccgtgggca tctttagagc cgccgtgtct      600

actagaggcg tggccaaggc cgtggacttc atccctgtgg aaagcctgga aaccaccatg      660

cggagcccc                                                              669


<210>  86
<211>  822
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_23_LgBiT

<400>  86
atgggctcta gactggatgc ccctagccag atcgaagtga aggacgtgac cgacaccacc       60

gctctgatca cctgggttga ccccagatac gacgacatct ggtggttcga gctgacctac      120

ggcatcaagg atgtgcccgg cgacagaacc accatcaagc tgtacctgaa cgacccctac      180

tacagcatcg gcaacctgaa gcctgacacc gagtacgagg tgtccctgat cagctacacc      240

ggcgactcct acagcagaag cggcagcaat cctgccaaga tcaccttcaa gaccggcctt      300

tctggctcga gcggtggtgg cgggagcgga ggtggagggt cgtcaggtgt cttcacactc      360

gaagatttcg ttggggactg ggaacagaca gccgcctaca acctggacca agtccttgaa      420

cagggaggtg tgtccagttt gctgcagaat ctcgccgtgt ccgtaactcc gatccaaagg      480

attgtccgga gcggtgaaaa tgccctgaag atcgacatcc atgtcatcat cccgtatgaa      540

ggtctgagcg ccgaccaaat ggcccagatc gaagaggtgt ttaaggtggt gtaccctgtg      600

gatgatcatc actttaaggt gatcctgccc tatggcacac tggtaatcga cggggttacg      660

ccgaacatgc tgaactattt cggacggccg tatgaaggca tcgccgtgtt cgacggcaaa      720

aagatcactg taacagggac cctgtggaac ggcaacaaaa ttatcgacga gcgcctgatc      780

acccccgacg gctccatgct gttccgagta accatcaaca gc                         822


<210>  87
<211>  828
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_32_LgBiT

<400>  87
atgggctcta gactggatgc ccctagccag atcgaagtga aggacgtgac cgacaccacc       60

gctctgatca catggtggtc cccacggtac tactacgcca gcatcagcgg cttcgagctg      120

acctacggca tcaaggatgt gcccggcgac agaaccacca tcaagctgga ctacgcctcc      180

aacgactaca gcatcggcaa cctgaagcct gacaccgagt acgaggtgtc cctgatcagc      240

tggaactacg gcgattggcg gtacagcagc agcaaccctg ccaagatcac cttcaagacc      300

ggcctttctg gctcgagcgg tggtggcggg agcggaggtg gagggtcgtc aggtgtcttc      360

acactcgaag atttcgttgg ggactgggaa cagacagccg cctacaacct ggaccaagtc      420

cttgaacagg gaggtgtgtc cagtttgctg cagaatctcg ccgtgtccgt aactccgatc      480

caaaggattg tccggagcgg tgaaaatgcc ctgaagatcg acatccatgt catcatcccg      540

tatgaaggtc tgagcgccga ccaaatggcc cagatcgaag aggtgtttaa ggtggtgtac      600

cctgtggatg atcatcactt taaggtgatc ctgccctatg gcacactggt aatcgacggg      660

gttacgccga acatgctgaa ctatttcgga cggccgtatg aaggcatcgc cgtgttcgac      720

ggcaaaaaga tcactgtaac agggaccctg tggaacggca acaaaattat cgacgagcgc      780

ctgatcaccc ccgacggctc catgctgttc cgagtaacca tcaacagc                   828


<210>  88
<211>  828
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_33_LgBiT

<400>  88
atgggctcta gactggatgc ccctagccag atcgaagtga aggacgtgac cgacaccacc       60

gctctgatca cctggtatcc acctggccgt tggtacgacg acatctggta cttcgagctg      120

acctacggca tcaaggacgt gcccggcgat agaaccacca tcaaactggc cagaggcgac      180

gacgtgtaca gcatcggcaa cctgaagcct gacaccgagt acgaggtgtc cctgatctct      240

tggggccctg acagaggcga tagagccgga tctaaccccg ccaagatcac cttcaagacc      300

ggcctttctg gctcgagcgg tggtggcggg agcggaggtg gagggtcgtc aggtgtcttc      360

acactcgaag atttcgttgg ggactgggaa cagacagccg cctacaacct ggaccaagtc      420

cttgaacagg gaggtgtgtc cagtttgctg cagaatctcg ccgtgtccgt aactccgatc      480

caaaggattg tccggagcgg tgaaaatgcc ctgaagatcg acatccatgt catcatcccg      540

tatgaaggtc tgagcgccga ccaaatggcc cagatcgaag aggtgtttaa ggtggtgtac      600

cctgtggatg atcatcactt taaggtgatc ctgccctatg gcacactggt aatcgacggg      660

gttacgccga acatgctgaa ctatttcgga cggccgtatg aaggcatcgc cgtgttcgac      720

ggcaaaaaga tcactgtaac agggaccctg tggaacggca acaaaattat cgacgagcgc      780

ctgatcaccc ccgacggctc catgctgttc cgagtaacca tcaacagc                   828


<210>  89
<211>  828
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_36_LgBiT

<400>  89
atgggctcta gactggatgc ccctagccag atcgaagtga aggacgtgac cgacaccacc       60

gctctgatca cctggtcctg gcctagagat gacgactacg acatctggta cttcgagctg      120

acctacggca tcaaggacgt gcccggcgat agaaccacca tcaagctgct gaactacgcc      180

tctccataca gcatcggcaa cctgaagcct gacaccgagt acgaggtgtc cctgatcagc      240

gtggtgcccg acacatatgg cagaggcaca agcaaccccg ccaagatcac cttcaagacc      300

ggactttctg gctcgagcgg tggtggcggg agcggaggtg gagggtcgtc aggtgtcttc      360

acactcgaag atttcgttgg ggactgggaa cagacagccg cctacaacct ggaccaagtc      420

cttgaacagg gaggtgtgtc cagtttgctg cagaatctcg ccgtgtccgt aactccgatc      480

caaaggattg tccggagcgg tgaaaatgcc ctgaagatcg acatccatgt catcatcccg      540

tatgaaggtc tgagcgccga ccaaatggcc cagatcgaag aggtgtttaa ggtggtgtac      600

cctgtggatg atcatcactt taaggtgatc ctgccctatg gcacactggt aatcgacggg      660

gttacgccga acatgctgaa ctatttcgga cggccgtatg aaggcatcgc cgtgttcgac      720

ggcaaaaaga tcactgtaac agggaccctg tggaacggca acaaaattat cgacgagcgc      780

ctgatcaccc ccgacggctc catgctgttc cgagtaacca tcaacagc                   828


<210>  90
<211>  819
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_47_LgBiT

<400>  90
atgggctcta gactggatgc ccctagccag atcgaagtga aggacgtgac cgacaccacc       60

gctctgatca cctggtcaag acctggcgtg tccatctggt acttcgagct gacctacggc      120

atcaaggacg tgcccggcga tagaaccacc atcaagctgg actaccgcag ctactactac      180

agcatcggca acctgaagcc tgacaccgag tacgaggtgt ccctgatcag cggctcttat      240

ggcctcgtgg gcgtcagagc ctctaatccc gccaagatca cctttaagac cggcctttct      300

ggctcgagcg gtggtggcgg gagcggaggt ggagggtcgt caggtgtctt cacactcgaa      360

gatttcgttg gggactggga acagacagcc gcctacaacc tggaccaagt ccttgaacag      420

ggaggtgtgt ccagtttgct gcagaatctc gccgtgtccg taactccgat ccaaaggatt      480

gtccggagcg gtgaaaatgc cctgaagatc gacatccatg tcatcatccc gtatgaaggt      540

ctgagcgccg accaaatggc ccagatcgaa gaggtgttta aggtggtgta ccctgtggat      600

gatcatcact ttaaggtgat cctgccctat ggcacactgg taatcgacgg ggttacgccg      660

aacatgctga actatttcgg acggccgtat gaaggcatcg ccgtgttcga cggcaaaaag      720

atcactgtaa cagggaccct gtggaacggc aacaaaatta tcgacgagcg cctgatcacc      780

cccgacggct ccatgctgtt ccgagtaacc atcaacagc                             819


<210>  91
<211>  1266
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_01_LgBiT

<400>  91
atgggatctc aggttcagct ggttcagtct ggcgccgaag tgaagaaacc tggcagcagc       60

gtgaaggtgt cctgcaaagc ttctggcggc accttcagca gctacgccat ctcttgggtt      120

cgacaggccc ctggacaagg cctggaatgg atgggaggca tcatccccat cttcggcacc      180

gccaattacg cccagaaatt ccagggcaga gtgaccatca ccgccgacga gtctacaagc      240

accgcctaca tggaactgag cagcctgaga agcgaggaca ccgccgtgta ctattgtgcc      300

agaggccagg gctactacgg ctacttcgat tattggggcc agggcaccct ggtcacagtt      360

tctagcggag gcggaggatc tggtggcgga ggaagtggcg gaggcggttc tgctcaatct      420

gtgctgacac agcctcctag cgcctctgga acacctggcc agagagtgac aatcagctgt      480

agcggcagca gcagcaacat cggcagcaac accgtgaact ggtatcagca gctgcctggc      540

acagccccta aactgctgat ctacagcaac aaccagcggc ctagcggcgt gcccgataga      600

ttttccgtgt ctaagagcgg caccagcgcc agcctggcta tttctggact gcagagcgag      660

gacgaggccg actattattg tgccgcctgg gatcacggac acgagcacgt tgtgtttgga      720

ggcggcacca agctgacagt gctttctggc tcgagcggtg gtggcgggag cggaggtgga      780

gggtcgtcag gtgtcttcac actcgaagat ttcgttgggg actgggaaca gacagccgcc      840

tacaacctgg accaagtcct tgaacaggga ggtgtgtcca gtttgctgca gaatctcgcc      900

gtgtccgtaa ctccgatcca aaggattgtc cggagcggtg aaaatgccct gaagatcgac      960

atccatgtca tcatcccgta tgaaggtctg agcgccgacc aaatggccca gatcgaagag     1020

gtgtttaagg tggtgtaccc tgtggatgat catcacttta aggtgatcct gccctatggc     1080

acactggtaa tcgacggggt tacgccgaac atgctgaact atttcggacg gccgtatgaa     1140

ggcatcgccg tgttcgacgg caaaaagatc actgtaacag ggaccctgtg gaacggcaac     1200

aaaattatcg acgagcgcct gatcaccccc gacggctcca tgctgttccg agtaaccatc     1260

aacagc                                                                1266


<210>  92
<211>  1266
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_06_LgBiT

<400>  92
atgggctctc aggtgcagct tgttcagtct ggcgccgaag tgaagaaacc cggcagctct       60

gtgaaggtgt cctgcaaagc ttccggcggc acctttagca gctacgccat ctcttgggtc      120

cgacaggctc ctggacaagg cctggaatgg atgggcggca tcatccctat cttcggcacc      180

gccaattacg cccagaaatt ccagggcaga gtgaccatca ccgccgacga gtctacaagc      240

accgcctaca tggaactgag cagcctgaga agcgaggaca ccgccgtgta ctactgtgct      300

agaggcgctg gctactacat gagagtggac tattggggcc agggcaccct ggtcacagtt      360

tctagcggag gcggaggatc tggcggcgga ggtagtggtg gtggcggatc tgctcagtct      420

gtgctgacac agcctcctag cgcctctgga acacctggcc agagagtgac aatcagctgt      480

agcggcagca gcagcaacat cggcagcaac accgtgaact ggtatcagca gctgcctggc      540

acagccccta aactgctgat ctacagcaac aaccagcggc ctagcggcgt gcccgataga      600

ttttctggca gcaagagcgg cacaagcgcc agcctggcta tttctggact gcagagcgag      660

gacgaggccg actattattg tgccgcctgg gaccacgacg tggaacacgt tgtgtttggc      720

ggaggcacca agctgacagt gctttctggc tcgagcggtg gtggcgggag cggaggtgga      780

gggtcgtcag gtgtcttcac actcgaagat ttcgttgggg actgggaaca gacagccgcc      840

tacaacctgg accaagtcct tgaacaggga ggtgtgtcca gtttgctgca gaatctcgcc      900

gtgtccgtaa ctccgatcca aaggattgtc cggagcggtg aaaatgccct gaagatcgac      960

atccatgtca tcatcccgta tgaaggtctg agcgccgacc aaatggccca gatcgaagag     1020

gtgtttaagg tggtgtaccc tgtggatgat catcacttta aggtgatcct gccctatggc     1080

acactggtaa tcgacggggt tacgccgaac atgctgaact atttcggacg gccgtatgaa     1140

ggcatcgccg tgttcgacgg caaaaagatc actgtaacag ggaccctgtg gaacggcaac     1200

aaaattatcg acgagcgcct gatcaccccc gacggctcca tgctgttccg agtaaccatc     1260

aacagc                                                                1266


<210>  93
<211>  1266
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_57_LgBiT

<400>  93
atgggctctc aggttcagct ggttcagtct ggcgccgaag tgaagaaacc tggcagcagc       60

gtgaaggtgt cctgcaaagc ttctggcggc accttcagca gctacgccat ctcttgggtt      120

cgacaggccc ctggacaagg cctggaatgg atgggaggca tcatccccat cttcggcacc      180

gccaattacg cccagaaatt ccagggcaga gtgaccatca ccgccgacga gtctacaagc      240

accgcctaca tggaactgag cagcctgaga agcgaggaca ccgccgtgta ctactgtgcc      300

agacacacca actacatcac cgtgttcgac tactggggcc agggcacact ggtcacagtt      360

tctagcggag gcggaggatc tggtggcgga ggaagtggcg gaggcggttc tgctcaatct      420

gtgctgacac agcctcctag cgcctctgga acacctggcc agagagtgac aatcagctgt      480

agcggcagca gcagcaacat cggcagcaac accgtgaact ggtatcagca gctgcctggc      540

acagccccta aactgctgat ctacagcaac aaccagcggc ctagcggcgt gcccgataga      600

ttttctggca gcaagagcgg cacaagcgcc agcctggcta tttctggact gcagagcgag      660

gacgaggccg actattattg tgccgcctgg gaccaccact gggagcaagt tgtttttgga      720

ggcggcacca agctgaccgt gctttctggc tcgagcggtg gtggcgggag cggaggtgga      780

gggtcgtcag gtgtcttcac actcgaagat ttcgttgggg actgggaaca gacagccgcc      840

tacaacctgg accaagtcct tgaacaggga ggtgtgtcca gtttgctgca gaatctcgcc      900

gtgtccgtaa ctccgatcca aaggattgtc cggagcggtg aaaatgccct gaagatcgac      960

atccatgtca tcatcccgta tgaaggtctg agcgccgacc aaatggccca gatcgaagag     1020

gtgtttaagg tggtgtaccc tgtggatgat catcacttta aggtgatcct gccctatggc     1080

acactggtaa tcgacggggt tacgccgaac atgctgaact atttcggacg gccgtatgaa     1140

ggcatcgccg tgttcgacgg caaaaagatc actgtaacag ggaccctgtg gaacggcaac     1200

aaaattatcg acgagcgcct gatcaccccc gacggctcca tgctgttccg agtaaccatc     1260

aacagc                                                                1266


<210>  94
<211>  1266
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_67_LgBiT

<400>  94
atgggctctg aagtgcagct ggttcagtct ggcgccgaag tgaagaaacc tggcgccgct       60

gtcagaatca gctgcaagac aagcggctac gtgttcacca gctactacgt gcactgggtc      120

cgacaggctc caggacaagg actggaatgg atgggcgtga tcaatcccag cggcggcaac      180

accaattacg cccagaaatt ccaggaccgc gtgaccatga ccagagacac cagcaccacc      240

accgtgtaca tggaactgag cagcctgatg ttcgacgaca ccgccgtgta ctactgcgcc      300

aagagagatt acggcggacc cctggccaat tggggcagag gaacactggt cacagtgtct      360

agcggaggcg gaggatctgg tggcggagga agtggcggag gcggttctgc tctgagctat      420

gagctgacac agcctccaag cgtgtccgag gctcctagac agagagtgac catcagctgt      480

agcggcagca gcagcaacat cggcaacaac gccgtgaact ggtatcagca gctgcctggc      540

aaggccccta aactgctgat cttctacgac gacctgctgc ctagcggagt gtccgataga      600

ttcagcggct ctaagagcgg cacatctgcc agcctggcca tctctggact gcagagcgaa      660

gatgaggccg actactattg cgccgcctgg gacgattctc tgaacggcct ggtttttggc      720

accggcacca agctgacagt gctgtctggc tcgagcggtg gtggcgggag cggaggtgga      780

gggtcgtcag gtgtcttcac actcgaagat ttcgttgggg actgggaaca gacagccgcc      840

tacaacctgg accaagtcct tgaacaggga ggtgtgtcca gtttgctgca gaatctcgcc      900

gtgtccgtaa ctccgatcca aaggattgtc cggagcggtg aaaatgccct gaagatcgac      960

atccatgtca tcatcccgta tgaaggtctg agcgccgacc aaatggccca gatcgaagag     1020

gtgtttaagg tggtgtaccc tgtggatgat catcacttta aggtgatcct gccctatggc     1080

acactggtaa tcgacggggt tacgccgaac atgctgaact atttcggacg gccgtatgaa     1140

ggcatcgccg tgttcgacgg caaaaagatc actgtaacag ggaccctgtg gaacggcaac     1200

aaaattatcg acgagcgcct gatcaccccc gacggctcca tgctgttccg agtaaccatc     1260

aacagc                                                                1266


<210>  95
<211>  1293
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_72_LgBiT

<400>  95
atgggatctc aggttcagct ggttcagtct ggcgccgaag tgaagaaacc tggcagcagc       60

gtgaaggtgt cctgcaaagt gtctggcggc agcttcaaca actacggcgt gtcctgggtt      120

cgacaggccc ctggacaagg actggaatgg atgggcagaa tcatccccat ccgggacacc      180

gccaattacg cccagaaatt ccagggcaga gtgaccatca ccgccgacac cagcaccaat      240

atcgcctaca tggaactgag cggcctgcgg agtgatgaca ccgccgtgta ctattgcgcc      300

agagtgctgg aagatgactt ctggggcggc tactacgact tctacttcta cgtgatggac      360

gtgtggggcc agggcacact ggttacagtt tctagcggag gcggaggatc tggtggcgga      420

ggaagtggcg gaggcggttc tgctctttct agcgagctga cccaggatcc agtggtgtct      480

gttcctctgg gccagaccgc cagaattacc tgtcagggcg atagcctgac cacctactac      540

gccacctggt atcagcagaa gccaggccag gctcctgtgc tggtgctgta caatgagcac      600

aagaggccca gcggcatcag cgacagattt tctggatctt ctgccggcga cgccgccagc      660

ctgacaatca cagatacaca ggccgaggac gaggccgact actactgcag ctctagagat      720

accggcggca aacacgtgct gtttggaggc ggcacaaagc tgacagtgct ttctggctcg      780

agcggtggtg gcgggagcgg aggtggaggg tcgtcaggtg tcttcacact cgaagatttc      840

gttggggact gggaacagac agccgcctac aacctggacc aagtccttga acagggaggt      900

gtgtccagtt tgctgcagaa tctcgccgtg tccgtaactc cgatccaaag gattgtccgg      960

agcggtgaaa atgccctgaa gatcgacatc catgtcatca tcccgtatga aggtctgagc     1020

gccgaccaaa tggcccagat cgaagaggtg tttaaggtgg tgtaccctgt ggatgatcat     1080

cactttaagg tgatcctgcc ctatggcaca ctggtaatcg acggggttac gccgaacatg     1140

ctgaactatt tcggacggcc gtatgaaggc atcgccgtgt tcgacggcaa aaagatcact     1200

gtaacaggga ccctgtggaa cggcaacaaa attatcgacg agcgcctgat cacccccgac     1260

ggctccatgc tgttccgagt aaccatcaac agc                                  1293


<210>  96
<211>  1263
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_75_LgBiT

<400>  96
atgggatctg aagtgcagct ggttcagtct ggcgccgaag tgaagaaacc tggcagcagc       60

gtgaaggtgt cctgcaaagc ttctggcggc agcttcaaca gctacaccct ggactgggtt      120

cgacaggccc ctggacaagg actggaatgg atgggcggaa tcatccccgt gttcggcagc      180

cctaattacg gccagaaatt ccagggcaga gtgaccatca ccgccgacga gtctacaagc      240

accgcctaca tggaactgag cagcctgaag tccgacgaca ccgccgtgta ctattgtgcc      300

agaggcctgg tgtaccagcc actggattct tggggcagag gcaccctggt cacagtttct      360

agcggaggcg gaggatctgg tggcggagga agtggcggag gcggttctgc tcaagctgtt      420

ctgacacagc ctagcagcgc ctctggaaca cctggccaga gagtgacaat cagctgtagc      480

ggcagcagca gcaacatcgg ctcctacacc gtgaactggt atcagcagtt ccccggcaca      540

gcccctaagc tgctgatcta cagcaacacc cagaggccaa gcggcgtgcc cgatagattt      600

tctggcagca agagcggcac aagcgccagc ctggctattt ctggactgca gagcgaggac      660

gaggccgact attattgtgc cgcctgggac gacagcctga acggatgggt tttcggcgga      720

ggcaccaaag tgacagtgct ttctggctcg agcggtggtg gcgggagcgg aggtggaggg      780

tcgtcaggtg tcttcacact cgaagatttc gttggggact gggaacagac agccgcctac      840

aacctggacc aagtccttga acagggaggt gtgtccagtt tgctgcagaa tctcgccgtg      900

tccgtaactc cgatccaaag gattgtccgg agcggtgaaa atgccctgaa gatcgacatc      960

catgtcatca tcccgtatga aggtctgagc gccgaccaaa tggcccagat cgaagaggtg     1020

tttaaggtgg tgtaccctgt ggatgatcat cactttaagg tgatcctgcc ctatggcaca     1080

ctggtaatcg acggggttac gccgaacatg ctgaactatt tcggacggcc gtatgaaggc     1140

atcgccgtgt tcgacggcaa aaagatcact gtaacaggga ccctgtggaa cggcaacaaa     1200

attatcgacg agcgcctgat cacccccgac ggctccatgc tgttccgagt aaccatcaac     1260

agc                                                                   1263


<210>  97
<211>  813
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LgBiT_PRSIM_23

<400>  97
atggtcttca cactcgaaga tttcgttggg gactgggaac agacagccgc ctacaacctg       60

gaccaagtcc ttgaacaggg aggtgtgtcc agtttgctgc agaatctcgc cgtgtccgta      120

actccgatcc aaaggattgt ccggagcggt gaaaatgccc tgaagatcga catccatgtc      180

atcatcccgt atgaaggtct gagcgccgac caaatggccc agatcgaaga ggtgtttaag      240

gtggtgtacc ctgtggatga tcatcacttt aaggtgatcc tgccctatgg cacactggta      300

atcgacgggg ttacgccgaa catgctgaac tatttcggac ggccgtatga aggcatcgcc      360

gtgttcgacg gcaaaaagat cactgtaaca gggaccctgt ggaacggcaa caaaattatc      420

gacgagcgcc tgatcacccc cgacggctcc atgctgttcc gagtaaccat caacagtggg      480

agttccggtg gtggcgggag cggaggtgga ggctcgagcg gtagactgga tgcccctagc      540

cagatcgaag tgaaggacgt gaccgacacc accgctctga tcacctgggt tgaccccaga      600

tacgacgaca tctggtggtt cgagctgacc tacggcatca aggatgtgcc cggcgacaga      660

accaccatca agctgtacct gaacgacccc tactacagca tcggcaacct gaagcctgac      720

accgagtacg aggtgtccct gatcagctac accggcgact cctacagcag aagcggcagc      780

aatcctgcca agatcacctt caagaccggc ctt                                   813


<210>  98
<211>  819
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LgBiT_PRSIM_32

<400>  98
atggtcttca cactcgaaga tttcgttggg gactgggaac agacagccgc ctacaacctg       60

gaccaagtcc ttgaacaggg aggtgtgtcc agtttgctgc agaatctcgc cgtgtccgta      120

actccgatcc aaaggattgt ccggagcggt gaaaatgccc tgaagatcga catccatgtc      180

atcatcccgt atgaaggtct gagcgccgac caaatggccc agatcgaaga ggtgtttaag      240

gtggtgtacc ctgtggatga tcatcacttt aaggtgatcc tgccctatgg cacactggta      300

atcgacgggg ttacgccgaa catgctgaac tatttcggac ggccgtatga aggcatcgcc      360

gtgttcgacg gcaaaaagat cactgtaaca gggaccctgt ggaacggcaa caaaattatc      420

gacgagcgcc tgatcacccc cgacggctcc atgctgttcc gagtaaccat caacagtggg      480

agttccggtg gtggcgggag cggaggtgga ggctcgagcg gtagactgga tgcccctagc      540

cagatcgaag tgaaggacgt gaccgacacc accgctctga tcacatggtg gtccccacgg      600

tactactacg ccagcatcag cggcttcgag ctgacctacg gcatcaagga tgtgcccggc      660

gacagaacca ccatcaagct ggactacgcc tccaacgact acagcatcgg caacctgaag      720

cctgacaccg agtacgaggt gtccctgatc agctggaact acggcgattg gcggtacagc      780

agcagcaacc ctgccaagat caccttcaag accggcctt                             819


<210>  99
<211>  819
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LgBiT_PRSIM_33

<400>  99
atggtcttca cactcgaaga tttcgttggg gactgggaac agacagccgc ctacaacctg       60

gaccaagtcc ttgaacaggg aggtgtgtcc agtttgctgc agaatctcgc cgtgtccgta      120

actccgatcc aaaggattgt ccggagcggt gaaaatgccc tgaagatcga catccatgtc      180

atcatcccgt atgaaggtct gagcgccgac caaatggccc agatcgaaga ggtgtttaag      240

gtggtgtacc ctgtggatga tcatcacttt aaggtgatcc tgccctatgg cacactggta      300

atcgacgggg ttacgccgaa catgctgaac tatttcggac ggccgtatga aggcatcgcc      360

gtgttcgacg gcaaaaagat cactgtaaca gggaccctgt ggaacggcaa caaaattatc      420

gacgagcgcc tgatcacccc cgacggctcc atgctgttcc gagtaaccat caacagtggg      480

agttccggtg gtggcgggag cggaggtgga ggctcgagcg gtagactgga tgcccctagc      540

cagatcgaag tgaaggacgt gaccgacacc accgctctga tcacctggta tccacctggc      600

cgttggtacg acgacatctg gtacttcgag ctgacctacg gcatcaagga cgtgcccggc      660

gatagaacca ccatcaaact ggccagaggc gacgacgtgt acagcatcgg caacctgaag      720

cctgacaccg agtacgaggt gtccctgatc tcttggggcc ctgacagagg cgatagagcc      780

ggatctaacc ccgccaagat caccttcaag accggcctt                             819


<210>  100
<211>  819
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LgBiT_PRSIM_36

<400>  100
atggtcttca cactcgaaga tttcgttggg gactgggaac agacagccgc ctacaacctg       60

gaccaagtcc ttgaacaggg aggtgtgtcc agtttgctgc agaatctcgc cgtgtccgta      120

actccgatcc aaaggattgt ccggagcggt gaaaatgccc tgaagatcga catccatgtc      180

atcatcccgt atgaaggtct gagcgccgac caaatggccc agatcgaaga ggtgtttaag      240

gtggtgtacc ctgtggatga tcatcacttt aaggtgatcc tgccctatgg cacactggta      300

atcgacgggg ttacgccgaa catgctgaac tatttcggac ggccgtatga aggcatcgcc      360

gtgttcgacg gcaaaaagat cactgtaaca gggaccctgt ggaacggcaa caaaattatc      420

gacgagcgcc tgatcacccc cgacggctcc atgctgttcc gagtaaccat caacagtggg      480

agttccggtg gtggcgggag cggaggtgga ggctcgagcg gtagactgga tgcccctagc      540

cagatcgaag tgaaggacgt gaccgacacc accgctctga tcacctggtc ctggcctaga      600

gatgacgact acgacatctg gtacttcgag ctgacctacg gcatcaagga cgtgcccggc      660

gatagaacca ccatcaagct gctgaactac gcctctccat acagcatcgg caacctgaag      720

cctgacaccg agtacgaggt gtccctgatc agcgtggtgc ccgacacata tggcagaggc      780

acaagcaacc ccgccaagat caccttcaag accggactt                             819


<210>  101
<211>  810
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LgBiT_PRSIM_47

<400>  101
atggtcttca cactcgaaga tttcgttggg gactgggaac agacagccgc ctacaacctg       60

gaccaagtcc ttgaacaggg aggtgtgtcc agtttgctgc agaatctcgc cgtgtccgta      120

actccgatcc aaaggattgt ccggagcggt gaaaatgccc tgaagatcga catccatgtc      180

atcatcccgt atgaaggtct gagcgccgac caaatggccc agatcgaaga ggtgtttaag      240

gtggtgtacc ctgtggatga tcatcacttt aaggtgatcc tgccctatgg cacactggta      300

atcgacgggg ttacgccgaa catgctgaac tatttcggac ggccgtatga aggcatcgcc      360

gtgttcgacg gcaaaaagat cactgtaaca gggaccctgt ggaacggcaa caaaattatc      420

gacgagcgcc tgatcacccc cgacggctcc atgctgttcc gagtaaccat caacagtggg      480

agttccggtg gtggcgggag cggaggtgga ggctcgagcg gtagactgga tgcccctagc      540

cagatcgaag tgaaggacgt gaccgacacc accgctctga tcacctggtc aagacctggc      600

gtgtccatct ggtacttcga gctgacctac ggcatcaagg acgtgcccgg cgatagaacc      660

accatcaagc tggactaccg cagctactac tacagcatcg gcaacctgaa gcctgacacc      720

gagtacgagg tgtccctgat cagcggctct tatggcctcg tgggcgtcag agcctctaat      780

cccgccaaga tcacctttaa gaccggcctt                                       810


<210>  102
<211>  1257
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LgBiT_PRSIM_01

<400>  102
atggtcttca cactcgaaga tttcgttggg gactgggaac agacagccgc ctacaacctg       60

gaccaagtcc ttgaacaggg aggtgtgtcc agtttgctgc agaatctcgc cgtgtccgta      120

actccgatcc aaaggattgt ccggagcggt gaaaatgccc tgaagatcga catccatgtc      180

atcatcccgt atgaaggtct gagcgccgac caaatggccc agatcgaaga ggtgtttaag      240

gtggtgtacc ctgtggatga tcatcacttt aaggtgatcc tgccctatgg cacactggta      300

atcgacgggg ttacgccgaa catgctgaac tatttcggac ggccgtatga aggcatcgcc      360

gtgttcgacg gcaaaaagat cactgtaaca gggaccctgt ggaacggcaa caaaattatc      420

gacgagcgcc tgatcacccc cgacggctcc atgctgttcc gagtaaccat caacagtggg      480

agttccggtg gtggcgggag cggaggtgga ggctcgagcg gtcaggttca gctggttcag      540

tctggcgccg aagtgaagaa acctggcagc agcgtgaagg tgtcctgcaa agcttctggc      600

ggcaccttca gcagctacgc catctcttgg gttcgacagg cccctggaca aggcctggaa      660

tggatgggag gcatcatccc catcttcggc accgccaatt acgcccagaa attccagggc      720

agagtgacca tcaccgccga cgagtctaca agcaccgcct acatggaact gagcagcctg      780

agaagcgagg acaccgccgt gtactattgt gccagaggcc agggctacta cggctacttc      840

gattattggg gccagggcac cctggtcaca gtttctagcg gaggcggagg atctggtggc      900

ggaggaagtg gcggaggcgg ttctgctcaa tctgtgctga cacagcctcc tagcgcctct      960

ggaacacctg gccagagagt gacaatcagc tgtagcggca gcagcagcaa catcggcagc     1020

aacaccgtga actggtatca gcagctgcct ggcacagccc ctaaactgct gatctacagc     1080

aacaaccagc ggcctagcgg cgtgcccgat agattttccg tgtctaagag cggcaccagc     1140

gccagcctgg ctatttctgg actgcagagc gaggacgagg ccgactatta ttgtgccgcc     1200

tgggatcacg gacacgagca cgttgtgttt ggaggcggca ccaagctgac agtgctt        1257


<210>  103
<211>  1257
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LgBiT_PRSIM_06

<400>  103
atggtcttca cactcgaaga tttcgttggg gactgggaac agacagccgc ctacaacctg       60

gaccaagtcc ttgaacaggg aggtgtgtcc agtttgctgc agaatctcgc cgtgtccgta      120

actccgatcc aaaggattgt ccggagcggt gaaaatgccc tgaagatcga catccatgtc      180

atcatcccgt atgaaggtct gagcgccgac caaatggccc agatcgaaga ggtgtttaag      240

gtggtgtacc ctgtggatga tcatcacttt aaggtgatcc tgccctatgg cacactggta      300

atcgacgggg ttacgccgaa catgctgaac tatttcggac ggccgtatga aggcatcgcc      360

gtgttcgacg gcaaaaagat cactgtaaca gggaccctgt ggaacggcaa caaaattatc      420

gacgagcgcc tgatcacccc cgacggctcc atgctgttcc gagtaaccat caacagtggg      480

agttccggtg gtggcgggag cggaggtgga ggctcgagcg gtcaggtgca gcttgttcag      540

tctggcgccg aagtgaagaa acccggcagc tctgtgaagg tgtcctgcaa agcttccggc      600

ggcaccttta gcagctacgc catctcttgg gtccgacagg ctcctggaca aggcctggaa      660

tggatgggcg gcatcatccc tatcttcggc accgccaatt acgcccagaa attccagggc      720

agagtgacca tcaccgccga cgagtctaca agcaccgcct acatggaact gagcagcctg      780

agaagcgagg acaccgccgt gtactactgt gctagaggcg ctggctacta catgagagtg      840

gactattggg gccagggcac cctggtcaca gtttctagcg gaggcggagg atctggcggc      900

ggaggtagtg gtggtggcgg atctgctcag tctgtgctga cacagcctcc tagcgcctct      960

ggaacacctg gccagagagt gacaatcagc tgtagcggca gcagcagcaa catcggcagc     1020

aacaccgtga actggtatca gcagctgcct ggcacagccc ctaaactgct gatctacagc     1080

aacaaccagc ggcctagcgg cgtgcccgat agattttctg gcagcaagag cggcacaagc     1140

gccagcctgg ctatttctgg actgcagagc gaggacgagg ccgactatta ttgtgccgcc     1200

tgggaccacg acgtggaaca cgttgtgttt ggcggaggca ccaagctgac agtgctt        1257


<210>  104
<211>  1257
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LgBiT_PRSIM_57

<400>  104
atggtcttca cactcgaaga tttcgttggg gactgggaac agacagccgc ctacaacctg       60

gaccaagtcc ttgaacaggg aggtgtgtcc agtttgctgc agaatctcgc cgtgtccgta      120

actccgatcc aaaggattgt ccggagcggt gaaaatgccc tgaagatcga catccatgtc      180

atcatcccgt atgaaggtct gagcgccgac caaatggccc agatcgaaga ggtgtttaag      240

gtggtgtacc ctgtggatga tcatcacttt aaggtgatcc tgccctatgg cacactggta      300

atcgacgggg ttacgccgaa catgctgaac tatttcggac ggccgtatga aggcatcgcc      360

gtgttcgacg gcaaaaagat cactgtaaca gggaccctgt ggaacggcaa caaaattatc      420

gacgagcgcc tgatcacccc cgacggctcc atgctgttcc gagtaaccat caacagtggg      480

agttccggtg gtggcgggag cggaggtgga ggctcgagcg gtcaggttca gctggttcag      540

tctggcgccg aagtgaagaa acctggcagc agcgtgaagg tgtcctgcaa agcttctggc      600

ggcaccttca gcagctacgc catctcttgg gttcgacagg cccctggaca aggcctggaa      660

tggatgggag gcatcatccc catcttcggc accgccaatt acgcccagaa attccagggc      720

agagtgacca tcaccgccga cgagtctaca agcaccgcct acatggaact gagcagcctg      780

agaagcgagg acaccgccgt gtactactgt gccagacaca ccaactacat caccgtgttc      840

gactactggg gccagggcac actggtcaca gtttctagcg gaggcggagg atctggtggc      900

ggaggaagtg gcggaggcgg ttctgctcaa tctgtgctga cacagcctcc tagcgcctct      960

ggaacacctg gccagagagt gacaatcagc tgtagcggca gcagcagcaa catcggcagc     1020

aacaccgtga actggtatca gcagctgcct ggcacagccc ctaaactgct gatctacagc     1080

aacaaccagc ggcctagcgg cgtgcccgat agattttctg gcagcaagag cggcacaagc     1140

gccagcctgg ctatttctgg actgcagagc gaggacgagg ccgactatta ttgtgccgcc     1200

tgggaccacc actgggagca agttgttttt ggaggcggca ccaagctgac cgtgctt        1257


<210>  105
<211>  1257
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LgBiT_PRSIM_67

<400>  105
atggtcttca cactcgaaga tttcgttggg gactgggaac agacagccgc ctacaacctg       60

gaccaagtcc ttgaacaggg aggtgtgtcc agtttgctgc agaatctcgc cgtgtccgta      120

actccgatcc aaaggattgt ccggagcggt gaaaatgccc tgaagatcga catccatgtc      180

atcatcccgt atgaaggtct gagcgccgac caaatggccc agatcgaaga ggtgtttaag      240

gtggtgtacc ctgtggatga tcatcacttt aaggtgatcc tgccctatgg cacactggta      300

atcgacgggg ttacgccgaa catgctgaac tatttcggac ggccgtatga aggcatcgcc      360

gtgttcgacg gcaaaaagat cactgtaaca gggaccctgt ggaacggcaa caaaattatc      420

gacgagcgcc tgatcacccc cgacggctcc atgctgttcc gagtaaccat caacagtggg      480

agttccggtg gtggcgggag cggaggtgga ggctcgagcg gtgaagtgca gctggttcag      540

tctggcgccg aagtgaagaa acctggcgcc gctgtcagaa tcagctgcaa gacaagcggc      600

tacgtgttca ccagctacta cgtgcactgg gtccgacagg ctccaggaca aggactggaa      660

tggatgggcg tgatcaatcc cagcggcggc aacaccaatt acgcccagaa attccaggac      720

cgcgtgacca tgaccagaga caccagcacc accaccgtgt acatggaact gagcagcctg      780

atgttcgacg acaccgccgt gtactactgc gccaagagag attacggcgg acccctggcc      840

aattggggca gaggaacact ggtcacagtg tctagcggag gcggaggatc tggtggcgga      900

ggaagtggcg gaggcggttc tgctctgagc tatgagctga cacagcctcc aagcgtgtcc      960

gaggctccta gacagagagt gaccatcagc tgtagcggca gcagcagcaa catcggcaac     1020

aacgccgtga actggtatca gcagctgcct ggcaaggccc ctaaactgct gatcttctac     1080

gacgacctgc tgcctagcgg agtgtccgat agattcagcg gctctaagag cggcacatct     1140

gccagcctgg ccatctctgg actgcagagc gaagatgagg ccgactacta ttgcgccgcc     1200

tgggacgatt ctctgaacgg cctggttttt ggcaccggca ccaagctgac agtgctg        1257


<210>  106
<211>  1283
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LgBiT_PRSIM_72

<400>  106
atggtcttca cactcgaaga tttcgttggg gactgggaac agacagccgc ctacaacctg       60

gaccaagtcc ttgaacaggg aggtgtgtcc agtttgctgc agaatctcgc cgtgtccgta      120

actccgatcc aaaggattgt ccggagcggt gaaaatgccc tgaagatcga catccatgtc      180

atcatcccgt atgaaggtct gagcgccgac caaatggccc agatcgaaga ggtgtttaag      240

gtggtgtacc ctgtggatga tcatcacttt aaggtgatcc tgccctatgg cacactggta      300

atcgacgggg ttacgccgaa catgctgaac tatttcggac ggccgtatga aggcatcgcc      360

gtgttcgacg gcaaaaagat cactgtaaca gggaccctgt ggaacggcaa caaaattatc      420

gacgagcgcc tgatcacccc cgacggctcc atgctgttcc gagtaaccat caacagtggg      480

agttccggtg gtggcgggag cggaggtgga ggctcgagcg gtcaggttca gctggttcag      540

tctggcgccg aagtgaagaa acctggcagc agcgtgaagg tgtcctgcaa agtgtctggc      600

ggcagcttca acaactacgg cgtgtcctgg gttcgacagg cccctggaca aggactggaa      660

tggatgggca gaatcatccc catccgggac accgccaatt acgcccagaa attccagggc      720

agagtgacca tcaccgccga caccagcacc aatatcgcct acatggaact gagcggcctg      780

cggagtgatg acaccgccgt gtactattgc gccagagtgc tggaagatga cttctggggc      840

ggctactacg acttctactt ctacgtgatg gacgtgtggg gccagggcac actggttaca      900

gtttctagcg gaggcggagg atctggtggc ggaggaagtg gcggaggcgg ttctgctctt      960

tctagcgagc tgacccagga tccagtggtg tctgttcctc tgggccagac cgccagaatt     1020

acctgtcagg gcgatagcct gaccacctac tacgccacct ggtatcagca gaagccaggc     1080

caggctcctg tgctggtgct gtacaatgag cacaagaggc ccagcggcat cagcgacaga     1140

ttttctggat cttctgccgg cgacgccgcc agcctgacaa tcacagatac acaggccgag     1200

gacgaggccg actactactg cagctctaga gataccggcg gcaaacacgt gctgtttgga     1260

ggcggcacaa agctgacagt gct                                             1283


<210>  107
<211>  1254
<212>  DNA
<213>  Artificial sequence

<220>
<223>  LgBiT_PRSIM_75

<400>  107
atggtcttca cactcgaaga tttcgttggg gactgggaac agacagccgc ctacaacctg       60

gaccaagtcc ttgaacaggg aggtgtgtcc agtttgctgc agaatctcgc cgtgtccgta      120

actccgatcc aaaggattgt ccggagcggt gaaaatgccc tgaagatcga catccatgtc      180

atcatcccgt atgaaggtct gagcgccgac caaatggccc agatcgaaga ggtgtttaag      240

gtggtgtacc ctgtggatga tcatcacttt aaggtgatcc tgccctatgg cacactggta      300

atcgacgggg ttacgccgaa catgctgaac tatttcggac ggccgtatga aggcatcgcc      360

gtgttcgacg gcaaaaagat cactgtaaca gggaccctgt ggaacggcaa caaaattatc      420

gacgagcgcc tgatcacccc cgacggctcc atgctgttcc gagtaaccat caacagtggg      480

agttccggtg gtggcgggag cggaggtgga ggctcgagcg gtgaagtgca gctggttcag      540

tctggcgccg aagtgaagaa acctggcagc agcgtgaagg tgtcctgcaa agcttctggc      600

ggcagcttca acagctacac cctggactgg gttcgacagg cccctggaca aggactggaa      660

tggatgggcg gaatcatccc cgtgttcggc agccctaatt acggccagaa attccagggc      720

agagtgacca tcaccgccga cgagtctaca agcaccgcct acatggaact gagcagcctg      780

aagtccgacg acaccgccgt gtactattgt gccagaggcc tggtgtacca gccactggat      840

tcttggggca gaggcaccct ggtcacagtt tctagcggag gcggaggatc tggtggcgga      900

ggaagtggcg gaggcggttc tgctcaagct gttctgacac agcctagcag cgcctctgga      960

acacctggcc agagagtgac aatcagctgt agcggcagca gcagcaacat cggctcctac     1020

accgtgaact ggtatcagca gttccccggc acagccccta agctgctgat ctacagcaac     1080

acccagaggc caagcggcgt gcccgataga ttttctggca gcaagagcgg cacaagcgcc     1140

agcctggcta tttctggact gcagagcgag gacgaggccg actattattg tgccgcctgg     1200

gacgacagcc tgaacggatg ggttttcggc ggaggcacca aagtgacagt gctt           1254


<210>  108
<211>  1209
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HCV-Pro - AD fusion

<400>  108
atgggcaaga aaaagggcag cgtggtcatc gtgggcagaa tcaacctgag cggcgatacc       60

gcctacgctc agcagacaag aggcgaggaa ggctgccaag agacaagcca gaccggcaga      120

gacaagaacc aggtggaagg cgaggtgcag atcgtgtcta cagctaccca gaccttcctg      180

gccaccagca tcaatggcgt gctgtggaca gtgtatcacg gcgctggcac cagaacaatc      240

gcctctccaa agggccccgt gacacagatg tacaccaacg tggacaagga cctcgtcgga      300

tggcaagccc ctcagggctc tagaagcctg acaccttgta cctgcggcag cagcgatctg      360

tacctggtca caagacacgc cgacgtgatc cccgtcagaa gaagaggcga tagcagaggc      420

agcctgctga gccctagacc tatcagctac ctgaagggat ctgccggcgg acctctgctt      480

tgtcctgctg gacatgccgt gggcatcttt agagccgccg tgtctactag aggcgtggcc      540

aaagccgtgg acttcatccc tgtggaaagc ctggaaacca ccatgagaag ccccaccggt      600

ggcggaggat ctggcggagg cggatctgat gaatttccca ccatggtgtt tccttctggg      660

cagatcagcc aggcctcggc cttggccccg gcccctcccc aagtcctgcc ccaggctcca      720

gcccctgccc ctgctccagc catggtatca gctctggccc aggccccagc ccctgtccca      780

gtcctagccc caggccctcc tcaggctgtg gccccacctg cccccaagcc cacccaggct      840

ggggaaggaa cgctgtcaga ggccctgctg cagctgcagt ttgatgatga agacctgggg      900

gccttgcttg gcaacagcac agacccagct gtgttcacag acctggcatc cgtcgacaac      960

tccgagtttc agcagctgct gaaccagggc atacctgtgg ccccccacac aactgagccc     1020

atgctgatgg agtaccctga ggctataact cgcctagtga caggggccca gaggcccccc     1080

gacccagctc ctgctccact gggggccccg gggctcccca atggcctcct ttcaggagat     1140

gaagacttct cctccattgc ggacatggac ttctcagccc tgctgagtca gatcagctcc     1200

actagttat                                                             1209


<210>  109
<211>  966
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DBD - HCV Pro fusion

<400>  109
tctagagaac gcccatatgc ttgccctgtc gagtcctgcg atcgccgctt ttctcgctcg       60

gatgagctta cccgccatat ccgcatccac acaggccaga agcccttcca gtgtcgaatc      120

tgcatgcgta acttcagtcg tagtgaccac cttaccaccc acatccgcac ccacacaggc      180

ggcggccgca ggaggaagaa acgcaccagc atagagacca acatccgtgt ggccttagag      240

aagagtttct tggagaatca aaagcctacc tcggaagaga tcactatgat tgctgatcag      300

ctcaatatgg aaaaagaggt gattcgtgtt tggttctgta accgccgcca gaaagaaaaa      360

agaatcaaca ctagcgctaa gaaaaagggc agcgtggtca tcgtgggcag aatcaacctg      420

agcggcgata ccgcctacgc tcagcagaca agaggcgagg aaggctgcca agagacaagc      480

cagaccggca gagacaagaa ccaggtggaa ggcgaggtgc agatcgtgtc tacagctacc      540

cagaccttcc tggccaccag catcaatggc gtgctgtgga cagtgtatca cggcgctggc      600

accagaacaa tcgcctctcc aaagggcccc gtgacacaga tgtacaccaa cgtggacaag      660

gacctcgtcg gatggcaagc ccctcagggc tctagaagcc tgacaccttg tacctgcggc      720

agcagcgatc tgtacctggt cacaagacac gccgacgtga tccccgtcag aagaagaggc      780

gatagcagag gcagcctgct gagccctaga cctatcagct acctgaaggg atctgccggc      840

ggacctctgc tttgtcctgc tggacatgcc gtgggcatct ttagagccgc cgtgtctact      900

agaggcgtgg ccaaagccgt ggacttcatc cctgtggaaa gcctggaaac caccatgaga      960

agccct                                                                 966


<210>  110
<211>  675
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_23_DBD_fusion

<400>  110
tctagagaac gcccatatgc ttgccctgtc gagtcctgcg atcgccgctt ttctcgctcg       60

gatgagctta cccgccatat ccgcatccac acaggccaga agcccttcca gtgtcgaatc      120

tgcatgcgta acttcagtcg tagtgaccac cttaccaccc acatccgcac ccacacaggc      180

ggcggccgca ggaggaagaa acgcaccagc atagagacca acatccgtgt ggccttagag      240

aagagtttct tggagaatca aaagcctacc tcggaagaga tcactatgat tgctgatcag      300

ctcaatatgg aaaaagaggt gattcgtgtt tggttctgta accgccgcca gaaagaaaaa      360

agaatcaaca ctagcgctgg ctctagactg gatgccccta gccagatcga agtgaaggac      420

gtgaccgaca ccaccgctct gatcacctgg gttgacccca gatacgacga catctggtgg      480

ttcgagctga cctacggcat caaggatgtg cccggcgaca gaaccaccat caagctgtac      540

ctgaacgacc cctactacag catcggcaac ctgaagcctg acaccgagta cgaggtgtcc      600

ctgatcagct acaccggcga ctcctacagc agaagcggca gcaatcctgc caagatcacc      660

ttcaagaccg gcctt                                                       675


<210>  111
<211>  681
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_32_DBD_fusion

<400>  111
tctagagaac gcccatatgc ttgccctgtc gagtcctgcg atcgccgctt ttctcgctcg       60

gatgagctta cccgccatat ccgcatccac acaggccaga agcccttcca gtgtcgaatc      120

tgcatgcgta acttcagtcg tagtgaccac cttaccaccc acatccgcac ccacacaggc      180

ggcggccgca ggaggaagaa acgcaccagc atagagacca acatccgtgt ggccttagag      240

aagagtttct tggagaatca aaagcctacc tcggaagaga tcactatgat tgctgatcag      300

ctcaatatgg aaaaagaggt gattcgtgtt tggttctgta accgccgcca gaaagaaaaa      360

agaatcaaca ctagcgctgg ctctagactg gatgccccta gccagatcga agtgaaggac      420

gtgaccgaca ccaccgctct gatcacatgg tggtccccac ggtactacta cgccagcatc      480

agcggcttcg agctgaccta cggcatcaag gatgtgcccg gcgacagaac caccatcaag      540

ctggactacg cctccaacga ctacagcatc ggcaacctga agcctgacac cgagtacgag      600

gtgtccctga tcagctggaa ctacggcgat tggcggtaca gcagcagcaa ccctgccaag      660

atcaccttca agaccggcct t                                                681


<210>  112
<211>  681
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_33_DBD_fusion

<400>  112
tctagagaac gcccatatgc ttgccctgtc gagtcctgcg atcgccgctt ttctcgctcg       60

gatgagctta cccgccatat ccgcatccac acaggccaga agcccttcca gtgtcgaatc      120

tgcatgcgta acttcagtcg tagtgaccac cttaccaccc acatccgcac ccacacaggc      180

ggcggccgca ggaggaagaa acgcaccagc atagagacca acatccgtgt ggccttagag      240

aagagtttct tggagaatca aaagcctacc tcggaagaga tcactatgat tgctgatcag      300

ctcaatatgg aaaaagaggt gattcgtgtt tggttctgta accgccgcca gaaagaaaaa      360

agaatcaaca ctagcgctgg ctctagactg gatgccccta gccagatcga agtgaaggac      420

gtgaccgaca ccaccgctct gatcacctgg tatccacctg gccgttggta cgacgacatc      480

tggtacttcg agctgaccta cggcatcaag gacgtgcccg gcgatagaac caccatcaaa      540

ctggccagag gcgacgacgt gtacagcatc ggcaacctga agcctgacac cgagtacgag      600

gtgtccctga tctcttgggg ccctgacaga ggcgatagag ccggatctaa ccccgccaag      660

atcaccttca agaccggcct t                                                681


<210>  113
<211>  681
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_36_DBD_fusion

<400>  113
tctagagaac gcccatatgc ttgccctgtc gagtcctgcg atcgccgctt ttctcgctcg       60

gatgagctta cccgccatat ccgcatccac acaggccaga agcccttcca gtgtcgaatc      120

tgcatgcgta acttcagtcg tagtgaccac cttaccaccc acatccgcac ccacacaggc      180

ggcggccgca ggaggaagaa acgcaccagc atagagacca acatccgtgt ggccttagag      240

aagagtttct tggagaatca aaagcctacc tcggaagaga tcactatgat tgctgatcag      300

ctcaatatgg aaaaagaggt gattcgtgtt tggttctgta accgccgcca gaaagaaaaa      360

agaatcaaca ctagcgctgg ctctagactg gatgccccta gccagatcga agtgaaggac      420

gtgaccgaca ccaccgctct gatcacctgg tcctggccta gagatgacga ctacgacatc      480

tggtacttcg agctgaccta cggcatcaag gacgtgcccg gcgatagaac caccatcaag      540

ctgctgaact acgcctctcc atacagcatc ggcaacctga agcctgacac cgagtacgag      600

gtgtccctga tcagcgtggt gcccgacaca tatggcagag gcacaagcaa ccccgccaag      660

atcaccttca agaccggact t                                                681


<210>  114
<211>  672
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_47_DBD_fusion

<400>  114
tctagagaac gcccatatgc ttgccctgtc gagtcctgcg atcgccgctt ttctcgctcg       60

gatgagctta cccgccatat ccgcatccac acaggccaga agcccttcca gtgtcgaatc      120

tgcatgcgta acttcagtcg tagtgaccac cttaccaccc acatccgcac ccacacaggc      180

ggcggccgca ggaggaagaa acgcaccagc atagagacca acatccgtgt ggccttagag      240

aagagtttct tggagaatca aaagcctacc tcggaagaga tcactatgat tgctgatcag      300

ctcaatatgg aaaaagaggt gattcgtgtt tggttctgta accgccgcca gaaagaaaaa      360

agaatcaaca ctagcgctgg ctctagactg gatgccccta gccagatcga agtgaaggac      420

gtgaccgaca ccaccgctct gatcacctgg tcaagacctg gcgtgtccat ctggtacttc      480

gagctgacct acggcatcaa ggacgtgccc ggcgatagaa ccaccatcaa gctggactac      540

cgcagctact actacagcat cggcaacctg aagcctgaca ccgagtacga ggtgtccctg      600

atcagcggct cttatggcct cgtgggcgtc agagcctcta atcccgccaa gatcaccttt      660

aagaccggcc tt                                                          672


<210>  115
<211>  1113
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_01_DBD_fusion

<400>  115
tctagagaac gcccatatgc ttgccctgtc gagtcctgcg atcgccgctt ttctcgctcg       60

gatgagctta cccgccatat ccgcatccac acaggccaga agcccttcca gtgtcgaatc      120

tgcatgcgta acttcagtcg tagtgaccac cttaccaccc acatccgcac ccacacaggc      180

ggcggccgca ggaggaagaa acgcaccagc atagagacca acatccgtgt ggccttagag      240

aagagtttct tggagaatca aaagcctacc tcggaagaga tcactatgat tgctgatcag      300

ctcaatatgg aaaaagaggt gattcgtgtt tggttctgta accgccgcca gaaagaaaaa      360

agaatcaaca ctagcgctgg ctctcagctg gttcagtctg gcgccgaagt gaagaaacct      420

ggcagcagcg tgaaggtgtc ctgcaaagct tctggcggca ccttcagcag ctacgccatc      480

tcttgggttc gacaggcccc tggacaaggc ctggaatgga tgggaggcat catccccatc      540

ttcggcaccg ccaattacgc ccagaaattc cagggcagag tgaccatcac cgccgacgag      600

tctacaagca ccgcctacat ggaactgagc agcctgagaa gcgaggacac cgccgtgtac      660

tattgtgcca gaggccaggg ctactacggc tacttcgatt attggggcca gggcaccctg      720

gtcacagttt ctagcggagg cggaggatct ggtggcggag gaagtggcgg aggcggttct      780

gctcaatctg tgctgacaca gcctcctagc gcctctggaa cacctggcca gagagtgaca      840

atcagctgta gcggcagcag cagcaacatc ggcagcaaca ccgtgaactg gtatcagcag      900

ctgcctggca cagcccctaa actgctgatc tacagcaaca accagcggcc tagcggcgtg      960

cccgatagat tttccgtgtc taagagcggc accagcgcca gcctggctat ttctggactg     1020

cagagcgagg acgaggccga ctattattgt gccgcctggg atcacggaca cgagcacgtt     1080

gtgtttggag gcggcaccaa gctgacagtg ctt                                  1113


<210>  116
<211>  1119
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_04_DBD_fusion

<400>  116
tctagagaac gcccatatgc ttgccctgtc gagtcctgcg atcgccgctt ttctcgctcg       60

gatgagctta cccgccatat ccgcatccac acaggccaga agcccttcca gtgtcgaatc      120

tgcatgcgta acttcagtcg tagtgaccac cttaccaccc acatccgcac ccacacaggc      180

ggcggccgca ggaggaagaa acgcaccagc atagagacca acatccgtgt ggccttagag      240

aagagtttct tggagaatca aaagcctacc tcggaagaga tcactatgat tgctgatcag      300

ctcaatatgg aaaaagaggt gattcgtgtt tggttctgta accgccgcca gaaagaaaaa      360

agaatcaaca ctagcgctgg ctctcaggtg cagcttgttc agtctggcgc cgaagtgaag      420

aaacccggca gctctgtgaa ggtgtcctgc aaagcttccg gcggcacctt tagcagctac      480

gccatctctt gggtccgaca ggctcctgga caaggcctgg aatggatggg cggcatcatc      540

cctatcttcg gcaccgccaa ttacgcccag aaattccagg gcagagtgac catcaccgcc      600

gacgagtcta caagcaccgc ctacatggaa ctgagcagcc tgagaagcga ggacaccgcc      660

gtgtactatt gcgccagagg catggcccac ttctaccagt ttgatctgtg gggccagggc      720

accctggtca cagtttctag cggaggcgga ggatctggcg gcggaggtag tggtggtggc      780

ggatctgctc agtctgtgct gacacagcct cctagcgcct ctggaacacc tggccagaga      840

gtgacaatca gctgtagcgg cagcagcagc aacatcggca gcaacaccgt gaactggtat      900

cagcagctgc ctggcacagc ccctaaactg ctgatctaca gcaacaacca gcggcctagc      960

ggcgtgcccg atagattttc tggcagcaag agcggcacaa gcgccagcct ggctatttct     1020

ggactgcaga gcgaggacga ggccgactac tattgtgctg ccggcgatca cgaccacgag     1080

cacgttgtgt ttggcggagg caccaagctg acagtgctt                            1119


<210>  117
<211>  1119
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_57_DBD_fusion

<400>  117
tctagagaac gcccatatgc ttgccctgtc gagtcctgcg atcgccgctt ttctcgctcg       60

gatgagctta cccgccatat ccgcatccac acaggccaga agcccttcca gtgtcgaatc      120

tgcatgcgta acttcagtcg tagtgaccac cttaccaccc acatccgcac ccacacaggc      180

ggcggccgca ggaggaagaa acgcaccagc atagagacca acatccgtgt ggccttagag      240

aagagtttct tggagaatca aaagcctacc tcggaagaga tcactatgat tgctgatcag      300

ctcaatatgg aaaaagaggt gattcgtgtt tggttctgta accgccgcca gaaagaaaaa      360

agaatcaaca ctagcgctgg ctctcaggtt cagctggttc agtctggcgc cgaagtgaag      420

aaacctggca gcagcgtgaa ggtgtcctgc aaagcttctg gcggcacctt cagcagctac      480

gccatctctt gggttcgaca ggcccctgga caaggcctgg aatggatggg aggcatcatc      540

cccatcttcg gcaccgccaa ttacgcccag aaattccagg gcagagtgac catcaccgcc      600

gacgagtcta caagcaccgc ctacatggaa ctgagcagcc tgagaagcga ggacaccgcc      660

gtgtactact gtgccagaca caccaactac atcaccgtgt tcgactactg gggccagggc      720

acactggtca cagtttctag cggaggcgga ggatctggtg gcggaggaag tggcggaggc      780

ggttctgctc aatctgtgct gacacagcct cctagcgcct ctggaacacc tggccagaga      840

gtgacaatca gctgtagcgg cagcagcagc aacatcggca gcaacaccgt gaactggtat      900

cagcagctgc ctggcacagc ccctaaactg ctgatctaca gcaacaacca gcggcctagc      960

ggcgtgcccg atagattttc tggcagcaag agcggcacaa gcgccagcct ggctatttct     1020

ggactgcaga gcgaggacga ggccgactat tattgtgccg cctgggacca ccactgggag     1080

caagttgttt ttggaggcgg caccaagctg accgtgctt                            1119


<210>  118
<211>  1119
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_67_DBD_fusion

<400>  118
tctagagaac gcccatatgc ttgccctgtc gagtcctgcg atcgccgctt ttctcgctcg       60

gatgagctta cccgccatat ccgcatccac acaggccaga agcccttcca gtgtcgaatc      120

tgcatgcgta acttcagtcg tagtgaccac cttaccaccc acatccgcac ccacacaggc      180

ggcggccgca ggaggaagaa acgcaccagc atagagacca acatccgtgt ggccttagag      240

aagagtttct tggagaatca aaagcctacc tcggaagaga tcactatgat tgctgatcag      300

ctcaatatgg aaaaagaggt gattcgtgtt tggttctgta accgccgcca gaaagaaaaa      360

agaatcaaca ctagcgctgg ctctgaagtg cagctggttc agtctggcgc cgaagtgaag      420

aaacctggcg ccgctgtcag aatcagctgc aagacaagcg gctacgtgtt caccagctac      480

tacgtgcact gggtccgaca ggctccagga caaggactgg aatggatggg cgtgatcaat      540

cccagcggcg gcaacaccaa ttacgcccag aaattccagg accgcgtgac catgaccaga      600

gacaccagca ccaccaccgt gtacatggaa ctgagcagcc tgatgttcga cgacaccgcc      660

gtgtactact gcgccaagag agattacggc ggacccctgg ccaattgggg cagaggaaca      720

ctggtcacag tgtctagcgg aggcggagga tctggtggcg gaggaagtgg cggaggcggt      780

tctgctctga gctatgagct gacacagcct ccaagcgtgt ccgaggctcc tagacagaga      840

gtgaccatca gctgtagcgg cagcagcagc aacatcggca acaacgccgt gaactggtat      900

cagcagctgc ctggcaaggc ccctaaactg ctgatcttct acgacgacct gctgcctagc      960

ggagtgtccg atagattcag cggctctaag agcggcacat ctgccagcct ggccatctct     1020

ggactgcaga gcgaagatga ggccgactac tattgcgccg cctgggacga ttctctgaac     1080

ggcctggttt ttggcaccgg caccaagctg acagtgctt                            1119


<210>  119
<211>  1146
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_72_DBD_fusion

<400>  119
tctagagaac gcccatatgc ttgccctgtc gagtcctgcg atcgccgctt ttctcgctcg       60

gatgagctta cccgccatat ccgcatccac acaggccaga agcccttcca gtgtcgaatc      120

tgcatgcgta acttcagtcg tagtgaccac cttaccaccc acatccgcac ccacacaggc      180

ggcggccgca ggaggaagaa acgcaccagc atagagacca acatccgtgt ggccttagag      240

aagagtttct tggagaatca aaagcctacc tcggaagaga tcactatgat tgctgatcag      300

ctcaatatgg aaaaagaggt gattcgtgtt tggttctgta accgccgcca gaaagaaaaa      360

agaatcaaca ctagcgctgg ctctcaggtt cagctggttc agtctggcgc cgaagtgaag      420

aaacctggca gcagcgtgaa ggtgtcctgc aaagtgtctg gcggcagctt caacaactac      480

ggcgtgtcct gggttcgaca ggcccctgga caaggactgg aatggatggg cagaatcatc      540

cccatccggg acaccgccaa ttacgcccag aaattccagg gcagagtgac catcaccgcc      600

gacaccagca ccaatatcgc ctacatggaa ctgagcggcc tgcggagtga tgacaccgcc      660

gtgtactatt gcgccagagt gctggaagat gacttctggg gcggctacta cgacttctac      720

ttctacgtga tggacgtgtg gggccagggc acactggtta cagtttctag cggaggcgga      780

ggatctggtg gcggaggaag tggcggaggc ggttctgctc tttctagcga gctgacccag      840

gatccagtgg tgtctgttcc tctgggccag accgccagaa ttacctgtca gggcgatagc      900

ctgaccacct actacgccac ctggtatcag cagaagccag gccaggctcc tgtgctggtg      960

ctgtacaatg agcacaagag gcccagcggc atcagcgaca gattttctgg atcttctgcc     1020

ggcgacgccg ccagcctgac aatcacagat acacaggccg aggacgaggc cgactactac     1080

tgcagctcta gagataccgg cggcaaacac gtgctgtttg gaggcggcac aaagctgaca     1140

gtgctt                                                                1146


<210>  120
<211>  1116
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_75_DBD_fusion

<400>  120
tctagagaac gcccatatgc ttgccctgtc gagtcctgcg atcgccgctt ttctcgctcg       60

gatgagctta cccgccatat ccgcatccac acaggccaga agcccttcca gtgtcgaatc      120

tgcatgcgta acttcagtcg tagtgaccac cttaccaccc acatccgcac ccacacaggc      180

ggcggccgca ggaggaagaa acgcaccagc atagagacca acatccgtgt ggccttagag      240

aagagtttct tggagaatca aaagcctacc tcggaagaga tcactatgat tgctgatcag      300

ctcaatatgg aaaaagaggt gattcgtgtt tggttctgta accgccgcca gaaagaaaaa      360

agaatcaaca ctagcgctgg ctctgaagtg cagctggttc agtctggcgc cgaagtgaag      420

aaacctggca gcagcgtgaa ggtgtcctgc aaagcttctg gcggcagctt caacagctac      480

accctggact gggttcgaca ggcccctgga caaggactgg aatggatggg cggaatcatc      540

cccgtgttcg gcagccctaa ttacggccag aaattccagg gcagagtgac catcaccgcc      600

gacgagtcta caagcaccgc ctacatggaa ctgagcagcc tgaagtccga cgacaccgcc      660

gtgtactatt gtgccagagg cctggtgtac cagccactgg attcttgggg cagaggcacc      720

ctggtcacag tttctagcgg aggcggagga tctggtggcg gaggaagtgg cggaggcggt      780

tctgctcaag ctgttctgac acagcctagc agcgcctctg gaacacctgg ccagagagtg      840

acaatcagct gtagcggcag cagcagcaac atcggctcct acaccgtgaa ctggtatcag      900

cagttccccg gcacagcccc taagctgctg atctacagca acacccagag gccaagcggc      960

gtgcccgata gattttctgg cagcaagagc ggcacaagcg ccagcctggc tatttctgga     1020

ctgcagagcg aggacgaggc cgactattat tgtgccgcct gggacgacag cctgaacgga     1080

tgggttttcg gcggaggcac caaagtgaca gtgctt                               1116


<210>  121
<211>  915
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_23_AD_fusion

<400>  121
atgggctcta gactggatgc ccctagccag atcgaagtga aggacgtgac cgacaccacc       60

gctctgatca cctgggttga ccccagatac gacgacatct ggtggttcga gctgacctac      120

ggcatcaagg atgtgcccgg cgacagaacc accatcaagc tgtacctgaa cgacccctac      180

tacagcatcg gcaacctgaa gcctgacacc gagtacgagg tgtccctgat cagctacacc      240

ggcgactcct acagcagaag cggcagcaat cctgccaaga tcaccttcaa gaccggcctt      300

accggtggcg gaggatctgg cggaggcgga tctgatgaat ttcccaccat ggtgtttcct      360

tctgggcaga tcagccaggc ctcggccttg gccccggccc ctccccaagt cctgccccag      420

gctccagccc ctgcccctgc tccagccatg gtatcagctc tggcccaggc cccagcccct      480

gtcccagtcc tagccccagg ccctcctcag gctgtggccc cacctgcccc caagcccacc      540

caggctgggg aaggaacgct gtcagaggcc ctgctgcagc tgcagtttga tgatgaagac      600

ctgggggcct tgcttggcaa cagcacagac ccagctgtgt tcacagacct ggcatccgtc      660

gacaactccg agtttcagca gctgctgaac cagggcatac ctgtggcccc ccacacaact      720

gagcccatgc tgatggagta ccctgaggct ataactcgcc tagtgacagg ggcccagagg      780

ccccccgacc cagctcctgc tccactgggg gccccggggc tccccaatgg cctcctttca      840

ggagatgaag acttctcctc cattgcggac atggacttct cagccctgct gagtcagatc      900

agctccacta gttat                                                       915


<210>  122
<211>  921
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_32_AD_fusion

<400>  122
atgggctcta gactggatgc ccctagccag atcgaagtga aggacgtgac cgacaccacc       60

gctctgatca catggtggtc cccacggtac tactacgcca gcatcagcgg cttcgagctg      120

acctacggca tcaaggatgt gcccggcgac agaaccacca tcaagctgga ctacgcctcc      180

aacgactaca gcatcggcaa cctgaagcct gacaccgagt acgaggtgtc cctgatcagc      240

tggaactacg gcgattggcg gtacagcagc agcaaccctg ccaagatcac cttcaagacc      300

ggcctgaccg gtggcggagg atctggcgga ggcggatctg atgaatttcc caccatggtg      360

tttccttctg ggcagatcag ccaggcctcg gccttggccc cggcccctcc ccaagtcctg      420

ccccaggctc cagcccctgc ccctgctcca gccatggtat cagctctggc ccaggcccca      480

gcccctgtcc cagtcctagc cccaggccct cctcaggctg tggccccacc tgcccccaag      540

cccacccagg ctggggaagg aacgctgtca gaggccctgc tgcagctgca gtttgatgat      600

gaagacctgg gggccttgct tggcaacagc acagacccag ctgtgttcac agacctggca      660

tccgtcgaca actccgagtt tcagcagctg ctgaaccagg gcatacctgt ggccccccac      720

acaactgagc ccatgctgat ggagtaccct gaggctataa ctcgcctagt gacaggggcc      780

cagaggcccc ccgacccagc tcctgctcca ctgggggccc cggggctccc caatggcctc      840

ctttcaggag atgaagactt ctcctccatt gcggacatgg acttctcagc cctgctgagt      900

cagatcagct ccactagtta t                                                921


<210>  123
<211>  921
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_33_AD_fusion

<400>  123
atgggctcta gactggatgc ccctagccag atcgaagtga aggacgtgac cgacaccacc       60

gctctgatca cctggtatcc acctggccgt tggtacgacg acatctggta cttcgagctg      120

acctacggca tcaaggacgt gcccggcgat agaaccacca tcaaactggc cagaggcgac      180

gacgtgtaca gcatcggcaa cctgaagcct gacaccgagt acgaggtgtc cctgatctct      240

tggggccctg acagaggcga tagagccgga tctaaccccg ccaagatcac cttcaagacc      300

ggccttaccg gtggcggagg atctggcgga ggcggatctg atgaatttcc caccatggtg      360

tttccttctg ggcagatcag ccaggcctcg gccttggccc cggcccctcc ccaagtcctg      420

ccccaggctc cagcccctgc ccctgctcca gccatggtat cagctctggc ccaggcccca      480

gcccctgtcc cagtcctagc cccaggccct cctcaggctg tggccccacc tgcccccaag      540

cccacccagg ctggggaagg aacgctgtca gaggccctgc tgcagctgca gtttgatgat      600

gaagacctgg gggccttgct tggcaacagc acagacccag ctgtgttcac agacctggca      660

tccgtcgaca actccgagtt tcagcagctg ctgaaccagg gcatacctgt ggccccccac      720

acaactgagc ccatgctgat ggagtaccct gaggctataa ctcgcctagt gacaggggcc      780

cagaggcccc ccgacccagc tcctgctcca ctgggggccc cggggctccc caatggcctc      840

ctttcaggag atgaagactt ctcctccatt gcggacatgg acttctcagc cctgctgagt      900

cagatcagct ccactagtta t                                                921


<210>  124
<211>  921
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_36_AD_fusion

<400>  124
atgggctcta gactggatgc ccctagccag atcgaagtga aggacgtgac cgacaccacc       60

gctctgatca cctggtcctg gcctagagat gacgactacg acatctggta cttcgagctg      120

acctacggca tcaaggacgt gcccggcgat agaaccacca tcaagctgct gaactacgcc      180

tctccataca gcatcggcaa cctgaagcct gacaccgagt acgaggtgtc cctgatcagc      240

gtggtgcccg acacatatgg cagaggcaca agcaaccccg ccaagatcac cttcaagacc      300

ggacttaccg gtggcggagg atctggcgga ggcggatctg atgaatttcc caccatggtg      360

tttccttctg ggcagatcag ccaggcctcg gccttggccc cggcccctcc ccaagtcctg      420

ccccaggctc cagcccctgc ccctgctcca gccatggtat cagctctggc ccaggcccca      480

gcccctgtcc cagtcctagc cccaggccct cctcaggctg tggccccacc tgcccccaag      540

cccacccagg ctggggaagg aacgctgtca gaggccctgc tgcagctgca gtttgatgat      600

gaagacctgg gggccttgct tggcaacagc acagacccag ctgtgttcac agacctggca      660

tccgtcgaca actccgagtt tcagcagctg ctgaaccagg gcatacctgt ggccccccac      720

acaactgagc ccatgctgat ggagtaccct gaggctataa ctcgcctagt gacaggggcc      780

cagaggcccc ccgacccagc tcctgctcca ctgggggccc cggggctccc caatggcctc      840

ctttcaggag atgaagactt ctcctccatt gcggacatgg acttctcagc cctgctgagt      900

cagatcagct ccactagtta t                                                921


<210>  125
<211>  912
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_47_AD_fusion

<400>  125
atgggctcta gactggatgc ccctagccag atcgaagtga aggacgtgac cgacaccacc       60

gctctgatca cctggtcaag acctggcgtg tccatctggt acttcgagct gacctacggc      120

atcaaggacg tgcccggcga tagaaccacc atcaagctgg actaccgcag ctactactac      180

agcatcggca acctgaagcc tgacaccgag tacgaggtgt ccctgatcag cggctcttat      240

ggcctcgtgg gcgtcagagc ctctaatccc gccaagatca cctttaagac cggccttacc      300

ggtggcggag gatctggcgg aggcggatct gatgaatttc ccaccatggt gtttccttct      360

gggcagatca gccaggcctc ggccttggcc ccggcccctc cccaagtcct gccccaggct      420

ccagcccctg cccctgctcc agccatggta tcagctctgg cccaggcccc agcccctgtc      480

ccagtcctag ccccaggccc tcctcaggct gtggccccac ctgcccccaa gcccacccag      540

gctggggaag gaacgctgtc agaggccctg ctgcagctgc agtttgatga tgaagacctg      600

ggggccttgc ttggcaacag cacagaccca gctgtgttca cagacctggc atccgtcgac      660

aactccgagt ttcagcagct gctgaaccag ggcatacctg tggcccccca cacaactgag      720

cccatgctga tggagtaccc tgaggctata actcgcctag tgacaggggc ccagaggccc      780

cccgacccag ctcctgctcc actgggggcc ccggggctcc ccaatggcct cctttcagga      840

gatgaagact tctcctccat tgcggacatg gacttctcag ccctgctgag tcagatcagc      900

tccactagtt at                                                          912


<210>  126
<211>  1359
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_01_AD_fusion

<400>  126
atgggctctc aggttcagct ggttcagtct ggcgccgaag tgaagaaacc tggcagcagc       60

gtgaaggtgt cctgcaaagc ttctggcggc accttcagca gctacgccat ctcttgggtt      120

cgacaggccc ctggacaagg cctggaatgg atgggaggca tcatccccat cttcggcacc      180

gccaattacg cccagaaatt ccagggcaga gtgaccatca ccgccgacga gtctacaagc      240

accgcctaca tggaactgag cagcctgaga agcgaggaca ccgccgtgta ctattgtgcc      300

agaggccagg gctactacgg ctacttcgat tattggggcc agggcaccct ggtcacagtt      360

tctagcggag gcggaggatc tggtggcgga ggaagtggcg gaggcggttc tgctcaatct      420

gtgctgacac agcctcctag cgcctctgga acacctggcc agagagtgac aatcagctgt      480

agcggcagca gcagcaacat cggcagcaac accgtgaact ggtatcagca gctgcctggc      540

acagccccta aactgctgat ctacagcaac aaccagcggc ctagcggcgt gcccgataga      600

ttttccgtgt ctaagagcgg caccagcgcc agcctggcta tttctggact gcagagcgag      660

gacgaggccg actattattg tgccgcctgg gatcacggac acgagcacgt tgtgtttgga      720

ggcggcacca agctgacagt gcttaccggt ggcggaggat ctggcggagg cggatctgat      780

gaatttccca ccatggtgtt tccttctggg cagatcagcc aggcctcggc cttggccccg      840

gcccctcccc aagtcctgcc ccaggctcca gcccctgccc ctgctccagc catggtatca      900

gctctggccc aggccccagc ccctgtccca gtcctagccc caggccctcc tcaggctgtg      960

gccccacctg cccccaagcc cacccaggct ggggaaggaa cgctgtcaga ggccctgctg     1020

cagctgcagt ttgatgatga agacctgggg gccttgcttg gcaacagcac agacccagct     1080

gtgttcacag acctggcatc cgtcgacaac tccgagtttc agcagctgct gaaccagggc     1140

atacctgtgg ccccccacac aactgagccc atgctgatgg agtaccctga ggctataact     1200

cgcctagtga caggggccca gaggcccccc gacccagctc ctgctccact gggggccccg     1260

gggctcccca atggcctcct ttcaggagat gaagacttct cctccattgc ggacatggac     1320

ttctcagccc tgctgagtca gatcagctcc actagttat                            1359


<210>  127
<211>  1359
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_04_AD_fusion

<400>  127
atgggctctc aggtgcagct tgttcagtct ggcgccgaag tgaagaaacc cggcagctct       60

gtgaaggtgt cctgcaaagc ttccggcggc acctttagca gctacgccat ctcttgggtc      120

cgacaggctc ctggacaagg cctggaatgg atgggcggca tcatccctat cttcggcacc      180

gccaattacg cccagaaatt ccagggcaga gtgaccatca ccgccgacga gtctacaagc      240

accgcctaca tggaactgag cagcctgaga agcgaggaca ccgccgtgta ctattgcgcc      300

agaggcatgg cccacttcta ccagtttgat ctgtggggcc agggcaccct ggtcacagtt      360

tctagcggag gcggaggatc tggcggcgga ggtagtggtg gtggcggatc tgctcagtct      420

gtgctgacac agcctcctag cgcctctgga acacctggcc agagagtgac aatcagctgt      480

agcggcagca gcagcaacat cggcagcaac accgtgaact ggtatcagca gctgcctggc      540

acagccccta aactgctgat ctacagcaac aaccagcggc ctagcggcgt gcccgataga      600

ttttctggca gcaagagcgg cacaagcgcc agcctggcta tttctggact gcagagcgag      660

gacgaggccg actactattg tgctgccggc gatcacgacc acgagcacgt tgtgtttggc      720

ggaggcacca agctgacagt gcttaccggt ggcggaggat ctggcggagg cggatctgat      780

gaatttccca ccatggtgtt tccttctggg cagatcagcc aggcctcggc cttggccccg      840

gcccctcccc aagtcctgcc ccaggctcca gcccctgccc ctgctccagc catggtatca      900

gctctggccc aggccccagc ccctgtccca gtcctagccc caggccctcc tcaggctgtg      960

gccccacctg cccccaagcc cacccaggct ggggaaggaa cgctgtcaga ggccctgctg     1020

cagctgcagt ttgatgatga agacctgggg gccttgcttg gcaacagcac agacccagct     1080

gtgttcacag acctggcatc cgtcgacaac tccgagtttc agcagctgct gaaccagggc     1140

atacctgtgg ccccccacac aactgagccc atgctgatgg agtaccctga ggctataact     1200

cgcctagtga caggggccca gaggcccccc gacccagctc ctgctccact gggggccccg     1260

gggctcccca atggcctcct ttcaggagat gaagacttct cctccattgc ggacatggac     1320

ttctcagccc tgctgagtca gatcagctcc actagttat                            1359


<210>  128
<211>  1359
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_57_AD_fusion

<400>  128
atgggctctc aggttcagct ggttcagtct ggcgccgaag tgaagaaacc tggcagcagc       60

gtgaaggtgt cctgcaaagc ttctggcggc accttcagca gctacgccat ctcttgggtt      120

cgacaggccc ctggacaagg cctggaatgg atgggaggca tcatccccat cttcggcacc      180

gccaattacg cccagaaatt ccagggcaga gtgaccatca ccgccgacga gtctacaagc      240

accgcctaca tggaactgag cagcctgaga agcgaggaca ccgccgtgta ctactgtgcc      300

agacacacca actacatcac cgtgttcgac tactggggcc agggcacact ggtcacagtt      360

tctagcggag gcggaggatc tggtggcgga ggaagtggcg gaggcggttc tgctcaatct      420

gtgctgacac agcctcctag cgcctctgga acacctggcc agagagtgac aatcagctgt      480

agcggcagca gcagcaacat cggcagcaac accgtgaact ggtatcagca gctgcctggc      540

acagccccta aactgctgat ctacagcaac aaccagcggc ctagcggcgt gcccgataga      600

ttttctggca gcaagagcgg cacaagcgcc agcctggcta tttctggact gcagagcgag      660

gacgaggccg actattattg tgccgcctgg gaccaccact gggagcaagt tgtttttgga      720

ggcggcacca agctgaccgt gcttaccggt ggcggaggat ctggcggagg cggatctgat      780

gaatttccca ccatggtgtt tccttctggg cagatcagcc aggcctcggc cttggccccg      840

gcccctcccc aagtcctgcc ccaggctcca gcccctgccc ctgctccagc catggtatca      900

gctctggccc aggccccagc ccctgtccca gtcctagccc caggccctcc tcaggctgtg      960

gccccacctg cccccaagcc cacccaggct ggggaaggaa cgctgtcaga ggccctgctg     1020

cagctgcagt ttgatgatga agacctgggg gccttgcttg gcaacagcac agacccagct     1080

gtgttcacag acctggcatc cgtcgacaac tccgagtttc agcagctgct gaaccagggc     1140

atacctgtgg ccccccacac aactgagccc atgctgatgg agtaccctga ggctataact     1200

cgcctagtga caggggccca gaggcccccc gacccagctc ctgctccact gggggccccg     1260

gggctcccca atggcctcct ttcaggagat gaagacttct cctccattgc ggacatggac     1320

ttctcagccc tgctgagtca gatcagctcc actagttat                            1359


<210>  129
<211>  1359
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_67_AD_fusion

<400>  129
atgggctctg aagtgcagct ggttcagtct ggcgccgaag tgaagaaacc tggcgccgct       60

gtcagaatca gctgcaagac aagcggctac gtgttcacca gctactacgt gcactgggtc      120

cgacaggctc caggacaagg actggaatgg atgggcgtga tcaatcccag cggcggcaac      180

accaattacg cccagaaatt ccaggaccgc gtgaccatga ccagagacac cagcaccacc      240

accgtgtaca tggaactgag cagcctgatg ttcgacgaca ccgccgtgta ctactgcgcc      300

aagagagatt acggcggacc cctggccaat tggggcagag gaacactggt cacagtgtct      360

agcggaggcg gaggatctgg tggcggagga agtggcggag gcggttctgc tctgagctat      420

gagctgacac agcctccaag cgtgtccgag gctcctagac agagagtgac catcagctgt      480

agcggcagca gcagcaacat cggcaacaac gccgtgaact ggtatcagca gctgcctggc      540

aaggccccta aactgctgat cttctacgac gacctgctgc ctagcggagt gtccgataga      600

ttcagcggct ctaagagcgg cacatctgcc agcctggcca tctctggact gcagagcgaa      660

gatgaggccg actactattg cgccgcctgg gacgattctc tgaacggcct ggtttttggc      720

accggcacca agctgacagt gctgaccggt ggcggaggat ctggcggagg cggatctgat      780

gaatttccca ccatggtgtt tccttctggg cagatcagcc aggcctcggc cttggccccg      840

gcccctcccc aagtcctgcc ccaggctcca gcccctgccc ctgctccagc catggtatca      900

gctctggccc aggccccagc ccctgtccca gtcctagccc caggccctcc tcaggctgtg      960

gccccacctg cccccaagcc cacccaggct ggggaaggaa cgctgtcaga ggccctgctg     1020

cagctgcagt ttgatgatga agacctgggg gccttgcttg gcaacagcac agacccagct     1080

gtgttcacag acctggcatc cgtcgacaac tccgagtttc agcagctgct gaaccagggc     1140

atacctgtgg ccccccacac aactgagccc atgctgatgg agtaccctga ggctataact     1200

cgcctagtga caggggccca gaggcccccc gacccagctc ctgctccact gggggccccg     1260

gggctcccca atggcctcct ttcaggagat gaagacttct cctccattgc ggacatggac     1320

ttctcagccc tgctgagtca gatcagctcc actagttat                            1359


<210>  130
<211>  1386
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_72_AD_fusion

<400>  130
atgggctctc aggttcagct ggttcagtct ggcgccgaag tgaagaaacc tggcagcagc       60

gtgaaggtgt cctgcaaagt gtctggcggc agcttcaaca actacggcgt gtcctgggtt      120

cgacaggccc ctggacaagg actggaatgg atgggcagaa tcatccccat ccgggacacc      180

gccaattacg cccagaaatt ccagggcaga gtgaccatca ccgccgacac cagcaccaat      240

atcgcctaca tggaactgag cggcctgcgg agtgatgaca ccgccgtgta ctattgcgcc      300

agagtgctgg aagatgactt ctggggcggc tactacgact tctacttcta cgtgatggac      360

gtgtggggcc agggcacact ggttacagtt tctagcggag gcggaggatc tggtggcgga      420

ggaagtggcg gaggcggttc tgctctttct agcgagctga cccaggatcc agtggtgtct      480

gttcctctgg gccagaccgc cagaattacc tgtcagggcg atagcctgac cacctactac      540

gccacctggt atcagcagaa gccaggccag gctcctgtgc tggtgctgta caatgagcac      600

aagaggccca gcggcatcag cgacagattt tctggatctt ctgccggcga cgccgccagc      660

ctgacaatca cagatacaca ggccgaggac gaggccgact actactgcag ctctagagat      720

accggcggca aacacgtgct gtttggaggc ggcacaaagc tgacagtgct gaccggtggc      780

ggaggatctg gcggaggcgg atctgatgaa tttcccacca tggtgtttcc ttctgggcag      840

atcagccagg cctcggcctt ggccccggcc cctccccaag tcctgcccca ggctccagcc      900

cctgcccctg ctccagccat ggtatcagct ctggcccagg ccccagcccc tgtcccagtc      960

ctagccccag gccctcctca ggctgtggcc ccacctgccc ccaagcccac ccaggctggg     1020

gaaggaacgc tgtcagaggc cctgctgcag ctgcagtttg atgatgaaga cctgggggcc     1080

ttgcttggca acagcacaga cccagctgtg ttcacagacc tggcatccgt cgacaactcc     1140

gagtttcagc agctgctgaa ccagggcata cctgtggccc cccacacaac tgagcccatg     1200

ctgatggagt accctgaggc tataactcgc ctagtgacag gggcccagag gccccccgac     1260

ccagctcctg ctccactggg ggccccgggg ctccccaatg gcctcctttc aggagatgaa     1320

gacttctcct ccattgcgga catggacttc tcagccctgc tgagtcagat cagctccact     1380

agttat                                                                1386


<210>  131
<211>  1356
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_75_AD_fusion

<400>  131
atgggctctg aagtgcagct ggttcagtct ggcgccgaag tgaagaaacc tggcagcagc       60

gtgaaggtgt cctgcaaagc ttctggcggc agcttcaaca gctacaccct ggactgggtt      120

cgacaggccc ctggacaagg actggaatgg atgggcggaa tcatccccgt gttcggcagc      180

cctaattacg gccagaaatt ccagggcaga gtgaccatca ccgccgacga gtctacaagc      240

accgcctaca tggaactgag cagcctgaag tccgacgaca ccgccgtgta ctattgtgcc      300

agaggcctgg tgtaccagcc actggattct tggggcagag gcaccctggt cacagtttct      360

agcggaggcg gaggatctgg tggcggagga agtggcggag gcggttctgc tcaagctgtt      420

ctgacacagc ctagcagcgc ctctggaaca cctggccaga gagtgacaat cagctgtagc      480

ggcagcagca gcaacatcgg ctcctacacc gtgaactggt atcagcagtt ccccggcaca      540

gcccctaagc tgctgatcta cagcaacacc cagaggccaa gcggcgtgcc cgatagattt      600

tctggcagca agagcggcac aagcgccagc ctggctattt ctggactgca gagcgaggac      660

gaggccgact attattgtgc cgcctgggac gacagcctga acggatgggt tttcggcgga      720

ggcaccaaag tgacagtgct gaccggtggc ggaggatctg gcggaggcgg atctgatgaa      780

tttcccacca tggtgtttcc ttctgggcag atcagccagg cctcggcctt ggccccggcc      840

cctccccaag tcctgcccca ggctccagcc cctgcccctg ctccagccat ggtatcagct      900

ctggcccagg ccccagcccc tgtcccagtc ctagccccag gccctcctca ggctgtggcc      960

ccacctgccc ccaagcccac ccaggctggg gaaggaacgc tgtcagaggc cctgctgcag     1020

ctgcagtttg atgatgaaga cctgggggcc ttgcttggca acagcacaga cccagctgtg     1080

ttcacagacc tggcatccgt cgacaactcc gagtttcagc agctgctgaa ccagggcata     1140

cctgtggccc cccacacaac tgagcccatg ctgatggagt accctgaggc tataactcgc     1200

ctagtgacag gggcccagag gccccccgac ccagctcctg ctccactggg ggccccgggg     1260

ctccccaatg gcctcctttc aggagatgaa gacttctcct ccattgcgga catggacttc     1320

tcagccctgc tgagtcagat cagctccact agttat                               1356


<210>  132
<211>  2592
<212>  DNA
<213>  Artificial sequence

<220>
<223>  FKBP12:FRB CAR

<400>  132
atgctgctgc tggttacatc tctgctgctg tgcgagctgc cccatcctgc ctttctgctg       60

attcctgaaa gcaaatacgg ccctccgtgt cctccttgtc ctttctgggt gctcgtggtt      120

gttggcggag tgctggcctg ttatagcctg cttgtgaccg tggccttcat catcttttgg      180

gtcaagcggg gcagaaagaa gctgctgtac atcttcaagc agcccttcat gcggcccgtg      240

cagaccacac aagaggaaga tggctgctcc tgcagattcc ccgaggaaga agaaggcggc      300

tgcgagctgt ctagaggcag cggatcaggc tctggatcta tgggcgtgca ggtcgagaca      360

atctctcctg gcgacggcag aacattcccc aagaggggcc agacatgcgt ggtgcactat      420

accggcatgc tcgaggacgg caagaagttc gacagctccc gggacagaaa caagcccttc      480

aagttcatgc tgggcaagca agaagtgatc agaggctggg aagagggcgt cgcccagatg      540

tctgttggcc agagagccaa actgacaatc agccccgatt acgcctacgg cgccacagga      600

caccctggaa tcattcctcc acacgccaca ctggtgttcg acgtggaact gctgaagctg      660

gaaggcagcg gcgccaccaa tttcagcctg ctgaaacagg ccggcgacgt cgaagagaac      720

cccggaccta tgatccacct gggccacatt ctgtttctgt tgctgctgcc tgtggccgct      780

gctcagacaa cacctggcga gagatctagc ctgcctgcct tctatcctgg caccagcggc      840

tcttgttctg gctgtggatc tctgagcctg ccagagtcta agtacggccc tccgtgtcca      900

ccatgtccat tttgggtcct cgttgtcgtc ggaggcgtgc tggcttgcta ttctctgctc      960

gtgacagtcg cctttattat cttctgggtg tccctgaaga gaggccggaa aaaactgctc     1020

tatatcttta aacagccgtt tatgcgcccg gtccagacaa cccaagaaga ggacggctgt     1080

agctgccggt ttcctgaaga agaggaaggc ggttgcgaac tgatcctgtg gcacgagatg     1140

tggcatgaag gcctggaaga ggccagcaga ctgtacttcg gcgagagaaa cgtgaaaggc     1200

atgttcgagg tgctggaacc tctgcacgcc atgatggaaa gaggccctca gacactgaaa     1260

gagacaagct tcaaccaggc ctacggccgg gatctgatgg aagcccaaga gtggtgccgg     1320

aagtacatga agtccggcaa cgtgaaggac ctgctgcagg cctgggatct gtactaccac     1380

gtgttccggc ggatcagcaa aggctccgga agcggatctg gaagctccct gagagtgaag     1440

ttcagcagaa gcgccgacgc tcctgcctat cagcagggac agaaccagct gtacaacgag     1500

ctgaacctgg ggagaagaga agagtacgac gtgctggaca agcggagagg cagagatcct     1560

gagatgggcg gcaagcccag acggaagaat cctcaagagg gcctgtataa tgagctgcag     1620

aaagacaaga tggccgaggc ctacagcgag atcggaatga agggcgagcg cagaagaggc     1680

aagggacacg atggactgta ccagggcctg agcaccgcca ccaaggatac ctatgatgcc     1740

ctgcacatgc aggccctgcc tccaagaggt agtggcgaag gcagaggctc tctgctgaca     1800

tgcggagatg tggaagagaa tcctgggcca agcggcatgg aaagcgacga atctggactc     1860

cccgccatgg aaatcgagtg cagaatcacc ggcacactga acggcgtgga attcgaactc     1920

gttggaggcg gcgagggcac acctaagcag ggcagaatga ccaacaagat gaagtccacc     1980

aaaggcgccc tgactttcag cccctacctg ctgtctcacg tgatgggcta cggcttctac     2040

cacttcggca cataccctag cggctacgag aaccccttcc tgcatgccat caacaacggc     2100

ggctacacca acaccagaat cgagaagtac gaggatggcg gcgtgctgca cgtgtccttc     2160

agctacagat atgaggccgg cagagtgatc ggcgacttca aggttgtcgg caccggcttt     2220

ccagaggaca gcgtgatctt caccgacaag atcatccggt ccaacgccac cgtcgagcat     2280

ctgcacccta tgggcgataa tgtgcttgtg ggcagcttcg ccagaacctt cagtctgcgt     2340

gatggcggct actacagctt cgtggtggac agccacatgc acttcaagag cgccatccat     2400

cctagcatcc tgcagaacgg cggacccatg ttcgccttca gaagagtgga agaactgcac     2460

tccaacaccg agctgggcat cgtggaatac cagcacgctt tcaagacccc tatcgccttc     2520

gcaagaagca gagcccagag cagcaatagc gccgtggatg gaacagccgg acctggctct     2580

acaggctcca ga                                                         2592


<210>  133
<211>  2913
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM_23 CAR

<400>  133
atgctgctgc tggttacatc tctgctgctg tgcgagctgc cccatcctgc ctttctgctg       60

attcctgaaa gcaaatacgg ccctccgtgt cctccttgtc ctttctgggt gctcgtggtt      120

gttggcggag tgctggcctg ttatagcctg cttgtgaccg tggccttcat catcttttgg      180

gtcaagcggg gcagaaagaa gctgctgtac atcttcaagc agcccttcat gcggcccgtg      240

cagaccacac aagaggaaga tggctgctcc tgcagattcc ccgaggaaga agaaggcggc      300

tgcgagctgg gtggcggagg atctggcgga ggcggatcta tgaagaaaaa gggctctgtg      360

gtcatcgtgg gcagaatcaa cctgagcggc gataccgcct acgctcagca gacaagaggc      420

gaggaaggct gccaagagac aagccagacc ggcagagaca agaaccaggt ggaaggcgag      480

gtgcagatcg tgtctacagc tacccagacc ttcctggcca ccagcatcaa tggcgtgctg      540

tggacagtgt atcacggcgc tggcaccaga acaatcgcct ctccaaaggg ccccgtgaca      600

cagatgtaca ccaacgtgga caaggacctc gtcggatggc aagcccctca gggctctaga      660

agcctgacac cttgtacctg cggcagcagc gatctgtacc tggtcacaag acacgccgac      720

gtgatccccg tcagaagaag aggcgatagc agaggcagcc tgctgagccc tagacctatc      780

agctacctga agggatctgc cggcggacct ctgctttgtc ctgctggaca tgccgtgggc      840

atctttagag ccgccgtgtc tactagaggc gtggccaagg ccgtggactt catccctgtg      900

gaaagcctgg aaaccaccat gcggagcccc ggcagcggcg ccaccaattt cagcctgctg      960

aaacaggccg gcgacgtcga agagaacccc ggacctatga tccacctggg ccacattctg     1020

tttctgttgc tgctgcctgt ggccgctgct cagacaacac ctggcgagag atctagcctg     1080

cctgccttct atcctggcac cagcggctct tgttctggct gtggatctct gagcctgcca     1140

gagtctaagt acggccctcc gtgtccacca tgtccatttt gggtcctcgt tgtcgtcgga     1200

ggcgtgctgg cttgctattc tctgctcgtg acagtcgcct ttattatctt ctgggtgtcc     1260

ctgaagagag gccggaaaaa actgctctat atctttaaac agccgtttat gcgcccggtc     1320

cagacaaccc aagaagagga cggctgtagc tgccggtttc ctgaagaaga ggaaggcggt     1380

tgcgaactgg gtggcggagg atctggcgga ggcggatcta tgggctctag actggatgcc     1440

cctagccaga tcgaagtgaa ggacgtgacc gacaccaccg ctctgatcac ctgggttgac     1500

cccagatacg acgacatctg gtggttcgag ctgacctacg gcatcaagga tgtgcccggc     1560

gacagaacca ccatcaagct gtacctgaac gacccctact acagcatcgg caacctgaag     1620

cctgacaccg agtacgaggt gtccctgatc agctacaccg gcgactccta cagcagaagc     1680

ggcagcaatc ctgccaagat caccttcaag accggccttg gtggcggagg atctggcgga     1740

ggcggatctc tgagagtgaa gttcagcaga agcgccgacg ctcctgccta tcagcaggga     1800

cagaaccagc tgtacaacga gctgaacctg gggagaagag aagagtacga cgtgctggac     1860

aagcggagag gcagagatcc tgagatgggc ggcaagccca gacggaagaa tcctcaagag     1920

ggcctgtata atgagctgca gaaagacaag atggccgagg cctacagcga gatcggaatg     1980

aagggcgagc gcagaagagg caagggacac gatggactgt accagggcct gagcaccgcc     2040

accaaggata cctatgatgc cctgcacatg caggccctgc ctccaagagg tagtggcgaa     2100

ggcagaggct ctctgctgac atgcggagat gtggaagaga atcctgggcc aagcggcatg     2160

gaaagcgacg aatctggact ccccgccatg gaaatcgagt gcagaatcac cggcacactg     2220

aacggcgtgg aattcgaact cgttggaggc ggcgagggca cacctaagca gggcagaatg     2280

accaacaaga tgaagtccac caaaggcgcc ctgactttca gcccctacct gctgtctcac     2340

gtgatgggct acggcttcta ccacttcggc acatacccta gcggctacga gaaccccttc     2400

ctgcatgcca tcaacaacgg cggctacacc aacaccagaa tcgagaagta cgaggatggc     2460

ggcgtgctgc acgtgtcctt cagctacaga tatgaggccg gcagagtgat cggcgacttc     2520

aaggttgtcg gcaccggctt tccagaggac agcgtgatct tcaccgacaa gatcatccgg     2580

tccaacgcca ccgtcgagca tctgcaccct atgggcgata atgtgcttgt gggcagcttc     2640

gccagaacct tcagtctgcg tgatggcggc tactacagct tcgtggtgga cagccacatg     2700

cacttcaaga gcgccatcca tcctagcatc ctgcagaacg gcggacccat gttcgccttc     2760

agaagagtgg aagaactgca ctccaacacc gagctgggca tcgtggaata ccagcacgct     2820

ttcaagaccc ctatcgcctt cgcaagaagc agagcccaga gcagcaatag cgccgtggat     2880

ggaacagccg gacctggctc tacaggctcc aga                                  2913


<210>  134
<211>  92
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Wild type TN3

<400>  134

Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr 
1               5                   10                  15      


Thr Ala Leu Ile Thr Trp Phe Lys Pro Leu Ala Glu Ile Asp Gly Ile 
            20                  25                  30          


Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr Ile 
        35                  40                  45              


Asp Leu Thr Glu Asp Glu Asn Gln Tyr Ser Ile Gly Asn Leu Lys Pro 
    50                  55                  60                  


Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Arg Arg Gly Asp Met Ser 
65                  70                  75                  80  


Ser Asn Pro Ala Lys Glu Thr Phe Thr Thr Gly Leu 
                85                  90          


<210>  135
<211>  92
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Wild type TN3 with stabilising mutations

<400>  135

Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr 
1               5                   10                  15      


Thr Ala Leu Ile Thr Trp Phe Lys Pro Leu Ala Glu Ile Asp Gly Phe 
            20                  25                  30          


Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr Ile 
        35                  40                  45              


Lys Leu Thr Glu Asp Glu Asn Gln Tyr Ser Ile Gly Asn Leu Lys Pro 
    50                  55                  60                  


Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Arg Arg Gly Asp Met Ser 
65                  70                  75                  80  


Ser Asn Pro Ala Lys Ile Thr Phe Lys Thr Gly Leu 
                85                  90          


<210>  136
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_23 BC loop

<400>  136

Val Asp Pro Arg Tyr Asp Asp Ile Trp Trp 
1               5                   10  


<210>  137
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_23 DE loop

<400>  137

Tyr Leu Asn Asp Pro Tyr 
1               5       


<210>  138
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_23 FG loop

<400>  138

Tyr Thr Gly Asp Ser Tyr Ser Arg Ser Gly Ser Asn Pro Ala 
1               5                   10                  


<210>  139
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_32 BC loop

<400>  139

Trp Ser Pro Arg Tyr Tyr Tyr Ala Ser Ile Ser Gly 
1               5                   10          


<210>  140
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_32 DE loop

<400>  140

Asp Tyr Ala Ser Asn Asp 
1               5       


<210>  141
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_32 FG loop

<400>  141

Trp Asn Tyr Gly Asp Trp Arg Tyr Ser Ser Ser Asn Pro Ala 
1               5                   10                  


<210>  142
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_33 BC loop

<400>  142

Tyr Pro Pro Gly Arg Trp Tyr Asp Asp Ile Trp Tyr 
1               5                   10          


<210>  143
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_33 DE loop

<400>  143

Ala Arg Gly Asp Asp Val 
1               5       


<210>  144
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_33 FG loop

<400>  144

Trp Gly Pro Asp Arg Gly Asp Arg Ala Gly Ser Asn Pro Ala 
1               5                   10                  


<210>  145
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_36 BC loop

<400>  145

Ser Trp Pro Arg Asp Asp Asp Tyr Asp Ile Trp Tyr 
1               5                   10          


<210>  146
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_36 DE loop

<400>  146

Leu Asn Tyr Ala Ser Pro 
1               5       


<210>  147
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_36 FG loop

<400>  147

Val Val Pro Asp Thr Tyr Gly Arg Gly Thr Ser Asn Pro Ala 
1               5                   10                  


<210>  148
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_47 BC loop

<400>  148

Ser Arg Pro Gly Val Ser Ile Trp Tyr 
1               5                   


<210>  149
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_47 DE loop

<400>  149

Asp Tyr Arg Ser Tyr Tyr 
1               5       


<210>  150
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_47 FG loop

<400>  150

Gly Ser Tyr Gly Leu Val Gly Val Arg Ala Ser Asn Pro Ala 
1               5                   10                  


<210>  151
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_57 HCDR1

<400>  151

Ser Tyr Ala Ile Ser 
1               5   


<210>  152
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_57 HCDR2

<400>  152

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  153
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_57 HCDR3

<400>  153

His Thr Asn Tyr Ile Thr Val Phe Asp Tyr 
1               5                   10  


<210>  154
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_57 LCDR1

<400>  154

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210>  155
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_57 LCDR2

<400>  155

Ser Asn Asn Gln Arg Pro Ser 
1               5           


<210>  156
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_57 LCDR3

<400>  156

Ala Ala Trp Asp His His Trp Glu Gln Val Val 
1               5                   10      


<210>  157

<400>  157
000

<210>  158

<400>  158
000

<210>  159

<400>  159
000

<210>  160

<400>  160
000

<210>  161

<400>  161
000

<210>  162

<400>  162
000

<210>  163
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_04 HCDR3

<400>  163

Gly Met Ala His Phe Tyr Gln Phe Asp Leu 
1               5                   10  


<210>  164
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_04 LCDR3

<400>  164

Ala Ala Gly Asp His Asp His Glu His Val Val 
1               5                   10      


<210>  165
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_67 HCDR1

<400>  165

Ser Tyr Tyr Val His 
1               5   


<210>  166
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_67 HCDR2

<400>  166

Val Ile Asn Pro Ser Gly Gly Asn Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  167
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_67 HCDR3

<400>  167

Arg Asp Tyr Gly Gly Pro Leu Ala Asn 
1               5                   


<210>  168
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_67 LCDR1

<400>  168

Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn 
1               5                   10              


<210>  169
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_67 LCDR2

<400>  169

Tyr Asp Asp Leu Leu Pro Ser 
1               5           


<210>  170
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_67 LCDR3

<400>  170

Ala Ala Trp Asp Asp Ser Leu Asn Gly Leu Val 
1               5                   10      


<210>  171
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_72 HCDR1

<400>  171

Asn Tyr Gly Val Ser 
1               5   


<210>  172
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_72 HCDR2

<400>  172

Arg Ile Ile Pro Ile Arg Asp Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  173
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_72 HCDR3

<400>  173

Val Leu Glu Asp Asp Phe Trp Gly Gly Tyr Tyr Asp Phe Tyr Phe Tyr 
1               5                   10                  15      


Val Met Asp Val 
            20  


<210>  174
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_72 LCDR1

<400>  174

Gln Gly Asp Ser Leu Thr Thr Tyr Tyr Ala Thr 
1               5                   10      


<210>  175
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_72 LCDR2

<400>  175

Asn Glu His Lys Arg Pro Ser 
1               5           


<210>  176
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_72 LCDR3

<400>  176

Ser Ser Arg Asp Thr Gly Gly Lys His Val Leu 
1               5                   10      


<210>  177
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_75 HCDR1

<400>  177

Ser Tyr Thr Leu Asp 
1               5   


<210>  178
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_75 HCDR2

<400>  178

Gly Ile Ile Pro Val Phe Gly Ser Pro Asn Tyr Gly Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  179
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_75 HCDR3

<400>  179

Gly Leu Val Tyr Gln Pro Leu Asp Ser 
1               5                   


<210>  180
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_75 LCDR1

<400>  180

Ser Gly Ser Ser Ser Asn Ile Gly Ser Tyr Thr Val Asn 
1               5                   10              


<210>  181
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_75 LCDR2

<400>  181

Ser Asn Thr Gln Arg Pro Ser 
1               5           


<210>  182
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_75 LCDR3

<400>  182

Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 
1               5                   10      


<210>  183
<211>  61
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Tn3_pETFwd2

<400>  183
cgatcatatg gactacaagg acgacgatga caagggcagc cgtctggatg caccgagcca       60

g                                                                       61


<210>  184
<211>  43
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Tn3_pETRev2

<400>  184
atcgggatcc ctacagaccg gttttaaagg taatttttgc cgg                         43


<210>  185
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  185

Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10      


<210>  186
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_57 VH

<400>  186

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Thr Asn Tyr Ile Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  187
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_57 VL

<400>  187

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp His His Trp 
                85                  90                  95      


Glu Gln Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  188
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_01 VH

<400>  188

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gln Gly Tyr Ile Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  189
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_01 VL

<400>  189

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp His His Trp 
                85                  90                  95      


Glu Gln Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  190
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_04 VH

<400>  190

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Met Ala His Phe Tyr Gln Phe Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  191
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_04 VL

<400>  191

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Gly Asp His Asp His 
                85                  90                  95      


Glu His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  192
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_67 VH

<400>  192

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ala Val Arg Ile Ser Cys Lys Thr Ser Gly Tyr Val Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Asn Pro Ser Gly Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Thr Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Met Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Asp Tyr Gly Gly Pro Leu Ala Asn Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  193
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_67 VL

<400>  193

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Phe Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Leu Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  194
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_72 VH

<400>  194

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Met Ala His Phe Tyr Gln Phe Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  195
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_72 VL

<400>  195

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Gly Asp His Asp His 
                85                  90                  95      


Glu His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  196
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_75 VH

<400>  196

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Asn Ser Tyr 
            20                  25                  30          


Thr Leu Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Val Phe Gly Ser Pro Asn Tyr Gly Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Val Tyr Gln Pro Leu Asp Ser Trp Gly Arg Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  197
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_75 VL

<400>  197

Gln Ala Val Leu Thr Gln Pro Ser Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Tyr 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Phe Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Thr Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  198
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PRSIM_01 HCDR3

<400>  198

Gly Gln Gly Tyr Ile Thr Val Phe Asp Tyr 
1               5                   10  


<210>  199
<211>  631
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Full length NS3 protein

<400>  199

Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys 
1               5                   10                  15      


Gln Glu Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu 
            20                  25                  30          


Val Gln Ile Val Ser Thr Ala Ala Gln Thr Phe Leu Ala Thr Ser Ile 
        35                  40                  45              


Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile 
    50                  55                  60                  


Ala Ser Pro Lys Gly Pro Val Ile Gln Met Tyr Thr Asn Val Asp Gln 
65                  70                  75                  80  


Asp Leu Val Gly Trp Pro Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro 
                85                  90                  95      


Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp 
            100                 105                 110         


Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser 
        115                 120                 125             


Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu 
    130                 135                 140                 


Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Cys Thr 
145                 150                 155                 160 


Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Asn Leu Glu 
                165                 170                 175     


Thr Thr Met Arg Ser Pro Val Phe Thr Asp Asn Ser Ser Pro Pro Val 
            180                 185                 190         


Val Pro Gln Ser Phe Gln Val Ala His Leu His Ala Pro Thr Gly Ser 
        195                 200                 205             


Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys 
    210                 215                 220                 


Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala 
225                 230                 235                 240 


Tyr Met Ser Lys Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly Val 
                245                 250                 255     


Arg Thr Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly Lys 
            260                 265                 270         


Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile Ile 
        275                 280                 285             


Cys Asp Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile Gly 
    290                 295                 300                 


Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Val Val Leu 
305                 310                 315                 320 


Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn Ile 
                325                 330                 335     


Glu Glu Val Ala Leu Ser Thr Thr Gly Glu Ile Pro Phe Tyr Gly Lys 
            340                 345                 350         


Ala Ile Pro Leu Glu Val Ile Lys Gly Gly Arg His Leu Ile Phe Cys 
        355                 360                 365             


His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val Ala Leu 
    370                 375                 380                 


Gly Ile Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile 
385                 390                 395                 400 


Pro Thr Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met Thr 
                405                 410                 415     


Gly Tyr Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys Val 
            420                 425                 430         


Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu Thr 
        435                 440                 445             


Ile Thr Leu Pro Gln Asp Ala Val Ser Arg Thr Gln Arg Arg Gly Arg 
    450                 455                 460                 


Thr Gly Arg Gly Lys Pro Gly Ile Tyr Arg Phe Val Ala Pro Gly Glu 
465                 470                 475                 480 


Arg Pro Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr Asp 
                485                 490                 495     


Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val Arg 
            500                 505                 510         


Leu Arg Ala Tyr Met Asn Thr Pro Gly Leu Pro Val Cys Gln Asp His 
        515                 520                 525             


Leu Glu Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp Ala 
    530                 535                 540                 


His Phe Leu Ser Gln Thr Lys Gln Ser Gly Glu Asn Leu Pro Tyr Leu 
545                 550                 555                 560 


Val Ala Tyr Gln Ala Thr Val Cys Ala Arg Ala Gln Ala Pro Pro Pro 
                565                 570                 575     


Ser Trp Asp Gln Met Trp Lys Cys Leu Ile Arg Leu Lys Pro Thr Leu 
            580                 585                 590         


His Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn Glu 
        595                 600                 605             


Ile Thr Leu Thr His Pro Val Thr Lys Tyr Ile Met Thr Cys Met Ser 
    610                 615                 620                 


Ala Asp Leu Glu Val Val Thr 
625                 630     


<210>  200
<211>  319
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_23 CAR 2nd  polypeptide

<400>  200

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Phe Trp Val Leu 
1               5                   10                  15      


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
            20                  25                  30          


Ala Phe Ile Ile Phe Trp Val Ser Leu Lys Arg Gly Arg Lys Lys Leu 
        35                  40                  45              


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    50                  55                  60                  


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
65                  70                  75                  80  


Cys Glu Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Gly Ser 
                85                  90                  95      


Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr 
            100                 105                 110         


Thr Ala Leu Ile Thr Trp Val Asp Pro Arg Tyr Asp Asp Ile Trp Trp 
        115                 120                 125             


Phe Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr 
    130                 135                 140                 


Ile Lys Leu Tyr Leu Asn Asp Pro Tyr Tyr Ser Ile Gly Asn Leu Lys 
145                 150                 155                 160 


Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Tyr Thr Gly Asp Ser 
                165                 170                 175     


Tyr Ser Arg Ser Gly Ser Asn Pro Ala Lys Ile Thr Phe Lys Thr Gly 
            180                 185                 190         


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Arg Val Lys Phe 
        195                 200                 205             


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
    210                 215                 220                 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
225                 230                 235                 240 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
                245                 250                 255     


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
            260                 265                 270         


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
        275                 280                 285             


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
    290                 295                 300                 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly 
305                 310                 315                 


<210>  201
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_23 CAR 1st  signal peptide

<400>  201

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  202
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_23 CAR 2nd signal peptide

<400>  202

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


<210>  203
<211>  367
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_23 CAR 2nd  polypeptide + signal peptide

<400>  203

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Phe Trp Val Leu 
    50                  55                  60                  


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
65                  70                  75                  80  


Ala Phe Ile Ile Phe Trp Val Ser Leu Lys Arg Gly Arg Lys Lys Leu 
                85                  90                  95      


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
            100                 105                 110         


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
        115                 120                 125             


Cys Glu Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Gly Ser 
    130                 135                 140                 


Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr 
145                 150                 155                 160 


Thr Ala Leu Ile Thr Trp Val Asp Pro Arg Tyr Asp Asp Ile Trp Trp 
                165                 170                 175     


Phe Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr 
            180                 185                 190         


Ile Lys Leu Tyr Leu Asn Asp Pro Tyr Tyr Ser Ile Gly Asn Leu Lys 
        195                 200                 205             


Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Tyr Thr Gly Asp Ser 
    210                 215                 220                 


Tyr Ser Arg Ser Gly Ser Asn Pro Ala Lys Ile Thr Phe Lys Thr Gly 
225                 230                 235                 240 


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Arg Val Lys Phe 
                245                 250                 255     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
            260                 265                 270         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        275                 280                 285             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    290                 295                 300                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
305                 310                 315                 320 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                325                 330                 335     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            340                 345                 350         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly 
        355                 360                 365         


<210>  204
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Linker

<400>  204

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  205
<211>  458
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MEDI8852 heavy chain

<400>  205

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Tyr 
            20                  25                  30          


Asn Ala Val Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Gly Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Glu Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Ser Gly His Ile Thr Val Phe Gly Val Asn Val 
            100                 105                 110         


Asp Ala Phe Asp Met Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
    130                 135                 140                 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
145                 150                 155                 160 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
                165                 170                 175     


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
            180                 185                 190         


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
        195                 200                 205             


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
    210                 215                 220                 


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
        275                 280                 285             


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    290                 295                 300                 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                325                 330                 335     


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            340                 345                 350         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        355                 360                 365             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    370                 375                 380                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
385                 390                 395                 400 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            420                 425                 430         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        435                 440                 445             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455             


<210>  206
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MEDI8852 light chain

<400>  206

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Ser Leu Ser Ser Tyr 
            20                  25                  30          


Thr His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Arg Gly Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Thr Phe Gly Gln 
                85                  90                  95      


Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
            100                 105                 110         


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
        115                 120                 125             


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
    130                 135                 140                 


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
145                 150                 155                 160 


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
                165                 170                 175     


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
            180                 185                 190         


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
        195                 200                 205             


Glu Cys 
    210 


<210>  207
<211>  849
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DBD-PRSIM_23x3-P2A-NS4A/3 PR S139A-AD

<400>  207

Met Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Arg Glu Arg 
1               5                   10                  15      


Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser 
            20                  25                  30          


Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe 
        35                  40                  45              


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr 
    50                  55                  60                  


Thr His Ile Arg Thr His Thr Gly Gly Gly Arg Arg Arg Lys Lys Arg 
65                  70                  75                  80  


Thr Ser Ile Glu Thr Asn Ile Arg Val Ala Leu Glu Lys Ser Phe Leu 
                85                  90                  95      


Glu Asn Gln Lys Pro Thr Ser Glu Glu Ile Thr Met Ile Ala Asp Gln 
            100                 105                 110         


Leu Asn Met Glu Lys Glu Val Ile Arg Val Trp Phe Cys Asn Arg Arg 
        115                 120                 125             


Gln Lys Glu Lys Arg Ile Asn Thr Ser Ala Gly Ser Arg Leu Asp Ala 
    130                 135                 140                 


Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala Leu Ile 
145                 150                 155                 160 


Thr Trp Val Asp Pro Arg Tyr Asp Asp Ile Trp Trp Phe Glu Leu Thr 
                165                 170                 175     


Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr Ile Lys Leu Tyr 
            180                 185                 190         


Leu Asn Asp Pro Tyr Tyr Ser Ile Gly Asn Leu Lys Pro Asp Thr Glu 
        195                 200                 205             


Tyr Glu Val Ser Leu Ile Ser Tyr Thr Gly Asp Ser Tyr Ser Arg Ser 
    210                 215                 220                 


Gly Ser Asn Pro Ala Lys Ile Thr Phe Lys Thr Gly Leu Arg Leu Asp 
225                 230                 235                 240 


Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala Leu 
                245                 250                 255     


Ile Thr Trp Val Asp Pro Arg Tyr Asp Asp Ile Trp Trp Phe Glu Leu 
            260                 265                 270         


Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr Ile Lys Leu 
        275                 280                 285             


Tyr Leu Asn Asp Pro Tyr Tyr Ser Ile Gly Asn Leu Lys Pro Asp Thr 
    290                 295                 300                 


Glu Tyr Glu Val Ser Leu Ile Ser Tyr Thr Gly Asp Ser Tyr Ser Arg 
305                 310                 315                 320 


Ser Gly Ser Asn Pro Ala Lys Ile Thr Phe Lys Thr Gly Leu Arg Leu 
                325                 330                 335     


Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val Thr Asp Thr Thr Ala 
            340                 345                 350         


Leu Ile Thr Trp Val Asp Pro Arg Tyr Asp Asp Ile Trp Trp Phe Glu 
        355                 360                 365             


Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp Arg Thr Thr Ile Lys 
    370                 375                 380                 


Leu Tyr Leu Asn Asp Pro Tyr Tyr Ser Ile Gly Asn Leu Lys Pro Asp 
385                 390                 395                 400 


Thr Glu Tyr Glu Val Ser Leu Ile Ser Tyr Thr Gly Asp Ser Tyr Ser 
                405                 410                 415     


Arg Ser Gly Ser Asn Pro Ala Lys Ile Thr Phe Lys Thr Gly Leu Thr 
            420                 425                 430         


Ser Lys Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
        435                 440                 445             


Asp Val Glu Glu Asn Pro Gly Pro Met Ala Lys Lys Gly Ser Val Val 
    450                 455                 460                 


Ile Val Gly Arg Ile Asn Leu Ser Gly Asp Thr Ala Tyr Ala Gln Gln 
465                 470                 475                 480 


Thr Arg Gly Glu Glu Gly Cys Gln Glu Thr Ser Gln Thr Gly Arg Asp 
                485                 490                 495     


Lys Asn Gln Val Glu Gly Glu Val Gln Ile Val Ser Thr Ala Thr Gln 
            500                 505                 510         


Thr Phe Leu Ala Thr Ser Ile Asn Gly Val Leu Trp Thr Val Tyr His 
        515                 520                 525             


Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Thr Gln 
    530                 535                 540                 


Met Tyr Thr Asn Val Asp Lys Asp Leu Val Gly Trp Gln Ala Pro Gln 
545                 550                 555                 560 


Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr 
                565                 570                 575     


Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly Asp 
            580                 585                 590         


Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly 
        595                 600                 605             


Ser Ala Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly Ile 
    610                 615                 620                 


Phe Arg Ala Ala Val Ser Thr Arg Gly Val Ala Lys Ala Val Asp Phe 
625                 630                 635                 640 


Ile Pro Val Glu Ser Leu Glu Thr Thr Met Arg Ser Pro Thr Arg Asp 
                645                 650                 655     


Glu Phe Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser 
            660                 665                 670         


Ala Leu Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro 
        675                 680                 685             


Ala Pro Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro 
    690                 695                 700                 


Val Pro Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala 
705                 710                 715                 720 


Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu 
                725                 730                 735     


Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser 
            740                 745                 750         


Thr Asp Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu 
        755                 760                 765             


Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr 
    770                 775                 780                 


Glu Pro Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr 
785                 790                 795                 800 


Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro 
                805                 810                 815     


Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile 
            820                 825                 830         


Ala Asp Met Asp Phe Ser Ala Leu Leu Ser Gln Ile Ser Ser Thr Ser 
        835                 840                 845             


Tyr 
    


<210>  208
<211>  2547
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DBD-PRSIM_23x3-P2A-NS4A/3 PR S139A-AD

<400>  208
atggactatc ctgctgccaa gagggtcaag ttggactcta gagaacgccc atatgcttgc       60

cctgtcgagt cctgcgatcg ccgcttttct cgctcggatg agcttacccg ccatatccgc      120

atccacacag gccagaagcc cttccagtgt cgaatctgca tgcgtaactt cagtcgtagt      180

gaccacctta ccacccacat ccgcacccac acaggcggcg gccgcaggag gaagaaacgc      240

accagcatag agaccaacat ccgtgtggcc ttagagaaga gtttcttgga gaatcaaaag      300

cctacctcgg aagagatcac tatgattgct gatcagctca atatggaaaa agaggtgatt      360

cgtgtttggt tctgtaaccg ccgccagaaa gaaaaaagaa tcaacactag cgctggctct      420

agactggatg cccctagcca gatcgaagtg aaggacgtga ccgacaccac cgctctgatc      480

acctgggttg accccagata cgacgacatc tggtggttcg agctgaccta cggcatcaag      540

gatgtgcccg gcgacagaac caccatcaag ctgtacctga acgaccccta ctacagcatc      600

ggcaacctga agcctgacac cgagtacgag gtgtccctga tcagctacac cggcgactcc      660

tacagcagaa gcggcagcaa tcctgccaag atcaccttca agaccggcct gagactggac      720

gcaccctctc agattgaagt caaagatgtc accgacacga cagccctgat tacatgggtt      780

gaccctcgct acgatgatat ttggtggttt gaactcacgt acgggatcaa agacgtgcca      840

ggggatcgca caacaatcaa gctctatctc aatgatccgt actactccat cgggaatctg      900

aaacccgata cagagtacga agtctccctc atctcttaca ccggggacag ctactccaga      960

tccggctcca atccagccaa aattacgttt aagacaggcc tgcggctgga tgctccatct     1020

caaatagaag ttaaggatgt gacggatacg acggccctca tcacttgggt tgaccctcga     1080

tatgacgata tttggtggtt cgaattgacg tatggcatta aggacgtccc aggcgaccgg     1140

acaactatta agctgtatct taacgatcct tattatagca tcggaaatct caagccggat     1200

accgaatatg aggtttccct catttcctat actggggact cctactctcg ctccggctct     1260

aacccagcta agatcacttt taaaaccggg cttacttcga aaggaagcgg cgccacaaac     1320

tttagcctgc tgaaacaggc cggcgacgtc gaagaaaatc ccgggcctat ggctaaaaag     1380

ggctctgtgg tcatcgtggg cagaatcaac ctgagcggcg ataccgccta cgctcagcag     1440

acaagaggcg aggaaggctg ccaagagaca agccagaccg gcagagacaa gaaccaggtg     1500

gaaggcgagg tgcagatcgt gtctacagct acccagacct tcctggccac cagcatcaat     1560

ggcgtgctgt ggacagtgta tcacggcgct ggcaccagaa caatcgcctc tccaaagggc     1620

cccgtgacac agatgtatac caacgtggac aaggacctcg tcggatggca agcccctcag     1680

ggctctagaa gcctgacacc ttgtacctgc ggcagcagcg atctgtacct ggtcacaaga     1740

cacgccgacg tgatccccgt cagaagaaga ggcgatagca gaggcagcct gctgagccct     1800

agacctatca gctacctgaa gggatctgcc ggcggacctc tgctttgtcc tgctggacat     1860

gccgtgggca tctttagagc cgccgtgtct actagaggcg tggccaaggc cgtggacttc     1920

atccctgtgg aaagcctgga aaccaccatg cggagcccca ctagagatga gtttcccacc     1980

atggtgtttc cttctgggca gatcagccag gcctcggcct tggccccggc ccctccccaa     2040

gtcctgcccc aggctccagc ccctgcccct gctccagcca tggtatcagc tctggcccag     2100

gccccagccc ctgtcccagt cctagcccca ggccctcctc aggctgtggc cccacctgcc     2160

cccaagccca cccaggctgg ggaaggaacg ctgtcagagg ccctgctgca gctgcagttt     2220

gatgatgaag acctgggggc cttgcttggc aacagcacag acccagctgt gttcacagac     2280

ctggcatccg tcgacaactc cgagtttcag cagctgctga accagggcat acctgtggcc     2340

ccccacacaa ctgagcccat gctgatggag taccctgagg ctataactcg cctagtgaca     2400

ggggcccaga ggccccccga cccagctcct gctccactgg gggccccggg gctccccaat     2460

ggcctccttt caggagatga agacttctcc tccattgcgg acatggactt ctcagccctg     2520

ctgagtcaga tcagctccac tagttat                                         2547


<210>  209
<211>  153
<212>  PRT
<213>  Artificial sequence

<220>
<223>  huIL-2

<400>  209

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  210
<211>  459
<212>  DNA
<213>  Artificial sequence

<220>
<223>  huIL-2

<400>  210
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcccctacca gcagcagcac caagaaaacc cagctgcaac tggaacacct cctgctggac      120

ctgcagatga tcctgaacgg catcaacaac tacaagaacc ccaagctgac ccggatgctg      180

accttcaagt tctacatgcc caagaaggcc accgagctga agcacctcca gtgcctggaa      240

gaggaactga agcccctgga agaagtgctg aatctggccc agagcaagaa cttccacctg      300

aggcctaggg acctgatcag caacatcaac gtgatcgtgc tggaactgaa aggcagcgag      360

acaaccttca tgtgcgagta cgccgacgag acagctacca tcgtggaatt tctgaaccgg      420

tggatcacct tctgccagag catcatcagc accctgacc                             459


<210>  211
<211>  199
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NS4A/3 PR S139A K136D

<400>  211

Met Gly Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu 
1               5                   10                  15      


Ser Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys 
            20                  25                  30          


Gln Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu 
        35                  40                  45              


Val Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile 
    50                  55                  60                  


Asn Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile 
65                  70                  75                  80  


Ala Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys 
                85                  90                  95      


Asp Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro 
            100                 105                 110         


Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp 
        115                 120                 125             


Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser 
    130                 135                 140                 


Pro Arg Pro Ile Ser Tyr Leu Asp Gly Ser Ala Gly Gly Pro Leu Leu 
145                 150                 155                 160 


Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr 
                165                 170                 175     


Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu 
            180                 185                 190         


Thr Thr Met Arg Ser Pro Thr 
        195                 


<210>  212
<211>  597
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NS4A/3 PR S139A K136D

<400>  212
atgggcaaga aaaagggcag cgtggtcatc gtgggcagaa tcaacctgag cggcgatacc       60

gcctacgctc agcagacaag aggcgaggaa ggctgccaag agacaagcca gaccggcaga      120

gacaagaacc aggtggaagg cgaggtgcag atcgtgtcta cagctaccca gaccttcctg      180

gccaccagca tcaatggcgt gctgtggaca gtgtatcacg gcgctggcac cagaacaatc      240

gcctctccaa agggccccgt gacacagatg tacaccaacg tggacaagga cctcgtcgga      300

tggcaagccc ctcagggaag cagaagcctg acaccttgta cctgcggcag cagcgatctg      360

tacctggtca caagacacgc cgacgtgatc cccgtcagaa gaagaggcga tagcagaggc      420

agcctgctga gccctagacc tatcagctac ctggatggat ctgccggcgg acctctgctt      480

tgtcctgctg gacatgccgt gggcatcttt agagccgccg tgtctactag aggcgtggcc      540

aaagccgtgg acttcatccc cgtggaaagc ctggaaacca ccatgagatc tccaacc         597


<210>  213
<211>  199
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NS4A/3 PR S139A D168E

<400>  213

Met Gly Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu 
1               5                   10                  15      


Ser Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys 
            20                  25                  30          


Gln Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu 
        35                  40                  45              


Val Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile 
    50                  55                  60                  


Asn Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile 
65                  70                  75                  80  


Ala Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys 
                85                  90                  95      


Asp Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro 
            100                 105                 110         


Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp 
        115                 120                 125             


Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser 
    130                 135                 140                 


Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu 
145                 150                 155                 160 


Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr 
                165                 170                 175     


Arg Gly Val Ala Lys Ala Val Glu Phe Ile Pro Val Glu Ser Leu Glu 
            180                 185                 190         


Thr Thr Met Arg Ser Pro Thr 
        195                 


<210>  214
<211>  597
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NS4A/3 PR S139A D168E

<400>  214
atgggcaaga aaaagggcag cgtggtcatc gtgggcagaa tcaacctgag cggcgatacc       60

gcctacgctc agcagacaag aggcgaggaa ggctgccaag agacaagcca gaccggcaga      120

gacaagaacc aggtggaagg cgaggtgcag atcgtgtcta cagctaccca gaccttcctg      180

gccaccagca tcaatggcgt gctgtggaca gtgtatcacg gcgctggcac cagaacaatc      240

gcctctccaa agggccccgt gacacagatg tacaccaacg tggacaagga cctcgtcgga      300

tggcaagccc ctcagggaag cagaagcctg acaccttgta cctgcggcag cagcgatctg      360

tacctggtca caagacacgc cgacgtgatc cccgtcagaa gaagaggcga tagcagaggc      420

agcctgctga gccctagacc tatcagctac ctgaagggat ctgccggcgg acctctgctt      480

tgtcctgctg gacatgccgt gggcatcttt agagccgccg tgtctactag aggcgtggcc      540

aaagccgtgg aattcatccc cgtggaaagc ctggaaacca ccatgagatc tccaacc         597


<210>  215
<211>  199
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NS4A/3 PR S139A K136N

<400>  215

Met Gly Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu 
1               5                   10                  15      


Ser Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys 
            20                  25                  30          


Gln Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu 
        35                  40                  45              


Val Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile 
    50                  55                  60                  


Asn Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile 
65                  70                  75                  80  


Ala Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys 
                85                  90                  95      


Asp Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro 
            100                 105                 110         


Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp 
        115                 120                 125             


Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser 
    130                 135                 140                 


Pro Arg Pro Ile Ser Tyr Leu Asn Gly Ser Ala Gly Gly Pro Leu Leu 
145                 150                 155                 160 


Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr 
                165                 170                 175     


Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu 
            180                 185                 190         


Thr Thr Met Arg Ser Pro Thr 
        195                 


<210>  216
<211>  597
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NS4A/3 PR S139A K136N

<400>  216
atgggcaaga aaaagggcag cgtggtcatc gtgggcagaa tcaacctgag cggcgatacc       60

gcctacgctc agcagacaag aggcgaggaa ggctgccaag agacaagcca gaccggcaga      120

gacaagaacc aggtggaagg cgaggtgcag atcgtgtcta cagctaccca gaccttcctg      180

gccaccagca tcaatggcgt gctgtggaca gtgtatcacg gcgctggcac cagaacaatc      240

gcctctccaa agggccccgt gacacagatg tacaccaacg tggacaagga cctcgtcgga      300

tggcaggctc ctcagggctc tagaagcctg acaccttgta cctgcggcag cagcgatctg      360

tacctggtca caagacacgc cgacgtgatc cccgtcagaa gaagaggcga tagcagaggc      420

agcctgctga gccctagacc tatcagctac ctgaacggat ctgccggcgg acctctgctt      480

tgtcctgctg gacatgccgt gggcatcttt agagccgccg tgtctactag aggcgtggcc      540

aaagccgtgg acttcatccc tgtggaaagc ctggaaacca ccatgagaag ccccacc         597


<210>  217
<211>  215
<212>  PRT
<213>  Artificial sequence

<220>
<223>  His-TEV-NS4A/3 PR S139A

<400>  217

Met Gly Ser Ser His His His His His His Gly Ser Glu Asn Leu Tyr 
1               5                   10                  15      


Phe Gln Ser Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn 
            20                  25                  30          


Leu Ser Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly 
        35                  40                  45              


Cys Gln Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly 
    50                  55                  60                  


Glu Val Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser 
65                  70                  75                  80  


Ile Asn Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr 
                85                  90                  95      


Ile Ala Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp 
            100                 105                 110         


Lys Asp Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr 
        115                 120                 125             


Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala 
    130                 135                 140                 


Asp Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu 
145                 150                 155                 160 


Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu 
                165                 170                 175     


Leu Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser 
            180                 185                 190         


Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu 
        195                 200                 205             


Glu Thr Thr Met Arg Ser Pro 
    210                 215 


<210>  218
<211>  645
<212>  DNA
<213>  Artificial sequence

<220>
<223>  His-TEV-NS4A/3 PR S139A

<400>  218
atgggtagca gccatcacca tcatcatcat ggtagcgaaa atctgtattt ccagagcaaa       60

aaaaagggca gcgttgttat tgtgggtcgt attaatctga gcggtgatac cgcatatgca      120

cagcagaccc gtggtgaaga aggttgtcaa gaaaccagcc agaccggtcg tgataaaaat      180

caggttgaag gtgaagttca gattgttagc accgcaacac agacctttct ggcaaccagc      240

attaatggtg ttctgtggac cgtttatcat ggtgcaggca cccgtaccat tgcaagcccg      300

aaaggtccgg ttacacagat gtataccaat gtggataaag atctggttgg ttggcaggca      360

ccgcagggta gccgtagtct gaccccgtgt acctgtggta gcagcgatct gtatctggtt      420

acccgtcatg cagatgttat tccggttcgt cgtcgtggtg atagccgtgg tagcctgctg      480

agtccgcgtc cgattagcta tctgaaaggt agtgccggtg gtccgctgct gtgtccggca      540

ggtcatgcag ttggtatttt tcgtgcagca gttagcaccc gtggcgttgc aaaagcagtt      600

gattttatcc cggttgaaag cctggaaacc accatgcgta gcccg                      645


<210>  219
<211>  197
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NS4A/3 S139A post-TEV cleavage

<400>  219

Ser Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu Ser 
1               5                   10                  15      


Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys Gln 
            20                  25                  30          


Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu Val 
        35                  40                  45              


Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile Asn 
    50                  55                  60                  


Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile Ala 
65                  70                  75                  80  


Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys Asp 
                85                  90                  95      


Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys 
            100                 105                 110         


Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val 
        115                 120                 125             


Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro 
    130                 135                 140                 


Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu Cys 
145                 150                 155                 160 


Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr Arg 
                165                 170                 175     


Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr 
            180                 185                 190         


Thr Met Arg Ser Pro 
        195         


<210>  220
<211>  280
<212>  PRT
<213>  Artificial sequence

<220>
<223>  pelB-PRSIM_57-TEV-His

<400>  220

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala 
65                  70                  75                  80  


Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
                85                  90                  95      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg His Thr Asn Tyr Ile Thr Val Phe 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gln Ser Val 
145                 150                 155                 160 


Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr 
                165                 170                 175     


Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
            180                 185                 190         


Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser 
        195                 200                 205             


Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
    210                 215                 220                 


Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp 
225                 230                 235                 240 


Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp His His Trp Glu Gln Val 
                245                 250                 255     


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Glu Asn Leu Tyr Phe 
            260                 265                 270         


Gln Ser His His His His His His 
        275                 280 


<210>  221
<211>  840
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pelB_PRSIM_57-TEV-His

<400>  221
atgaaatatc tgctgccgac cgcagcagcg ggtctgctgc tgctggcagc acagcctgca       60

atggcacagg ttcagctggt tcagagcggt gcagaagtta aaaaaccggg tagcagcgtt      120

aaagttagct gtaaagcaag cggtggcacc tttagcagct atgcaattag ctgggttcgt      180

caggcacctg gtcaaggtct ggaatggatg ggtggtatta ttccgatttt tggcaccgca      240

aattatgccc agaaatttca gggtcgtgtt accattaccg cagatgaaag caccagcacc      300

gcatatatgg aactgagcag cctgcgtagc gaagataccg cagtgtatta ttgtgcacgt      360

cataccaact atatcaccgt gtttgattat tggggtcagg gcaccctggt taccgttagc      420

agcggtggtg gtggtagcgg tggcggaggt tcaggtggtg gcggttcagc acagagcgtt      480

ctgacccagc ctccgagcgc aagcggtaca ccgggtcagc gtgtgaccat tagctgtagc      540

ggtagcagca gtaatattgg tagcaatacc gttaattggt atcagcagct gccaggcacc      600

gcaccgaaac tgctgattta tagcaataat cagcgtccga gcggtgttcc ggatcgtttt      660

agcggtagta aaagcggcac cagcgcaagc ctggcaatta gcggtctgca gagcgaagat      720

gaagcagatt attactgtgc agcatgggat catcattggg aacaagttgt ttttggtggt      780

ggcaccaaac tgaccgttct ggaaaatctg tatttccaga gccatcacca tcatcatcat      840


<210>  222
<211>  251
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM_57 post-TEV cleavage, pelB removal

<400>  222

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Thr Asn Tyr Ile Thr Val Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Ala Gln Ser Val Leu Thr Gln Pro Pro Ser 
    130                 135                 140                 


Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser 
145                 150                 155                 160 


Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro 
                165                 170                 175     


Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser 
            180                 185                 190         


Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
        195                 200                 205             


Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Ala Ala Trp Asp His His Trp Glu Gln Val Val Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Thr Val Leu Glu Asn Leu Tyr Phe Gln 
                245                 250     


<210>  223
<211>  591
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM23_NS4A/3 PR S139A_DCasp9

<400>  223

Met Gly Ser Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val 
1               5                   10                  15      


Thr Asp Thr Thr Ala Leu Ile Thr Trp Val Asp Pro Arg Tyr Asp Asp 
            20                  25                  30          


Ile Trp Trp Phe Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp 
        35                  40                  45              


Arg Thr Thr Ile Lys Leu Tyr Leu Asn Asp Pro Tyr Tyr Ser Ile Gly 
    50                  55                  60                  


Asn Leu Lys Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Tyr Thr 
65                  70                  75                  80  


Gly Asp Ser Tyr Ser Arg Ser Gly Ser Asn Pro Ala Lys Ile Thr Phe 
                85                  90                  95      


Lys Thr Gly Leu Gly Gly Gly Ser Gly Met Lys Lys Lys Gly Ser Val 
            100                 105                 110         


Val Ile Val Gly Arg Ile Asn Leu Ser Gly Asp Thr Ala Tyr Ala Gln 
        115                 120                 125             


Gln Thr Arg Gly Glu Glu Gly Cys Gln Glu Thr Ser Gln Thr Gly Arg 
    130                 135                 140                 


Asp Lys Asn Gln Val Glu Gly Glu Val Gln Ile Val Ser Thr Ala Thr 
145                 150                 155                 160 


Gln Thr Phe Leu Ala Thr Ser Ile Asn Gly Val Leu Trp Thr Val Tyr 
                165                 170                 175     


His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Thr 
            180                 185                 190         


Gln Met Tyr Thr Asn Val Asp Lys Asp Leu Val Gly Trp Gln Ala Pro 
        195                 200                 205             


Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu 
    210                 215                 220                 


Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly 
225                 230                 235                 240 


Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys 
                245                 250                 255     


Gly Ser Ala Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly 
            260                 265                 270         


Ile Phe Arg Ala Ala Val Ser Thr Arg Gly Val Ala Lys Ala Val Asp 
        275                 280                 285             


Phe Ile Pro Val Glu Ser Leu Glu Thr Thr Met Arg Ser Pro Gly Gly 
    290                 295                 300                 


Gly Ser Gly Val Asp Gly Phe Gly Asp Val Gly Ala Leu Glu Ser Leu 
305                 310                 315                 320 


Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys Gly 
                325                 330                 335     


His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly Leu 
            340                 345                 350         


Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg Arg 
        355                 360                 365             


Phe Ser Ser Leu His Phe Met Val Glu Val Lys Gly Asp Leu Thr Ala 
    370                 375                 380                 


Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala Arg Gln Asp His Gly 
385                 390                 395                 400 


Ala Leu Asp Cys Cys Val Val Val Ile Leu Ser His Gly Cys Gln Ala 
                405                 410                 415     


Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys Pro 
            420                 425                 430         


Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys Pro 
        435                 440                 445             


Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly Gly 
    450                 455                 460                 


Glu Gln Lys Asp His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu Asp 
465                 470                 475                 480 


Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu 
                485                 490                 495     


Gly Leu Arg Thr Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro Thr 
            500                 505                 510         


Pro Ser Asp Ile Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser 
        515                 520                 525             


Trp Arg Asp Pro Lys Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp 
    530                 535                 540                 


Ile Phe Glu Gln Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu 
545                 550                 555                 560 


Arg Val Ala Asn Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro 
                565                 570                 575     


Gly Cys Phe Asn Phe Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
            580                 585                 590     


<210>  224
<211>  1779
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM23_NS4A/3 PR S139A_DCasp9

<400>  224
atgggctcta gactggatgc ccctagccag atcgaagtga aggacgtgac cgacaccacc       60

gctctgatca cctgggttga ccccagatac gacgatatct ggtggttcga gctgacctac      120

ggcatcaagg atgtgcccgg cgacagaacc accatcaagc tgtacctgaa cgacccctac      180

tacagcatcg gcaacctgaa gcctgacacc gagtacgagg tgtccctgat cagctacacc      240

ggcgactcct acagcagaag cggcagcaat cctgccaaga tcaccttcaa gaccggcctt      300

gggggcggat ccggcatgaa gaaaaagggc tctgtggtca tcgtgggcag aatcaacctg      360

agcggcgata ccgcctacgc tcagcagaca agaggcgagg aaggctgcca agagacaagc      420

cagaccggca gagacaagaa ccaggtggaa ggcgaggtgc agatcgtgtc tacagctacc      480

cagaccttcc tggccaccag catcaatggc gtgctgtgga cagtgtatca cggcgctggc      540

accagaacaa tcgcctctcc aaagggcccc gtgacacaga tgtacaccaa cgtggacaag      600

gacctcgtcg gatggcaagc ccctcagggc tctagaagcc tgacaccttg tacctgcggc      660

agcagcgatc tgtacctggt cacaagacac gccgacgtga tccccgtcag aagaagaggc      720

gatagcagag gcagcctgct gagccctaga cctatcagct acctgaaggg atctgccggc      780

ggacctctgc tttgtcctgc tggacatgcc gtgggcatct ttagagccgc cgtgtctact      840

agaggcgtgg ccaaagccgt ggacttcatc cctgtggaaa gcctggaaac caccatgcgg      900

agccccgggg gaggctccgg cgtggatggc tttggagatg tgggcgccct ggaatccctg      960

agaggaaatg ccgatctggc ctacatcctg agcatggaac cttgcggcca ctgcctgatt     1020

atcaacaatg tgaacttctg ccgcgagagc ggcctgagaa caagaaccgg cagcaacatc     1080

gattgcgaga agctgcggag aagattcagc agcctgcact tcatggtgga agtgaagggc     1140

gacctgaccg ccaagaaaat ggtgctggct ctgctggaac tggccagaca ggatcatggc     1200

gcactggatt gctgcgtggt cgtgattctg agccacggct gtcaggccag ccatctgcaa     1260

ttccctggcg ccgtgtatgg caccgatggc tgtcctgtgt ccgtggaaaa gatcgtgaac     1320

atcttcaacg gcaccagctg tcctagcctc ggcggaaagc ccaagctgtt cttcatccaa     1380

gcctgtggcg gcgagcagaa ggatcacgga tttgaggtgg ccagcacaag ccccgaggat     1440

gagagccctg gaagcaaccc tgagcctgac gccacacctt tccaagaggg actgagaacc     1500

ttcgaccagc tggacgctat cagctccctg cctacaccta gcgacatctt cgtgtcctac     1560

agcacattcc ccggctttgt gtcttggcgg gaccccaagt ctggctcttg gtacgtggaa     1620

accctggatg acatcttcga gcagtgggcc catagcgagg acctgcaatc tctgctgctg     1680

agagtggcca atgccgtgtc cgtgaagggc atctacaagc agatgcccgg ctgcttcaac     1740

ttcctgcgga agaagctgtt tttcaagacc agctgatag                            1779


<210>  225
<211>  740
<212>  PRT
<213>  Artificial sequence

<220>
<223>  NS4A/3 PR S139A-VPR

<400>  225

Met Gly Lys Lys Lys Gly Ser Val Val Ile Val Gly Arg Ile Asn Leu 
1               5                   10                  15      


Ser Gly Asp Thr Ala Tyr Ala Gln Gln Thr Arg Gly Glu Glu Gly Cys 
            20                  25                  30          


Gln Glu Thr Ser Gln Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu 
        35                  40                  45              


Val Gln Ile Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr Ser Ile 
    50                  55                  60                  


Asn Gly Val Leu Trp Thr Val Tyr His Gly Ala Gly Thr Arg Thr Ile 
65                  70                  75                  80  


Ala Ser Pro Lys Gly Pro Val Thr Gln Met Tyr Thr Asn Val Asp Lys 
                85                  90                  95      


Asp Leu Val Gly Trp Gln Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro 
            100                 105                 110         


Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp 
        115                 120                 125             


Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser 
    130                 135                 140                 


Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ala Gly Gly Pro Leu Leu 
145                 150                 155                 160 


Cys Pro Ala Gly His Ala Val Gly Ile Phe Arg Ala Ala Val Ser Thr 
                165                 170                 175     


Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu 
            180                 185                 190         


Thr Thr Met Arg Ser Pro Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        195                 200                 205             


Ser Glu Ala Ser Gly Ser Gly Arg Ala Asp Ala Leu Asp Asp Phe Asp 
    210                 215                 220                 


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
225                 230                 235                 240 


Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
                245                 250                 255     


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Ile Asn Ser Arg Ser 
            260                 265                 270         


Ser Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Ser Gln Tyr Leu Pro 
        275                 280                 285             


Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys Arg Thr Tyr 
    290                 295                 300                 


Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe Ser Gly Pro Thr 
305                 310                 315                 320 


Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro Ser Arg Ser Ser 
                325                 330                 335     


Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro Phe Thr Ser Ser 
            340                 345                 350         


Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met Val Phe Pro Ser 
        355                 360                 365             


Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro Pro Gln Val 
    370                 375                 380                 


Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala Met Val Ser Ala 
385                 390                 395                 400 


Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala Pro Gly Pro Pro 
                405                 410                 415     


Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala Gly Glu Gly 
            420                 425                 430         


Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu Asp Leu 
        435                 440                 445             


Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val Phe Thr Asp Leu 
    450                 455                 460                 


Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Ile 
465                 470                 475                 480 


Pro Val Ala Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr Pro Glu 
                485                 490                 495     


Ala Ile Thr Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp Pro Ala 
            500                 505                 510         


Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser Gly 
        515                 520                 525             


Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu 
    530                 535                 540                 


Gly Ser Gly Ser Gly Ser Arg Asp Ser Arg Glu Gly Met Phe Leu Pro 
545                 550                 555                 560 


Lys Pro Glu Ala Gly Ser Ala Ile Ser Asp Val Phe Glu Gly Arg Glu 
                565                 570                 575     


Val Cys Gln Pro Lys Arg Ile Arg Pro Phe His Pro Pro Gly Ser Pro 
            580                 585                 590         


Trp Ala Asn Arg Pro Leu Pro Ala Ser Leu Ala Pro Thr Pro Thr Gly 
        595                 600                 605             


Pro Val His Glu Pro Val Gly Ser Leu Thr Pro Ala Pro Val Pro Gln 
    610                 615                 620                 


Pro Leu Asp Pro Ala Pro Ala Val Thr Pro Glu Ala Ser His Leu Leu 
625                 630                 635                 640 


Glu Asp Pro Asp Glu Glu Thr Ser Gln Ala Val Lys Ala Leu Arg Glu 
                645                 650                 655     


Met Ala Asp Thr Val Ile Pro Gln Lys Glu Glu Ala Ala Ile Cys Gly 
            660                 665                 670         


Gln Met Asp Leu Ser His Pro Pro Pro Arg Gly His Leu Asp Glu Leu 
        675                 680                 685             


Thr Thr Thr Leu Glu Ser Met Thr Glu Asp Leu Asn Leu Asp Ser Pro 
    690                 695                 700                 


Leu Thr Pro Glu Leu Asn Glu Ile Leu Asp Thr Phe Leu Asn Asp Glu 
705                 710                 715                 720 


Cys Leu Leu His Ala Met His Ile Ser Thr Gly Leu Ser Ile Phe Asp 
                725                 730                 735     


Thr Ser Leu Phe 
            740 


<210>  226
<211>  2220
<212>  DNA
<213>  Artificial sequence

<220>
<223>  NS4A/3 PR S139A-VPR

<400>  226
atgggcaaga aaaagggcag cgtggtcatc gtgggcagaa tcaacctgag cggcgatacc       60

gcctacgctc agcagacaag aggcgaggaa ggctgccaag agacaagcca gaccggcaga      120

gacaagaacc aggtggaagg cgaggtgcag atcgtgtcta cagctaccca gaccttcctg      180

gccaccagca tcaatggcgt gctgtggaca gtgtatcacg gcgctggcac cagaacaatc      240

gcctctccaa agggccccgt gacacagatg tacaccaacg tggacaagga cctcgtcgga      300

tggcaagccc ctcagggctc cagaagcctg acaccttgta cctgcggcag cagcgatctg      360

tacctggtca caagacacgc cgacgtgatc cccgtcagaa gaagaggcga tagcagaggc      420

agcctgctga gccctagacc tatcagctac ctgaagggat ctgccggcgg acctctgctt      480

tgtcctgctg gacatgccgt gggcatcttt agagccgccg tgtctactag aggcgtggcc      540

aaagccgtgg acttcatccc tgtggaaagc ctggaaacca ccatgagaag ccccaccggt      600

ggcggcggat ctggcggagg tggaagtgaa gcttctggca gcggtagagc cgacgctctg      660

gacgacttcg acctggatat gctgggctct gacgccctgg atgattttga tctggacatg      720

ctcggcagcg acgccctcga cgatttcgat ctcgatatgt tgggaagcga cgcacttgat      780

gactttgacc tcgacatgtt gatcaatagc agaagcagcg gcagccccaa gaaaaagcgg      840

aaagtgggca gccagtacct gcctgacacc gacgacagac accggatcga agagaagcgg      900

aagcggacct acgagacatt caagagcatc atgaagaagt ccccattcag cggccccacc      960

gatcctagac ctccacctag aagaatcgcc gtgcctagca gatctagcgc cagcgtgcca     1020

aaacctgctc ctcagcctta tcctttcacc agcagcctga gcaccatcaa ctacgacgag     1080

ttccctacca tggtgttccc cagcggccag atctctcagg cttctgctct tgctccagct     1140

cctcctcagg ttctgcctca agctcctgca ccagcaccgg ctccagctat ggtttctgct     1200

ttggctcagg cccctgctcc tgtgcctgtt cttgctcctg gaccacctca ggctgttgct     1260

cctcctgctc caaaacctac acaggccggc gagggaacac tgtctgaagc tctgctgcag     1320

ctccagttcg acgacgaaga tctgggagcc ctgctgggca atagcacaga tcctgccgtg     1380

ttcaccgatc tggccagcgt ggacaatagc gagttccagc agctcctgaa tcagggcatc     1440

cctgtggctc ctcacaccac cgaacctatg ctgatggaat accccgaggc catcaccaga     1500

ctggtcaccg gcgctcaaag accacctgat ccagctccag cacctctggg agcaccagga     1560

ctgcctaatg gactgctgtc tggcgacgag gacttcagct ctatcgccga catggatttc     1620

agcgccctgc tcggctctgg ctccggctct agagatagca gagaaggcat gttcctgcct     1680

aagcctgagg ccggctctgc catctccgat gtgtttgagg gcagagaagt gtgccagcct     1740

aagcggatcc ggccttttca ccctcctgga agcccttggg ccaacagacc tctgcctgct     1800

tctctggccc ctacaccaac aggacctgtg cacgaacctg tgggcagtct gaccccagct     1860

cctgttcctc aacctctgga tcccgctcct gctgtgacac ctgaagcctc tcatctgctg     1920

gaagatcccg acgaagagac aagccaggcc gtgaaggccc tgagagaaat ggccgacaca     1980

gtgatccctc agaaagagga agccgccatc tgcggacaga tggacctgtc tcatcctcca     2040

ccaagaggcc acctggacga gctgacaacc acactggaat ccatgaccga ggacctgaac     2100

ctggacagcc ctctgacacc cgagctgaac gagatcctgg acaccttcct gaacgacgag     2160

tgtctgctgc acgccatgca catctctacc ggcctgagca tcttcgacac cagcctgttc     2220


<210>  227
<211>  1682
<212>  PRT
<213>  Artificial sequence

<220>
<223>  spdCas9-PRSIM_23x3

<400>  227

Met Asp Tyr Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Asp Lys Lys Tyr 
1               5                   10                  15      


Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile 
            20                  25                  30          


Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn 
        35                  40                  45              


Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe 
    50                  55                  60                  


Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg 
65                  70                  75                  80  


Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile 
                85                  90                  95      


Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu 
            100                 105                 110         


Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro 
        115                 120                 125             


Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro 
    130                 135                 140                 


Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala 
145                 150                 155                 160 


Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg 
                165                 170                 175     


Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val 
            180                 185                 190         


Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu 
        195                 200                 205             


Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser 
    210                 215                 220                 


Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu 
225                 230                 235                 240 


Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser 
                245                 250                 255     


Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp 
            260                 265                 270         


Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn 
        275                 280                 285             


Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala 
    290                 295                 300                 


Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn 
305                 310                 315                 320 


Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr 
                325                 330                 335     


Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln 
            340                 345                 350         


Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn 
        355                 360                 365             


Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr 
    370                 375                 380                 


Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu 
385                 390                 395                 400 


Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe 
                405                 410                 415     


Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala 
            420                 425                 430         


Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg 
        435                 440                 445             


Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly 
    450                 455                 460                 


Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser 
465                 470                 475                 480 


Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly 
                485                 490                 495     


Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn 
            500                 505                 510         


Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr 
        515                 520                 525             


Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly 
    530                 535                 540                 


Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val 
545                 550                 555                 560 


Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys 
                565                 570                 575     


Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser 
            580                 585                 590         


Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu 
        595                 600                 605             


Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu 
    610                 615                 620                 


Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg 
625                 630                 635                 640 


Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp 
                645                 650                 655     


Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg 
            660                 665                 670         


Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys 
        675                 680                 685             


Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe 
    690                 695                 700                 


Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln 
705                 710                 715                 720 


Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala 
                725                 730                 735     


Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val 
            740                 745                 750         


Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu 
        755                 760                 765             


Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly 
    770                 775                 780                 


Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys 
785                 790                 795                 800 


Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln 
                805                 810                 815     


Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp 
            820                 825                 830         


Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp 
        835                 840                 845             


Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp 
    850                 855                 860                 


Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn 
865                 870                 875                 880 


Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln 
                885                 890                 895     


Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr 
            900                 905                 910         


Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile 
        915                 920                 925             


Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln 
    930                 935                 940                 


Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu 
945                 950                 955                 960 


Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp 
                965                 970                 975     


Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr 
            980                 985                 990         


His His Ala His Asp Ala Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu 
        995                 1000                 1005             


Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp 
    1010                 1015                 1020             


Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln 
    1025                 1030                 1035             


Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile 
    1040                 1045                 1050             


Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile 
    1055                 1060                 1065             


Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile 
    1070                 1075                 1080             


Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu 
    1085                 1090                 1095             


Ser Met  Pro Gln Val Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr 
    1100                 1105                 1110             


Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp 
    1115                 1120                 1125             


Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser Val Leu  Val Val Ala 
    1145                 1150                 1155             


Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu 
    1160                 1165                 1170             


Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn 
    1175                 1180                 1185             


Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys 
    1190                 1195                 1200             


Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu 
    1205                 1210                 1215             


Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys 
    1220                 1225                 1230             


Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr 
    1235                 1240                 1245             


Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn 
    1250                 1255                 1260             


Glu Gln  Lys Gln Leu Phe Val  Glu Gln His Lys His  Tyr Leu Asp 
    1265                 1270                 1275             


Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu 
    1280                 1285                 1290             


Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His 
    1295                 1300                 1305             


Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu 
    1310                 1315                 1320             


Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe 
    1325                 1330                 1335             


Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val 
    1340                 1345                 1350             


Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu 
    1355                 1360                 1365             


Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly Asp Pro  Lys Lys Lys 
    1370                 1375                 1380             


Arg Lys  Val Gly Ser Ala Gly  Ser Arg Leu Asp Ala  Pro Ser Gln 
    1385                 1390                 1395             


Ile Glu  Val Lys Asp Val Thr  Asp Thr Thr Ala Leu  Ile Thr Trp 
    1400                 1405                 1410             


Val Asp  Pro Arg Tyr Asp Asp  Ile Trp Trp Phe Glu  Leu Thr Tyr 
    1415                 1420                 1425             


Gly Ile  Lys Asp Val Pro Gly  Asp Arg Thr Thr Ile  Lys Leu Tyr 
    1430                 1435                 1440             


Leu Asn  Asp Pro Tyr Tyr Ser  Ile Gly Asn Leu Lys  Pro Asp Thr 
    1445                 1450                 1455             


Glu Tyr  Glu Val Ser Leu Ile  Ser Tyr Thr Gly Asp  Ser Tyr Ser 
    1460                 1465                 1470             


Arg Ser  Gly Ser Asn Pro Ala  Lys Ile Thr Phe Lys  Thr Gly Leu 
    1475                 1480                 1485             


Arg Leu  Asp Ala Pro Ser Gln  Ile Glu Val Lys Asp  Val Thr Asp 
    1490                 1495                 1500             


Thr Thr  Ala Leu Ile Thr Trp  Val Asp Pro Arg Tyr  Asp Asp Ile 
    1505                 1510                 1515             


Trp Trp  Phe Glu Leu Thr Tyr  Gly Ile Lys Asp Val  Pro Gly Asp 
    1520                 1525                 1530             


Arg Thr  Thr Ile Lys Leu Tyr  Leu Asn Asp Pro Tyr  Tyr Ser Ile 
    1535                 1540                 1545             


Gly Asn  Leu Lys Pro Asp Thr  Glu Tyr Glu Val Ser  Leu Ile Ser 
    1550                 1555                 1560             


Tyr Thr  Gly Asp Ser Tyr Ser  Arg Ser Gly Ser Asn  Pro Ala Lys 
    1565                 1570                 1575             


Ile Thr  Phe Lys Thr Gly Leu  Arg Leu Asp Ala Pro  Ser Gln Ile 
    1580                 1585                 1590             


Glu Val  Lys Asp Val Thr Asp  Thr Thr Ala Leu Ile  Thr Trp Val 
    1595                 1600                 1605             


Asp Pro  Arg Tyr Asp Asp Ile  Trp Trp Phe Glu Leu  Thr Tyr Gly 
    1610                 1615                 1620             


Ile Lys  Asp Val Pro Gly Asp  Arg Thr Thr Ile Lys  Leu Tyr Leu 
    1625                 1630                 1635             


Asn Asp  Pro Tyr Tyr Ser Ile  Gly Asn Leu Lys Pro  Asp Thr Glu 
    1640                 1645                 1650             


Tyr Glu  Val Ser Leu Ile Ser  Tyr Thr Gly Asp Ser  Tyr Ser Arg 
    1655                 1660                 1665             


Ser Gly  Ser Asn Pro Ala Lys  Ile Thr Phe Lys Thr  Gly Leu 
    1670                 1675                 1680         


<210>  228
<211>  5049
<212>  DNA
<213>  Artificial sequence

<220>
<223>  spdCas9-PRSIM_23x3

<400>  228
atggactatt acccctacga cgtgcccgat tacgccgaca agaagtattc tatcggactg       60

gccatcggga ctaatagcgt cgggtgggcc gtgatcactg acgagtacaa ggtgccctct      120

aagaagttca aggtgctcgg gaacaccgac cggcattcca tcaagaaaaa tctgatcgga      180

gctctcctct ttgattcagg ggaaaccgct gaagcaaccc gcctcaagcg gactgctaga      240

cggcggtaca ccaggaggaa gaaccggatt tgttaccttc aagagatatt ctccaacgaa      300

atggcaaagg tcgacgacag cttcttccat aggctggaag aatcattcct cgtggaagag      360

gataagaagc atgaacggca tcccatcttc ggtaatatcg tcgacgaggt ggcctatcac      420

gagaaatacc caaccatcta ccatcttcgc aaaaagctgg tggactcaac cgacaaggca      480

gacctccggc ttatctacct ggccctggcc cacatgatca agttcagagg ccacttcctg      540

atcgagggcg acctcaatcc tgacaatagc gatgtggata aactgttcat ccagctggtg      600

cagacttaca accagctctt tgaagagaac cccatcaatg caagcggagt cgatgccaag      660

gccattctgt cagcccggct gtcaaagagc cgcagacttg agaatcttat cgctcagctg      720

ccgggtgaaa agaaaaatgg actgttcggg aacctgattg ctctttcact tgggctgact      780

cccaatttca agtctaattt cgacctggca gaggatgcca agctgcaact gtccaaggac      840

acctatgatg acgatctcga caacctcctg gcccagatcg gtgaccaata cgccgacctt      900

ttccttgctg ctaagaatct ttctgacgcc atcctgctgt ctgacattct ccgcgtgaac      960

actgaaatca ccaaggcccc tctttcagct tcaatgatta agcggtatga tgagcaccac     1020

caggacctga ccctgcttaa ggcactcgtc cggcagcagc ttccggagaa gtacaaggaa     1080

atcttctttg accagtcaaa gaatggatac gccggctaca tcgacggagg tgcctcccaa     1140

gaggaatttt ataagtttat caaacctatc cttgagaaga tggacggcac cgaagagctc     1200

ctcgtgaaac tgaatcggga ggatctgctg cggaagcagc gcactttcga caatgggagc     1260

attccccacc agatccatct tggggagctt cacgccatcc ttcggcgcca agaggacttc     1320

tacccctttc ttaaggacaa cagggagaag attgagaaaa ttctcacttt ccgcatcccc     1380

tactacgtgg gacccctcgc cagaggaaat agccggtttg cttggatgac cagaaagtca     1440

gaagaaacta tcactccctg gaacttcgaa gaggtggtgg acaagggagc cagcgctcag     1500

tcattcatcg aacggatgac taacttcgat aagaacctcc ccaatgagaa ggtcctgccg     1560

aaacattccc tgctctacga gtactttacc gtgtacaacg agctgaccaa ggtgaaatat     1620

gtcaccgaag ggatgaggaa gcccgcattc ctgtcaggcg aacaaaagaa ggcaattgtg     1680

gaccttctgt tcaagaccaa tagaaaggtg accgtgaagc agctgaagga ggactatttc     1740

aagaaaattg aatgcttcga ctctgtggag attagcgggg tcgaagatcg gttcaacgca     1800

agcctgggta cctaccatga tctgcttaag atcatcaagg acaaggattt tctggacaat     1860

gaggagaacg aggacatcct tgaggacatt gtcctgactc tcactctgtt cgaggaccgg     1920

gaaatgatcg aggagaggct taagacctac gcccatctgt tcgacgataa agtgatgaag     1980

caacttaaac ggagaagata taccggatgg ggacgcctta gccgcaaact catcaacgga     2040

atccgggaca aacagagcgg aaagaccatt cttgatttcc ttaagagcga cggattcgct     2100

aatcgcaact tcatgcaact tatccatgat gattccctga cctttaagga ggacatccag     2160

aaggcccaag tgtctggaca aggtgactca ctgcacgagc atatcgcaaa tctggctggt     2220

tcacccgcta ttaagaaggg tattctccag accgtgaaag tcgtggacga gctggtcaag     2280

gtgatgggtc gccataaacc agagaacatt gtcatcgaga tggccaggga aaaccagact     2340

acccagaagg gacagaagaa cagcagggag cggatgaaaa gaattgagga agggattaag     2400

gagctcgggt cacagatcct taaagagcac ccggtggaaa acacccagct tcagaatgag     2460

aagctctatc tgtactacct tcaaaatgga cgcgatatgt atgtggacca agagcttgat     2520

atcaacaggc tctcagacta cgacgtggac gccatcgtcc ctcagagctt cctcaaagac     2580

gactcaattg acaataaggt gctgactcgc tcagacaaga accggggaaa gtcagataac     2640

gtgccctcag aggaagtcgt gaaaaagatg aagaactatt ggcgccagct tctgaacgca     2700

aagctgatca ctcagcggaa gttcgacaat ctcactaagg ctgagagggg cggactgagc     2760

gaactggaca aagcaggatt cattaaacgg caacttgtgg agactcggca gattactaaa     2820

catgtcgccc aaatccttga ctcacgcatg aataccaagt acgacgaaaa cgacaaactt     2880

atccgcgagg tgaaggtgat taccctgaag tccaagctgg tcagcgattt cagaaaggac     2940

tttcaattct acaaagtgcg ggagatcaat aactatcatc atgctcatga cgcatatctg     3000

aatgccgtgg tgggaaccgc cctgatcaag aagtacccaa agctggaaag cgagttcgtg     3060

tacggagact acaaggtcta cgacgtgcgc aagatgattg ccaaatctga gcaggagatc     3120

ggaaaggcca ccgcaaagta cttcttctac agcaacatca tgaatttctt caagaccgaa     3180

atcacccttg caaacggtga gatccggaag aggccgctca tcgagactaa tggggagact     3240

ggcgaaatcg tgtgggacaa gggcagagat ttcgctaccg tgcgcaaagt gctttctatg     3300

cctcaagtga acatcgtgaa gaaaaccgag gtgcaaaccg gaggcttttc taaggaatca     3360

atcctcccca agcgcaactc cgacaagctc attgcaagga agaaggattg ggaccctaag     3420

aagtacggcg gattcgattc accaactgtg gcttattctg tcctggtcgt ggctaaggtg     3480

gaaaaaggaa agtctaagaa gctcaagagc gtgaaggaac tgctgggtat caccattatg     3540

gagcgcagct ccttcgagaa gaacccaatt gactttctcg aagccaaagg ttacaaggaa     3600

gtcaagaagg accttatcat caagctccca aagtatagcc tgttcgaact ggagaatggg     3660

cggaagcgga tgctcgcctc cgctggcgaa cttcagaagg gtaatgagct ggctctcccc     3720

tccaagtacg tgaatttcct ctaccttgca agccattacg agaagctgaa ggggagcccc     3780

gaggacaacg agcaaaagca actgtttgtg gagcagcata agcattatct ggacgagatc     3840

attgagcaga tttccgagtt ttctaaacgc gtcattctcg ctgatgccaa cctcgataaa     3900

gtccttagcg catacaataa gcacagagac aaaccaattc gggagcaggc tgagaatatc     3960

atccacctgt tcaccctcac caatcttggt gcccctgccg cattcaagta cttcgacacc     4020

accatcgacc ggaaacgcta tacctccacc aaagaagtgc tggacgccac cctcatccac     4080

cagagcatca ccggacttta cgaaactcgg attgacctct cacagctcgg aggggatccc     4140

aagaagaagc ggaaagtcgg cagcgctggc tctagactgg atgcccctag ccagatcgaa     4200

gtgaaggacg tgaccgacac caccgctctg atcacctggg ttgaccccag atacgacgac     4260

atctggtggt tcgagctgac ctacggcatc aaggatgtgc ccggcgacag aaccaccatc     4320

aagctgtacc tgaacgaccc ctactacagc atcggcaacc tgaagcctga caccgagtac     4380

gaggtgtccc tgatcagcta caccggcgac tcctacagca gaagcggcag caatcctgcc     4440

aagatcacct tcaagaccgg cctgagactg gacgcaccct ctcagattga agtcaaagat     4500

gtcaccgaca cgacagccct gattacatgg gttgaccctc gctacgatga tatttggtgg     4560

tttgaactca cgtacgggat caaagacgtg ccaggggatc gcacaacaat caagctctat     4620

ctcaatgatc cgtactactc catcgggaat ctgaaacccg atacagagta cgaagtctcc     4680

ctcatctctt acaccgggga cagctactcc agatccggct ccaatccagc caaaattacg     4740

tttaagacag gcctgcggct ggatgctcca tctcaaatag aagttaagga tgtgacggat     4800

acgacggccc tcatcacttg ggttgaccct cgatatgacg atatttggtg gttcgaattg     4860

acgtatggca ttaaggacgt cccaggcgac cggacaacta ttaagctgta tcttaacgat     4920

ccttattata gcatcggaaa tctcaagccg gataccgaat atgaggtttc cctcatttcc     4980

tatactgggg actcctactc tcgctccggc tctaacccag ctaagatcac ttttaaaacc     5040

gggctttaa                                                             5049


<210>  229
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gRNA IL-2

<400>  229
gttacattag cccacactt                                                    19


<210>  230
<211>  591
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PRSIM23_NS4A/3 PR S139A_DCasp9 (S196A)

<400>  230

Met Gly Ser Arg Leu Asp Ala Pro Ser Gln Ile Glu Val Lys Asp Val 
1               5                   10                  15      


Thr Asp Thr Thr Ala Leu Ile Thr Trp Val Asp Pro Arg Tyr Asp Asp 
            20                  25                  30          


Ile Trp Trp Phe Glu Leu Thr Tyr Gly Ile Lys Asp Val Pro Gly Asp 
        35                  40                  45              


Arg Thr Thr Ile Lys Leu Tyr Leu Asn Asp Pro Tyr Tyr Ser Ile Gly 
    50                  55                  60                  


Asn Leu Lys Pro Asp Thr Glu Tyr Glu Val Ser Leu Ile Ser Tyr Thr 
65                  70                  75                  80  


Gly Asp Ser Tyr Ser Arg Ser Gly Ser Asn Pro Ala Lys Ile Thr Phe 
                85                  90                  95      


Lys Thr Gly Leu Gly Gly Gly Ser Gly Met Lys Lys Lys Gly Ser Val 
            100                 105                 110         


Val Ile Val Gly Arg Ile Asn Leu Ser Gly Asp Thr Ala Tyr Ala Gln 
        115                 120                 125             


Gln Thr Arg Gly Glu Glu Gly Cys Gln Glu Thr Ser Gln Thr Gly Arg 
    130                 135                 140                 


Asp Lys Asn Gln Val Glu Gly Glu Val Gln Ile Val Ser Thr Ala Thr 
145                 150                 155                 160 


Gln Thr Phe Leu Ala Thr Ser Ile Asn Gly Val Leu Trp Thr Val Tyr 
                165                 170                 175     


His Gly Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Thr 
            180                 185                 190         


Gln Met Tyr Thr Asn Val Asp Lys Asp Leu Val Gly Trp Gln Ala Pro 
        195                 200                 205             


Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu 
    210                 215                 220                 


Tyr Leu Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly 
225                 230                 235                 240 


Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys 
                245                 250                 255     


Gly Ser Ala Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly 
            260                 265                 270         


Ile Phe Arg Ala Ala Val Ser Thr Arg Gly Val Ala Lys Ala Val Asp 
        275                 280                 285             


Phe Ile Pro Val Glu Ser Leu Glu Thr Thr Met Arg Ser Pro Gly Gly 
    290                 295                 300                 


Gly Ser Gly Val Asp Gly Phe Gly Asp Val Gly Ala Leu Glu Ser Leu 
305                 310                 315                 320 


Arg Gly Asn Ala Asp Leu Ala Tyr Ile Leu Ser Met Glu Pro Cys Gly 
                325                 330                 335     


His Cys Leu Ile Ile Asn Asn Val Asn Phe Cys Arg Glu Ser Gly Leu 
            340                 345                 350         


Arg Thr Arg Thr Gly Ser Asn Ile Asp Cys Glu Lys Leu Arg Arg Arg 
        355                 360                 365             


Phe Ser Ala Leu His Phe Met Val Glu Val Lys Gly Asp Leu Thr Ala 
    370                 375                 380                 


Lys Lys Met Val Leu Ala Leu Leu Glu Leu Ala Arg Gln Asp His Gly 
385                 390                 395                 400 


Ala Leu Asp Cys Cys Val Val Val Ile Leu Ser His Gly Cys Gln Ala 
                405                 410                 415     


Ser His Leu Gln Phe Pro Gly Ala Val Tyr Gly Thr Asp Gly Cys Pro 
            420                 425                 430         


Val Ser Val Glu Lys Ile Val Asn Ile Phe Asn Gly Thr Ser Cys Pro 
        435                 440                 445             


Ser Leu Gly Gly Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Gly Gly 
    450                 455                 460                 


Glu Gln Lys Asp His Gly Phe Glu Val Ala Ser Thr Ser Pro Glu Asp 
465                 470                 475                 480 


Glu Ser Pro Gly Ser Asn Pro Glu Pro Asp Ala Thr Pro Phe Gln Glu 
                485                 490                 495     


Gly Leu Arg Thr Phe Asp Gln Leu Asp Ala Ile Ser Ser Leu Pro Thr 
            500                 505                 510         


Pro Ser Asp Ile Phe Val Ser Tyr Ser Thr Phe Pro Gly Phe Val Ser 
        515                 520                 525             


Trp Arg Asp Pro Lys Ser Gly Ser Trp Tyr Val Glu Thr Leu Asp Asp 
    530                 535                 540                 


Ile Phe Glu Gln Trp Ala His Ser Glu Asp Leu Gln Ser Leu Leu Leu 
545                 550                 555                 560 


Arg Val Ala Asn Ala Val Ser Val Lys Gly Ile Tyr Lys Gln Met Pro 
                565                 570                 575     


Gly Cys Phe Asn Phe Leu Arg Lys Lys Leu Phe Phe Lys Thr Ser 
            580                 585                 590     


<210>  231
<211>  1779
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PRSIM23_NS4A/3 PR S139A_DCasp9 (S196A)

<400>  231
atgggctcta gactggatgc ccctagccag atcgaagtga aggacgtgac cgacaccacc       60

gctctgatca cctgggttga ccccagatac gacgatatct ggtggttcga gctgacctac      120

ggcatcaagg atgtgcccgg cgacagaacc accatcaagc tgtacctgaa cgacccctac      180

tacagcatcg gcaacctgaa gcctgacacc gagtacgagg tgtccctgat cagctacacc      240

ggcgactcct acagcagaag cggcagcaat cctgccaaga tcaccttcaa gaccggcctt      300

gggggcggat ccggcatgaa gaaaaagggc tctgtggtca tcgtgggcag aatcaacctg      360

agcggcgata ccgcctacgc tcagcagaca agaggcgagg aaggctgcca agagacaagc      420

cagaccggca gagacaagaa ccaggtggaa ggcgaggtgc agatcgtgtc tacagctacc      480

cagaccttcc tggccaccag catcaatggc gtgctgtgga cagtgtatca cggcgctggc      540

accagaacaa tcgcctctcc aaagggcccc gtgacacaga tgtacaccaa cgtggacaag      600

gacctcgtcg gatggcaagc ccctcagggc tctagaagcc tgacaccttg tacctgcggc      660

agcagcgatc tgtacctggt cacaagacac gccgacgtga tccccgtcag aagaagaggc      720

gatagcagag gcagcctgct gagccctaga cctatcagct acctgaaggg atctgccggc      780

ggacctctgc tttgtcctgc tggacatgcc gtgggcatct ttagagccgc cgtgtctact      840

agaggcgtgg ccaaagccgt ggacttcatc cctgtggaaa gcctggaaac caccatgcgg      900

agccccgggg gaggctccgg cgtggatggc tttggagatg tgggcgccct ggaatccctg      960

agaggaaatg ccgatctggc ctacatcctg agcatggaac cttgcggcca ctgcctgatt     1020

atcaacaatg tgaacttctg ccgcgagagc ggcctgagaa caagaaccgg cagcaacatc     1080

gattgcgaga agctgcggag aagattcagc gccctgcact tcatggtgga agtgaagggc     1140

gacctgaccg ccaagaaaat ggtgctggct ctgctggaac tggccagaca ggatcatggc     1200

gcactggatt gctgcgtggt cgtgattctg agccacggct gtcaggccag ccatctgcaa     1260

ttccctggcg ccgtgtatgg caccgatggc tgtcctgtgt ccgtggaaaa gatcgtgaac     1320

atcttcaacg gcaccagctg tcctagcctc ggcggaaagc ccaagctgtt cttcatccaa     1380

gcctgtggcg gcgagcagaa ggatcacgga tttgaggtgg ccagcacaag ccccgaggat     1440

gagagccctg gaagcaaccc tgagcctgac gccacacctt tccaagaggg actgagaacc     1500

ttcgaccagc tggacgctat cagctccctg cctacaccta gcgacatctt cgtgtcctac     1560

agcacattcc ccggctttgt gtcttggcgg gaccccaagt ctggctcttg gtacgtggaa     1620

accctggatg acatcttcga gcagtgggcc catagcgagg acctgcaatc tctgctgctg     1680

agagtggcca atgccgtgtc cgtgaagggc atctacaagc agatgcccgg ctgcttcaac     1740

ttcctgcgga agaagctgtt tttcaagacc agctgatag                            1779


<210>  232
<211>  834
<212>  DNA
<213>  Artificial sequence

<220>
<223>  GFP-PEST

<400>  232
atggaaagcg acgagtctgg cctgcctgct atggaaatcg agtgccggat caccggcaca       60

ctgaacggcg tggaattcga actcgttggc ggcggagagg gcacacctga acagggcaga      120

atgaccaaca agatgaagtc caccaaaggc gccctgacat tcagccccta cctgctgtct      180

cacgtgatgg gctacggctt ctaccacttc ggcacatacc ctagcggcta cgagaaccct      240

ttcctgcacg ccatcaacaa cggcggctac accaacacca gaatcgagaa gtacgaggac      300

ggcggcgtgc tgcacgtgtc cttcagctac agatatgagg ccggcagagt gatcggcgac      360

ttcaaagtga tgggcaccgg atttcccgag gacagcgtga tcttcaccga caagatcatc      420

cggtccaacg ccaccgtgga acatctgcac cctatgggcg acaacgacct ggatggcagc      480

ttcaccagaa ccttcagcct gagagatggc ggctactaca gcagcgtggt ggacagccac      540

atgcacttca agagcgccat ccatcctagc atcctgcaga acggcggacc catgttcgcc      600

ttcagaagag tggaagagga ccacagcaac accgagctgg gcatcgtgga ataccagcac      660

gccttcaaga cccctgatgc cgatgccggc gaggaaagaa gcagagatat cagccacggc      720

ttcccaccag ctgtggccgc tcaagatgat ggcacactgc ctatgagctg cgcccaagag      780

tccggcatgg atagacatcc tgccgcctgt gccagcgcca gaatcaatgt gtaa            834


<210>  233
<211>  277
<212>  PRT
<213>  Artificial sequence

<220>
<223>  GFP-PEST

<400>  233

Met Glu Ser Asp Glu Ser Gly Leu Pro Ala Met Glu Ile Glu Cys Arg 
1               5                   10                  15      


Ile Thr Gly Thr Leu Asn Gly Val Glu Phe Glu Leu Val Gly Gly Gly 
            20                  25                  30          


Glu Gly Thr Pro Glu Gln Gly Arg Met Thr Asn Lys Met Lys Ser Thr 
        35                  40                  45              


Lys Gly Ala Leu Thr Phe Ser Pro Tyr Leu Leu Ser His Val Met Gly 
    50                  55                  60                  


Tyr Gly Phe Tyr His Phe Gly Thr Tyr Pro Ser Gly Tyr Glu Asn Pro 
65                  70                  75                  80  


Phe Leu His Ala Ile Asn Asn Gly Gly Tyr Thr Asn Thr Arg Ile Glu 
                85                  90                  95      


Lys Tyr Glu Asp Gly Gly Val Leu His Val Ser Phe Ser Tyr Arg Tyr 
            100                 105                 110         


Glu Ala Gly Arg Val Ile Gly Asp Phe Lys Val Met Gly Thr Gly Phe 
        115                 120                 125             


Pro Glu Asp Ser Val Ile Phe Thr Asp Lys Ile Ile Arg Ser Asn Ala 
    130                 135                 140                 


Thr Val Glu His Leu His Pro Met Gly Asp Asn Asp Leu Asp Gly Ser 
145                 150                 155                 160 


Phe Thr Arg Thr Phe Ser Leu Arg Asp Gly Gly Tyr Tyr Ser Ser Val 
                165                 170                 175     


Val Asp Ser His Met His Phe Lys Ser Ala Ile His Pro Ser Ile Leu 
            180                 185                 190         


Gln Asn Gly Gly Pro Met Phe Ala Phe Arg Arg Val Glu Glu Asp His 
        195                 200                 205             


Ser Asn Thr Glu Leu Gly Ile Val Glu Tyr Gln His Ala Phe Lys Thr 
    210                 215                 220                 


Pro Asp Ala Asp Ala Gly Glu Glu Arg Ser Arg Asp Ile Ser His Gly 
225                 230                 235                 240 


Phe Pro Pro Ala Val Ala Ala Gln Asp Asp Gly Thr Leu Pro Met Ser 
                245                 250                 255     


Cys Ala Gln Glu Ser Gly Met Asp Arg His Pro Ala Ala Cys Ala Ser 
            260                 265                 270         


Ala Arg Ile Asn Val 
        275         


<210>  234
<211>  490
<212>  DNA
<213>  Artificial sequence

<220>
<223>  hAAV1 left homologous arm

<400>  234
gagcacttcc ttctcggcgc tgcaccacgt gatgtcctct gagcggatcc tccccgtgtc       60

tgggtcctct ccgggcatct ctcctccctc acccaacccc atgccgtctt cactcgctgg      120

gttccctttt ccttctcctt ctggggcctg tgccatctct cgtttcttag gatggccttc      180

tccgacggat gtctcccttg cgtcccgcct ccccttcttg taggcctgca tcatcaccgt      240

ttttctggac aaccccaaag taccccgtct ccctggcttt agccacctct ccatcctctt      300

gctttctttg cctggacacc ccgttctcct gtggattcgg gtcacctctc actcctttca      360

tttgggcagc tcccctaccc cccttacctc tctagtctgt gctagctctt ccagccccct      420

gtcatggcat cttccagggg tccgagagct cagctagtct tcttcctcca acccgggccc      480

ctatgtccac                                                             490


<210>  235
<211>  527
<212>  DNA
<213>  Artificial sequence

<220>
<223>  hAAV1 Right Homologous arm

<400>  235
gatcctggga gggagagctt ggcagggggt gggagggaag ggggggatgc gtgacctgcc       60

cggttctcag tggccaccct gcgctaccct ctcccagaac ctgagctgct ctgacgcggc      120

cgtctggtgc gtttcactga tcctggtgct gcagcttcct tacacttccc aagaggagaa      180

gcagtttgga aaaacaaaat cagaataagt tggtcctgag ttctaacttt ggctcttcac      240

ctttctagtc cccaatttat attgttcctc cgtgcgtcag ttttacctgt gagataaggc      300

cagtagccag ccccgtcctg gcagggctgt ggtgaggagg ggggtgtccg tgtggaaaac      360

tccctttgtg agaatggtgc gtcctaggtg ttcaccaggt cgtggccgcc tctactccct      420

ttctctttct ccatccttct ttccttaaag agtccccagt gctatctggg acatattcct      480

ccgcccagag cagggtcccg cttccctaag gccctgctct gtctaga                    527


<210>  236
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  gRNA AAVS1

<400>  236
gttaatgtgg ctctggttct                                                   20


<210>  237
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MEDI8852 heavy chain

<400>  237
caggttcagc tgcagcagtc tggacctggc ctggtcaagc ctagccagac actgtctctg       60

acctgtgcca tcagcggcga tagcgtgtcc agctacaacg ccgtgtggaa ctggatcaga      120

cagagcccta gcagaggcct ggaatggctg ggcagaacct actacagaag cggctggtac      180

aacgactacg ccgagagcgt gaagtcccgg atcaccatca atcccgacac cagcaagaac      240

cagttcagcc tccagctgaa cagcgtgacc cctgaggata ccgccgtgta ctactgtgcc      300

agatccggcc acatcaccgt gttcggagtg aacgtggacg ccttcgatat gtggggccag      360

ggcacaatgg tcaccgtgtc tagcgcctct acaaagggcc ctagcgtgtt ccctctggct      420

cctagcagca agtctacaag cggaggaaca gccgctctgg gctgcctcgt gaaggattac      480

tttcccgagc ctgtgaccgt gtcctggaat tctggcgctc tgacaagcgg cgtgcacacc      540

tttccagctg tgctgcaaag cagcggcctg tactctctga gcagcgtggt cacagtgcca      600

agctctagcc tgggcaccca gacctacatc tgcaatgtga atcacaagcc cagcaacacc      660

aaggtggaca agagagtgga acccaagagc tgcgacaaga cccacacctg tcctccatgt      720

cctgctccag aactgctcgg cggaccttcc gtgttcctgt ttcctccaaa gcctaaggac      780

accctgatga tcagcagaac ccctgaagtg acctgcgtgg tggtggatgt gtctcacgag      840

gaccccgaag tgaagttcaa ttggtacgtg gacggcgtgg aagtgcacaa cgccaagacc      900

aagcctagag aggaacagta caacagcacc tacagagtgg tgtccgtgct gaccgtgctg      960

caccaggatt ggctgaacgg caaagagtac aagtgcaagg tgtccaacaa ggccctgcct     1020

gctcctatcg agaaaaccat cagcaaggcc aagggccagc ctagggaacc ccaggtttac     1080

acactgcctc caagccggga agagatgacc aagaatcagg tgtccctgac ctgcctggtt     1140

aagggcttct acccctccga tatcgccgtg gaatgggaga gcaatggcca gcctgagaac     1200

aactacaaga caacccctcc tgtgctggac agcgacggct cattcttcct gtacagcaag     1260

ctgacagtgg acaagtccag atggcagcag ggcaacgtgt tctcctgcag cgtgatgcac     1320

gaggccctgc acaaccacta cacccagaag tccctgagcc tgtctcctgg caaa           1374


<210>  238
<211>  630
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MEDI8852 light chain

<400>  238
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc       60

atcacctgta gaaccagcca gagcctgagc agctacaccc actggtatca gcagaagcct      120

ggcaaggccc ctaagctgct gatctatgcc gccagctcta gaggcagcgg agtgccttct      180

agattttccg gcagcggctc cggcaccgat ttcaccctga ccatatctag cctgcagcct      240

gaggacttcg ccacctacta ctgccagcag agcagaacct ttggccaggg caccaaggtg      300

gaaatcaagc ggacagtggc cgctcctagc gtgttcatct ttccacctag cgacgagcag      360

ctgaagtctg gcacagcctc tgtcgtgtgc ctgctgaaca acttctaccc cagagaagcc      420

aaggtgcagt ggaaggtgga caacgccctg cagagcggca atagccaaga gagcgtgacc      480

gagcaggaca gcaaggactc tacctactct ctgagcagca ccctgacact gagcaaggcc      540

gactacgaga agcacaaagt gtacgcctgc gaagtgaccc accagggcct ttctagccct      600

gtgaccaaga gcttcaaccg gggcgaatgt                                       630


<210>  239
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  239

Gly Gly Gly Ser 
1               


<210>  240
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  240

Gly Gly Gly Gly Ser 
1               5   


<210>  241
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  241

Gly Gly Ser Gly 
1               


<210>  242
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  242

Gly Ser Gly Gly 
1               


<210>  243
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  243

Ser Gly Gly Gly 
1               


<210>  244
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  244

Ser Ser Gly Gly 
1               


<210>  245
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  245

Ser Ser Ser Gly 
1               


<210>  246
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M_LHA_PF2

<400>  246
gggaggaact tcttggcaca                                                   20


<210>  247
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M_RHA_PR2

<400>  247
aggagagact cacgctggat                                                   20


