SEQUENCE LISTING

<110>   Janssen Pharmaceutica NV

<120>   BINDING AGENTS AND USES THEREOF

<130>   P078559WO

<140>
<141>   2020-07-10

<150>	EP19186059.2
<151>	2019-07-12

<160>   17

<170>   SeqWin2010, version 1.0

<210>   1
<211>   484
<212>   PRT
<213>   Homo sapiens 

<400>   1
Met Gly Ser Ala Phe Glu Arg Val Val Arg Arg Val Val Gln Glu Leu 
1               5                   10                  15      

Asp His Gly Gly Glu Phe Ile Pro Val Thr Ser Leu Gln Ser Ser Thr 
            20                  25                  30          

Gly Phe Gln Pro Tyr Cys Leu Val Val Arg Lys Pro Ser Ser Ser Trp 
        35                  40                  45              

Phe Trp Lys Pro Arg Tyr Lys Cys Val Asn Leu Ser Ile Lys Asp Ile 
    50                  55                  60                  

Leu Glu Pro Asp Ala Ala Glu Pro Asp Val Gln Arg Gly Arg Ser Phe 
65                  70                  75                  80  

His Phe Tyr Asp Ala Met Asp Gly Gln Ile Gln Gly Ser Val Glu Leu 
                85                  90                  95      

Ala Ala Pro Gly Gln Ala Lys Ile Ala Gly Gly Ala Ala Val Ser Asp 
            100                 105                 110         

Ser Ser Ser Thr Ser Met Asn Val Tyr Ser Leu Ser Val Asp Pro Asn 
        115                 120                 125             

Thr Trp Gln Thr Leu Leu His Glu Arg His Leu Arg Gln Pro Glu His 
    130                 135                 140                 

Lys Val Leu Gln Gln Leu Arg Ser Arg Gly Asp Asn Val Tyr Val Val 
145                 150                 155                 160 

Thr Glu Val Leu Gln Thr Gln Lys Glu Val Glu Val Thr Arg Thr His 
                165                 170                 175     

Lys Arg Glu Gly Ser Gly Arg Phe Ser Leu Pro Gly Ala Thr Cys Leu 
            180                 185                 190         

Gln Gly Glu Gly Gln Gly His Leu Ser Gln Lys Lys Thr Val Thr Ile 
        195                 200                 205             

Pro Ser Gly Ser Thr Leu Ala Phe Arg Val Ala Gln Leu Val Ile Asp 
    210                 215                 220                 

Ser Asp Leu Asp Val Leu Leu Phe Pro Asp Lys Lys Gln Arg Thr Phe 
225                 230                 235                 240 

Gln Pro Pro Ala Thr Gly His Lys Arg Ser Thr Ser Glu Gly Ala Trp 
                245                 250                 255     

Pro Gln Leu Pro Ser Gly Leu Ser Met Met Arg Cys Leu His Asn Phe 
            260                 265                 270         

Leu Thr Asp Gly Val Pro Ala Glu Gly Ala Phe Thr Glu Asp Phe Gln 
        275                 280                 285             

Gly Leu Arg Ala Glu Val Glu Thr Ile Ser Lys Glu Leu Glu Leu Leu 
    290                 295                 300                 

Asp Arg Glu Leu Cys Gln Leu Leu Leu Glu Gly Leu Glu Gly Val Leu 
305                 310                 315                 320 

Arg Asp Gln Leu Ala Leu Arg Ala Leu Glu Glu Ala Leu Glu Gln Gly 
                325                 330                 335     

Gln Ser Leu Gly Pro Val Glu Pro Leu Asp Gly Pro Ala Gly Ala Val 
            340                 345                 350         

Leu Glu Cys Leu Val Leu Ser Ser Gly Met Leu Val Pro Glu Leu Ala 
        355                 360                 365             

Ile Pro Val Val Tyr Leu Leu Gly Ala Leu Thr Met Leu Ser Glu Thr 
    370                 375                 380                 

Gln His Lys Leu Leu Ala Glu Ala Leu Glu Ser Gln Thr Leu Leu Gly 
385                 390                 395                 400 

Pro Leu Glu Leu Val Gly Ser Leu Leu Glu Gln Ser Ala Pro Trp Gln 
                405                 410                 415     

Glu Arg Ser Thr Met Ser Leu Pro Pro Gly Leu Leu Gly Asn Ser Trp 
            420                 425                 430         

Gly Glu Gly Ala Pro Ala Trp Val Leu Leu Asp Glu Cys Gly Leu Glu 
        435                 440                 445             

Leu Gly Glu Asp Thr Pro His Val Cys Trp Glu Pro Gln Ala Gln Gly 
    450                 455                 460                 

Arg Met Cys Ala Leu Tyr Ala Ser Leu Ala Leu Leu Ser Gly Leu Ser 
465                 470                 475                 480 

Gln Glu Pro His 
                

<210>   2
<211>   275
<212>   PRT
<213>   Homo sapiens

<400>   2
Met Gly Ser Ala Phe Glu Arg Val Val Arg Arg Val Val Gln Glu Leu 
1               5                   10                  15      

Asp His Gly Gly Glu Phe Ile Pro Val Thr Ser Leu Gln Ser Ser Thr 
            20                  25                  30          

Gly Phe Gln Pro Tyr Cys Leu Val Val Arg Lys Pro Ser Ser Ser Trp 
        35                  40                  45              

Phe Trp Lys Pro Arg Tyr Lys Cys Val Asn Leu Ser Ile Lys Asp Ile 
    50                  55                  60                  

Leu Glu Pro Asp Ala Ala Glu Pro Asp Val Gln Arg Gly Arg Ser Phe 
65                  70                  75                  80  

His Phe Tyr Asp Ala Met Asp Gly Gln Ile Gln Gly Ser Val Glu Leu 
                85                  90                  95      

Ala Ala Pro Gly Gln Ala Lys Ile Ala Gly Gly Ala Ala Val Ser Asp 
            100                 105                 110         

Ser Ser Ser Thr Ser Met Asn Val Tyr Ser Leu Ser Val Asp Pro Asn 
        115                 120                 125             

Thr Trp Gln Thr Leu Leu His Glu Arg His Leu Arg Gln Pro Glu His 
    130                 135                 140                 

Lys Val Leu Gln Gln Leu Arg Ser Arg Gly Asp Asn Val Tyr Val Val 
145                 150                 155                 160 

Thr Glu Val Leu Gln Thr Gln Lys Glu Val Glu Val Thr Arg Thr His 
                165                 170                 175     

Lys Arg Glu Gly Ser Gly Arg Phe Ser Leu Pro Gly Ala Thr Cys Leu 
            180                 185                 190         

Gln Gly Glu Gly Gln Gly His Leu Ser Gln Lys Lys Thr Val Thr Ile 
        195                 200                 205             

Pro Ser Gly Ser Thr Leu Ala Phe Arg Val Ala Gln Leu Val Ile Asp 
    210                 215                 220                 

Ser Asp Leu Asp Val Leu Leu Phe Pro Asp Lys Lys Gln Arg Thr Phe 
225                 230                 235                 240 

Gln Pro Pro Ala Thr Gly His Lys Arg Ser Thr Ser Glu Gly Ala Trp 
                245                 250                 255     

Pro Gln Leu Pro Ser Gly Leu Ser Met Met Arg Cys Leu His Asn Phe 
            260                 265                 270         

Leu Thr Asp 
        275 

<210>   3
<211>   209
<212>   PRT
<213>   Homo sapiens

<400>   3
Gly Val Pro Ala Glu Gly Ala Phe Thr Glu Asp Phe Gln Gly Leu Arg 
1               5                   10                  15      

Ala Glu Val Glu Thr Ile Ser Lys Glu Leu Glu Leu Leu Asp Arg Glu 
            20                  25                  30          

Leu Cys Gln Leu Leu Leu Glu Gly Leu Glu Gly Val Leu Arg Asp Gln 
        35                  40                  45              

Leu Ala Leu Arg Ala Leu Glu Glu Ala Leu Glu Gln Gly Gln Ser Leu 
    50                  55                  60                  

Gly Pro Val Glu Pro Leu Asp Gly Pro Ala Gly Ala Val Leu Glu Cys 
65                  70                  75                  80  

Leu Val Leu Ser Ser Gly Met Leu Val Pro Glu Leu Ala Ile Pro Val 
                85                  90                  95      

Val Tyr Leu Leu Gly Ala Leu Thr Met Leu Ser Glu Thr Gln His Lys 
            100                 105                 110         

Leu Leu Ala Glu Ala Leu Glu Ser Gln Thr Leu Leu Gly Pro Leu Glu 
        115                 120                 125             

Leu Val Gly Ser Leu Leu Glu Gln Ser Ala Pro Trp Gln Glu Arg Ser 
    130                 135                 140                 

Thr Met Ser Leu Pro Pro Gly Leu Leu Gly Asn Ser Trp Gly Glu Gly 
145                 150                 155                 160 

Ala Pro Ala Trp Val Leu Leu Asp Glu Cys Gly Leu Glu Leu Gly Glu 
                165                 170                 175     

Asp Thr Pro His Val Cys Trp Glu Pro Gln Ala Gln Gly Arg Met Cys 
            180                 185                 190         

Ala Leu Tyr Ala Ser Leu Ala Leu Leu Ser Gly Leu Ser Gln Glu Pro 
        195                 200                 205             

His 
    

<210>   4
<211>   115
<212>   PRT
<213>   Homo sapiens

<400>   4
Pro Asn Thr Trp Gln Thr Leu Leu His Glu Arg His Leu Arg Gln Pro 
1               5                   10                  15      

Glu His Lys Val Leu Gln Gln Leu Arg Ser Arg Gly Asp Asn Val Tyr 
            20                  25                  30          

Val Val Thr Glu Val Leu Gln Thr Gln Lys Glu Val Glu Val Thr Arg 
        35                  40                  45              

Thr His Lys Arg Glu Gly Ser Gly Arg Phe Ser Leu Pro Gly Ala Thr 
    50                  55                  60                  

Cys Leu Gln Gly Glu Gly Gln Gly His Leu Ser Gln Lys Lys Thr Val 
65                  70                  75                  80  

Thr Ile Pro Ser Gly Ser Thr Leu Ala Phe Arg Val Ala Gln Leu Val 
                85                  90                  95      

Ile Asp Ser Asp Leu Asp Val Leu Leu Phe Pro Asp Lys Lys Gln Arg 
            100                 105                 110         

Thr Phe Gln 
        115 

<210>   5
<211>   95
<212>   PRT
<213>   Homo sapiens

<400>   5
Arg His Leu Arg Gln Pro Glu His Lys Val Leu Gln Gln Leu Arg Ser 
1               5                   10                  15      

Arg Gly Asp Asn Val Tyr Val Val Thr Glu Val Leu Gln Thr Gln Lys 
            20                  25                  30          

Glu Val Glu Val Thr Arg Thr His Lys Arg Glu Gly Ser Gly Arg Phe 
        35                  40                  45              

Ser Leu Pro Gly Ala Thr Cys Leu Gln Gly Glu Gly Gln Gly His Leu 
    50                  55                  60                  

Ser Gln Lys Lys Thr Val Thr Ile Pro Ser Gly Ser Thr Leu Ala Phe 
65                  70                  75                  80  

Arg Val Ala Gln Leu Val Ile Asp Ser Asp Leu Asp Val Leu Leu 
                85                  90                  95  

<210>   6
<211>   75
<212>   PRT
<213>   Homo sapiens

<400>   6
Leu Gln Gln Leu Arg Ser Arg Gly Asp Asn Val Tyr Val Val Thr Glu 
1               5                   10                  15      

Val Leu Gln Thr Gln Lys Glu Val Glu Val Thr Arg Thr His Lys Arg 
            20                  25                  30          

Glu Gly Ser Gly Arg Phe Ser Leu Pro Gly Ala Thr Cys Leu Gln Gly 
        35                  40                  45              

Glu Gly Gln Gly His Leu Ser Gln Lys Lys Thr Val Thr Ile Pro Ser 
    50                  55                  60                  

Gly Ser Thr Leu Ala Phe Arg Val Ala Gln Leu 
65                  70                  75  

<210>   7
<211>   55
<212>   PRT
<213>   Homo sapiens

<400>   7
Val Tyr Val Val Thr Glu Val Leu Gln Thr Gln Lys Glu Val Glu Val 
1               5                   10                  15      

Thr Arg Thr His Lys Arg Glu Gly Ser Gly Arg Phe Ser Leu Pro Gly 
            20                  25                  30          

Ala Thr Cys Leu Gln Gly Glu Gly Gln Gly His Leu Ser Gln Lys Lys 
        35                  40                  45              

Thr Val Thr Ile Pro Ser Gly 
    50                  55  

<210>   8
<211>   35
<212>   PRT
<213>   Homo sapiens

<400>   8
Gln Lys Glu Val Glu Val Thr Arg Thr His Lys Arg Glu Gly Ser Gly 
1               5                   10                  15      

Arg Phe Ser Leu Pro Gly Ala Thr Cys Leu Gln Gly Glu Gly Gln Gly 
            20                  25                  30          

His Leu Ser 
        35  

<210>   9
<211>   15
<212>   PRT
<213>   Homo sapiens

<400>   9
Lys Arg Glu Gly Ser Gly Arg Phe Ser Leu Pro Gly Ala Thr Cys 
1               5                   10                  15  

<210>   10
<211>   13
<212>   PRT
<213>   Homo sapiens

<400>   10
Glu His Lys Val Leu Gln Gln Leu Arg Ser Arg Gly Asp 
1               5                   10              

<210>   11
<211>   14
<212>   PRT
<213>   Homo sapiens

<400>   11
Ala Phe Glu Arg Val Val Arg Arg Val Val Gln Glu Leu Asp 
1               5                   10                  

<210>   12
<211>   6
<212>   PRT
<213>   Homo sapiens

<400>   12
Tyr Cys Leu Val Val Arg 
1               5       

<210>   13
<211>   7
<212>   PRT
<213>   Homo sapiens

<400>   13
Tyr Lys Cys Val Asn Leu Ser 
1               5           

<210>   14
<211>   7
<212>   PRT
<213>   Homo sapiens

<400>   14
Met Asp Gly Gln Ile Gln Gly 
1               5           

<210>   15
<211>   10
<212>   PRT
<213>   Homo sapiens

<400>   15
Pro Asn Thr Trp Gln Thr Leu Leu His Glu 
1               5                   10  

<210>   16
<211>   4
<212>   PRT
<213>   Homo sapiens

<400>   16
Asp Leu Asp Val 
1               

<210>   17
<211>   15
<212>   PRT
<213>   Mus musculus

<400>   17
Ser Gln Glu Gly Ser Gly Gln Phe Thr Leu Pro Gly Ala Leu Cys 
1               5                   10                  15  

