                         SEQUENCE LISTING

<110>  Ͼ˹Ƽ޹˾
 
<120>  CD47/CTLA-4˫쿹弰ƱӦ

<130>  1

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  źĵDNA

<400>  1
atgggctggt cctgcatcat cctgttcctg gtggctaccg ccaccggcgt gcactcc          57


<210>  2
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  źĵİ

<400>  2

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  3
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H0DNA

<400>  3
gaggtgcagc tggtgcagtc cggagctgag gtgaagaagc caggatccag cgtgaaggtg       60

agctgcaagg ctagcggcta ctctttcacc caccattgga tccactgggt gaggcaggct      120

cctggacagg gactggagtg gatgggcatg atcgacgctt ccgatagcga gacaagactg      180

tctcagaagt ttaaggaccg cgtgaccatc acagccgata agtctacctc cacagcttac      240

atggagctgt cttccctgag atccgaggac accgccgtgt actattgtgc taggctgggc      300

cggtactatt tcgattattg gggccagggc accacagtga cagtgagctc tgccagcaca      360

aagggccctt ccgtgttccc actggctccc tgctccagaa gcacatctga gtccaccgcc      420

gctctgggct gtctggtgaa ggactacttc cctgagccag tgaccgtgtc ctggaacagc      480

ggcgccctga catctggcgt gcacaccttt ccagctgtgc tgcagtccag cggcctgtac      540

tccctgtctt ccgtggtgac agtgcccagc tcttccctgg gcaccaagac atatacctgc      600

aacgtggacc ataagccttc caataccaag gtggataaga gggtggagag caagtacgga      660

ccaccttgcc caccatgtcc agctcctgag tttgagggag gaccatccgt gttcctgttt      720

cctccaaagc ctaaggacac cctgatgatc agccggacac ctgaggtgac ctgcgtggtg      780

gtggacgtgt ctcaggagga tccagaggtg cagttcaact ggtacgtgga tggcgtggag      840

gtgcacaatg ctaagaccaa gccaagagag gagcagttta attccacata ccgcgtggtg      900

agcgtgctga ccgtgctgca tcaggattgg ctgaacggca aggagtataa gtgcaaggtg      960

tccaataagg gcctgcccag ctctatcgag aagacaatca gcaaggctaa gggacagcct     1020

agggagccac aggtgtacac cctgccccct tctcaggagg agatgacaaa gaaccaggtg     1080

tccctgacct gtctggtgaa gggcttctat ccaagcgaca tcgctgtgga gtgggagtct     1140

aatggccagc ccgagaacaa ttacaagacc acaccacccg tgctggactc tgatggctcc     1200

ttctttctgt attctaggct gacagtggat aagtcccggt ggcaggaggg caacgtgttt     1260

agctgctctg tgatgcacga ggccctgcac aatcattata cccagaagtc cctgagcctg     1320

tctctgggca ag                                                         1332


<210>  4
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H0İ

<400>  4

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr His His 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Asp Ala Ser Asp Ser Glu Thr Arg Leu Ser Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 


<210>  5
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L0DNA

<400>  5
gagatcgtgc tgacccagtc tccagccaca ctgtctctgt ccccaggaga gagggccacc       60

ctgagctgcc gggcttctga gaacgtgggc acatacatct cctggtatca gcagaagcca      120

ggacaggctc ctaggctgct gatctacggc gctagcaata gatataccgg catccctgct      180

cgcttcagcg gatctggatc cggcacagac tttaccctga caatctccag cctggagcca      240

gaggatttcg ccgtgtacta ttgtggcgag tcctacggcc acctgtatac ctttggcggc      300

ggcacaaagg tggagatcaa gcgaacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  6
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L0İ

<400>  6

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          


Ile Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gly Glu Ser Tyr Gly His Leu Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  7
<211>  1767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H1DNA

<400>  7
gaggtgcagc tggtgcagtc cggagctgag gtgaagaagc caggatccag cgtgaaggtg       60

agctgcaagg ctagcggcta ctctttcacc caccattgga tccactgggt gaggcaggct      120

cctggacagg gactggagtg gatgggcatg atcgacgctt ccgatagcga gacaagactg      180

tctcagaagt ttaaggaccg cgtgaccatc acagccgata agtctacctc cacagcttac      240

atggagctgt cttccctgag atccgaggac accgccgtgt actattgtgc taggctgggc      300

cggtactatt tcgattattg gggccagggc accacagtga cagtgagctc tgccagcaca      360

aagggccctt ccgtgttccc actggctccc tgctccagaa gcacatctga gtccaccgcc      420

gctctgggct gtctggtgaa ggactacttc cctgagccag tgaccgtgtc ctggaacagc      480

ggcgccctga catctggcgt gcacaccttt ccagctgtgc tgcagtccag cggcctgtac      540

tccctgtctt ccgtggtgac agtgcccagc tcttccctgg gcaccaagac atatacctgc      600

aacgtggacc ataagccttc caataccaag gtggataaga gggtggagag caagtacgga      660

ccaccttgcc caccatgtcc agctcctgag tttgagggag gaccatccgt gttcctgttt      720

cctccaaagc ctaaggacac cctgatgatc agccggacac ctgaggtgac ctgcgtggtg      780

gtggacgtgt ctcaggagga tccagaggtg cagttcaact ggtacgtgga tggcgtggag      840

gtgcacaatg ctaagaccaa gccaagagag gagcagttta attccacata ccgcgtggtg      900

agcgtgctga ccgtgctgca tcaggattgg ctgaacggca aggagtataa gtgcaaggtg      960

tccaataagg gcctgcccag ctctatcgag aagacaatca gcaaggctaa gggacagcct     1020

agggagccac aggtgtacac cctgccccct tctcaggagg agatgacaaa gaaccaggtg     1080

tccctgacct gtctggtgaa gggcttctat ccaagcgaca tcgctgtgga gtgggagtct     1140

aatggccagc ccgagaacaa ttacaagacc acaccacccg tgctggactc tgatggctcc     1200

ttctttctgt attctaggct gacagtggat aagtcccggt ggcaggaggg caacgtgttt     1260

agctgctctg tgatgcacga ggccctgcac aatcattata cccagaagtc cctgagcctg     1320

tctctgggca aggaacctaa gtctagcgac aaaactcata ccagcccccc tagtccagag     1380

gtgcagctgg tggaatctgg gggaggactg gtgcagcctg ggggaagcct gagactgagt     1440

tgtgccgcaa gcggatacac ttacagcagg cactgcctgg gatggttccg acaggcacca     1500

ggcaagggac gagaggccgt gtctaccatc gacagtgatg ggagcacatc ctacgctgac     1560

tcagtcaagg gacggtttac tatcagcaga gataacgcaa agaacaccct gtatctgcag     1620

atgaactccc tgagaccaga agacacagcc gtgtactatt gcgctatcgg acccaaccct     1680

cggtactgtt ctggcgcccc caatacccgg ggagccgaac attactttgg gtattgggga     1740

cagggcacac tggtgaccgt gagcagc                                         1767


<210>  8
<211>  589
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H1İ

<400>  8

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr His His 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Asp Ala Ser Asp Ser Glu Thr Arg Leu Ser Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Glu Pro Lys Ser 
        435                 440                 445             


Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Glu Val Gln Leu Val 
    450                 455                 460                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
465                 470                 475                 480 


Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Arg His Cys Leu Gly Trp Phe 
                485                 490                 495     


Arg Gln Ala Pro Gly Lys Gly Arg Glu Ala Val Ser Thr Ile Asp Ser 
            500                 505                 510         


Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        515                 520                 525             


Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
    530                 535                 540                 


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ile Gly Pro Asn Pro 
545                 550                 555                 560 


Arg Tyr Cys Ser Gly Ala Pro Asn Thr Arg Gly Ala Glu His Tyr Phe 
                565                 570                 575     


Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            580                 585                 


<210>  9
<211>  1767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H2DNA

<400>  9
gaggtgcagc tggtggaatc tgggggagga ctggtgcagc ctgggggaag cctgagactg       60

agttgtgccg caagcggata cacttacagc aggcactgcc tgggatggtt ccgacaggca      120

ccaggcaagg gacgagaggc cgtgtctacc atcgacagtg atgggagcac atcctacgct      180

gactcagtca agggacggtt tactatcagc agagataacg caaagaacac cctgtatctg      240

cagatgaact ccctgagacc agaagacaca gccgtgtact attgcgctat cggacccaac      300

cctcggtact gttctggcgc ccccaatacc cggggagccg aacattactt tgggtattgg      360

ggacagggca cactggtgac cgtgagcagc gaacctaagt ctagcgacaa aactcatacc      420

agccccccta gtccagaggt gcagctggtg cagtccggag ctgaggtgaa gaagccagga      480

tccagcgtga aggtgagctg caaggctagc ggctactctt tcacccacca ttggatccac      540

tgggtgaggc aggctcctgg acagggactg gagtggatgg gcatgatcga cgcttccgat      600

agcgagacaa gactgtctca gaagtttaag gaccgcgtga ccatcacagc cgataagtct      660

acctccacag cttacatgga gctgtcttcc ctgagatccg aggacaccgc cgtgtactat      720

tgtgctaggc tgggccggta ctatttcgat tattggggcc agggcaccac agtgacagtg      780

agctctgcca gcacaaaggg cccttccgtg ttcccactgg ctccctgctc cagaagcaca      840

tctgagtcca ccgccgctct gggctgtctg gtgaaggact acttccctga gccagtgacc      900

gtgtcctgga acagcggcgc cctgacatct ggcgtgcaca cctttccagc tgtgctgcag      960

tccagcggcc tgtactccct gtcttccgtg gtgacagtgc ccagctcttc cctgggcacc     1020

aagacatata cctgcaacgt ggaccataag ccttccaata ccaaggtgga taagagggtg     1080

gagagcaagt acggaccacc ttgcccacca tgtccagctc ctgagtttga gggaggacca     1140

tccgtgttcc tgtttcctcc aaagcctaag gacaccctga tgatcagccg gacacctgag     1200

gtgacctgcg tggtggtgga cgtgtctcag gaggatccag aggtgcagtt caactggtac     1260

gtggatggcg tggaggtgca caatgctaag accaagccaa gagaggagca gtttaattcc     1320

acataccgcg tggtgagcgt gctgaccgtg ctgcatcagg attggctgaa cggcaaggag     1380

tataagtgca aggtgtccaa taagggcctg cccagctcta tcgagaagac aatcagcaag     1440

gctaagggac agcctaggga gccacaggtg tacaccctgc ccccttctca ggaggagatg     1500

acaaagaacc aggtgtccct gacctgtctg gtgaagggct tctatccaag cgacatcgct     1560

gtggagtggg agtctaatgg ccagcccgag aacaattaca agaccacacc acccgtgctg     1620

gactctgatg gctccttctt tctgtattct aggctgacag tggataagtc ccggtggcag     1680

gagggcaacg tgtttagctg ctctgtgatg cacgaggccc tgcacaatca ttatacccag     1740

aagtccctga gcctgtctct gggcaag                                         1767


<210>  10
<211>  589
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H2İ

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Arg His 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Ala Val 
        35                  40                  45              


Ser Thr Ile Asp Ser Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ile Gly Pro Asn Pro Arg Tyr Cys Ser Gly Ala Pro Asn Thr Arg Gly 
            100                 105                 110         


Ala Glu His Tyr Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser 
    130                 135                 140                 


Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
145                 150                 155                 160 


Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr His 
                165                 170                 175     


His Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
            180                 185                 190         


Met Gly Met Ile Asp Ala Ser Asp Ser Glu Thr Arg Leu Ser Gln Lys 
        195                 200                 205             


Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala 
    210                 215                 220                 


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Leu Gly Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
            260                 265                 270         


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
        275                 280                 285             


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
    290                 295                 300                 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
305                 310                 315                 320 


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
                325                 330                 335     


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
            340                 345                 350         


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
        355                 360                 365             


Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 
    370                 375                 380                 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
385                 390                 395                 400 


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
                405                 410                 415     


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
            420                 425                 430         


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
        435                 440                 445             


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
    450                 455                 460                 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
465                 470                 475                 480 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
                485                 490                 495     


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
            500                 505                 510         


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
        515                 520                 525             


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
    530                 535                 540                 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
545                 550                 555                 560 


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                565                 570                 575     


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            580                 585                 


<210>  11
<211>  1767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H3DNA

<400>  11
gaggtgcagc tggtgcagtc cggagctgag gtgaagaagc caggatccag cgtgaaggtg       60

agctgcaagg ctagcggcta ctctttcacc caccattgga tccactgggt gaggcaggct      120

cctggacagg gactggagtg gatgggcatg atcgacgctt ccgatagcga gacaagactg      180

tctcagaagt ttaaggaccg cgtgaccatc acagccgata agtctacctc cacagcttac      240

atggagctgt cttccctgag atccgaggac accgccgtgt actattgtgc taggctgggc      300

cggtactatt tcgattattg gggccagggc accacagtga cagtgagctc tgccagcaca      360

aagggccctt ccgtgttccc actggctccc tgctccagaa gcacatctga gtccaccgcc      420

gctctgggct gtctggtgaa ggactacttc cctgagccag tgaccgtgtc ctggaacagc      480

ggcgccctga catctggcgt gcacaccttt ccagctgtgc tgcagtccag cggcctgtac      540

tccctgtctt ccgtggtgac agtgcccagc tcttccctgg gcaccaagac atatacctgc      600

aacgtggacc ataagccttc caataccaag gtggataaga gggtggagag caagtacgga      660

ccaccttgcc caccatgtcc agctcctgag tttgagggag gaccatccgt gttcctgttt      720

cctccaaagc ctaaggacac cctgatgatc agccggacac ctgaggtgac ctgcgtggtg      780

gtggacgtgt ctcaggagga tccagaggtg cagttcaact ggtacgtgga tggcgtggag      840

gtgcacaatg ctaagaccaa gccaagagag gagcagttta attccacata ccgcgtggtg      900

agcgtgctga ccgtgctgca tcaggattgg ctgaacggca aggagtataa gtgcaaggtg      960

tccaataagg gcctgcccag ctctatcgag aagacaatca gcaaggctaa gggacagcct     1020

agggagccac aggtgtacac cctgccccct tctcaggagg agatgacaaa gaaccaggtg     1080

tccctgacct gtctggtgaa gggcttctat ccaagcgaca tcgctgtgga gtgggagtct     1140

aatggccagc ccgagaacaa ttacaagacc acaccacccg tgctggactc tgatggctcc     1200

ttctttctgt attctaggct gacagtggat aagtcccggt ggcaggaggg caacgtgttt     1260

agctgctctg tgatgcacga ggccctgcac aatcattata cccagaagtc cctgagcctg     1320

tctctgggca agggtggagg cggtagtgga ggcggtggtt caggcggagg cggatctgag     1380

gtgcagctgg tggaatctgg gggaggactg gtgcagcctg ggggaagcct gagactgagt     1440

tgtgccgcaa gcggatacac ttacagcagg cactgcctgg gatggttccg acaggcacca     1500

ggcaagggac gagaggccgt gtctaccatc gacagtgatg ggagcacatc ctacgctgac     1560

tcagtcaagg gacggtttac tatcagcaga gataacgcaa agaacaccct gtatctgcag     1620

atgaactccc tgagaccaga agacacagcc gtgtactatt gcgctatcgg acccaaccct     1680

cggtactgtt ctggcgcccc caatacccgg ggagccgaac attactttgg gtattgggga     1740

cagggcacac tggtgaccgt gagcagc                                         1767


<210>  12
<211>  589
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3İ

<400>  12

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr His His 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Met Ile Asp Ala Ser Asp Ser Glu Thr Arg Leu Ser Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
    450                 455                 460                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
465                 470                 475                 480 


Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Arg His Cys Leu Gly Trp Phe 
                485                 490                 495     


Arg Gln Ala Pro Gly Lys Gly Arg Glu Ala Val Ser Thr Ile Asp Ser 
            500                 505                 510         


Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        515                 520                 525             


Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
    530                 535                 540                 


Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ile Gly Pro Asn Pro 
545                 550                 555                 560 


Arg Tyr Cys Ser Gly Ala Pro Asn Thr Arg Gly Ala Glu His Tyr Phe 
                565                 570                 575     


Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            580                 585                 


<210>  13
<211>  1767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H4DNA

<400>  13
gaggtgcagc tggtggaatc tgggggagga ctggtgcagc ctgggggaag cctgagactg       60

agttgtgccg caagcggata cacttacagc aggcactgcc tgggatggtt ccgacaggca      120

ccaggcaagg gacgagaggc cgtgtctacc atcgacagtg atgggagcac atcctacgct      180

gactcagtca agggacggtt tactatcagc agagataacg caaagaacac cctgtatctg      240

cagatgaact ccctgagacc agaagacaca gccgtgtact attgcgctat cggacccaac      300

cctcggtact gttctggcgc ccccaatacc cggggagccg aacattactt tgggtattgg      360

ggacagggca cactggtgac cgtgagcagc ggtggaggcg gtagtggagg cggtggttca      420

ggcggaggcg gatctgaggt gcagctggtg cagtccggag ctgaggtgaa gaagccagga      480

tccagcgtga aggtgagctg caaggctagc ggctactctt tcacccacca ttggatccac      540

tgggtgaggc aggctcctgg acagggactg gagtggatgg gcatgatcga cgcttccgat      600

agcgagacaa gactgtctca gaagtttaag gaccgcgtga ccatcacagc cgataagtct      660

acctccacag cttacatgga gctgtcttcc ctgagatccg aggacaccgc cgtgtactat      720

tgtgctaggc tgggccggta ctatttcgat tattggggcc agggcaccac agtgacagtg      780

agctctgcca gcacaaaggg cccttccgtg ttcccactgg ctccctgctc cagaagcaca      840

tctgagtcca ccgccgctct gggctgtctg gtgaaggact acttccctga gccagtgacc      900

gtgtcctgga acagcggcgc cctgacatct ggcgtgcaca cctttccagc tgtgctgcag      960

tccagcggcc tgtactccct gtcttccgtg gtgacagtgc ccagctcttc cctgggcacc     1020

aagacatata cctgcaacgt ggaccataag ccttccaata ccaaggtgga taagagggtg     1080

gagagcaagt acggaccacc ttgcccacca tgtccagctc ctgagtttga gggaggacca     1140

tccgtgttcc tgtttcctcc aaagcctaag gacaccctga tgatcagccg gacacctgag     1200

gtgacctgcg tggtggtgga cgtgtctcag gaggatccag aggtgcagtt caactggtac     1260

gtggatggcg tggaggtgca caatgctaag accaagccaa gagaggagca gtttaattcc     1320

acataccgcg tggtgagcgt gctgaccgtg ctgcatcagg attggctgaa cggcaaggag     1380

tataagtgca aggtgtccaa taagggcctg cccagctcta tcgagaagac aatcagcaag     1440

gctaagggac agcctaggga gccacaggtg tacaccctgc ccccttctca ggaggagatg     1500

acaaagaacc aggtgtccct gacctgtctg gtgaagggct tctatccaag cgacatcgct     1560

gtggagtggg agtctaatgg ccagcccgag aacaattaca agaccacacc acccgtgctg     1620

gactctgatg gctccttctt tctgtattct aggctgacag tggataagtc ccggtggcag     1680

gagggcaacg tgtttagctg ctctgtgatg cacgaggccc tgcacaatca ttatacccag     1740

aagtccctga gcctgtctct gggcaag                                         1767


<210>  14
<211>  589
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H4İ

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Arg His 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Ala Val 
        35                  40                  45              


Ser Thr Ile Asp Ser Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ile Gly Pro Asn Pro Arg Tyr Cys Ser Gly Ala Pro Asn Thr Arg Gly 
            100                 105                 110         


Ala Glu His Tyr Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
145                 150                 155                 160 


Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr His 
                165                 170                 175     


His Trp Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
            180                 185                 190         


Met Gly Met Ile Asp Ala Ser Asp Ser Glu Thr Arg Leu Ser Gln Lys 
        195                 200                 205             


Phe Lys Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala 
    210                 215                 220                 


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Ala Arg Leu Gly Arg Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
            260                 265                 270         


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
        275                 280                 285             


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
    290                 295                 300                 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
305                 310                 315                 320 


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
                325                 330                 335     


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
            340                 345                 350         


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
        355                 360                 365             


Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 
    370                 375                 380                 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
385                 390                 395                 400 


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
                405                 410                 415     


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
            420                 425                 430         


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
        435                 440                 445             


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
    450                 455                 460                 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
465                 470                 475                 480 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
                485                 490                 495     


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
            500                 505                 510         


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
        515                 520                 525             


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
    530                 535                 540                 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
545                 550                 555                 560 


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                565                 570                 575     


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            580                 585                 


<210>  15
<211>  1077
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L1DNA

<400>  15
gaggtgcagc tggtggaatc tgggggagga ctggtgcagc ctgggggaag cctgagactg       60

agttgtgccg caagcggata cacttacagc aggcactgcc tgggatggtt ccgacaggca      120

ccaggcaagg gacgagaggc cgtgtctacc atcgacagtg atgggagcac atcctacgct      180

gactcagtca agggacggtt tactatcagc agagataacg caaagaacac cctgtatctg      240

cagatgaact ccctgagacc agaagacaca gccgtgtact attgcgctat cggacccaac      300

cctcggtact gttctggcgc ccccaatacc cggggagccg aacattactt tgggtattgg      360

ggacagggca cactggtgac cgtgagcagc ggtggaggcg gtagtggagg cggtggttca      420

ggcggaggcg gatctgagat cgtgctgacc cagtctccag ccacactgtc tctgtcccca      480

ggagagaggg ccaccctgag ctgccgggct tctgagaacg tgggcacata catctcctgg      540

tatcagcaga agccaggaca ggctcctagg ctgctgatct acggcgctag caatagatat      600

accggcatcc ctgctcgctt cagcggatct ggatccggca cagactttac cctgacaatc      660

tccagcctgg agccagagga tttcgccgtg tactattgtg gcgagtccta cggccacctg      720

tatacctttg gcggcggcac aaaggtggag atcaagcgaa cggtggctgc accatctgtc      780

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      840

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      900

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      960

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa     1020

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt        1077


<210>  16
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L1İ

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Arg His 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Ala Val 
        35                  40                  45              


Ser Thr Ile Asp Ser Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ile Gly Pro Asn Pro Arg Tyr Cys Ser Gly Ala Pro Asn Thr Arg Gly 
            100                 105                 110         


Ala Glu His Tyr Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
145                 150                 155                 160 


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Asn Val Gly Thr 
                165                 170                 175     


Tyr Ile Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
            180                 185                 190         


Ile Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Ile Pro Ala Arg Phe Ser 
        195                 200                 205             


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
    210                 215                 220                 


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gly Glu Ser Tyr Gly His Leu 
225                 230                 235                 240 


Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
                245                 250                 255     


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
            260                 265                 270         


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
        275                 280                 285             


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
    290                 295                 300                 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
305                 310                 315                 320 


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
                325                 330                 335     


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
            340                 345                 350         


Ser Phe Asn Arg Gly Glu Cys 
        355                 


<210>  17
<211>  1059
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  L2DNA

<400>  17
gaggtgcagc tggtggaatc tgggggagga ctggtgcagc ctgggggaag cctgagactg       60

agttgtgccg caagcggata cacttacagc aggcactgcc tgggatggtt ccgacaggca      120

ccaggcaagg gacgagaggc cgtgtctacc atcgacagtg atgggagcac atcctacgct      180

gactcagtca agggacggtt tactatcagc agagataacg caaagaacac cctgtatctg      240

cagatgaact ccctgagacc agaagacaca gccgtgtact attgcgctat cggacccaac      300

cctcggtact gttctggcgc ccccaatacc cggggagccg aacattactt tgggtattgg      360

ggacagggca cactggtgac cgtgagcagc ggtggaggcg gtagtggagg cggttcagag      420

atcgtgctga cccagtctcc agccacactg tctctgtccc caggagagag ggccaccctg      480

agctgccggg cttctgagaa cgtgggcaca tacatctcct ggtatcagca gaagccagga      540

caggctccta ggctgctgat ctacggcgct agcaatagat ataccggcat ccctgctcgc      600

ttcagcggat ctggatccgg cacagacttt accctgacaa tctccagcct ggagccagag      660

gatttcgccg tgtactattg tggcgagtcc tacggccacc tgtatacctt tggcggcggc      720

acaaaggtgg agatcaagcg aacggtggct gcaccatctg tcttcatctt cccgccatct      780

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      840

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      900

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      960

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg     1020

agctcgcccg tcacaaagag cttcaacagg ggagagtgt                            1059


<210>  18
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L2İ

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Arg His 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Ala Val 
        35                  40                  45              


Ser Thr Ile Asp Ser Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ile Gly Pro Asn Pro Arg Tyr Cys Ser Gly Ala Pro Asn Thr Arg Gly 
            100                 105                 110         


Ala Glu His Tyr Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Ile Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
145                 150                 155                 160 


Ser Cys Arg Ala Ser Glu Asn Val Gly Thr Tyr Ile Ser Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn 
            180                 185                 190         


Arg Tyr Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Gly Glu Ser Tyr Gly His Leu Tyr Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
                245                 250                 255     


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
            260                 265                 270         


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
        275                 280                 285             


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
    290                 295                 300                 


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
305                 310                 315                 320 


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
                325                 330                 335     


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
            340                 345                 350         


Cys 
    


<210>  19
<211>  1077
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H5DNA

<400>  19
gaggtgcagc tggtggaatc tgggggagga ctggtgcagc ctgggggaag cctgagactg       60

agttgtgccg caagcggata cacttacagc aggcactgcc tgggatggtt ccgacaggca      120

ccaggcaagg gacgagaggc cgtgtctacc atcgacagtg atgggagcac atcctacgct      180

gactcagtca agggacggtt tactatcagc agagataacg caaagaacac cctgtatctg      240

cagatgaact ccctgagacc agaagacaca gccgtgtact attgcgctat cggacccaac      300

cctcggtact gttctggcgc ccccaatacc cggggagccg aacattactt tgggtattgg      360

ggacagggca cactggtgac cgtgagcagc gagagcaagt acggaccacc ttgcccacca      420

tgtccagctc ctgagtttga gggaggacca tccgtgttcc tgtttcctcc aaagcctaag      480

gacaccctga tgatcagccg gacacctgag gtgacctgcg tggtggtgga cgtgtctcag      540

gaggatccag aggtgcagtt caactggtac gtggatggcg tggaggtgca caatgctaag      600

accaagccaa gagaggagca gtttaattcc acataccgcg tggtgagcgt gctgaccgtg      660

ctgcatcagg attggctgaa cggcaaggag tataagtgca aggtgtccaa taagggcctg      720

cccagctcta tcgagaagac aatcagcaag gctaagggac agcctaggga gccacaggtg      780

tacaccctgc ccccttctca ggaggagatg acaaagaacc aggtgtccct gacctgtctg      840

gtgaagggct tctatccaag cgacatcgct gtggagtggg agtctaatgg ccagcccgag      900

aacaattaca agaccacacc acccgtgctg gactctgatg gctccttctt tctgtattct      960

aggctgacag tggataagtc ccggtggcag gagggcaacg tgtttagctg ctctgtgatg     1020

cacgaggccc tgcacaatca ttatacccag aagtccctga gcctgtctct gggcaag        1077


<210>  20
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H5İ

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Arg His 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Ala Val 
        35                  40                  45              


Ser Thr Ile Asp Ser Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ile Gly Pro Asn Pro Arg Tyr Cys Ser Gly Ala Pro Asn Thr Arg Gly 
            100                 105                 110         


Ala Glu His Tyr Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
    130                 135                 140                 


Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
145                 150                 155                 160 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                165                 170                 175     


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
            180                 185                 190         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
        195                 200                 205             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    210                 215                 220                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
225                 230                 235                 240 


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                245                 250                 255     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
            260                 265                 270         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        275                 280                 285             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    290                 295                 300                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
305                 310                 315                 320 


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
                325                 330                 335     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            340                 345                 350         


Leu Ser Leu Ser Leu Gly Lys 
        355                 


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD47CDR1 

<400>  21

Gly Tyr Ser Phe Thr His His Trp Ile His 
1               5                   10  


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD47CDR2 

<400>  22

Met Ile Asp Ala Ser Asp Ser Glu Thr Arg Leu Ser Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD47CDR3 

<400>  23

Leu Gly Arg Tyr Tyr Phe Asp Tyr 
1               5               


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD47CDR1 

<400>  24

Arg Ala Ser Glu Asn Val Gly Thr Tyr Ile Ser 
1               5                   10      


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD47CDR2 

<400>  25

Gly Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD47CDR3 

<400>  26

Gly Glu Ser Tyr Gly His Leu Tyr Thr 
1               5                   


<210>  27
<211>  390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTLA-4DNA

<400>  27
gaggtgcagc tggtggaatc tgggggagga ctggtgcagc ctgggggaag cctgagactg       60

agttgtgccg caagcggata cacttacagc aggcactgcc tgggatggtt ccgacaggca      120

ccaggcaagg gacgagaggc cgtgtctacc atcgacagtg atgggagcac atcctacgct      180

gactcagtca agggacggtt tactatcagc agagataacg caaagaacac cctgtatctg      240

cagatgaact ccctgagacc agaagacaca gccgtgtact attgcgctat cggacccaac      300

cctcggtact gttctggcgc ccccaatacc cggggagccg aacattactt tgggtattgg      360

ggacagggca cactggtgac cgtgagcagc                                       390


<210>  28
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA-4就

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Tyr Ser Arg His 
            20                  25                  30          


Cys Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Ala Val 
        35                  40                  45              


Ser Thr Ile Asp Ser Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ile Gly Pro Asn Pro Arg Tyr Cys Ser Gly Ala Pro Asn Thr Arg Gly 
            100                 105                 110         


Ala Glu His Tyr Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA-4CDR1

<400>  29

Gly Tyr Thr Tyr Ser Arg His Cys Leu Gly 
1               5                   10  


<210>  30
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA-4CDR2

<400>  30

Thr Ile Asp Ser Asp Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  31
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA-4CDR3

<400>  31

Gly Pro Asn Pro Arg Tyr Cys Ser Gly Ala Pro Asn Thr Arg Gly Ala 
1               5                   10                  15      


Glu His Tyr Phe Gly Tyr 
            20          


<210>  32
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E-Linker ͷDNA

<400>  32
gaacctaagt ctagcgacaa aactcatacc agccccccta gtcca                       45


<210>  33
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E-Linkerͷ

<400>  33

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  34
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G15-LinkerͷDNA

<400>  34
ggtggaggcg gtagtggagg cggtggttca ggcggaggcg gatct                       45


<210>  35
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G15-Linker

<400>  35

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  36
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G9-LinkerͷDNA

<400>  36
ggtggaggcg gtagtggagg cggttca                                           27


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G9-Linker

<400>  37

Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   


<210>  38
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG4 Fc DNA

<400>  38
gagagcaagt acggaccacc ttgcccacca tgtccagctc ctgagtttga gggaggacca       60

tccgtgttcc tgtttcctcc aaagcctaag gacaccctga tgatcagccg gacacctgag      120

gtgacctgcg tggtggtgga cgtgtctcag gaggatccag aggtgcagtt caactggtac      180

gtggatggcg tggaggtgca caatgctaag accaagccaa gagaggagca gtttaattcc      240

acataccgcg tggtgagcgt gctgaccgtg ctgcatcagg attggctgaa cggcaaggag      300

tataagtgca aggtgtccaa taagggcctg cccagctcta tcgagaagac aatcagcaag      360

gctaagggac agcctaggga gccacaggtg tacaccctgc ccccttctca ggaggagatg      420

acaaagaacc aggtgtccct gacctgtctg gtgaagggct tctatccaag cgacatcgct      480

gtggagtggg agtctaatgg ccagcccgag aacaattaca agaccacacc acccgtgctg      540

gactctgatg gctccttctt tctgtattct aggctgacag tggataagtc ccggtggcag      600

gagggcaacg tgtttagctg ctctgtgatg cacgaggccc tgcacaatca ttatacccag      660

aagtccctga gcctgtctct gggcaag                                          687


<210>  39
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 Fc 

<400>  39

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


