                         SEQUENCE LISTING

<110>  Intervet Inc.
       Intervet International BV
       Morsey, Mohamad
       Zhang, Yuanzheng
       Tarpey, Ian
 
<120>  Caninized Antibodies to Human CTLA-4

<130>  24721-US-PCT

<150>  62/874287
<151>  2019-07-15

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  murine-canine chimera

<400>  1
gaagtgcagc tgcagcagtt tggcgcggaa ctggtgaaac cgggcgcgag cgtgaaaatg       60

agctgcaaag cgagcggcta tacctttacc gattataaca tggattgggt gcgccagagc      120

ggcaaaagcc tggaatggat tggcaacatt aacccgaaca gcgaaagcac cagctataac      180

cagaaattta aaggcaaagc gaccctgacc gtggataaaa gcagcagcac cgcgtatatg      240

gaactgcgca gcctgaccag cgatgatacc gcggtgtatt attgcacccg cgatggcaac      300

cgctatgatg cgtggtttgc gtattggggc cagggcaccc tggtgaccgt gagcagcgcg      360

agcaccaccg cgccgagcgt gtttccgctg gcgccgagct gcggcagcac cagcggcagc      420

accgtggcgc tggcgtgcct ggtgagcggc tattttccgg aaccggtgac cgtgagctgg      480

aacagcggca gcctgaccag cggcgtgcat acctttccga gcgtgctgca gagcagcggc      540

ctgtatagcc tgagcagcat ggtgaccgtg ccgagcagcc gctggccgag cgaaaccttt      600

acctgcaacg tggcgcatcc ggcgagcaaa accaaagtgg ataaaccggt gccgaaacgc      660

gaaaacggcc gcgtgccgcg cccgccggat tgcccgaaat gcccggcgcc ggaaatgctg      720

ggcggcccga gcgtgtttat ttttccgccg aaaccgaaag ataccctgct gattgcgcgc      780

accccggaag tgacctgcgt ggtggtggcg ctggatccgg aagatccgga agtgcagatt      840

agctggtttg tggatggcaa acagatgcag accgcgaaaa cccagccgcg cgaagaacag      900

tttgcgggca cctatcgcgt ggtgagcgtg ctgccgattg gccatcagga ttggctgaaa      960

ggcaaacagt ttacctgcaa agtgaacaac aaagcgctgc cgagcccgat tgaacgcacc     1020

attagcaaag cgcgcggcca ggcgcatcag ccgagcgtgt atgtgctgcc gccgagccgc     1080

gaagaactga gcaaaaacac cgtgagcctg acctgcctga ttaaagattt ttttccgccg     1140

gatattgatg tggaatggca gagcaacggc cagcaggaac cggaaagcaa atatcgcacc     1200

accccgccgc agctggatga agatggcagc tattttctgt atagcaaact gagcgtggat     1260

aaaagccgct ggcagcgcgg cgataccttt atttgcgcgg tgatgcatga agcgctgcat     1320

aaccattata cccaggaaag cctgagccat agcccgggca aa                        1362


<210>  2
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine-canine chimera

<400>  2

Glu Val Gln Leu Gln Gln Phe Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Arg Gln Ser Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Asn Ile Asn Pro Asn Ser Glu Ser Thr Ser Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Asp Gly Asn Arg Tyr Asp Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu 
    130                 135                 140                 


Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser 
            180                 185                 190         


Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala 
        195                 200                 205             


Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg 
    210                 215                 220                 


Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu Asp 
            260                 265                 270         


Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln 
        275                 280                 285             


Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys 
305                 310                 315                 320 


Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro 
                325                 330                 335     


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
            340                 345                 350         


Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val 
    370                 375                 380                 


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr 
385                 390                 395                 400 


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys 
            420                 425                 430         


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu 
        435                 440                 445             


Ser His Ser Pro Gly Lys 
    450                 


<210>  3
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  murine-canine chimera

<400>  3
cagattgtgc tgacccagag cccggcgatt atgagcgcga gcccgggcga aaaagtgacc       60

atgacctgca gcgcgagcag cagcgtgacc tatatgcatt ggtttcagca gaaaccgggc      120

accagcccga aactgtggat ttatagcacc agcattctgg cgagcggcgt gccggcgcgc      180

tttagcggca gcggcagcgg caccagctat agcctgacca ttagccgcat ggaagcggaa      240

gatgcggcga cctattattg ccagcagcgc accagctatc cgctgacctt tggcaccggc      300

accaaactgg aactgaaacg caacgatgcg cagccggcgg tgtatctgtt tcagccgagc      360

ccggatcagc tgcataccgg cagcgcgagc gtggtgtgcc tgctgaacag cttttatccg      420

aaagatatta acgtgaaatg gaaagtggat ggcgtgattc aggataccgg cattcaggaa      480

agcgtgaccg aacaggatag caaagatagc acctatagcc tgagcagcac cctgaccatg      540

agcagcaccg aatatctgag ccatgaactg tatagctgcg aaattaccca taaaagcctg      600

ccgagcaccc tgattaaaag ctttcagcgc agcgaatgcc agcgcgtgga t               651


<210>  4
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine-canine chimera

<400>  4

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Ile Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Thr Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Thr Gly Thr Lys Leu Glu Leu Lys Arg Asn Asp Ala Gln Pro 
            100                 105                 110         


Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly Ser 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  5
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  murine-canine chimera

<400>  5
caggtgcagc tgcagcagag cggcgatgat ctggtgaaac cgggcgcgag cgtgaaactg       60

agctgcaaag cgagcggcta tacctttacc agctattgga ttaactggat taaacagcgc      120

ccgggccagg gcctggaatg gattggccgc attgcgccgg gcagcggcac cacctattat      180

aacgaagtgt ttaaaggcaa agcgaccctg accgtggata aatatagcag caccgcgtat      240

attcagctga gcagcctgag cagcgaagat agcgcggtgt atttttgcgc gcgcggcgat      300

tatggcagct attggggcca gggcaccctg gtgaccgtga gcagcgcgag caccaccgcg      360

ccgagcgtgt ttccgctggc gccgagctgc ggcagcacca gcggcagcac cgtggcgctg      420

gcgtgcctgg tgagcggcta ttttccggaa ccggtgaccg tgagctggaa cagcggcagc      480

ctgaccagcg gcgtgcatac ctttccgagc gtgctgcaga gcagcggcct gtatagcctg      540

agcagcatgg tgaccgtgcc gagcagccgc tggccgagcg aaacctttac ctgcaacgtg      600

gcgcatccgg cgagcaaaac caaagtggat aaaccggtgc cgaaacgcga aaacggccgc      660

gtgccgcgcc cgccggattg cccgaaatgc ccggcgccgg aaatgctggg cggcccgagc      720

gtgtttattt ttccgccgaa accgaaagat accctgctga ttgcgcgcac cccggaagtg      780

acctgcgtgg tggtggcgct ggatccggaa gatccggaag tgcagattag ctggtttgtg      840

gatggcaaac agatgcagac cgcgaaaacc cagccgcgcg aagaacagtt tgcgggcacc      900

tatcgcgtgg tgagcgtgct gccgattggc catcaggatt ggctgaaagg caaacagttt      960

acctgcaaag tgaacaacaa agcgctgccg agcccgattg aacgcaccat tagcaaagcg     1020

cgcggccagg cgcatcagcc gagcgtgtat gtgctgccgc cgagccgcga agaactgagc     1080

aaaaacaccg tgagcctgac ctgcctgatt aaagattttt ttccgccgga tattgatgtg     1140

gaatggcaga gcaacggcca gcaggaaccg gaaagcaaat atcgcaccac cccgccgcag     1200

ctggatgaag atggcagcta ttttctgtat agcaaactga gcgtggataa aagccgctgg     1260

cagcgcggcg atacctttat ttgcgcggtg atgcatgaag cgctgcataa ccattatacc     1320

caggaaagcc tgagccatag cccgggcaaa                                      1350


<210>  6
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine-canine chimera

<400>  6

Gln Val Gln Leu Gln Gln Ser Gly Asp Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Ala Pro Gly Ser Gly Thr Thr Tyr Tyr Asn Glu Val Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Tyr Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Ser Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Gly Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val 
    130                 135                 140                 


Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro 
            180                 185                 190         


Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr Lys 
        195                 200                 205             


Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro 
    210                 215                 220                 


Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Ala Leu Asp Pro Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala 
        275                 280                 285             


Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe 
305                 310                 315                 320 


Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr 
                325                 330                 335     


Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser 
    370                 375                 380                 


Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln 
385                 390                 395                 400 


Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  7
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  murine-canine chimera

<400>  7
cagattgtgc tgacccagag cccggcgatt atgagcgcga gcccgggcga aaaagtgacc       60

atgacctgca gcgcgagcag cagcattagc tatatgcatt ggtttcagca gaaaccgggc      120

accagcccga aacgctggat ttatgatacc agcaaactgg cgagcggcgt gccggcgcgc      180

tttagcggca gcggcagcgg caccagctat agcctgacca ttaacagcat ggaagcggaa      240

gatgcggcga cctattattg ccatcagcgc accagctatc cgctgacctt tggcgcgggc      300

accaaactgg aactgaaacg caacgatgcg cagccggcgg tgtatctgtt tcagccgagc      360

ccggatcagc tgcataccgg cagcgcgagc gtggtgtgcc tgctgaacag cttttatccg      420

aaagatatta acgtgaaatg gaaagtggat ggcgtgattc aggataccgg cattcaggaa      480

agcgtgaccg aacaggatag caaagatagc acctatagcc tgagcagcac cctgaccatg      540

agcagcaccg aatatctgag ccatgaactg tatagctgcg aaattaccca taaaagcctg      600

ccgagcaccc tgattaaaag ctttcagcgc agcgaatgcc agcgcgtgga t               651


<210>  8
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine-canine chimera

<400>  8

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Arg Thr Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Asn Asp Ala Gln Pro 
            100                 105                 110         


Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly Ser 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  9
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human-canine chimera

<400>  9
caggtgcagc tggtggaaag cggcggcggc gtggtgcagc cgggccgcag cctgcgcctg       60

agctgcgtgg cgagcggctt tacctttagc agccatggca tgcattgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtggcggtg atttggtatg atggccgcaa caaatattat      180

gcggatagcg tgaaaggccg ctttaccatt agccgcgata acagcaaaaa caccctgttt      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgcggcggc      300

cattttggcc cgtttgatta ttggggccag ggcaccctgg tgaccgtgag cagcgcgagc      360

accaccgcgc cgagcgtgtt tccgctggcg ccgagctgcg gcagcaccag cggcagcacc      420

gtggcgctgg cgtgcctggt gagcggctat tttccggaac cggtgaccgt gagctggaac      480

agcggcagcc tgaccagcgg cgtgcatacc tttccgagcg tgctgcagag cagcggcctg      540

tatagcctga gcagcatggt gaccgtgccg agcagccgct ggccgagcga aacctttacc      600

tgcaacgtgg cgcatccggc gagcaaaacc aaagtggata aaccggtgcc gaaacgcgaa      660

aacggccgcg tgccgcgccc gccggattgc ccgaaatgcc cggcgccgga aatgctgggc      720

ggcccgagcg tgtttatttt tccgccgaaa ccgaaagata ccctgctgat tgcgcgcacc      780

ccggaagtga cctgcgtggt ggtggcgctg gatccggaag atccggaagt gcagattagc      840

tggtttgtgg atggcaaaca gatgcagacc gcgaaaaccc agccgcgcga agaacagttt      900

gcgggcacct atcgcgtggt gagcgtgctg ccgattggcc atcaggattg gctgaaaggc      960

aaacagttta cctgcaaagt gaacaacaaa gcgctgccga gcccgattga acgcaccatt     1020

agcaaagcgc gcggccaggc gcatcagccg agcgtgtatg tgctgccgcc gagccgcgaa     1080

gaactgagca aaaacaccgt gagcctgacc tgcctgatta aagatttttt tccgccggat     1140

attgatgtgg aatggcagag caacggccag caggaaccgg aaagcaaata tcgcaccacc     1200

ccgccgcagc tggatgaaga tggcagctat tttctgtata gcaaactgag cgtggataaa     1260

agccgctggc agcgcggcga tacctttatt tgcgcggtga tgcatgaagc gctgcataac     1320

cattataccc aggaaagcct gagccatagc ccgggcaaa                            1359


<210>  10
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human-canine chimera

<400>  10

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly His Phe Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala 
    130                 135                 140                 


Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser 
            180                 185                 190         


Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser 
        195                 200                 205             


Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val 
    210                 215                 220                 


Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu 
                245                 250                 255     


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu Asp Pro 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met 
        275                 280                 285             


Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly 
305                 310                 315                 320 


Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile 
                325                 330                 335     


Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val 
            340                 345                 350         


Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu 
    370                 375                 380                 


Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr 
385                 390                 395                 400 


Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser 
        435                 440                 445             


His Ser Pro Gly Lys 
    450             


<210>  11
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human-canine chimera

<400>  11
gaaattgtgc tgacccagag cccgggcacc ctgagcctga gcccgggcga acgcgcgacc       60

ctgagctgcc gcgcgagcca gagcattagc agcagctttc tggcgtggta tcagcagcgc      120

ccgggccagg cgccgcgcct gctgatttat ggcgcgagca gccgcgcgac cggcattccg      180

gatcgcttta gcggcagcgg cagcggcacc gattttaccc tgaccattag ccgcctggaa      240

ccggaagatt ttgcggtgta ttattgccag cagtatggca ccagcccgtg gacctttggc      300

cagggcacca aagtggaaat taaacgcaac gatgcgcagc cggcggtgta tctgtttcag      360

ccgagcccgg atcagctgca taccggcagc gcgagcgtgg tgtgcctgct gaacagcttt      420

tatccgaaag atattaacgt gaaatggaaa gtggatggcg tgattcagga taccggcatt      480

caggaaagcg tgaccgaaca ggatagcaaa gatagcacct atagcctgag cagcaccctg      540

accatgagca gcaccgaata tctgagccat gaactgtata gctgcgaaat tacccataaa      600

agcctgccga gcaccctgat taaaagcttt cagcgcagcg aatgccagcg cgtggat         657


<210>  12
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human-canine chimera

<400>  12

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Ser 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Thr Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Asn Asp Ala 
            100                 105                 110         


Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr 
        115                 120                 125             


Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp 
    130                 135                 140                 


Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu 
            180                 185                 190         


Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys 
        195                 200                 205             


Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215                 


<210>  13
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human-canine chimera

<400>  13
caggtgcagc tggtggaaag cggcggcggc gtggtgcagc cgggccgcag cctgcgcctg       60

agctgcaccg cgagcggctt tacctttagc aactatggca tgcattgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtggcggtg atttggtatg atggcagcaa caaacattat      180

ggcgatagcg tgaaaggccg ctttaccatt agcagcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgcggcgaa      300

cgcctgggca gctattttga ttattggggc cagggcaccc tggtgaccgt gagcagcgcg      360

agcaccaccg cgccgagcgt gtttccgctg gcgccgagct gcggcagcac cagcggcagc      420

accgtggcgc tggcgtgcct ggtgagcggc tattttccgg aaccggtgac cgtgagctgg      480

aacagcggca gcctgaccag cggcgtgcat acctttccga gcgtgctgca gagcagcggc      540

ctgtatagcc tgagcagcat ggtgaccgtg ccgagcagcc gctggccgag cgaaaccttt      600

acctgcaacg tggcgcatcc ggcgagcaaa accaaagtgg ataaaccggt gccgaaacgc      660

gaaaacggcc gcgtgccgcg cccgccggat tgcccgaaat gcccggcgcc ggaaatgctg      720

ggcggcccga gcgtgtttat ttttccgccg aaaccgaaag ataccctgct gattgcgcgc      780

accccggaag tgacctgcgt ggtggtggcg ctggatccgg aagatccgga agtgcagatt      840

agctggtttg tggatggcaa acagatgcag accgcgaaaa cccagccgcg cgaagaacag      900

tttgcgggca cctatcgcgt ggtgagcgtg ctgccgattg gccatcagga ttggctgaaa      960

ggcaaacagt ttacctgcaa agtgaacaac aaagcgctgc cgagcccgat tgaacgcacc     1020

attagcaaag cgcgcggcca ggcgcatcag ccgagcgtgt atgtgctgcc gccgagccgc     1080

gaagaactga gcaaaaacac cgtgagcctg acctgcctga ttaaagattt ttttccgccg     1140

gatattgatg tggaatggca gagcaacggc cagcaggaac cggaaagcaa atatcgcacc     1200

accccgccgc agctggatga agatggcagc tattttctgt atagcaaact gagcgtggat     1260

aaaagccgct ggcagcgcgg cgataccttt atttgcgcgg tgatgcatga agcgctgcat     1320

aaccattata cccaggaaag cctgagccat agcccgggca aa                        1362


<210>  14
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human-canine chimera

<400>  14

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys His Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Glu Arg Leu Gly Ser Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu 
    130                 135                 140                 


Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser 
            180                 185                 190         


Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala 
        195                 200                 205             


Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg 
    210                 215                 220                 


Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu Asp 
            260                 265                 270         


Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln 
        275                 280                 285             


Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys 
305                 310                 315                 320 


Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro 
                325                 330                 335     


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
            340                 345                 350         


Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val 
    370                 375                 380                 


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr 
385                 390                 395                 400 


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys 
            420                 425                 430         


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu 
        435                 440                 445             


Ser His Ser Pro Gly Lys 
    450                 


<210>  15
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human-canine chimera

<400>  15
gaaattgtgc tgacccagag cccgggcacc ctgagcctga gcccgggcga acgcgcgacc       60

ctgagctgcc gcaccagcgt gagcagcagc tatctggcgt ggtatcagca gaaaccgggc      120

caggcgccgc gcctgctgat ttatggcgcg agcagccgcg cgaccggcat tccggatcgc      180

tttagcggca gcggcagcgg caccgatttt accctgacca ttagccgcct ggaaccggaa      240

gattttgcgg tgtattattg ccagcagtat ggcattagcc cgtttacctt tggcggcggc      300

accaaagtgg aaattaaacg caacgatgcg cagccggcgg tgtatctgtt tcagccgagc      360

ccggatcagc tgcataccgg cagcgcgagc gtggtgtgcc tgctgaacag cttttatccg      420

aaagatatta acgtgaaatg gaaagtggat ggcgtgattc aggataccgg cattcaggaa      480

agcgtgaccg aacaggatag caaagatagc acctatagcc tgagcagcac cctgaccatg      540

agcagcaccg aatatctgag ccatgaactg tatagctgcg aaattaccca taaaagcctg      600

ccgagcaccc tgattaaaag ctttcagcgc agcgaatgcc agcgcgtgga t               651


<210>  16
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human-canine chimera

<400>  16

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Val Ser Ser Ser Tyr Leu 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ile Ser Pro Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Asn Asp Ala Gln Pro 
            100                 105                 110         


Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly Ser 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  17
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human-canine chimera

<400>  17
caggtgcagc tggtggaaag cggcggcggc gtggtggaac cgggccgcag cctgcgcctg       60

agctgcaccg cgagcggctt tacctttagc agctatggca tgcattgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtggcggtg atttggtatg atggcagcaa caaacattat      180

gcggatagcg cgaaaggccg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgcgcgggc      300

ctgctgggct attttgatta ttggggccag ggcaccctgg tgaccgtgag cagcgcgagc      360

accaccgcgc cgagcgtgtt tccgctggcg ccgagctgcg gcagcaccag cggcagcacc      420

gtggcgctgg cgtgcctggt gagcggctat tttccggaac cggtgaccgt gagctggaac      480

agcggcagcc tgaccagcgg cgtgcatacc tttccgagcg tgctgcagag cagcggcctg      540

tatagcctga gcagcatggt gaccgtgccg agcagccgct ggccgagcga aacctttacc      600

tgcaacgtgg cgcatccggc gagcaaaacc aaagtggata aaccggtgcc gaaacgcgaa      660

aacggccgcg tgccgcgccc gccggattgc ccgaaatgcc cggcgccgga aatgctgggc      720

ggcccgagcg tgtttatttt tccgccgaaa ccgaaagata ccctgctgat tgcgcgcacc      780

ccggaagtga cctgcgtggt ggtggcgctg gatccggaag atccggaagt gcagattagc      840

tggtttgtgg atggcaaaca gatgcagacc gcgaaaaccc agccgcgcga agaacagttt      900

gcgggcacct atcgcgtggt gagcgtgctg ccgattggcc atcaggattg gctgaaaggc      960

aaacagttta cctgcaaagt gaacaacaaa gcgctgccga gcccgattga acgcaccatt     1020

agcaaagcgc gcggccaggc gcatcagccg agcgtgtatg tgctgccgcc gagccgcgaa     1080

gaactgagca aaaacaccgt gagcctgacc tgcctgatta aagatttttt tccgccggat     1140

attgatgtgg aatggcagag caacggccag caggaaccgg aaagcaaata tcgcaccacc     1200

ccgccgcagc tggatgaaga tggcagctat tttctgtata gcaaactgag cgtggataaa     1260

agccgctggc agcgcggcga tacctttatt tgcgcggtga tgcatgaagc gctgcataac     1320

cattataccc aggaaagcct gagccatagc ccgggcaaa                            1359


<210>  18
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human-canine chimera

<400>  18

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Glu Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys His Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Leu Leu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala 
    130                 135                 140                 


Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser 
            180                 185                 190         


Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser 
        195                 200                 205             


Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val 
    210                 215                 220                 


Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu 
                245                 250                 255     


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu Asp Pro 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met 
        275                 280                 285             


Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly 
305                 310                 315                 320 


Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile 
                325                 330                 335     


Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val 
            340                 345                 350         


Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu 
    370                 375                 380                 


Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr 
385                 390                 395                 400 


Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser 
        435                 440                 445             


His Ser Pro Gly Lys 
    450             


<210>  19
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human-canine chimera

<400>  19
gaaattgtgc tgacccagag cccgggcacc ctgagcctga gcccgggcga acgcgcgacc       60

ctgagctgcc gcgcgagcca gagcgtgagc agctatctgg cgtggtatca gcagaaaccg      120

ggccaggcgc cgcgcccgct gatttatggc gtgagcagcc gcgcgaccgg cattccggat      180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagccg cctggaaccg      240

gaagattttg cggtgtatta ttgccagcag tatggcatta gcccgtttac ctttggcccg      300

ggcaccaaag tggatattaa acgcaacgat gcgcagccgg cggtgtatct gtttcagccg      360

agcccggatc agctgcatac cggcagcgcg agcgtggtgt gcctgctgaa cagcttttat      420

ccgaaagata ttaacgtgaa atggaaagtg gatggcgtga ttcaggatac cggcattcag      480

gaaagcgtga ccgaacagga tagcaaagat agcacctata gcctgagcag caccctgacc      540

atgagcagca ccgaatatct gagccatgaa ctgtatagct gcgaaattac ccataaaagc      600

ctgccgagca ccctgattaa aagctttcag cgcagcgaat gccagcgcgt ggat            654


<210>  20
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human-canine chimera

<400>  20

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile 
        35                  40                  45              


Tyr Gly Val Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ile Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr 
            180                 185                 190         


Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser 
        195                 200                 205             


Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215             


<210>  21
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human-canine chimera

<400>  21
caggtgcagc tggtggaaag cggcggcggc gtggtgcagc cgggccgcag cctgcgcctg       60

agctgcgcgg cgagcggctt tacctttagc agctatacca tgcattgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtgaccttt attagctatg atggcaacaa caaatattat      180

gcggatagcg tgaaaggccg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgcaccggc      300

tggctgggcc cgtttgatta ttggggccag ggcaccctgg tgaccgtgag cagcgcgagc      360

accaccgcgc cgagcgtgtt tccgctggcg ccgagctgcg gcagcaccag cggcagcacc      420

gtggcgctgg cgtgcctggt gagcggctat tttccggaac cggtgaccgt gagctggaac      480

agcggcagcc tgaccagcgg cgtgcatacc tttccgagcg tgctgcagag cagcggcctg      540

tatagcctga gcagcatggt gaccgtgccg agcagccgct ggccgagcga aacctttacc      600

tgcaacgtgg cgcatccggc gagcaaaacc aaagtggata aaccggtgcc gaaacgcgaa      660

aacggccgcg tgccgcgccc gccggattgc ccgaaatgcc cggcgccgga aatgctgggc      720

ggcccgagcg tgtttatttt tccgccgaaa ccgaaagata ccctgctgat tgcgcgcacc      780

ccggaagtga cctgcgtggt ggtggcgctg gatccggaag atccggaagt gcagattagc      840

tggtttgtgg atggcaaaca gatgcagacc gcgaaaaccc agccgcgcga agaacagttt      900

gcgggcacct atcgcgtggt gagcgtgctg ccgattggcc atcaggattg gctgaaaggc      960

aaacagttta cctgcaaagt gaacaacaaa gcgctgccga gcccgattga acgcaccatt     1020

agcaaagcgc gcggccaggc gcatcagccg agcgtgtatg tgctgccgcc gagccgcgaa     1080

gaactgagca aaaacaccgt gagcctgacc tgcctgatta aagatttttt tccgccggat     1140

attgatgtgg aatggcagag caacggccag caggaaccgg aaagcaaata tcgcaccacc     1200

ccgccgcagc tggatgaaga tggcagctat tttctgtata gcaaactgag cgtggataaa     1260

agccgctggc agcgcggcga tacctttatt tgcgcggtga tgcatgaagc gctgcataac     1320

cattataccc aggaaagcct gagccatagc ccgggcaaa                            1359


<210>  22
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hyman-canine chimera

<400>  22

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala 
    130                 135                 140                 


Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser 
            180                 185                 190         


Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser 
        195                 200                 205             


Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val 
    210                 215                 220                 


Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu 
                245                 250                 255     


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu Asp Pro 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met 
        275                 280                 285             


Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly 
305                 310                 315                 320 


Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile 
                325                 330                 335     


Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val 
            340                 345                 350         


Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu 
    370                 375                 380                 


Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr 
385                 390                 395                 400 


Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser 
        435                 440                 445             


His Ser Pro Gly Lys 
    450             


<210>  23
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human-canine chimera

<400>  23
gaaattgtgc tgacccagag cccgggcacc ctgagcctga gcccgggcga acgcgcgacc       60

ctgagctgcc gcgcgagcca gagcgtgggc agcagctatc tggcgtggta tcagcagaaa      120

ccgggccagg cgccgcgcct gctgatttat ggcgcgttta gccgcgcgac cggcattccg      180

gatcgcttta gcggcagcgg cagcggcacc gattttaccc tgaccattag ccgcctggaa      240

ccggaagatt ttgcggtgta ttattgccag cagtatggca gcagcccgtg gacctttggc      300

cagggcacca aagtggaaat taaacgcaac gatgcgcagc cggcggtgta tctgtttcag      360

ccgagcccgg atcagctgca taccggcagc gcgagcgtgg tgtgcctgct gaacagcttt      420

tatccgaaag atattaacgt gaaatggaaa gtggatggcg tgattcagga taccggcatt      480

caggaaagcg tgaccgaaca ggatagcaaa gatagcacct atagcctgag cagcaccctg      540

accatgagca gcaccgaata tctgagccat gaactgtata gctgcgaaat tacccataaa      600

agcctgccga gcaccctgat taaaagcttt cagcgcagcg aatgccagcg cgtggat         657


<210>  24
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human-canine chimera

<400>  24

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Asn Asp Ala 
            100                 105                 110         


Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr 
        115                 120                 125             


Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp 
    130                 135                 140                 


Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu 
            180                 185                 190         


Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys 
        195                 200                 205             


Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215                 


<210>  25
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human-canine chimera

<400>  25
caggtgcagc tggtggaaag cggcggcggc gtggtgcagc cgggccgcag cctgcgcctg       60

agctgcgcgg cgagcggctt tacctttagc agctatggca tgcattgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtggcggtg atttggtatg atggcagcaa caaatattat      180

gcggatagcg tgaaaggccg ctttaccatt agccgcgata acagcaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt tttattgcgc gcgcgcgccg      300

aactatattg gcgcgtttga tgtgtggggc cagggcacca tggtgaccgt gagcagcgcg      360

agcaccaccg cgccgagcgt gtttccgctg gcgccgagct gcggcagcac cagcggcagc      420

accgtggcgc tggcgtgcct ggtgagcggc tattttccgg aaccggtgac cgtgagctgg      480

aacagcggca gcctgaccag cggcgtgcat acctttccga gcgtgctgca gagcagcggc      540

ctgtatagcc tgagcagcat ggtgaccgtg ccgagcagcc gctggccgag cgaaaccttt      600

acctgcaacg tggcgcatcc ggcgagcaaa accaaagtgg ataaaccggt gccgaaacgc      660

gaaaacggcc gcgtgccgcg cccgccggat tgcccgaaat gcccggcgcc ggaaatgctg      720

ggcggcccga gcgtgtttat ttttccgccg aaaccgaaag ataccctgct gattgcgcgc      780

accccggaag tgacctgcgt ggtggtggcg ctggatccgg aagatccgga agtgcagatt      840

agctggtttg tggatggcaa acagatgcag accgcgaaaa cccagccgcg cgaagaacag      900

tttgcgggca cctatcgcgt ggtgagcgtg ctgccgattg gccatcagga ttggctgaaa      960

ggcaaacagt ttacctgcaa agtgaacaac aaagcgctgc cgagcccgat tgaacgcacc     1020

attagcaaag cgcgcggcca ggcgcatcag ccgagcgtgt atgtgctgcc gccgagccgc     1080

gaagaactga gcaaaaacac cgtgagcctg acctgcctga ttaaagattt ttttccgccg     1140

gatattgatg tggaatggca gagcaacggc cagcaggaac cggaaagcaa atatcgcacc     1200

accccgccgc agctggatga agatggcagc tattttctgt atagcaaact gagcgtggat     1260

aaaagccgct ggcagcgcgg cgataccttt atttgcgcgg tgatgcatga agcgctgcat     1320

aaccattata cccaggaaag cctgagccat agcccgggca aa                        1362


<210>  26
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human-canine chimera

<400>  26

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Phe Tyr Cys 
                85                  90                  95      


Ala Arg Ala Pro Asn Tyr Ile Gly Ala Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu 
    130                 135                 140                 


Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser 
            180                 185                 190         


Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala 
        195                 200                 205             


Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg 
    210                 215                 220                 


Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu Asp 
            260                 265                 270         


Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln 
        275                 280                 285             


Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys 
305                 310                 315                 320 


Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro 
                325                 330                 335     


Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser 
            340                 345                 350         


Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val 
    370                 375                 380                 


Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr 
385                 390                 395                 400 


Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys 
            420                 425                 430         


Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu 
        435                 440                 445             


Ser His Ser Pro Gly Lys 
    450                 


<210>  27
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human-canine chimera

<400>  27
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

attacctgcc gcgcgagcca gggcattagc agctggctgg cgtggtatca gcagaaaccg      120

gaaaaagcgc cgaaaagcct gatttatgcg gcgagcagcc tgcagagcgg cgtgccgagc      180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg      240

gaagattttg cgacctatta ttgccagcag tataacagct atccgccgac ctttggccag      300

ggcaccaaag tggaaattaa acgcaacgat gcgcagccgg cggtgtatct gtttcagccg      360

agcccggatc agctgcatac cggcagcgcg agcgtggtgt gcctgctgaa cagcttttat      420

ccgaaagata ttaacgtgaa atggaaagtg gatggcgtga ttcaggatac cggcattcag      480

gaaagcgtga ccgaacagga tagcaaagat agcacctata gcctgagcag caccctgacc      540

atgagcagca ccgaatatct gagccatgaa ctgtatagct gcgaaattac ccataaaagc      600

ctgccgagca ccctgattaa aagctttcag cgcagcgaat gccagcgcgt ggat            654


<210>  28
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human-canine chimera

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr 
            180                 185                 190         


Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser 
        195                 200                 205             


Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215             


<210>  29
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  murine-canine chimera

<400>  29
gaagtgaaac tggtgaacag cggcggcggc ctggtgcagc cgggcaacag cctgcgcctg       60

agctgcgcga ccagcggctt tacctttacc gatttttata tgagctgggt gcgccagccg      120

ccgggcaaag cgctggaatg gctgggcttt gtgcgcaacc gcgcgaacgg ctataccacc      180

gaatatagcg tgagcgtgaa aggccgcttt attattagcc gcgataactt tcagagcacc      240

ctgtttctgc agatgaacac cctgcgcgcg gaagatagcg gcacctatta ttgcgtgcgc      300

ggcccgggcg ataccgcgga ttataccatg gattattggg gccagggcac cagcgtgacc      360

gtgagcagcg cgagcaccac cgcgccgagc gtgtttccgc tggcgccgag ctgcggcagc      420

accagcggca gcaccgtggc gctggcgtgc ctggtgagcg gctattttcc ggaaccggtg      480

accgtgagct ggaacagcgg cagcctgacc agcggcgtgc atacctttcc gagcgtgctg      540

cagagcagcg gcctgtatag cctgagcagc atggtgaccg tgccgagcag ccgctggccg      600

agcgaaacct ttacctgcaa cgtggcgcat ccggcgagca aaaccaaagt ggataaaccg      660

gtgccgaaac gcgaaaacgg ccgcgtgccg cgcccgccgg attgcccgaa atgcccggcg      720

ccggaaatgc tgggcggccc gagcgtgttt atttttccgc cgaaaccgaa agataccctg      780

ctgattgcgc gcaccccgga agtgacctgc gtggtggtgg cgctggatcc ggaagatccg      840

gaagtgcaga ttagctggtt tgtggatggc aaacagatgc agaccgcgaa aacccagccg      900

cgcgaagaac agtttgcggg cacctatcgc gtggtgagcg tgctgccgat tggccatcag      960

gattggctga aaggcaaaca gtttacctgc aaagtgaaca acaaagcgct gccgagcccg     1020

attgaacgca ccattagcaa agcgcgcggc caggcgcatc agccgagcgt gtatgtgctg     1080

ccgccgagcc gcgaagaact gagcaaaaac accgtgagcc tgacctgcct gattaaagat     1140

ttttttccgc cggatattga tgtggaatgg cagagcaacg gccagcagga accggaaagc     1200

aaatatcgca ccaccccgcc gcagctggat gaagatggca gctattttct gtatagcaaa     1260

ctgagcgtgg ataaaagccg ctggcagcgc ggcgatacct ttatttgcgc ggtgatgcat     1320

gaagcgctgc ataaccatta tacccaggaa agcctgagcc atagcccggg caaa           1374


<210>  30
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine-canine chimera

<400>  30

Glu Val Lys Leu Val Asn Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Thr Asp Phe 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Phe Val Arg Asn Arg Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Val 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Phe Gln Ser Thr 
65                  70                  75                  80  


Leu Phe Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Ser Gly Thr Tyr 
                85                  90                  95      


Tyr Cys Val Arg Gly Pro Gly Asp Thr Ala Asp Tyr Thr Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Ala 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser 
    130                 135                 140                 


Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val 
            180                 185                 190         


Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val 
        195                 200                 205             


Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg 
    210                 215                 220                 


Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Ala Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val 
        275                 280                 285             


Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln 
    290                 295                 300                 


Phe Ala Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln 
305                 310                 315                 320 


Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala 
                325                 330                 335     


Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala 
            340                 345                 350         


His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser 
        355                 360                 365             


Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro 
    370                 375                 380                 


Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser 
385                 390                 395                 400 


Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe 
                405                 410                 415     


Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp 
            420                 425                 430         


Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr 
        435                 440                 445             


Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    450                 455             


<210>  31
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  murine-canine chimera

<400>  31
caggcggtgg tgacccagga aagcgcgttt accaccagcc cgggcggcac cgtgattctg       60

acctgccgca gcagcaccgg cgcggtgacc accaacaact atgcgaactg ggtgcaggaa      120

aaaccggatc atctgtttac cggcctgatt ggcggcacca gcaaccgcgc gccgggcgtg      180

ccggtgcgct ttagcggcag cctgattggc gataaagcgg cgctgaccat taccggcgcg      240

cagaccgaag atgatggcat gtatttttgc gcgctgtggt ataccaccca ttttgtgttt      300

ggcggcggca ccaaagtgac cgtgctgggc cagccgaaag cgagcccgag cgtgaccctg      360

tttccgccga gcagcgaaga actgggcgcg aacaaagcga ccctggtgtg cctgattagc      420

gatttttatc cgagcggcgt gaccgtggcg tggaaagcgg atggcagccc gattacccag      480

ggcgtggaaa ccaccaaacc gagcaaacag agcaacaaca aatatgcggc gagcagctat      540

ctgagcctga ccccggataa atggaaaagc catagcagct ttagctgcct ggtgacccat      600

gaaggcagca ccgtggaaaa aaaagtggcg ccggcggaat gcagc                      645


<210>  32
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  murine-canine chimera

<400>  32

Gln Ala Val Val Thr Gln Glu Ser Ala Phe Thr Thr Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Ile Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Asn 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Ser Asn Arg Ala Pro Gly Val Pro Val Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Asp Gly Met Tyr Phe Cys Ala Leu Trp Tyr Thr Thr 
                85                  90                  95      


His Phe Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gly Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Ser Gly Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Ile Thr Gln 
145                 150                 155                 160 


Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Asp Lys Trp Lys Ser His Ser 
            180                 185                 190         


Ser Phe Ser Cys Leu Val Thr His Glu Gly Ser Thr Val Glu Lys Lys 
        195                 200                 205             


Val Ala Pro Ala Glu Cys Ser 
    210                 215 


<210>  33
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  33
gaagtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tacctttacc gattataaca tggattgggt gcgccaggcg      120

ccgggcgcgg gcctggattg gatgggcaac attaacccga acagcgaaag caccagctat      180

aaccagaaat ttaaaggccg cgtgaccctg accgcggata ccagcaccag caccgcgtat      240

atggaactga gcagcctgcg cgcgggcgat attgcggtgt attattgcac ccgcgatggc      300

aaccgctatg atgcgtggtt tgcgtattgg ggccagggca ccctggtgac cgtgagcagc      360

gcgagcacca ccgcgccgag cgtgtttccg ctggcgccga gctgcggcag caccagcggc      420

agcaccgtgg cgctggcgtg cctggtgagc ggctattttc cggaaccggt gaccgtgagc      480

tggaacagcg gcagcctgac cagcggcgtg catacctttc cgagcgtgct gcagagcagc      540

ggcctgtata gcctgagcag catggtgacc gtgccgagca gccgctggcc gagcgaaacc      600

tttacctgca acgtggcgca tccggcgagc aaaaccaaag tggataaacc ggtgccgaaa      660

cgcgaaaacg gccgcgtgcc gcgcccgccg gattgcccga aatgcccggc gccggaaatg      720

ctgggcggcc cgagcgtgtt tatttttccg ccgaaaccga aagataccct gctgattgcg      780

cgcaccccgg aagtgacctg cgtggtggtg gatctggatc cggaagatcc ggaagtgcag      840

attagctggt ttgtggatgg caaacagatg cagaccgcga aaacccagcc gcgcgaagaa      900

cagtttaacg gcacctatcg cgtggtgagc gtgctgccga ttggccatca ggattggctg      960

aaaggcaaac agtttacctg caaagtgaac aacaaagcgc tgccgagccc gattgaacgc     1020

accattagca aagcgcgcgg ccaggcgcat cagccgagcg tgtatgtgct gccgccgagc     1080

cgcgaagaac tgagcaaaaa caccgtgagc ctgacctgcc tgattaaaga tttttttccg     1140

ccggatattg atgtggaatg gcagagcaac ggccagcagg aaccggaaag caaatatcgc     1200

accaccccgc cgcagctgga tgaagatggc agctattttc tgtatagcaa actgagcgtg     1260

gataaaagcc gctggcagcg cggcgatacc tttatttgcg cggtgatgca tgaagcgctg     1320

cataaccatt atacccagga aagcctgagc catagcccgg gcaaa                     1365


<210>  34
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  34

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Ser Glu Ser Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Gly Asn Arg Tyr Asp Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala 
    130                 135                 140                 


Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly 
    210                 215                 220                 


Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu 
            260                 265                 270         


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        275                 280                 285             


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
305                 310                 315                 320 


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            340                 345                 350         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    370                 375                 380                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
385                 390                 395                 400 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            420                 425                 430         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210>  35
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  35
gaagtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tacctttacc gattataaca tggattgggt gcgccaggcg      120

ccgggcgcga gcctggattg gattggcaac attaacccga acagcgaaag caccagctat      180

aaccagaaat ttaaaggcaa agcgaccctg accgtggata aaagcaccag caccgcgtat      240

atggaactga gcagcctgcg cgcgggcgat attgcggtgt attattgcac ccgcgatggc      300

aaccgctatg atgcgtggtt tgcgtattgg ggccagggca ccctggtgac cgtgagcagc      360

gcgagcacca ccgcgccgag cgtgtttccg ctggcgccga gctgcggcag caccagcggc      420

agcaccgtgg cgctggcgtg cctggtgagc ggctattttc cggaaccggt gaccgtgagc      480

tggaacagcg gcagcctgac cagcggcgtg catacctttc cgagcgtgct gcagagcagc      540

ggcctgtata gcctgagcag catggtgacc gtgccgagca gccgctggcc gagcgaaacc      600

tttacctgca acgtggcgca tccggcgagc aaaaccaaag tggataaacc ggtgccgaaa      660

cgcgaaaacg gccgcgtgcc gcgcccgccg gattgcccga aatgcccggc gccggaaatg      720

ctgggcggcc cgagcgtgtt tatttttccg ccgaaaccga aagataccct gctgattgcg      780

cgcaccccgg aagtgacctg cgtggtggtg gatctggatc cggaagatcc ggaagtgcag      840

attagctggt ttgtggatgg caaacagatg cagaccgcga aaacccagcc gcgcgaagaa      900

cagtttaacg gcacctatcg cgtggtgagc gtgctgccga ttggccatca ggattggctg      960

aaaggcaaac agtttacctg caaagtgaac aacaaagcgc tgccgagccc gattgaacgc     1020

accattagca aagcgcgcgg ccaggcgcat cagccgagcg tgtatgtgct gccgccgagc     1080

cgcgaagaac tgagcaaaaa caccgtgagc ctgacctgcc tgattaaaga tttttttccg     1140

ccggatattg atgtggaatg gcagagcaac ggccagcagg aaccggaaag caaatatcgc     1200

accaccccgc cgcagctgga tgaagatggc agctattttc tgtatagcaa actgagcgtg     1260

gataaaagcc gctggcagcg cggcgatacc tttatttgcg cggtgatgca tgaagcgctg     1320

cataaccatt atacccagga aagcctgagc catagcccgg gcaaa                     1365


<210>  36
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  36

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Arg Gln Ala Pro Gly Ala Ser Leu Asp Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Ser Glu Ser Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Gly Asn Arg Tyr Asp Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala 
    130                 135                 140                 


Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly 
    210                 215                 220                 


Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu 
            260                 265                 270         


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        275                 280                 285             


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
305                 310                 315                 320 


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            340                 345                 350         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    370                 375                 380                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
385                 390                 395                 400 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            420                 425                 430         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210>  37
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  37
gaagtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tacctttacc gattataaca tggattgggt gcgccaggcg      120

catggcgcga gcctggattg gattggcaac attaacccga acagcgaaag caccagctat      180

aaccagaaat ttaaaggcaa agcgaccctg accgtggata aaagcaccag caccgcgtat      240

atggaactga gcagcctgcg cgcgggcgat attgcggtgt attattgcac ccgcgatggc      300

aaccgctatg atgcgtggtt tgcgtattgg ggccagggca ccctggtgac cgtgagcagc      360

gcgagcacca ccgcgccgag cgtgtttccg ctggcgccga gctgcggcag caccagcggc      420

agcaccgtgg cgctggcgtg cctggtgagc ggctattttc cggaaccggt gaccgtgagc      480

tggaacagcg gcagcctgac cagcggcgtg catacctttc cgagcgtgct gcagagcagc      540

ggcctgtata gcctgagcag catggtgacc gtgccgagca gccgctggcc gagcgaaacc      600

tttacctgca acgtggcgca tccggcgagc aaaaccaaag tggataaacc ggtgccgaaa      660

cgcgaaaacg gccgcgtgcc gcgcccgccg gattgcccga aatgcccggc gccggaaatg      720

ctgggcggcc cgagcgtgtt tatttttccg ccgaaaccga aagataccct gctgattgcg      780

cgcaccccgg aagtgacctg cgtggtggtg gatctggatc cggaagatcc ggaagtgcag      840

attagctggt ttgtggatgg caaacagatg cagaccgcga aaacccagcc gcgcgaagaa      900

cagtttaacg gcacctatcg cgtggtgagc gtgctgccga ttggccatca ggattggctg      960

aaaggcaaac agtttacctg caaagtgaac aacaaagcgc tgccgagccc gattgaacgc     1020

accattagca aagcgcgcgg ccaggcgcat cagccgagcg tgtatgtgct gccgccgagc     1080

cgcgaagaac tgagcaaaaa caccgtgagc ctgacctgcc tgattaaaga tttttttccg     1140

ccggatattg atgtggaatg gcagagcaac ggccagcagg aaccggaaag caaatatcgc     1200

accaccccgc cgcagctgga tgaagatggc agctattttc tgtatagcaa actgagcgtg     1260

gataaaagcc gctggcagcg cggcgatacc tttatttgcg cggtgatgca tgaagcgctg     1320

cataaccatt atacccagga aagcctgagc catagcccgg gcaaa                     1365


<210>  38
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  38

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Arg Gln Ala His Gly Ala Ser Leu Asp Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Ser Glu Ser Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Gly Asn Arg Tyr Asp Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala 
    130                 135                 140                 


Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly 
    210                 215                 220                 


Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu 
            260                 265                 270         


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        275                 280                 285             


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
305                 310                 315                 320 


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            340                 345                 350         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    370                 375                 380                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
385                 390                 395                 400 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            420                 425                 430         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210>  39
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  39
gaagtgcagc tgcagcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tacctttacc gattataaca tggattgggt gcgccaggcg      120

ccgggcgcga gcctggattg gattggcaac attaacccga acagcgaaag caccagctat      180

aaccagaaat ttaaaggcaa agcgaccctg accgtggata aaagcaccag caccgcgtat      240

atggaactgc gcagcctgac cgcgggcgat attgcggtgt attattgcac ccgcgatggc      300

aaccgctatg atgcgtggtt tgcgtattgg ggccagggca ccctggtgac cgtgagcagc      360

gcgagcacca ccgcgccgag cgtgtttccg ctggcgccga gctgcggcag caccagcggc      420

agcaccgtgg cgctggcgtg cctggtgagc ggctattttc cggaaccggt gaccgtgagc      480

tggaacagcg gcagcctgac cagcggcgtg catacctttc cgagcgtgct gcagagcagc      540

ggcctgtata gcctgagcag catggtgacc gtgccgagca gccgctggcc gagcgaaacc      600

tttacctgca acgtggcgca tccggcgagc aaaaccaaag tggataaacc ggtgccgaaa      660

cgcgaaaacg gccgcgtgcc gcgcccgccg gattgcccga aatgcccggc gccggaaatg      720

ctgggcggcc cgagcgtgtt tatttttccg ccgaaaccga aagataccct gctgattgcg      780

cgcaccccgg aagtgacctg cgtggtggtg gatctggatc cggaagatcc ggaagtgcag      840

attagctggt ttgtggatgg caaacagatg cagaccgcga aaacccagcc gcgcgaagaa      900

cagtttaacg gcacctatcg cgtggtgagc gtgctgccga ttggccatca ggattggctg      960

aaaggcaaac agtttacctg caaagtgaac aacaaagcgc tgccgagccc gattgaacgc     1020

accattagca aagcgcgcgg ccaggcgcat cagccgagcg tgtatgtgct gccgccgagc     1080

cgcgaagaac tgagcaaaaa caccgtgagc ctgacctgcc tgattaaaga tttttttccg     1140

ccggatattg atgtggaatg gcagagcaac ggccagcagg aaccggaaag caaatatcgc     1200

accaccccgc cgcagctgga tgaagatggc agctattttc tgtatagcaa actgagcgtg     1260

gataaaagcc gctggcagcg cggcgatacc tttatttgcg cggtgatgca tgaagcgctg     1320

cataaccatt atacccagga aagcctgagc catagcccgg gcaaa                     1365


<210>  40
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  40

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Arg Gln Ala Pro Gly Ala Ser Leu Asp Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Ser Glu Ser Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Gly Asn Arg Tyr Asp Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala 
    130                 135                 140                 


Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly 
    210                 215                 220                 


Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu 
            260                 265                 270         


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        275                 280                 285             


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
305                 310                 315                 320 


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            340                 345                 350         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    370                 375                 380                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
385                 390                 395                 400 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            420                 425                 430         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210>  41
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  41
gatattgtga tgacccagac cccgctgagc ctgagcgtga gcccgggcga accggcgagc       60

attagctgca gcgcgagcag cagcgtgacc tatatgcatt ggtttcgcca taaaccgggc      120

cagagcccgc agagcctgat ttatagcacc agcattctgg cgagcggcgt gccggatcgc      180

tttagcggca gcggcagcgg caccgatttt accctgaaaa ttagccgcgt ggaagcggat      240

gatgcgggcg tgtattattg ccagcagcgc accagctatc cgctgacctt tggcaccggc      300

accaaactgg aactgaaacg caacgatgcg cagccggcgg tgtatctgtt tcagccgagc      360

ccggatcagc tgcataccgg cagcgcgagc gtggtgtgcc tgctgaacag cttttatccg      420

aaagatatta acgtgaaatg gaaagtggat ggcgtgattc aggataccgg cattcaggaa      480

agcgtgaccg aacaggatag caaagatagc acctatagcc tgagcagcac cctgaccatg      540

agcagcaccg aatatctgag ccatgaactg tatagctgcg aaattaccca taaaagcctg      600

ccgagcaccc tgattaaaag ctttcagcgc agcgaatgcc agcgcgtgga t               651


<210>  42
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  42

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 
            20                  25                  30          


His Trp Phe Arg His Lys Pro Gly Gln Ser Pro Gln Ser Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Ile Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Asp 
65                  70                  75                  80  


Asp Ala Gly Val Tyr Tyr Cys Gln Gln Arg Thr Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Thr Gly Thr Lys Leu Glu Leu Lys Arg Asn Asp Ala Gln Pro 
            100                 105                 110         


Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly Ser 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  43
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  43
cagattgtga tgacccagac cccgctgagc ctgagcgtga gcccgggcga accggcgagc       60

attagctgca gcgcgagcag cagcgtgacc tatatgcatt ggtttcagca gaaaccgggc      120

cagagcccgc agagcctgat ttatagcacc agcattctgg cgagcggcgt gccggatcgc      180

tttagcggca gcggcagcgg caccgatttt accctgaaaa ttagccgcgt ggaagcggat      240

gatgcgggcg tgtattattg ccagcagcgc accagctatc cgctgacctt tggcaccggc      300

accaaactgg aactgaaacg caacgatgcg cagccggcgg tgtatctgtt tcagccgagc      360

ccggatcagc tgcataccgg cagcgcgagc gtggtgtgcc tgctgaacag cttttatccg      420

aaagatatta acgtgaaatg gaaagtggat ggcgtgattc aggataccgg cattcaggaa      480

agcgtgaccg aacaggatag caaagatagc acctatagcc tgagcagcac cctgaccatg      540

agcagcaccg aatatctgag ccatgaactg tatagctgcg aaattaccca taaaagcctg      600

ccgagcaccc tgattaaaag ctttcagcgc agcgaatgcc agcgcgtgga t               651


<210>  44
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  44

Gln Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Gln Ser Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Ile Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Asp 
65                  70                  75                  80  


Asp Ala Gly Val Tyr Tyr Cys Gln Gln Arg Thr Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Thr Gly Thr Lys Leu Glu Leu Lys Arg Asn Asp Ala Gln Pro 
            100                 105                 110         


Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly Ser 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  45
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  45
cagattgtgc tgacccagac cccgctgagc ctgagcgtga gcccgggcga accggcgagc       60

attagctgca gcgcgagcag cagcgtgacc tatatgcatt ggtttcagca gaaaccgggc      120

cagagcccga aaagctggat ttatagcacc agcattctgg cgagcggcgt gccggatcgc      180

tttagcggca gcggcagcgg caccgatttt accctgaaaa ttagccgcgt ggaagcggat      240

gatgcgggcg tgtattattg ccagcagcgc accagctatc cgctgacctt tggcaccggc      300

accaaactgg aactgaaacg caacgatgcg cagccggcgg tgtatctgtt tcagccgagc      360

ccggatcagc tgcataccgg cagcgcgagc gtggtgtgcc tgctgaacag cttttatccg      420

aaagatatta acgtgaaatg gaaagtggat ggcgtgattc aggataccgg cattcaggaa      480

agcgtgaccg aacaggatag caaagatagc acctatagcc tgagcagcac cctgaccatg      540

agcagcaccg aatatctgag ccatgaactg tatagctgcg aaattaccca taaaagcctg      600

ccgagcaccc tgattaaaag ctttcagcgc agcgaatgcc agcgcgtgga t               651


<210>  46
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  46

Gln Ile Val Leu Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro Lys Ser Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Ile Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Asp 
65                  70                  75                  80  


Asp Ala Gly Val Tyr Tyr Cys Gln Gln Arg Thr Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Thr Gly Thr Lys Leu Glu Leu Lys Arg Asn Asp Ala Gln Pro 
            100                 105                 110         


Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly Ser 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr Ser 
            180                 185                 190         


Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser Phe 
        195                 200                 205             


Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215         


<210>  47
<211>  15
<212>  DNA
<213>  Mus musculus

<400>  47
gattataaca tggat                                                        15


<210>  48
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  48

Asp Tyr Asn Met Asp 
1               5   


<210>  49
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  49
aacattaacc cgaacagcga aagcaccagc tataaccaga aatttaaagg c                51


<210>  50
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  50

Asn Ile Asn Pro Asn Ser Glu Ser Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  51
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  51
gatggcaacc gctatgatgc gtggtttgcg tat                                    33


<210>  52
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  52

Asp Gly Asn Arg Tyr Asp Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  53
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  53
agcgcgagca gcagcgtgac ctatatgcat                                        30


<210>  54
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  54

Ser Ala Ser Ser Ser Val Thr Tyr Met His 
1               5                   10  


<210>  55
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  55
agcaccagca ttctggcgag c                                                 21


<210>  56
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  56

Ser Thr Ser Ile Leu Ala Ser 
1               5           


<210>  57
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  57
cagcagcgca ccagctatcc gctgacc                                           27


<210>  58
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  58

Gln Gln Arg Thr Ser Tyr Pro Leu Thr 
1               5                   


<210>  59
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized murine antibody

<400>  59
gaagtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tacctttacc gattataaca tggattgggt gcgccaggcg      120

ccgggcgcgg gcctggattg gatgggcaac attaacccga acagcgaaag caccagctat      180

aaccagaaat ttaaaggccg cgtgaccctg accgcggata ccagcaccag caccgcgtat      240

atggaactga gcagcctgcg cgcgggcgat attgcggtgt attattgcac ccgcgatggc      300

aaccgctatg atgcgtggtt tgcgtattgg ggccagggca ccctggtgac cgtgagcagc      360

gcgagcacca ccgcgccgag cgtgtttccg ctggcgccga gctgcggcag caccagcggc      420

agcaccgtgg cgctggcgtg cctggtgagc ggctattttc cggaaccggt gaccgtgagc      480

tggaacagcg gcagcctgac cagcggcgtg catacctttc cgagcgtgct gcagagcagc      540

ggcctgtata gcctgagcag catggtgacc gtgccgagca gccgctggcc gagcgaaacc      600

tttacctgca acgtggcgca tccggcgagc aaaaccaaag tggataaacc ggtgccgaaa      660

cgcgaaaacg gccgcgtgcc gcgcccgccg gattgcccga aatgcccggc gccggaaatg      720

ctgggcggcc cgagcgtgtt tatttttccg ccgaaaccga aagataccct gctgattgcg      780

cgcaccccgg aagtgacctg cgtggtggtg gcgctggatc cggaagatcc ggaagtgcag      840

attagctggt ttgtggatgg caaacagatg cagaccgcga aaacccagcc gcgcgaagaa      900

cagtttgccg gcacctatcg cgtggtgagc gtgctgccga ttggccatca ggattggctg      960

aaaggcaaac agtttacctg caaagtgaac aacaaagcgc tgccgagccc gattgaacgc     1020

accattagca aagcgcgcgg ccaggcgcat cagccgagcg tgtatgtgct gccgccgagc     1080

cgcgaagaac tgagcaaaaa caccgtgagc ctgacctgcc tgattaaaga tttttttccg     1140

ccggatattg atgtggaatg gcagagcaac ggccagcagg aaccggaaag caaatatcgc     1200

accaccccgc cgcagctgga tgaagatggc agctattttc tgtatagcaa actgagcgtg     1260

gataaaagcc gctggcagcg cggcgatacc tttatttgcg cggtgatgca tgaagcgctg     1320

cataaccatt atacccagga aagcctgagc catagcccgg gcaaa                     1365


<210>  60
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  60

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Ser Glu Ser Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Gly Asn Arg Tyr Asp Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala 
    130                 135                 140                 


Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly 
    210                 215                 220                 


Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu 
            260                 265                 270         


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        275                 280                 285             


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
305                 310                 315                 320 


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            340                 345                 350         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    370                 375                 380                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
385                 390                 395                 400 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            420                 425                 430         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210>  61
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  61
gaagtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tacctttacc gattataaca tggattgggt gcgccaggcg      120

ccgggcgcga gcctggattg gattggcaac attaacccga acagcgaaag caccagctat      180

aaccagaaat ttaaaggcaa agcgaccctg accgtggata aaagcaccag caccgcgtat      240

atggaactga gcagcctgcg cgcgggcgat attgcggtgt attattgcac ccgcgatggc      300

aaccgctatg atgcgtggtt tgcgtattgg ggccagggca ccctggtgac cgtgagcagc      360

gcgagcacca ccgcgccgag cgtgtttccg ctggcgccga gctgcggcag caccagcggc      420

agcaccgtgg cgctggcgtg cctggtgagc ggctattttc cggaaccggt gaccgtgagc      480

tggaacagcg gcagcctgac cagcggcgtg catacctttc cgagcgtgct gcagagcagc      540

ggcctgtata gcctgagcag catggtgacc gtgccgagca gccgctggcc gagcgaaacc      600

tttacctgca acgtggcgca tccggcgagc aaaaccaaag tggataaacc ggtgccgaaa      660

cgcgaaaacg gccgcgtgcc gcgcccgccg gattgcccga aatgcccggc gccggaaatg      720

ctgggcggcc cgagcgtgtt tatttttccg ccgaaaccga aagataccct gctgattgcg      780

cgcaccccgg aagtgacctg cgtggtggtg gcgctggatc cggaagatcc ggaagtgcag      840

attagctggt ttgtggatgg caaacagatg cagaccgcga aaacccagcc gcgcgaagaa      900

cagtttgccg gcacctatcg cgtggtgagc gtgctgccga ttggccatca ggattggctg      960

aaaggcaaac agtttacctg caaagtgaac aacaaagcgc tgccgagccc gattgaacgc     1020

accattagca aagcgcgcgg ccaggcgcat cagccgagcg tgtatgtgct gccgccgagc     1080

cgcgaagaac tgagcaaaaa caccgtgagc ctgacctgcc tgattaaaga tttttttccg     1140

ccggatattg atgtggaatg gcagagcaac ggccagcagg aaccggaaag caaatatcgc     1200

accaccccgc cgcagctgga tgaagatggc agctattttc tgtatagcaa actgagcgtg     1260

gataaaagcc gctggcagcg cggcgatacc tttatttgcg cggtgatgca tgaagcgctg     1320

cataaccatt atacccagga aagcctgagc catagcccgg gcaaa                     1365


<210>  62
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  62

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Arg Gln Ala Pro Gly Ala Ser Leu Asp Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Ser Glu Ser Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Gly Asn Arg Tyr Asp Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala 
    130                 135                 140                 


Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly 
    210                 215                 220                 


Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu 
            260                 265                 270         


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        275                 280                 285             


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
305                 310                 315                 320 


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            340                 345                 350         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    370                 375                 380                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
385                 390                 395                 400 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            420                 425                 430         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210>  63
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  63
gaagtgcagc tggtgcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tacctttacc gattataaca tggattgggt gcgccaggcg      120

catggcgcga gcctggattg gattggcaac attaacccga acagcgaaag caccagctat      180

aaccagaaat ttaaaggcaa agcgaccctg accgtggata aaagcaccag caccgcgtat      240

atggaactga gcagcctgcg cgcgggcgat attgcggtgt attattgcac ccgcgatggc      300

aaccgctatg atgcgtggtt tgcgtattgg ggccagggca ccctggtgac cgtgagcagc      360

gcgagcacca ccgcgccgag cgtgtttccg ctggcgccga gctgcggcag caccagcggc      420

agcaccgtgg cgctggcgtg cctggtgagc ggctattttc cggaaccggt gaccgtgagc      480

tggaacagcg gcagcctgac cagcggcgtg catacctttc cgagcgtgct gcagagcagc      540

ggcctgtata gcctgagcag catggtgacc gtgccgagca gccgctggcc gagcgaaacc      600

tttacctgca acgtggcgca tccggcgagc aaaaccaaag tggataaacc ggtgccgaaa      660

cgcgaaaacg gccgcgtgcc gcgcccgccg gattgcccga aatgcccggc gccggaaatg      720

ctgggcggcc cgagcgtgtt tatttttccg ccgaaaccga aagataccct gctgattgcg      780

cgcaccccgg aagtgacctg cgtggtggtg gcgctggatc cggaagatcc ggaagtgcag      840

attagctggt ttgtggatgg caaacagatg cagaccgcga aaacccagcc gcgcgaagaa      900

cagtttgccg gcacctatcg cgtggtgagc gtgctgccga ttggccatca ggattggctg      960

aaaggcaaac agtttacctg caaagtgaac aacaaagcgc tgccgagccc gattgaacgc     1020

accattagca aagcgcgcgg ccaggcgcat cagccgagcg tgtatgtgct gccgccgagc     1080

cgcgaagaac tgagcaaaaa caccgtgagc ctgacctgcc tgattaaaga tttttttccg     1140

ccggatattg atgtggaatg gcagagcaac ggccagcagg aaccggaaag caaatatcgc     1200

accaccccgc cgcagctgga tgaagatggc agctattttc tgtatagcaa actgagcgtg     1260

gataaaagcc gctggcagcg cggcgatacc tttatttgcg cggtgatgca tgaagcgctg     1320

cataaccatt atacccagga aagcctgagc catagcccgg gcaaa                     1365


<210>  64
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  64

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Arg Gln Ala His Gly Ala Ser Leu Asp Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Ser Glu Ser Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Gly Asn Arg Tyr Asp Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala 
    130                 135                 140                 


Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly 
    210                 215                 220                 


Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu 
            260                 265                 270         


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        275                 280                 285             


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
305                 310                 315                 320 


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            340                 345                 350         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    370                 375                 380                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
385                 390                 395                 400 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            420                 425                 430         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210>  65
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  65
gaagtgcagc tgcagcagag cggcgcggaa gtgaaaaaac cgggcgcgag cgtgaaagtg       60

agctgcaaag cgagcggcta tacctttacc gattataaca tggattgggt gcgccaggcg      120

ccgggcgcga gcctggattg gattggcaac attaacccga acagcgaaag caccagctat      180

aaccagaaat ttaaaggcaa agcgaccctg accgtggata aaagcaccag caccgcgtat      240

atggaactgc gcagcctgac cgcgggcgat attgcggtgt attattgcac ccgcgatggc      300

aaccgctatg atgcgtggtt tgcgtattgg ggccagggca ccctggtgac cgtgagcagc      360

gcgagcacca ccgcgccgag cgtgtttccg ctggcgccga gctgcggcag caccagcggc      420

agcaccgtgg cgctggcgtg cctggtgagc ggctattttc cggaaccggt gaccgtgagc      480

tggaacagcg gcagcctgac cagcggcgtg catacctttc cgagcgtgct gcagagcagc      540

ggcctgtata gcctgagcag catggtgacc gtgccgagca gccgctggcc gagcgaaacc      600

tttacctgca acgtggcgca tccggcgagc aaaaccaaag tggataaacc ggtgccgaaa      660

cgcgaaaacg gccgcgtgcc gcgcccgccg gattgcccga aatgcccggc gccggaaatg      720

ctgggcggcc cgagcgtgtt tatttttccg ccgaaaccga aagataccct gctgattgcg      780

cgcaccccgg aagtgacctg cgtggtggtg gcgctggatc cggaagatcc ggaagtgcag      840

attagctggt ttgtggatgg caaacagatg cagaccgcga aaacccagcc gcgcgaagaa      900

cagtttgccg gcacctatcg cgtggtgagc gtgctgccga ttggccatca ggattggctg      960

aaaggcaaac agtttacctg caaagtgaac aacaaagcgc tgccgagccc gattgaacgc     1020

accattagca aagcgcgcgg ccaggcgcat cagccgagcg tgtatgtgct gccgccgagc     1080

cgcgaagaac tgagcaaaaa caccgtgagc ctgacctgcc tgattaaaga tttttttccg     1140

ccggatattg atgtggaatg gcagagcaac ggccagcagg aaccggaaag caaatatcgc     1200

accaccccgc cgcagctgga tgaagatggc agctattttc tgtatagcaa actgagcgtg     1260

gataaaagcc gctggcagcg cggcgatacc tttatttgcg cggtgatgca tgaagcgctg     1320

cataaccatt atacccagga aagcctgagc catagcccgg gcaaa                     1365


<210>  66
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mouse antibody

<400>  66

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met Asp Trp Val Arg Gln Ala Pro Gly Ala Ser Leu Asp Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Asn Ser Glu Ser Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Gly Asn Arg Tyr Asp Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala 
    130                 135                 140                 


Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly 
    210                 215                 220                 


Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu 
            260                 265                 270         


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        275                 280                 285             


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
305                 310                 315                 320 


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            340                 345                 350         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    370                 375                 380                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
385                 390                 395                 400 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            420                 425                 430         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210>  67
<211>  669
<212>  DNA
<213>  Canis familiaris

<400>  67
atggcgggct ttggctttcg ccgccatggc gcgcagccgg atctggcgag ccgcacctgg       60

ccgtgcaccg cgctgtttag cctgctgttt attccggtgt ttagcaaagg catgcatgtg      120

gcgcagccgg cggtggtgct ggcgagcagc cgcggcgtgg cgagctttgt gtgcgaatat      180

ggcagcagcg gcaacgcggc ggaagtgcgc gtgaccgtgc tgcgccaggc gggcagccag      240

atgaccgaag tgtgcgcggc gacctatacc gtggaagatg aactggcgtt tctggatgat      300

agcacctgca ccggcaccag cagcggcaac aaagtgaacc tgaccattca gggcctgcgc      360

gcgatggata ccggcctgta tatttgcaaa gtggaactga tgtatccgcc gccgtattat      420

gtgggcatgg gcaacggcac ccagatttat gtgattgatc cggaaccgtg cccggatagc      480

gattttctgc tgtggattct ggcggcggtg agcagcggcc tgttttttta tagctttctg      540

attaccgcgg tgagcctgag caaaatgctg aaaaaacgca gcccgctgac caccggcgtg      600

tatgtgaaaa tgccgccgac cgaaccggaa tgcgaaaaac agtttcagcc gtattttatt      660

ccgattaac                                                              669


<210>  68
<211>  223
<212>  PRT
<213>  Canis familiaris

<400>  68

Met Ala Gly Phe Gly Phe Arg Arg His Gly Ala Gln Pro Asp Leu Ala 
1               5                   10                  15      


Ser Arg Thr Trp Pro Cys Thr Ala Leu Phe Ser Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Ser Lys Gly Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Val Ala Ser Phe Val Cys Glu Tyr Gly Ser Ser Gly 
    50                  55                  60                  


Asn Ala Ala Glu Val Arg Val Thr Val Leu Arg Gln Ala Gly Ser Gln 
65                  70                  75                  80  


Met Thr Glu Val Cys Ala Ala Thr Tyr Thr Val Glu Asp Glu Leu Ala 
                85                  90                  95      


Phe Leu Asp Asp Ser Thr Cys Thr Gly Thr Ser Ser Gly Asn Lys Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Val Gly Met Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Ile Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210>  69
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified canine

<400>  69

Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
1               5                   10                  15      


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu 
            20                  25                  30          


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        35                  40                  45              


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly 
    50                  55                  60                  


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
65                  70                  75                  80  


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                85                  90                  95      


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            100                 105                 110         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        115                 120                 125             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    130                 135                 140                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
145                 150                 155                 160 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                165                 170                 175     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            180                 185                 190         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        195                 200                 205             


Leu Ser His Ser Pro Gly Lys 
    210                 215 


