               SEQUENCE LISTING

<110> Deutsches Zentrum für Neurodegenerative Erkrankungen e. V. (DZNE)

<120> NMDA RECEPTOR CONSTRUCTS TO DETECT AND ISOLATE NMDAR AUTOANTIBODIES

<130> 2212/19WO

<150> LU101308
<151> 2019-07-18
<150> EP19186524.5
<151> 2019-07-16

<160> 101

<170> BiSSAP 1.3.6

<210> 1
<211> 631
<212> PRT
<213> Artificial Sequence


<220> 
<223> protein sequence of fusion protein #1 N1-ATD-Fc

<400> 1
Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      
Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          
Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              
Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  
Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  
Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      
Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         
Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             
Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 
Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 
Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     
Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu 
            180                 185                 190         
Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu 
        195                 200                 205             
Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser 
    210                 215                 220                 
Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met 
225                 230                 235                 240 
Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly 
                245                 250                 255     
Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile 
            260                 265                 270         
Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val 
        275                 280                 285             
Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro 
    290                 295                 300                 
Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu 
305                 310                 315                 320 
Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly 
                325                 330                 335     
Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser 
            340                 345                 350         
Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn 
        355                 360                 365             
Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly 
    370                 375                 380                 
Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile 
385                 390                 395                 400 
Gly Ser Ser Thr Met Val Arg Ser Ser Lys Pro Thr Cys Pro Pro Pro 
                405                 410                 415     
Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
            420                 425                 430         
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        435                 440                 445             
Asp Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn 
    450                 455                 460                 
Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe 
465                 470                 475                 480 
Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Ala His Gln Asp 
                485                 490                 495     
Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu 
            500                 505                 510         
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu 
        515                 520                 525             
Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser 
    530                 535                 540                 
Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp 
545                 550                 555                 560 
Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys 
                565                 570                 575     
Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser 
            580                 585                 590         
Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr 
        595                 600                 605             
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    610                 615                 620                 
Ile Ser Arg Ser Pro Gly Lys 
625                 630     

<210> 2
<211> 400
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino terminal domain (ATD) of GluN1 including the signal
      sequence as in fusion protein #1

<400> 2
Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      
Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          
Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              
Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  
Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  
Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      
Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         
Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             
Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 
Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 
Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     
Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu 
            180                 185                 190         
Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu 
        195                 200                 205             
Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser 
    210                 215                 220                 
Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met 
225                 230                 235                 240 
Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly 
                245                 250                 255     
Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile 
            260                 265                 270         
Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val 
        275                 280                 285             
Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro 
    290                 295                 300                 
Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu 
305                 310                 315                 320 
Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly 
                325                 330                 335     
Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser 
            340                 345                 350         
Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn 
        355                 360                 365             
Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly 
    370                 375                 380                 
Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile 
385                 390                 395                 400 



<210> 3
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker between NMDAR domain and rabbit Fc to be used in fusion
      proteins of NMDAR protein constructs of the invention

<400> 3
Gly Ser Ser Thr Met Val Arg Ser 
1               5               

<210> 4
<211> 223
<212> PRT
<213> Artificial Sequence


<220> 
<223> Rabbit Fc from Vector pFuse-rIgG-Fc1

<400> 4
Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      
Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Asp Asp Pro Glu 
        35                  40                  45              
Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg 
    50                  55                  60                  
Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg Val Val Ser 
65                  70                  75                  80  
Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys 
                85                  90                  95      
Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         
Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly 
        115                 120                 125             
Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met 
    130                 135                 140                 
Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn 
145                 150                 155                 160 
Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser 
                165                 170                 175     
Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Pro Thr Ser Glu 
            180                 185                 190         
Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             
His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys 
    210                 215                 220             

<210> 5
<211> 376
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN1 in NM_007327 with domain borders
      as in cd06379: PBP1_iGluR_NMDA_NR1 (NCBI)

<400> 5
Thr Leu Ala Leu Leu Phe Ser Cys Ser Val Ala Arg Ala Ala Cys Asp 
1               5                   10                  15      
Pro Lys Ile Val Asn Ile Gly Ala Val Leu Ser Thr Arg Lys His Glu 
            20                  25                  30          
Gln Met Phe Arg Glu Ala Val Asn Gln Ala Asn Lys Arg His Gly Ser 
        35                  40                  45              
Trp Lys Ile Gln Leu Asn Ala Thr Ser Val Thr His Lys Pro Asn Ala 
    50                  55                  60                  
Ile Gln Met Ala Leu Ser Val Cys Glu Asp Leu Ile Ser Ser Gln Val 
65                  70                  75                  80  
Tyr Ala Ile Leu Val Ser His Pro Pro Thr Pro Asn Asp His Phe Thr 
                85                  90                  95      
Pro Thr Pro Val Ser Tyr Thr Ala Gly Phe Tyr Arg Ile Pro Val Leu 
            100                 105                 110         
Gly Leu Thr Thr Arg Met Ser Ile Tyr Ser Asp Lys Ser Ile His Leu 
        115                 120                 125             
Ser Phe Leu Arg Thr Val Pro Pro Tyr Ser His Gln Ser Ser Val Trp 
    130                 135                 140                 
Phe Glu Met Met Arg Val Tyr Ser Trp Asn His Ile Ile Leu Leu Val 
145                 150                 155                 160 
Ser Asp Asp His Glu Gly Arg Ala Ala Gln Lys Arg Leu Glu Thr Leu 
                165                 170                 175     
Leu Glu Glu Arg Glu Ser Lys Ala Glu Lys Val Leu Gln Phe Asp Pro 
            180                 185                 190         
Gly Thr Lys Asn Val Thr Ala Leu Leu Met Glu Ala Lys Glu Leu Glu 
        195                 200                 205             
Ala Arg Val Ile Ile Leu Ser Ala Ser Glu Asp Asp Ala Ala Thr Val 
    210                 215                 220                 
Tyr Arg Ala Ala Ala Met Leu Asn Met Thr Gly Ser Gly Tyr Val Trp 
225                 230                 235                 240 
Leu Val Gly Glu Arg Glu Ile Ser Gly Asn Ala Leu Arg Tyr Ala Pro 
                245                 250                 255     
Asp Gly Ile Leu Gly Leu Gln Leu Ile Asn Gly Lys Asn Glu Ser Ala 
            260                 265                 270         
His Ile Ser Asp Ala Val Gly Val Val Ala Gln Ala Val His Glu Leu 
        275                 280                 285             
Leu Glu Lys Glu Asn Ile Thr Asp Pro Pro Arg Gly Cys Val Gly Asn 
    290                 295                 300                 
Thr Asn Ile Trp Lys Thr Gly Pro Leu Phe Lys Arg Val Leu Met Ser 
305                 310                 315                 320 
Ser Lys Tyr Ala Asp Gly Val Thr Gly Arg Val Glu Phe Asn Glu Asp 
                325                 330                 335     
Gly Asp Arg Lys Phe Ala Asn Tyr Ser Ile Met Asn Leu Gln Asn Arg 
            340                 345                 350         
Lys Leu Val Gln Val Gly Ile Tyr Asn Gly Thr His Val Ile Pro Asn 
        355                 360                 365             
Asp Arg Lys Ile Ile Trp Pro Gly 
    370                 375     

<210> 6
<211> 915
<212> PRT
<213> Artificial Sequence


<220> 
<223> protein seq of fusion protein #2 N1ecd-Fc

<400> 6
Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      
Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          
Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              
Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  
Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  
Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      
Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         
Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             
Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 
Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 
Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     
Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu 
            180                 185                 190         
Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu 
        195                 200                 205             
Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser 
    210                 215                 220                 
Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met 
225                 230                 235                 240 
Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly 
                245                 250                 255     
Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile 
            260                 265                 270         
Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val 
        275                 280                 285             
Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro 
    290                 295                 300                 
Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu 
305                 310                 315                 320 
Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly 
                325                 330                 335     
Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser 
            340                 345                 350         
Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn 
        355                 360                 365             
Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly 
    370                 375                 380                 
Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile 
385                 390                 395                 400 
Val Thr Ile His Gln Glu Pro Phe Val Tyr Val Lys Pro Thr Leu Ser 
                405                 410                 415     
Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn Gly Asp Pro Val Lys 
            420                 425                 430         
Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser Pro Gly Ser Pro Arg 
        435                 440                 445             
His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys Ile Asp Leu Leu Ile 
    450                 455                 460                 
Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu Val His Leu Val Ala 
465                 470                 475                 480 
Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn Asn Ser Asn Lys Lys 
                485                 490                 495     
Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser Gly Gln Ala Asp Met 
            500                 505                 510         
Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg Ala Gln Tyr Ile Glu 
        515                 520                 525             
Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr Ile Leu Val Lys Lys 
    530                 535                 540                 
Gly Thr Arg Ile Thr Gly Ile Asn Asp Pro Arg Leu Arg Asn Pro Ser 
545                 550                 555                 560 
Asp Lys Phe Ile Tyr Ala Thr Val Lys Gln Ser Ser Val Asp Ile Tyr 
                565                 570                 575     
Phe Arg Arg Gln Val Glu Leu Ser Thr Met Tyr Arg His Met Glu Lys 
            580                 585                 590         
His Asn Tyr Glu Ser Ala Ala Glu Ala Ile Gln Ala Val Arg Asp Asn 
        595                 600                 605             
Lys Leu His Ala Phe Ile Trp Asp Ser Ala Val Leu Glu Phe Glu Ala 
    610                 615                 620                 
Ser Gln Lys Cys Asp Leu Val Thr Thr Gly Glu Leu Phe Phe Arg Ser 
625                 630                 635                 640 
Gly Phe Gly Ile Gly Met Arg Lys Asp Ser Pro Trp Lys Gln Asn Val 
                645                 650                 655     
Ser Leu Ser Ile Leu Lys Ser His Glu Asn Gly Phe Met Glu Asp Leu 
            660                 665                 670         
Asp Lys Thr Trp Val Arg Tyr Gln Glu Cys Asp Ser Gly Ser Ser Thr 
        675                 680                 685             
Met Val Arg Ser Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly 
    690                 695                 700                 
Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
705                 710                 715                 720 
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
                725                 730                 735     
Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val 
            740                 745                 750         
Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile 
        755                 760                 765             
Arg Val Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly 
    770                 775                 780                 
Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile 
785                 790                 795                 800 
Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val 
                805                 810                 815     
Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser 
            820                 825                 830         
Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu 
        835                 840                 845             
Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala 
    850                 855                 860                 
Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
865                 870                 875                 880 
Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met 
                885                 890                 895     
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser 
            900                 905                 910         
Pro Gly Lys 
        915 

<210> 7
<211> 394
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN1

<400> 7
Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      
Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          
Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              
Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  
Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  
Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      
Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         
Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             
Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 
Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 
Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     
Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu 
            180                 185                 190         
Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu 
        195                 200                 205             
Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser 
    210                 215                 220                 
Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met 
225                 230                 235                 240 
Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly 
                245                 250                 255     
Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile 
            260                 265                 270         
Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val 
        275                 280                 285             
Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro 
    290                 295                 300                 
Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu 
305                 310                 315                 320 
Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly 
                325                 330                 335     
Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser 
            340                 345                 350         
Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn 
        355                 360                 365             
Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly 
    370                 375                 380                 
Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met 
385                 390                 

<210> 8
<211> 150
<212> PRT
<213> Homo sapiens


<220> 
<223> Ligand-binding domain of GluN1 S1

<400> 8
Ser Thr Arg Leu Lys Ile Val Thr Ile His Gln Glu Pro Phe Val Tyr 
1               5                   10                  15      
Val Lys Pro Thr Leu Ser Asp Gly Thr Cys Lys Glu Glu Phe Thr Val 
            20                  25                  30          
Asn Gly Asp Pro Val Lys Lys Val Ile Cys Thr Gly Pro Asn Asp Thr 
        35                  40                  45              
Ser Pro Gly Ser Pro Arg His Thr Val Pro Gln Cys Cys Tyr Gly Phe 
    50                  55                  60                  
Cys Ile Asp Leu Leu Ile Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr 
65                  70                  75                  80  
Glu Val His Leu Val Ala Asp Gly Lys Phe Gly Thr Gln Glu Arg Val 
                85                  90                  95      
Asn Asn Ser Asn Lys Lys Glu Trp Asn Gly Met Met Gly Glu Leu Leu 
            100                 105                 110         
Ser Gly Gln Ala Asp Met Ile Val Ala Pro Leu Thr Ile Asn Asn Glu 
        115                 120                 125             
Arg Ala Gln Tyr Ile Glu Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu 
    130                 135                 140                 
Thr Ile Leu Val Lys Lys 
145                 150 

<210> 9

<400> 9

000

<210> 10
<211> 138
<212> PRT
<213> Homo sapiens


<220> 
<223> Ligand-binding domain of GluN1 S2

<400> 10
Arg Ile Thr Gly Ile Asn Asp Pro Arg Leu Arg Asn Pro Ser Asp Lys 
1               5                   10                  15      
Phe Ile Tyr Ala Thr Val Lys Gln Ser Ser Val Asp Ile Tyr Phe Arg 
            20                  25                  30          
Arg Gln Val Glu Leu Ser Thr Met Tyr Arg His Met Glu Lys His Asn 
        35                  40                  45              
Tyr Glu Ser Ala Ala Glu Ala Ile Gln Ala Val Arg Asp Asn Lys Leu 
    50                  55                  60                  
His Ala Phe Ile Trp Asp Ser Ala Val Leu Glu Phe Glu Ala Ser Gln 
65                  70                  75                  80  
Lys Cys Asp Leu Val Thr Thr Gly Glu Leu Phe Phe Arg Ser Gly Phe 
                85                  90                  95      
Gly Ile Gly Met Arg Lys Asp Ser Pro Trp Lys Gln Asn Val Ser Leu 
            100                 105                 110         
Ser Ile Leu Lys Ser His Glu Asn Gly Phe Met Glu Asp Leu Asp Lys 
        115                 120                 125             
Thr Trp Val Arg Tyr Gln Glu Cys Asp Ser 
    130                 135             

<210> 11
<211> 137
<212> PRT
<213> Homo sapiens


<220> 
<223> Ligand-binding domain of GluN1 S2 in NM_007327

<400> 11
Arg Ile Thr Gly Ile Asn Asp Pro Arg Leu Arg Asn Pro Ser Asp Lys 
1               5                   10                  15      
Phe Ile Tyr Ala Thr Val Lys Gln Ser Ser Val Asp Ile Tyr Phe Arg 
            20                  25                  30          
Arg Gln Val Glu Leu Ser Thr Met Tyr Arg His Met Glu Lys His Asn 
        35                  40                  45              
Tyr Glu Ser Ala Ala Glu Ala Ile Gln Ala Val Arg Asp Asn Lys Leu 
    50                  55                  60                  
His Ala Phe Ile Trp Asp Ser Ala Val Leu Glu Phe Glu Ala Ser Gln 
65                  70                  75                  80  
Lys Cys Asp Leu Val Thr Thr Gly Glu Leu Phe Phe Arg Ser Gly Phe 
                85                  90                  95      
Gly Ile Gly Met Arg Lys Asp Ser Pro Trp Lys Gln Asn Val Ser Leu 
            100                 105                 110         
Ser Ile Leu Lys Ser His Glu Asn Gly Phe Met Glu Asp Leu Asp Lys 
        115                 120                 125             
Thr Trp Val Arg Tyr Gln Glu Cys Asp 
    130                 135         

<210> 12
<211> 915
<212> PRT
<213> Artificial Sequence


<220> 
<223> protein seq of fusion protein #3 N2Becd-Fc

<400> 12
Met Lys Pro Arg Ala Glu Cys Cys Ser Pro Lys Phe Trp Leu Val Leu 
1               5                   10                  15      
Ala Val Leu Ala Val Ser Gly Ser Arg Ala Arg Ser Gln Lys Ser Pro 
            20                  25                  30          
Pro Ser Ile Gly Ile Ala Val Ile Leu Val Gly Thr Ser Asp Glu Val 
        35                  40                  45              
Ala Ile Lys Asp Ala His Glu Lys Asp Asp Phe His His Leu Ser Val 
    50                  55                  60                  
Val Pro Arg Val Glu Leu Val Ala Met Asn Glu Thr Asp Pro Lys Ser 
65                  70                  75                  80  
Ile Ile Thr Arg Ile Cys Asp Leu Met Ser Asp Arg Lys Ile Gln Gly 
                85                  90                  95      
Val Val Phe Ala Asp Asp Thr Asp Gln Glu Ala Ile Ala Gln Ile Leu 
            100                 105                 110         
Asp Phe Ile Ser Ala Gln Thr Leu Thr Pro Ile Leu Gly Ile His Gly 
        115                 120                 125             
Gly Ser Ser Met Ile Met Ala Asp Lys Asp Glu Ser Ser Met Phe Phe 
    130                 135                 140                 
Gln Phe Gly Pro Ser Ile Glu Gln Gln Ala Ser Val Met Leu Asn Ile 
145                 150                 155                 160 
Met Glu Glu Tyr Asp Trp Tyr Ile Phe Ser Ile Val Thr Thr Tyr Phe 
                165                 170                 175     
Pro Gly Tyr Gln Asp Phe Val Asn Lys Ile Arg Ser Thr Ile Glu Asn 
            180                 185                 190         
Ser Phe Val Gly Trp Glu Leu Glu Glu Val Leu Leu Leu Asp Met Ser 
        195                 200                 205             
Leu Asp Asp Gly Asp Ser Lys Ile Gln Asn Gln Leu Lys Lys Leu Gln 
    210                 215                 220                 
Ser Pro Ile Ile Leu Leu Tyr Cys Thr Lys Glu Glu Ala Thr Tyr Ile 
225                 230                 235                 240 
Phe Glu Val Ala Asn Ser Val Gly Leu Thr Gly Tyr Gly Tyr Thr Trp 
                245                 250                 255     
Ile Val Pro Ser Leu Val Ala Gly Asp Thr Asp Thr Val Pro Ala Glu 
            260                 265                 270         
Phe Pro Thr Gly Leu Ile Ser Val Ser Tyr Asp Glu Trp Asp Tyr Gly 
        275                 280                 285             
Leu Pro Ala Arg Val Arg Asp Gly Ile Ala Ile Ile Thr Thr Ala Ala 
    290                 295                 300                 
Ser Asp Met Leu Ser Glu His Ser Phe Ile Pro Glu Pro Lys Ser Ser 
305                 310                 315                 320 
Cys Tyr Asn Thr His Glu Lys Arg Ile Tyr Gln Ser Asn Met Leu Asn 
                325                 330                 335     
Arg Tyr Leu Ile Asn Val Thr Phe Glu Gly Arg Asn Leu Ser Phe Ser 
            340                 345                 350         
Glu Asp Gly Tyr Gln Met His Pro Lys Leu Val Ile Ile Leu Leu Asn 
        355                 360                 365             
Lys Glu Arg Lys Trp Glu Arg Val Gly Lys Trp Lys Asp Lys Ser Leu 
    370                 375                 380                 
Gln Met Lys Tyr Tyr Val Trp Pro Arg Met Cys Pro Glu Thr Glu Glu 
385                 390                 395                 400 
Gln Glu Asp Asp His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     
Val Ile Val Glu Ser Val Asp Pro Leu Ser Gly Thr Cys Met Arg Asn 
            420                 425                 430         
Thr Val Pro Cys Gln Lys Arg Ile Val Thr Glu Asn Lys Thr Asp Glu 
        435                 440                 445             
Glu Pro Gly Tyr Ile Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile 
    450                 455                 460                 
Leu Lys Lys Ile Ser Lys Ser Val Lys Phe Thr Tyr Asp Leu Tyr Leu 
465                 470                 475                 480 
Val Thr Asn Gly Lys His Gly Lys Lys Ile Asn Gly Thr Trp Asn Gly 
                485                 490                 495     
Met Ile Gly Glu Val Val Met Lys Arg Ala Tyr Met Ala Val Gly Ser 
            500                 505                 510         
Leu Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro 
        515                 520                 525             
Phe Ile Glu Thr Gly Ile Ser Val Met Val Ser Arg Gly Thr Gln Val 
    530                 535                 540                 
Ser Gly Leu Ser Asp Lys Lys Phe Gln Arg Pro Asn Asp Phe Ser Pro 
545                 550                 555                 560 
Pro Phe Arg Phe Gly Thr Val Pro Asn Gly Ser Thr Glu Arg Asn Ile 
                565                 570                 575     
Arg Asn Asn Tyr Ala Glu Met His Ala Tyr Met Gly Lys Phe Asn Gln 
            580                 585                 590         
Arg Gly Val Asp Asp Ala Leu Leu Ser Leu Lys Thr Gly Lys Leu Asp 
        595                 600                 605             
Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn Tyr Met Ala Gly Arg Asp 
    610                 615                 620                 
Glu Gly Cys Lys Leu Val Thr Ile Gly Ser Gly Lys Val Phe Ala Ser 
625                 630                 635                 640 
Thr Gly Tyr Gly Ile Ala Ile Gln Lys Asp Ser Gly Trp Lys Arg Gln 
                645                 650                 655     
Val Asp Leu Ala Ile Leu Gln Leu Phe Gly Asp Gly Glu Met Glu Glu 
            660                 665                 670         
Leu Glu Ala Leu Trp Leu Thr Gly Ile Cys His Asn Gly Ser Ser Thr 
        675                 680                 685             
Met Val Arg Ser Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly 
    690                 695                 700                 
Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
705                 710                 715                 720 
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
                725                 730                 735     
Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val 
            740                 745                 750         
Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile 
        755                 760                 765             
Arg Val Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly 
    770                 775                 780                 
Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile 
785                 790                 795                 800 
Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val 
                805                 810                 815     
Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser 
            820                 825                 830         
Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu 
        835                 840                 845             
Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala 
    850                 855                 860                 
Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
865                 870                 875                 880 
Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met 
                885                 890                 895     
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser 
            900                 905                 910         
Pro Gly Lys 
        915 

<210> 13
<211> 401
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN2B (including signal sequence)

<400> 13
Met Lys Pro Arg Ala Glu Cys Cys Ser Pro Lys Phe Trp Leu Val Leu 
1               5                   10                  15      
Ala Val Leu Ala Val Ser Gly Ser Arg Ala Arg Ser Gln Lys Ser Pro 
            20                  25                  30          
Pro Ser Ile Gly Ile Ala Val Ile Leu Val Gly Thr Ser Asp Glu Val 
        35                  40                  45              
Ala Ile Lys Asp Ala His Glu Lys Asp Asp Phe His His Leu Ser Val 
    50                  55                  60                  
Val Pro Arg Val Glu Leu Val Ala Met Asn Glu Thr Asp Pro Lys Ser 
65                  70                  75                  80  
Ile Ile Thr Arg Ile Cys Asp Leu Met Ser Asp Arg Lys Ile Gln Gly 
                85                  90                  95      
Val Val Phe Ala Asp Asp Thr Asp Gln Glu Ala Ile Ala Gln Ile Leu 
            100                 105                 110         
Asp Phe Ile Ser Ala Gln Thr Leu Thr Pro Ile Leu Gly Ile His Gly 
        115                 120                 125             
Gly Ser Ser Met Ile Met Ala Asp Lys Asp Glu Ser Ser Met Phe Phe 
    130                 135                 140                 
Gln Phe Gly Pro Ser Ile Glu Gln Gln Ala Ser Val Met Leu Asn Ile 
145                 150                 155                 160 
Met Glu Glu Tyr Asp Trp Tyr Ile Phe Ser Ile Val Thr Thr Tyr Phe 
                165                 170                 175     
Pro Gly Tyr Gln Asp Phe Val Asn Lys Ile Arg Ser Thr Ile Glu Asn 
            180                 185                 190         
Ser Phe Val Gly Trp Glu Leu Glu Glu Val Leu Leu Leu Asp Met Ser 
        195                 200                 205             
Leu Asp Asp Gly Asp Ser Lys Ile Gln Asn Gln Leu Lys Lys Leu Gln 
    210                 215                 220                 
Ser Pro Ile Ile Leu Leu Tyr Cys Thr Lys Glu Glu Ala Thr Tyr Ile 
225                 230                 235                 240 
Phe Glu Val Ala Asn Ser Val Gly Leu Thr Gly Tyr Gly Tyr Thr Trp 
                245                 250                 255     
Ile Val Pro Ser Leu Val Ala Gly Asp Thr Asp Thr Val Pro Ala Glu 
            260                 265                 270         
Phe Pro Thr Gly Leu Ile Ser Val Ser Tyr Asp Glu Trp Asp Tyr Gly 
        275                 280                 285             
Leu Pro Ala Arg Val Arg Asp Gly Ile Ala Ile Ile Thr Thr Ala Ala 
    290                 295                 300                 
Ser Asp Met Leu Ser Glu His Ser Phe Ile Pro Glu Pro Lys Ser Ser 
305                 310                 315                 320 
Cys Tyr Asn Thr His Glu Lys Arg Ile Tyr Gln Ser Asn Met Leu Asn 
                325                 330                 335     
Arg Tyr Leu Ile Asn Val Thr Phe Glu Gly Arg Asn Leu Ser Phe Ser 
            340                 345                 350         
Glu Asp Gly Tyr Gln Met His Pro Lys Leu Val Ile Ile Leu Leu Asn 
        355                 360                 365             
Lys Glu Arg Lys Trp Glu Arg Val Gly Lys Trp Lys Asp Lys Ser Leu 
    370                 375                 380                 
Gln Met Lys Tyr Tyr Val Trp Pro Arg Met Cys Pro Glu Thr Glu Glu 
385                 390                 395                 400 
Gln 
    

<210> 14
<211> 139
<212> PRT
<213> Homo sapiens


<220> 
<223> Ligand-binding domain of GluN2B S1

<400> 14
Glu Asp Asp His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe Val 
1               5                   10                  15      
Ile Val Glu Ser Val Asp Pro Leu Ser Gly Thr Cys Met Arg Asn Thr 
            20                  25                  30          
Val Pro Cys Gln Lys Arg Ile Val Thr Glu Asn Lys Thr Asp Glu Glu 
        35                  40                  45              
Pro Gly Tyr Ile Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu 
    50                  55                  60                  
Lys Lys Ile Ser Lys Ser Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val 
65                  70                  75                  80  
Thr Asn Gly Lys His Gly Lys Lys Ile Asn Gly Thr Trp Asn Gly Met 
                85                  90                  95      
Ile Gly Glu Val Val Met Lys Arg Ala Tyr Met Ala Val Gly Ser Leu 
            100                 105                 110         
Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe 
        115                 120                 125             
Ile Glu Thr Gly Ile Ser Val Met Val Ser Arg 
    130                 135                 

<210> 15
<211> 142
<212> PRT
<213> Homo sapiens


<220> 
<223> Ligand-binding domain of GluN2B S2

<400> 15
Gln Val Ser Gly Leu Ser Asp Lys Lys Phe Gln Arg Pro Asn Asp Phe 
1               5                   10                  15      
Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly Ser Thr Glu Arg 
            20                  25                  30          
Asn Ile Arg Asn Asn Tyr Ala Glu Met His Ala Tyr Met Gly Lys Phe 
        35                  40                  45              
Asn Gln Arg Gly Val Asp Asp Ala Leu Leu Ser Leu Lys Thr Gly Lys 
    50                  55                  60                  
Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn Tyr Met Ala Gly 
65                  70                  75                  80  
Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser Gly Lys Val Phe 
                85                  90                  95      
Ala Ser Thr Gly Tyr Gly Ile Ala Ile Gln Lys Asp Ser Gly Trp Lys 
            100                 105                 110         
Arg Gln Val Asp Leu Ala Ile Leu Gln Leu Phe Gly Asp Gly Glu Met 
        115                 120                 125             
Glu Glu Leu Glu Ala Leu Trp Leu Thr Gly Ile Cys His Asn 
    130                 135                 140         

<210> 16
<211> 361
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN2B in NM_000834

<400> 16
Pro Ser Ile Gly Ile Ala Val Ile Leu Val Gly Thr Ser Asp Glu Val 
1               5                   10                  15      
Ala Ile Lys Asp Ala His Glu Lys Asp Asp Phe His His Leu Ser Val 
            20                  25                  30          
Val Pro Arg Val Glu Leu Val Ala Met Asn Glu Thr Asp Pro Lys Ser 
        35                  40                  45              
Ile Ile Thr Arg Ile Cys Asp Leu Met Ser Asp Arg Lys Ile Gln Gly 
    50                  55                  60                  
Val Val Phe Ala Asp Asp Thr Asp Gln Glu Ala Ile Ala Gln Ile Leu 
65                  70                  75                  80  
Asp Phe Ile Ser Ala Gln Thr Leu Thr Pro Ile Leu Gly Ile His Gly 
                85                  90                  95      
Gly Ser Ser Met Ile Met Ala Asp Lys Asp Glu Ser Ser Met Phe Phe 
            100                 105                 110         
Gln Phe Gly Pro Ser Ile Glu Gln Gln Ala Ser Val Met Leu Asn Ile 
        115                 120                 125             
Met Glu Glu Tyr Asp Trp Tyr Ile Phe Ser Ile Val Thr Thr Tyr Phe 
    130                 135                 140                 
Pro Gly Tyr Gln Asp Phe Val Asn Lys Ile Arg Ser Thr Ile Glu Asn 
145                 150                 155                 160 
Ser Phe Val Gly Trp Glu Leu Glu Glu Val Leu Leu Leu Asp Met Ser 
                165                 170                 175     
Leu Asp Asp Gly Asp Ser Lys Ile Gln Asn Gln Leu Lys Lys Leu Gln 
            180                 185                 190         
Ser Pro Ile Ile Leu Leu Tyr Cys Thr Lys Glu Glu Ala Thr Tyr Ile 
        195                 200                 205             
Phe Glu Val Ala Asn Ser Val Gly Leu Thr Gly Tyr Gly Tyr Thr Trp 
    210                 215                 220                 
Ile Val Pro Ser Leu Val Ala Gly Asp Thr Asp Thr Val Pro Ala Glu 
225                 230                 235                 240 
Phe Pro Thr Gly Leu Ile Ser Val Ser Tyr Asp Glu Trp Asp Tyr Gly 
                245                 250                 255     
Leu Pro Ala Arg Val Arg Asp Gly Ile Ala Ile Ile Thr Thr Ala Ala 
            260                 265                 270         
Ser Asp Met Leu Ser Glu His Ser Phe Ile Pro Glu Pro Lys Ser Ser 
        275                 280                 285             
Cys Tyr Asn Thr His Glu Lys Arg Ile Tyr Gln Ser Asn Met Leu Asn 
    290                 295                 300                 
Arg Tyr Leu Ile Asn Val Thr Phe Glu Gly Arg Asn Leu Ser Phe Ser 
305                 310                 315                 320 
Glu Asp Gly Tyr Gln Met His Pro Lys Leu Val Ile Ile Leu Leu Asn 
                325                 330                 335     
Lys Glu Arg Lys Trp Glu Arg Val Gly Lys Trp Lys Asp Lys Ser Leu 
            340                 345                 350         
Gln Met Lys Tyr Tyr Val Trp Pro Arg 
        355                 360     

<210> 17
<211> 138
<212> PRT
<213> Homo sapiens


<220> 
<223> Ligand-binding domain of GluN2B S1 in NM_000834

<400> 17
Asp Asp His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe Val Ile 
1               5                   10                  15      
Val Glu Ser Val Asp Pro Leu Ser Gly Thr Cys Met Arg Asn Thr Val 
            20                  25                  30          
Pro Cys Gln Lys Arg Ile Val Thr Glu Asn Lys Thr Asp Glu Glu Pro 
        35                  40                  45              
Gly Tyr Ile Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu Lys 
    50                  55                  60                  
Lys Ile Ser Lys Ser Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val Thr 
65                  70                  75                  80  
Asn Gly Lys His Gly Lys Lys Ile Asn Gly Thr Trp Asn Gly Met Ile 
                85                  90                  95      
Gly Glu Val Val Met Lys Arg Ala Tyr Met Ala Val Gly Ser Leu Thr 
            100                 105                 110         
Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe Ile 
        115                 120                 125             
Glu Thr Gly Ile Ser Val Met Val Ser Arg 
    130                 135             

<210> 18
<211> 137
<212> PRT
<213> Homo sapiens


<220> 
<223> Ligand-binding domain of GluN2B S2 in NM_000834

<400> 18
Arg Ile Thr Gly Ile Asn Asp Pro Arg Leu Arg Asn Pro Ser Asp Lys 
1               5                   10                  15      
Phe Ile Tyr Ala Thr Val Lys Gln Ser Ser Val Asp Ile Tyr Phe Arg 
            20                  25                  30          
Arg Gln Val Glu Leu Ser Thr Met Tyr Arg His Met Glu Lys His Asn 
        35                  40                  45              
Tyr Glu Ser Ala Ala Glu Ala Ile Gln Ala Val Arg Asp Asn Lys Leu 
    50                  55                  60                  
His Ala Phe Ile Trp Asp Ser Ala Val Leu Glu Phe Glu Ala Ser Gln 
65                  70                  75                  80  
Lys Cys Asp Leu Val Thr Thr Gly Glu Leu Phe Phe Arg Ser Gly Phe 
                85                  90                  95      
Gly Ile Gly Met Arg Lys Asp Ser Pro Trp Lys Gln Asn Val Ser Leu 
            100                 105                 110         
Ser Ile Leu Lys Ser His Glu Asn Gly Phe Met Glu Asp Leu Asp Lys 
        115                 120                 125             
Thr Trp Val Arg Tyr Gln Glu Cys Asp 
    130                 135         

<210> 19
<211> 1594
<212> PRT
<213> Artificial Sequence


<220> 
<223> protein seq of fusion protein #4 N1ecd-N2Becd-Fc

<400> 19
Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      
Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          
Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              
Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  
Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  
Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      
Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         
Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             
Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 
Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 
Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     
Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu 
            180                 185                 190         
Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu 
        195                 200                 205             
Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser 
    210                 215                 220                 
Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met 
225                 230                 235                 240 
Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly 
                245                 250                 255     
Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile 
            260                 265                 270         
Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val 
        275                 280                 285             
Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro 
    290                 295                 300                 
Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu 
305                 310                 315                 320 
Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly 
                325                 330                 335     
Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser 
            340                 345                 350         
Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn 
        355                 360                 365             
Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly 
    370                 375                 380                 
Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile 
385                 390                 395                 400 
Val Thr Ile His Gln Glu Pro Phe Val Tyr Val Lys Pro Thr Leu Ser 
                405                 410                 415     
Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn Gly Asp Pro Val Lys 
            420                 425                 430         
Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser Pro Gly Ser Pro Arg 
        435                 440                 445             
His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys Ile Asp Leu Leu Ile 
    450                 455                 460                 
Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu Val His Leu Val Ala 
465                 470                 475                 480 
Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn Asn Ser Asn Lys Lys 
                485                 490                 495     
Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser Gly Gln Ala Asp Met 
            500                 505                 510         
Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg Ala Gln Tyr Ile Glu 
        515                 520                 525             
Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr Ile Leu Val Lys Lys 
    530                 535                 540                 
Gly Thr Arg Ile Thr Gly Ile Asn Asp Pro Arg Leu Arg Asn Pro Ser 
545                 550                 555                 560 
Asp Lys Phe Ile Tyr Ala Thr Val Lys Gln Ser Ser Val Asp Ile Tyr 
                565                 570                 575     
Phe Arg Arg Gln Val Glu Leu Ser Thr Met Tyr Arg His Met Glu Lys 
            580                 585                 590         
His Asn Tyr Glu Ser Ala Ala Glu Ala Ile Gln Ala Val Arg Asp Asn 
        595                 600                 605             
Lys Leu His Ala Phe Ile Trp Asp Ser Ala Val Leu Glu Phe Glu Ala 
    610                 615                 620                 
Ser Gln Lys Cys Asp Leu Val Thr Thr Gly Glu Leu Phe Phe Arg Ser 
625                 630                 635                 640 
Gly Phe Gly Ile Gly Met Arg Lys Asp Ser Pro Trp Lys Gln Asn Val 
                645                 650                 655     
Ser Leu Ser Ile Leu Lys Ser His Glu Asn Gly Phe Met Glu Asp Leu 
            660                 665                 670         
Asp Lys Thr Trp Val Arg Tyr Gln Glu Cys Asp Ser Gly Ser Thr Gly 
        675                 680                 685             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ala 
    690                 695                 700                 
Ala Ser Arg Gln Lys Ser Pro Pro Ser Ile Gly Ile Ala Val Ile Leu 
705                 710                 715                 720 
Val Gly Thr Ser Asp Glu Val Ala Ile Lys Asp Ala His Glu Lys Asp 
                725                 730                 735     
Asp Phe His His Leu Ser Val Val Pro Arg Val Glu Leu Val Ala Met 
            740                 745                 750         
Asn Glu Thr Asp Pro Lys Ser Ile Ile Thr Arg Ile Cys Asp Leu Met 
        755                 760                 765             
Ser Asp Arg Lys Ile Gln Gly Val Val Phe Ala Asp Asp Thr Asp Gln 
    770                 775                 780                 
Glu Ala Ile Ala Gln Ile Leu Asp Phe Ile Ser Ala Gln Thr Leu Thr 
785                 790                 795                 800 
Pro Ile Leu Gly Ile His Gly Gly Ser Ser Met Ile Met Ala Asp Lys 
                805                 810                 815     
Asp Glu Ser Ser Met Phe Phe Gln Phe Gly Pro Ser Ile Glu Gln Gln 
            820                 825                 830         
Ala Ser Val Met Leu Asn Ile Met Glu Glu Tyr Asp Trp Tyr Ile Phe 
        835                 840                 845             
Ser Ile Val Thr Thr Tyr Phe Pro Gly Tyr Gln Asp Phe Val Asn Lys 
    850                 855                 860                 
Ile Arg Ser Thr Ile Glu Asn Ser Phe Val Gly Trp Glu Leu Glu Glu 
865                 870                 875                 880 
Val Leu Leu Leu Asp Met Ser Leu Asp Asp Gly Asp Ser Lys Ile Gln 
                885                 890                 895     
Asn Gln Leu Lys Lys Leu Gln Ser Pro Ile Ile Leu Leu Tyr Cys Thr 
            900                 905                 910         
Lys Glu Glu Ala Thr Tyr Ile Phe Glu Val Ala Asn Ser Val Gly Leu 
        915                 920                 925             
Thr Gly Tyr Gly Tyr Thr Trp Ile Val Pro Ser Leu Val Ala Gly Asp 
    930                 935                 940                 
Thr Asp Thr Val Pro Ala Glu Phe Pro Thr Gly Leu Ile Ser Val Ser 
945                 950                 955                 960 
Tyr Asp Glu Trp Asp Tyr Gly Leu Pro Ala Arg Val Arg Asp Gly Ile 
                965                 970                 975     
Ala Ile Ile Thr Thr Ala Ala Ser Asp Met Leu Ser Glu His Ser Phe 
            980                 985                 990         
Ile Pro Glu Pro Lys Ser Ser Cys Tyr Asn Thr His Glu Lys Arg Ile 
        995                 1000                1005            
Tyr Gln Ser Asn Met Leu Asn Arg Tyr Leu Ile Asn Val Thr Phe Glu 
    1010                1015                1020                
Gly Arg Asn Leu Ser Phe Ser Glu Asp Gly Tyr Gln Met His Pro Lys 
1025                1030                1035                1040
Leu Val Ile Ile Leu Leu Asn Lys Glu Arg Lys Trp Glu Arg Val Gly 
                1045                1050                1055    
Lys Trp Lys Asp Lys Ser Leu Gln Met Lys Tyr Tyr Val Trp Pro Arg 
            1060                1065                1070        
Met Cys Pro Glu Thr Glu Glu Gln Glu Asp Asp His Leu Ser Ile Val 
        1075                1080                1085            
Thr Leu Glu Glu Ala Pro Phe Val Ile Val Glu Ser Val Asp Pro Leu 
    1090                1095                1100                
Ser Gly Thr Cys Met Arg Asn Thr Val Pro Cys Gln Lys Arg Ile Val 
1105                1110                1115                1120
Thr Glu Asn Lys Thr Asp Glu Glu Pro Gly Tyr Ile Lys Lys Cys Cys 
                1125                1130                1135    
Lys Gly Phe Cys Ile Asp Ile Leu Lys Lys Ile Ser Lys Ser Val Lys 
            1140                1145                1150        
Phe Thr Tyr Asp Leu Tyr Leu Val Thr Asn Gly Lys His Gly Lys Lys 
        1155                1160                1165            
Ile Asn Gly Thr Trp Asn Gly Met Ile Gly Glu Val Val Met Lys Arg 
    1170                1175                1180                
Ala Tyr Met Ala Val Gly Ser Leu Thr Ile Asn Glu Glu Arg Ser Glu 
1185                1190                1195                1200
Val Val Asp Phe Ser Val Pro Phe Ile Glu Thr Gly Ile Ser Val Met 
                1205                1210                1215    
Val Ser Arg Gly Thr Gln Val Ser Gly Leu Ser Asp Lys Lys Phe Gln 
            1220                1225                1230        
Arg Pro Asn Asp Phe Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn 
        1235                1240                1245            
Gly Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Ala Glu Met His Ala 
    1250                1255                1260                
Tyr Met Gly Lys Phe Asn Gln Arg Gly Val Asp Asp Ala Leu Leu Ser 
1265                1270                1275                1280
Leu Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu 
                1285                1290                1295    
Asn Tyr Met Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly 
            1300                1305                1310        
Ser Gly Lys Val Phe Ala Ser Thr Gly Tyr Gly Ile Ala Ile Gln Lys 
        1315                1320                1325            
Asp Ser Gly Trp Lys Arg Gln Val Asp Leu Ala Ile Leu Gln Leu Phe 
    1330                1335                1340                
Gly Asp Gly Glu Met Glu Glu Leu Glu Ala Leu Trp Leu Thr Gly Ile 
1345                1350                1355                1360
Cys His Asn Gly Ser Ser Thr Met Val Arg Ser Ser Lys Pro Thr Cys 
                1365                1370                1375    
Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
            1380                1385                1390        
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        1395                1400                1405            
Val Val Val Asp Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr Trp 
    1410                1415                1420                
Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg Glu 
1425                1430                1435                1440
Gln Gln Phe Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Ala 
                1445                1450                1455    
His Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His Asn 
            1460                1465                1470        
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly 
        1475                1480                1485            
Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu Glu 
    1490                1495                1500                
Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr 
1505                1510                1515                1520
Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp 
                1525                1530                1535    
Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe 
            1540                1545                1550        
Leu Tyr Ser Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly Asp 
        1555                1560                1565            
Val Phe Thr Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    1570                1575                1580                
Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys 
1585                1590                

<210> 20
<211> 23
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker between a GluN1-domain and GluN2B-domain in a fusion
      protein of NMDAR construct of the invention

<400> 20
Gly Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      
Gly Ser Gly Ala Ala Ser Arg 
            20              

<210> 21
<211> 373
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN2B

<400> 21
Gln Lys Ser Pro Pro Ser Ile Gly Ile Ala Val Ile Leu Val Gly Thr 
1               5                   10                  15      
Ser Asp Glu Val Ala Ile Lys Asp Ala His Glu Lys Asp Asp Phe His 
            20                  25                  30          
His Leu Ser Val Val Pro Arg Val Glu Leu Val Ala Met Asn Glu Thr 
        35                  40                  45              
Asp Pro Lys Ser Ile Ile Thr Arg Ile Cys Asp Leu Met Ser Asp Arg 
    50                  55                  60                  
Lys Ile Gln Gly Val Val Phe Ala Asp Asp Thr Asp Gln Glu Ala Ile 
65                  70                  75                  80  
Ala Gln Ile Leu Asp Phe Ile Ser Ala Gln Thr Leu Thr Pro Ile Leu 
                85                  90                  95      
Gly Ile His Gly Gly Ser Ser Met Ile Met Ala Asp Lys Asp Glu Ser 
            100                 105                 110         
Ser Met Phe Phe Gln Phe Gly Pro Ser Ile Glu Gln Gln Ala Ser Val 
        115                 120                 125             
Met Leu Asn Ile Met Glu Glu Tyr Asp Trp Tyr Ile Phe Ser Ile Val 
    130                 135                 140                 
Thr Thr Tyr Phe Pro Gly Tyr Gln Asp Phe Val Asn Lys Ile Arg Ser 
145                 150                 155                 160 
Thr Ile Glu Asn Ser Phe Val Gly Trp Glu Leu Glu Glu Val Leu Leu 
                165                 170                 175     
Leu Asp Met Ser Leu Asp Asp Gly Asp Ser Lys Ile Gln Asn Gln Leu 
            180                 185                 190         
Lys Lys Leu Gln Ser Pro Ile Ile Leu Leu Tyr Cys Thr Lys Glu Glu 
        195                 200                 205             
Ala Thr Tyr Ile Phe Glu Val Ala Asn Ser Val Gly Leu Thr Gly Tyr 
    210                 215                 220                 
Gly Tyr Thr Trp Ile Val Pro Ser Leu Val Ala Gly Asp Thr Asp Thr 
225                 230                 235                 240 
Val Pro Ala Glu Phe Pro Thr Gly Leu Ile Ser Val Ser Tyr Asp Glu 
                245                 250                 255     
Trp Asp Tyr Gly Leu Pro Ala Arg Val Arg Asp Gly Ile Ala Ile Ile 
            260                 265                 270         
Thr Thr Ala Ala Ser Asp Met Leu Ser Glu His Ser Phe Ile Pro Glu 
        275                 280                 285             
Pro Lys Ser Ser Cys Tyr Asn Thr His Glu Lys Arg Ile Tyr Gln Ser 
    290                 295                 300                 
Asn Met Leu Asn Arg Tyr Leu Ile Asn Val Thr Phe Glu Gly Arg Asn 
305                 310                 315                 320 
Leu Ser Phe Ser Glu Asp Gly Tyr Gln Met His Pro Lys Leu Val Ile 
                325                 330                 335     
Ile Leu Leu Asn Lys Glu Arg Lys Trp Glu Arg Val Gly Lys Trp Lys 
            340                 345                 350         
Asp Lys Ser Leu Gln Met Lys Tyr Tyr Val Trp Pro Arg Met Cys Pro 
        355                 360                 365             
Glu Thr Glu Glu Gln 
    370             

<210> 22
<211> 639
<212> PRT
<213> Artificial Sequence


<220> 
<223> protein seq of fusion protein #5 N2A-ATD-Fc

<400> 22
Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu 
1               5                   10                  15      
Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro 
            20                  25                  30          
Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu 
        35                  40                  45              
Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro 
    50                  55                  60                  
Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys 
65                  70                  75                  80  
Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His 
                85                  90                  95      
Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met 
            100                 105                 110         
Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His 
        115                 120                 125             
Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe 
    130                 135                 140                 
Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys 
145                 150                 155                 160 
Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile 
                165                 170                 175     
Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp 
            180                 185                 190         
Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr 
        195                 200                 205             
Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser 
    210                 215                 220                 
Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu 
225                 230                 235                 240 
Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile 
                245                 250                 255     
Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe 
            260                 265                 270         
Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu 
        275                 280                 285             
Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser 
    290                 295                 300                 
Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys 
305                 310                 315                 320 
Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro 
                325                 330                 335     
Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu 
            340                 345                 350         
Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys 
        355                 360                 365             
Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser 
    370                 375                 380                 
Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu 
385                 390                 395                 400 
Pro Asp Asp Asn His Leu Ser Ile Gly Ser Ser Thr Met Val Arg Ser 
                405                 410                 415     
Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val 
            420                 425                 430         
Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        435                 440                 445             
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Asp Asp Pro Glu 
    450                 455                 460                 
Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg 
465                 470                 475                 480 
Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg Val Val Ser 
                485                 490                 495     
Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys 
            500                 505                 510         
Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        515                 520                 525             
Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly 
    530                 535                 540                 
Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met 
545                 550                 555                 560 
Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn 
                565                 570                 575     
Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser 
            580                 585                 590         
Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Pro Thr Ser Glu 
        595                 600                 605             
Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met His Glu Ala Leu 
    610                 615                 620                 
His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys 
625                 630                 635                 

<210> 23
<211> 408
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN2A (including signal sequence)

<400> 23
Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu 
1               5                   10                  15      
Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro 
            20                  25                  30          
Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu 
        35                  40                  45              
Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro 
    50                  55                  60                  
Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys 
65                  70                  75                  80  
Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His 
                85                  90                  95      
Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met 
            100                 105                 110         
Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His 
        115                 120                 125             
Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe 
    130                 135                 140                 
Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys 
145                 150                 155                 160 
Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile 
                165                 170                 175     
Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp 
            180                 185                 190         
Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr 
        195                 200                 205             
Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser 
    210                 215                 220                 
Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu 
225                 230                 235                 240 
Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile 
                245                 250                 255     
Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe 
            260                 265                 270         
Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu 
        275                 280                 285             
Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser 
    290                 295                 300                 
Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys 
305                 310                 315                 320 
Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro 
                325                 330                 335     
Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu 
            340                 345                 350         
Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys 
        355                 360                 365             
Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser 
    370                 375                 380                 
Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu 
385                 390                 395                 400 
Pro Asp Asp Asn His Leu Ser Ile 
                405             

<210> 24
<211> 361
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN2A in NM_001134407

<400> 24
Pro Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr 
1               5                   10                  15      
Glu Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu 
            20                  25                  30          
Pro Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro 
        35                  40                  45              
Lys Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile 
    50                  55                  60                  
His Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln 
65                  70                  75                  80  
Met Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile 
                85                  90                  95      
His Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr 
            100                 105                 110         
Phe Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu 
        115                 120                 125             
Lys Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr 
    130                 135                 140                 
Ile Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val 
145                 150                 155                 160 
Asp Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp 
                165                 170                 175     
Thr Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His 
            180                 185                 190         
Ser Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile 
        195                 200                 205             
Leu Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp 
    210                 215                 220                 
Ile Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu 
225                 230                 235                 240 
Phe Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser 
                245                 250                 255     
Leu Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala 
            260                 265                 270         
Ser Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser 
        275                 280                 285             
Cys Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His 
    290                 295                 300                 
Pro Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr 
305                 310                 315                 320 
Glu Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn 
                325                 330                 335     
Lys Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu 
            340                 345                 350         
Ser Leu Arg His Ala Val Trp Pro Arg 
        355                 360     

<210> 25
<211> 639
<212> PRT
<213> Artificial Sequence


<220> 
<223> protein seq of fusion protein #6 N2B-ATD-Fc

<400> 25
Met Lys Pro Arg Ala Glu Cys Cys Ser Pro Lys Phe Trp Leu Val Leu 
1               5                   10                  15      
Ala Val Leu Ala Val Ser Gly Ser Arg Ala Arg Ser Gln Lys Ser Pro 
            20                  25                  30          
Pro Ser Ile Gly Ile Ala Val Ile Leu Val Gly Thr Ser Asp Glu Val 
        35                  40                  45              
Ala Ile Lys Asp Ala His Glu Lys Asp Asp Phe His His Leu Ser Val 
    50                  55                  60                  
Val Pro Arg Val Glu Leu Val Ala Met Asn Glu Thr Asp Pro Lys Ser 
65                  70                  75                  80  
Ile Ile Thr Arg Ile Cys Asp Leu Met Ser Asp Arg Lys Ile Gln Gly 
                85                  90                  95      
Val Val Phe Ala Asp Asp Thr Asp Gln Glu Ala Ile Ala Gln Ile Leu 
            100                 105                 110         
Asp Phe Ile Ser Ala Gln Thr Leu Thr Pro Ile Leu Gly Ile His Gly 
        115                 120                 125             
Gly Ser Ser Met Ile Met Ala Asp Lys Asp Glu Ser Ser Met Phe Phe 
    130                 135                 140                 
Gln Phe Gly Pro Ser Ile Glu Gln Gln Ala Ser Val Met Leu Asn Ile 
145                 150                 155                 160 
Met Glu Glu Tyr Asp Trp Tyr Ile Phe Ser Ile Val Thr Thr Tyr Phe 
                165                 170                 175     
Pro Gly Tyr Gln Asp Phe Val Asn Lys Ile Arg Ser Thr Ile Glu Asn 
            180                 185                 190         
Ser Phe Val Gly Trp Glu Leu Glu Glu Val Leu Leu Leu Asp Met Ser 
        195                 200                 205             
Leu Asp Asp Gly Asp Ser Lys Ile Gln Asn Gln Leu Lys Lys Leu Gln 
    210                 215                 220                 
Ser Pro Ile Ile Leu Leu Tyr Cys Thr Lys Glu Glu Ala Thr Tyr Ile 
225                 230                 235                 240 
Phe Glu Val Ala Asn Ser Val Gly Leu Thr Gly Tyr Gly Tyr Thr Trp 
                245                 250                 255     
Ile Val Pro Ser Leu Val Ala Gly Asp Thr Asp Thr Val Pro Ala Glu 
            260                 265                 270         
Phe Pro Thr Gly Leu Ile Ser Val Ser Tyr Asp Glu Trp Asp Tyr Gly 
        275                 280                 285             
Leu Pro Ala Arg Val Arg Asp Gly Ile Ala Ile Ile Thr Thr Ala Ala 
    290                 295                 300                 
Ser Asp Met Leu Ser Glu His Ser Phe Ile Pro Glu Pro Lys Ser Ser 
305                 310                 315                 320 
Cys Tyr Asn Thr His Glu Lys Arg Ile Tyr Gln Ser Asn Met Leu Asn 
                325                 330                 335     
Arg Tyr Leu Ile Asn Val Thr Phe Glu Gly Arg Asn Leu Ser Phe Ser 
            340                 345                 350         
Glu Asp Gly Tyr Gln Met His Pro Lys Leu Val Ile Ile Leu Leu Asn 
        355                 360                 365             
Lys Glu Arg Lys Trp Glu Arg Val Gly Lys Trp Lys Asp Lys Ser Leu 
    370                 375                 380                 
Gln Met Lys Tyr Tyr Val Trp Pro Arg Met Cys Pro Glu Thr Glu Glu 
385                 390                 395                 400 
Gln Glu Asp Asp His Leu Ser Ile Gly Ser Ser Thr Met Val Arg Ser 
                405                 410                 415     
Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val 
            420                 425                 430         
Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        435                 440                 445             
Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Asp Asp Pro Glu 
    450                 455                 460                 
Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg 
465                 470                 475                 480 
Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg Val Val Ser 
                485                 490                 495     
Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys 
            500                 505                 510         
Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        515                 520                 525             
Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly 
    530                 535                 540                 
Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met 
545                 550                 555                 560 
Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn 
                565                 570                 575     
Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser 
            580                 585                 590         
Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Pro Thr Ser Glu 
        595                 600                 605             
Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met His Glu Ala Leu 
    610                 615                 620                 
His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys 
625                 630                 635                 

<210> 26
<211> 408
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN2B (including signal sequence)

<400> 26
Met Lys Pro Arg Ala Glu Cys Cys Ser Pro Lys Phe Trp Leu Val Leu 
1               5                   10                  15      
Ala Val Leu Ala Val Ser Gly Ser Arg Ala Arg Ser Gln Lys Ser Pro 
            20                  25                  30          
Pro Ser Ile Gly Ile Ala Val Ile Leu Val Gly Thr Ser Asp Glu Val 
        35                  40                  45              
Ala Ile Lys Asp Ala His Glu Lys Asp Asp Phe His His Leu Ser Val 
    50                  55                  60                  
Val Pro Arg Val Glu Leu Val Ala Met Asn Glu Thr Asp Pro Lys Ser 
65                  70                  75                  80  
Ile Ile Thr Arg Ile Cys Asp Leu Met Ser Asp Arg Lys Ile Gln Gly 
                85                  90                  95      
Val Val Phe Ala Asp Asp Thr Asp Gln Glu Ala Ile Ala Gln Ile Leu 
            100                 105                 110         
Asp Phe Ile Ser Ala Gln Thr Leu Thr Pro Ile Leu Gly Ile His Gly 
        115                 120                 125             
Gly Ser Ser Met Ile Met Ala Asp Lys Asp Glu Ser Ser Met Phe Phe 
    130                 135                 140                 
Gln Phe Gly Pro Ser Ile Glu Gln Gln Ala Ser Val Met Leu Asn Ile 
145                 150                 155                 160 
Met Glu Glu Tyr Asp Trp Tyr Ile Phe Ser Ile Val Thr Thr Tyr Phe 
                165                 170                 175     
Pro Gly Tyr Gln Asp Phe Val Asn Lys Ile Arg Ser Thr Ile Glu Asn 
            180                 185                 190         
Ser Phe Val Gly Trp Glu Leu Glu Glu Val Leu Leu Leu Asp Met Ser 
        195                 200                 205             
Leu Asp Asp Gly Asp Ser Lys Ile Gln Asn Gln Leu Lys Lys Leu Gln 
    210                 215                 220                 
Ser Pro Ile Ile Leu Leu Tyr Cys Thr Lys Glu Glu Ala Thr Tyr Ile 
225                 230                 235                 240 
Phe Glu Val Ala Asn Ser Val Gly Leu Thr Gly Tyr Gly Tyr Thr Trp 
                245                 250                 255     
Ile Val Pro Ser Leu Val Ala Gly Asp Thr Asp Thr Val Pro Ala Glu 
            260                 265                 270         
Phe Pro Thr Gly Leu Ile Ser Val Ser Tyr Asp Glu Trp Asp Tyr Gly 
        275                 280                 285             
Leu Pro Ala Arg Val Arg Asp Gly Ile Ala Ile Ile Thr Thr Ala Ala 
    290                 295                 300                 
Ser Asp Met Leu Ser Glu His Ser Phe Ile Pro Glu Pro Lys Ser Ser 
305                 310                 315                 320 
Cys Tyr Asn Thr His Glu Lys Arg Ile Tyr Gln Ser Asn Met Leu Asn 
                325                 330                 335     
Arg Tyr Leu Ile Asn Val Thr Phe Glu Gly Arg Asn Leu Ser Phe Ser 
            340                 345                 350         
Glu Asp Gly Tyr Gln Met His Pro Lys Leu Val Ile Ile Leu Leu Asn 
        355                 360                 365             
Lys Glu Arg Lys Trp Glu Arg Val Gly Lys Trp Lys Asp Lys Ser Leu 
    370                 375                 380                 
Gln Met Lys Tyr Tyr Val Trp Pro Arg Met Cys Pro Glu Thr Glu Glu 
385                 390                 395                 400 
Gln Glu Asp Asp His Leu Ser Ile 
                405             

<210> 27
<211> 1035
<212> PRT
<213> Artificial Sequence


<220> 
<223> protein seq of fusion protein #7 N1-ATD-N2A-ATD-Fc

<400> 27
Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      
Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          
Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              
Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  
Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  
Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      
Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         
Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             
Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 
Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 
Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     
Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu 
            180                 185                 190         
Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu 
        195                 200                 205             
Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser 
    210                 215                 220                 
Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met 
225                 230                 235                 240 
Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly 
                245                 250                 255     
Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile 
            260                 265                 270         
Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val 
        275                 280                 285             
Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro 
    290                 295                 300                 
Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu 
305                 310                 315                 320 
Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly 
                325                 330                 335     
Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser 
            340                 345                 350         
Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn 
        355                 360                 365             
Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly 
    370                 375                 380                 
Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile 
385                 390                 395                 400 
Gly Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                405                 410                 415     
Gly Ser Gly Ala Ala Ser Arg Glu Lys Gly Pro Pro Ala Leu Asn Ile 
            420                 425                 430         
Ala Val Met Leu Gly His Ser His Asp Val Thr Glu Arg Glu Leu Arg 
        435                 440                 445             
Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro Leu Asp Val Asn 
    450                 455                 460                 
Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys Ser Leu Ile Thr 
465                 470                 475                 480 
His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His Gly Leu Val Phe 
                485                 490                 495     
Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met Leu Asp Phe Ile 
            500                 505                 510         
Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His Gly Gly Ala Ser 
        515                 520                 525             
Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe Phe Gln Phe Gly 
    530                 535                 540                 
Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys Ile Met Gln Asp 
545                 550                 555                 560 
Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile Phe Pro Gly Tyr 
                565                 570                 575     
Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp Asn Ser Phe Val 
            580                 585                 590         
Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr Ser Phe Glu Asp 
        595                 600                 605             
Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser Ser Val Ile Leu 
    610                 615                 620                 
Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu Ser Glu Ala Arg 
625                 630                 635                 640 
Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile Val Pro Ser Leu 
                645                 650                 655     
Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe Pro Ser Gly Leu 
            660                 665                 670         
Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu Glu Ala Arg Val 
        675                 680                 685             
Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser Ser Met Leu Glu 
    690                 695                 700                 
Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys Tyr Gly Gln Met 
705                 710                 715                 720 
Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro Phe Met Val Asn 
                725                 730                 735     
Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu Glu Gly Tyr Gln 
            740                 745                 750         
Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys Asp Arg Glu Trp 
        755                 760                 765             
Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser Leu Arg His Ala 
    770                 775                 780                 
Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu Pro Asp Asp Asn 
785                 790                 795                 800 
His Leu Ser Ile Gly Ser Ser Thr Met Val Arg Ser Ser Lys Pro Thr 
                805                 810                 815     
Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
            820                 825                 830         
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        835                 840                 845             
Cys Val Val Val Asp Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr 
    850                 855                 860                 
Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg 
865                 870                 875                 880 
Glu Gln Gln Phe Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile 
                885                 890                 895     
Ala His Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His 
            900                 905                 910         
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg 
        915                 920                 925             
Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu 
    930                 935                 940                 
Glu Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe 
945                 950                 955                 960 
Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu 
                965                 970                 975     
Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr 
            980                 985                 990         
Phe Leu Tyr Ser Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly 
        995                 1000                1005            
Asp Val Phe Thr Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    1010                1015                1020                
Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys 
1025                1030                1035

<210> 28
<211> 400
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN1 (including signal sequence)

<400> 28
Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      
Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          
Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              
Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  
Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  
Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      
Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         
Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             
Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 
Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 
Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     
Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu 
            180                 185                 190         
Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu 
        195                 200                 205             
Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser 
    210                 215                 220                 
Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met 
225                 230                 235                 240 
Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly 
                245                 250                 255     
Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile 
            260                 265                 270         
Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val 
        275                 280                 285             
Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro 
    290                 295                 300                 
Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu 
305                 310                 315                 320 
Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly 
                325                 330                 335     
Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser 
            340                 345                 350         
Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn 
        355                 360                 365             
Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly 
    370                 375                 380                 
Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile 
385                 390                 395                 400 



<210> 29
<211> 381
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN2A

<400> 29
Glu Lys Gly Pro Pro Ala Leu Asn Ile Ala Val Met Leu Gly His Ser 
1               5                   10                  15      
His Asp Val Thr Glu Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln 
            20                  25                  30          
Ala Ala Gly Leu Pro Leu Asp Val Asn Val Val Ala Leu Leu Met Asn 
        35                  40                  45              
Arg Thr Asp Pro Lys Ser Leu Ile Thr His Val Cys Asp Leu Met Ser 
    50                  55                  60                  
Gly Ala Arg Ile His Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu 
65                  70                  75                  80  
Ala Val Ala Gln Met Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro 
                85                  90                  95      
Ile Leu Gly Ile His Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp 
            100                 105                 110         
Pro Thr Ser Thr Phe Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala 
        115                 120                 125             
Thr Val Met Leu Lys Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser 
    130                 135                 140                 
Leu Val Thr Thr Ile Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val 
145                 150                 155                 160 
Lys Thr Thr Val Asp Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val 
                165                 170                 175     
Ile Thr Leu Asp Thr Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu 
            180                 185                 190         
Lys Lys Ile His Ser Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu 
        195                 200                 205             
Ala Val Leu Ile Leu Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr 
    210                 215                 220                 
Asp Phe Phe Trp Ile Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu 
225                 230                 235                 240 
Ile Pro Lys Glu Phe Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp 
                245                 250                 255     
Trp Asp Tyr Ser Leu Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu 
            260                 265                 270         
Thr Thr Ala Ala Ser Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu 
        275                 280                 285             
Ala Lys Ala Ser Cys Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met 
    290                 295                 300                 
His Thr Leu His Pro Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp 
305                 310                 315                 320 
Leu Ser Phe Thr Glu Glu Gly Tyr Gln Val His Pro Arg Leu Val Val 
                325                 330                 335     
Ile Val Leu Asn Lys Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu 
            340                 345                 350         
Asn His Thr Leu Ser Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser 
        355                 360                 365             
Phe Ser Asp Cys Glu Pro Asp Asp Asn His Leu Ser Ile 
    370                 375                 380     

<210> 30
<211> 1034
<212> PRT
<213> Artificial Sequence


<220> 
<223> protein seq of fusion protein #8 N1-ATD-N2B-ATD-Fc

<400> 30
Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      
Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          
Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              
Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  
Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  
Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      
Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         
Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             
Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 
Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 
Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     
Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu 
            180                 185                 190         
Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu 
        195                 200                 205             
Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser 
    210                 215                 220                 
Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met 
225                 230                 235                 240 
Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly 
                245                 250                 255     
Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile 
            260                 265                 270         
Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val 
        275                 280                 285             
Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro 
    290                 295                 300                 
Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu 
305                 310                 315                 320 
Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly 
                325                 330                 335     
Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser 
            340                 345                 350         
Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn 
        355                 360                 365             
Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly 
    370                 375                 380                 
Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile 
385                 390                 395                 400 
Gly Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                405                 410                 415     
Gly Ser Gly Ala Ala Ser Arg Gln Lys Ser Pro Pro Ser Ile Gly Ile 
            420                 425                 430         
Ala Val Ile Leu Val Gly Thr Ser Asp Glu Val Ala Ile Lys Asp Ala 
        435                 440                 445             
His Glu Lys Asp Asp Phe His His Leu Ser Val Val Pro Arg Val Glu 
    450                 455                 460                 
Leu Val Ala Met Asn Glu Thr Asp Pro Lys Ser Ile Ile Thr Arg Ile 
465                 470                 475                 480 
Cys Asp Leu Met Ser Asp Arg Lys Ile Gln Gly Val Val Phe Ala Asp 
                485                 490                 495     
Asp Thr Asp Gln Glu Ala Ile Ala Gln Ile Leu Asp Phe Ile Ser Ala 
            500                 505                 510         
Gln Thr Leu Thr Pro Ile Leu Gly Ile His Gly Gly Ser Ser Met Ile 
        515                 520                 525             
Met Ala Asp Lys Asp Glu Ser Ser Met Phe Phe Gln Phe Gly Pro Ser 
    530                 535                 540                 
Ile Glu Gln Gln Ala Ser Val Met Leu Asn Ile Met Glu Glu Tyr Asp 
545                 550                 555                 560 
Trp Tyr Ile Phe Ser Ile Val Thr Thr Tyr Phe Pro Gly Tyr Gln Asp 
                565                 570                 575     
Phe Val Asn Lys Ile Arg Ser Thr Ile Glu Asn Ser Phe Val Gly Trp 
            580                 585                 590         
Glu Leu Glu Glu Val Leu Leu Leu Asp Met Ser Leu Asp Asp Gly Asp 
        595                 600                 605             
Ser Lys Ile Gln Asn Gln Leu Lys Lys Leu Gln Ser Pro Ile Ile Leu 
    610                 615                 620                 
Leu Tyr Cys Thr Lys Glu Glu Ala Thr Tyr Ile Phe Glu Val Ala Asn 
625                 630                 635                 640 
Ser Val Gly Leu Thr Gly Tyr Gly Tyr Thr Trp Ile Val Pro Ser Leu 
                645                 650                 655     
Val Ala Gly Asp Thr Asp Thr Val Pro Ala Glu Phe Pro Thr Gly Leu 
            660                 665                 670         
Ile Ser Val Ser Tyr Asp Glu Trp Asp Tyr Gly Leu Pro Ala Arg Val 
        675                 680                 685             
Arg Asp Gly Ile Ala Ile Ile Thr Thr Ala Ala Ser Asp Met Leu Ser 
    690                 695                 700                 
Glu His Ser Phe Ile Pro Glu Pro Lys Ser Ser Cys Tyr Asn Thr His 
705                 710                 715                 720 
Glu Lys Arg Ile Tyr Gln Ser Asn Met Leu Asn Arg Tyr Leu Ile Asn 
                725                 730                 735     
Val Thr Phe Glu Gly Arg Asn Leu Ser Phe Ser Glu Asp Gly Tyr Gln 
            740                 745                 750         
Met His Pro Lys Leu Val Ile Ile Leu Leu Asn Lys Glu Arg Lys Trp 
        755                 760                 765             
Glu Arg Val Gly Lys Trp Lys Asp Lys Ser Leu Gln Met Lys Tyr Tyr 
    770                 775                 780                 
Val Trp Pro Arg Met Cys Pro Glu Thr Glu Glu Gln Glu Asp Asp His 
785                 790                 795                 800 
Leu Ser Ile Gly Ser Ser Thr Met Val Arg Ser Ser Lys Pro Thr Cys 
                805                 810                 815     
Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
            820                 825                 830         
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        835                 840                 845             
Val Val Val Asp Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr Trp 
    850                 855                 860                 
Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg Glu 
865                 870                 875                 880 
Gln Gln Phe Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Ala 
                885                 890                 895     
His Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His Asn 
            900                 905                 910         
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly 
        915                 920                 925             
Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu Glu 
    930                 935                 940                 
Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr 
945                 950                 955                 960 
Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp 
                965                 970                 975     
Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe 
            980                 985                 990         
Leu Tyr Ser Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly Asp 
        995                 1000                1005            
Val Phe Thr Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    1010                1015                1020                
Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys 
1025                1030                

<210> 31
<211> 400
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN1 (including signal sequence)

<400> 31
Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      
Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          
Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              
Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  
Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  
Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      
Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         
Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             
Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 
Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 
Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     
Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu 
            180                 185                 190         
Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu 
        195                 200                 205             
Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser 
    210                 215                 220                 
Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met 
225                 230                 235                 240 
Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly 
                245                 250                 255     
Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile 
            260                 265                 270         
Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val 
        275                 280                 285             
Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro 
    290                 295                 300                 
Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu 
305                 310                 315                 320 
Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly 
                325                 330                 335     
Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser 
            340                 345                 350         
Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn 
        355                 360                 365             
Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly 
    370                 375                 380                 
Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile 
385                 390                 395                 400 



<210> 32
<211> 380
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN2B

<400> 32
Gln Lys Ser Pro Pro Ser Ile Gly Ile Ala Val Ile Leu Val Gly Thr 
1               5                   10                  15      
Ser Asp Glu Val Ala Ile Lys Asp Ala His Glu Lys Asp Asp Phe His 
            20                  25                  30          
His Leu Ser Val Val Pro Arg Val Glu Leu Val Ala Met Asn Glu Thr 
        35                  40                  45              
Asp Pro Lys Ser Ile Ile Thr Arg Ile Cys Asp Leu Met Ser Asp Arg 
    50                  55                  60                  
Lys Ile Gln Gly Val Val Phe Ala Asp Asp Thr Asp Gln Glu Ala Ile 
65                  70                  75                  80  
Ala Gln Ile Leu Asp Phe Ile Ser Ala Gln Thr Leu Thr Pro Ile Leu 
                85                  90                  95      
Gly Ile His Gly Gly Ser Ser Met Ile Met Ala Asp Lys Asp Glu Ser 
            100                 105                 110         
Ser Met Phe Phe Gln Phe Gly Pro Ser Ile Glu Gln Gln Ala Ser Val 
        115                 120                 125             
Met Leu Asn Ile Met Glu Glu Tyr Asp Trp Tyr Ile Phe Ser Ile Val 
    130                 135                 140                 
Thr Thr Tyr Phe Pro Gly Tyr Gln Asp Phe Val Asn Lys Ile Arg Ser 
145                 150                 155                 160 
Thr Ile Glu Asn Ser Phe Val Gly Trp Glu Leu Glu Glu Val Leu Leu 
                165                 170                 175     
Leu Asp Met Ser Leu Asp Asp Gly Asp Ser Lys Ile Gln Asn Gln Leu 
            180                 185                 190         
Lys Lys Leu Gln Ser Pro Ile Ile Leu Leu Tyr Cys Thr Lys Glu Glu 
        195                 200                 205             
Ala Thr Tyr Ile Phe Glu Val Ala Asn Ser Val Gly Leu Thr Gly Tyr 
    210                 215                 220                 
Gly Tyr Thr Trp Ile Val Pro Ser Leu Val Ala Gly Asp Thr Asp Thr 
225                 230                 235                 240 
Val Pro Ala Glu Phe Pro Thr Gly Leu Ile Ser Val Ser Tyr Asp Glu 
                245                 250                 255     
Trp Asp Tyr Gly Leu Pro Ala Arg Val Arg Asp Gly Ile Ala Ile Ile 
            260                 265                 270         
Thr Thr Ala Ala Ser Asp Met Leu Ser Glu His Ser Phe Ile Pro Glu 
        275                 280                 285             
Pro Lys Ser Ser Cys Tyr Asn Thr His Glu Lys Arg Ile Tyr Gln Ser 
    290                 295                 300                 
Asn Met Leu Asn Arg Tyr Leu Ile Asn Val Thr Phe Glu Gly Arg Asn 
305                 310                 315                 320 
Leu Ser Phe Ser Glu Asp Gly Tyr Gln Met His Pro Lys Leu Val Ile 
                325                 330                 335     
Ile Leu Leu Asn Lys Glu Arg Lys Trp Glu Arg Val Gly Lys Trp Lys 
            340                 345                 350         
Asp Lys Ser Leu Gln Met Lys Tyr Tyr Val Trp Pro Arg Met Cys Pro 
        355                 360                 365             
Glu Thr Glu Glu Gln Glu Asp Asp His Leu Ser Ile 
    370                 375                 380 

<210> 33
<211> 1233
<212> PRT
<213> Homo sapiens


<220> 
<223> Human GluN2C NM_000835

<400> 33
Met Gly Gly Ala Leu Gly Pro Ala Leu Leu Leu Thr Ser Leu Phe Gly 
1               5                   10                  15      
Ala Trp Ala Gly Leu Gly Pro Gly Gln Gly Glu Gln Gly Met Thr Val 
            20                  25                  30          
Ala Val Val Phe Ser Ser Ser Gly Pro Pro Gln Ala Gln Phe Arg Ala 
        35                  40                  45              
Arg Leu Thr Pro Gln Ser Phe Leu Asp Leu Pro Leu Glu Ile Gln Pro 
    50                  55                  60                  
Leu Thr Val Gly Val Asn Thr Thr Asn Pro Ser Ser Leu Leu Thr Gln 
65                  70                  75                  80  
Ile Cys Gly Leu Leu Gly Ala Ala His Val His Gly Ile Val Phe Glu 
                85                  90                  95      
Asp Asn Val Asp Thr Glu Ala Val Ala Gln Ile Leu Asp Phe Ile Ser 
            100                 105                 110         
Ser Gln Thr His Val Pro Ile Leu Ser Ile Ser Gly Gly Ser Ala Val 
        115                 120                 125             
Val Leu Thr Pro Lys Glu Pro Gly Ser Ala Phe Leu Gln Leu Gly Val 
    130                 135                 140                 
Ser Leu Glu Gln Gln Leu Gln Val Leu Phe Lys Val Leu Glu Glu Tyr 
145                 150                 155                 160 
Asp Trp Ser Ala Phe Ala Val Ile Thr Ser Leu His Pro Gly His Ala 
                165                 170                 175     
Leu Phe Leu Glu Gly Val Arg Ala Val Ala Asp Ala Ser His Val Ser 
            180                 185                 190         
Trp Arg Leu Leu Asp Val Val Thr Leu Glu Leu Gly Pro Gly Gly Pro 
        195                 200                 205             
Arg Ala Arg Thr Gln Arg Leu Leu Arg Gln Leu Asp Ala Pro Val Phe 
    210                 215                 220                 
Val Ala Tyr Cys Ser Arg Glu Glu Ala Glu Val Leu Phe Ala Glu Ala 
225                 230                 235                 240 
Ala Gln Ala Gly Leu Val Gly Pro Gly His Val Trp Leu Val Pro Asn 
                245                 250                 255     
Leu Ala Leu Gly Ser Thr Asp Ala Pro Pro Ala Thr Phe Pro Val Gly 
            260                 265                 270         
Leu Ile Ser Val Val Thr Glu Ser Trp Arg Leu Ser Leu Arg Gln Lys 
        275                 280                 285             
Val Arg Asp Gly Val Ala Ile Leu Ala Leu Gly Ala His Ser Tyr Trp 
    290                 295                 300                 
Arg Gln His Gly Thr Leu Pro Ala Pro Ala Gly Asp Cys Arg Val His 
305                 310                 315                 320 
Pro Gly Pro Val Ser Pro Ala Arg Glu Ala Phe Tyr Arg His Leu Leu 
                325                 330                 335     
Asn Val Thr Trp Glu Gly Arg Asp Phe Ser Phe Ser Pro Gly Gly Tyr 
            340                 345                 350         
Leu Val Gln Pro Thr Met Val Val Ile Ala Leu Asn Arg His Arg Leu 
        355                 360                 365             
Trp Glu Met Val Gly Arg Trp Glu His Gly Val Leu Tyr Met Lys Tyr 
    370                 375                 380                 
Pro Val Trp Pro Arg Tyr Ser Ala Ser Leu Gln Pro Val Val Asp Ser 
385                 390                 395                 400 
Arg His Leu Thr Val Ala Thr Leu Glu Glu Arg Pro Phe Val Ile Val 
                405                 410                 415     
Glu Ser Pro Asp Pro Gly Thr Gly Gly Cys Val Pro Asn Thr Val Pro 
            420                 425                 430         
Cys Arg Arg Gln Ser Asn His Thr Phe Ser Ser Gly Asp Val Ala Pro 
        435                 440                 445             
Tyr Thr Lys Leu Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu Lys Lys 
    450                 455                 460                 
Leu Ala Arg Val Val Lys Phe Ser Tyr Asp Leu Tyr Leu Val Thr Asn 
465                 470                 475                 480 
Gly Lys His Gly Lys Arg Val Arg Gly Val Trp Asn Gly Met Ile Gly 
                485                 490                 495     
Glu Val Tyr Tyr Lys Arg Ala Asp Met Ala Ile Gly Ser Leu Thr Ile 
            500                 505                 510         
Asn Glu Glu Arg Ser Glu Ile Val Asp Phe Ser Val Pro Phe Val Glu 
        515                 520                 525             
Thr Gly Ile Ser Val Met Val Ala Arg Ser Asn Gly Thr Val Ser Pro 
    530                 535                 540                 
Ser Ala Phe Leu Glu Pro Tyr Ser Pro Ala Val Trp Val Met Met Phe 
545                 550                 555                 560 
Val Met Cys Leu Thr Val Val Ala Ile Thr Val Phe Met Phe Glu Tyr 
                565                 570                 575     
Phe Ser Pro Val Ser Tyr Asn Gln Asn Leu Thr Arg Gly Lys Lys Ser 
            580                 585                 590         
Gly Gly Pro Ala Phe Thr Ile Gly Lys Ser Val Trp Leu Leu Trp Ala 
        595                 600                 605             
Leu Val Phe Asn Asn Ser Val Pro Ile Glu Asn Pro Arg Gly Thr Thr 
    610                 615                 620                 
Ser Lys Ile Met Val Leu Val Trp Ala Phe Phe Ala Val Ile Phe Leu 
625                 630                 635                 640 
Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu Gln Tyr 
                645                 650                 655     
Ile Asp Thr Val Ser Gly Leu Ser Asp Lys Lys Phe Gln Arg Pro Gln 
            660                 665                 670         
Asp Gln Tyr Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly Ser Thr 
        675                 680                 685             
Glu Arg Asn Ile Arg Ser Asn Tyr Arg Asp Met His Thr His Met Val 
    690                 695                 700                 
Lys Phe Asn Gln Arg Ser Val Glu Asp Ala Leu Thr Ser Leu Lys Met 
705                 710                 715                 720 
Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn Tyr Met 
                725                 730                 735     
Ala Gly Lys Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser Gly Lys 
            740                 745                 750         
Val Phe Ala Thr Thr Gly Tyr Gly Ile Ala Met Gln Lys Asp Ser His 
        755                 760                 765             
Trp Lys Arg Ala Ile Asp Leu Ala Leu Leu Gln Phe Leu Gly Asp Gly 
    770                 775                 780                 
Glu Thr Gln Lys Leu Glu Thr Val Trp Leu Ser Gly Ile Cys Gln Asn 
785                 790                 795                 800 
Glu Lys Asn Glu Val Met Ser Ser Lys Leu Asp Ile Asp Asn Met Ala 
                805                 810                 815     
Gly Val Phe Tyr Met Leu Leu Val Ala Met Gly Leu Ala Leu Leu Val 
            820                 825                 830         
Phe Ala Trp Glu His Leu Val Tyr Trp Lys Leu Arg His Ser Val Pro 
        835                 840                 845             
Asn Ser Ser Gln Leu Asp Phe Leu Leu Ala Phe Ser Arg Gly Ile Tyr 
    850                 855                 860                 
Ser Cys Phe Ser Gly Val Gln Ser Leu Ala Ser Pro Pro Arg Gln Ala 
865                 870                 875                 880 
Ser Pro Asp Leu Thr Ala Ser Ser Ala Gln Ala Ser Val Leu Lys Met 
                885                 890                 895     
Leu Gln Ala Ala Arg Asp Met Val Thr Thr Ala Gly Val Ser Ser Ser 
            900                 905                 910         
Leu Asp Arg Ala Thr Arg Thr Ile Glu Asn Trp Gly Gly Gly Arg Arg 
        915                 920                 925             
Ala Pro Pro Pro Ser Pro Cys Pro Thr Pro Arg Ser Gly Pro Ser Pro 
    930                 935                 940                 
Cys Leu Pro Thr Pro Asp Pro Pro Pro Glu Pro Ser Pro Thr Gly Trp 
945                 950                 955                 960 
Gly Pro Pro Asp Gly Gly Arg Ala Ala Leu Val Arg Arg Ala Pro Gln 
                965                 970                 975     
Pro Pro Gly Arg Pro Pro Thr Pro Gly Pro Pro Leu Ser Asp Val Ser 
            980                 985                 990         
Arg Val Ser Arg Arg Pro Ala Trp Glu Ala Arg Trp Pro Val Arg Thr 
        995                 1000                1005            
Gly His Cys Gly Arg His Leu Ser Ala Ser Glu Arg Pro Leu Ser Pro 
    1010                1015                1020                
Ala Arg Cys His Tyr Ser Ser Phe Pro Arg Ala Asp Arg Ser Gly Arg 
1025                1030                1035                1040
Pro Phe Leu Pro Leu Phe Pro Glu Leu Glu Asp Leu Pro Leu Leu Gly 
                1045                1050                1055    
Pro Glu Gln Leu Ala Arg Arg Glu Ala Leu Leu His Ala Ala Trp Ala 
            1060                1065                1070        
Arg Gly Ser Arg Pro Arg His Ala Ser Leu Pro Ser Ser Val Ala Glu 
        1075                1080                1085            
Ala Phe Ala Arg Pro Ser Ser Leu Pro Ala Gly Cys Thr Gly Pro Ala 
    1090                1095                1100                
Cys Ala Arg Pro Asp Gly His Ser Ala Cys Arg Arg Leu Ala Gln Ala 
1105                1110                1115                1120
Gln Ser Met Cys Leu Pro Ile Tyr Arg Glu Ala Cys Gln Glu Gly Glu 
                1125                1130                1135    
Gln Ala Gly Ala Pro Ala Trp Gln His Arg Gln His Val Cys Leu His 
            1140                1145                1150        
Ala His Ala His Leu Pro Phe Cys Trp Gly Ala Val Cys Pro His Leu 
        1155                1160                1165            
Pro Pro Cys Ala Ser His Gly Ser Trp Leu Ser Gly Ala Trp Gly Pro 
    1170                1175                1180                
Leu Gly His Arg Gly Arg Thr Leu Gly Leu Gly Thr Gly Tyr Arg Asp 
1185                1190                1195                1200
Ser Gly Gly Leu Asp Glu Ile Ser Arg Val Ala Arg Gly Thr Gln Gly 
                1205                1210                1215    
Phe Pro Gly Pro Cys Thr Trp Arg Arg Ile Ser Ser Leu Glu Ser Glu 
            1220                1225                1230        
Val 
    

<210> 34
<211> 362
<212> PRT
<213> Homo sapiens


<220> 
<223> GluN2C ATD

<400> 34
Gln Gly Met Thr Val Ala Val Val Phe Ser Ser Ser Gly Pro Pro Gln 
1               5                   10                  15      
Ala Gln Phe Arg Ala Arg Leu Thr Pro Gln Ser Phe Leu Asp Leu Pro 
            20                  25                  30          
Leu Glu Ile Gln Pro Leu Thr Val Gly Val Asn Thr Thr Asn Pro Ser 
        35                  40                  45              
Ser Leu Leu Thr Gln Ile Cys Gly Leu Leu Gly Ala Ala His Val His 
    50                  55                  60                  
Gly Ile Val Phe Glu Asp Asn Val Asp Thr Glu Ala Val Ala Gln Ile 
65                  70                  75                  80  
Leu Asp Phe Ile Ser Ser Gln Thr His Val Pro Ile Leu Ser Ile Ser 
                85                  90                  95      
Gly Gly Ser Ala Val Val Leu Thr Pro Lys Glu Pro Gly Ser Ala Phe 
            100                 105                 110         
Leu Gln Leu Gly Val Ser Leu Glu Gln Gln Leu Gln Val Leu Phe Lys 
        115                 120                 125             
Val Leu Glu Glu Tyr Asp Trp Ser Ala Phe Ala Val Ile Thr Ser Leu 
    130                 135                 140                 
His Pro Gly His Ala Leu Phe Leu Glu Gly Val Arg Ala Val Ala Asp 
145                 150                 155                 160 
Ala Ser His Val Ser Trp Arg Leu Leu Asp Val Val Thr Leu Glu Leu 
                165                 170                 175     
Gly Pro Gly Gly Pro Arg Ala Arg Thr Gln Arg Leu Leu Arg Gln Leu 
            180                 185                 190         
Asp Ala Pro Val Phe Val Ala Tyr Cys Ser Arg Glu Glu Ala Glu Val 
        195                 200                 205             
Leu Phe Ala Glu Ala Ala Gln Ala Gly Leu Val Gly Pro Gly His Val 
    210                 215                 220                 
Trp Leu Val Pro Asn Leu Ala Leu Gly Ser Thr Asp Ala Pro Pro Ala 
225                 230                 235                 240 
Thr Phe Pro Val Gly Leu Ile Ser Val Val Thr Glu Ser Trp Arg Leu 
                245                 250                 255     
Ser Leu Arg Gln Lys Val Arg Asp Gly Val Ala Ile Leu Ala Leu Gly 
            260                 265                 270         
Ala His Ser Tyr Trp Arg Gln His Gly Thr Leu Pro Ala Pro Ala Gly 
        275                 280                 285             
Asp Cys Arg Val His Pro Gly Pro Val Ser Pro Ala Arg Glu Ala Phe 
    290                 295                 300                 
Tyr Arg His Leu Leu Asn Val Thr Trp Glu Gly Arg Asp Phe Ser Phe 
305                 310                 315                 320 
Ser Pro Gly Gly Tyr Leu Val Gln Pro Thr Met Val Val Ile Ala Leu 
                325                 330                 335     
Asn Arg His Arg Leu Trp Glu Met Val Gly Arg Trp Glu His Gly Val 
            340                 345                 350         
Leu Tyr Met Lys Tyr Pro Val Trp Pro Arg 
        355                 360         

<210> 35
<211> 138
<212> PRT
<213> Homo sapiens


<220> 
<223> GluN2C S1

<400> 35
Ser Arg His Leu Thr Val Ala Thr Leu Glu Glu Arg Pro Phe Val Ile 
1               5                   10                  15      
Val Glu Ser Pro Asp Pro Gly Thr Gly Gly Cys Val Pro Asn Thr Val 
            20                  25                  30          
Pro Cys Arg Arg Gln Ser Asn His Thr Phe Ser Ser Gly Asp Val Ala 
        35                  40                  45              
Pro Tyr Thr Lys Leu Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu Lys 
    50                  55                  60                  
Lys Leu Ala Arg Val Val Lys Phe Ser Tyr Asp Leu Tyr Leu Val Thr 
65                  70                  75                  80  
Asn Gly Lys His Gly Lys Arg Val Arg Gly Val Trp Asn Gly Met Ile 
                85                  90                  95      
Gly Glu Val Tyr Tyr Lys Arg Ala Asp Met Ala Ile Gly Ser Leu Thr 
            100                 105                 110         
Ile Asn Glu Glu Arg Ser Glu Ile Val Asp Phe Ser Val Pro Phe Val 
        115                 120                 125             
Glu Thr Gly Ile Ser Val Met Val Ala Arg 
    130                 135             

<210> 36
<211> 142
<212> PRT
<213> Homo sapiens


<220> 
<223> GluN2C S2

<400> 36
Thr Val Ser Gly Leu Ser Asp Lys Lys Phe Gln Arg Pro Gln Asp Gln 
1               5                   10                  15      
Tyr Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly Ser Thr Glu Arg 
            20                  25                  30          
Asn Ile Arg Ser Asn Tyr Arg Asp Met His Thr His Met Val Lys Phe 
        35                  40                  45              
Asn Gln Arg Ser Val Glu Asp Ala Leu Thr Ser Leu Lys Met Gly Lys 
    50                  55                  60                  
Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn Tyr Met Ala Gly 
65                  70                  75                  80  
Lys Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser Gly Lys Val Phe 
                85                  90                  95      
Ala Thr Thr Gly Tyr Gly Ile Ala Met Gln Lys Asp Ser His Trp Lys 
            100                 105                 110         
Arg Ala Ile Asp Leu Ala Leu Leu Gln Phe Leu Gly Asp Gly Glu Thr 
        115                 120                 125             
Gln Lys Leu Glu Thr Val Trp Leu Ser Gly Ile Cys Gln Asn 
    130                 135                 140         

<210> 37
<211> 681
<212> PRT
<213> Artificial Sequence


<220> 
<223> GluN2C ecd incl. signal sequence and GT-linker between S1 and S2

<400> 37
Met Gly Gly Ala Leu Gly Pro Ala Leu Leu Leu Thr Ser Leu Phe Gly 
1               5                   10                  15      
Ala Trp Ala Gly Leu Gly Pro Gly Gln Gly Glu Gln Gly Met Thr Val 
            20                  25                  30          
Ala Val Val Phe Ser Ser Ser Gly Pro Pro Gln Ala Gln Phe Arg Ala 
        35                  40                  45              
Arg Leu Thr Pro Gln Ser Phe Leu Asp Leu Pro Leu Glu Ile Gln Pro 
    50                  55                  60                  
Leu Thr Val Gly Val Asn Thr Thr Asn Pro Ser Ser Leu Leu Thr Gln 
65                  70                  75                  80  
Ile Cys Gly Leu Leu Gly Ala Ala His Val His Gly Ile Val Phe Glu 
                85                  90                  95      
Asp Asn Val Asp Thr Glu Ala Val Ala Gln Ile Leu Asp Phe Ile Ser 
            100                 105                 110         
Ser Gln Thr His Val Pro Ile Leu Ser Ile Ser Gly Gly Ser Ala Val 
        115                 120                 125             
Val Leu Thr Pro Lys Glu Pro Gly Ser Ala Phe Leu Gln Leu Gly Val 
    130                 135                 140                 
Ser Leu Glu Gln Gln Leu Gln Val Leu Phe Lys Val Leu Glu Glu Tyr 
145                 150                 155                 160 
Asp Trp Ser Ala Phe Ala Val Ile Thr Ser Leu His Pro Gly His Ala 
                165                 170                 175     
Leu Phe Leu Glu Gly Val Arg Ala Val Ala Asp Ala Ser His Val Ser 
            180                 185                 190         
Trp Arg Leu Leu Asp Val Val Thr Leu Glu Leu Gly Pro Gly Gly Pro 
        195                 200                 205             
Arg Ala Arg Thr Gln Arg Leu Leu Arg Gln Leu Asp Ala Pro Val Phe 
    210                 215                 220                 
Val Ala Tyr Cys Ser Arg Glu Glu Ala Glu Val Leu Phe Ala Glu Ala 
225                 230                 235                 240 
Ala Gln Ala Gly Leu Val Gly Pro Gly His Val Trp Leu Val Pro Asn 
                245                 250                 255     
Leu Ala Leu Gly Ser Thr Asp Ala Pro Pro Ala Thr Phe Pro Val Gly 
            260                 265                 270         
Leu Ile Ser Val Val Thr Glu Ser Trp Arg Leu Ser Leu Arg Gln Lys 
        275                 280                 285             
Val Arg Asp Gly Val Ala Ile Leu Ala Leu Gly Ala His Ser Tyr Trp 
    290                 295                 300                 
Arg Gln His Gly Thr Leu Pro Ala Pro Ala Gly Asp Cys Arg Val His 
305                 310                 315                 320 
Pro Gly Pro Val Ser Pro Ala Arg Glu Ala Phe Tyr Arg His Leu Leu 
                325                 330                 335     
Asn Val Thr Trp Glu Gly Arg Asp Phe Ser Phe Ser Pro Gly Gly Tyr 
            340                 345                 350         
Leu Val Gln Pro Thr Met Val Val Ile Ala Leu Asn Arg His Arg Leu 
        355                 360                 365             
Trp Glu Met Val Gly Arg Trp Glu His Gly Val Leu Tyr Met Lys Tyr 
    370                 375                 380                 
Pro Val Trp Pro Arg Tyr Ser Ala Ser Leu Gln Pro Val Val Asp Ser 
385                 390                 395                 400 
Arg His Leu Thr Val Ala Thr Leu Glu Glu Arg Pro Phe Val Ile Val 
                405                 410                 415     
Glu Ser Pro Asp Pro Gly Thr Gly Gly Cys Val Pro Asn Thr Val Pro 
            420                 425                 430         
Cys Arg Arg Gln Ser Asn His Thr Phe Ser Ser Gly Asp Val Ala Pro 
        435                 440                 445             
Tyr Thr Lys Leu Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu Lys Lys 
    450                 455                 460                 
Leu Ala Arg Val Val Lys Phe Ser Tyr Asp Leu Tyr Leu Val Thr Asn 
465                 470                 475                 480 
Gly Lys His Gly Lys Arg Val Arg Gly Val Trp Asn Gly Met Ile Gly 
                485                 490                 495     
Glu Val Tyr Tyr Lys Arg Ala Asp Met Ala Ile Gly Ser Leu Thr Ile 
            500                 505                 510         
Asn Glu Glu Arg Ser Glu Ile Val Asp Phe Ser Val Pro Phe Val Glu 
        515                 520                 525             
Thr Gly Ile Ser Val Met Val Ala Arg Gly Thr Thr Val Ser Gly Leu 
    530                 535                 540                 
Ser Asp Lys Lys Phe Gln Arg Pro Gln Asp Gln Tyr Pro Pro Phe Arg 
545                 550                 555                 560 
Phe Gly Thr Val Pro Asn Gly Ser Thr Glu Arg Asn Ile Arg Ser Asn 
                565                 570                 575     
Tyr Arg Asp Met His Thr His Met Val Lys Phe Asn Gln Arg Ser Val 
            580                 585                 590         
Glu Asp Ala Leu Thr Ser Leu Lys Met Gly Lys Leu Asp Ala Phe Ile 
        595                 600                 605             
Tyr Asp Ala Ala Val Leu Asn Tyr Met Ala Gly Lys Asp Glu Gly Cys 
    610                 615                 620                 
Lys Leu Val Thr Ile Gly Ser Gly Lys Val Phe Ala Thr Thr Gly Tyr 
625                 630                 635                 640 
Gly Ile Ala Met Gln Lys Asp Ser His Trp Lys Arg Ala Ile Asp Leu 
                645                 650                 655     
Ala Leu Leu Gln Phe Leu Gly Asp Gly Glu Thr Gln Lys Leu Glu Thr 
            660                 665                 670         
Val Trp Leu Ser Gly Ile Cys Gln Asn 
        675                 680     

<210> 38
<211> 1336
<212> PRT
<213> Homo sapiens


<220> 
<223> Human GluN2D NP_000827

<400> 38
Met Arg Gly Ala Gly Gly Pro Arg Gly Pro Arg Gly Pro Ala Lys Met 
1               5                   10                  15      
Leu Leu Leu Leu Ala Leu Ala Cys Ala Ser Pro Phe Pro Glu Glu Ala 
            20                  25                  30          
Pro Gly Pro Gly Gly Ala Gly Gly Pro Gly Gly Gly Leu Gly Gly Ala 
        35                  40                  45              
Arg Pro Leu Asn Val Ala Leu Val Phe Ser Gly Pro Ala Tyr Ala Ala 
    50                  55                  60                  
Glu Ala Ala Arg Leu Gly Pro Ala Val Ala Ala Ala Val Arg Ser Pro 
65                  70                  75                  80  
Gly Leu Asp Val Arg Pro Val Ala Leu Val Leu Asn Gly Ser Asp Pro 
                85                  90                  95      
Arg Ser Leu Val Leu Gln Leu Cys Asp Leu Leu Ser Gly Leu Arg Val 
            100                 105                 110         
His Gly Val Val Phe Glu Asp Asp Ser Arg Ala Pro Ala Val Ala Pro 
        115                 120                 125             
Ile Leu Asp Phe Leu Ser Ala Gln Thr Ser Leu Pro Ile Val Ala Val 
    130                 135                 140                 
His Gly Gly Ala Ala Leu Val Leu Thr Pro Lys Glu Lys Gly Ser Thr 
145                 150                 155                 160 
Phe Leu Gln Leu Gly Ser Ser Thr Glu Gln Gln Leu Gln Val Ile Phe 
                165                 170                 175     
Glu Val Leu Glu Glu Tyr Asp Trp Thr Ser Phe Val Ala Val Thr Thr 
            180                 185                 190         
Arg Ala Pro Gly His Arg Ala Phe Leu Ser Tyr Ile Glu Val Leu Thr 
        195                 200                 205             
Asp Gly Ser Leu Val Gly Trp Glu His Arg Gly Ala Leu Thr Leu Asp 
    210                 215                 220                 
Pro Gly Ala Gly Glu Ala Val Leu Ser Ala Gln Leu Arg Ser Val Ser 
225                 230                 235                 240 
Ala Gln Ile Arg Leu Leu Phe Cys Ala Arg Glu Glu Ala Glu Pro Val 
                245                 250                 255     
Phe Arg Ala Ala Glu Glu Ala Gly Leu Thr Gly Ser Gly Tyr Val Trp 
            260                 265                 270         
Phe Met Val Gly Pro Gln Leu Ala Gly Gly Gly Gly Ser Gly Ala Pro 
        275                 280                 285             
Gly Glu Pro Pro Leu Leu Pro Gly Gly Ala Pro Leu Pro Ala Gly Leu 
    290                 295                 300                 
Phe Ala Val Arg Ser Ala Gly Trp Arg Asp Asp Leu Ala Arg Arg Val 
305                 310                 315                 320 
Ala Ala Gly Val Ala Val Val Ala Arg Gly Ala Gln Ala Leu Leu Arg 
                325                 330                 335     
Asp Tyr Gly Phe Leu Pro Glu Leu Gly His Asp Cys Arg Ala Gln Asn 
            340                 345                 350         
Arg Thr His Arg Gly Glu Ser Leu His Arg Tyr Phe Met Asn Ile Thr 
        355                 360                 365             
Trp Asp Asn Arg Asp Tyr Ser Phe Asn Glu Asp Gly Phe Leu Val Asn 
    370                 375                 380                 
Pro Ser Leu Val Val Ile Ser Leu Thr Arg Asp Arg Thr Trp Glu Val 
385                 390                 395                 400 
Val Gly Ser Trp Glu Gln Gln Thr Leu Arg Leu Lys Tyr Pro Leu Trp 
                405                 410                 415     
Ser Arg Tyr Gly Arg Phe Leu Gln Pro Val Asp Asp Thr Gln His Leu 
            420                 425                 430         
Thr Val Ala Thr Leu Glu Glu Arg Pro Phe Val Ile Val Glu Pro Ala 
        435                 440                 445             
Asp Pro Ile Ser Gly Thr Cys Ile Arg Asp Ser Val Pro Cys Arg Ser 
    450                 455                 460                 
Gln Leu Asn Arg Thr His Ser Pro Pro Pro Asp Ala Pro Arg Pro Glu 
465                 470                 475                 480 
Lys Arg Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu Lys Arg Leu Ala 
                485                 490                 495     
His Thr Ile Gly Phe Ser Tyr Asp Leu Tyr Leu Val Thr Asn Gly Lys 
            500                 505                 510         
His Gly Lys Lys Ile Asp Gly Val Trp Asn Gly Met Ile Gly Glu Val 
        515                 520                 525             
Phe Tyr Gln Arg Ala Asp Met Ala Ile Gly Ser Leu Thr Ile Asn Glu 
    530                 535                 540                 
Glu Arg Ser Glu Ile Val Asp Phe Ser Val Pro Phe Val Glu Thr Gly 
545                 550                 555                 560 
Ile Ser Val Met Val Ala Arg Ser Asn Gly Thr Val Ser Pro Ser Ala 
                565                 570                 575     
Phe Leu Glu Pro Tyr Ser Pro Ala Val Trp Val Met Met Phe Val Met 
            580                 585                 590         
Cys Leu Thr Val Val Ala Val Thr Val Phe Ile Phe Glu Tyr Leu Ser 
        595                 600                 605             
Pro Val Gly Tyr Asn Arg Ser Leu Ala Thr Gly Lys Arg Pro Gly Gly 
    610                 615                 620                 
Ser Thr Phe Thr Ile Gly Lys Ser Ile Trp Leu Leu Trp Ala Leu Val 
625                 630                 635                 640 
Phe Asn Asn Ser Val Pro Val Glu Asn Pro Arg Gly Thr Thr Ser Lys 
                645                 650                 655     
Ile Met Val Leu Val Trp Ala Phe Phe Ala Val Ile Phe Leu Ala Ser 
            660                 665                 670         
Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu Glu Tyr Val Asp 
        675                 680                 685             
Thr Val Ser Gly Leu Ser Asp Arg Lys Phe Gln Arg Pro Gln Glu Gln 
    690                 695                 700                 
Tyr Pro Pro Leu Lys Phe Gly Thr Val Pro Asn Gly Ser Thr Glu Lys 
705                 710                 715                 720 
Asn Ile Arg Ser Asn Tyr Pro Asp Met His Ser Tyr Met Val Arg Tyr 
                725                 730                 735     
Asn Gln Pro Arg Val Glu Glu Ala Leu Thr Gln Leu Lys Ala Gly Lys 
            740                 745                 750         
Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn Tyr Met Ala Arg 
        755                 760                 765             
Lys Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser Gly Lys Val Phe 
    770                 775                 780                 
Ala Thr Thr Gly Tyr Gly Ile Ala Leu His Lys Gly Ser Arg Trp Lys 
785                 790                 795                 800 
Arg Pro Ile Asp Leu Ala Leu Leu Gln Phe Leu Gly Asp Asp Glu Ile 
                805                 810                 815     
Glu Met Leu Glu Arg Leu Trp Leu Ser Gly Ile Cys His Asn Asp Lys 
            820                 825                 830         
Ile Glu Val Met Ser Ser Lys Leu Asp Ile Asp Asn Met Ala Gly Val 
        835                 840                 845             
Phe Tyr Met Leu Leu Val Ala Met Gly Leu Ser Leu Leu Val Phe Ala 
    850                 855                 860                 
Trp Glu His Leu Val Tyr Trp Arg Leu Arg His Cys Leu Gly Pro Thr 
865                 870                 875                 880 
His Arg Met Asp Phe Leu Leu Ala Phe Ser Arg Gly Met Tyr Ser Cys 
                885                 890                 895     
Cys Ser Ala Glu Ala Ala Pro Pro Pro Ala Lys Pro Pro Pro Pro Pro 
            900                 905                 910         
Gln Pro Leu Pro Ser Pro Ala Tyr Pro Ala Pro Arg Pro Ala Pro Gly 
        915                 920                 925             
Pro Ala Pro Phe Val Pro Arg Glu Arg Ala Ser Val Asp Arg Trp Arg 
    930                 935                 940                 
Arg Thr Lys Gly Ala Gly Pro Pro Gly Gly Ala Gly Leu Ala Asp Gly 
945                 950                 955                 960 
Phe His Arg Tyr Tyr Gly Pro Ile Glu Pro Gln Gly Leu Gly Leu Gly 
                965                 970                 975     
Leu Gly Glu Ala Arg Ala Ala Pro Arg Gly Ala Ala Gly Arg Pro Leu 
            980                 985                 990         
Ser Pro Pro Ala Ala Gln Pro Pro Gln Lys Pro Pro Pro Ser Tyr Phe 
        995                 1000                1005            
Ala Ile Val Arg Asp Lys Glu Pro Ala Glu Pro Pro Ala Gly Ala Phe 
    1010                1015                1020                
Pro Gly Phe Pro Ser Pro Pro Ala Pro Pro Ala Ala Ala Ala Thr Ala 
1025                1030                1035                1040
Val Gly Pro Pro Leu Cys Arg Leu Ala Phe Glu Asp Glu Ser Pro Pro 
                1045                1050                1055    
Ala Pro Ala Arg Trp Pro Arg Ser Asp Pro Glu Ser Gln Pro Leu Leu 
            1060                1065                1070        
Gly Pro Gly Ala Gly Gly Ala Gly Gly Thr Gly Gly Ala Gly Gly Gly 
        1075                1080                1085            
Ala Pro Ala Ala Pro Pro Pro Cys Arg Ala Ala Pro Pro Pro Cys Pro 
    1090                1095                1100                
Tyr Leu Asp Leu Glu Pro Ser Pro Ser Asp Ser Glu Asp Ser Glu Ser 
1105                1110                1115                1120
Leu Gly Gly Ala Ser Leu Gly Gly Leu Glu Pro Trp Trp Phe Ala Asp 
                1125                1130                1135    
Phe Pro Tyr Pro Tyr Ala Glu Arg Leu Gly Pro Pro Pro Gly Arg Tyr 
            1140                1145                1150        
Trp Ser Val Asp Lys Leu Gly Gly Trp Arg Ala Gly Ser Trp Asp Tyr 
        1155                1160                1165            
Leu Pro Pro Arg Ser Gly Pro Ala Ala Trp His Cys Arg His Cys Ala 
    1170                1175                1180                
Ser Leu Glu Leu Leu Pro Pro Pro Arg His Leu Ser Cys Ser His Asp 
1185                1190                1195                1200
Gly Leu Asp Gly Gly Trp Trp Ala Pro Pro Pro Pro Pro Trp Ala Ala 
                1205                1210                1215    
Gly Pro Leu Pro Arg Arg Arg Ala Arg Cys Gly Cys Pro Arg Ser His 
            1220                1225                1230        
Pro His Arg Pro Arg Ala Ser His Arg Thr Pro Ala Ala Ala Ala Pro 
        1235                1240                1245            
His His His Arg His Arg Arg Ala Ala Gly Gly Trp Asp Leu Pro Pro 
    1250                1255                1260                
Pro Ala Pro Thr Ser Arg Ser Leu Glu Asp Leu Ser Ser Cys Pro Arg 
1265                1270                1275                1280
Ala Ala Pro Ala Arg Arg Leu Thr Gly Pro Ser Arg His Ala Arg Arg 
                1285                1290                1295    
Cys Pro His Ala Ala His Trp Gly Pro Pro Leu Pro Thr Ala Ser His 
            1300                1305                1310        
Arg Arg His Arg Gly Gly Asp Leu Gly Thr Arg Arg Gly Ser Ala His 
        1315                1320                1325            
Phe Ser Ser Leu Glu Ser Glu Val 
    1330                1335    

<210> 39
<211> 1336
<212> PRT
<213> Homo sapiens


<220> 
<223> Human GluN2D Protein seq U77783

<400> 39
Met Arg Gly Ala Gly Gly Pro Arg Gly Pro Arg Gly Pro Ala Lys Met 
1               5                   10                  15      
Leu Leu Leu Leu Ala Leu Ala Cys Ala Ser Pro Phe Pro Glu Glu Ala 
            20                  25                  30          
Pro Gly Pro Gly Gly Ala Gly Gly Pro Gly Gly Gly Leu Gly Gly Ala 
        35                  40                  45              
Arg Pro Leu Asn Val Ala Leu Val Phe Ser Gly Pro Ala Tyr Ala Ala 
    50                  55                  60                  
Glu Ala Ala Arg Leu Gly Pro Ala Val Ala Ala Ala Val Arg Ser Pro 
65                  70                  75                  80  
Gly Leu Asp Val Arg Pro Val Ala Leu Val Leu Asn Gly Ser Asp Pro 
                85                  90                  95      
Arg Ser Leu Val Leu Gln Leu Cys Asp Leu Leu Ser Gly Leu Arg Val 
            100                 105                 110         
His Gly Val Val Phe Glu Asp Asp Ser Arg Ala Pro Ala Val Ala Pro 
        115                 120                 125             
Ile Leu Asp Phe Leu Ser Ala Gln Thr Ser Leu Pro Ile Val Ala Val 
    130                 135                 140                 
His Gly Gly Ala Ala Leu Val Leu Thr Pro Lys Glu Lys Gly Ser Thr 
145                 150                 155                 160 
Phe Leu Gln Leu Gly Ser Ser Thr Glu Gln Gln Leu Gln Val Ile Phe 
                165                 170                 175     
Glu Val Leu Glu Glu Tyr Asp Trp Thr Ser Phe Val Ala Val Thr Thr 
            180                 185                 190         
Arg Ala Pro Gly His Arg Ala Phe Leu Ser Tyr Ile Glu Val Leu Thr 
        195                 200                 205             
Asp Gly Ser Leu Val Gly Trp Glu His Arg Gly Ala Leu Thr Leu Asp 
    210                 215                 220                 
Pro Gly Ala Gly Glu Ala Val Leu Ser Ala Gln Leu Arg Ser Val Ser 
225                 230                 235                 240 
Ala Gln Ile Arg Leu Leu Phe Cys Ala Arg Glu Glu Ala Glu Pro Val 
                245                 250                 255     
Phe Arg Ala Ala Glu Glu Ala Gly Leu Thr Gly Ser Gly Tyr Val Trp 
            260                 265                 270         
Phe Met Val Gly Pro Gln Leu Ala Gly Gly Gly Gly Ser Gly Ala Pro 
        275                 280                 285             
Gly Glu Pro Pro Leu Leu Pro Gly Gly Ala Pro Leu Pro Ala Gly Leu 
    290                 295                 300                 
Phe Ala Val Arg Ser Ala Gly Trp Arg Asp Asp Leu Ala Arg Arg Val 
305                 310                 315                 320 
Ala Ala Gly Val Ala Val Val Ala Arg Gly Ala Gln Ala Leu Leu Arg 
                325                 330                 335     
Asp Tyr Gly Phe Leu Pro Glu Leu Gly His Asp Cys Arg Ala Gln Asn 
            340                 345                 350         
Arg Thr His Arg Gly Glu Ser Leu His Arg Tyr Phe Met Asn Ile Thr 
        355                 360                 365             
Trp Asp Asn Arg Asp Tyr Ser Phe Asn Glu Asp Gly Phe Leu Val Asn 
    370                 375                 380                 
Pro Ser Leu Val Val Ile Ser Leu Thr Arg Asp Arg Thr Trp Glu Val 
385                 390                 395                 400 
Val Gly Ser Trp Glu Gln Gln Thr Leu Arg Leu Lys Tyr Pro Leu Trp 
                405                 410                 415     
Ser Arg Tyr Gly Arg Phe Leu Gln Pro Val Asp Asp Thr Gln His Leu 
            420                 425                 430         
Thr Val Ala Thr Leu Glu Glu Arg Pro Phe Val Ile Val Glu Pro Ala 
        435                 440                 445             
Asp Pro Ile Ser Gly Thr Cys Ile Arg Asp Ser Val Pro Cys Arg Ser 
    450                 455                 460                 
Gln Leu Asn Arg Thr His Ser Pro Pro Pro Asp Ala Pro Arg Pro Glu 
465                 470                 475                 480 
Lys Arg Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu Lys Arg Leu Ala 
                485                 490                 495     
His Thr Ile Gly Phe Ser Tyr Asp Leu Tyr Leu Val Thr Asn Gly Lys 
            500                 505                 510         
His Gly Lys Lys Ile Asp Gly Val Trp Asn Gly Met Ile Gly Glu Val 
        515                 520                 525             
Phe Tyr Gln Arg Ala Asp Met Ala Ile Gly Ser Leu Thr Ile Asn Glu 
    530                 535                 540                 
Glu Arg Ser Glu Ile Val Asp Phe Ser Val Pro Phe Val Glu Thr Gly 
545                 550                 555                 560 
Ile Ser Val Met Val Ala Arg Ser Asn Gly Thr Val Ser Pro Ser Ala 
                565                 570                 575     
Phe Leu Glu Pro Tyr Ser Pro Ala Val Trp Val Met Met Phe Val Met 
            580                 585                 590         
Cys Leu Thr Val Val Ala Val Thr Val Phe Ile Phe Glu Tyr Leu Ser 
        595                 600                 605             
Pro Val Gly Tyr Asn Arg Ser Leu Ala Thr Gly Lys Arg Pro Gly Gly 
    610                 615                 620                 
Ser Thr Phe Thr Ile Gly Lys Ser Ile Trp Leu Leu Trp Ala Leu Val 
625                 630                 635                 640 
Phe Asn Asn Ser Val Pro Val Glu Asn Pro Arg Gly Thr Thr Ser Lys 
                645                 650                 655     
Ile Met Val Leu Val Trp Ala Phe Phe Ala Val Ile Phe Leu Ala Ser 
            660                 665                 670         
Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu Glu Tyr Val Asp 
        675                 680                 685             
Thr Val Ser Gly Leu Ser Asp Arg Lys Phe Gln Arg Pro Gln Glu Gln 
    690                 695                 700                 
Tyr Pro Pro Leu Lys Phe Gly Thr Val Pro Asn Gly Ser Thr Glu Lys 
705                 710                 715                 720 
Asn Ile Arg Ser Asn Tyr Pro Asp Met His Ser Tyr Met Val Arg Tyr 
                725                 730                 735     
Asn Gln Pro Arg Val Glu Glu Ala Leu Thr Gln Leu Lys Ala Gly Lys 
            740                 745                 750         
Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn Tyr Met Ala Arg 
        755                 760                 765             
Lys Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser Gly Lys Val Phe 
    770                 775                 780                 
Ala Thr Thr Gly Tyr Gly Ile Ala Leu His Lys Gly Ser Arg Trp Lys 
785                 790                 795                 800 
Arg Pro Ile Asp Leu Ala Leu Leu Gln Phe Leu Gly Asp Asp Glu Ile 
                805                 810                 815     
Glu Met Leu Glu Arg Leu Trp Leu Ser Gly Ile Cys His Asn Asp Lys 
            820                 825                 830         
Ile Glu Val Met Ser Ser Lys Leu Asp Ile Asp Asn Met Ala Gly Val 
        835                 840                 845             
Phe Tyr Met Leu Leu Val Ala Met Gly Leu Ser Leu Leu Val Phe Ala 
    850                 855                 860                 
Trp Glu His Leu Val Tyr Trp Arg Leu Arg His Cys Leu Gly Pro Thr 
865                 870                 875                 880 
His Arg Met Asp Phe Leu Leu Ala Phe Ser Arg Gly Met Tyr Ser Cys 
                885                 890                 895     
Cys Ser Ala Glu Ala Ala Pro Pro Pro Ala Lys Pro Pro Pro Pro Pro 
            900                 905                 910         
Gln Pro Leu Pro Ser Pro Ala Tyr Pro Ala Pro Gly Pro Ala Pro Gly 
        915                 920                 925             
Pro Ala Pro Phe Val Pro Arg Glu Arg Ala Ser Val Asp Arg Trp Arg 
    930                 935                 940                 
Arg Thr Lys Gly Ala Gly Pro Pro Gly Gly Ala Gly Leu Ala Asp Gly 
945                 950                 955                 960 
Phe His Arg Tyr Tyr Gly Pro Ile Glu Pro Gln Gly Leu Gly Leu Gly 
                965                 970                 975     
Leu Gly Glu Ala Arg Ala Ala Pro Arg Gly Ala Ala Gly Arg Pro Leu 
            980                 985                 990         
Ser Pro Pro Ala Ala Gln Pro Pro Gln Lys Pro Pro Ala Ser Tyr Phe 
        995                 1000                1005            
Ala Ile Val Arg Asp Lys Glu Pro Ala Glu Pro Pro Ala Gly Ala Phe 
    1010                1015                1020                
Pro Gly Phe Pro Ser Pro Pro Ala Pro Pro Ala Ala Ala Ala Thr Ala 
1025                1030                1035                1040
Val Gly Pro Pro Leu Cys Arg Leu Ala Phe Glu Asp Glu Ser Pro Pro 
                1045                1050                1055    
Ala Pro Ala Arg Trp Pro Arg Ser Asp Pro Glu Ser Gln Pro Leu Leu 
            1060                1065                1070        
Gly Pro Gly Ala Gly Gly Ala Gly Gly Thr Gly Gly Ala Gly Gly Gly 
        1075                1080                1085            
Ala Pro Ala Ala Pro Pro Pro Cys Cys Ala Ala Pro Pro Pro Cys Pro 
    1090                1095                1100                
Tyr Leu Asp Leu Glu Pro Ser Pro Ser Asp Ser Glu Asp Ser Glu Ser 
1105                1110                1115                1120
Leu Gly Gly Ala Ser Leu Gly Gly Leu Asp Pro Trp Trp Phe Ala Asp 
                1125                1130                1135    
Phe Pro Tyr Pro Tyr Ala Glu Arg Leu Gly Pro Pro Pro Gly Arg Tyr 
            1140                1145                1150        
Trp Ser Val Asp Lys Leu Gly Gly Trp Arg Ala Gly Ser Trp Asp Tyr 
        1155                1160                1165            
Leu Pro Pro Arg Ser Gly Pro Ala Ala Trp His Cys Arg His Cys Ala 
    1170                1175                1180                
Ser Leu Glu Leu Leu Pro Pro Pro Arg His Leu Ser Cys Ser His Asp 
1185                1190                1195                1200
Gly Leu Asp Gly Gly Trp Trp Ala Pro Pro Pro Pro Pro Trp Ala Ala 
                1205                1210                1215    
Gly Pro Leu Pro Arg Arg Arg Ala Arg Cys Gly Cys Pro Arg Ser His 
            1220                1225                1230        
Pro His Arg Pro Arg Ala Ser His Arg Thr Pro Ala Ala Ala Ala Pro 
        1235                1240                1245            
His His His Arg His Arg Arg Ala Ala Gly Gly Trp Asp Leu Pro Pro 
    1250                1255                1260                
Pro Ala Pro Thr Ser Arg Ser Leu Glu Asp Leu Ser Ser Cys Pro Arg 
1265                1270                1275                1280
Ala Ala Pro Ala Arg Arg Leu Thr Gly Pro Ser Arg His Ala Arg Arg 
                1285                1290                1295    
Cys Pro His Ala Ala His Trp Gly Pro Pro Leu Pro Thr Ala Ser His 
            1300                1305                1310        
Arg Arg His Arg Gly Gly Asp Leu Gly Thr Arg Arg Gly Ser Ala His 
        1315                1320                1325            
Phe Ser Ser Leu Glu Ser Glu Val 
    1330                1335    

<210> 40
<211> 370
<212> PRT
<213> Homo sapiens


<220> 
<223> GluN2D ATD

<400> 40
Arg Pro Leu Asn Val Ala Leu Val Phe Ser Gly Pro Ala Tyr Ala Ala 
1               5                   10                  15      
Glu Ala Ala Arg Leu Gly Pro Ala Val Ala Ala Ala Val Arg Ser Pro 
            20                  25                  30          
Gly Leu Asp Val Arg Pro Val Ala Leu Val Leu Asn Gly Ser Asp Pro 
        35                  40                  45              
Arg Ser Leu Val Leu Gln Leu Cys Asp Leu Leu Ser Gly Leu Arg Val 
    50                  55                  60                  
His Gly Val Val Phe Glu Asp Asp Ser Arg Ala Pro Ala Val Ala Pro 
65                  70                  75                  80  
Ile Leu Asp Phe Leu Ser Ala Gln Thr Ser Leu Pro Ile Val Ala Val 
                85                  90                  95      
His Gly Gly Ala Ala Leu Val Leu Thr Pro Lys Glu Lys Gly Ser Thr 
            100                 105                 110         
Phe Leu Gln Leu Gly Ser Ser Thr Glu Gln Gln Leu Gln Val Ile Phe 
        115                 120                 125             
Glu Val Leu Glu Glu Tyr Asp Trp Thr Ser Phe Val Ala Val Thr Thr 
    130                 135                 140                 
Arg Ala Pro Gly His Arg Ala Phe Leu Ser Tyr Ile Glu Val Leu Thr 
145                 150                 155                 160 
Asp Gly Ser Leu Val Gly Trp Glu His Arg Gly Ala Leu Thr Leu Asp 
                165                 170                 175     
Pro Gly Ala Gly Glu Ala Val Leu Ser Ala Gln Leu Arg Ser Val Ser 
            180                 185                 190         
Ala Gln Ile Arg Leu Leu Phe Cys Ala Arg Glu Glu Ala Glu Pro Val 
        195                 200                 205             
Phe Arg Ala Ala Glu Glu Ala Gly Leu Thr Gly Ser Gly Tyr Val Trp 
    210                 215                 220                 
Phe Met Val Gly Pro Gln Leu Ala Gly Gly Gly Gly Ser Gly Ala Pro 
225                 230                 235                 240 
Gly Glu Pro Pro Leu Leu Pro Gly Gly Ala Pro Leu Pro Ala Gly Leu 
                245                 250                 255     
Phe Ala Val Arg Ser Ala Gly Trp Arg Asp Asp Leu Ala Arg Arg Val 
            260                 265                 270         
Ala Ala Gly Val Ala Val Val Ala Arg Gly Ala Gln Ala Leu Leu Arg 
        275                 280                 285             
Asp Tyr Gly Phe Leu Pro Glu Leu Gly His Asp Cys Arg Ala Gln Asn 
    290                 295                 300                 
Arg Thr His Arg Gly Glu Ser Leu His Arg Tyr Phe Met Asn Ile Thr 
305                 310                 315                 320 
Trp Asp Asn Arg Asp Tyr Ser Phe Asn Glu Asp Gly Phe Leu Val Asn 
                325                 330                 335     
Pro Ser Leu Val Val Ile Ser Leu Thr Arg Asp Arg Thr Trp Glu Val 
            340                 345                 350         
Val Gly Ser Trp Glu Gln Gln Thr Leu Arg Leu Lys Tyr Pro Leu Trp 
        355                 360                 365             
Ser Arg 
    370 

<210> 41
<211> 139
<212> PRT
<213> Homo sapiens


<220> 
<223> GluN2D S1

<400> 41
Thr Gln His Leu Thr Val Ala Thr Leu Glu Glu Arg Pro Phe Val Ile 
1               5                   10                  15      
Val Glu Pro Ala Asp Pro Ile Ser Gly Thr Cys Ile Arg Asp Ser Val 
            20                  25                  30          
Pro Cys Arg Ser Gln Leu Asn Arg Thr His Ser Pro Pro Pro Asp Ala 
        35                  40                  45              
Pro Arg Pro Glu Lys Arg Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu 
    50                  55                  60                  
Lys Arg Leu Ala His Thr Ile Gly Phe Ser Tyr Asp Leu Tyr Leu Val 
65                  70                  75                  80  
Thr Asn Gly Lys His Gly Lys Lys Ile Asp Gly Val Trp Asn Gly Met 
                85                  90                  95      
Ile Gly Glu Val Phe Tyr Gln Arg Ala Asp Met Ala Ile Gly Ser Leu 
            100                 105                 110         
Thr Ile Asn Glu Glu Arg Ser Glu Ile Val Asp Phe Ser Val Pro Phe 
        115                 120                 125             
Val Glu Thr Gly Ile Ser Val Met Val Ala Arg 
    130                 135                 

<210> 42
<211> 142
<212> PRT
<213> Homo sapiens


<220> 
<223> GluN2D S2

<400> 42
Thr Val Ser Gly Leu Ser Asp Arg Lys Phe Gln Arg Pro Gln Glu Gln 
1               5                   10                  15      
Tyr Pro Pro Leu Lys Phe Gly Thr Val Pro Asn Gly Ser Thr Glu Lys 
            20                  25                  30          
Asn Ile Arg Ser Asn Tyr Pro Asp Met His Ser Tyr Met Val Arg Tyr 
        35                  40                  45              
Asn Gln Pro Arg Val Glu Glu Ala Leu Thr Gln Leu Lys Ala Gly Lys 
    50                  55                  60                  
Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn Tyr Met Ala Arg 
65                  70                  75                  80  
Lys Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser Gly Lys Val Phe 
                85                  90                  95      
Ala Thr Thr Gly Tyr Gly Ile Ala Leu His Lys Gly Ser Arg Trp Lys 
            100                 105                 110         
Arg Pro Ile Asp Leu Ala Leu Leu Gln Phe Leu Gly Asp Asp Glu Ile 
        115                 120                 125             
Glu Met Leu Glu Arg Leu Trp Leu Ser Gly Ile Cys His Asn 
    130                 135                 140         

<210> 43
<211> 711
<212> PRT
<213> Artificial Sequence


<220> 
<223> GluN2D ecd incl. signal sequence and GT-linker between S1 and S2

<400> 43
Met Arg Gly Ala Gly Gly Pro Arg Gly Pro Arg Gly Pro Ala Lys Met 
1               5                   10                  15      
Leu Leu Leu Leu Ala Leu Ala Cys Ala Ser Pro Phe Pro Glu Glu Ala 
            20                  25                  30          
Pro Gly Pro Gly Gly Ala Gly Gly Pro Gly Gly Gly Leu Gly Gly Ala 
        35                  40                  45              
Arg Pro Leu Asn Val Ala Leu Val Phe Ser Gly Pro Ala Tyr Ala Ala 
    50                  55                  60                  
Glu Ala Ala Arg Leu Gly Pro Ala Val Ala Ala Ala Val Arg Ser Pro 
65                  70                  75                  80  
Gly Leu Asp Val Arg Pro Val Ala Leu Val Leu Asn Gly Ser Asp Pro 
                85                  90                  95      
Arg Ser Leu Val Leu Gln Leu Cys Asp Leu Leu Ser Gly Leu Arg Val 
            100                 105                 110         
His Gly Val Val Phe Glu Asp Asp Ser Arg Ala Pro Ala Val Ala Pro 
        115                 120                 125             
Ile Leu Asp Phe Leu Ser Ala Gln Thr Ser Leu Pro Ile Val Ala Val 
    130                 135                 140                 
His Gly Gly Ala Ala Leu Val Leu Thr Pro Lys Glu Lys Gly Ser Thr 
145                 150                 155                 160 
Phe Leu Gln Leu Gly Ser Ser Thr Glu Gln Gln Leu Gln Val Ile Phe 
                165                 170                 175     
Glu Val Leu Glu Glu Tyr Asp Trp Thr Ser Phe Val Ala Val Thr Thr 
            180                 185                 190         
Arg Ala Pro Gly His Arg Ala Phe Leu Ser Tyr Ile Glu Val Leu Thr 
        195                 200                 205             
Asp Gly Ser Leu Val Gly Trp Glu His Arg Gly Ala Leu Thr Leu Asp 
    210                 215                 220                 
Pro Gly Ala Gly Glu Ala Val Leu Ser Ala Gln Leu Arg Ser Val Ser 
225                 230                 235                 240 
Ala Gln Ile Arg Leu Leu Phe Cys Ala Arg Glu Glu Ala Glu Pro Val 
                245                 250                 255     
Phe Arg Ala Ala Glu Glu Ala Gly Leu Thr Gly Ser Gly Tyr Val Trp 
            260                 265                 270         
Phe Met Val Gly Pro Gln Leu Ala Gly Gly Gly Gly Ser Gly Ala Pro 
        275                 280                 285             
Gly Glu Pro Pro Leu Leu Pro Gly Gly Ala Pro Leu Pro Ala Gly Leu 
    290                 295                 300                 
Phe Ala Val Arg Ser Ala Gly Trp Arg Asp Asp Leu Ala Arg Arg Val 
305                 310                 315                 320 
Ala Ala Gly Val Ala Val Val Ala Arg Gly Ala Gln Ala Leu Leu Arg 
                325                 330                 335     
Asp Tyr Gly Phe Leu Pro Glu Leu Gly His Asp Cys Arg Ala Gln Asn 
            340                 345                 350         
Arg Thr His Arg Gly Glu Ser Leu His Arg Tyr Phe Met Asn Ile Thr 
        355                 360                 365             
Trp Asp Asn Arg Asp Tyr Ser Phe Asn Glu Asp Gly Phe Leu Val Asn 
    370                 375                 380                 
Pro Ser Leu Val Val Ile Ser Leu Thr Arg Asp Arg Thr Trp Glu Val 
385                 390                 395                 400 
Val Gly Ser Trp Glu Gln Gln Thr Leu Arg Leu Lys Tyr Pro Leu Trp 
                405                 410                 415     
Ser Arg Tyr Gly Arg Phe Leu Gln Pro Val Asp Asp Thr Gln His Leu 
            420                 425                 430         
Thr Val Ala Thr Leu Glu Glu Arg Pro Phe Val Ile Val Glu Pro Ala 
        435                 440                 445             
Asp Pro Ile Ser Gly Thr Cys Ile Arg Asp Ser Val Pro Cys Arg Ser 
    450                 455                 460                 
Gln Leu Asn Arg Thr His Ser Pro Pro Pro Asp Ala Pro Arg Pro Glu 
465                 470                 475                 480 
Lys Arg Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu Lys Arg Leu Ala 
                485                 490                 495     
His Thr Ile Gly Phe Ser Tyr Asp Leu Tyr Leu Val Thr Asn Gly Lys 
            500                 505                 510         
His Gly Lys Lys Ile Asp Gly Val Trp Asn Gly Met Ile Gly Glu Val 
        515                 520                 525             
Phe Tyr Gln Arg Ala Asp Met Ala Ile Gly Ser Leu Thr Ile Asn Glu 
    530                 535                 540                 
Glu Arg Ser Glu Ile Val Asp Phe Ser Val Pro Phe Val Glu Thr Gly 
545                 550                 555                 560 
Ile Ser Val Met Val Ala Arg Gly Thr Thr Val Ser Gly Leu Ser Asp 
                565                 570                 575     
Arg Lys Phe Gln Arg Pro Gln Glu Gln Tyr Pro Pro Leu Lys Phe Gly 
            580                 585                 590         
Thr Val Pro Asn Gly Ser Thr Glu Lys Asn Ile Arg Ser Asn Tyr Pro 
        595                 600                 605             
Asp Met His Ser Tyr Met Val Arg Tyr Asn Gln Pro Arg Val Glu Glu 
    610                 615                 620                 
Ala Leu Thr Gln Leu Lys Ala Gly Lys Leu Asp Ala Phe Ile Tyr Asp 
625                 630                 635                 640 
Ala Ala Val Leu Asn Tyr Met Ala Arg Lys Asp Glu Gly Cys Lys Leu 
                645                 650                 655     
Val Thr Ile Gly Ser Gly Lys Val Phe Ala Thr Thr Gly Tyr Gly Ile 
            660                 665                 670         
Ala Leu His Lys Gly Ser Arg Trp Lys Arg Pro Ile Asp Leu Ala Leu 
        675                 680                 685             
Leu Gln Phe Leu Gly Asp Asp Glu Ile Glu Met Leu Glu Arg Leu Trp 
    690                 695                 700                 
Leu Ser Gly Ile Cys His Asn 
705                 710     

<210> 44
<211> 1464
<212> PRT
<213> Homo sapiens


<220> 
<223> Human GluN2A NM_001134407

<400> 44
Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu 
1               5                   10                  15      
Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro 
            20                  25                  30          
Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu 
        35                  40                  45              
Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro 
    50                  55                  60                  
Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys 
65                  70                  75                  80  
Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His 
                85                  90                  95      
Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met 
            100                 105                 110         
Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His 
        115                 120                 125             
Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe 
    130                 135                 140                 
Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys 
145                 150                 155                 160 
Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile 
                165                 170                 175     
Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp 
            180                 185                 190         
Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr 
        195                 200                 205             
Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser 
    210                 215                 220                 
Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu 
225                 230                 235                 240 
Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile 
                245                 250                 255     
Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe 
            260                 265                 270         
Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu 
        275                 280                 285             
Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser 
    290                 295                 300                 
Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys 
305                 310                 315                 320 
Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro 
                325                 330                 335     
Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu 
            340                 345                 350         
Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys 
        355                 360                 365             
Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser 
    370                 375                 380                 
Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu 
385                 390                 395                 400 
Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     
Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn 
            420                 425                 430         
Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu 
        435                 440                 445             
Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu 
    450                 455                 460                 
Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val 
465                 470                 475                 480 
Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met 
                485                 490                 495     
Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu 
            500                 505                 510         
Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe 
        515                 520                 525             
Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr Val 
    530                 535                 540                 
Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser Val Trp Val Met 
545                 550                 555                 560 
Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala Val Phe Val Phe 
                565                 570                 575     
Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Asn Leu Ala Lys Gly Lys 
            580                 585                 590         
Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu Leu 
        595                 600                 605             
Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys Gly 
    610                 615                 620                 
Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val Ile 
625                 630                 635                 640 
Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu 
                645                 650                 655     
Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg 
            660                 665                 670         
Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly 
        675                 680                 685             
Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr 
    690                 695                 700                 
Met Thr Lys Phe Asn Gln Lys Gly Val Glu Asp Ala Leu Val Ser Leu 
705                 710                 715                 720 
Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn 
                725                 730                 735     
Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser 
            740                 745                 750         
Gly Tyr Ile Phe Ala Thr Thr Gly Tyr Gly Ile Ala Leu Gln Lys Gly 
        755                 760                 765             
Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly 
    770                 775                 780                 
Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Cys 
785                 790                 795                 800 
His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp Asn 
                805                 810                 815     
Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met Ala Leu Ser Leu 
            820                 825                 830         
Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys Leu Arg Phe Cys 
        835                 840                 845             
Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser 
    850                 855                 860                 
Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys 
865                 870                 875                 880 
Lys Ser Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys 
                885                 890                 895     
Leu Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser Asn Met Asn Ser 
            900                 905                 910         
Ser Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe Ile Gln Arg Gly 
        915                 920                 925             
Ser Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn Leu Met Tyr Ser 
    930                 935                 940                 
Asp Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe Gly Asp Asn Met 
945                 950                 955                 960 
Asn Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys Asp Asn Leu Asn 
                965                 970                 975     
Asn Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn 
            980                 985                 990         
Pro Asn Thr Val Glu Val Ala Val Ser Thr Glu Ser Lys Ala Asn Ser 
        995                 1000                1005            
Arg Pro Arg Gln Leu Trp Lys Lys Ser Val Asp Ser Ile Arg Gln Asp 
    1010                1015                1020                
Ser Leu Ser Gln Asn Pro Val Ser Gln Arg Asp Glu Ala Thr Ala Glu 
1025                1030                1035                1040
Asn Arg Thr His Ser Leu Lys Ser Pro Arg Tyr Leu Pro Glu Glu Met 
                1045                1050                1055    
Ala His Ser Asp Ile Ser Glu Thr Ser Asn Arg Ala Thr Cys His Arg 
            1060                1065                1070        
Glu Pro Asp Asn Ser Lys Asn His Lys Thr Lys Asp Asn Phe Lys Arg 
        1075                1080                1085            
Ser Val Ala Ser Lys Tyr Pro Lys Asp Cys Ser Glu Val Glu Arg Thr 
    1090                1095                1100                
Tyr Leu Lys Thr Lys Ser Ser Ser Pro Arg Asp Lys Ile Tyr Thr Ile 
1105                1110                1115                1120
Asp Gly Glu Lys Glu Pro Gly Phe His Leu Asp Pro Pro Gln Phe Val 
                1125                1130                1135    
Glu Asn Val Thr Leu Pro Glu Asn Val Asp Phe Pro Asp Pro Tyr Gln 
            1140                1145                1150        
Asp Pro Ser Glu Asn Phe Arg Lys Gly Asp Ser Thr Leu Pro Met Asn 
        1155                1160                1165            
Arg Asn Pro Leu His Asn Glu Glu Gly Leu Ser Asn Asn Asp Gln Tyr 
    1170                1175                1180                
Lys Leu Tyr Ser Lys His Phe Thr Leu Lys Asp Lys Gly Ser Pro His 
1185                1190                1195                1200
Ser Glu Thr Ser Glu Arg Tyr Arg Gln Asn Ser Thr His Cys Arg Ser 
                1205                1210                1215    
Cys Leu Ser Asn Met Pro Thr Tyr Ser Gly His Phe Thr Met Arg Ser 
            1220                1225                1230        
Pro Phe Lys Cys Asp Ala Cys Leu Arg Met Gly Asn Leu Tyr Asp Ile 
        1235                1240                1245            
Asp Glu Asp Gln Met Leu Gln Glu Thr Gly Asn Pro Ala Thr Gly Glu 
    1250                1255                1260                
Gln Val Tyr Gln Gln Asp Trp Ala Gln Asn Asn Ala Leu Gln Leu Gln 
1265                1270                1275                1280
Lys Asn Lys Leu Arg Ile Ser Arg Gln His Ser Tyr Asp Asn Ile Val 
                1285                1290                1295    
Asp Lys Pro Arg Glu Leu Asp Leu Ser Arg Pro Ser Arg Ser Ile Ser 
            1300                1305                1310        
Leu Lys Asp Arg Glu Arg Leu Leu Glu Gly Asn Phe Tyr Gly Ser Leu 
        1315                1320                1325            
Phe Ser Val Pro Ser Ser Lys Leu Ser Gly Lys Lys Ser Ser Leu Phe 
    1330                1335                1340                
Pro Gln Gly Leu Glu Asp Ser Lys Arg Ser Lys Ser Leu Leu Pro Asp 
1345                1350                1355                1360
His Thr Ser Asp Asn Pro Phe Leu His Ser His Arg Asp Asp Gln Arg 
                1365                1370                1375    
Leu Val Ile Gly Arg Cys Pro Ser Asp Pro Tyr Lys His Ser Leu Pro 
            1380                1385                1390        
Ser Gln Ala Val Asn Asp Ser Tyr Leu Arg Ser Ser Leu Arg Ser Thr 
        1395                1400                1405            
Ala Ser Tyr Cys Ser Arg Asp Ser Arg Gly His Asn Asp Val Tyr Ile 
    1410                1415                1420                
Ser Glu His Val Met Pro Tyr Ala Ala Asn Lys Asn Asn Met Tyr Ser 
1425                1430                1435                1440
Thr Pro Arg Val Leu Asn Ser Cys Ser Asn Arg Arg Val Tyr Lys Lys 
                1445                1450                1455    
Met Pro Ser Ile Glu Ser Asp Val 
            1460                

<210> 45
<211> 137
<212> PRT
<213> Homo sapiens


<220> 
<223> GluN2A S1

<400> 45
Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe Val Ile 
1               5                   10                  15      
Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn Thr Val 
            20                  25                  30          
Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu Gly Met 
        35                  40                  45              
Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu Lys Lys 
    50                  55                  60                  
Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val Thr Asn 
65                  70                  75                  80  
Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met Ile Gly 
                85                  90                  95      
Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu Thr Ile 
            100                 105                 110         
Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe Val Glu 
        115                 120                 125             
Thr Gly Ile Ser Val Met Val Ser Arg 
    130                 135         

<210> 46
<211> 142
<212> PRT
<213> Homo sapiens


<220> 
<223> GluN2A S2

<400> 46
Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg Pro His Asp Tyr 
1               5                   10                  15      
Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly Ser Thr Glu Arg 
            20                  25                  30          
Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr Met Thr Lys Phe 
        35                  40                  45              
Asn Gln Lys Gly Val Glu Asp Ala Leu Val Ser Leu Lys Thr Gly Lys 
    50                  55                  60                  
Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn Tyr Lys Ala Gly 
65                  70                  75                  80  
Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser Gly Tyr Ile Phe 
                85                  90                  95      
Ala Thr Thr Gly Tyr Gly Ile Ala Leu Gln Lys Gly Ser Pro Trp Lys 
            100                 105                 110         
Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly Asp Gly Glu Met 
        115                 120                 125             
Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Cys His Asn 
    130                 135                 140         

<210> 47
<211> 683
<212> PRT
<213> Artificial Sequence


<220> 
<223> GluN2A ecd incl. signal sequence and GT-linker between S1 and S2

<400> 47
Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu 
1               5                   10                  15      
Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro 
            20                  25                  30          
Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu 
        35                  40                  45              
Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro 
    50                  55                  60                  
Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys 
65                  70                  75                  80  
Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His 
                85                  90                  95      
Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met 
            100                 105                 110         
Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His 
        115                 120                 125             
Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe 
    130                 135                 140                 
Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys 
145                 150                 155                 160 
Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile 
                165                 170                 175     
Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp 
            180                 185                 190         
Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr 
        195                 200                 205             
Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser 
    210                 215                 220                 
Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu 
225                 230                 235                 240 
Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile 
                245                 250                 255     
Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe 
            260                 265                 270         
Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu 
        275                 280                 285             
Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser 
    290                 295                 300                 
Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys 
305                 310                 315                 320 
Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro 
                325                 330                 335     
Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu 
            340                 345                 350         
Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys 
        355                 360                 365             
Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser 
    370                 375                 380                 
Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu 
385                 390                 395                 400 
Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     
Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn 
            420                 425                 430         
Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu 
        435                 440                 445             
Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu 
    450                 455                 460                 
Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val 
465                 470                 475                 480 
Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met 
                485                 490                 495     
Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu 
            500                 505                 510         
Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe 
        515                 520                 525             
Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Gly Thr Gln Val Thr 
    530                 535                 540                 
Gly Leu Ser Asp Lys Lys Phe Gln Arg Pro His Asp Tyr Ser Pro Pro 
545                 550                 555                 560 
Phe Arg Phe Gly Thr Val Pro Asn Gly Ser Thr Glu Arg Asn Ile Arg 
                565                 570                 575     
Asn Asn Tyr Pro Tyr Met His Gln Tyr Met Thr Lys Phe Asn Gln Lys 
            580                 585                 590         
Gly Val Glu Asp Ala Leu Val Ser Leu Lys Thr Gly Lys Leu Asp Ala 
        595                 600                 605             
Phe Ile Tyr Asp Ala Ala Val Leu Asn Tyr Lys Ala Gly Arg Asp Glu 
    610                 615                 620                 
Gly Cys Lys Leu Val Thr Ile Gly Ser Gly Tyr Ile Phe Ala Thr Thr 
625                 630                 635                 640 
Gly Tyr Gly Ile Ala Leu Gln Lys Gly Ser Pro Trp Lys Arg Gln Ile 
                645                 650                 655     
Asp Leu Ala Leu Leu Gln Phe Val Gly Asp Gly Glu Met Glu Glu Leu 
            660                 665                 670         
Glu Thr Leu Trp Leu Thr Gly Ile Cys His Asn 
        675                 680             

<210> 48
<211> 1484
<212> PRT
<213> Homo sapiens


<220> 
<223> Human GluN2B NM_000834

<400> 48
Met Lys Pro Arg Ala Glu Cys Cys Ser Pro Lys Phe Trp Leu Val Leu 
1               5                   10                  15      
Ala Val Leu Ala Val Ser Gly Ser Arg Ala Arg Ser Gln Lys Ser Pro 
            20                  25                  30          
Pro Ser Ile Gly Ile Ala Val Ile Leu Val Gly Thr Ser Asp Glu Val 
        35                  40                  45              
Ala Ile Lys Asp Ala His Glu Lys Asp Asp Phe His His Leu Ser Val 
    50                  55                  60                  
Val Pro Arg Val Glu Leu Val Ala Met Asn Glu Thr Asp Pro Lys Ser 
65                  70                  75                  80  
Ile Ile Thr Arg Ile Cys Asp Leu Met Ser Asp Arg Lys Ile Gln Gly 
                85                  90                  95      
Val Val Phe Ala Asp Asp Thr Asp Gln Glu Ala Ile Ala Gln Ile Leu 
            100                 105                 110         
Asp Phe Ile Ser Ala Gln Thr Leu Thr Pro Ile Leu Gly Ile His Gly 
        115                 120                 125             
Gly Ser Ser Met Ile Met Ala Asp Lys Asp Glu Ser Ser Met Phe Phe 
    130                 135                 140                 
Gln Phe Gly Pro Ser Ile Glu Gln Gln Ala Ser Val Met Leu Asn Ile 
145                 150                 155                 160 
Met Glu Glu Tyr Asp Trp Tyr Ile Phe Ser Ile Val Thr Thr Tyr Phe 
                165                 170                 175     
Pro Gly Tyr Gln Asp Phe Val Asn Lys Ile Arg Ser Thr Ile Glu Asn 
            180                 185                 190         
Ser Phe Val Gly Trp Glu Leu Glu Glu Val Leu Leu Leu Asp Met Ser 
        195                 200                 205             
Leu Asp Asp Gly Asp Ser Lys Ile Gln Asn Gln Leu Lys Lys Leu Gln 
    210                 215                 220                 
Ser Pro Ile Ile Leu Leu Tyr Cys Thr Lys Glu Glu Ala Thr Tyr Ile 
225                 230                 235                 240 
Phe Glu Val Ala Asn Ser Val Gly Leu Thr Gly Tyr Gly Tyr Thr Trp 
                245                 250                 255     
Ile Val Pro Ser Leu Val Ala Gly Asp Thr Asp Thr Val Pro Ala Glu 
            260                 265                 270         
Phe Pro Thr Gly Leu Ile Ser Val Ser Tyr Asp Glu Trp Asp Tyr Gly 
        275                 280                 285             
Leu Pro Ala Arg Val Arg Asp Gly Ile Ala Ile Ile Thr Thr Ala Ala 
    290                 295                 300                 
Ser Asp Met Leu Ser Glu His Ser Phe Ile Pro Glu Pro Lys Ser Ser 
305                 310                 315                 320 
Cys Tyr Asn Thr His Glu Lys Arg Ile Tyr Gln Ser Asn Met Leu Asn 
                325                 330                 335     
Arg Tyr Leu Ile Asn Val Thr Phe Glu Gly Arg Asn Leu Ser Phe Ser 
            340                 345                 350         
Glu Asp Gly Tyr Gln Met His Pro Lys Leu Val Ile Ile Leu Leu Asn 
        355                 360                 365             
Lys Glu Arg Lys Trp Glu Arg Val Gly Lys Trp Lys Asp Lys Ser Leu 
    370                 375                 380                 
Gln Met Lys Tyr Tyr Val Trp Pro Arg Met Cys Pro Glu Thr Glu Glu 
385                 390                 395                 400 
Gln Glu Asp Asp His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     
Val Ile Val Glu Ser Val Asp Pro Leu Ser Gly Thr Cys Met Arg Asn 
            420                 425                 430         
Thr Val Pro Cys Gln Lys Arg Ile Val Thr Glu Asn Lys Thr Asp Glu 
        435                 440                 445             
Glu Pro Gly Tyr Ile Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile 
    450                 455                 460                 
Leu Lys Lys Ile Ser Lys Ser Val Lys Phe Thr Tyr Asp Leu Tyr Leu 
465                 470                 475                 480 
Val Thr Asn Gly Lys His Gly Lys Lys Ile Asn Gly Thr Trp Asn Gly 
                485                 490                 495     
Met Ile Gly Glu Val Val Met Lys Arg Ala Tyr Met Ala Val Gly Ser 
            500                 505                 510         
Leu Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro 
        515                 520                 525             
Phe Ile Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr 
    530                 535                 540                 
Val Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Asp Val Trp Val 
545                 550                 555                 560 
Met Met Phe Val Met Leu Leu Ile Val Ser Ala Val Ala Val Phe Val 
                565                 570                 575     
Phe Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Cys Leu Ala Asp Gly 
            580                 585                 590         
Arg Glu Pro Gly Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu 
        595                 600                 605             
Leu Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys 
    610                 615                 620                 
Gly Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val 
625                 630                 635                 640 
Ile Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln 
                645                 650                 655     
Glu Glu Tyr Val Asp Gln Val Ser Gly Leu Ser Asp Lys Lys Phe Gln 
            660                 665                 670         
Arg Pro Asn Asp Phe Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn 
        675                 680                 685             
Gly Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Ala Glu Met His Ala 
    690                 695                 700                 
Tyr Met Gly Lys Phe Asn Gln Arg Gly Val Asp Asp Ala Leu Leu Ser 
705                 710                 715                 720 
Leu Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu 
                725                 730                 735     
Asn Tyr Met Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly 
            740                 745                 750         
Ser Gly Lys Val Phe Ala Ser Thr Gly Tyr Gly Ile Ala Ile Gln Lys 
        755                 760                 765             
Asp Ser Gly Trp Lys Arg Gln Val Asp Leu Ala Ile Leu Gln Leu Phe 
    770                 775                 780                 
Gly Asp Gly Glu Met Glu Glu Leu Glu Ala Leu Trp Leu Thr Gly Ile 
785                 790                 795                 800 
Cys His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp 
                805                 810                 815     
Asn Met Ala Gly Val Phe Tyr Met Leu Gly Ala Ala Met Ala Leu Ser 
            820                 825                 830         
Leu Ile Thr Phe Ile Cys Glu His Leu Phe Tyr Trp Gln Phe Arg His 
        835                 840                 845             
Cys Phe Met Gly Val Cys Ser Gly Lys Pro Gly Met Val Phe Ser Ile 
    850                 855                 860                 
Ser Arg Gly Ile Tyr Ser Cys Ile His Gly Val Ala Ile Glu Glu Arg 
865                 870                 875                 880 
Gln Ser Val Met Asn Ser Pro Thr Ala Thr Met Asn Asn Thr His Ser 
                885                 890                 895     
Asn Ile Leu Arg Leu Leu Arg Thr Ala Lys Asn Met Ala Asn Leu Ser 
            900                 905                 910         
Gly Val Asn Gly Ser Pro Gln Ser Ala Leu Asp Phe Ile Arg Arg Glu 
        915                 920                 925             
Ser Ser Val Tyr Asp Ile Ser Glu His Arg Arg Ser Phe Thr His Ser 
    930                 935                 940                 
Asp Cys Lys Ser Tyr Asn Asn Pro Pro Cys Glu Glu Asn Leu Phe Ser 
945                 950                 955                 960 
Asp Tyr Ile Ser Glu Val Glu Arg Thr Phe Gly Asn Leu Gln Leu Lys 
                965                 970                 975     
Asp Ser Asn Val Tyr Gln Asp His Tyr His His His His Arg Pro His 
            980                 985                 990         
Ser Ile Gly Ser Ala Ser Ser Ile Asp Gly Leu Tyr Asp Cys Asp Asn 
        995                 1000                1005            
Pro Pro Phe Thr Thr Gln Ser Arg Ser Ile Ser Lys Lys Pro Leu Asp 
    1010                1015                1020                
Ile Gly Leu Pro Ser Ser Lys His Ser Gln Leu Ser Asp Leu Tyr Gly 
1025                1030                1035                1040
Lys Phe Ser Phe Lys Ser Asp Arg Tyr Ser Gly His Asp Asp Leu Ile 
                1045                1050                1055    
Arg Ser Asp Val Ser Asp Ile Ser Thr His Thr Val Thr Tyr Gly Asn 
            1060                1065                1070        
Ile Glu Gly Asn Ala Ala Lys Arg Arg Lys Gln Gln Tyr Lys Asp Ser 
        1075                1080                1085            
Leu Lys Lys Arg Pro Ala Ser Ala Lys Ser Arg Arg Glu Phe Asp Glu 
    1090                1095                1100                
Ile Glu Leu Ala Tyr Arg Arg Arg Pro Pro Arg Ser Pro Asp His Lys 
1105                1110                1115                1120
Arg Tyr Phe Arg Asp Lys Glu Gly Leu Arg Asp Phe Tyr Leu Asp Gln 
                1125                1130                1135    
Phe Arg Thr Lys Glu Asn Ser Pro His Trp Glu His Val Asp Leu Thr 
            1140                1145                1150        
Asp Ile Tyr Lys Glu Arg Ser Asp Asp Phe Lys Arg Asp Ser Val Ser 
        1155                1160                1165            
Gly Gly Gly Pro Cys Thr Asn Arg Ser His Ile Lys His Gly Thr Gly 
    1170                1175                1180                
Asp Lys His Gly Val Val Ser Gly Val Pro Ala Pro Trp Glu Lys Asn 
1185                1190                1195                1200
Leu Thr Asn Val Glu Trp Glu Asp Arg Ser Gly Gly Asn Phe Cys Arg 
                1205                1210                1215    
Ser Cys Pro Ser Lys Leu His Asn Tyr Ser Thr Thr Val Thr Gly Gln 
            1220                1225                1230        
Asn Ser Gly Arg Gln Ala Cys Ile Arg Cys Glu Ala Cys Lys Lys Ala 
        1235                1240                1245            
Gly Asn Leu Tyr Asp Ile Ser Glu Asp Asn Ser Leu Gln Glu Leu Asp 
    1250                1255                1260                
Gln Pro Ala Ala Pro Val Ala Val Thr Ser Asn Ala Ser Thr Thr Lys 
1265                1270                1275                1280
Tyr Pro Gln Ser Pro Thr Asn Ser Lys Ala Gln Lys Lys Asn Arg Asn 
                1285                1290                1295    
Lys Leu Arg Arg Gln His Ser Tyr Asp Thr Phe Val Asp Leu Gln Lys 
            1300                1305                1310        
Glu Glu Ala Ala Leu Ala Pro Arg Ser Val Ser Leu Lys Asp Lys Gly 
        1315                1320                1325            
Arg Phe Met Asp Gly Ser Pro Tyr Ala His Met Phe Glu Met Ser Ala 
    1330                1335                1340                
Gly Glu Ser Thr Phe Ala Asn Asn Lys Ser Ser Val Pro Thr Ala Gly 
1345                1350                1355                1360
His His His His Asn Asn Pro Gly Gly Gly Tyr Met Leu Ser Lys Ser 
                1365                1370                1375    
Leu Tyr Pro Asp Arg Val Thr Gln Asn Pro Phe Ile Pro Thr Phe Gly 
            1380                1385                1390        
Asp Asp Gln Cys Leu Leu His Gly Ser Lys Ser Tyr Phe Phe Arg Gln 
        1395                1400                1405            
Pro Thr Val Ala Gly Ala Ser Lys Ala Arg Pro Asp Phe Arg Ala Leu 
    1410                1415                1420                
Val Thr Asn Lys Pro Val Val Ser Ala Leu His Gly Ala Val Pro Ala 
1425                1430                1435                1440
Arg Phe Gln Lys Asp Ile Cys Ile Gly Asn Gln Ser Asn Pro Cys Val 
                1445                1450                1455    
Pro Asn Asn Lys Asn Pro Arg Ala Phe Asn Gly Ser Ser Asn Gly His 
            1460                1465                1470        
Val Tyr Glu Lys Leu Ser Ser Ile Glu Ser Asp Val 
        1475                1480                

<210> 49
<211> 684
<212> PRT
<213> Artificial Sequence


<220> 
<223> GluN2B ecd incl. signal sequence and GT-linker between S1 and S2

<400> 49
Met Lys Pro Arg Ala Glu Cys Cys Ser Pro Lys Phe Trp Leu Val Leu 
1               5                   10                  15      
Ala Val Leu Ala Val Ser Gly Ser Arg Ala Arg Ser Gln Lys Ser Pro 
            20                  25                  30          
Pro Ser Ile Gly Ile Ala Val Ile Leu Val Gly Thr Ser Asp Glu Val 
        35                  40                  45              
Ala Ile Lys Asp Ala His Glu Lys Asp Asp Phe His His Leu Ser Val 
    50                  55                  60                  
Val Pro Arg Val Glu Leu Val Ala Met Asn Glu Thr Asp Pro Lys Ser 
65                  70                  75                  80  
Ile Ile Thr Arg Ile Cys Asp Leu Met Ser Asp Arg Lys Ile Gln Gly 
                85                  90                  95      
Val Val Phe Ala Asp Asp Thr Asp Gln Glu Ala Ile Ala Gln Ile Leu 
            100                 105                 110         
Asp Phe Ile Ser Ala Gln Thr Leu Thr Pro Ile Leu Gly Ile His Gly 
        115                 120                 125             
Gly Ser Ser Met Ile Met Ala Asp Lys Asp Glu Ser Ser Met Phe Phe 
    130                 135                 140                 
Gln Phe Gly Pro Ser Ile Glu Gln Gln Ala Ser Val Met Leu Asn Ile 
145                 150                 155                 160 
Met Glu Glu Tyr Asp Trp Tyr Ile Phe Ser Ile Val Thr Thr Tyr Phe 
                165                 170                 175     
Pro Gly Tyr Gln Asp Phe Val Asn Lys Ile Arg Ser Thr Ile Glu Asn 
            180                 185                 190         
Ser Phe Val Gly Trp Glu Leu Glu Glu Val Leu Leu Leu Asp Met Ser 
        195                 200                 205             
Leu Asp Asp Gly Asp Ser Lys Ile Gln Asn Gln Leu Lys Lys Leu Gln 
    210                 215                 220                 
Ser Pro Ile Ile Leu Leu Tyr Cys Thr Lys Glu Glu Ala Thr Tyr Ile 
225                 230                 235                 240 
Phe Glu Val Ala Asn Ser Val Gly Leu Thr Gly Tyr Gly Tyr Thr Trp 
                245                 250                 255     
Ile Val Pro Ser Leu Val Ala Gly Asp Thr Asp Thr Val Pro Ala Glu 
            260                 265                 270         
Phe Pro Thr Gly Leu Ile Ser Val Ser Tyr Asp Glu Trp Asp Tyr Gly 
        275                 280                 285             
Leu Pro Ala Arg Val Arg Asp Gly Ile Ala Ile Ile Thr Thr Ala Ala 
    290                 295                 300                 
Ser Asp Met Leu Ser Glu His Ser Phe Ile Pro Glu Pro Lys Ser Ser 
305                 310                 315                 320 
Cys Tyr Asn Thr His Glu Lys Arg Ile Tyr Gln Ser Asn Met Leu Asn 
                325                 330                 335     
Arg Tyr Leu Ile Asn Val Thr Phe Glu Gly Arg Asn Leu Ser Phe Ser 
            340                 345                 350         
Glu Asp Gly Tyr Gln Met His Pro Lys Leu Val Ile Ile Leu Leu Asn 
        355                 360                 365             
Lys Glu Arg Lys Trp Glu Arg Val Gly Lys Trp Lys Asp Lys Ser Leu 
    370                 375                 380                 
Gln Met Lys Tyr Tyr Val Trp Pro Arg Met Cys Pro Glu Thr Glu Glu 
385                 390                 395                 400 
Gln Glu Asp Asp His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     
Val Ile Val Glu Ser Val Asp Pro Leu Ser Gly Thr Cys Met Arg Asn 
            420                 425                 430         
Thr Val Pro Cys Gln Lys Arg Ile Val Thr Glu Asn Lys Thr Asp Glu 
        435                 440                 445             
Glu Pro Gly Tyr Ile Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile 
    450                 455                 460                 
Leu Lys Lys Ile Ser Lys Ser Val Lys Phe Thr Tyr Asp Leu Tyr Leu 
465                 470                 475                 480 
Val Thr Asn Gly Lys His Gly Lys Lys Ile Asn Gly Thr Trp Asn Gly 
                485                 490                 495     
Met Ile Gly Glu Val Val Met Lys Arg Ala Tyr Met Ala Val Gly Ser 
            500                 505                 510         
Leu Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro 
        515                 520                 525             
Phe Ile Glu Thr Gly Ile Ser Val Met Val Ser Arg Gly Thr Gln Val 
    530                 535                 540                 
Ser Gly Leu Ser Asp Lys Lys Phe Gln Arg Pro Asn Asp Phe Ser Pro 
545                 550                 555                 560 
Pro Phe Arg Phe Gly Thr Val Pro Asn Gly Ser Thr Glu Arg Asn Ile 
                565                 570                 575     
Arg Asn Asn Tyr Ala Glu Met His Ala Tyr Met Gly Lys Phe Asn Gln 
            580                 585                 590         
Arg Gly Val Asp Asp Ala Leu Leu Ser Leu Lys Thr Gly Lys Leu Asp 
        595                 600                 605             
Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn Tyr Met Ala Gly Arg Asp 
    610                 615                 620                 
Glu Gly Cys Lys Leu Val Thr Ile Gly Ser Gly Lys Val Phe Ala Ser 
625                 630                 635                 640 
Thr Gly Tyr Gly Ile Ala Ile Gln Lys Asp Ser Gly Trp Lys Arg Gln 
                645                 650                 655     
Val Asp Leu Ala Ile Leu Gln Leu Phe Gly Asp Gly Glu Met Glu Glu 
            660                 665                 670         
Leu Glu Ala Leu Trp Leu Thr Gly Ile Cys His Asn 
        675                 680                 

<210> 50
<211> 1896
<212> DNA
<213> Artificial Sequence


<220> 
<223> DNA sequence of fusion protein #1 N1-ATD-Fc

<400> 50
atgagcacca tgcgcctgct gacgctcgcc ctgctgttct cctgctccgt cgcccgtgcc      60

gcgtgcgacc ccaagatcgt caacattggc gcggtgctga gcacgcggaa gcacgagcag     120

atgttccgcg aggccgtgaa ccaggccaac aagcggcacg gctcctggaa gattcagctc     180

aatgccacct ccgtcacgca caagcccaac gccatccaga tggctctgtc ggtgtgcgag     240

gacctcatct ccagccaggt ctacgccatc ctagttagcc atccacctac ccccaacgac     300

cacttcactc ccacccctgt ctcctacaca gccggcttct accgcatacc cgtgctgggg     360

ctgaccaccc gcatgtccat ctactcggac aagagcatcc acctgagctt cctgcgcacc     420

gtgccgccct actcccacca gtccagcgtg tggtttgaga tgatgcgtgt ctacagctgg     480

aaccacatca tcctgctggt cagcgacgac cacgagggcc gggcggctca gaaacgcctg     540

gagacgctgc tggaggagcg tgagtccaag gcagagaagg tgctgcagtt tgacccaggg     600

accaagaacg tgacggccct gctgatggag gcgaaagagc tggaggcccg ggtcatcatc     660

ctttctgcca gcgaggacga tgctgccact gtataccgcg cagccgcgat gctgaacatg     720

acgggctccg ggtacgtgtg gctggtcggc gagcgcgaga tctcggggaa cgccctgcgc     780

tacgccccgg acggcatcct cgggctgcag ctcatcaacg gcaagaacga gtcggcccac     840

atcagcgacg ccgtaggcgt ggtggcccag gccgtgcacg agctcctcga gaaggagaac     900

atcaccgacc cgccgcgggg ctgcgtgggc aacaccaaca tctggaagac cgggccgctc     960

ttcaagagag tgctgatgtc ttccaagtat gcggatgggg tgactggtcg cgtggagttc    1020

aatgaggatg gggaccggaa gttcgccaac tacagcatca tgaacctgca gaaccgcaag    1080

ctggtgcaag tgggcatcta caatggcacc cacgtcatcc ctaatgacag gaagatcatc    1140

tggccaggcg gagagacaga gaagcctcga gggtaccaga tgtccaccag actgaagatt    1200

gggtcgagca ccatggttag atctagcaag cccacgtgcc caccccctga actcctgggg    1260

ggaccgtctg tcttcatctt ccccccaaaa cccaaggaca ccctcatgat ctcacgcacc    1320

cccgaggtca catgcgtggt ggtggacgtg agccaggatg accccgaggt gcagttcaca    1380

tggtacataa acaacgagca ggtgcgcacc gcccggccgc cgctacggga gcagcagttc    1440

aacagcacga tccgcgtggt cagcaccctc cccatcgcgc accaggactg gctgaggggc    1500

aaggagttca agtgcaaagt ccacaacaag gcactcccgg cccccatcga gaaaaccatc    1560

tccaaagcca gagggcagcc cctggagccg aaggtctaca ccatgggccc tccccgggag    1620

gagctgagca gcaggtcggt cagcctgacc tgcatgatca acggcttcta cccttccgac    1680

atctcggtgg agtgggagaa gaacgggaag gcagaggaca actacaagac cacgccggcc    1740

gtgctggaca gcgacggctc ctacttcctc tacagcaagc tctcagtgcc cacgagtgag    1800

tggcagcggg gcgacgtctt cacctgctcc gtgatgcacg aggccttgca caaccactac    1860

acgcagaagt ccatctcccg ctctccgggt aaatga                              1896


<210> 51
<211> 1200
<212> DNA
<213> Homo sapiens


<220> 
<223> Amino terminal domain (ATD) of GluN1 including the signal
      sequence

<400> 51
atgagcacca tgcgcctgct gacgctcgcc ctgctgttct cctgctccgt cgcccgtgcc      60

gcgtgcgacc ccaagatcgt caacattggc gcggtgctga gcacgcggaa gcacgagcag     120

atgttccgcg aggccgtgaa ccaggccaac aagcggcacg gctcctggaa gattcagctc     180

aatgccacct ccgtcacgca caagcccaac gccatccaga tggctctgtc ggtgtgcgag     240

gacctcatct ccagccaggt ctacgccatc ctagttagcc atccacctac ccccaacgac     300

cacttcactc ccacccctgt ctcctacaca gccggcttct accgcatacc cgtgctgggg     360

ctgaccaccc gcatgtccat ctactcggac aagagcatcc acctgagctt cctgcgcacc     420

gtgccgccct actcccacca gtccagcgtg tggtttgaga tgatgcgtgt ctacagctgg     480

aaccacatca tcctgctggt cagcgacgac cacgagggcc gggcggctca gaaacgcctg     540

gagacgctgc tggaggagcg tgagtccaag gcagagaagg tgctgcagtt tgacccaggg     600

accaagaacg tgacggccct gctgatggag gcgaaagagc tggaggcccg ggtcatcatc     660

ctttctgcca gcgaggacga tgctgccact gtataccgcg cagccgcgat gctgaacatg     720

acgggctccg ggtacgtgtg gctggtcggc gagcgcgaga tctcggggaa cgccctgcgc     780

tacgccccgg acggcatcct cgggctgcag ctcatcaacg gcaagaacga gtcggcccac     840

atcagcgacg ccgtaggcgt ggtggcccag gccgtgcacg agctcctcga gaaggagaac     900

atcaccgacc cgccgcgggg ctgcgtgggc aacaccaaca tctggaagac cgggccgctc     960

ttcaagagag tgctgatgtc ttccaagtat gcggatgggg tgactggtcg cgtggagttc    1020

aatgaggatg gggaccggaa gttcgccaac tacagcatca tgaacctgca gaaccgcaag    1080

ctggtgcaag tgggcatcta caatggcacc cacgtcatcc ctaatgacag gaagatcatc    1140

tggccaggcg gagagacaga gaagcctcga gggtaccaga tgtccaccag actgaagatt    1200


<210> 52
<211> 24
<212> DNA
<213> Homo sapiens


<220> 
<223> Linker between NMDAR domain and rabbit Fc to be used in fusion
      proteins of NMDAR protein constructs of invention

<400> 52
gggtcgagca ccatggttag atct                                           24


<210> 53
<211> 672
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rabbit Fc from Vector pFuse-rIgG-Fc1

<400> 53
agcaagccca cgtgcccacc ccctgaactc ctggggggac cgtctgtctt catcttcccc      60

ccaaaaccca aggacaccct catgatctca cgcacccccg aggtcacatg cgtggtggtg     120

gacgtgagcc aggatgaccc cgaggtgcag ttcacatggt acataaacaa cgagcaggtg     180

cgcaccgccc ggccgccgct acgggagcag cagttcaaca gcacgatccg cgtggtcagc     240

accctcccca tcgcgcacca ggactggctg aggggcaagg agttcaagtg caaagtccac     300

aacaaggcac tcccggcccc catcgagaaa accatctcca aagccagagg gcagcccctg     360

gagccgaagg tctacaccat gggccctccc cgggaggagc tgagcagcag gtcggtcagc     420

ctgacctgca tgatcaacgg cttctaccct tccgacatct cggtggagtg ggagaagaac     480

gggaaggcag aggacaacta caagaccacg ccggccgtgc tggacagcga cggctcctac     540

ttcctctaca gcaagctctc agtgcccacg agtgagtggc agcggggcga cgtcttcacc     600

tgctccgtga tgcacgaggc cttgcacaac cactacacgc agaagtccat ctcccgctct     660

ccgggtaaat ga                                                         672


<210> 54
<211> 1128
<212> DNA
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN1 in NM_007327

<400> 54
acgctcgccc tgctgttctc ctgctccgtc gcccgtgccg cgtgcgaccc caagatcgtc      60

aacattggcg cggtgctgag cacgcggaag cacgagcaga tgttccgcga ggccgtgaac     120

caggccaaca agcggcacgg ctcctggaag attcagctca atgccacctc cgtcacgcac     180

aagcccaacg ccatccagat ggctctgtcg gtgtgcgagg acctcatctc cagccaggtc     240

tacgccatcc tagttagcca tccacctacc cccaacgacc acttcactcc cacccctgtc     300

tcctacacag ccggcttcta ccgcataccc gtgctggggc tgaccacccg catgtccatc     360

tactcggaca agagcatcca cctgagcttc ctgcgcaccg tgccgcccta ctcccaccag     420

tccagcgtgt ggtttgagat gatgcgtgtc tacagctgga accacatcat cctgctggtc     480

agcgacgacc acgagggccg ggcggctcag aaacgcctgg agacgctgct ggaggagcgt     540

gagtccaagg cagagaaggt gctgcagttt gacccaggga ccaagaacgt gacggccctg     600

ctgatggagg cgaaagagct ggaggcccgg gtcatcatcc tttctgccag cgaggacgat     660

gctgccactg tataccgcgc agccgcgatg ctgaacatga cgggctccgg gtacgtgtgg     720

ctggtcggcg agcgcgagat ctcggggaac gccctgcgct acgccccaga cggcatcctc     780

gggctgcagc tcatcaacgg caagaacgag tcggcccaca tcagcgacgc cgtgggcgtg     840

gtggcccagg ccgtgcacga gctcctcgag aaggagaaca tcaccgaccc gccgcggggc     900

tgcgtgggca acaccaacat ctggaagacc gggccgctct tcaagagagt gctgatgtct     960

tccaagtatg cggatggggt gactggtcgc gtggagttca atgaggatgg ggaccggaag    1020

ttcgccaact acagcatcat gaacctgcag aaccgcaagc tggtgcaagt gggcatctac    1080

aatggcaccc acgtcatccc taatgacagg aagatcatct ggccaggc                 1128


<210> 55
<211> 2748
<212> DNA
<213> Artificial Sequence


<220> 
<223> DNA seq of fusion protein #2 N1ecd-Fc

<400> 55
atgagcacca tgcgcctgct gacgctcgcc ctgctgttct cctgctccgt cgcccgtgcc      60

gcgtgcgacc ccaagatcgt caacattggc gcggtgctga gcacgcggaa gcacgagcag     120

atgttccgcg aggccgtgaa ccaggccaac aagcggcacg gctcctggaa gattcagctc     180

aatgccacct ccgtcacgca caagcccaac gccatccaga tggctctgtc ggtgtgcgag     240

gacctcatct ccagccaggt ctacgccatc ctagttagcc atccacctac ccccaacgac     300

cacttcactc ccacccctgt ctcctacaca gccggcttct accgcatacc cgtgctgggg     360

ctgaccaccc gcatgtccat ctactcggac aagagcatcc acctgagctt cctgcgcacc     420

gtgccgccct actcccacca gtccagcgtg tggtttgaga tgatgcgtgt ctacagctgg     480

aaccacatca tcctgctggt cagcgacgac cacgagggcc gggcggctca gaaacgcctg     540

gagacgctgc tggaggagcg tgagtccaag gcagagaagg tgctgcagtt tgacccaggg     600

accaagaacg tgacggccct gctgatggag gcgaaagagc tggaggcccg ggtcatcatc     660

ctttctgcca gcgaggacga tgctgccact gtataccgcg cagccgcgat gctgaacatg     720

acgggctccg ggtacgtgtg gctggtcggc gagcgcgaga tctcggggaa cgccctgcgc     780

tacgccccgg acggcatcct cgggctgcag ctcatcaacg gcaagaacga gtcggcccac     840

atcagcgacg ccgtaggcgt ggtggcccag gccgtgcacg agctcctcga gaaggagaac     900

atcaccgacc cgccgcgggg ctgcgtgggc aacaccaaca tctggaagac cgggccgctc     960

ttcaagagag tgctgatgtc ttccaagtat gcggatgggg tgactggtcg cgtggagttc    1020

aatgaggatg gggaccggaa gttcgccaac tacagcatca tgaacctgca gaaccgcaag    1080

ctggtgcaag tgggcatcta caatggcacc cacgtcatcc ctaatgacag gaagatcatc    1140

tggccaggcg gagagacaga gaagcctcga gggtaccaga tgtccaccag actgaagatt    1200

gtgacgatcc accaggagcc cttcgtgtac gtcaagccca cgctgagtga tgggacatgc    1260

aaggaggagt tcacagtcaa cggcgaccca gtcaagaagg tgatctgcac cgggcccaac    1320

gacacgtcgc cgggcagccc ccgccacacg gtgcctcagt gttgctacgg cttttgcatc    1380

gacctgctca tcaagctggc acggaccatg aacttcacct acgaggtgca cctggtggca    1440

gatggcaagt tcggcacaca ggagcgggtg aacaacagca acaagaagga gtggaatggg    1500

atgatgggcg agctgctcag cgggcaggca gacatgatcg tggcgccgct aaccataaac    1560

aacgagcgcg cgcagtacat cgagttttcc aagcccttca agtaccaggg cctgactatt    1620

ctggtcaaga agggcacccg catcacgggc atcaacgacc cccggctgag gaacccctcg    1680

gacaagttta tctacgccac ggtgaagcag agctccgtgg atatctactt ccggcgccag    1740

gtggagctga gcaccatgta ccggcatatg gagaagcaca actacgagag tgcggcggag    1800

gccatccagg ccgtgagaga caacaagctg catgccttca tctgggactc ggcggtgctg    1860

gagttcgagg cctcgcagaa gtgcgacctg gtgacgactg gagagctgtt tttccgctcg    1920

ggcttcggca taggcatgcg caaagacagc ccctggaagc agaacgtctc cctgtccatc    1980

ctcaagtccc acgagaatgg cttcatggaa gacctggaca agacgtgggt tcggtatcag    2040

gaatgtgact cggggtcgag caccatggtt agatctagca agcccacgtg cccaccccct    2100

gaactcctgg ggggaccgtc tgtcttcatc ttccccccaa aacccaagga caccctcatg    2160

atctcacgca cccccgaggt cacatgcgtg gtggtggacg tgagccagga tgaccccgag    2220

gtgcagttca catggtacat aaacaacgag caggtgcgca ccgcccggcc gccgctacgg    2280

gagcagcagt tcaacagcac gatccgcgtg gtcagcaccc tccccatcgc gcaccaggac    2340

tggctgaggg gcaaggagtt caagtgcaaa gtccacaaca aggcactccc ggcccccatc    2400

gagaaaacca tctccaaagc cagagggcag cccctggagc cgaaggtcta caccatgggc    2460

cctccccggg aggagctgag cagcaggtcg gtcagcctga cctgcatgat caacggcttc    2520

tacccttccg acatctcggt ggagtgggag aagaacggga aggcagagga caactacaag    2580

accacgccgg ccgtgctgga cagcgacggc tcctacttcc tctacagcaa gctctcagtg    2640

cccacgagtg agtggcagcg gggcgacgtc ttcacctgct ccgtgatgca cgaggccttg    2700

cacaaccact acacgcagaa gtccatctcc cgctctccgg gtaaatga                 2748


<210> 56
<211> 1200
<212> DNA
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN1 (including signal sequence)

<400> 56
atgagcacca tgcgcctgct gacgctcgcc ctgctgttct cctgctccgt cgcccgtgcc      60

gcgtgcgacc ccaagatcgt caacattggc gcggtgctga gcacgcggaa gcacgagcag     120

atgttccgcg aggccgtgaa ccaggccaac aagcggcacg gctcctggaa gattcagctc     180

aatgccacct ccgtcacgca caagcccaac gccatccaga tggctctgtc ggtgtgcgag     240

gacctcatct ccagccaggt ctacgccatc ctagttagcc atccacctac ccccaacgac     300

cacttcactc ccacccctgt ctcctacaca gccggcttct accgcatacc cgtgctgggg     360

ctgaccaccc gcatgtccat ctactcggac aagagcatcc acctgagctt cctgcgcacc     420

gtgccgccct actcccacca gtccagcgtg tggtttgaga tgatgcgtgt ctacagctgg     480

aaccacatca tcctgctggt cagcgacgac cacgagggcc gggcggctca gaaacgcctg     540

gagacgctgc tggaggagcg tgagtccaag gcagagaagg tgctgcagtt tgacccaggg     600

accaagaacg tgacggccct gctgatggag gcgaaagagc tggaggcccg ggtcatcatc     660

ctttctgcca gcgaggacga tgctgccact gtataccgcg cagccgcgat gctgaacatg     720

acgggctccg ggtacgtgtg gctggtcggc gagcgcgaga tctcggggaa cgccctgcgc     780

tacgccccgg acggcatcct cgggctgcag ctcatcaacg gcaagaacga gtcggcccac     840

atcagcgacg ccgtaggcgt ggtggcccag gccgtgcacg agctcctcga gaaggagaac     900

atcaccgacc cgccgcgggg ctgcgtgggc aacaccaaca tctggaagac cgggccgctc     960

ttcaagagag tgctgatgtc ttccaagtat gcggatgggg tgactggtcg cgtggagttc    1020

aatgaggatg gggaccggaa gttcgccaac tacagcatca tgaacctgca gaaccgcaag    1080

ctggtgcaag tgggcatcta caatggcacc cacgtcatcc ctaatgacag gaagatcatc    1140

tggccaggcg gagagacaga gaagcctcga gggtaccaga tgtccaccag actgaagatt    1200


<210> 57
<211> 450
<212> DNA
<213> Homo sapiens


<220> 
<223> Ligand-binding domain of GluN1 S1

<400> 57
tccaccagac tgaagattgt gacgatccac caggagccct tcgtgtacgt caagcccacg      60

ctgagtgatg ggacatgcaa ggaggagttc acagtcaacg gcgacccagt caagaaggtg     120

atctgcaccg ggcccaacga cacgtcgccg ggcagccccc gccacacggt gcctcagtgt     180

tgctacggct tttgcatcga cctgctcatc aagctggcac ggaccatgaa cttcacctac     240

gaggtgcacc tggtggcaga tggcaagttc ggcacacagg agcgggtgaa caacagcaac     300

aagaaggagt ggaatgggat gatgggcgag ctgctcagcg ggcaggcaga catgatcgtg     360

gcgccgctaa ccataaacaa cgagcgcgcg cagtacatcg agttttccaa gcccttcaag     420

taccagggcc tgactattct ggtcaagaag                                      450


<210> 58

<400> 58

000


<210> 59
<211> 414
<212> DNA
<213> Homo sapiens


<220> 
<223> Ligand-binding domain of GluN1 S2

<400> 59
cgcatcacgg gcatcaacga cccccggctg aggaacccct cggacaagtt tatctacgcc      60

acggtgaagc agagctccgt ggatatctac ttccggcgcc aggtggagct gagcaccatg     120

taccggcata tggagaagca caactacgag agtgcggcgg aggccatcca ggccgtgaga     180

gacaacaagc tgcatgcctt catctgggac tcggcggtgc tggagttcga ggcctcgcag     240

aagtgcgacc tggtgacgac tggagagctg tttttccgct cgggcttcgg cataggcatg     300

cgcaaagaca gcccctggaa gcagaacgtc tccctgtcca tcctcaagtc ccacgagaat     360

ggcttcatgg aagacctgga caagacgtgg gttcggtatc aggaatgtga ctcg           414


<210> 60
<211> 411
<212> DNA
<213> Homo sapiens


<220> 
<223> Ligand-binding domain of GluN1 S2 in NM_007327

<400> 60
cgcatcacgg gcatcaacga ccctcggctg aggaacccct cggacaagtt tatctacgcc      60

acggtgaagc agagctccgt ggatatctac ttccggcgcc aggtggagct gagcaccatg     120

taccggcata tggagaagca caactacgag agtgcggcgg aggccatcca ggccgtgaga     180

gacaacaagc tgcatgcctt catctgggac tcggcggtgc tggagttcga ggcctcgcag     240

aagtgcgacc tggtgacgac tggagagctg tttttccgct cgggcttcgg cataggcatg     300

cgcaaagaca gcccctggaa gcagaacgtc tccctgtcca tcctcaagtc ccacgagaat     360

ggcttcatgg aagacctgga caagacgtgg gttcggtatc aggaatgtga c              411


<210> 61
<211> 2748
<212> DNA
<213> Artificial Sequence


<220> 
<223> DNA seq of fusion protein #3 N2Becd-Fc

<400> 61
atgaagccca gagcggagtg ctgttctccc aagttctggt tggtgttggc cgtcctggcc      60

gtgtcaggca gcagagctcg ttctcagaag agccccccca gcattggcat tgctgtcatc     120

ctcgtgggca cttccgacga ggtggccatc aaggatgccc acgagaaaga tgatttccac     180

catctctccg tggtaccccg ggtggaactg gtagccatga atgagaccga cccaaagagc     240

atcatcaccc gcatctgtga tctcatgtct gaccggaaga tccagggggt ggtgtttgct     300

gatgacacag accaggaagc catcgcccag atcctcgatt tcatttcagc acagactctc     360

accccgatcc tgggcatcca cgggggctcc tctatgataa tggcagataa ggatgaatcc     420

tccatgttct tccagtttgg cccatcaatt gaacagcaag cttccgtaat gctcaacatc     480

atggaagaat atgactggta catcttttct atcgtcacca cctatttccc tggctaccag     540

gactttgtaa acaagatccg cagcaccatt gagaatagct ttgtgggctg ggagctagag     600

gaggtcctcc tactggacat gtccctggac gatggagatt ctaagatcca gaatcagctc     660

aagaaacttc aaagccccat cattcttctt tactgtacca aggaagaagc cacctacatc     720

tttgaagtgg ccaactcagt agggctgact ggctatggct acacgtggat cgtgcccagt     780

ctggtggcag gggatacaga cacagtgcct gcggagttcc ccactgggct catctctgta     840

tcatatgatg aatgggacta tggcctcccc gccagagtga gagatggaat tgccataatc     900

accactgctg cttctgacat gctgtctgag cacagcttca tccctgagcc caaaagcagt     960

tgttacaaca cccacgagaa gagaatctac cagtccaata tgctaaatag gtatctgatc    1020

aatgtcactt ttgaggggag gaatttgtcc ttcagtgaag atggctacca gatgcacccg    1080

aaactggtga taattcttct gaacaaggag aggaagtggg aaagggtggg gaagtggaaa    1140

gacaagtccc tgcagatgaa gtactatgtg tggccccgaa tgtgtccaga gactgaagag    1200

caggaggatg accatctgag cattgtgacc ctggaggagg caccatttgt cattgtggaa    1260

agtgtggacc ctctgagtgg aacctgcatg aggaacacag tcccctgcca aaaacgcata    1320

gtcactgaga ataaaacaga cgaggagccg ggttacatca aaaaatgctg caaggggttc    1380

tgtattgaca tccttaagaa aatttctaaa tctgtgaagt tcacctatga cctttacctg    1440

gttaccaatg gcaagcatgg gaagaaaatc aatggaacct ggaatggtat gattggagag    1500

gtggtcatga agagggccta catggcagtg ggctcactca ccatcaatga ggaacgatcg    1560

gaggtggtcg acttctctgt gcccttcata gagacaggca tcagtgtcat ggtgtcacgc    1620

ggcacccagg tttctggcct gagcgacaaa aagttccaga gacctaatga cttctcaccc    1680

cctttccgct ttgggaccgt gcccaacggc agcacagaga gaaatattcg caataactat    1740

gcagaaatgc atgcctacat gggaaagttc aaccagaggg gtgtagatga tgcattgctc    1800

tccctgaaaa cagggaaact ggatgccttc atctatgatg cagcagtgct gaactatatg    1860

gcaggcagag atgaaggctg caagctggtg accattggca gtgggaaggt ctttgcttcc    1920

actggctatg gcattgccat ccaaaaagat tctgggtgga agcgccaggt ggaccttgct    1980

atcctgcagc tctttggaga tggggagatg gaagaactgg aagctctctg gctcactggc    2040

atttgtcaca atggctcgag caccatggtt agatctagca agcccacgtg cccaccccct    2100

gaactcctgg ggggaccgtc tgtcttcatc ttccccccaa aacccaagga caccctcatg    2160

atctcacgca cccccgaggt cacatgcgtg gtggtggacg tgagccagga tgaccccgag    2220

gtgcagttca catggtacat aaacaacgag caggtgcgca ccgcccggcc gccgctacgg    2280

gagcagcagt tcaacagcac gatccgcgtg gtcagcaccc tccccatcgc gcaccaggac    2340

tggctgaggg gcaaggagtt caagtgcaaa gtccacaaca aggcactccc ggcccccatc    2400

gagaaaacca tctccaaagc cagagggcag cccctggagc cgaaggtcta caccatgggc    2460

cctccccggg aggagctgag cagcaggtcg gtcagcctga cctgcatgat caacggcttc    2520

tacccttccg acatctcggt ggagtgggag aagaacggga aggcagagga caactacaag    2580

accacgccgg ccgtgctgga cagcgacggc tcctacttcc tctacagcaa gctctcagtg    2640

cccacgagtg agtggcagcg gggcgacgtc ttcacctgct ccgtgatgca cgaggccttg    2700

cacaaccact acacgcagaa gtccatctcc cgctctccgg gtaaatga                 2748


<210> 62
<211> 1203
<212> DNA
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN2B (including signal sequence)

<400> 62
atgaagccca gagcggagtg ctgttctccc aagttctggt tggtgttggc cgtcctggcc      60

gtgtcaggca gcagagctcg ttctcagaag agccccccca gcattggcat tgctgtcatc     120

ctcgtgggca cttccgacga ggtggccatc aaggatgccc acgagaaaga tgatttccac     180

catctctccg tggtaccccg ggtggaactg gtagccatga atgagaccga cccaaagagc     240

atcatcaccc gcatctgtga tctcatgtct gaccggaaga tccagggggt ggtgtttgct     300

gatgacacag accaggaagc catcgcccag atcctcgatt tcatttcagc acagactctc     360

accccgatcc tgggcatcca cgggggctcc tctatgataa tggcagataa ggatgaatcc     420

tccatgttct tccagtttgg cccatcaatt gaacagcaag cttccgtaat gctcaacatc     480

atggaagaat atgactggta catcttttct atcgtcacca cctatttccc tggctaccag     540

gactttgtaa acaagatccg cagcaccatt gagaatagct ttgtgggctg ggagctagag     600

gaggtcctcc tactggacat gtccctggac gatggagatt ctaagatcca gaatcagctc     660

aagaaacttc aaagccccat cattcttctt tactgtacca aggaagaagc cacctacatc     720

tttgaagtgg ccaactcagt agggctgact ggctatggct acacgtggat cgtgcccagt     780

ctggtggcag gggatacaga cacagtgcct gcggagttcc ccactgggct catctctgta     840

tcatatgatg aatgggacta tggcctcccc gccagagtga gagatggaat tgccataatc     900

accactgctg cttctgacat gctgtctgag cacagcttca tccctgagcc caaaagcagt     960

tgttacaaca cccacgagaa gagaatctac cagtccaata tgctaaatag gtatctgatc    1020

aatgtcactt ttgaggggag gaatttgtcc ttcagtgaag atggctacca gatgcacccg    1080

aaactggtga taattcttct gaacaaggag aggaagtggg aaagggtggg gaagtggaaa    1140

gacaagtccc tgcagatgaa gtactatgtg tggccccgaa tgtgtccaga gactgaagag    1200

cag                                                                  1203


<210> 63
<211> 417
<212> DNA
<213> Homo sapiens


<220> 
<223> Ligand-binding domain of GluN2B S1

<400> 63
gaggatgacc atctgagcat tgtgaccctg gaggaggcac catttgtcat tgtggaaagt      60

gtggaccctc tgagtggaac ctgcatgagg aacacagtcc cctgccaaaa acgcatagtc     120

actgagaata aaacagacga ggagccgggt tacatcaaaa aatgctgcaa ggggttctgt     180

attgacatcc ttaagaaaat ttctaaatct gtgaagttca cctatgacct ttacctggtt     240

accaatggca agcatgggaa gaaaatcaat ggaacctgga atggtatgat tggagaggtg     300

gtcatgaaga gggcctacat ggcagtgggc tcactcacca tcaatgagga acgatcggag     360

gtggtcgact tctctgtgcc cttcatagag acaggcatca gtgtcatggt gtcacgc        417


<210> 64
<211> 425
<212> DNA
<213> Homo sapiens


<220> 
<223> Ligand-binding domain of GluN2B S2

<400> 64
aggtttctgg cctgagcgac aaaaagttcc agagacctaa tgacttctca ccccctttcc      60

gctttgggac cgtgcccaac ggcagcacag agagaaatat tcgcaataac tatgcagaaa     120

tgcatgccta catgggaaag ttcaaccaga ggggtgtaga tgatgcattg ctctccctga     180

aaacagggaa actggatgcc ttcatctatg atgcagcagt gctgaactat atggcaggca     240

gagatgaagg ctgcaagctg gtgaccattg gcagtgggaa ggtctttgct tccactggct     300

atggcattgc catccaaaaa gattctgggt ggaagcgcca ggtggacctt gctatcctgc     360

agctctttgg agatggggag atggaagaac tggaagctct ctggctcact ggcatttgtc     420

acaat                                                                 425


<210> 65
<211> 1083
<212> DNA
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN2B in NM_000834

<400> 65
cccagcattg gcattgctgt catcctcgtg ggcacttccg acgaggtggc catcaaggat      60

gcccacgaga aagatgattt ccaccatctc tccgtggtac cccgggtgga actggtagcc     120

atgaatgaga ccgacccaaa gagcatcatc acccgcatct gtgatctcat gtctgaccgg     180

aagatccagg gggtggtgtt tgctgatgac acagaccagg aagccatcgc ccagatcctc     240

gatttcattt cagcacagac tctcaccccc atcctgggca tccacggggg ctcctctatg     300

ataatggcag ataaggatga atcctccatg ttcttccagt ttggcccatc aattgaacag     360

caagcttccg taatgctcaa catcatggaa gaatatgact ggtacatctt ttctatcgtc     420

accacctatt tccctggcta ccaggacttt gtaaacaaga tccgcagcac cattgagaat     480

agctttgtgg gctgggagct agaggaggtc ctcctactgg acatgtccct ggacgatgga     540

gattctaaga tccagaatca gctcaagaaa cttcaaagcc ccatcattct tctttactgt     600

accaaggaag aagccaccta catctttgaa gtggccaact cagtagggct gactggctat     660

ggctacacgt ggatcgtgcc cagtctggtg gcaggggata cagacacagt gcctgcggag     720

ttccccactg ggctcatctc tgtatcatat gatgaatggg actatggcct ccccgccaga     780

gtgagagatg gaattgccat aatcaccact gctgcttctg acatgctgtc tgagcacagc     840

ttcatccctg agcccaaaag cagttgttac aacacccacg agaagagaat ctaccagtcc     900

aatatgctaa ataggtatct gatcaatgtc acttttgagg ggaggaattt gtccttcagt     960

gaagatggct accagatgca cccgaaactg gtgataattc ttctgaacaa ggagaggaag    1020

tgggaaaggg tggggaagtg gaaagacaag tccctgcaga tgaagtacta tgtgtggccc    1080

cga                                                                  1083


<210> 66
<211> 414
<212> DNA
<213> Homo sapiens


<220> 
<223> Ligand-binding domain of GluN2B S1 in NM_000834

<400> 66
gatgaccatc tgagcattgt gaccctggag gaggcaccat ttgtcattgt ggaaagtgtg      60

gaccctctga gtggaacctg catgaggaac acagtcccct gccaaaaacg catagtcact     120

gagaataaaa cagacgagga gccgggttac atcaaaaaat gctgcaaggg gttctgtatt     180

gacatcctta agaaaatttc taaatctgtg aagttcacct atgaccttta cctggttacc     240

aatggcaagc atgggaagaa aatcaatgga acctggaatg gtatgattgg agaggtggtc     300

atgaagaggg cctacatggc agtgggctca ctcaccatca atgaggaacg atcggaggtg     360

gtcgacttct ctgtgccctt catagagaca ggcatcagtg tcatggtgtc acgc           414


<210> 67
<211> 426
<212> DNA
<213> Homo sapiens


<220> 
<223> Ligand-binding domain of GluN2B S2 in NM_000834

<400> 67
caggtttctg gcctgagcga caaaaagttc cagagaccta atgacttctc accccctttc      60

cgctttggga ccgtgcccaa cggcagcaca gagagaaata ttcgcaataa ctatgcagaa     120

atgcatgcct acatgggaaa gttcaaccag aggggtgtag atgatgcatt gctctccctg     180

aaaacaggga aactggatgc cttcatctat gatgcagcag tgctgaacta tatggcaggc     240

agagatgaag gctgcaagct ggtgaccatt ggcagtggga aggtctttgc ttccactggc     300

tatggcattg ccatccaaaa agattctggg tggaagcgcc aggtggacct tgctatcctg     360

cagctctttg gagatgggga gatggaagaa ctggaagctc tctggctcac tggcatttgt     420

cacaat                                                                426


<210> 68
<211> 4785
<212> DNA
<213> Artificial Sequence


<220> 
<223> DNA seq of fusion protein #4 N1ecd-N2Becd-Fc

<400> 68
atgagcacca tgcgcctgct gacgctcgcc ctgctgttct cctgctccgt cgcccgtgcc       60

gcgtgcgacc ccaagatcgt caacattggc gcggtgctga gcacgcggaa gcacgagcag      120

atgttccgcg aggccgtgaa ccaggccaac aagcggcacg gctcctggaa gattcagctc      180

aatgccacct ccgtcacgca caagcccaac gccatccaga tggctctgtc ggtgtgcgag      240

gacctcatct ccagccaggt ctacgccatc ctagttagcc atccacctac ccccaacgac      300

cacttcactc ccacccctgt ctcctacaca gccggcttct accgcatacc cgtgctgggg      360

ctgaccaccc gcatgtccat ctactcggac aagagcatcc acctgagctt cctgcgcacc      420

gtgccgccct actcccacca gtccagcgtg tggtttgaga tgatgcgtgt ctacagctgg      480

aaccacatca tcctgctggt cagcgacgac cacgagggcc gggcggctca gaaacgcctg      540

gagacgctgc tggaggagcg tgagtccaag gcagagaagg tgctgcagtt tgacccaggg      600

accaagaacg tgacggccct gctgatggag gcgaaagagc tggaggcccg ggtcatcatc      660

ctttctgcca gcgaggacga tgctgccact gtataccgcg cagccgcgat gctgaacatg      720

acgggctccg ggtacgtgtg gctggtcggc gagcgcgaga tctcggggaa cgccctgcgc      780

tacgccccgg acggcatcct cgggctgcag ctcatcaacg gcaagaacga gtcggcccac      840

atcagcgacg ccgtaggcgt ggtggcccag gccgtgcacg agctcctcga gaaggagaac      900

atcaccgacc cgccgcgggg ctgcgtgggc aacaccaaca tctggaagac cgggccgctc      960

ttcaagagag tgctgatgtc ttccaagtat gcggatgggg tgactggtcg cgtggagttc     1020

aatgaggatg gggaccggaa gttcgccaac tacagcatca tgaacctgca gaaccgcaag     1080

ctggtgcaag tgggcatcta caatggcacc cacgtcatcc ctaatgacag gaagatcatc     1140

tggccaggcg gagagacaga gaagcctcga gggtaccaga tgtccaccag actgaagatt     1200

gtgacgatcc accaggagcc cttcgtgtac gtcaagccca cgctgagtga tgggacatgc     1260

aaggaggagt tcacagtcaa cggcgaccca gtcaagaagg tgatctgcac cgggcccaac     1320

gacacgtcgc cgggcagccc ccgccacacg gtgcctcagt gttgctacgg cttttgcatc     1380

gacctgctca tcaagctggc acggaccatg aacttcacct acgaggtgca cctggtggca     1440

gatggcaagt tcggcacaca ggagcgggtg aacaacagca acaagaagga gtggaatggg     1500

atgatgggcg agctgctcag cgggcaggca gacatgatcg tggcgccgct aaccataaac     1560

aacgagcgcg cgcagtacat cgagttttcc aagcccttca agtaccaggg cctgactatt     1620

ctggtcaaga agggcacccg catcacgggc atcaacgacc cccggctgag gaacccctcg     1680

gacaagttta tctacgccac ggtgaagcag agctccgtgg atatctactt ccggcgccag     1740

gtggagctga gcaccatgta ccggcatatg gagaagcaca actacgagag tgcggcggag     1800

gccatccagg ccgtgagaga caacaagctg catgccttca tctgggactc ggcggtgctg     1860

gagttcgagg cctcgcagaa gtgcgacctg gtgacgactg gagagctgtt tttccgctcg     1920

ggcttcggca taggcatgcg caaagacagc ccctggaagc agaacgtctc cctgtccatc     1980

ctcaagtccc acgagaatgg cttcatggaa gacctggaca agacgtgggt tcggtatcag     2040

gaatgtgact cggggtcgac tggtggagga gggtctggcg gaggtggttc cgggggcgga     2100

ggatctgggg ccgcttctag acagaagagc ccccccagca ttggcattgc tgtcatcctc     2160

gtgggcactt ccgacgaggt ggccatcaag gatgcccacg agaaagatga tttccaccat     2220

ctctccgtgg taccccgggt ggaactggta gccatgaatg agaccgaccc aaagagcatc     2280

atcacccgca tctgtgatct catgtctgac cggaagatcc agggggtggt gtttgctgat     2340

gacacagacc aggaagccat cgcccagatc ctcgatttca tttcagcaca gactctcacc     2400

ccgatcctgg gcatccacgg gggctcctct atgataatgg cagataagga tgaatcctcc     2460

atgttcttcc agtttggccc atcaattgaa cagcaagctt ccgtaatgct caacatcatg     2520

gaagaatatg actggtacat cttttctatc gtcaccacct atttccctgg ctaccaggac     2580

tttgtaaaca agatccgcag caccattgag aatagctttg tgggctggga gctagaggag     2640

gtcctcctac tggacatgtc cctggacgat ggagattcta agatccagaa tcagctcaag     2700

aaacttcaaa gccccatcat tcttctttac tgtaccaagg aagaagccac ctacatcttt     2760

gaagtggcca actcagtagg gctgactggc tatggctaca cgtggatcgt gcccagtctg     2820

gtggcagggg atacagacac agtgcctgcg gagttcccca ctgggctcat ctctgtatca     2880

tatgatgaat gggactatgg cctccccgcc agagtgagag atggaattgc cataatcacc     2940

actgctgctt ctgacatgct gtctgagcac agcttcatcc ctgagcccaa aagcagttgt     3000

tacaacaccc acgagaagag aatctaccag tccaatatgc taaataggta tctgatcaat     3060

gtcacttttg aggggaggaa tttgtccttc agtgaagatg gctaccagat gcacccgaaa     3120

ctggtgataa ttcttctgaa caaggagagg aagtgggaaa gggtggggaa gtggaaagac     3180

aagtccctgc agatgaagta ctatgtgtgg ccccgaatgt gtccagagac tgaagagcag     3240

gaggatgacc atctgagcat tgtgaccctg gaggaggcac catttgtcat tgtggaaagt     3300

gtggaccctc tgagtggaac ctgcatgagg aacacagtcc cctgccaaaa acgcatagtc     3360

actgagaata aaacagacga ggagccgggt tacatcaaaa aatgctgcaa ggggttctgt     3420

attgacatcc ttaagaaaat ttctaaatct gtgaagttca cctatgacct ttacctggtt     3480

accaatggca agcatgggaa gaaaatcaat ggaacctgga atggtatgat tggagaggtg     3540

gtcatgaaga gggcctacat ggcagtgggc tcactcacca tcaatgagga acgatcggag     3600

gtggtcgact tctctgtgcc cttcatagag acaggcatca gtgtcatggt gtcacgcggc     3660

acccaggttt ctggcctgag cgacaaaaag ttccagagac ctaatgactt ctcaccccct     3720

ttccgctttg ggaccgtgcc caacggcagc acagagagaa atattcgcaa taactatgca     3780

gaaatgcatg cctacatggg aaagttcaac cagaggggtg tagatgatgc attgctctcc     3840

ctgaaaacag ggaaactgga tgccttcatc tatgatgcag cagtgctgaa ctatatggca     3900

ggcagagatg aaggctgcaa gctggtgacc attggcagtg ggaaggtctt tgcttccact     3960

ggctatggca ttgccatcca aaaagattct gggtggaagc gccaggtgga ccttgctatc     4020

ctgcagctct ttggagatgg ggagatggaa gaactggaag ctctctggct cactggcatt     4080

tgtcacaatg gctcgagcac catggttaga tctagcaagc ccacgtgccc accccctgaa     4140

ctcctggggg gaccgtctgt cttcatcttc cccccaaaac ccaaggacac cctcatgatc     4200

tcacgcaccc ccgaggtcac atgcgtggtg gtggacgtga gccaggatga ccccgaggtg     4260

cagttcacat ggtacataaa caacgagcag gtgcgcaccg cccggccgcc gctacgggag     4320

cagcagttca acagcacgat ccgcgtggtc agcaccctcc ccatcgcgca ccaggactgg     4380

ctgaggggca aggagttcaa gtgcaaagtc cacaacaagg cactcccggc ccccatcgag     4440

aaaaccatct ccaaagccag agggcagccc ctggagccga aggtctacac catgggccct     4500

ccccgggagg agctgagcag caggtcggtc agcctgacct gcatgatcaa cggcttctac     4560

ccttccgaca tctcggtgga gtgggagaag aacgggaagg cagaggacaa ctacaagacc     4620

acgccggccg tgctggacag cgacggctcc tacttcctct acagcaagct ctcagtgccc     4680

acgagtgagt ggcagcgggg cgacgtcttc acctgctccg tgatgcacga ggccttgcac     4740

aaccactaca cgcagaagtc catctcccgc tctccgggta aatga                     4785


<210> 69
<211> 69
<212> DNA
<213> Artificial Sequence


<220> 
<223> Linker between a GluN1-domain and GluN2B-domain in a NMDAR
      construct of the invention

<400> 69
gggtcgactg gtggaggagg gtctggcgga ggtggttccg ggggcggagg atctggggcc     60

gcttctaga                                                             69


<210> 70
<211> 1119
<212> DNA
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN2B

<400> 70
cagaagagcc cccccagcat tggcattgct gtcatcctcg tgggcacttc cgacgaggtg      60

gccatcaagg atgcccacga gaaagatgat ttccaccatc tctccgtggt accccgggtg     120

gaactggtag ccatgaatga gaccgaccca aagagcatca tcacccgcat ctgtgatctc     180

atgtctgacc ggaagatcca gggggtggtg tttgctgatg acacagacca ggaagccatc     240

gcccagatcc tcgatttcat ttcagcacag actctcaccc cgatcctggg catccacggg     300

ggctcctcta tgataatggc agataaggat gaatcctcca tgttcttcca gtttggccca     360

tcaattgaac agcaagcttc cgtaatgctc aacatcatgg aagaatatga ctggtacatc     420

ttttctatcg tcaccaccta tttccctggc taccaggact ttgtaaacaa gatccgcagc     480

accattgaga atagctttgt gggctgggag ctagaggagg tcctcctact ggacatgtcc     540

ctggacgatg gagattctaa gatccagaat cagctcaaga aacttcaaag ccccatcatt     600

cttctttact gtaccaagga agaagccacc tacatctttg aagtggccaa ctcagtaggg     660

ctgactggct atggctacac gtggatcgtg cccagtctgg tggcagggga tacagacaca     720

gtgcctgcgg agttccccac tgggctcatc tctgtatcat atgatgaatg ggactatggc     780

ctccccgcca gagtgagaga tggaattgcc ataatcacca ctgctgcttc tgacatgctg     840

tctgagcaca gcttcatccc tgagcccaaa agcagttgtt acaacaccca cgagaagaga     900

atctaccagt ccaatatgct aaataggtat ctgatcaatg tcacttttga ggggaggaat     960

ttgtccttca gtgaagatgg ctaccagatg cacccgaaac tggtgataat tcttctgaac    1020

aaggagagga agtgggaaag ggtggggaag tggaaagaca agtccctgca gatgaagtac    1080

tatgtgtggc cccgaatgtg tccagagact gaagagcag                           1119


<210> 71
<211> 1920
<212> DNA
<213> Artificial Sequence


<220> 
<223> DNA seq of fusion protein #5 N2A-ATD-Fc

<400> 71
atgggcagag tgggctattg gaccctgctg gtgctgccgg cccttctggt ctggcgcggt      60

ccggcgccga gcgcggcggc ggagaagggt ccccccgcgc taaatattgc ggtgatgctg     120

ggtcacagcc acgacgtgac agagcgcgaa cttcgaacac tgtggggccc cgagcaggcg     180

gcggggctgc ccctggacgt gaacgtggta gctctgctga tgaaccgcac cgaccccaag     240

agcctcatca cgcacgtgtg cgacctcatg tccggggcac gcatccacgg cctcgtgttt     300

ggggacgaca cggaccagga ggccgtagcc cagatgctgg attttatctc ctcccacacc     360

ttcgtcccca tcttgggcat tcatgggggc gcatctatga tcatggctga caaggatccg     420

acgtctacct tcttccagtt tggagcgtcc atccagcagc aagccacggt catgctgaag     480

atcatgcagg attatgactg gcatgtcttc tccctggtga ccactatctt ccctggctac     540

agggaattca tcagcttcgt caagaccaca gtggacaaca gctttgtggg ctgggacatg     600

cagaatgtga tcacactgga cacttccttt gaggatgcaa agacacaagt ccagctgaag     660

aagatccact cttctgtcat cttgctctac tgttccaaag acgaggctgt tctcattctg     720

agtgaggccc gctcccttgg cctcaccggg tatgatttct tctggattgt ccccagcttg     780

gtctctggga acacggagct catcccaaaa gagtttccat cgggactcat ttctgtctcc     840

tacgatgact gggactacag cctggaggcg agagtgaggg acggcattgg catcctaacc     900

accgctgcat cttctatgct ggagaagttc tcctacatcc ccgaggccaa ggccagctgc     960

tacgggcaga tggagaggcc agaggtcccg atgcacacct tgcacccatt tatggtcaat    1020

gttacatggg atggcaaaga cttatccttc actgaggaag gctaccaggt gcaccccagg    1080

ctggtggtga ttgtgctgaa caaagaccgg gaatgggaaa aggtgggcaa gtgggagaac    1140

catacgctga gcctgaggca cgccgtgtgg cccaggtaca agtccttctc cgactgtgag    1200

ccggatgaca accatctcag catcggctcg agcaccatgg ttagatctag caagcccacg    1260

tgcccacccc ctgaactcct ggggggaccg tctgtcttca tcttcccccc aaaacccaag    1320

gacaccctca tgatctcacg cacccccgag gtcacatgcg tggtggtgga cgtgagccag    1380

gatgaccccg aggtgcagtt cacatggtac ataaacaacg agcaggtgcg caccgcccgg    1440

ccgccgctac gggagcagca gttcaacagc acgatccgcg tggtcagcac cctccccatc    1500

gcgcaccagg actggctgag gggcaaggag ttcaagtgca aagtccacaa caaggcactc    1560

ccggccccca tcgagaaaac catctccaaa gccagagggc agcccctgga gccgaaggtc    1620

tacaccatgg gccctccccg ggaggagctg agcagcaggt cggtcagcct gacctgcatg    1680

atcaacggct tctacccttc cgacatctcg gtggagtggg agaagaacgg gaaggcagag    1740

gacaactaca agaccacgcc ggccgtgctg gacagcgacg gctcctactt cctctacagc    1800

aagctctcag tgcccacgag tgagtggcag cggggcgacg tcttcacctg ctccgtgatg    1860

cacgaggcct tgcacaacca ctacacgcag aagtccatct cccgctctcc gggtaaatga    1920


<210> 72
<211> 1224
<212> DNA
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN2A (including signal sequence)

<400> 72
atgggcagag tgggctattg gaccctgctg gtgctgccgg cccttctggt ctggcgcggt      60

ccggcgccga gcgcggcggc ggagaagggt ccccccgcgc taaatattgc ggtgatgctg     120

ggtcacagcc acgacgtgac agagcgcgaa cttcgaacac tgtggggccc cgagcaggcg     180

gcggggctgc ccctggacgt gaacgtggta gctctgctga tgaaccgcac cgaccccaag     240

agcctcatca cgcacgtgtg cgacctcatg tccggggcac gcatccacgg cctcgtgttt     300

ggggacgaca cggaccagga ggccgtagcc cagatgctgg attttatctc ctcccacacc     360

ttcgtcccca tcttgggcat tcatgggggc gcatctatga tcatggctga caaggatccg     420

acgtctacct tcttccagtt tggagcgtcc atccagcagc aagccacggt catgctgaag     480

atcatgcagg attatgactg gcatgtcttc tccctggtga ccactatctt ccctggctac     540

agggaattca tcagcttcgt caagaccaca gtggacaaca gctttgtggg ctgggacatg     600

cagaatgtga tcacactgga cacttccttt gaggatgcaa agacacaagt ccagctgaag     660

aagatccact cttctgtcat cttgctctac tgttccaaag acgaggctgt tctcattctg     720

agtgaggccc gctcccttgg cctcaccggg tatgatttct tctggattgt ccccagcttg     780

gtctctggga acacggagct catcccaaaa gagtttccat cgggactcat ttctgtctcc     840

tacgatgact gggactacag cctggaggcg agagtgaggg acggcattgg catcctaacc     900

accgctgcat cttctatgct ggagaagttc tcctacatcc ccgaggccaa ggccagctgc     960

tacgggcaga tggagaggcc agaggtcccg atgcacacct tgcacccatt tatggtcaat    1020

gttacatggg atggcaaaga cttatccttc actgaggaag gctaccaggt gcaccccagg    1080

ctggtggtga ttgtgctgaa caaagaccgg gaatgggaaa aggtgggcaa gtgggagaac    1140

catacgctga gcctgaggca cgccgtgtgg cccaggtaca agtccttctc cgactgtgag    1200

ccggatgaca accatctcag catc                                           1224


<210> 73
<211> 2211
<212> DNA
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN2A in NM_001134407

<400> 73
cccgcgctaa atattgcggt gatgctgggt cacagccacg acgtgacaga gcgcgaactt      60

cgaacactgt ggggccccga gcaggcggcg gggctgcccc tggacgtgaa cgtggtagct     120

ctgctgatga accgcaccga ccccaagagc ctcatcacgc acgtgtgcga cctcatgtcc     180

ggggcacgca tccacggcct cgtgtttggg gacgacacgg accaggaggc cgtagcccag     240

atgctggatt ttatctcctc ccacaccttc gtccccatct tgggcattca tgggggcgca     300

tctatgatca tggctgacaa ggatccgacg tctaccttct tccagtttgg agcgtccatc     360

cagcagcaag ccacggtcat gctgaagatc atgcaggatt atgactggca tgtcttctcc     420

ctggtgacca ctatcttccc tggctacagg gaattcatca gcttcgtcaa gaccacagtg     480

gacaacagct ttgtgggctg ggacatgcag aatgtgatca cactggacac ttcctttgag     540

gatgcaaaga cacaagtcca gctgaagaag atccactctt ctgtcatctt gctctactgt     600

tccaaagacg aggctgttct cattctgagt gaggcccgct cccttggcct caccgggtat     660

gatttcttct ggattgtccc cagcttggtc tctgggaaca cggagctcat cccaaaagag     720

tttccatcgg gactcatttc tgtctcctac gatgactggg actacagcct ggaggcgaga     780

gtgagggacg gcattggcat cctaaccacc gctgcatctt ctatgctgga gaagttctcc     840

tacatccccg aggccaaggc cagctgctac gggcagatgg agaggccaga ggtcccgatg     900

cacaccttgc acccatttat ggtcaatgtt acatgggatg gcaaagactt atccttcact     960

gaggaaggct accaggtgca ccccaggctg gtggtgattg tgctgaacaa agaccgggaa    1020

tgggaaaagg tgggcaagtg ggagaaccat acgctgagcc tgaggcacgc cgtgtggccc    1080

aggacgctcg ccctgctgtt ctcctgctcc gtcgcccgtg ccgcgtgcga ccccaagatc    1140

gtcaacattg gcgcggtgct gagcacgcgg aagcacgagc agatgttccg cgaggccgtg    1200

aaccaggcca acaagcggca cggctcctgg aagattcagc tcaatgccac ctccgtcacg    1260

cacaagccca acgccatcca gatggctctg tcggtgtgcg aggacctcat ctccagccag    1320

gtctacgcca tcctagttag ccatccacct acccccaacg accacttcac tcccacccct    1380

gtctcctaca cagccggctt ctaccgcata cccgtgctgg ggctgaccac ccgcatgtcc    1440

atctactcgg acaagagcat ccacctgagc ttcctgcgca ccgtgccgcc ctactcccac    1500

cagtccagcg tgtggtttga gatgatgcgt gtctacagct ggaaccacat catcctgctg    1560

gtcagcgacg accacgaggg ccgggcggct cagaaacgcc tggagacgct gctggaggag    1620

cgtgagtcca aggcagagaa ggtgctgcag tttgacccag ggaccaagaa cgtgacggcc    1680

ctgctgatgg aggcgaaaga gctggaggcc cgggtcatca tcctttctgc cagcgaggac    1740

gatgctgcca ctgtataccg cgcagccgcg atgctgaaca tgacgggctc cgggtacgtg    1800

tggctggtcg gcgagcgcga gatctcgggg aacgccctgc gctacgcccc agacggcatc    1860

ctcgggctgc agctcatcaa cggcaagaac gagtcggccc acatcagcga cgccgtgggc    1920

gtggtggccc aggccgtgca cgagctcctc gagaaggaga acatcaccga cccgccgcgg    1980

ggctgcgtgg gcaacaccaa catctggaag accgggccgc tcttcaagag agtgctgatg    2040

tcttccaagt atgcggatgg ggtgactggt cgcgtggagt tcaatgagga tggggaccgg    2100

aagttcgcca actacagcat catgaacctg cagaaccgca agctggtgca agtgggcatc    2160

tacaatggca cccacgtcat ccctaatgac aggaagatca tctggccagg c             2211


<210> 74
<211> 1920
<212> DNA
<213> Artificial Sequence


<220> 
<223> DNA seq of fusion protein #6 N2B-ATD-Fc

<400> 74
atgaagccca gagcggagtg ctgttctccc aagttctggt tggtgttggc cgtcctggcc      60

gtgtcaggca gcagagctcg ttctcagaag agccccccca gcattggcat tgctgtcatc     120

ctcgtgggca cttccgacga ggtggccatc aaggatgccc acgagaaaga tgatttccac     180

catctctccg tggtaccccg ggtggaactg gtagccatga atgagaccga cccaaagagc     240

atcatcaccc gcatctgtga tctcatgtct gaccggaaga tccagggggt ggtgtttgct     300

gatgacacag accaggaagc catcgcccag atcctcgatt tcatttcagc acagactctc     360

accccgatcc tgggcatcca cgggggctcc tctatgataa tggcagataa ggatgaatcc     420

tccatgttct tccagtttgg cccatcaatt gaacagcaag cttccgtaat gctcaacatc     480

atggaagaat atgactggta catcttttct atcgtcacca cctatttccc tggctaccag     540

gactttgtaa acaagatccg cagcaccatt gagaatagct ttgtgggctg ggagctagag     600

gaggtcctcc tactggacat gtccctggac gatggagatt ctaagatcca gaatcagctc     660

aagaaacttc aaagccccat cattcttctt tactgtacca aggaagaagc cacctacatc     720

tttgaagtgg ccaactcagt agggctgact ggctatggct acacgtggat cgtgcccagt     780

ctggtggcag gggatacaga cacagtgcct gcggagttcc ccactgggct catctctgta     840

tcatatgatg aatgggacta tggcctcccc gccagagtga gagatggaat tgccataatc     900

accactgctg cttctgacat gctgtctgag cacagcttca tccctgagcc caaaagcagt     960

tgttacaaca cccacgagaa gagaatctac cagtccaata tgctaaatag gtatctgatc    1020

aatgtcactt ttgaggggag gaatttgtcc ttcagtgaag atggctacca gatgcacccg    1080

aaactggtga taattcttct gaacaaggag aggaagtggg aaagggtggg gaagtggaaa    1140

gacaagtccc tgcagatgaa gtactatgtg tggccccgaa tgtgtccaga gactgaagag    1200

caggaggatg accatctgag cattggctcg agcaccatgg ttagatctag caagcccacg    1260

tgcccacccc ctgaactcct ggggggaccg tctgtcttca tcttcccccc aaaacccaag    1320

gacaccctca tgatctcacg cacccccgag gtcacatgcg tggtggtgga cgtgagccag    1380

gatgaccccg aggtgcagtt cacatggtac ataaacaacg agcaggtgcg caccgcccgg    1440

ccgccgctac gggagcagca gttcaacagc acgatccgcg tggtcagcac cctccccatc    1500

gcgcaccagg actggctgag gggcaaggag ttcaagtgca aagtccacaa caaggcactc    1560

ccggccccca tcgagaaaac catctccaaa gccagagggc agcccctgga gccgaaggtc    1620

tacaccatgg gccctccccg ggaggagctg agcagcaggt cggtcagcct gacctgcatg    1680

atcaacggct tctacccttc cgacatctcg gtggagtggg agaagaacgg gaaggcagag    1740

gacaactaca agaccacgcc ggccgtgctg gacagcgacg gctcctactt cctctacagc    1800

aagctctcag tgcccacgag tgagtggcag cggggcgacg tcttcacctg ctccgtgatg    1860

cacgaggcct tgcacaacca ctacacgcag aagtccatct cccgctctcc gggtaaatga    1920


<210> 75
<211> 1224
<212> DNA
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN2B (including signal sequence)

<400> 75
atgaagccca gagcggagtg ctgttctccc aagttctggt tggtgttggc cgtcctggcc      60

gtgtcaggca gcagagctcg ttctcagaag agccccccca gcattggcat tgctgtcatc     120

ctcgtgggca cttccgacga ggtggccatc aaggatgccc acgagaaaga tgatttccac     180

catctctccg tggtaccccg ggtggaactg gtagccatga atgagaccga cccaaagagc     240

atcatcaccc gcatctgtga tctcatgtct gaccggaaga tccagggggt ggtgtttgct     300

gatgacacag accaggaagc catcgcccag atcctcgatt tcatttcagc acagactctc     360

accccgatcc tgggcatcca cgggggctcc tctatgataa tggcagataa ggatgaatcc     420

tccatgttct tccagtttgg cccatcaatt gaacagcaag cttccgtaat gctcaacatc     480

atggaagaat atgactggta catcttttct atcgtcacca cctatttccc tggctaccag     540

gactttgtaa acaagatccg cagcaccatt gagaatagct ttgtgggctg ggagctagag     600

gaggtcctcc tactggacat gtccctggac gatggagatt ctaagatcca gaatcagctc     660

aagaaacttc aaagccccat cattcttctt tactgtacca aggaagaagc cacctacatc     720

tttgaagtgg ccaactcagt agggctgact ggctatggct acacgtggat cgtgcccagt     780

ctggtggcag gggatacaga cacagtgcct gcggagttcc ccactgggct catctctgta     840

tcatatgatg aatgggacta tggcctcccc gccagagtga gagatggaat tgccataatc     900

accactgctg cttctgacat gctgtctgag cacagcttca tccctgagcc caaaagcagt     960

tgttacaaca cccacgagaa gagaatctac cagtccaata tgctaaatag gtatctgatc    1020

aatgtcactt ttgaggggag gaatttgtcc ttcagtgaag atggctacca gatgcacccg    1080

aaactggtga taattcttct gaacaaggag aggaagtggg aaagggtggg gaagtggaaa    1140

gacaagtccc tgcagatgaa gtactatgtg tggccccgaa tgtgtccaga gactgaagag    1200

caggaggatg accatctgag catt                                           1224


<210> 76
<211> 3108
<212> DNA
<213> Artificial Sequence


<220> 
<223> DNA seq of fusion protein #7 N1-ATD-N2A-ATD-Fc

<400> 76
atgagcacca tgcgcctgct gacgctcgcc ctgctgttct cctgctccgt cgcccgtgcc      60

gcgtgcgacc ccaagatcgt caacattggc gcggtgctga gcacgcggaa gcacgagcag     120

atgttccgcg aggccgtgaa ccaggccaac aagcggcacg gctcctggaa gattcagctc     180

aatgccacct ccgtcacgca caagcccaac gccatccaga tggctctgtc ggtgtgcgag     240

gacctcatct ccagccaggt ctacgccatc ctagttagcc atccacctac ccccaacgac     300

cacttcactc ccacccctgt ctcctacaca gccggcttct accgcatacc cgtgctgggg     360

ctgaccaccc gcatgtccat ctactcggac aagagcatcc acctgagctt cctgcgcacc     420

gtgccgccct actcccacca gtccagcgtg tggtttgaga tgatgcgtgt ctacagctgg     480

aaccacatca tcctgctggt cagcgacgac cacgagggcc gggcggctca gaaacgcctg     540

gagacgctgc tggaggagcg tgagtccaag gcagagaagg tgctgcagtt tgacccaggg     600

accaagaacg tgacggccct gctgatggag gcgaaagagc tggaggcccg ggtcatcatc     660

ctttctgcca gcgaggacga tgctgccact gtataccgcg cagccgcgat gctgaacatg     720

acgggctccg ggtacgtgtg gctggtcggc gagcgcgaga tctcggggaa cgccctgcgc     780

tacgccccgg acggcatcct cgggctgcag ctcatcaacg gcaagaacga gtcggcccac     840

atcagcgacg ccgtaggcgt ggtggcccag gccgtgcacg agctcctcga gaaggagaac     900

atcaccgacc cgccgcgggg ctgcgtgggc aacaccaaca tctggaagac cgggccgctc     960

ttcaagagag tgctgatgtc ttccaagtat gcggatgggg tgactggtcg cgtggagttc    1020

aatgaggatg gggaccggaa gttcgccaac tacagcatca tgaacctgca gaaccgcaag    1080

ctggtgcaag tgggcatcta caatggcacc cacgtcatcc ctaatgacag gaagatcatc    1140

tggccaggcg gagagacaga gaagcctcga gggtaccaga tgtccaccag actgaagatt    1200

gggtcgactg gtggaggagg gtctggcgga ggtggttccg ggggcggagg atctggggcc    1260

gcttctagag agaagggtcc ccccgcgcta aatattgcgg tgatgctggg tcacagccac    1320

gacgtgacag agcgcgaact tcgaacactg tggggccccg agcaggcggc ggggctgccc    1380

ctggacgtga acgtggtagc tctgctgatg aaccgcaccg accccaagag cctcatcacg    1440

cacgtgtgcg acctcatgtc cggggcacgc atccacggcc tcgtgtttgg ggacgacacg    1500

gaccaggagg ccgtagccca gatgctggat tttatctcct cccacacctt cgtccccatc    1560

ttgggcattc atgggggcgc atctatgatc atggctgaca aggatccgac gtctaccttc    1620

ttccagtttg gagcgtccat ccagcagcaa gccacggtca tgctgaagat catgcaggat    1680

tatgactggc atgtcttctc cctggtgacc actatcttcc ctggctacag ggaattcatc    1740

agcttcgtca agaccacagt ggacaacagc tttgtgggct gggacatgca gaatgtgatc    1800

acactggaca cttcctttga ggatgcaaag acacaagtcc agctgaagaa gatccactct    1860

tctgtcatct tgctctactg ttccaaagac gaggctgttc tcattctgag tgaggcccgc    1920

tcccttggcc tcaccgggta tgatttcttc tggattgtcc ccagcttggt ctctgggaac    1980

acggagctca tcccaaaaga gtttccatcg ggactcattt ctgtctccta cgatgactgg    2040

gactacagcc tggaggcgag agtgagggac ggcattggca tcctaaccac cgctgcatct    2100

tctatgctgg agaagttctc ctacatcccc gaggccaagg ccagctgcta cgggcagatg    2160

gagaggccag aggtcccgat gcacaccttg cacccattta tggtcaatgt tacatgggat    2220

ggcaaagact tatccttcac tgaggaaggc taccaggtgc accccaggct ggtggtgatt    2280

gtgctgaaca aagaccggga atgggaaaag gtgggcaagt gggagaacca tacgctgagc    2340

ctgaggcacg ccgtgtggcc caggtacaag tccttctccg actgtgagcc ggatgacaac    2400

catctcagca tcggctcgag caccatggtt agatctagca agcccacgtg cccaccccct    2460

gaactcctgg ggggaccgtc tgtcttcatc ttccccccaa aacccaagga caccctcatg    2520

atctcacgca cccccgaggt cacatgcgtg gtggtggacg tgagccagga tgaccccgag    2580

gtgcagttca catggtacat aaacaacgag caggtgcgca ccgcccggcc gccgctacgg    2640

gagcagcagt tcaacagcac gatccgcgtg gtcagcaccc tccccatcgc gcaccaggac    2700

tggctgaggg gcaaggagtt caagtgcaaa gtccacaaca aggcactccc ggcccccatc    2760

gagaaaacca tctccaaagc cagagggcag cccctggagc cgaaggtcta caccatgggc    2820

cctccccggg aggagctgag cagcaggtcg gtcagcctga cctgcatgat caacggcttc    2880

tacccttccg acatctcggt ggagtgggag aagaacggga aggcagagga caactacaag    2940

accacgccgg ccgtgctgga cagcgacggc tcctacttcc tctacagcaa gctctcagtg    3000

cccacgagtg agtggcagcg gggcgacgtc ttcacctgct ccgtgatgca cgaggccttg    3060

cacaaccact acacgcagaa gtccatctcc cgctctccgg gtaaatga                 3108


<210> 77
<211> 1200
<212> DNA
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN1 (including signal sequence)

<400> 77
atgagcacca tgcgcctgct gacgctcgcc ctgctgttct cctgctccgt cgcccgtgcc      60

gcgtgcgacc ccaagatcgt caacattggc gcggtgctga gcacgcggaa gcacgagcag     120

atgttccgcg aggccgtgaa ccaggccaac aagcggcacg gctcctggaa gattcagctc     180

aatgccacct ccgtcacgca caagcccaac gccatccaga tggctctgtc ggtgtgcgag     240

gacctcatct ccagccaggt ctacgccatc ctagttagcc atccacctac ccccaacgac     300

cacttcactc ccacccctgt ctcctacaca gccggcttct accgcatacc cgtgctgggg     360

ctgaccaccc gcatgtccat ctactcggac aagagcatcc acctgagctt cctgcgcacc     420

gtgccgccct actcccacca gtccagcgtg tggtttgaga tgatgcgtgt ctacagctgg     480

aaccacatca tcctgctggt cagcgacgac cacgagggcc gggcggctca gaaacgcctg     540

gagacgctgc tggaggagcg tgagtccaag gcagagaagg tgctgcagtt tgacccaggg     600

accaagaacg tgacggccct gctgatggag gcgaaagagc tggaggcccg ggtcatcatc     660

ctttctgcca gcgaggacga tgctgccact gtataccgcg cagccgcgat gctgaacatg     720

acgggctccg ggtacgtgtg gctggtcggc gagcgcgaga tctcggggaa cgccctgcgc     780

tacgccccgg acggcatcct cgggctgcag ctcatcaacg gcaagaacga gtcggcccac     840

atcagcgacg ccgtaggcgt ggtggcccag gccgtgcacg agctcctcga gaaggagaac     900

atcaccgacc cgccgcgggg ctgcgtgggc aacaccaaca tctggaagac cgggccgctc     960

ttcaagagag tgctgatgtc ttccaagtat gcggatgggg tgactggtcg cgtggagttc    1020

aatgaggatg gggaccggaa gttcgccaac tacagcatca tgaacctgca gaaccgcaag    1080

ctggtgcaag tgggcatcta caatggcacc cacgtcatcc ctaatgacag gaagatcatc    1140

tggccaggcg gagagacaga gaagcctcga gggtaccaga tgtccaccag actgaagatt    1200


<210> 78
<211> 1143
<212> DNA
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN2A

<400> 78
gagaagggtc cccccgcgct aaatattgcg gtgatgctgg gtcacagcca cgacgtgaca      60

gagcgcgaac ttcgaacact gtggggcccc gagcaggcgg cggggctgcc cctggacgtg     120

aacgtggtag ctctgctgat gaaccgcacc gaccccaaga gcctcatcac gcacgtgtgc     180

gacctcatgt ccggggcacg catccacggc ctcgtgtttg gggacgacac ggaccaggag     240

gccgtagccc agatgctgga ttttatctcc tcccacacct tcgtccccat cttgggcatt     300

catgggggcg catctatgat catggctgac aaggatccga cgtctacctt cttccagttt     360

ggagcgtcca tccagcagca agccacggtc atgctgaaga tcatgcagga ttatgactgg     420

catgtcttct ccctggtgac cactatcttc cctggctaca gggaattcat cagcttcgtc     480

aagaccacag tggacaacag ctttgtgggc tgggacatgc agaatgtgat cacactggac     540

acttcctttg aggatgcaaa gacacaagtc cagctgaaga agatccactc ttctgtcatc     600

ttgctctact gttccaaaga cgaggctgtt ctcattctga gtgaggcccg ctcccttggc     660

ctcaccgggt atgatttctt ctggattgtc cccagcttgg tctctgggaa cacggagctc     720

atcccaaaag agtttccatc gggactcatt tctgtctcct acgatgactg ggactacagc     780

ctggaggcga gagtgaggga cggcattggc atcctaacca ccgctgcatc ttctatgctg     840

gagaagttct cctacatccc cgaggccaag gccagctgct acgggcagat ggagaggcca     900

gaggtcccga tgcacacctt gcacccattt atggtcaatg ttacatggga tggcaaagac     960

ttatccttca ctgaggaagg ctaccaggtg caccccaggc tggtggtgat tgtgctgaac    1020

aaagaccggg aatgggaaaa ggtgggcaag tgggagaacc atacgctgag cctgaggcac    1080

gccgtgtggc ccaggtacaa gtccttctcc gactgtgagc cggatgacaa ccatctcagc    1140

atc                                                                  1143


<210> 79
<211> 3105
<212> DNA
<213> Artificial Sequence


<220> 
<223> DNA seq of fusion protein #8 N1-ATD-N2B-ATD-Fc

<400> 79
atgagcacca tgcgcctgct gacgctcgcc ctgctgttct cctgctccgt cgcccgtgcc      60

gcgtgcgacc ccaagatcgt caacattggc gcggtgctga gcacgcggaa gcacgagcag     120

atgttccgcg aggccgtgaa ccaggccaac aagcggcacg gctcctggaa gattcagctc     180

aatgccacct ccgtcacgca caagcccaac gccatccaga tggctctgtc ggtgtgcgag     240

gacctcatct ccagccaggt ctacgccatc ctagttagcc atccacctac ccccaacgac     300

cacttcactc ccacccctgt ctcctacaca gccggcttct accgcatacc cgtgctgggg     360

ctgaccaccc gcatgtccat ctactcggac aagagcatcc acctgagctt cctgcgcacc     420

gtgccgccct actcccacca gtccagcgtg tggtttgaga tgatgcgtgt ctacagctgg     480

aaccacatca tcctgctggt cagcgacgac cacgagggcc gggcggctca gaaacgcctg     540

gagacgctgc tggaggagcg tgagtccaag gcagagaagg tgctgcagtt tgacccaggg     600

accaagaacg tgacggccct gctgatggag gcgaaagagc tggaggcccg ggtcatcatc     660

ctttctgcca gcgaggacga tgctgccact gtataccgcg cagccgcgat gctgaacatg     720

acgggctccg ggtacgtgtg gctggtcggc gagcgcgaga tctcggggaa cgccctgcgc     780

tacgccccgg acggcatcct cgggctgcag ctcatcaacg gcaagaacga gtcggcccac     840

atcagcgacg ccgtaggcgt ggtggcccag gccgtgcacg agctcctcga gaaggagaac     900

atcaccgacc cgccgcgggg ctgcgtgggc aacaccaaca tctggaagac cgggccgctc     960

ttcaagagag tgctgatgtc ttccaagtat gcggatgggg tgactggtcg cgtggagttc    1020

aatgaggatg gggaccggaa gttcgccaac tacagcatca tgaacctgca gaaccgcaag    1080

ctggtgcaag tgggcatcta caatggcacc cacgtcatcc ctaatgacag gaagatcatc    1140

tggccaggcg gagagacaga gaagcctcga gggtaccaga tgtccaccag actgaagatt    1200

gggtcgactg gtggaggagg gtctggcgga ggtggttccg ggggcggagg atctggggcc    1260

gcttctagac agaagagccc ccccagcatt ggcattgctg tcatcctcgt gggcacttcc    1320

gacgaggtgg ccatcaagga tgcccacgag aaagatgatt tccaccatct ctccgtggta    1380

ccccgggtgg aactggtagc catgaatgag accgacccaa agagcatcat cacccgcatc    1440

tgtgatctca tgtctgaccg gaagatccag ggggtggtgt ttgctgatga cacagaccag    1500

gaagccatcg cccagatcct cgatttcatt tcagcacaga ctctcacccc gatcctgggc    1560

atccacgggg gctcctctat gataatggca gataaggatg aatcctccat gttcttccag    1620

tttggcccat caattgaaca gcaagcttcc gtaatgctca acatcatgga agaatatgac    1680

tggtacatct tttctatcgt caccacctat ttccctggct accaggactt tgtaaacaag    1740

atccgcagca ccattgagaa tagctttgtg ggctgggagc tagaggaggt cctcctactg    1800

gacatgtccc tggacgatgg agattctaag atccagaatc agctcaagaa acttcaaagc    1860

cccatcattc ttctttactg taccaaggaa gaagccacct acatctttga agtggccaac    1920

tcagtagggc tgactggcta tggctacacg tggatcgtgc ccagtctggt ggcaggggat    1980

acagacacag tgcctgcgga gttccccact gggctcatct ctgtatcata tgatgaatgg    2040

gactatggcc tccccgccag agtgagagat ggaattgcca taatcaccac tgctgcttct    2100

gacatgctgt ctgagcacag cttcatccct gagcccaaaa gcagttgtta caacacccac    2160

gagaagagaa tctaccagtc caatatgcta aataggtatc tgatcaatgt cacttttgag    2220

gggaggaatt tgtccttcag tgaagatggc taccagatgc acccgaaact ggtgataatt    2280

cttctgaaca aggagaggaa gtgggaaagg gtggggaagt ggaaagacaa gtccctgcag    2340

atgaagtact atgtgtggcc ccgaatgtgt ccagagactg aagagcagga ggatgaccat    2400

ctgagcattg gctcgagcac catggttaga tctagcaagc ccacgtgccc accccctgaa    2460

ctcctggggg gaccgtctgt cttcatcttc cccccaaaac ccaaggacac cctcatgatc    2520

tcacgcaccc ccgaggtcac atgcgtggtg gtggacgtga gccaggatga ccccgaggtg    2580

cagttcacat ggtacataaa caacgagcag gtgcgcaccg cccggccgcc gctacgggag    2640

cagcagttca acagcacgat ccgcgtggtc agcaccctcc ccatcgcgca ccaggactgg    2700

ctgaggggca aggagttcaa gtgcaaagtc cacaacaagg cactcccggc ccccatcgag    2760

aaaaccatct ccaaagccag agggcagccc ctggagccga aggtctacac catgggccct    2820

ccccgggagg agctgagcag caggtcggtc agcctgacct gcatgatcaa cggcttctac    2880

ccttccgaca tctcggtgga gtgggagaag aacgggaagg cagaggacaa ctacaagacc    2940

acgccggccg tgctggacag cgacggctcc tacttcctct acagcaagct ctcagtgccc    3000

acgagtgagt ggcagcgggg cgacgtcttc acctgctccg tgatgcacga ggccttgcac    3060

aaccactaca cgcagaagtc catctcccgc tctccgggta aatga                    3105


<210> 80
<211> 1200
<212> DNA
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN1 (including signal sequence)

<400> 80
atgagcacca tgcgcctgct gacgctcgcc ctgctgttct cctgctccgt cgcccgtgcc      60

gcgtgcgacc ccaagatcgt caacattggc gcggtgctga gcacgcggaa gcacgagcag     120

atgttccgcg aggccgtgaa ccaggccaac aagcggcacg gctcctggaa gattcagctc     180

aatgccacct ccgtcacgca caagcccaac gccatccaga tggctctgtc ggtgtgcgag     240

gacctcatct ccagccaggt ctacgccatc ctagttagcc atccacctac ccccaacgac     300

cacttcactc ccacccctgt ctcctacaca gccggcttct accgcatacc cgtgctgggg     360

ctgaccaccc gcatgtccat ctactcggac aagagcatcc acctgagctt cctgcgcacc     420

gtgccgccct actcccacca gtccagcgtg tggtttgaga tgatgcgtgt ctacagctgg     480

aaccacatca tcctgctggt cagcgacgac cacgagggcc gggcggctca gaaacgcctg     540

gagacgctgc tggaggagcg tgagtccaag gcagagaagg tgctgcagtt tgacccaggg     600

accaagaacg tgacggccct gctgatggag gcgaaagagc tggaggcccg ggtcatcatc     660

ctttctgcca gcgaggacga tgctgccact gtataccgcg cagccgcgat gctgaacatg     720

acgggctccg ggtacgtgtg gctggtcggc gagcgcgaga tctcggggaa cgccctgcgc     780

tacgccccgg acggcatcct cgggctgcag ctcatcaacg gcaagaacga gtcggcccac     840

atcagcgacg ccgtaggcgt ggtggcccag gccgtgcacg agctcctcga gaaggagaac     900

atcaccgacc cgccgcgggg ctgcgtgggc aacaccaaca tctggaagac cgggccgctc     960

ttcaagagag tgctgatgtc ttccaagtat gcggatgggg tgactggtcg cgtggagttc    1020

aatgaggatg gggaccggaa gttcgccaac tacagcatca tgaacctgca gaaccgcaag    1080

ctggtgcaag tgggcatcta caatggcacc cacgtcatcc ctaatgacag gaagatcatc    1140

tggccaggcg gagagacaga gaagcctcga gggtaccaga tgtccaccag actgaagatt    1200


<210> 81
<211> 1140
<212> DNA
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN2B

<400> 81
cagaagagcc cccccagcat tggcattgct gtcatcctcg tgggcacttc cgacgaggtg      60

gccatcaagg atgcccacga gaaagatgat ttccaccatc tctccgtggt accccgggtg     120

gaactggtag ccatgaatga gaccgaccca aagagcatca tcacccgcat ctgtgatctc     180

atgtctgacc ggaagatcca gggggtggtg tttgctgatg acacagacca ggaagccatc     240

gcccagatcc tcgatttcat ttcagcacag actctcaccc cgatcctggg catccacggg     300

ggctcctcta tgataatggc agataaggat gaatcctcca tgttcttcca gtttggccca     360

tcaattgaac agcaagcttc cgtaatgctc aacatcatgg aagaatatga ctggtacatc     420

ttttctatcg tcaccaccta tttccctggc taccaggact ttgtaaacaa gatccgcagc     480

accattgaga atagctttgt gggctgggag ctagaggagg tcctcctact ggacatgtcc     540

ctggacgatg gagattctaa gatccagaat cagctcaaga aacttcaaag ccccatcatt     600

cttctttact gtaccaagga agaagccacc tacatctttg aagtggccaa ctcagtaggg     660

ctgactggct atggctacac gtggatcgtg cccagtctgg tggcagggga tacagacaca     720

gtgcctgcgg agttccccac tgggctcatc tctgtatcat atgatgaatg ggactatggc     780

ctccccgcca gagtgagaga tggaattgcc ataatcacca ctgctgcttc tgacatgctg     840

tctgagcaca gcttcatccc tgagcccaaa agcagttgtt acaacaccca cgagaagaga     900

atctaccagt ccaatatgct aaataggtat ctgatcaatg tcacttttga ggggaggaat     960

ttgtccttca gtgaagatgg ctaccagatg cacccgaaac tggtgataat tcttctgaac    1020

aaggagagga agtgggaaag ggtggggaag tggaaagaca agtccctgca gatgaagtac    1080

tatgtgtggc cccgaatgtg tccagagact gaagagcagg aggatgacca tctgagcatt    1140


<210> 82
<211> 3702
<212> DNA
<213> Homo sapiens


<220> 
<223> Human GluN2C NM_000835

<400> 82
atgggtgggg ccctggggcc ggccctgttg ctcacctcgc tcttcggtgc ctgggcaggg       60

ctgggtccgg ggcagggcga gcagggcatg acggtggccg tggtgtttag cagctcaggg      120

ccgccccagg cccagttccg tgcccgcctc accccccaga gcttcctgga cctacccctg      180

gagatccagc cgctcacagt tggggtcaac accaccaacc ccagcagcct cctcacccag      240

atctgcggcc tcctgggtgc tgcccacgtc cacggcattg tctttgagga caacgtggac      300

accgaggcgg tggcccagat ccttgacttc atctcctccc agacccatgt gcccatcctc      360

agcatcagcg gaggctctgc tgtggtcctc acccccaagg agccgggctc cgccttcctg      420

cagctgggcg tgtccctgga gcagcagctg caggtgctgt tcaaggtgct ggaagagtac      480

gactggagcg ccttcgccgt catcaccagc ctgcacccgg gccacgcgct cttcctggag      540

ggcgtgcgcg ccgtcgccga cgccagccac gtgagttggc ggctgctgga cgtggtcacg      600

ctggagctgg gcccgggagg gccgcgcgcg cgcacgcagc gcctgctgcg ccagctcgac      660

gcgcccgtgt ttgtggccta ctgctcgcgc gaggaggccg aggtgctctt cgccgaggcg      720

gcgcaggccg gtctggtggg gcccggccac gtgtggctgg tgcccaacct ggcgctgggc      780

agcaccgatg cgccccccgc caccttcccc gtgggcctca tcagcgtcgt caccgagagc      840

tggcgcctca gcctgcgcca gaaggtgcgc gacggcgtgg ccattctggc cctgggcgcc      900

cacagctact ggcgccagca tggaaccctg ccagccccgg ccggggactg ccgtgttcac      960

cctgggcccg tcagccctgc ccgggaggcc ttctacaggc acctactgaa tgtcacctgg     1020

gagggccgag acttctcctt cagccctggt gggtacctgg tccagcccac catggtggtg     1080

atcgccctca accggcaccg cctctgggag atggtggggc gctgggagca tggcgtccta     1140

tacatgaagt accccgtgtg gcctcgctac agtgcctctc tgcagcctgt ggtggacagt     1200

cggcacctga cggtggccac gctggaagag cggccctttg tcatcgtgga gagccctgac     1260

cctggcacag gaggctgtgt ccccaacacc gtgccctgcc gcaggcagag caaccacacc     1320

ttcagcagcg gggacgtggc cccctacacc aagctctgct gtaagggatt ctgcatcgac     1380

atcctcaaga agctggccag agtggtcaaa ttctcctacg acctgtacct ggtgaccaac     1440

ggcaagcatg gcaagcgggt gcgcggcgta tggaacggca tgattgggga ggtgtactac     1500

aagcgggcag acatggccat cggctccctc accatcaatg aggaacgctc cgagatcgta     1560

gacttctctg taccctttgt ggagacgggc atcagtgtga tggtggctcg cagcaatggc     1620

accgtctccc cctcggcctt cttggagcca tatagccctg cagtgtgggt gatgatgttt     1680

gtcatgtgcc tcactgtggt ggccatcacc gtcttcatgt tcgagtactt cagccctgtc     1740

agctacaacc agaacctcac cagaggcaag aagtccgggg gcccagcttt cactatcggc     1800

aagtccgtgt ggctgctgtg ggcgctggtc ttcaacaact cagtgcccat cgagaacccg     1860

cggggcacca ccagcaagat catggttctg gtctgggcct tctttgctgt catcttcctc     1920

gccagctaca cggccaacct ggccgccttc atgatccaag agcaatacat cgacactgtg     1980

tcgggcctca gtgacaagaa gtttcagcgg cctcaagatc agtacccacc tttccgcttc     2040

ggcacggtgc ccaacggcag cacggagcgg aacatccgca gtaactaccg tgacatgcac     2100

acccacatgg tcaagttcaa ccagcgctcg gtggaggacg cgctcaccag cctcaagatg     2160

gggaagctgg atgccttcat ctatgatgct gctgtcctca actacatggc aggcaaggac     2220

gagggctgca agctggtcac cattgggtct ggcaaggtct ttgctaccac tggctacggc     2280

atcgccatgc agaaggactc ccactggaag cgggccatag acctggcgct cttgcagttc     2340

ctgggggacg gagagacaca gaaactggag acagtgtggc tctcagggat ctgccagaat     2400

gagaagaacg aggtgatgag cagcaagctg gacatcgaca acatggcagg cgtcttctac     2460

atgctgctgg tggccatggg gctggccctg ctggtcttcg cctgggagca cctggtctac     2520

tggaagctgc gccactcggt gcccaactca tcccagctgg acttcctgct ggctttcagc     2580

aggggcatct acagctgctt cagcggggtg cagagcctcg ccagcccacc gcggcaggcc     2640

agcccggacc tcacggccag ctcggcccag gccagcgtgc tcaagatgct gcaggcagcc     2700

cgcgacatgg tgaccacggc gggcgtaagc agctccctgg accgcgccac tcgcaccatc     2760

gagaattggg gtggcggccg ccgtgcgccc ccaccgtccc cctgcccgac cccgcggtct     2820

ggccccagcc catgcctgcc cacccccgac ccgcccccag agccgagccc cacgggctgg     2880

ggaccgccag acgggggtcg cgcggcgctt gtgcgcaggg ctccgcagcc cccgggccgc     2940

cccccgacgc cggggccgcc cctgtccgac gtctcccgag tgtcgcgccg cccagcctgg     3000

gaggcgcggt ggccggtgcg gaccgggcac tgcgggaggc acctctcggc ctccgagcgg     3060

cccctgtcgc ccgcgcgctg tcactacagc tcctttcctc gagccgaccg atccggccgc     3120

cccttcctcc cgctcttccc ggagctggag gacctgccgc tgctcggtcc ggagcagctg     3180

gcccggcggg aggccctgct gcacgcggcc tgggcccggg gctcgcgccc gcgtcacgct     3240

tccctgccca gctccgtggc cgaggccttc gctcggccca gctcgctgcc cgctgggtgc     3300

accggccccg cctgcgcccg ccccgacggc cactcggcct gcaggcgctt ggcgcaggcg     3360

cagtcgatgt gcttgccgat ctaccgggag gcctgccagg agggcgagca ggcaggggcc     3420

cccgcctggc agcacagaca gcacgtctgc ctgcacgccc acgcccacct gccattttgc     3480

tggggggctg tctgtcctca ccttccaccc tgtgccagcc acggctcctg gctctccggg     3540

gcctgggggc ctctggggca caggggcagg actctggggc tgggcacagg ctacagagac     3600

agtgggggac tggacgagat cagcagggta gcccgtggga cgcaaggctt cccgggaccc     3660

tgcacctgga gacggatctc cagtctggag tcagaagtgt ga                        3702


<210> 83
<211> 1086
<212> DNA
<213> Homo sapiens


<220> 
<223> GluN2C ATD

<400> 83
cagggcatga cggtggccgt ggtgtttagc agctcagggc cgccccaggc ccagttccgt      60

gcccgcctca ccccccagag cttcctggac ctacccctgg agatccagcc gctcacagtt     120

ggggtcaaca ccaccaaccc cagcagcctc ctcacccaga tctgcggcct cctgggtgct     180

gcccacgtcc acggcattgt ctttgaggac aacgtggaca ccgaggcggt ggcccagatc     240

cttgacttca tctcctccca gacccatgtg cccatcctca gcatcagcgg aggctctgct     300

gtggtcctca cccccaagga gccgggctcc gccttcctgc agctgggcgt gtccctggag     360

cagcagctgc aggtgctgtt caaggtgctg gaagagtacg actggagcgc cttcgccgtc     420

atcaccagcc tgcacccggg ccacgcgctc ttcctggagg gcgtgcgcgc cgtcgccgac     480

gccagccacg tgagttggcg gctgctggac gtggtcacgc tggagctggg cccgggaggg     540

ccgcgcgcgc gcacgcagcg cctgctgcgc cagctcgacg cgcccgtgtt tgtggcctac     600

tgctcgcgcg aggaggccga ggtgctcttc gccgaggcgg cgcaggccgg tctggtgggg     660

cccggccacg tgtggctggt gcccaacctg gcgctgggca gcaccgatgc gccccccgcc     720

accttccccg tgggcctcat cagcgtcgtc accgagagct ggcgcctcag cctgcgccag     780

aaggtgcgcg acggcgtggc cattctggcc ctgggcgccc acagctactg gcgccagcat     840

ggaaccctgc cagccccggc cggggactgc cgtgttcacc ctgggcccgt cagccctgcc     900

cgggaggcct tctacaggca cctactgaat gtcacctggg agggccgaga cttctccttc     960

agccctggtg ggtacctggt ccagcccacc atggtggtga tcgccctcaa ccggcaccgc    1020

ctctgggaga tggtggggcg ctgggagcat ggcgtcctat acatgaagta ccccgtgtgg    1080

cctcgc                                                               1086


<210> 84
<211> 414
<212> DNA
<213> Homo sapiens


<220> 
<223> GluN2C S1

<400> 84
agtcggcacc tgacggtggc cacgctggaa gagcggccct ttgtcatcgt ggagagccct      60

gaccctggca caggaggctg tgtccccaac accgtgccct gccgcaggca gagcaaccac     120

accttcagca gcggggacgt ggccccctac accaagctct gctgtaaggg attctgcatc     180

gacatcctca agaagctggc cagagtggtc aaattctcct acgacctgta cctggtgacc     240

aacggcaagc atggcaagcg ggtgcgcggc gtatggaacg gcatgattgg ggaggtgtac     300

tacaagcggg cagacatggc catcggctcc ctcaccatca atgaggaacg ctccgagatc     360

gtagacttct ctgtaccctt tgtggagacg ggcatcagtg tgatggtggc tcgc           414


<210> 85
<211> 426
<212> DNA
<213> Homo sapiens


<220> 
<223> GluN2C S2

<400> 85
actgtgtcgg gcctcagtga caagaagttt cagcggcctc aagatcagta cccacctttc      60

cgcttcggca cggtgcccaa cggcagcacg gagcggaaca tccgcagtaa ctaccgtgac     120

atgcacaccc acatggtcaa gttcaaccag cgctcggtgg aggacgcgct caccagcctc     180

aagatgggga agctggatgc cttcatctat gatgctgctg tcctcaacta catggcaggc     240

aaggacgagg gctgcaagct ggtcaccatt gggtctggca aggtctttgc taccactggc     300

tacggcatcg ccatgcagaa ggactcccac tggaagcggg ccatagacct ggcgctcttg     360

cagttcctgg gggacggaga gacacagaaa ctggagacag tgtggctctc agggatctgc     420

cagaat                                                                426


<210> 86
<211> 2043
<212> DNA
<213> Artificial Sequence


<220> 
<223> GluN2C ecd incl. signal sequence and GT-linker between S1 and S2

<400> 86
atgggtgggg ccctggggcc ggccctgttg ctcacctcgc tcttcggtgc ctgggcaggg      60

ctgggtccgg ggcagggcga gcagggcatg acggtggccg tggtgtttag cagctcaggg     120

ccgccccagg cccagttccg tgcccgcctc accccccaga gcttcctgga cctacccctg     180

gagatccagc cgctcacagt tggggtcaac accaccaacc ccagcagcct cctcacccag     240

atctgcggcc tcctgggtgc tgcccacgtc cacggcattg tctttgagga caacgtggac     300

accgaggcgg tggcccagat ccttgacttc atctcctccc agacccatgt gcccatcctc     360

agcatcagcg gaggctctgc tgtggtcctc acccccaagg agccgggctc cgccttcctg     420

cagctgggcg tgtccctgga gcagcagctg caggtgctgt tcaaggtgct ggaagagtac     480

gactggagcg ccttcgccgt catcaccagc ctgcacccgg gccacgcgct cttcctggag     540

ggcgtgcgcg ccgtcgccga cgccagccac gtgagttggc ggctgctgga cgtggtcacg     600

ctggagctgg gcccgggagg gccgcgcgcg cgcacgcagc gcctgctgcg ccagctcgac     660

gcgcccgtgt ttgtggccta ctgctcgcgc gaggaggccg aggtgctctt cgccgaggcg     720

gcgcaggccg gtctggtggg gcccggccac gtgtggctgg tgcccaacct ggcgctgggc     780

agcaccgatg cgccccccgc caccttcccc gtgggcctca tcagcgtcgt caccgagagc     840

tggcgcctca gcctgcgcca gaaggtgcgc gacggcgtgg ccattctggc cctgggcgcc     900

cacagctact ggcgccagca tggaaccctg ccagccccgg ccggggactg ccgtgttcac     960

cctgggcccg tcagccctgc ccgggaggcc ttctacaggc acctactgaa tgtcacctgg    1020

gagggccgag acttctcctt cagccctggt gggtacctgg tccagcccac catggtggtg    1080

atcgccctca accggcaccg cctctgggag atggtggggc gctgggagca tggcgtccta    1140

tacatgaagt accccgtgtg gcctcgctac agtgcctctc tgcagcctgt ggtggacagt    1200

cggcacctga cggtggccac gctggaagag cggccctttg tcatcgtgga gagccctgac    1260

cctggcacag gaggctgtgt ccccaacacc gtgccctgcc gcaggcagag caaccacacc    1320

ttcagcagcg gggacgtggc cccctacacc aagctctgct gtaagggatt ctgcatcgac    1380

atcctcaaga agctggccag agtggtcaaa ttctcctacg acctgtacct ggtgaccaac    1440

ggcaagcatg gcaagcgggt gcgcggcgta tggaacggca tgattgggga ggtgtactac    1500

aagcgggcag acatggccat cggctccctc accatcaatg aggaacgctc cgagatcgta    1560

gacttctctg taccctttgt ggagacgggc atcagtgtga tggtggctcg cggcaccact    1620

gtgtcgggcc tcagtgacaa gaagtttcag cggcctcaag atcagtaccc acctttccgc    1680

ttcggcacgg tgcccaacgg cagcacggag cggaacatcc gcagtaacta ccgtgacatg    1740

cacacccaca tggtcaagtt caaccagcgc tcggtggagg acgcgctcac cagcctcaag    1800

atggggaagc tggatgcctt catctatgat gctgctgtcc tcaactacat ggcaggcaag    1860

gacgagggct gcaagctggt caccattggg tctggcaagg tctttgctac cactggctac    1920

ggcatcgcca tgcagaagga ctcccactgg aagcgggcca tagacctggc gctcttgcag    1980

ttcctggggg acggagagac acagaaactg gagacagtgt ggctctcagg gatctgccag    2040

aat                                                                  2043


<210> 87
<211> 4011
<212> DNA
<213> Homo sapiens


<220> 
<223> Human GluN2D U77783 (DNA)

<400> 87
atgcgcggcg ccggtggccc ccgcggccct cggggccccg ctaagatgct gctgctgctg       60

gcgctggcct gcgccagccc gttcccggag gaggcgccgg ggccgggcgg ggccggtggg      120

cccggcggcg gcctcggcgg ggcgcggccg ctcaacgtgg cgctcgtgtt ctcggggccc      180

gcgtacgcgg ccgaggcggc acgcctgggc ccggccgtgg cggcggcggt gcgcagcccg      240

ggcctagacg tgcggcccgt ggcgctggtg ctcaacggct cggacccgcg cagcctcgtg      300

ctgcagctct gcgacctgct gtcggggttg cgcgtgcacg gcgtggtctt cgaagacgac      360

tcgcgcgcgc ccgccgtcgc gcccatcctc gacttcctgt cggcgcagac ctcgctgccc      420

atcgtggccg tgcacggcgg cgccgcgctc gtgctcacgc ccaaggagaa gggctccacc      480

ttcctgcagc tgggctcttc caccgagcaa cagcttcagg tcatctttga ggtgctggag      540

gagtatgact ggacgtcctt tgtagccgtg accactcgtg cccctggcca ccgggccttc      600

ctgtcctaca ttgaggtgct gactgacggt agtctggtgg gctgggagca ccgcggagcg      660

ctgacgctgg accctggggc gggcgaggcc gtgctcagtg cccagctccg cagtgtcagc      720

gcgcagatcc gcctgctctt ctgcgcccga gaggaggccg agcccgtgtt ccgcgcagct      780

gaggaggctg gcctcactgg atctggctac gtctggttca tggtggggcc ccagctggct      840

ggaggcgggg gctctggggc ccctggtgag ccccctcttc tgccaggagg cgcccccctg      900

cctgccgggc tgtttgcagt gcgctcggct ggctggcggg atgacctggc tcggcgagtg      960

gcagctggcg tggccgtagt ggccagaggt gcccaggccc tgctgcgtga ttatggtttc     1020

cttcctgagc tcggccacga ctgtcgcgcc cagaaccgca cccaccgcgg cgagagtctg     1080

cataggtact tcatgaacat cacgtgggat aaccgggatt actccttcaa tgaggacggc     1140

ttcctagtga acccctccct ggtggtcatc tccctcacca gagacaggac gtgggaggtg     1200

gtgggcagct gggagcagca gacgctccgc ctcaagtacc cgctgtggtc ccgctatggt     1260

cgcttcctgc agccagtgga cgacacgcag cacctcacgg tggccacgct ggaggaaagg     1320

ccgtttgtca tcgtggagcc tgcagaccct atcagcggca cctgcatccg agactccgtc     1380

ccctgccgga gccagctcaa ccgaacccac agccctccac cggatgcccc ccgcccggaa     1440

aagcgctgct gcaagggttt ctgcatcgac attctgaagc ggctggcgca taccatcggc     1500

ttcagctacg acctctacct ggtcaccaat ggcaagcacg gaaagaagat cgatggcgtc     1560

tggaacggca tgatcgggga ggtgttctac cagcgcgcag acatggccat cggctccctc     1620

accatcaacg aggagcgctc cgagatcgtg gacttctccg tccccttcgt ggagaccggc     1680

atcagcgtca tggtggcgcg cagcaatggc acggtgtccc cctcggcctt cctcgagccc     1740

tacagccccg ccgtgtgggt gatgatgttc gtcatgtgcc tcactgtggt cgccgtcact     1800

gttttcatct tcgagtacct cagtcctgtt ggttacaacc gcagcctggc cacgggcaag     1860

cgccctggcg gttcaacctt caccattggg aaatccatct ggctgctctg ggccctggtg     1920

ttcaataatt cggtgcccgt ggagaacccc cggggaacca ccagcaaaat catggtgctg     1980

gtgtgggcct tcttcgccgt catcttcctc gccagctaca cagccaacct ggccgccttc     2040

atgatccagg aggagtacgt ggatactgtg tctgggctca gtgaccgcaa gttccagagg     2100

ccccaggagc agtacccgcc cctgaagttt gggaccgtgc ccaacggctc cacggagaag     2160

aacatccgca gcaactatcc cgacatgcac agctacatgg tgcgctacaa ccagccccgc     2220

gtagaggaag cgctcactca gctcaaggca gggaagctgg acgccttcat ctacgatgct     2280

gcagtgctca attacatggc ccgcaaggac gagggctgca agcttgtcac catcggctcc     2340

ggcaaggtct tcgccacgac aggctatggc atcgccctgc acaagggctc ccgctggaag     2400

cggcccatcg acctggcgtt gctgcagttc ctgggggatg atgagatcga gatgctggag     2460

cggctgtggc tctctgggat ctgccacaat gacaaaatcg aggtgatgag cagcaagctg     2520

gacatcgaca acatggcggg cgtcttctac atgctcctgg tggccatggg cctgtccctg     2580

ctggtcttcg cctgggagca cctggtgtac tggcgcctgc ggcactgcct ggggcccacc     2640

caccgcatgg acttcctgct ggccttctcc aggggcatgt acagctgctg cagcgctgag     2700

gccgccccac cgcccgccaa gcccccgccg ccgccacagc ccctgcccag ccccgcgtac     2760

cccgcgccgg ggccggctcc cgggcccgca cctttcgtgc cccgcgagcg cgcctcagtg     2820

gaccgctggc gccggaccaa gggcgcgggg ccgccggggg gcgcgggcct ggccgacggc     2880

ttccaccgct actacggccc catcgagccg cagggcctag gcctcggcct gggcgaagcg     2940

cgcgcggcac cgcggggcgc agccgggcgc ccgctgtccc cgccggccgc tcagcccccg     3000

cagaagccgc cggcctccta tttcgccatc gtacgcgaca aggagccagc cgagcccccc     3060

gccggcgcct tccccggctt cccgtcgccg cccgcgcccc ccgccgccgc ggccaccgcc     3120

gtcgggccgc cactctgccg cttggccttc gaggacgaga gcccgccggc gcccgcgcgg     3180

tggccgcgct cggaccccga gagccaaccc ctgctggggc caggcgcggg cggcgcgggg     3240

ggcacggggg gcgcaggcgg aggagccccg gccgctccgc ccccgtgctg cgccgcgccg     3300

cccccgtgcc cttacctcga tctcgagccg tcgccgtcgg actcggagga ctcggagagc     3360

ctgggcggcg cgtcgctggg cggcctggat ccctggtggt tcgccgactt cccttacccg     3420

tatgccgagc gcctcgggcc gccgcccggc cgctactggt cggtcgacaa gctcgggggc     3480

tggcgcgccg ggagctggga ctacctgccc ccgcgcagcg gtccggccgc ctggcactgt     3540

cggcactgcg ccagcctgga gctgctgccg ccgccgcgcc atctcagctg ctcgcacgat     3600

ggcctggacg gcggctggtg ggcgccaccg cctccaccct gggccgccgg gcccctgccc     3660

cgacgccggg cccgctgcgg gtgcccgcgg tcgcacccgc accgcccgcg ggcctcgcac     3720

cgcacgcccg ccgctgccgc gccccaccac cacaggcacc ggcgcgccgc tgggggctgg     3780

gacctcccgc cgcccgcgcc cacctcgcgc tcgctcgagg acctcagctc gtgccctcgc     3840

gccgcccctg cgcgcaggct taccgggccc tcccgccacg ctcgcaggtg tccgcacgcc     3900

gcgcactggg ggccgccgct gcccacagct tcccaccgga gacaccgggg cggggacctg     3960

ggcacccgca ggggctcggc gcacttctct agcctcgagt ccgaggtatg a              4011


<210> 88
<211> 1110
<212> DNA
<213> Homo sapiens


<220> 
<223> GluN2D ATD

<400> 88
cggccgctca acgtggcgct cgtgttctcg gggcccgcgt acgcggccga ggcggcacgc      60

ctgggcccgg ccgtggcggc ggcggtgcgc agcccgggcc tagacgtgcg gcccgtggcg     120

ctggtgctca acggctcgga cccgcgcagc ctcgtgctgc agctctgcga cctgctgtcg     180

gggttgcgcg tgcacggcgt ggtcttcgaa gacgactcgc gcgcgcccgc cgtcgcgccc     240

atcctcgact tcctgtcggc gcagacctcg ctgcccatcg tggccgtgca cggcggcgcc     300

gcgctcgtgc tcacgcccaa ggagaagggc tccaccttcc tgcagctggg ctcttccacc     360

gagcaacagc ttcaggtcat ctttgaggtg ctggaggagt atgactggac gtcctttgta     420

gccgtgacca ctcgtgcccc tggccaccgg gccttcctgt cctacattga ggtgctgact     480

gacggtagtc tggtgggctg ggagcaccgc ggagcgctga cgctggaccc tggggcgggc     540

gaggccgtgc tcagtgccca gctccgcagt gtcagcgcgc agatccgcct gctcttctgc     600

gcccgagagg aggccgagcc cgtgttccgc gcagctgagg aggctggcct cactggatct     660

ggctacgtct ggttcatggt ggggccccag ctggctggag gcgggggctc tggggcccct     720

ggtgagcccc ctcttctgcc aggaggcgcc cccctgcctg ccgggctgtt tgcagtgcgc     780

tcggctggct ggcgggatga cctggctcgg cgagtggcag ctggcgtggc cgtagtggcc     840

agaggtgccc aggccctgct gcgtgattat ggtttccttc ctgagctcgg ccacgactgt     900

cgcgcccaga accgcaccca ccgcggcgag agtctgcata ggtacttcat gaacatcacg     960

tgggataacc gggattactc cttcaatgag gacggcttcc tagtgaaccc ctccctggtg    1020

gtcatctccc tcaccagaga caggacgtgg gaggtggtgg gcagctggga gcagcagacg    1080

ctccgcctca agtacccgct gtggtcccgc                                     1110


<210> 89
<211> 417
<212> DNA
<213> Homo sapiens


<220> 
<223> GluN2D S1

<400> 89
acgcagcacc tcacggtggc cacgctggag gaaaggccgt ttgtcatcgt ggagcctgca      60

gaccctatca gcggcacctg catccgagac tccgtcccct gccggagcca gctcaaccga     120

acccacagcc ctccaccgga tgccccccgc ccggaaaagc gctgctgcaa gggtttctgc     180

atcgacattc tgaagcggct ggcgcatacc atcggcttca gctacgacct ctacctggtc     240

accaatggca agcacggaaa gaagatcgat ggcgtctgga acggcatgat cggggaggtg     300

ttctaccagc gcgcagacat ggccatcggc tccctcacca tcaacgagga gcgctccgag     360

atcgtggact tctccgtccc cttcgtggag accggcatca gcgtcatggt ggcgcgc        417


<210> 90
<211> 426
<212> DNA
<213> Homo sapiens


<220> 
<223> GluN2D S2

<400> 90
actgtgtctg ggctcagtga ccgcaagttc cagaggcccc aggagcagta cccgcccctg      60

aagtttggga ccgtgcccaa cggctccacg gagaagaaca tccgcagcaa ctatcccgac     120

atgcacagct acatggtgcg ctacaaccag ccccgcgtag aggaagcgct cactcagctc     180

aaggcaggga agctggacgc cttcatctac gatgctgcag tgctcaatta catggcccgc     240

aaggacgagg gctgcaagct tgtcaccatc ggctccggca aggtcttcgc cacgacaggc     300

tatggcatcg ccctgcacaa gggctcccgc tggaagcggc ccatcgacct ggcgttgctg     360

cagttcctgg gggatgatga gatcgagatg ctggagcggc tgtggctctc tgggatctgc     420

cacaat                                                                426


<210> 91
<211> 2133
<212> DNA
<213> Artificial Sequence


<220> 
<223> GluN2D ecd incl. signal sequence and GT-linker between S1 and S2

<400> 91
atgcgcggcg ccggtggccc ccgcggccct cggggccccg ctaagatgct gctgctgctg      60

gcgctggcct gcgccagccc gttcccggag gaggcgccgg ggccgggcgg ggccggtggg     120

cccggcggcg gcctcggcgg ggcgcggccg ctcaacgtgg cgctcgtgtt ctcggggccc     180

gcgtacgcgg ccgaggcggc acgcctgggc ccggccgtgg cggcggcggt gcgcagcccg     240

ggcctagacg tgcggcccgt ggcgctggtg ctcaacggct cggacccgcg cagcctcgtg     300

ctgcagctct gcgacctgct gtcggggttg cgcgtgcacg gcgtggtctt cgaagacgac     360

tcgcgcgcgc ccgccgtcgc gcccatcctc gacttcctgt cggcgcagac ctcgctgccc     420

atcgtggccg tgcacggcgg cgccgcgctc gtgctcacgc ccaaggagaa gggctccacc     480

ttcctgcagc tgggctcttc caccgagcaa cagcttcagg tcatctttga ggtgctggag     540

gagtatgact ggacgtcctt tgtagccgtg accactcgtg cccctggcca ccgggccttc     600

ctgtcctaca ttgaggtgct gactgacggt agtctggtgg gctgggagca ccgcggagcg     660

ctgacgctgg accctggggc gggcgaggcc gtgctcagtg cccagctccg cagtgtcagc     720

gcgcagatcc gcctgctctt ctgcgcccga gaggaggccg agcccgtgtt ccgcgcagct     780

gaggaggctg gcctcactgg atctggctac gtctggttca tggtggggcc ccagctggct     840

ggaggcgggg gctctggggc ccctggtgag ccccctcttc tgccaggagg cgcccccctg     900

cctgccgggc tgtttgcagt gcgctcggct ggctggcggg atgacctggc tcggcgagtg     960

gcagctggcg tggccgtagt ggccagaggt gcccaggccc tgctgcgtga ttatggtttc    1020

cttcctgagc tcggccacga ctgtcgcgcc cagaaccgca cccaccgcgg cgagagtctg    1080

cataggtact tcatgaacat cacgtgggat aaccgggatt actccttcaa tgaggacggc    1140

ttcctagtga acccctccct ggtggtcatc tccctcacca gagacaggac gtgggaggtg    1200

gtgggcagct gggagcagca gacgctccgc ctcaagtacc cgctgtggtc ccgctatggt    1260

cgcttcctgc agccagtgga cgacacgcag cacctcacgg tggccacgct ggaggaaagg    1320

ccgtttgtca tcgtggagcc tgcagaccct atcagcggca cctgcatccg agactccgtc    1380

ccctgccgga gccagctcaa ccgaacccac agccctccac cggatgcccc ccgcccggaa    1440

aagcgctgct gcaagggttt ctgcatcgac attctgaagc ggctggcgca taccatcggc    1500

ttcagctacg acctctacct ggtcaccaat ggcaagcacg gaaagaagat cgatggcgtc    1560

tggaacggca tgatcgggga ggtgttctac cagcgcgcag acatggccat cggctccctc    1620

accatcaacg aggagcgctc cgagatcgtg gacttctccg tccccttcgt ggagaccggc    1680

atcagcgtca tggtggcgcg cggcaccact gtgtctgggc tcagtgaccg caagttccag    1740

aggccccagg agcagtaccc gcccctgaag tttgggaccg tgcccaacgg ctccacggag    1800

aagaacatcc gcagcaacta tcccgacatg cacagctaca tggtgcgcta caaccagccc    1860

cgcgtagagg aagcgctcac tcagctcaag gcagggaagc tggacgcctt catctacgat    1920

gctgcagtgc tcaattacat ggcccgcaag gacgagggct gcaagcttgt caccatcggc    1980

tccggcaagg tcttcgccac gacaggctat ggcatcgccc tgcacaaggg ctcccgctgg    2040

aagcggccca tcgacctggc gttgctgcag ttcctggggg atgatgagat cgagatgctg    2100

gagcggctgt ggctctctgg gatctgccac aat                                 2133


<210> 92
<211> 4395
<212> DNA
<213> Homo sapiens


<220> 
<223> Human GluN2A NM_001134407

<400> 92
atgggcagag tgggctattg gaccctgctg gtgctgccgg cccttctggt ctggcgcggt       60

ccggcgccga gcgcggcggc ggagaagggt ccccccgcgc taaatattgc ggtgatgctg      120

ggtcacagcc acgacgtgac agagcgcgaa cttcgaacac tgtggggccc cgagcaggcg      180

gcggggctgc ccctggacgt gaacgtggta gctctgctga tgaaccgcac cgaccccaag      240

agcctcatca cgcacgtgtg cgacctcatg tccggggcac gcatccacgg cctcgtgttt      300

ggggacgaca cggaccagga ggccgtagcc cagatgctgg attttatctc ctcccacacc      360

ttcgtcccca tcttgggcat tcatgggggc gcatctatga tcatggctga caaggatccg      420

acgtctacct tcttccagtt tggagcgtcc atccagcagc aagccacggt catgctgaag      480

atcatgcagg attatgactg gcatgtcttc tccctggtga ccactatctt ccctggctac      540

agggaattca tcagcttcgt caagaccaca gtggacaaca gctttgtggg ctgggacatg      600

cagaatgtga tcacactgga cacttccttt gaggatgcaa agacacaagt ccagctgaag      660

aagatccact cttctgtcat cttgctctac tgttccaaag acgaggctgt tctcattctg      720

agtgaggccc gctcccttgg cctcaccggg tatgatttct tctggattgt ccccagcttg      780

gtctctggga acacggagct catcccaaaa gagtttccat cgggactcat ttctgtctcc      840

tacgatgact gggactacag cctggaggcg agagtgaggg acggcattgg catcctaacc      900

accgctgcat cttctatgct ggagaagttc tcctacatcc ccgaggccaa ggccagctgc      960

tacgggcaga tggagaggcc agaggtcccg atgcacacct tgcacccatt tatggtcaat     1020

gttacatggg atggcaaaga cttatccttc actgaggaag gctaccaggt gcaccccagg     1080

ctggtggtga ttgtgctgaa caaagaccgg gaatgggaaa aggtgggcaa gtgggagaac     1140

catacgctga gcctgaggca cgccgtgtgg cccaggtaca agtccttctc cgactgtgag     1200

ccggatgaca accatctcag catcgtcacc ctggaggagg ccccattcgt catcgtggaa     1260

gacatagacc ccctgaccga gacgtgtgtg aggaacaccg tgccatgtcg gaagttcgtc     1320

aaaatcaaca attcaaccaa tgaggggatg aatgtgaaga aatgctgcaa ggggttctgc     1380

attgatattc tgaagaagct ttccagaact gtgaagttta cttacgacct ctatctggtg     1440

accaatggga agcatggcaa gaaagttaac aatgtgtgga atggaatgat cggtgaagtg     1500

gtctatcaac gggcagtcat ggcagttggc tcgctcacca tcaatgagga acgttctgaa     1560

gtggtggact tctctgtgcc ctttgtggaa acgggaatca gtgtcatggt ttcaagaagt     1620

aatggcaccg tctcaccttc tgcttttcta gaaccattca gcgcctctgt ctgggtgatg     1680

atgtttgtga tgctgctcat tgtttctgcc atagctgttt ttgtctttga atacttcagc     1740

cctgttggat acaacagaaa cttagccaaa gggaaagcac cccatgggcc ttcttttaca     1800

attggaaaag ctatatggct tctttggggc ctggtgttca ataactccgt gcctgtccag     1860

aatcctaaag ggaccaccag caagatcatg gtatctgtat gggccttctt cgctgtcata     1920

ttcctggcta gctacacagc caatctggct gccttcatga tccaagagga atttgtggac     1980

caagtgaccg gcctcagtga caaaaagttt cagagacctc atgactattc cccacctttt     2040

cgatttggga cagtgcctaa tggaagcacg gagagaaaca ttcggaataa ctatccctac     2100

atgcatcagt acatgaccaa atttaatcag aaaggagtag aggacgcctt ggtcagcctg     2160

aaaacgggga agctggacgc tttcatctac gatgccgcag tcttgaatta caaggctggg     2220

agggatgaag gctgcaagct ggtgaccatc gggagtgggt acatctttgc caccaccggt     2280

tatggaattg cccttcagaa aggctctcct tggaagaggc agatcgacct ggccttgctt     2340

cagtttgtgg gtgatggtga gatggaggag ctggagaccc tgtggctcac tgggatctgc     2400

cacaacgaga agaacgaggt gatgagcagc cagctggaca ttgacaacat ggcgggcgta     2460

ttctacatgc tggctgccgc catggccctt agcctcatca ccttcatctg ggagcacctc     2520

ttctactgga agctgcgctt ctgtttcacg ggcgtgtgct ccgaccggcc tgggttgctc     2580

ttctccatca gcaggggcat ctacagctgc attcatggag tgcacattga agaaaagaag     2640

aagtctccag acttcaatct gacgggatcc cagagcaaca tgttaaaact cctccggtca     2700

gccaaaaaca tttccagcat gtccaacatg aactcctcaa gaatggactc acccaaaaga     2760

gctgctgact tcatccaaag aggttccctc atcatggaca tggtttcaga taaggggaat     2820

ttgatgtact cagacaacag gtcctttcag gggaaagaga gcatttttgg agacaacatg     2880

aacgaactcc aaacatttgt ggccaaccgg cagaaggata acctcaataa ctatgtattc     2940

cagggacaac atcctcttac tctcaatgag tccaacccta acacggtgga ggtggccgtg     3000

agcacagaat ccaaagcgaa ctctagaccc cggcagctgt ggaagaaatc cgtggattcc     3060

atacgccagg attcactatc ccagaatcca gtctcccaga gggatgaggc aacagcagag     3120

aataggaccc actccctaaa gagccctagg tatcttccag aagagatggc ccactctgac     3180

atttcagaaa cgtcaaatcg ggccacgtgc cacagggaac ctgacaacag taagaaccac     3240

aaaaccaagg acaactttaa aaggtcagtg gcctccaaat accccaagga ctgtagtgag     3300

gtcgagcgca cctacctgaa aaccaaatca agctccccta gagacaagat ctacactata     3360

gatggtgaga aggagcctgg tttccactta gatccacccc agtttgttga aaatgtgacc     3420

ctgcccgaga acgtggactt cccggacccc taccaggatc ccagtgaaaa cttccgcaag     3480

ggggactcca cgctgccaat gaaccggaac cccttgcata atgaagaggg gctttccaac     3540

aacgaccagt ataaactcta ctccaagcac ttcaccttga aagacaaggg ttccccgcac     3600

agtgagacca gcgagcgata ccggcagaac tccacgcact gcagaagctg cctttccaac     3660

atgcccacct attcaggcca cttcaccatg aggtccccct tcaagtgcga tgcctgcctg     3720

cggatgggga acctctatga catcgatgaa gaccagatgc ttcaggagac aggtaaccca     3780

gccaccgggg agcaggtcta ccagcaggac tgggcacaga acaatgccct tcaattacaa     3840

aagaacaagc taaggattag ccgtcagcat tcctacgata acattgtcga caaacctagg     3900

gagctagacc ttagcaggcc ctcccggagc ataagcctca aggacaggga acggcttctg     3960

gagggaaatt tttacggcag cctgtttagt gtcccctcaa gcaaactctc ggggaaaaaa     4020

agctcccttt tcccccaagg tctggaggac agcaagagga gcaagtctct cttgccagac     4080

cacacctccg ataacccttt cctccactcc cacagggatg accaacgctt ggttattggg     4140

agatgcccct cggaccctta caaacactcg ttgccatccc aggcggtgaa tgacagctat     4200

cttcggtcgt ccttgaggtc aacggcatcg tactgttcca gggacagtcg gggccacaat     4260

gatgtgtata tttcggagca tgttatgcct tatgctgcaa ataagaataa tatgtactct     4320

acccccaggg ttttaaattc ctgcagcaat agacgcgtgt acaagaaaat gcctagtatc     4380

gaatctgatg tttaa                                                      4395


<210> 93
<211> 411
<212> DNA
<213> Homo sapiens


<220> 
<223> GluN2A S1

<400> 93
gacaaccatc tcagcatcgt caccctggag gaggccccat tcgtcatcgt ggaagacata      60

gaccccctga ccgagacgtg tgtgaggaac accgtgccat gtcggaagtt cgtcaaaatc     120

aacaattcaa ccaatgaggg gatgaatgtg aagaaatgct gcaaggggtt ctgcattgat     180

attctgaaga agctttccag aactgtgaag tttacttacg acctctatct ggtgaccaat     240

gggaagcatg gcaagaaagt taacaatgtg tggaatggaa tgatcggtga agtggtctat     300

caacgggcag tcatggcagt tggctcgctc accatcaatg aggaacgttc tgaagtggtg     360

gacttctctg tgccctttgt ggaaacggga atcagtgtca tggtttcaag a              411


<210> 94
<211> 426
<212> DNA
<213> Homo sapiens


<220> 
<223> GluN2A S2

<400> 94
caagtgaccg gcctcagtga caaaaagttt cagagacctc atgactattc cccacctttt      60

cgatttggga cagtgcctaa tggaagcacg gagagaaaca ttcggaataa ctatccctac     120

atgcatcagt acatgaccaa atttaatcag aaaggagtag aggacgcctt ggtcagcctg     180

aaaacgggga agctggacgc tttcatctac gatgccgcag tcttgaatta caaggctggg     240

agggatgaag gctgcaagct ggtgaccatc gggagtgggt acatctttgc caccaccggt     300

tatggaattg cccttcagaa aggctctcct tggaagaggc agatcgacct ggccttgctt     360

cagtttgtgg gtgatggtga gatggaggag ctggagaccc tgtggctcac tgggatctgc     420

cacaac                                                                426


<210> 95
<211> 2049
<212> DNA
<213> Artificial Sequence


<220> 
<223> GluN2A ecd incl. signal sequence and GT-linker between S1 and S2

<400> 95
atgggcagag tgggctattg gaccctgctg gtgctgccgg cccttctggt ctggcgcggt      60

ccggcgccga gcgcggcggc ggagaagggt ccccccgcgc taaatattgc ggtgatgctg     120

ggtcacagcc acgacgtgac agagcgcgaa cttcgaacac tgtggggccc cgagcaggcg     180

gcggggctgc ccctggacgt gaacgtggta gctctgctga tgaaccgcac cgaccccaag     240

agcctcatca cgcacgtgtg cgacctcatg tccggggcac gcatccacgg cctcgtgttt     300

ggggacgaca cggaccagga ggccgtagcc cagatgctgg attttatctc ctcccacacc     360

ttcgtcccca tcttgggcat tcatgggggc gcatctatga tcatggctga caaggatccg     420

acgtctacct tcttccagtt tggagcgtcc atccagcagc aagccacggt catgctgaag     480

atcatgcagg attatgactg gcatgtcttc tccctggtga ccactatctt ccctggctac     540

agggaattca tcagcttcgt caagaccaca gtggacaaca gctttgtggg ctgggacatg     600

cagaatgtga tcacactgga cacttccttt gaggatgcaa agacacaagt ccagctgaag     660

aagatccact cttctgtcat cttgctctac tgttccaaag acgaggctgt tctcattctg     720

agtgaggccc gctcccttgg cctcaccggg tatgatttct tctggattgt ccccagcttg     780

gtctctggga acacggagct catcccaaaa gagtttccat cgggactcat ttctgtctcc     840

tacgatgact gggactacag cctggaggcg agagtgaggg acggcattgg catcctaacc     900

accgctgcat cttctatgct ggagaagttc tcctacatcc ccgaggccaa ggccagctgc     960

tacgggcaga tggagaggcc agaggtcccg atgcacacct tgcacccatt tatggtcaat    1020

gttacatggg atggcaaaga cttatccttc actgaggaag gctaccaggt gcaccccagg    1080

ctggtggtga ttgtgctgaa caaagaccgg gaatgggaaa aggtgggcaa gtgggagaac    1140

catacgctga gcctgaggca cgccgtgtgg cccaggtaca agtccttctc cgactgtgag    1200

ccggatgaca accatctcag catcgtcacc ctggaggagg ccccattcgt catcgtggaa    1260

gacatagacc ccctgaccga gacgtgtgtg aggaacaccg tgccatgtcg gaagttcgtc    1320

aaaatcaaca attcaaccaa tgaggggatg aatgtgaaga aatgctgcaa ggggttctgc    1380

attgatattc tgaagaagct ttccagaact gtgaagttta cttacgacct ctatctggtg    1440

accaatggga agcatggcaa gaaagttaac aatgtgtgga atggaatgat cggtgaagtg    1500

gtctatcaac gggcagtcat ggcagttggc tcgctcacca tcaatgagga acgttctgaa    1560

gtggtggact tctctgtgcc ctttgtggaa acgggaatca gtgtcatggt ttcaagaggc    1620

acccaagtga ccggcctcag tgacaaaaag tttcagagac ctcatgacta ttccccacct    1680

tttcgatttg ggacagtgcc taatggaagc acggagagaa acattcggaa taactatccc    1740

tacatgcatc agtacatgac caaatttaat cagaaaggag tagaggacgc cttggtcagc    1800

ctgaaaacgg ggaagctgga cgctttcatc tacgatgccg cagtcttgaa ttacaaggct    1860

gggagggatg aaggctgcaa gctggtgacc atcgggagtg ggtacatctt tgccaccacc    1920

ggttatggaa ttgcccttca gaaaggctct ccttggaaga ggcagatcga cctggccttg    1980

cttcagtttg tgggtgatgg tgagatggag gagctggaga ccctgtggct cactgggatc    2040

tgccacaac                                                            2049


<210> 96
<211> 4455
<212> DNA
<213> Homo sapiens


<220> 
<223> Human GluN2B NM_000834

<400> 96
atgaagccca gagcggagtg ctgttctccc aagttctggt tggtgttggc cgtcctggcc       60

gtgtcaggca gcagagctcg ttctcagaag agccccccca gcattggcat tgctgtcatc      120

ctcgtgggca cttccgacga ggtggccatc aaggatgccc acgagaaaga tgatttccac      180

catctctccg tggtaccccg ggtggaactg gtagccatga atgagaccga cccaaagagc      240

atcatcaccc gcatctgtga tctcatgtct gaccggaaga tccagggggt ggtgtttgct      300

gatgacacag accaggaagc catcgcccag atcctcgatt tcatttcagc acagactctc      360

acccccatcc tgggcatcca cgggggctcc tctatgataa tggcagataa ggatgaatcc      420

tccatgttct tccagtttgg cccatcaatt gaacagcaag cttccgtaat gctcaacatc      480

atggaagaat atgactggta catcttttct atcgtcacca cctatttccc tggctaccag      540

gactttgtaa acaagatccg cagcaccatt gagaatagct ttgtgggctg ggagctagag      600

gaggtcctcc tactggacat gtccctggac gatggagatt ctaagatcca gaatcagctc      660

aagaaacttc aaagccccat cattcttctt tactgtacca aggaagaagc cacctacatc      720

tttgaagtgg ccaactcagt agggctgact ggctatggct acacgtggat cgtgcccagt      780

ctggtggcag gggatacaga cacagtgcct gcggagttcc ccactgggct catctctgta      840

tcatatgatg aatgggacta tggcctcccc gccagagtga gagatggaat tgccataatc      900

accactgctg cttctgacat gctgtctgag cacagcttca tccctgagcc caaaagcagt      960

tgttacaaca cccacgagaa gagaatctac cagtccaata tgctaaatag gtatctgatc     1020

aatgtcactt ttgaggggag gaatttgtcc ttcagtgaag atggctacca gatgcacccg     1080

aaactggtga taattcttct gaacaaggag aggaagtggg aaagggtggg gaagtggaaa     1140

gacaagtccc tgcagatgaa gtactatgtg tggccccgaa tgtgtccaga gactgaagag     1200

caggaggatg accatctgag cattgtgacc ctggaggagg caccatttgt cattgtggaa     1260

agtgtggacc ctctgagtgg aacctgcatg aggaacacag tcccctgcca aaaacgcata     1320

gtcactgaga ataaaacaga cgaggagccg ggttacatca aaaaatgctg caaggggttc     1380

tgtattgaca tccttaagaa aatttctaaa tctgtgaagt tcacctatga cctttacctg     1440

gttaccaatg gcaagcatgg gaagaaaatc aatggaacct ggaatggtat gattggagag     1500

gtggtcatga agagggccta catggcagtg ggctcactca ccatcaatga ggaacgatcg     1560

gaggtggtcg acttctctgt gcccttcata gagacaggca tcagtgtcat ggtgtcacgc     1620

agcaatggga ctgtctcacc ttctgccttc ttagagccat tcagcgctga cgtatgggtg     1680

atgatgtttg tgatgctgct catcgtctca gccgtggctg tctttgtctt tgagtacttc     1740

agccctgtgg gttataacag gtgcctcgct gatggcagag agcctggtgg accctctttc     1800

accatcggca aagctatttg gttgctctgg ggtctggtgt ttaacaactc cgtacctgtg     1860

cagaacccaa aggggaccac ctccaagatc atggtgtcag tgtgggcctt ctttgctgtc     1920

atcttcctgg ccagctacac tgccaactta gctgccttca tgatccaaga ggaatatgtg     1980

gaccaggttt ctggcctgag cgacaaaaag ttccagagac ctaatgactt ctcaccccct     2040

ttccgctttg ggaccgtgcc caacggcagc acagagagaa atattcgcaa taactatgca     2100

gaaatgcatg cctacatggg aaagttcaac cagaggggtg tagatgatgc attgctctcc     2160

ctgaaaacag ggaaactgga tgccttcatc tatgatgcag cagtgctgaa ctatatggca     2220

ggcagagatg aaggctgcaa gctggtgacc attggcagtg ggaaggtctt tgcttccact     2280

ggctatggca ttgccatcca aaaagattct gggtggaagc gccaggtgga ccttgctatc     2340

ctgcagctct ttggagatgg ggagatggaa gaactggaag ctctctggct cactggcatt     2400

tgtcacaatg agaagaatga ggtcatgagc agccagctgg acattgacaa catggcaggg     2460

gtcttctaca tgttgggggc ggccatggct ctcagcctca tcaccttcat ctgcgaacac     2520

cttttctatt ggcagttccg acattgcttt atgggtgtct gttctggcaa gcctggcatg     2580

gtcttctcca tcagcagagg tatctacagc tgcatccatg gggtggcgat cgaggagcgc     2640

cagtctgtaa tgaactcccc caccgcaacc atgaacaaca cacactccaa catcctgcgc     2700

ctgctgcgca cggccaagaa catggctaac ctgtctggtg tgaatggctc accgcagagc     2760

gccctggact tcatccgacg ggagtcatcc gtctatgaca tctcagagca ccgccgcagc     2820

ttcacgcatt ctgactgcaa atcctacaac aacccgccct gtgaggagaa cctcttcagt     2880

gactacatca gtgaggtaga gagaacgttc gggaacctgc agctgaagga cagcaacgtg     2940

taccaagatc actaccacca tcaccaccgg ccccatagta ttggcagtgc cagctccatc     3000

gatgggctct acgactgtga caacccaccc ttcaccaccc agtccaggtc catcagcaag     3060

aagcccctgg acatcggcct cccctcctcc aagcacagcc agctcagtga cctgtacggc     3120

aaattctcct tcaagagcga ccgctacagt ggccacgacg acttgatccg ctccgatgtc     3180

tctgacatct caacccacac cgtcacctat gggaacatcg agggcaatgc cgccaagagg     3240

cgtaagcagc aatataagga cagcctgaag aagcggcctg cctcggccaa gtcccgcagg     3300

gagtttgacg agatcgagct ggcctaccgt cgccgaccgc cccgctcccc tgaccacaag     3360

cgctacttca gggacaagga agggctacgg gacttctacc tggaccagtt ccgaacaaag     3420

gagaactcac cccactggga gcacgtagac ctgaccgaca tctacaagga gcggagtgat     3480

gactttaagc gcgactccgt cagcggagga gggccctgta ccaacaggtc tcacatcaag     3540

cacgggacgg gcgacaaaca cggcgtggtc agcggggtac ctgcaccttg ggagaagaac     3600

ctgaccaacg tggagtggga ggaccggtcc gggggcaact tctgccgcag ctgtccctcc     3660

aagctgcaca actactccac gacggtgacg ggtcagaact cgggcaggca ggcgtgcatc     3720

cggtgtgagg cttgcaagaa agcaggcaac ctgtatgaca tcagtgagga caactccctg     3780

caggaactgg accagccggc tgccccagtg gcggtgacgt caaacgcctc caccactaag     3840

taccctcaga gcccgactaa ttccaaggcc cagaagaaga accggaacaa actgcgccgg     3900

cagcactcct acgacacctt cgtggacctg cagaaggaag aagccgccct ggccccgcgc     3960

agcgtaagcc tgaaagacaa gggccgattc atggatggga gcccctacgc ccacatgttt     4020

gagatgtcag ctggcgagag cacctttgcc aacaacaagt cctcagtgcc cactgccgga     4080

catcaccacc acaacaaccc cggcggcggg tacatgctca gcaagtcgct ctaccctgac     4140

cgggtcacgc aaaacccttt catccccact tttggggacg accagtgctt gctccatggc     4200

agcaaatcct acttcttcag gcagcccacg gtggcggggg cgtcgaaagc caggccggac     4260

ttccgggccc ttgtcaccaa caagccggtg gtctcggccc ttcatggggc cgtgccagcc     4320

cgtttccaga aggacatctg tatagggaac cagtccaacc cctgtgtgcc taacaacaaa     4380

aaccccaggg ctttcaatgg ctccagcaat gggcatgttt atgagaaact ttctagtatt     4440

gagtctgatg tctga                                                      4455


<210> 97
<211> 2052
<212> DNA
<213> Artificial Sequence


<220> 
<223> GluN2B ecd incl. signal sequence and GT-linker between S1 and S2

<400> 97
atgaagccca gagcggagtg ctgttctccc aagttctggt tggtgttggc cgtcctggcc      60

gtgtcaggca gcagagctcg ttctcagaag agccccccca gcattggcat tgctgtcatc     120

ctcgtgggca cttccgacga ggtggccatc aaggatgccc acgagaaaga tgatttccac     180

catctctccg tggtaccccg ggtggaactg gtagccatga atgagaccga cccaaagagc     240

atcatcaccc gcatctgtga tctcatgtct gaccggaaga tccagggggt ggtgtttgct     300

gatgacacag accaggaagc catcgcccag atcctcgatt tcatttcagc acagactctc     360

acccccatcc tgggcatcca cgggggctcc tctatgataa tggcagataa ggatgaatcc     420

tccatgttct tccagtttgg cccatcaatt gaacagcaag cttccgtaat gctcaacatc     480

atggaagaat atgactggta catcttttct atcgtcacca cctatttccc tggctaccag     540

gactttgtaa acaagatccg cagcaccatt gagaatagct ttgtgggctg ggagctagag     600

gaggtcctcc tactggacat gtccctggac gatggagatt ctaagatcca gaatcagctc     660

aagaaacttc aaagccccat cattcttctt tactgtacca aggaagaagc cacctacatc     720

tttgaagtgg ccaactcagt agggctgact ggctatggct acacgtggat cgtgcccagt     780

ctggtggcag gggatacaga cacagtgcct gcggagttcc ccactgggct catctctgta     840

tcatatgatg aatgggacta tggcctcccc gccagagtga gagatggaat tgccataatc     900

accactgctg cttctgacat gctgtctgag cacagcttca tccctgagcc caaaagcagt     960

tgttacaaca cccacgagaa gagaatctac cagtccaata tgctaaatag gtatctgatc    1020

aatgtcactt ttgaggggag gaatttgtcc ttcagtgaag atggctacca gatgcacccg    1080

aaactggtga taattcttct gaacaaggag aggaagtggg aaagggtggg gaagtggaaa    1140

gacaagtccc tgcagatgaa gtactatgtg tggccccgaa tgtgtccaga gactgaagag    1200

caggaggatg accatctgag cattgtgacc ctggaggagg caccatttgt cattgtggaa    1260

agtgtggacc ctctgagtgg aacctgcatg aggaacacag tcccctgcca aaaacgcata    1320

gtcactgaga ataaaacaga cgaggagccg ggttacatca aaaaatgctg caaggggttc    1380

tgtattgaca tccttaagaa aatttctaaa tctgtgaagt tcacctatga cctttacctg    1440

gttaccaatg gcaagcatgg gaagaaaatc aatggaacct ggaatggtat gattggagag    1500

gtggtcatga agagggccta catggcagtg ggctcactca ccatcaatga ggaacgatcg    1560

gaggtggtcg acttctctgt gcccttcata gagacaggca tcagtgtcat ggtgtcacgc    1620

ggcacccagg tttctggcct gagcgacaaa aagttccaga gacctaatga cttctcaccc    1680

cctttccgct ttgggaccgt gcccaacggc agcacagaga gaaatattcg caataactat    1740

gcagaaatgc atgcctacat gggaaagttc aaccagaggg gtgtagatga tgcattgctc    1800

tccctgaaaa cagggaaact ggatgccttc atctatgatg cagcagtgct gaactatatg    1860

gcaggcagag atgaaggctg caagctggtg accattggca gtgggaaggt ctttgcttcc    1920

actggctatg gcattgccat ccaaaaagat tctgggtgga agcgccaggt ggaccttgct    1980

atcctgcagc tctttggaga tggggagatg gaagaactgg aagctctctg gctcactggc    2040

atttgtcaca at                                                        2052


<210> 98
<211> 636
<212> PRT
<213> Artificial Sequence


<220> 
<223> protein seq of fusion protein #9 N2C-ATD-Fc

<400> 98
Met Gly Gly Ala Leu Gly Pro Ala Leu Leu Leu Thr Ser Leu Phe Gly 
1               5                   10                  15      
Ala Trp Ala Gly Leu Gly Pro Gly Gln Gly Glu Gln Gly Met Thr Val 
            20                  25                  30          
Ala Val Val Phe Ser Ser Ser Gly Pro Pro Gln Ala Gln Phe Arg Ala 
        35                  40                  45              
Arg Leu Thr Pro Gln Ser Phe Leu Asp Leu Pro Leu Glu Ile Gln Pro 
    50                  55                  60                  
Leu Thr Val Gly Val Asn Thr Thr Asn Pro Ser Ser Leu Leu Thr Gln 
65                  70                  75                  80  
Ile Cys Gly Leu Leu Gly Ala Ala His Val His Gly Ile Val Phe Glu 
                85                  90                  95      
Asp Asn Val Asp Thr Glu Ala Val Ala Gln Ile Leu Asp Phe Ile Ser 
            100                 105                 110         
Ser Gln Thr His Val Pro Ile Leu Ser Ile Ser Gly Gly Ser Ala Val 
        115                 120                 125             
Val Leu Thr Pro Lys Glu Pro Gly Ser Ala Phe Leu Gln Leu Gly Val 
    130                 135                 140                 
Ser Leu Glu Gln Gln Leu Gln Val Leu Phe Lys Val Leu Glu Glu Tyr 
145                 150                 155                 160 
Asp Trp Ser Ala Phe Ala Val Ile Thr Ser Leu His Pro Gly His Ala 
                165                 170                 175     
Leu Phe Leu Glu Gly Val Arg Ala Val Ala Asp Ala Ser His Val Ser 
            180                 185                 190         
Trp Arg Leu Leu Asp Val Val Thr Leu Glu Leu Gly Pro Gly Gly Pro 
        195                 200                 205             
Arg Ala Arg Thr Gln Arg Leu Leu Arg Gln Leu Asp Ala Pro Val Phe 
    210                 215                 220                 
Val Ala Tyr Cys Ser Arg Glu Glu Ala Glu Val Leu Phe Ala Glu Ala 
225                 230                 235                 240 
Ala Gln Ala Gly Leu Val Gly Pro Gly His Val Trp Leu Val Pro Asn 
                245                 250                 255     
Leu Ala Leu Gly Ser Thr Asp Ala Pro Pro Ala Thr Phe Pro Val Gly 
            260                 265                 270         
Leu Ile Ser Val Val Thr Glu Ser Trp Arg Leu Ser Leu Arg Gln Lys 
        275                 280                 285             
Val Arg Asp Gly Val Ala Ile Leu Ala Leu Gly Ala His Ser Tyr Trp 
    290                 295                 300                 
Arg Gln His Gly Thr Leu Pro Ala Pro Ala Gly Asp Cys Arg Val His 
305                 310                 315                 320 
Pro Gly Pro Val Ser Pro Ala Arg Glu Ala Phe Tyr Arg His Leu Leu 
                325                 330                 335     
Asn Val Thr Trp Glu Gly Arg Asp Phe Ser Phe Ser Pro Gly Gly Tyr 
            340                 345                 350         
Leu Val Gln Pro Thr Met Val Val Ile Ala Leu Asn Arg His Arg Leu 
        355                 360                 365             
Trp Glu Met Val Gly Arg Trp Glu His Gly Val Leu Tyr Met Lys Tyr 
    370                 375                 380                 
Pro Val Trp Pro Arg Tyr Ser Ala Ser Leu Gln Pro Val Val Asp Ser 
385                 390                 395                 400 
Arg His Leu Thr Val Gly Ser Ser Thr Met Val Arg Ser Ser Lys Pro 
                405                 410                 415     
Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe 
            420                 425                 430         
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        435                 440                 445             
Thr Cys Val Val Val Asp Val Ser Gln Asp Asp Pro Glu Val Gln Phe 
    450                 455                 460                 
Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu 
465                 470                 475                 480 
Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro 
                485                 490                 495     
Ile Ala His Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val 
            500                 505                 510         
His Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        515                 520                 525             
Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg 
    530                 535                 540                 
Glu Glu Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly 
545                 550                 555                 560 
Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala 
                565                 570                 575     
Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser 
            580                 585                 590         
Tyr Phe Leu Tyr Ser Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg 
        595                 600                 605             
Gly Asp Val Phe Thr Cys Ser Val Met His Glu Ala Leu His Asn His 
    610                 615                 620                 
Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys 
625                 630                 635     

<210> 99
<211> 405
<212> PRT
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN2C (including signal sequence)

<400> 99
Met Gly Gly Ala Leu Gly Pro Ala Leu Leu Leu Thr Ser Leu Phe Gly 
1               5                   10                  15      
Ala Trp Ala Gly Leu Gly Pro Gly Gln Gly Glu Gln Gly Met Thr Val 
            20                  25                  30          
Ala Val Val Phe Ser Ser Ser Gly Pro Pro Gln Ala Gln Phe Arg Ala 
        35                  40                  45              
Arg Leu Thr Pro Gln Ser Phe Leu Asp Leu Pro Leu Glu Ile Gln Pro 
    50                  55                  60                  
Leu Thr Val Gly Val Asn Thr Thr Asn Pro Ser Ser Leu Leu Thr Gln 
65                  70                  75                  80  
Ile Cys Gly Leu Leu Gly Ala Ala His Val His Gly Ile Val Phe Glu 
                85                  90                  95      
Asp Asn Val Asp Thr Glu Ala Val Ala Gln Ile Leu Asp Phe Ile Ser 
            100                 105                 110         
Ser Gln Thr His Val Pro Ile Leu Ser Ile Ser Gly Gly Ser Ala Val 
        115                 120                 125             
Val Leu Thr Pro Lys Glu Pro Gly Ser Ala Phe Leu Gln Leu Gly Val 
    130                 135                 140                 
Ser Leu Glu Gln Gln Leu Gln Val Leu Phe Lys Val Leu Glu Glu Tyr 
145                 150                 155                 160 
Asp Trp Ser Ala Phe Ala Val Ile Thr Ser Leu His Pro Gly His Ala 
                165                 170                 175     
Leu Phe Leu Glu Gly Val Arg Ala Val Ala Asp Ala Ser His Val Ser 
            180                 185                 190         
Trp Arg Leu Leu Asp Val Val Thr Leu Glu Leu Gly Pro Gly Gly Pro 
        195                 200                 205             
Arg Ala Arg Thr Gln Arg Leu Leu Arg Gln Leu Asp Ala Pro Val Phe 
    210                 215                 220                 
Val Ala Tyr Cys Ser Arg Glu Glu Ala Glu Val Leu Phe Ala Glu Ala 
225                 230                 235                 240 
Ala Gln Ala Gly Leu Val Gly Pro Gly His Val Trp Leu Val Pro Asn 
                245                 250                 255     
Leu Ala Leu Gly Ser Thr Asp Ala Pro Pro Ala Thr Phe Pro Val Gly 
            260                 265                 270         
Leu Ile Ser Val Val Thr Glu Ser Trp Arg Leu Ser Leu Arg Gln Lys 
        275                 280                 285             
Val Arg Asp Gly Val Ala Ile Leu Ala Leu Gly Ala His Ser Tyr Trp 
    290                 295                 300                 
Arg Gln His Gly Thr Leu Pro Ala Pro Ala Gly Asp Cys Arg Val His 
305                 310                 315                 320 
Pro Gly Pro Val Ser Pro Ala Arg Glu Ala Phe Tyr Arg His Leu Leu 
                325                 330                 335     
Asn Val Thr Trp Glu Gly Arg Asp Phe Ser Phe Ser Pro Gly Gly Tyr 
            340                 345                 350         
Leu Val Gln Pro Thr Met Val Val Ile Ala Leu Asn Arg His Arg Leu 
        355                 360                 365             
Trp Glu Met Val Gly Arg Trp Glu His Gly Val Leu Tyr Met Lys Tyr 
    370                 375                 380                 
Pro Val Trp Pro Arg Tyr Ser Ala Ser Leu Gln Pro Val Val Asp Ser 
385                 390                 395                 400 
Arg His Leu Thr Val 
                405 

<210> 100
<211> 1911
<212> DNA
<213> Artificial Sequence


<220> 
<223> DNA seq of fusion protein #9 N2C-ATD-Fc

<400> 100
atgggtggcg cacttggccc tgctttgctg ctcactagcc tgtttggagc atgggctggt      60

cttgggccag gtcaaggcga gcaagggatg accgtggccg tggtgttctc ctcaagtgga     120

ccacctcagg cacagttccg tgccagactg acaccgcaga gcttcctgga tctcccactg     180

gagatacagc ctctcactgt gggcgtgaac accaccaatc cctcatccct gctgacacag     240

atctgcggac ttctgggtgc agcccatgtc cacgggatcg tgttcgagga caacgtggac     300

acagaagccg tagcccagat tctggacttc atcagctcac agacccacgt tcccattctg     360

agcattagtg gcgggagcgc tgtagtgctc actcccaaag agccggggtc tgcatttctg     420

cagctcggag taagccttga gcagcagctc caggtcttgt tcaaggtgct ggaagagtac     480

gactggtctg cgtttgccgt catcacctct ctgcatcctg gccatgctct gtttctggaa     540

ggcgttaggg ctgtcgccga tgcgtcccac gtcagttggc ggttgctgga tgtggtcacg     600

ttggagcttg gacctggagg ccccagggcc agaacacagc gactgctgcg ccaactggat     660

gctcccgtgt ttgtggccta ttgttcccgc gaggaggccg aggtgctctt cgccgaggcg     720

gcgcaggccg gtctggtggg gcccggccac gtgtggctgg tgcccaacct ggcgctgggc     780

agcaccgatg cgccccccgc caccttcccc gtgggcctca tcagcgtcgt caccgagagc     840

tggcgcctca gcctgcgcca gaaggtgcgc gacggcgtgg ccattctggc cctgggcgcc     900

cacagctact ggcgccagca tggaaccctg ccagccccgg ccggggactg ccgtgttcac     960

cctgggcccg tcagccctgc ccgggaggcc ttctacaggc acctactgaa tgtcacctgg    1020

gagggccgag acttctcctt cagccctggt gggtacctgg tccagcccac catggtggtg    1080

atcgccctca accggcaccg cctctgggag atggtggggc gctgggagca tggcgtccta    1140

tacatgaagt accccgtgtg gcctcgctac agtgcctctc tgcagcctgt ggtggacagt    1200

cggcacctga cggtgggctc gagcaccatg gttagatcta gcaagcccac gtgcccaccc    1260

cctgaactcc tggggggacc gtctgtcttc atcttccccc caaaacccaa ggacaccctc    1320

atgatctcac gcacccccga ggtcacatgc gtggtggtgg acgtgagcca ggatgacccc    1380

gaggtgcagt tcacatggta cataaacaac gagcaggtgc gcaccgcccg gccgccgcta    1440

cgggagcagc agttcaacag cacgatccgc gtggtcagca ccctccccat cgcgcaccag    1500

gactggctga ggggcaagga gttcaagtgc aaagtccaca acaaggcact cccggccccc    1560

atcgagaaaa ccatctccaa agccagaggg cagcccctgg agccgaaggt ctacaccatg    1620

ggccctcccc gggaggagct gagcagcagg tcggtcagcc tgacctgcat gatcaacggc    1680

ttctaccctt ccgacatctc ggtggagtgg gagaagaacg ggaaggcaga ggacaactac    1740

aagaccacgc cggccgtgct ggacagcgac ggctcctact tcctctacag caagctctca    1800

gtgcccacga gtgagtggca gcggggcgac gtcttcacct gctccgtgat gcacgaggcc    1860

ttgcacaacc actacacgca gaagtccatc tcccgctctc cgggtaaatg a             1911


<210> 101
<211> 1215
<212> DNA
<213> Homo sapiens


<220> 
<223> Amino terminal domain of GluN2C (including signal sequence)

<400> 101
atgggtggcg cacttggccc tgctttgctg ctcactagcc tgtttggagc atgggctggt      60

cttgggccag gtcaaggcga gcaagggatg accgtggccg tggtgttctc ctcaagtgga     120

ccacctcagg cacagttccg tgccagactg acaccgcaga gcttcctgga tctcccactg     180

gagatacagc ctctcactgt gggcgtgaac accaccaatc cctcatccct gctgacacag     240

atctgcggac ttctgggtgc agcccatgtc cacgggatcg tgttcgagga caacgtggac     300

acagaagccg tagcccagat tctggacttc atcagctcac agacccacgt tcccattctg     360

agcattagtg gcgggagcgc tgtagtgctc actcccaaag agccggggtc tgcatttctg     420

cagctcggag taagccttga gcagcagctc caggtcttgt tcaaggtgct ggaagagtac     480

gactggtctg cgtttgccgt catcacctct ctgcatcctg gccatgctct gtttctggaa     540

ggcgttaggg ctgtcgccga tgcgtcccac gtcagttggc ggttgctgga tgtggtcacg     600

ttggagcttg gacctggagg ccccagggcc agaacacagc gactgctgcg ccaactggat     660

gctcccgtgt ttgtggccta ttgttcccgc gaggaggccg aggtgctctt cgccgaggcg     720

gcgcaggccg gtctggtggg gcccggccac gtgtggctgg tgcccaacct ggcgctgggc     780

agcaccgatg cgccccccgc caccttcccc gtgggcctca tcagcgtcgt caccgagagc     840

tggcgcctca gcctgcgcca gaaggtgcgc gacggcgtgg ccattctggc cctgggcgcc     900

cacagctact ggcgccagca tggaaccctg ccagccccgg ccggggactg ccgtgttcac     960

cctgggcccg tcagccctgc ccgggaggcc ttctacaggc acctactgaa tgtcacctgg    1020

gagggccgag acttctcctt cagccctggt gggtacctgg tccagcccac catggtggtg    1080

atcgccctca accggcaccg cctctgggag atggtggggc gctgggagca tggcgtccta    1140

tacatgaagt accccgtgtg gcctcgctac agtgcctctc tgcagcctgt ggtggacagt    1200

cggcacctga cggtg                                                     1215


