                         SEQUENCE LISTING

<110>  Intervet Inc
       Intervet International BV
       Morsey, Mohamad
       Zhang, Yuanzheng
       Tarpey, Ian
 
<120>  Antibodies Against Canine CTLA-4

<130>  24814-US-PCT

<150>  US 62/874,287
<151>  2019-07-15

<150>  US 63/048,873
<151>  2020-07-07

<150>  US 62/926,047
<151>  2019-10-25

<160>  138   

<170>  PatentIn version 3.5

<210>  1
<211>  348
<212>  DNA
<213>  Mus musculus

<400>  1
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat      240

ttgcagatca acaacctcaa aaatgaggac atggctacat atttctgtgc aagacggtca      300

atttattacc cgtactgggg ccaaggcacc actctcacag tctcctca                   348


<210>  2
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  2

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Ser Ile Tyr Tyr Pro Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  3
<211>  348
<212>  DNA
<213>  Mus musculus

<400>  3
cagatccagt tggtacagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca acctatggag tgagctgggt gaaacaggct      120

ccaggaaagg gtttaaggtg gatgggctgg ataaacacct actctggaat gccaacatat      180

gttgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgccttt      240

ttgcagatca acaacctcaa aaatgaggac acggctatat atttctgtgc aagacggggt      300

atctcctttg actactgggg ccaaggcacc actctcacag tctcctca                   348


<210>  4
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  4

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Arg Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Met Pro Thr Tyr Val Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Gly Ile Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  5
<211>  360
<212>  DNA
<213>  Mus musculus

<400>  5
gaggtgaagc tggtggagtc tggaggaggc ttggtacagc ctgggggttc cctgagtctc       60

tcctgtgcaa cttctggatt caccttcagt gattactaca tgagctgggt ccgccagtct      120

ccggggaagg cacttgagtg gatgggtttt attagaaaca aagctaatgg ttacacaaca      180

gagtacagcg catctctgaa gggtcggttc accatctcca gagataattc ccaaagcatc      240

ctctatcttc aaatgaatgt cctgagagct gaggacagtg ccacttatta ctgtgtaaga      300

tttgggttaa tgtactactt tgactactgg ggccaaggca ccactctcac agtctcctca      360


<210>  6
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  6

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ser Pro Gly Lys Ala Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Leu Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Val Leu Arg Ala Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Val Arg Phe Gly Leu Met Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  7
<211>  348
<212>  DNA
<213>  Mus musculus

<400>  7
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat      240

ttgcagatca acaacctcaa aaatgaggac acggctacat atttctgtgc aagaaggggg      300

acctactata ggccctgggg ccaaggcacc actctcacag tctcctca                   348


<210>  8
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  8

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Gly Thr Tyr Tyr Arg Pro Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  9
<211>  348
<212>  DNA
<213>  Mus musculus

<400>  9
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctggata taccttcaca aactatggaa tgaactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggacg ggttgccttc tctttggaaa cctctgccag cactgccttt      240

ttgcagatca acaacctcaa aaatgaggac acggctacat atttctgtgc aaggcggggg      300

gtacgactgg actactgggg ccaaggcacc actctcacag tctcctca                   348


<210>  10
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  10

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Gly Val Arg Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  11
<211>  363
<212>  DNA
<213>  Mus musculus

<400>  11
caggtccaac tgcagcagcc tgggactgaa ctggtgaagc ctggggcttc agtgaagctg       60

tcctgcaagg cctctggcta taccttcacc agctactgga tgcactgggt gaagcagagg      120

cctggacaag gccttgagtg gattggaaat atcaatccta gcaatggtgg tactaggttc      180

aatgagaagt tcaagaacaa ggccacactg actgaagaca aatcctccag cacagcctac      240

atgcagctca gtagcctgac atctgaggac tctgcggtct attattgtgc aagatcgaac      300

tacggtagtg gctgggcctg gtttgcttac tggggccaag ggactctggt cactgtctct      360

gca                                                                    363


<210>  12
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  12

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Ser Asn Gly Gly Thr Arg Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Glu Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Gly Ser Gly Trp Ala Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  13
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  13
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagcattgta tatagtaatg gaaacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  14
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  14

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  15
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  15
gatgttttga tgacccagac tccactctcc ctgcctgtca gtcttggaga tcacgcctcc       60

atctcttgca aatctagtca gagcattgta tatattaatg gaaacaccta tttagaatgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaacgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  16
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  16

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp His Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Ile Val Tyr Ile 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Lys Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  17
<211>  324
<212>  DNA
<213>  Mus musculus

<400>  17
gaaaatgtgc tcatccagtc tccagcaatc atgtctgctt ctccagggga aaaggtcacc       60

atgacctgca gggccagctc aagtgtaagt tccagttact tgcactggta ccagcagaag      120

tcaggtgcct cccccaaact ctggattttt agcacatcca acttggcttc tggagtccct      180

gctcgcttca gtggcagtgg gtctgggacc tcttattctc tcacaatcaa cagtgtggag      240

gctgaagatg ctgccactta ttactgccag cagtacagtg gtctcccact cacgttcgga      300

ggggggacca agctggaaat aaaa                                             324


<210>  18
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  18

Glu Asn Val Leu Ile Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Phe Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Ser Val Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Gly Leu Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  19
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  19
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagtattgta tatagtcatg gaaacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag gtcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  20
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  20

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Tyr Ser 
            20                  25                  30          


His Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  21
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  21
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagcattgta tatattagtg gaagcaccta tttagaatgg      120

tatctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc cagtcgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  22
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  22

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Tyr Ile 
            20                  25                  30          


Ser Gly Ser Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Ser Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  23
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  23
gacatccaga tgaaccagtc tccatccagt ctgtctgcat cccttggaga cacaattacc       60

atcacttgcc atgccagtca gaacattaat gtttggttaa gctggtacca gcagaaacca      120

ggaaatattc ctaaactttt gatctataag tcttccaact tgcacacagg cgtcccatca      180

aggtttagtg gcagtggatc tggaacaggt ttcacattaa ccatcagcag cctgcagcct      240

gaagacattg ccacttacta ctgtcaacag ggtcaaagtt atccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210>  24
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  24

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ser Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  25
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  25
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat      240

ttgcagatca acaacctcaa aaatgaggac atggctacat atttctgtgc aagacggtca      300

atttattacc cgtactgggg ccaaggcacc actctcacag tctcctcagc gagcaccacc      360

gcgccgagcg tgtttccgct ggcgccgagc tgcggcagca ccagcggcag caccgtggcg      420

ctggcgtgcc tggtgagcgg ctattttccg gaaccggtga ccgtgagctg gaacagcggc      480

agcctgacca gcggcgtgca tacctttccg agcgtgctgc agagcagcgg cctgtatagc      540

ctgagcagca tggtgaccgt gccgagcagc cgctggccga gcgaaacctt tacctgcaac      600

gtggcgcatc cggcgagcaa aaccaaagtg gataaaccgg tgccgaaacg cgaaaacggc      660

cgcgtgccgc gcccgccgga ttgcccgaaa tgcccggcgc cggaaatgct gggcggcccg      720

agcgtgttta tttttccgcc gaaaccgaaa gataccctgc tgattgcgcg caccccggaa      780

gtgacctgcg tggtggtgga tctggatccg gaagatccgg aagtgcagat tagctggttt      840

gtggatggca aacagatgca gaccgcgaaa acccagccgc gcgaagaaca gtttaacggc      900

acctatcgcg tggtgagcgt gctgccgatt ggccatcagg attggctgaa aggcaaacag      960

tttacctgca aagtgaacaa caaagcgctg ccgagcccga ttgaacgcac cattagcaaa     1020

gcgcgcggcc aggcgcatca gccgagcgtg tatgtgctgc cgccgagccg cgaagaactg     1080

agcaaaaaca ccgtgagcct gacctgcctg attaaagatt tttttccgcc ggatattgat     1140

gtggaatggc agagcaacgg ccagcaggaa ccggaaagca aatatcgcac caccccgccg     1200

cagctggatg aagatggcag ctattttctg tatagcaaac tgagcgtgga taaaagccgc     1260

tggcagcgcg gcgatacctt tatttgcgcg gtgatgcatg aagcgctgca taaccattat     1320

acccaggaaa gcctgagcca tagcccgggc aaa                                  1353


<210>  26
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  26

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Met Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Ser Ile Tyr Tyr Pro Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu 
    130                 135                 140                 


Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp 
            180                 185                 190         


Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr 
        195                 200                 205             


Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg 
    210                 215                 220                 


Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr 
        275                 280                 285             


Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln 
305                 310                 315                 320 


Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  27
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  27
cagatccagt tggtacagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca acctatggag tgagctgggt gaaacaggct      120

ccaggaaagg gtttaaggtg gatgggctgg ataaacacct actctggaat gccaacatat      180

gttgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgccttt      240

ttgcagatca acaacctcaa aaatgaggac acggctatat atttctgtgc aagacggggt      300

atctcctttg actactgggg ccaaggcacc actctcacag tctcctcagc gagcaccacc      360

gcgccgagcg tgtttccgct ggcgccgagc tgcggcagca ccagcggcag caccgtggcg      420

ctggcgtgcc tggtgagcgg ctattttccg gaaccggtga ccgtgagctg gaacagcggc      480

agcctgacca gcggcgtgca tacctttccg agcgtgctgc agagcagcgg cctgtatagc      540

ctgagcagca tggtgaccgt gccgagcagc cgctggccga gcgaaacctt tacctgcaac      600

gtggcgcatc cggcgagcaa aaccaaagtg gataaaccgg tgccgaaacg cgaaaacggc      660

cgcgtgccgc gcccgccgga ttgcccgaaa tgcccggcgc cggaaatgct gggcggcccg      720

agcgtgttta tttttccgcc gaaaccgaaa gataccctgc tgattgcgcg caccccggaa      780

gtgacctgcg tggtggtgga tctggatccg gaagatccgg aagtgcagat tagctggttt      840

gtggatggca aacagatgca gaccgcgaaa acccagccgc gcgaagaaca gtttaacggc      900

acctatcgcg tggtgagcgt gctgccgatt ggccatcagg attggctgaa aggcaaacag      960

tttacctgca aagtgaacaa caaagcgctg ccgagcccga ttgaacgcac cattagcaaa     1020

gcgcgcggcc aggcgcatca gccgagcgtg tatgtgctgc cgccgagccg cgaagaactg     1080

agcaaaaaca ccgtgagcct gacctgcctg attaaagatt tttttccgcc ggatattgat     1140

gtggaatggc agagcaacgg ccagcaggaa ccggaaagca aatatcgcac caccccgccg     1200

cagctggatg aagatggcag ctattttctg tatagcaaac tgagcgtgga taaaagccgc     1260

tggcagcgcg gcgatacctt tatttgcgcg gtgatgcatg aagcgctgca taaccattat     1320

acccaggaaa gcctgagcca tagcccgggc aaa                                  1353


<210>  28
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  28

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Arg Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Met Pro Thr Tyr Val Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Gly Ile Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu 
    130                 135                 140                 


Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp 
            180                 185                 190         


Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr 
        195                 200                 205             


Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg 
    210                 215                 220                 


Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr 
        275                 280                 285             


Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln 
305                 310                 315                 320 


Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  29
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  29
gaggtgaagc tggtggagtc tggaggaggc ttggtacagc ctgggggttc cctgagtctc       60

tcctgtgcaa cttctggatt caccttcagt gattactaca tgagctgggt ccgccagtct      120

ccggggaagg cacttgagtg gatgggtttt attagaaaca aagctaatgg ttacacaaca      180

gagtacagcg catctctgaa gggtcggttc accatctcca gagataattc ccaaagcatc      240

ctctatcttc aaatgaatgt cctgagagct gaggacagtg ccacttatta ctgtgtaaga      300

tttgggttaa tgtactactt tgactactgg ggccaaggca ccactctcac agtctcctca      360

gcgagcacca ccgcgccgag cgtgtttccg ctggcgccga gctgcggcag caccagcggc      420

agcaccgtgg cgctggcgtg cctggtgagc ggctattttc cggaaccggt gaccgtgagc      480

tggaacagcg gcagcctgac cagcggcgtg catacctttc cgagcgtgct gcagagcagc      540

ggcctgtata gcctgagcag catggtgacc gtgccgagca gccgctggcc gagcgaaacc      600

tttacctgca acgtggcgca tccggcgagc aaaaccaaag tggataaacc ggtgccgaaa      660

cgcgaaaacg gccgcgtgcc gcgcccgccg gattgcccga aatgcccggc gccggaaatg      720

ctgggcggcc cgagcgtgtt tatttttccg ccgaaaccga aagataccct gctgattgcg      780

cgcaccccgg aagtgacctg cgtggtggtg gatctggatc cggaagatcc ggaagtgcag      840

attagctggt ttgtggatgg caaacagatg cagaccgcga aaacccagcc gcgcgaagaa      900

cagtttaacg gcacctatcg cgtggtgagc gtgctgccga ttggccatca ggattggctg      960

aaaggcaaac agtttacctg caaagtgaac aacaaagcgc tgccgagccc gattgaacgc     1020

accattagca aagcgcgcgg ccaggcgcat cagccgagcg tgtatgtgct gccgccgagc     1080

cgcgaagaac tgagcaaaaa caccgtgagc ctgacctgcc tgattaaaga tttttttccg     1140

ccggatattg atgtggaatg gcagagcaac ggccagcagg aaccggaaag caaatatcgc     1200

accaccccgc cgcagctgga tgaagatggc agctattttc tgtatagcaa actgagcgtg     1260

gataaaagcc gctggcagcg cggcgatacc tttatttgcg cggtgatgca tgaagcgctg     1320

cataaccatt atacccagga aagcctgagc catagcccgg gcaaa                     1365


<210>  30
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  30

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ser Pro Gly Lys Ala Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Leu Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Val Leu Arg Ala Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Val Arg Phe Gly Leu Met Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala 
    130                 135                 140                 


Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly 
    210                 215                 220                 


Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu 
            260                 265                 270         


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        275                 280                 285             


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
305                 310                 315                 320 


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            340                 345                 350         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    370                 375                 380                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
385                 390                 395                 400 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            420                 425                 430         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210>  31
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  31
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca aactatggaa tgaactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat      240

ttgcagatca acaacctcaa aaatgaggac acggctacat atttctgtgc aagaaggggg      300

acctactata ggccctgggg ccaaggcacc actctcacag tctcctcagc gagcaccacc      360

gcgccgagcg tgtttccgct ggcgccgagc tgcggcagca ccagcggcag caccgtggcg      420

ctggcgtgcc tggtgagcgg ctattttccg gaaccggtga ccgtgagctg gaacagcggc      480

agcctgacca gcggcgtgca tacctttccg agcgtgctgc agagcagcgg cctgtatagc      540

ctgagcagca tggtgaccgt gccgagcagc cgctggccga gcgaaacctt tacctgcaac      600

gtggcgcatc cggcgagcaa aaccaaagtg gataaaccgg tgccgaaacg cgaaaacggc      660

cgcgtgccgc gcccgccgga ttgcccgaaa tgcccggcgc cggaaatgct gggcggcccg      720

agcgtgttta tttttccgcc gaaaccgaaa gataccctgc tgattgcgcg caccccggaa      780

gtgacctgcg tggtggtgga tctggatccg gaagatccgg aagtgcagat tagctggttt      840

gtggatggca aacagatgca gaccgcgaaa acccagccgc gcgaagaaca gtttaacggc      900

acctatcgcg tggtgagcgt gctgccgatt ggccatcagg attggctgaa aggcaaacag      960

tttacctgca aagtgaacaa caaagcgctg ccgagcccga ttgaacgcac cattagcaaa     1020

gcgcgcggcc aggcgcatca gccgagcgtg tatgtgctgc cgccgagccg cgaagaactg     1080

agcaaaaaca ccgtgagcct gacctgcctg attaaagatt tttttccgcc ggatattgat     1140

gtggaatggc agagcaacgg ccagcaggaa ccggaaagca aatatcgcac caccccgccg     1200

cagctggatg aagatggcag ctattttctg tatagcaaac tgagcgtgga taaaagccgc     1260

tggcagcgcg gcgatacctt tatttgcgcg gtgatgcatg aagcgctgca taaccattat     1320

acccaggaaa gcctgagcca tagcccgggc aaa                                  1353


<210>  32
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  32

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Gly Thr Tyr Tyr Arg Pro Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu 
    130                 135                 140                 


Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp 
            180                 185                 190         


Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr 
        195                 200                 205             


Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg 
    210                 215                 220                 


Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr 
        275                 280                 285             


Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln 
305                 310                 315                 320 


Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  33
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  33
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctggata taccttcaca aactatggaa tgaactgggt gaagcaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct acactggaga gccaacatat      180

gctgatgact tcaagggacg ggttgccttc tctttggaaa cctctgccag cactgccttt      240

ttgcagatca acaacctcaa aaatgaggac acggctacat atttctgtgc aaggcggggg      300

gtacgactgg actactgggg ccaaggcacc actctcacag tctcctcagc gagcaccacc      360

gcgccgagcg tgtttccgct ggcgccgagc tgcggcagca ccagcggcag caccgtggcg      420

ctggcgtgcc tggtgagcgg ctattttccg gaaccggtga ccgtgagctg gaacagcggc      480

agcctgacca gcggcgtgca tacctttccg agcgtgctgc agagcagcgg cctgtatagc      540

ctgagcagca tggtgaccgt gccgagcagc cgctggccga gcgaaacctt tacctgcaac      600

gtggcgcatc cggcgagcaa aaccaaagtg gataaaccgg tgccgaaacg cgaaaacggc      660

cgcgtgccgc gcccgccgga ttgcccgaaa tgcccggcgc cggaaatgct gggcggcccg      720

agcgtgttta tttttccgcc gaaaccgaaa gataccctgc tgattgcgcg caccccggaa      780

gtgacctgcg tggtggtgga tctggatccg gaagatccgg aagtgcagat tagctggttt      840

gtggatggca aacagatgca gaccgcgaaa acccagccgc gcgaagaaca gtttaacggc      900

acctatcgcg tggtgagcgt gctgccgatt ggccatcagg attggctgaa aggcaaacag      960

tttacctgca aagtgaacaa caaagcgctg ccgagcccga ttgaacgcac cattagcaaa     1020

gcgcgcggcc aggcgcatca gccgagcgtg tatgtgctgc cgccgagccg cgaagaactg     1080

agcaaaaaca ccgtgagcct gacctgcctg attaaagatt tttttccgcc ggatattgat     1140

gtggaatggc agagcaacgg ccagcaggaa ccggaaagca aatatcgcac caccccgccg     1200

cagctggatg aagatggcag ctattttctg tatagcaaac tgagcgtgga taaaagccgc     1260

tggcagcgcg gcgatacctt tatttgcgcg gtgatgcatg aagcgctgca taaccattat     1320

acccaggaaa gcctgagcca tagcccgggc aaa                                  1353


<210>  34
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  34

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Gly Val Arg Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu 
    130                 135                 140                 


Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp 
            180                 185                 190         


Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr 
        195                 200                 205             


Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg 
    210                 215                 220                 


Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr 
        275                 280                 285             


Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln 
305                 310                 315                 320 


Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  35
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  35
caggtccaac tgcagcagcc tgggactgaa ctggtgaagc ctggggcttc agtgaagctg       60

tcctgcaagg cctctggcta taccttcacc agctactgga tgcactgggt gaagcagagg      120

cctggacaag gccttgagtg gattggaaat atcaatccta gcaatggtgg tactaggttc      180

aatgagaagt tcaagaacaa ggccacactg actgaagaca aatcctccag cacagcctac      240

atgcagctca gtagcctgac atctgaggac tctgcggtct attattgtgc aagatcgaac      300

tacggtagtg gctgggcctg gtttgcttac tggggccaag ggactctggt cactgtctct      360

gcagcgagca ccaccgcgcc gagcgtgttt ccgctggcgc cgagctgcgg cagcaccagc      420

ggcagcaccg tggcgctggc gtgcctggtg agcggctatt ttccggaacc ggtgaccgtg      480

agctggaaca gcggcagcct gaccagcggc gtgcatacct ttccgagcgt gctgcagagc      540

agcggcctgt atagcctgag cagcatggtg accgtgccga gcagccgctg gccgagcgaa      600

acctttacct gcaacgtggc gcatccggcg agcaaaacca aagtggataa accggtgccg      660

aaacgcgaaa acggccgcgt gccgcgcccg ccggattgcc cgaaatgccc ggcgccggaa      720

atgctgggcg gcccgagcgt gtttattttt ccgccgaaac cgaaagatac cctgctgatt      780

gcgcgcaccc cggaagtgac ctgcgtggtg gtggatctgg atccggaaga tccggaagtg      840

cagattagct ggtttgtgga tggcaaacag atgcagaccg cgaaaaccca gccgcgcgaa      900

gaacagttta acggcaccta tcgcgtggtg agcgtgctgc cgattggcca tcaggattgg      960

ctgaaaggca aacagtttac ctgcaaagtg aacaacaaag cgctgccgag cccgattgaa     1020

cgcaccatta gcaaagcgcg cggccaggcg catcagccga gcgtgtatgt gctgccgccg     1080

agccgcgaag aactgagcaa aaacaccgtg agcctgacct gcctgattaa agattttttt     1140

ccgccggata ttgatgtgga atggcagagc aacggccagc aggaaccgga aagcaaatat     1200

cgcaccaccc cgccgcagct ggatgaagat ggcagctatt ttctgtatag caaactgagc     1260

gtggataaaa gccgctggca gcgcggcgat acctttattt gcgcggtgat gcatgaagcg     1320

ctgcataacc attataccca ggaaagcctg agccatagcc cgggcaaa                  1368


<210>  36
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  36

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asn Pro Ser Asn Gly Gly Thr Arg Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Glu Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asn Tyr Gly Ser Gly Trp Ala Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Thr Ala Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val 
    130                 135                 140                 


Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val 
            180                 185                 190         


Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn 
    210                 215                 220                 


Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly 
        275                 280                 285             


Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn 
    290                 295                 300                 


Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp 
305                 310                 315                 320 


Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro 
                325                 330                 335     


Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln 
            340                 345                 350         


Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn 
        355                 360                 365             


Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile 
    370                 375                 380                 


Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr 
385                 390                 395                 400 


Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe 
            420                 425                 430         


Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu 
        435                 440                 445             


Ser Leu Ser His Ser Pro Gly Lys 
    450                 455     


<210>  37
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  37
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagcattgta tatagtaatg gaaacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaacgca acgatgcgca gccggcggtg      360

tatctgtttc agccgagccc ggatcagctg cataccggca gcgcgagcgt ggtgtgcctg      420

ctgaacagct tttatccgaa agatattaac gtgaaatgga aagtggatgg cgtgattcag      480

gataccggca ttcaggaaag cgtgaccgaa caggatagca aagatagcac ctatagcctg      540

agcagcaccc tgaccatgag cagcaccgaa tatctgagcc atgaactgta tagctgcgaa      600

attacccata aaagcctgcc gagcaccctg attaaaagct ttcagcgcag cgaatgccag      660

cgcgtggat                                                              669


<210>  38
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  38

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp 
        115                 120                 125             


Gln Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln 
145                 150                 155                 160 


Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu 
            180                 185                 190         


Ser His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser 
        195                 200                 205             


Thr Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215                 220             


<210>  39
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  39
gatgttttga tgacccagac tccactctcc ctgcctgtca gtcttggaga tcacgcctcc       60

atctcttgca aatctagtca gagcattgta tatattaatg gaaacaccta tttagaatgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaacgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaacgca acgatgcgca gccggcggtg      360

tatctgtttc agccgagccc ggatcagctg cataccggca gcgcgagcgt ggtgtgcctg      420

ctgaacagct tttatccgaa agatattaac gtgaaatgga aagtggatgg cgtgattcag      480

gataccggca ttcaggaaag cgtgaccgaa caggatagca aagatagcac ctatagcctg      540

agcagcaccc tgaccatgag cagcaccgaa tatctgagcc atgaactgta tagctgcgaa      600

attacccata aaagcctgcc gagcaccctg attaaaagct ttcagcgcag cgaatgccag      660

cgcgtggat                                                              669


<210>  40
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  40

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp His Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Ile Val Tyr Ile 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Lys Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp 
        115                 120                 125             


Gln Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln 
145                 150                 155                 160 


Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu 
            180                 185                 190         


Ser His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser 
        195                 200                 205             


Thr Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215                 220             


<210>  41
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  41
gaaaatgtgc tcatccagtc tccagcaatc atgtctgctt ctccagggga aaaggtcacc       60

atgacctgca gggccagctc aagtgtaagt tccagttact tgcactggta ccagcagaag      120

tcaggtgcct cccccaaact ctggattttt agcacatcca acttggcttc tggagtccct      180

gctcgcttca gtggcagtgg gtctgggacc tcttattctc tcacaatcaa cagtgtggag      240

gctgaagatg ctgccactta ttactgccag cagtacagtg gtctcccact cacgttcgga      300

ggggggacca agctggaaat aaaacgcaac gatgcgcagc cggcggtgta tctgtttcag      360

ccgagcccgg atcagctgca taccggcagc gcgagcgtgg tgtgcctgct gaacagcttt      420

tatccgaaag atattaacgt gaaatggaaa gtggatggcg tgattcagga taccggcatt      480

caggaaagcg tgaccgaaca ggatagcaaa gatagcacct atagcctgag cagcaccctg      540

accatgagca gcaccgaata tctgagccat gaactgtata gctgcgaaat tacccataaa      600

agcctgccga gcaccctgat taaaagcttt cagcgcagcg aatgccagcg cgtggat         657


<210>  42
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  42

Glu Asn Val Leu Ile Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Phe Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asn Ser Val Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Gly Leu Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Asn Asp Ala 
            100                 105                 110         


Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr 
        115                 120                 125             


Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp 
    130                 135                 140                 


Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu 
            180                 185                 190         


Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys 
        195                 200                 205             


Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215                 


<210>  43
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  43
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagtattgta tatagtcatg gaaacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag gtcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaacgca acgatgcgca gccggcggtg      360

tatctgtttc agccgagccc ggatcagctg cataccggca gcgcgagcgt ggtgtgcctg      420

ctgaacagct tttatccgaa agatattaac gtgaaatgga aagtggatgg cgtgattcag      480

gataccggca ttcaggaaag cgtgaccgaa caggatagca aagatagcac ctatagcctg      540

agcagcaccc tgaccatgag cagcaccgaa tatctgagcc atgaactgta tagctgcgaa      600

attacccata aaagcctgcc gagcaccctg attaaaagct ttcagcgcag cgaatgccag      660

cgcgtggat                                                              669


<210>  44
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  44

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Tyr Ser 
            20                  25                  30          


His Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp 
        115                 120                 125             


Gln Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln 
145                 150                 155                 160 


Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu 
            180                 185                 190         


Ser His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser 
        195                 200                 205             


Thr Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215                 220             


<210>  45
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  45
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagcattgta tatattagtg gaagcaccta tttagaatgg      120

tatctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc cagtcgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaacgca acgatgcgca gccggcggtg      360

tatctgtttc agccgagccc ggatcagctg cataccggca gcgcgagcgt ggtgtgcctg      420

ctgaacagct tttatccgaa agatattaac gtgaaatgga aagtggatgg cgtgattcag      480

gataccggca ttcaggaaag cgtgaccgaa caggatagca aagatagcac ctatagcctg      540

agcagcaccc tgaccatgag cagcaccgaa tatctgagcc atgaactgta tagctgcgaa      600

attacccata aaagcctgcc gagcaccctg attaaaagct ttcagcgcag cgaatgccag      660

cgcgtggat                                                              669


<210>  46
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  46

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Tyr Ile 
            20                  25                  30          


Ser Gly Ser Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Ser Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp 
        115                 120                 125             


Gln Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln 
145                 150                 155                 160 


Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu 
            180                 185                 190         


Ser His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser 
        195                 200                 205             


Thr Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215                 220             


<210>  47
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  47
gacatccaga tgaaccagtc tccatccagt ctgtctgcat cccttggaga cacaattacc       60

atcacttgcc atgccagtca gaacattaat gtttggttaa gctggtacca gcagaaacca      120

ggaaatattc ctaaactttt gatctataag tcttccaact tgcacacagg cgtcccatca      180

aggtttagtg gcagtggatc tggaacaggt ttcacattaa ccatcagcag cctgcagcct      240

gaagacattg ccacttacta ctgtcaacag ggtcaaagtt atccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa acgcaacgat gcgcagccgg cggtgtatct gtttcagccg      360

agcccggatc agctgcatac cggcagcgcg agcgtggtgt gcctgctgaa cagcttttat      420

ccgaaagata ttaacgtgaa atggaaagtg gatggcgtga ttcaggatac cggcattcag      480

gaaagcgtga ccgaacagga tagcaaagat agcacctata gcctgagcag caccctgacc      540

atgagcagca ccgaatatct gagccatgaa ctgtatagct gcgaaattac ccataaaagc      600

ctgccgagca ccctgattaa aagctttcag cgcagcgaat gccagcgcgt ggat            654


<210>  48
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mus musculus-canis familiaris, chimeric

<400>  48

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ser Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Asn Asp Ala Gln 
            100                 105                 110         


Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr Gly 
        115                 120                 125             


Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu Tyr 
            180                 185                 190         


Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys Ser 
        195                 200                 205             


Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215             


<210>  49
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  49
gatattgtga tgacccagac cccgctgagc ctgagcgtga gcccgggcga accggcgagc       60

attagctgcc gcagcagcca gagcattgtg tatagcaacg gcaacaccta tctggaatgg      120

tttcagcaga aaccgggcca gagcccgcag cgcctgattt ataaagtgag caaccgcttt      180

agcggcgtgc cggatcgctt tagcggcagc ggcagcggca ccgattttac cctgcgcatt      240

agccgcgtgg aagcggatga tgcgggcgtg tattattgct ttcagggcag ccatgtgccg      300

tggacctttg gcggcggcac caaactggaa attaaaagga acgacgctca gccagccgtg      360

tacctcttcc agccttcgcc ggaccagctt catacggggt cagcgtcggt ggtgtgcctg      420

ttgaactcgt tttaccccaa ggacattaac gtgaagtgga aggtagacgg ggtaattcaa      480

gacactggca ttcaagagtc cgtcacggaa caagactcaa aagactcaac gtattcactg      540

tcgtcaacct tgacgatgtc aagcaccgag tatcttagcc atgagctgta ttcgtgcgag      600

atcacccaca agtccctccc ctccactctt atcaaatcct ttcagcggtc ggaatgtcag      660

cgggtcgat                                                              669


<210>  50
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  50

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Phe Gln Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Arg Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Asp Asp Ala Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp 
        115                 120                 125             


Gln Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln 
145                 150                 155                 160 


Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu 
            180                 185                 190         


Ser His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser 
        195                 200                 205             


Thr Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215                 220             


<210>  51
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  51
gatattgtga tgacccagac cccgctgagc ctgagcgtga gcccgggcga accggcgagc       60

attagctgcc gcagcagcca gagcattgtg tatagcaacg gcaacaccta tctggaatgg      120

tatcagcaga aaccgggcca gagcccgaaa ctgctgattt ataaagtgag caaccgcttt      180

agcggcgtgc cggatcgctt tagcggcagc ggcagcggca ccgattttac cctgcgcatt      240

agccgcgtgg aagcggatga tgcgggcgtg tattattgct ttcagggcag ccatgtgccg      300

tggacctttg gcggcggcac caaactggaa attaaaagga acgacgctca gccagccgtg      360

tacctcttcc agccttcgcc ggaccagctt catacggggt cagcgtcggt ggtgtgcctg      420

ttgaactcgt tttaccccaa ggacattaac gtgaagtgga aggtagacgg ggtaattcaa      480

gacactggca ttcaagagtc cgtcacggaa caagactcaa aagactcaac gtattcactg      540

tcgtcaacct tgacgatgtc aagcaccgag tatcttagcc atgagctgta ttcgtgcgag      600

atcacccaca agtccctccc ctccactctt atcaaatcct ttcagcggtc ggaatgtcag      660

cgggtcgat                                                              669


<210>  52
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  52

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Asp Asp Ala Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp 
        115                 120                 125             


Gln Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln 
145                 150                 155                 160 


Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu 
            180                 185                 190         


Ser His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser 
        195                 200                 205             


Thr Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215                 220             


<210>  53
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  53
gatgtgctga tgacccagac cccgctgagc ctgagcgtga gcccgggcga accggcgagc       60

attagctgcc gcagcagcca gagcattgtg tatagcaacg gcaacaccta tctggaatgg      120

tatctgcaga aaccgggcca gagcccgaaa ctgctgattt ataaagtgag caaccgcttt      180

agcggcgtgc cggatcgctt tagcggcagc ggcagcggca ccgattttac cctgcgcatt      240

agccgcgtgg aagcggatga tgcgggcgtg tattattgct ttcagggcag ccatgtgccg      300

tggacctttg gcggcggcac caaactggaa ctgaaaagga acgacgctca gccagccgtg      360

tacctcttcc agccttcgcc ggaccagctt catacggggt cagcgtcggt ggtgtgcctg      420

ttgaactcgt tttaccccaa ggacattaac gtgaagtgga aggtagacgg ggtaattcaa      480

gacactggca ttcaagagtc cgtcacggaa caagactcaa aagactcaac gtattcactg      540

tcgtcaacct tgacgatgtc aagcaccgag tatcttagcc atgagctgta ttcgtgcgag      600

atcacccaca agtccctccc ctccactctt atcaaatcct ttcagcggtc ggaatgtcag      660

cgggtcgat                                                              669


<210>  54
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  54

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Asp Asp Ala Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp 
        115                 120                 125             


Gln Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln 
145                 150                 155                 160 


Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu 
            180                 185                 190         


Ser His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser 
        195                 200                 205             


Thr Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215                 220             


<210>  55
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  55
gaaattgtga tgacccagag cccggcgagc ctgagcctga gccaggaaga aaaagtgacc       60

attacctgcc gcgcgagcag cagcgtgagc agcagctatc tgcattggta tcagcagaaa      120

ccgggccagg cgccgaaact gctgatttat agcaccagca acctggcgag cggcgtgccg      180

agccgcttta gcggcagcgg cagcggcacc gattttagct ttaccattag cagcctggaa      240

ccggaagatg tggcggtgta ttattgccag cagtatagcg gcctgccgct gacctttggc      300

ggcggcacca aactggaaat taaaaggaac gacgctcagc cagccgtgta cctcttccag      360

ccttcgccgg accagcttca tacggggtca gcgtcggtgg tgtgcctgtt gaactcgttt      420

taccccaagg acattaacgt gaagtggaag gtagacgggg taattcaaga cactggcatt      480

caagagtccg tcacggaaca agactcaaaa gactcaacgt attcactgtc gtcaaccttg      540

acgatgtcaa gcaccgagta tcttagccat gagctgtatt cgtgcgagat cacccacaag      600

tccctcccct ccactcttat caaatccttt cagcggtcgg aatgtcagcg ggtcgat         657


<210>  56
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  56

Glu Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Glu 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Gly Leu Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Asn Asp Ala 
            100                 105                 110         


Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr 
        115                 120                 125             


Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp 
    130                 135                 140                 


Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu 
            180                 185                 190         


Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys 
        195                 200                 205             


Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215                 


<210>  57
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  57
gaaaacgtgc tgacccagag cccggcgagc ctgagcctga gccaggaaga aaaagtgacc       60

attacctgcc gcgcgagcag cagcgtgagc agcagctatc tgcattggta tcagcagaaa      120

ccgggccagg cgccgaaact gtggattttt agcaccagca acctggcgag cggcgtgccg      180

agccgcttta gcggcagcgg cagcggcacc gattatagct ttaccattag cagcctggaa      240

ccggaagatg tggcggtgta ttattgccag cagtatagcg gcctgccgct gacctttggc      300

ggcggcacca aactggaact gaaaaggaac gacgctcagc cagccgtgta cctcttccag      360

ccttcgccgg accagcttca tacggggtca gcgtcggtgg tgtgcctgtt gaactcgttt      420

taccccaagg acattaacgt gaagtggaag gtagacgggg taattcaaga cactggcatt      480

caagagtccg tcacggaaca agactcaaaa gactcaacgt attcactgtc gtcaaccttg      540

acgatgtcaa gcaccgagta tcttagccat gagctgtatt cgtgcgagat cacccacaag      600

tccctcccct ccactcttat caaatccttt cagcggtcgg aatgtcagcg ggtcgat         657


<210>  58
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  58

Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Glu 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp 
        35                  40                  45              


Ile Phe Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Ser Phe Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Gly Leu Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Asn Asp Ala 
            100                 105                 110         


Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr 
        115                 120                 125             


Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp 
    130                 135                 140                 


Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu 
            180                 185                 190         


Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys 
        195                 200                 205             


Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215                 


<210>  59
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  59
gaaaacgtgc tgacccagag cccggcgagc ctgagcctga gcccgggcga aaaagtgacc       60

attacctgcc gcgcgagcag cagcgtgagc agcagctatc tgcattggta tcagcagaaa      120

ccgggccaga gcccgaaact gtggattttt agcaccagca acctggcgag cggcgtgccg      180

agccgcttta gcggcagcgg cagcggcacc agctatagct ttaccattag cagcctggaa      240

ccggaagatg tggcggtgta ttattgccag cagtatagcg gcctgccgct gacctttggc      300

ggcggcacca aactggaact gaaaaggaac gacgctcagc cagccgtgta cctcttccag      360

ccttcgccgg accagcttca tacggggtca gcgtcggtgg tgtgcctgtt gaactcgttt      420

taccccaagg acattaacgt gaagtggaag gtagacgggg taattcaaga cactggcatt      480

caagagtccg tcacggaaca agactcaaaa gactcaacgt attcactgtc gtcaaccttg      540

acgatgtcaa gcaccgagta tcttagccat gagctgtatt cgtgcgagat cacccacaag      600

tccctcccct ccactcttat caaatccttt cagcggtcgg aatgtcagcg ggtcgat         657


<210>  60
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  60

Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Phe Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Phe Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Gly Leu Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Asn Asp Ala 
            100                 105                 110         


Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp Gln Leu His Thr 
        115                 120                 125             


Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe Tyr Pro Lys Asp 
    130                 135                 140                 


Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln Asp Thr Gly Ile 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser His Glu Leu 
            180                 185                 190         


Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr Leu Ile Lys 
        195                 200                 205             


Ser Phe Gln Arg Ser Glu Cys Gln Arg Val Asp 
    210                 215                 


<210>  61
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  61
gaagtgcagc tggtggaaag cggcggcgat ctggtgaaac cgggcggcag cctgcgcctg       60

agctgcgtgg cgagcggcta tacctttacc aactatggca tgaactgggt gcgccaggcg      120

ccgggcaaag gcctgcagtg ggtggcgtgg attaacacct ataccggcga accgacctat      180

gcggatgatt ttaaaggccg ctttaccatt agccgcgata acgcgaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgccgcagc      300

atttattatc cgtattgggg ccagggcacc accctgaccg tgagcagcgc ttccacaacc      360

gcgccatcag tctttccgtt ggccccatca tgcgggtcga cgagcggatc gactgtggcc      420

ctggcgtgct tggtgtcggg atactttccc gaacccgtca cggtcagctg gaactccgga      480

tcgcttacga gcggtgtgca tacgttcccc tcggtcttgc aatcatcagg gctctactcg      540

ctgtcgagca tggtaacggt gccctcatcg aggtggccct ccgaaacgtt cacatgtaac      600

gtagcacatc cagcctccaa aaccaaggtg gataaacccg tgccgaaaag agagaatggg      660

cgggtgcctc gaccccctga ttgccccaag tgtccggctc cggaaatgct cggtggaccc      720

tcagtgttta tcttccctcc gaagcccaag gacactctgc tgatcgcgcg cactccagaa      780

gtaacatgtg tagtggtgga ccttgatccc gaggaccccg aagtccagat ctcctggttt      840

gtagatggga aacagatgca gaccgcaaaa actcaaccca gagaggagca gttcaacgga      900

acataccgag tggtatccgt ccttccgatt ggccaccagg actggttgaa agggaagcag      960

tttacgtgta aagtcaacaa taaggggttg cctagcccta ttgagcggac gatttcgaaa     1020

gctaggggac aggcccacca gccatcggtc tatgtccttc cgccttcccg cgaggagctc     1080

tcgaagaata cagtgagcct tacatgcctc attaaggatt tcttcccgcc tgatatcgac     1140

gtagagtggc aatcaaacgg tcaacaggag ccggaatcca agtatagaac cactccgccc     1200

cagcttgacg aggacggatc atactttttg tattcaaaac tgtcggtgga taagagccgg     1260

tggcagagag gtgacacctt catctgtgcg gtgatgcacg aagcactcca taatcactac     1320

acccaagaga gcctctcgca ttcccccgga aag                                  1353


<210>  62
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Ile Tyr Tyr Pro Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu 
    130                 135                 140                 


Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp 
            180                 185                 190         


Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr 
        195                 200                 205             


Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg 
    210                 215                 220                 


Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr 
        275                 280                 285             


Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln 
305                 310                 315                 320 


Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  63
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  63
gaaattcagc tggtgcagag cggcggcgat ctggtgaaac cgggcggcag cctgcgcctg       60

agctgcaaag cgagcggcta tacctttacc aactatggca tgaactgggt gcgccaggcg      120

ccgggcaaag gcctgcagtg gatgggctgg attaacacct ataccggcga accgacctat      180

gcggatgatt ttaaaggccg ctttaccttt agcctggata acgcgaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt atttttgcgc gcgccgcagc      300

atttattatc cgtattgggg ccagggcacc accctgaccg tgagcagcgc ttccacaacc      360

gcgccatcag tctttccgtt ggccccatca tgcgggtcga cgagcggatc gactgtggcc      420

ctggcgtgct tggtgtcggg atactttccc gaacccgtca cggtcagctg gaactccgga      480

tcgcttacga gcggtgtgca tacgttcccc tcggtcttgc aatcatcagg gctctactcg      540

ctgtcgagca tggtaacggt gccctcatcg aggtggccct ccgaaacgtt cacatgtaac      600

gtagcacatc cagcctccaa aaccaaggtg gataaacccg tgccgaaaag agagaatggg      660

cgggtgcctc gaccccctga ttgccccaag tgtccggctc cggaaatgct cggtggaccc      720

tcagtgttta tcttccctcc gaagcccaag gacactctgc tgatcgcgcg cactccagaa      780

gtaacatgtg tagtggtgga ccttgatccc gaggaccccg aagtccagat ctcctggttt      840

gtagatggga aacagatgca gaccgcaaaa actcaaccca gagaggagca gttcaacgga      900

acataccgag tggtatccgt ccttccgatt ggccaccagg actggttgaa agggaagcag      960

tttacgtgta aagtcaacaa taaggggttg cctagcccta ttgagcggac gatttcgaaa     1020

gctaggggac aggcccacca gccatcggtc tatgtccttc cgccttcccg cgaggagctc     1080

tcgaagaata cagtgagcct tacatgcctc attaaggatt tcttcccgcc tgatatcgac     1140

gtagagtggc aatcaaacgg tcaacaggag ccggaatcca agtatagaac cactccgccc     1200

cagcttgacg aggacggatc atactttttg tattcaaaac tgtcggtgga taagagccgg     1260

tggcagagag gtgacacctt catctgtgcg gtgatgcacg aagcactcca taatcactac     1320

acccaagaga gcctctcgca ttcccccgga aag                                  1353


<210>  64
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  64

Glu Ile Gln Leu Val Gln Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Ser Leu Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Ser Ile Tyr Tyr Pro Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu 
    130                 135                 140                 


Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp 
            180                 185                 190         


Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr 
        195                 200                 205             


Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg 
    210                 215                 220                 


Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr 
        275                 280                 285             


Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln 
305                 310                 315                 320 


Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  65
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  65
gaaattcagc tggtgcagag cggcggcgat ctggtgaaac cgggcggcag cgtgcgcctg       60

agctgcaaag cgagcggcta tacctttacc aactatggca tgaactgggt gaaacaggcg      120

ccgggcaaag gcctgcagtg gatgggctgg attaacacct ataccggcga accgacctat      180

gcggatgatt ttaaaggccg ctttaccttt agcctggata acgcgaaaaa caccgcgtat      240

ctgcagatta acagcctgcg cgcggaagat accgcggtgt atttttgcgc gcgccgcagc      300

atttattatc cgtattgggg ccagggcacc accctgaccg tgagcagcgc ttccacaacc      360

gcgccatcag tctttccgtt ggccccatca tgcgggtcga cgagcggatc gactgtggcc      420

ctggcgtgct tggtgtcggg atactttccc gaacccgtca cggtcagctg gaactccgga      480

tcgcttacga gcggtgtgca tacgttcccc tcggtcttgc aatcatcagg gctctactcg      540

ctgtcgagca tggtaacggt gccctcatcg aggtggccct ccgaaacgtt cacatgtaac      600

gtagcacatc cagcctccaa aaccaaggtg gataaacccg tgccgaaaag agagaatggg      660

cgggtgcctc gaccccctga ttgccccaag tgtccggctc cggaaatgct cggtggaccc      720

tcagtgttta tcttccctcc gaagcccaag gacactctgc tgatcgcgcg cactccagaa      780

gtaacatgtg tagtggtgga ccttgatccc gaggaccccg aagtccagat ctcctggttt      840

gtagatggga aacagatgca gaccgcaaaa actcaaccca gagaggagca gttcaacgga      900

acataccgag tggtatccgt ccttccgatt ggccaccagg actggttgaa agggaagcag      960

tttacgtgta aagtcaacaa taaggggttg cctagcccta ttgagcggac gatttcgaaa     1020

gctaggggac aggcccacca gccatcggtc tatgtccttc cgccttcccg cgaggagctc     1080

tcgaagaata cagtgagcct tacatgcctc attaaggatt tcttcccgcc tgatatcgac     1140

gtagagtggc aatcaaacgg tcaacaggag ccggaatcca agtatagaac cactccgccc     1200

cagcttgacg aggacggatc atactttttg tattcaaaac tgtcggtgga taagagccgg     1260

tggcagagag gtgacacctt catctgtgcg gtgatgcacg aagcactcca taatcactac     1320

acccaagaga gcctctcgca ttcccccgga aag                                  1353


<210>  66
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  66

Glu Ile Gln Leu Val Gln Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Gln Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Ser Leu Asp Asn Ala Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Ser Ile Tyr Tyr Pro Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu 
    130                 135                 140                 


Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp 
            180                 185                 190         


Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr 
        195                 200                 205             


Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg 
    210                 215                 220                 


Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr 
        275                 280                 285             


Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln 
305                 310                 315                 320 


Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  67
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  67
gaagtgcagc tggtggaaag cggcggcgat ctggtgaaac cgggcggcag cctgcgcctg       60

agctgcgtgg cgagcggctt tacctttagc gattattata tgagctgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtggcgttt attcgcaaca aagcgaacgg ctataccacc      180

gaatatagcg cgagcctgaa aggccgcttt accattagcc gcgataacgc gaaaaacatg      240

gcgtatctgc agatgaacag cctgcgcgcg gaagataccg cggtgtatta ttgcgcgagc      300

tttggcctga tgtattattt tgattattgg ggccagggca ccaccctgac cgtgagcagc      360

gcttccacaa ccgcgccatc agtctttccg ttggccccat catgcgggtc gacgagcgga      420

tcgactgtgg ccctggcgtg cttggtgtcg ggatactttc ccgaacccgt cacggtcagc      480

tggaactccg gatcgcttac gagcggtgtg catacgttcc cctcggtctt gcaatcatca      540

gggctctact cgctgtcgag catggtaacg gtgccctcat cgaggtggcc ctccgaaacg      600

ttcacatgta acgtagcaca tccagcctcc aaaaccaagg tggataaacc cgtgccgaaa      660

agagagaatg ggcgggtgcc tcgaccccct gattgcccca agtgtccggc tccggaaatg      720

ctcggtggac cctcagtgtt tatcttccct ccgaagccca aggacactct gctgatcgcg      780

cgcactccag aagtaacatg tgtagtggtg gaccttgatc ccgaggaccc cgaagtccag      840

atctcctggt ttgtagatgg gaaacagatg cagaccgcaa aaactcaacc cagagaggag      900

cagttcaacg gaacataccg agtggtatcc gtccttccga ttggccacca ggactggttg      960

aaagggaagc agtttacgtg taaagtcaac aataaggggt tgcctagccc tattgagcgg     1020

acgatttcga aagctagggg acaggcccac cagccatcgg tctatgtcct tccgccttcc     1080

cgcgaggagc tctcgaagaa tacagtgagc cttacatgcc tcattaagga tttcttcccg     1140

cctgatatcg acgtagagtg gcaatcaaac ggtcaacagg agccggaatc caagtataga     1200

accactccgc cccagcttga cgaggacgga tcatactttt tgtattcaaa actgtcggtg     1260

gataagagcc ggtggcagag aggtgacacc ttcatctgtg cggtgatgca cgaagcactc     1320

cataatcact acacccaaga gagcctctcg cattcccccg gaaag                     1365


<210>  68
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Leu Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ser Phe Gly Leu Met Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala 
    130                 135                 140                 


Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly 
    210                 215                 220                 


Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu 
            260                 265                 270         


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        275                 280                 285             


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
305                 310                 315                 320 


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            340                 345                 350         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    370                 375                 380                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
385                 390                 395                 400 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            420                 425                 430         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210>  69
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  69
gaagtgcagc tggtggaaag cggcggcgat ctggtgaaac cgggcggcag cctgcgcctg       60

agctgcgcga ccagcggctt tacctttagc gattattata tgagctgggt gcgccaggcg      120

ccgggcaaag gcctggaatg gatgggcttt attcgcaaca aagcgaacgg ctataccacc      180

gaatatagcg cgagcctgaa aggccgcttt accattagcc gcgataacgc gaaaaacatg      240

gcgtatctgc agatgaacag cctgcgcgcg gaagataccg cggtgtatta ttgcgtgcgc      300

tttggcctga tgtattattt tgattattgg ggccagggca ccaccctgac cgtgagcagc      360

gcttccacaa ccgcgccatc agtctttccg ttggccccat catgcgggtc gacgagcgga      420

tcgactgtgg ccctggcgtg cttggtgtcg ggatactttc ccgaacccgt cacggtcagc      480

tggaactccg gatcgcttac gagcggtgtg catacgttcc cctcggtctt gcaatcatca      540

gggctctact cgctgtcgag catggtaacg gtgccctcat cgaggtggcc ctccgaaacg      600

ttcacatgta acgtagcaca tccagcctcc aaaaccaagg tggataaacc cgtgccgaaa      660

agagagaatg ggcgggtgcc tcgaccccct gattgcccca agtgtccggc tccggaaatg      720

ctcggtggac cctcagtgtt tatcttccct ccgaagccca aggacactct gctgatcgcg      780

cgcactccag aagtaacatg tgtagtggtg gaccttgatc ccgaggaccc cgaagtccag      840

atctcctggt ttgtagatgg gaaacagatg cagaccgcaa aaactcaacc cagagaggag      900

cagttcaacg gaacataccg agtggtatcc gtccttccga ttggccacca ggactggttg      960

aaagggaagc agtttacgtg taaagtcaac aataaggggt tgcctagccc tattgagcgg     1020

acgatttcga aagctagggg acaggcccac cagccatcgg tctatgtcct tccgccttcc     1080

cgcgaggagc tctcgaagaa tacagtgagc cttacatgcc tcattaagga tttcttcccg     1140

cctgatatcg acgtagagtg gcaatcaaac ggtcaacagg agccggaatc caagtataga     1200

accactccgc cccagcttga cgaggacgga tcatactttt tgtattcaaa actgtcggtg     1260

gataagagcc ggtggcagag aggtgacacc ttcatctgtg cggtgatgca cgaagcactc     1320

cataatcact acacccaaga gagcctctcg cattcccccg gaaag                     1365


<210>  70
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Leu Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg Phe Gly Leu Met Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala 
    130                 135                 140                 


Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly 
    210                 215                 220                 


Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu 
            260                 265                 270         


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        275                 280                 285             


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
305                 310                 315                 320 


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            340                 345                 350         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    370                 375                 380                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
385                 390                 395                 400 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            420                 425                 430         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210>  71
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  71
gaagtgaaac tggtggaaag cggcggcgat ctggtgaaac cgggcggcag cctgcgcctg       60

agctgcgcga ccagcggctt tacctttagc gattattata tgagctgggt gcgccaggcg      120

ccgggcaaag cgctggaatg gatgggcttt attcgcaaca aagcgaacgg ctataccacc      180

gaatatagcg cgagcctgaa aggccgcttt accattagcc gcgataacgc gaaaaacatg      240

ctgtatctgc agatgaacag cctgcgcgcg gaagataccg cggtgtatta ttgcgtgcgc      300

tttggcctga tgtattattt tgattattgg ggccagggca ccaccctgac cgtgagcagc      360

gcttccacaa ccgcgccatc agtctttccg ttggccccat catgcgggtc gacgagcgga      420

tcgactgtgg ccctggcgtg cttggtgtcg ggatactttc ccgaacccgt cacggtcagc      480

tggaactccg gatcgcttac gagcggtgtg catacgttcc cctcggtctt gcaatcatca      540

gggctctact cgctgtcgag catggtaacg gtgccctcat cgaggtggcc ctccgaaacg      600

ttcacatgta acgtagcaca tccagcctcc aaaaccaagg tggataaacc cgtgccgaaa      660

agagagaatg ggcgggtgcc tcgaccccct gattgcccca agtgtccggc tccggaaatg      720

ctcggtggac cctcagtgtt tatcttccct ccgaagccca aggacactct gctgatcgcg      780

cgcactccag aagtaacatg tgtagtggtg gaccttgatc ccgaggaccc cgaagtccag      840

atctcctggt ttgtagatgg gaaacagatg cagaccgcaa aaactcaacc cagagaggag      900

cagttcaacg gaacataccg agtggtatcc gtccttccga ttggccacca ggactggttg      960

aaagggaagc agtttacgtg taaagtcaac aataaggggt tgcctagccc tattgagcgg     1020

acgatttcga aagctagggg acaggcccac cagccatcgg tctatgtcct tccgccttcc     1080

cgcgaggagc tctcgaagaa tacagtgagc cttacatgcc tcattaagga tttcttcccg     1140

cctgatatcg acgtagagtg gcaatcaaac ggtcaacagg agccggaatc caagtataga     1200

accactccgc cccagcttga cgaggacgga tcatactttt tgtattcaaa actgtcggtg     1260

gataagagcc ggtggcagag aggtgacacc ttcatctgtg cggtgatgca cgaagcactc     1320

cataatcact acacccaaga gagcctctcg cattcccccg gaaag                     1365


<210>  72
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  72

Glu Val Lys Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Leu Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg Phe Gly Leu Met Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala 
    130                 135                 140                 


Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly 
    210                 215                 220                 


Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu 
            260                 265                 270         


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        275                 280                 285             


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
305                 310                 315                 320 


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            340                 345                 350         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    370                 375                 380                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
385                 390                 395                 400 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            420                 425                 430         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210>  73
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  73
gaagtgcagc tggtggaaag cggcggcgat ctggtgaaac cgggcggcag cctgcgcctg       60

agctgcgtgg cgagcggcta tacctttacc aactatggca tgaactgggt gcgccaggcg      120

ccgggcaaag gcctgcagtg ggtggcgtgg attaacacct ataccggcga accgacctat      180

gcggatgatt ttaaaggccg ctttaccatt agccgcgata acgcgaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgccgcagc      300

atttattatc cgtattgggg ccagggcacc accctgaccg tgagcagcgc ttccacaacc      360

gcgccatcag tctttccgtt ggccccatca tgcgggtcga cgagcggatc gactgtggcc      420

ctggcgtgct tggtgtcggg atactttccc gaacccgtca cggtcagctg gaactccgga      480

tcgcttacga gcggtgtgca tacgttcccc tcggtcttgc aatcatcagg gctctactcg      540

ctgtcgagca tggtaacggt gccctcatcg aggtggccct ccgaaacgtt cacatgtaac      600

gtagcacatc cagcctccaa aaccaaggtg gataaacccg tgccgaaaag agagaatggg      660

cgggtgcctc gaccccctga ttgccccaag tgtccggctc cggaaatgct cggtggaccc      720

tcagtgttta tcttccctcc gaagcccaag gacactctgc tgatcgcgcg cactccagaa      780

gtaacatgtg tagtggtggc tcttgatccc gaggaccccg aagtccagat ctcctggttt      840

gtagatggga aacagatgca gaccgcaaaa actcaaccca gagaggagca gttcgccgga      900

acataccgag tggtatccgt ccttccgatt ggccaccagg actggttgaa agggaagcag      960

tttacgtgta aagtcaacaa taaggggttg cctagcccta ttgagcggac gatttcgaaa     1020

gctaggggac aggcccacca gccatcggtc tatgtccttc cgccttcccg cgaggagctc     1080

tcgaagaata cagtgagcct tacatgcctc attaaggatt tcttcccgcc tgatatcgac     1140

gtagagtggc aatcaaacgg tcaacaggag ccggaatcca agtatagaac cactccgccc     1200

cagcttgacg aggacggatc atactttttg tattcaaaac tgtcggtgga taagagccgg     1260

tggcagagag gtgacacctt catctgtgcg gtgatgcacg aagcactcca taatcactac     1320

acccaagaga gcctctcgca ttcccccgga aag                                  1353


<210>  74
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Ile Tyr Tyr Pro Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu 
    130                 135                 140                 


Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp 
            180                 185                 190         


Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr 
        195                 200                 205             


Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg 
    210                 215                 220                 


Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu Asp Pro Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr 
        275                 280                 285             


Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln 
305                 310                 315                 320 


Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  75
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  75
gaaattcagc tggtgcagag cggcggcgat ctggtgaaac cgggcggcag cctgcgcctg       60

agctgcaaag cgagcggcta tacctttacc aactatggca tgaactgggt gcgccaggcg      120

ccgggcaaag gcctgcagtg gatgggctgg attaacacct ataccggcga accgacctat      180

gcggatgatt ttaaaggccg ctttaccttt agcctggata acgcgaaaaa caccctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt atttttgcgc gcgccgcagc      300

atttattatc cgtattgggg ccagggcacc accctgaccg tgagcagcgc ttccacaacc      360

gcgccatcag tctttccgtt ggccccatca tgcgggtcga cgagcggatc gactgtggcc      420

ctggcgtgct tggtgtcggg atactttccc gaacccgtca cggtcagctg gaactccgga      480

tcgcttacga gcggtgtgca tacgttcccc tcggtcttgc aatcatcagg gctctactcg      540

ctgtcgagca tggtaacggt gccctcatcg aggtggccct ccgaaacgtt cacatgtaac      600

gtagcacatc cagcctccaa aaccaaggtg gataaacccg tgccgaaaag agagaatggg      660

cgggtgcctc gaccccctga ttgccccaag tgtccggctc cggaaatgct cggtggaccc      720

tcagtgttta tcttccctcc gaagcccaag gacactctgc tgatcgcgcg cactccagaa      780

gtaacatgtg tagtggtggc tcttgatccc gaggaccccg aagtccagat ctcctggttt      840

gtagatggga aacagatgca gaccgcaaaa actcaaccca gagaggagca gttcgccgga      900

acataccgag tggtatccgt ccttccgatt ggccaccagg actggttgaa agggaagcag      960

tttacgtgta aagtcaacaa taaggggttg cctagcccta ttgagcggac gatttcgaaa     1020

gctaggggac aggcccacca gccatcggtc tatgtccttc cgccttcccg cgaggagctc     1080

tcgaagaata cagtgagcct tacatgcctc attaaggatt tcttcccgcc tgatatcgac     1140

gtagagtggc aatcaaacgg tcaacaggag ccggaatcca agtatagaac cactccgccc     1200

cagcttgacg aggacggatc atactttttg tattcaaaac tgtcggtgga taagagccgg     1260

tggcagagag gtgacacctt catctgtgcg gtgatgcacg aagcactcca taatcactac     1320

acccaagaga gcctctcgca ttcccccgga aag                                  1353


<210>  76
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  76

Glu Ile Gln Leu Val Gln Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Ser Leu Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Ser Ile Tyr Tyr Pro Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu 
    130                 135                 140                 


Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp 
            180                 185                 190         


Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr 
        195                 200                 205             


Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg 
    210                 215                 220                 


Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu Asp Pro Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr 
        275                 280                 285             


Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln 
305                 310                 315                 320 


Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  77
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  77
gaaattcagc tggtgcagag cggcggcgat ctggtgaaac cgggcggcag cgtgcgcctg       60

agctgcaaag cgagcggcta tacctttacc aactatggca tgaactgggt gaaacaggcg      120

ccgggcaaag gcctgcagtg gatgggctgg attaacacct ataccggcga accgacctat      180

gcggatgatt ttaaaggccg ctttaccttt agcctggata acgcgaaaaa caccgcgtat      240

ctgcagatta acagcctgcg cgcggaagat accgcggtgt atttttgcgc gcgccgcagc      300

atttattatc cgtattgggg ccagggcacc accctgaccg tgagcagcgc ttccacaacc      360

gcgccatcag tctttccgtt ggccccatca tgcgggtcga cgagcggatc gactgtggcc      420

ctggcgtgct tggtgtcggg atactttccc gaacccgtca cggtcagctg gaactccgga      480

tcgcttacga gcggtgtgca tacgttcccc tcggtcttgc aatcatcagg gctctactcg      540

ctgtcgagca tggtaacggt gccctcatcg aggtggccct ccgaaacgtt cacatgtaac      600

gtagcacatc cagcctccaa aaccaaggtg gataaacccg tgccgaaaag agagaatggg      660

cgggtgcctc gaccccctga ttgccccaag tgtccggctc cggaaatgct cggtggaccc      720

tcagtgttta tcttccctcc gaagcccaag gacactctgc tgatcgcgcg cactccagaa      780

gtaacatgtg tagtggtggc tcttgatccc gaggaccccg aagtccagat ctcctggttt      840

gtagatggga aacagatgca gaccgcaaaa actcaaccca gagaggagca gttcgccgga      900

acataccgag tggtatccgt ccttccgatt ggccaccagg actggttgaa agggaagcag      960

tttacgtgta aagtcaacaa taaggggttg cctagcccta ttgagcggac gatttcgaaa     1020

gctaggggac aggcccacca gccatcggtc tatgtccttc cgccttcccg cgaggagctc     1080

tcgaagaata cagtgagcct tacatgcctc attaaggatt tcttcccgcc tgatatcgac     1140

gtagagtggc aatcaaacgg tcaacaggag ccggaatcca agtatagaac cactccgccc     1200

cagcttgacg aggacggatc atactttttg tattcaaaac tgtcggtgga taagagccgg     1260

tggcagagag gtgacacctt catctgtgcg gtgatgcacg aagcactcca taatcactac     1320

acccaagaga gcctctcgca ttcccccgga aag                                  1353


<210>  78
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  78

Glu Ile Gln Leu Val Gln Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Gln Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Ser Leu Asp Asn Ala Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Ser Ile Tyr Tyr Pro Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu 
    130                 135                 140                 


Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp 
            180                 185                 190         


Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr 
        195                 200                 205             


Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg 
    210                 215                 220                 


Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu Asp Pro Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr 
        275                 280                 285             


Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln 
305                 310                 315                 320 


Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln 
    370                 375                 380                 


Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro 
385                 390                 395                 400 


Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  79
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  79
gaagtgcagc tggtggaaag cggcggcgat ctggtgaaac cgggcggcag cctgcgcctg       60

agctgcgtgg cgagcggctt tacctttagc gattattata tgagctgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtggcgttt attcgcaaca aagcgaacgg ctataccacc      180

gaatatagcg cgagcctgaa aggccgcttt accattagcc gcgataacgc gaaaaacatg      240

gcgtatctgc agatgaacag cctgcgcgcg gaagataccg cggtgtatta ttgcgcgagc      300

tttggcctga tgtattattt tgattattgg ggccagggca ccaccctgac cgtgagcagc      360

gcttccacaa ccgcgccatc agtctttccg ttggccccat catgcgggtc gacgagcgga      420

tcgactgtgg ccctggcgtg cttggtgtcg ggatactttc ccgaacccgt cacggtcagc      480

tggaactccg gatcgcttac gagcggtgtg catacgttcc cctcggtctt gcaatcatca      540

gggctctact cgctgtcgag catggtaacg gtgccctcat cgaggtggcc ctccgaaacg      600

ttcacatgta acgtagcaca tccagcctcc aaaaccaagg tggataaacc cgtgccgaaa      660

agagagaatg ggcgggtgcc tcgaccccct gattgcccca agtgtccggc tccggaaatg      720

ctcggtggac cctcagtgtt tatcttccct ccgaagccca aggacactct gctgatcgcg      780

cgcactccag aagtaacatg tgtagtggtg gctcttgatc ccgaggaccc cgaagtccag      840

atctcctggt ttgtagatgg gaaacagatg cagaccgcaa aaactcaacc cagagaggag      900

cagttcgccg gaacataccg agtggtatcc gtccttccga ttggccacca ggactggttg      960

aaagggaagc agtttacgtg taaagtcaac aataaggggt tgcctagccc tattgagcgg     1020

acgatttcga aagctagggg acaggcccac cagccatcgg tctatgtcct tccgccttcc     1080

cgcgaggagc tctcgaagaa tacagtgagc cttacatgcc tcattaagga tttcttcccg     1140

cctgatatcg acgtagagtg gcaatcaaac ggtcaacagg agccggaatc caagtataga     1200

accactccgc cccagcttga cgaggacgga tcatactttt tgtattcaaa actgtcggtg     1260

gataagagcc ggtggcagag aggtgacacc ttcatctgtg cggtgatgca cgaagcactc     1320

cataatcact acacccaaga gagcctctcg cattcccccg gaaag                     1365


<210>  80
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  80

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Leu Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ser Phe Gly Leu Met Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala 
    130                 135                 140                 


Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly 
    210                 215                 220                 


Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu 
            260                 265                 270         


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        275                 280                 285             


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
305                 310                 315                 320 


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            340                 345                 350         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    370                 375                 380                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
385                 390                 395                 400 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            420                 425                 430         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210>  81
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  81
gaagtgcagc tggtggaaag cggcggcgat ctggtgaaac cgggcggcag cctgcgcctg       60

agctgcgcga ccagcggctt tacctttagc gattattata tgagctgggt gcgccaggcg      120

ccgggcaaag gcctggaatg gatgggcttt attcgcaaca aagcgaacgg ctataccacc      180

gaatatagcg cgagcctgaa aggccgcttt accattagcc gcgataacgc gaaaaacatg      240

gcgtatctgc agatgaacag cctgcgcgcg gaagataccg cggtgtatta ttgcgtgcgc      300

tttggcctga tgtattattt tgattattgg ggccagggca ccaccctgac cgtgagcagc      360

gcttccacaa ccgcgccatc agtctttccg ttggccccat catgcgggtc gacgagcgga      420

tcgactgtgg ccctggcgtg cttggtgtcg ggatactttc ccgaacccgt cacggtcagc      480

tggaactccg gatcgcttac gagcggtgtg catacgttcc cctcggtctt gcaatcatca      540

gggctctact cgctgtcgag catggtaacg gtgccctcat cgaggtggcc ctccgaaacg      600

ttcacatgta acgtagcaca tccagcctcc aaaaccaagg tggataaacc cgtgccgaaa      660

agagagaatg ggcgggtgcc tcgaccccct gattgcccca agtgtccggc tccggaaatg      720

ctcggtggac cctcagtgtt tatcttccct ccgaagccca aggacactct gctgatcgcg      780

cgcactccag aagtaacatg tgtagtggtg gctcttgatc ccgaggaccc cgaagtccag      840

atctcctggt ttgtagatgg gaaacagatg cagaccgcaa aaactcaacc cagagaggag      900

cagttcgccg gaacataccg agtggtatcc gtccttccga ttggccacca ggactggttg      960

aaagggaagc agtttacgtg taaagtcaac aataaggggt tgcctagccc tattgagcgg     1020

acgatttcga aagctagggg acaggcccac cagccatcgg tctatgtcct tccgccttcc     1080

cgcgaggagc tctcgaagaa tacagtgagc cttacatgcc tcattaagga tttcttcccg     1140

cctgatatcg acgtagagtg gcaatcaaac ggtcaacagg agccggaatc caagtataga     1200

accactccgc cccagcttga cgaggacgga tcatactttt tgtattcaaa actgtcggtg     1260

gataagagcc ggtggcagag aggtgacacc ttcatctgtg cggtgatgca cgaagcactc     1320

cataatcact acacccaaga gagcctctcg cattcccccg gaaag                     1365


<210>  82
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  82

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Leu Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg Phe Gly Leu Met Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala 
    130                 135                 140                 


Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly 
    210                 215                 220                 


Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu 
            260                 265                 270         


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        275                 280                 285             


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
305                 310                 315                 320 


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            340                 345                 350         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    370                 375                 380                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
385                 390                 395                 400 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            420                 425                 430         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210>  83
<211>  1365
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  83
gaagtgaaac tggtggaaag cggcggcgat ctggtgaaac cgggcggcag cctgcgcctg       60

agctgcgcga ccagcggctt tacctttagc gattattata tgagctgggt gcgccaggcg      120

ccgggcaaag cgctggaatg gatgggcttt attcgcaaca aagcgaacgg ctataccacc      180

gaatatagcg cgagcctgaa aggccgcttt accattagcc gcgataacgc gaaaaacatg      240

ctgtatctgc agatgaacag cctgcgcgcg gaagataccg cggtgtatta ttgcgtgcgc      300

tttggcctga tgtattattt tgattattgg ggccagggca ccaccctgac cgtgagcagc      360

gcttccacaa ccgcgccatc agtctttccg ttggccccat catgcgggtc gacgagcgga      420

tcgactgtgg ccctggcgtg cttggtgtcg ggatactttc ccgaacccgt cacggtcagc      480

tggaactccg gatcgcttac gagcggtgtg catacgttcc cctcggtctt gcaatcatca      540

gggctctact cgctgtcgag catggtaacg gtgccctcat cgaggtggcc ctccgaaacg      600

ttcacatgta acgtagcaca tccagcctcc aaaaccaagg tggataaacc cgtgccgaaa      660

agagagaatg ggcgggtgcc tcgaccccct gattgcccca agtgtccggc tccggaaatg      720

ctcggtggac cctcagtgtt tatcttccct ccgaagccca aggacactct gctgatcgcg      780

cgcactccag aagtaacatg tgtagtggtg gctcttgatc ccgaggaccc cgaagtccag      840

atctcctggt ttgtagatgg gaaacagatg cagaccgcaa aaactcaacc cagagaggag      900

cagttcgccg gaacataccg agtggtatcc gtccttccga ttggccacca ggactggttg      960

aaagggaagc agtttacgtg taaagtcaac aataaggggt tgcctagccc tattgagcgg     1020

acgatttcga aagctagggg acaggcccac cagccatcgg tctatgtcct tccgccttcc     1080

cgcgaggagc tctcgaagaa tacagtgagc cttacatgcc tcattaagga tttcttcccg     1140

cctgatatcg acgtagagtg gcaatcaaac ggtcaacagg agccggaatc caagtataga     1200

accactccgc cccagcttga cgaggacgga tcatactttt tgtattcaaa actgtcggtg     1260

gataagagcc ggtggcagag aggtgacacc ttcatctgtg cggtgatgca cgaagcactc     1320

cataatcact acacccaaga gagcctctcg cattcccccg gaaag                     1365


<210>  84
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  caninized mus musculus

<400>  84

Glu Val Lys Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Met 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Leu Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg Phe Gly Leu Met Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val Ala 
    130                 135                 140                 


Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Met Val Thr Val Pro 
            180                 185                 190         


Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Lys Thr Lys Val Asp Lys Pro Val Pro Lys Arg Glu Asn Gly 
    210                 215                 220                 


Arg Val Pro Arg Pro Pro Asp Cys Pro Lys Cys Pro Ala Pro Glu Met 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu 
            260                 265                 270         


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        275                 280                 285             


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
305                 310                 315                 320 


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                325                 330                 335     


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            340                 345                 350         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    370                 375                 380                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
385                 390                 395                 400 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            420                 425                 430         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys 
    450                 455 


<210>  85
<211>  15
<212>  DNA
<213>  Mus musculus

<400>  85
aactatggaa tgaac                                                        15


<210>  86
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  86

Asn Tyr Gly Met Asn 
1               5   


<210>  87
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  87
tggataaaca cctacactgg agagccaaca tatgctgatg acttcaaggg a                51


<210>  88
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  88

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  89
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  89
cggtcaattt attacccgta c                                                 21


<210>  90
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  90

Arg Ser Ile Tyr Tyr Pro Tyr 
1               5           


<210>  91
<211>  48
<212>  DNA
<213>  Mus musculus

<400>  91
agatctagtc agagcattgt atatagtaat ggaaacacct atttagaa                    48


<210>  92
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  92

Arg Ser Ser Gln Ser Ile Val Tyr Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  93
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  93
aaagtttcca accgattttc t                                                 21


<210>  94
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  94

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  95
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  95
tttcaaggtt cacatgttcc gtggacg                                           27


<210>  96
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  96

Phe Gln Gly Ser His Val Pro Trp Thr 
1               5                   


<210>  97
<211>  15
<212>  DNA
<213>  Mus musculus

<400>  97
gattactaca tgagc                                                        15


<210>  98
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  98

Asp Tyr Tyr Met Ser 
1               5   


<210>  99
<211>  57
<212>  DNA
<213>  Mus musculus

<400>  99
tttattagaa acaaagctaa tggttacaca acagagtaca gcgcatctct gaagggt          57


<210>  100
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  100

Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala Ser 
1               5                   10                  15      


Leu Lys Gly 
            


<210>  101
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  101
tttgggttaa tgtactactt tgactac                                           27


<210>  102
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  102

Phe Gly Leu Met Tyr Tyr Phe Asp Tyr 
1               5                   


<210>  103
<211>  36
<212>  DNA
<213>  Mus musculus

<400>  103
agggccagct caagtgtaag ttccagttac ttgcac                                 36


<210>  104
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  104

Arg Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His 
1               5                   10          


<210>  105
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  105
agcacatcca acttggcttc t                                                 21


<210>  106
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  106

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  107
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  107
cagcagtaca gtggtctccc actcacg                                           27


<210>  108
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  108

Gln Gln Tyr Ser Gly Leu Pro Leu Thr 
1               5                   


<210>  109
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  109

Thr Tyr Gly Val Ser 
1               5   


<210>  110
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  110

Ser Tyr Trp Met His 
1               5   


<210>  111
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  111

Trp Ile Asn Thr Tyr Ser Gly Met Pro Thr Tyr Val Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  112
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  112

Asn Ile Asn Pro Ser Asn Gly Gly Thr Arg Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asn 
    


<210>  113
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  113

Arg Gly Thr Tyr Tyr Arg Pro 
1               5           


<210>  114
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  114

Arg Gly Ile Ser Phe Asp Tyr 
1               5           


<210>  115
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  115

Arg Gly Val Arg Leu Asp Tyr 
1               5           


<210>  116
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  116

Ser Asn Tyr Gly Ser Gly Trp Ala Trp Phe Ala Tyr 
1               5                   10          


<210>  117
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  117

Arg Ser Ser Gln Ser Ile Val Tyr Ser His Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  118
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  118

Lys Ser Ser Gln Ser Ile Val Tyr Ile Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  119
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  119

Arg Ser Ser Gln Ser Ile Val Tyr Ile Ser Gly Ser Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  120
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  120

His Ala Ser Gln Asn Ile Asn Val Trp Leu Ser 
1               5                   10      


<210>  121
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  121

Lys Val Ser Lys Arg Phe Ser 
1               5           


<210>  122
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  122

Lys Val Ser Ser Arg Phe Ser 
1               5           


<210>  123
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  123

Lys Ser Ser Asn Leu His Thr 
1               5           


<210>  124
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  124

Gln Gln Gly Gln Ser Tyr Pro Trp Thr 
1               5                   


<210>  125
<211>  669
<212>  DNA
<213>  Canis familiaris

<400>  125
atggcgggct ttggctttcg ccgccatggc gcgcagccgg atctggcgag ccgcacctgg       60

ccgtgcaccg cgctgtttag cctgctgttt attccggtgt ttagcaaagg catgcatgtg      120

gcgcagccgg cggtggtgct ggcgagcagc cgcggcgtgg cgagctttgt gtgcgaatat      180

ggcagcagcg gcaacgcggc ggaagtgcgc gtgaccgtgc tgcgccaggc gggcagccag      240

atgaccgaag tgtgcgcggc gacctatacc gtggaagatg aactggcgtt tctggatgat      300

agcacctgca ccggcaccag cagcggcaac aaagtgaacc tgaccattca gggcctgcgc      360

gcgatggata ccggcctgta tatttgcaaa gtggaactga tgtatccgcc gccgtattat      420

gtgggcatgg gcaacggcac ccagatttat gtgattgatc cggaaccgtg cccggatagc      480

gattttctgc tgtggattct ggcggcggtg agcagcggcc tgttttttta tagctttctg      540

attaccgcgg tgagcctgag caaaatgctg aaaaaacgca gcccgctgac caccggcgtg      600

tatgtgaaaa tgccgccgac cgaaccggaa tgcgaaaaac agtttcagcc gtattttatt      660

ccgattaac                                                              669


<210>  126
<211>  223
<212>  PRT
<213>  Canis familiaris

<400>  126

Met Ala Gly Phe Gly Phe Arg Arg His Gly Ala Gln Pro Asp Leu Ala 
1               5                   10                  15      


Ser Arg Thr Trp Pro Cys Thr Ala Leu Phe Ser Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Ser Lys Gly Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Val Ala Ser Phe Val Cys Glu Tyr Gly Ser Ser Gly 
    50                  55                  60                  


Asn Ala Ala Glu Val Arg Val Thr Val Leu Arg Gln Ala Gly Ser Gln 
65                  70                  75                  80  


Met Thr Glu Val Cys Ala Ala Thr Tyr Thr Val Glu Asp Glu Leu Ala 
                85                  90                  95      


Phe Leu Asp Asp Ser Thr Cys Thr Gly Thr Ser Ser Gly Asn Lys Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Val Gly Met Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Ile Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210>  127
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  genetically modified canis familiaris

<400>  127

Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr 
1               5                   10                  15      


Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Leu 
            20                  25                  30          


Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys 
        35                  40                  45              


Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Ala Gly 
    50                  55                  60                  


Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu 
65                  70                  75                  80  


Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser 
                85                  90                  95      


Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro 
            100                 105                 110         


Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr 
        115                 120                 125             


Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp 
    130                 135                 140                 


Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg 
145                 150                 155                 160 


Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser 
                165                 170                 175     


Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile 
            180                 185                 190         


Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Glu Ser 
        195                 200                 205             


Leu Ser His Ser Pro Gly Lys 
    210                 215 


<210>  128
<211>  17
<212>  PRT
<213>  Canis familiaris

<400>  128

Phe Asn Glu Cys Arg Cys Thr Asp Thr Pro Pro Cys Pro Val Pro Glu 
1               5                   10                  15      


Pro 
    


<210>  129
<211>  22
<212>  PRT
<213>  Canis familiaris

<400>  129

Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Ala Pro Glu Met 
            20          


<210>  130
<211>  20
<212>  PRT
<213>  Canis familiaris

<400>  130

Ala Lys Glu Cys Glu Cys Lys Cys Asn Cys Asn Asn Cys Pro Cys Pro 
1               5                   10                  15      


Gly Cys Gly Leu 
            20  


<210>  131
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  genetically modified canis familiarus

<400>  131

Pro Lys Glu Ser Thr Cys Lys Cys Ile Pro Pro Cys Pro Val Pro Glu 
1               5                   10                  15      


Ser 
    


<210>  132
<211>  31
<212>  PRT
<213>  Canis familiaris

<400>  132

Ala Glu Val Arg Val Thr Val Leu Arg Gln Ala Gly Ser Gln Met Thr 
1               5                   10                  15      


Glu Val Cys Ala Ala Thr Tyr Thr Val Glu Asp Glu Leu Ala Phe 
            20                  25                  30      


<210>  133
<211>  21
<212>  PRT
<213>  Canis familiaris

<400>  133

Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Val Gly 
1               5                   10                  15      


Met Gly Asn Gly Thr 
            20      


<210>  134
<211>  8
<212>  PRT
<213>  Canis familiaris

<400>  134

Thr Val Leu Arg Gln Ala Gly Ser 
1               5               


<210>  135
<211>  5
<212>  PRT
<213>  Canis familiaris

<400>  135

Ala Thr Tyr Thr Val 
1               5   


<210>  136
<211>  13
<212>  PRT
<213>  Canis familiaris

<400>  136

Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr 
1               5                   10              


<210>  137
<211>  6
<212>  PRT
<213>  Canis familiaris

<400>  137

Met Tyr Pro Pro Pro Tyr 
1               5       


<210>  138
<211>  186
<212>  PRT
<213>  Canis familiaris

<400>  138

Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Val 
1               5                   10                  15      


Ala Ser Phe Val Cys Glu Tyr Gly Ser Ser Gly Asn Ala Ala Glu Val 
            20                  25                  30          


Arg Val Thr Val Leu Arg Gln Ala Gly Ser Gln Met Thr Glu Val Cys 
        35                  40                  45              


Ala Ala Thr Tyr Thr Val Glu Asp Glu Leu Ala Phe Leu Asp Asp Ser 
    50                  55                  60                  


Thr Cys Thr Gly Thr Ser Ser Gly Asn Lys Val Asn Leu Thr Ile Gln 
65                  70                  75                  80  


Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu 
                85                  90                  95      


Met Tyr Pro Pro Pro Tyr Tyr Val Gly Met Gly Asn Gly Thr Gln Ile 
            100                 105                 110         


Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Phe Leu Leu Trp 
        115                 120                 125             


Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe Tyr Ser Phe Leu Ile 
    130                 135                 140                 


Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys Arg Ser Pro Leu Thr 
145                 150                 155                 160 


Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu Pro Glu Cys Glu Lys 
                165                 170                 175     


Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
            180                 185     


