                        б

<110>  ˻ݣҽҩ޹˾
<120> ETA弰TGF- TrapںϵʣԼҩӦ
<130>  2019
<160>  212  

<170>  PatentIn version 3.5

<210>  1
<211>  1868
<212>  DNA
<213>  

<400>  1
gaattcggga aaaagtgaag gtgtaaaagc agcacaagtg caataagaga tatttcctca       60

aatttgcctc aagatggaaa ccctttgcct cagggcatcc ttttggctgg cactggttgg      120

atgtgtaatc agtgataatc ctgagagata cagcacaaat ctaagcaatc atgtggatga      180

tttcaccact tttcgtggca cagagctcag cttcctggtt accactcatc aacccactaa      240

tttggtccta cccagcaatg gctcaatgca caactattgc ccacagcaga ctaaaattac      300

ttcagctttc aaatacatta acactgtgat atcttgtact attttcatcg tgggaatggt      360

ggggaatgca actctgctca ggatcattta ccagaacaaa tgtatgagga atggccccaa      420

cgcgctgata gccagtcttg cccttggaga ccttatctat gtggtcattg atctccctat      480

caatgtattt aagctgctgg ctgggcgctg gccttttgat cacaatgact ttggcgtatt      540

tctttgcaag ctgttcccct ttttgcagaa gtcctcggtg gggatcaccg tcctcaacct      600

ctgcgctctt agtgttgaca ggtacagagc agttgcctcc tggagtcgtg ttcagggaat      660

tgggattcct ttggtaactg ccattgaaat tgtctccatc tggatcctgt cctttatcct      720

ggccattcct gaagcgattg gcttcgtcat ggtacccttt gaatataggg gtgaacagca      780

taaaacctgt atgctcaatg ccacatcaaa attcatggag ttctaccaag atgtaaagga      840

ctggtggctc ttcgggttct atttctgtat gcccttggtg tgcactgcga tcttctacac      900

cctcatgact tgtgagatgt tgaacagaag gaatggcagc ttgagaattg ccctcagtga      960

acatcttaag cagcgtcgag aagtggcaaa aacagttttc tgcttggttg taatttttgc     1020

tctttgctgg ttccctcttc atttaagccg tatattgaag aaaactgtgt ataacgagat     1080

ggacaagaac cgatgtgaat tacttagttt cttactgctc atggattaca tcggtattaa     1140

cttggcaacc atgaattcat gtataaaccc catagctctg tattttgtga gcaagaaatt     1200

taaaaattgt ttccagtcat gcctctgctg ctgctgttac cagtccaaaa gtctgatgac     1260

ctcggtcccc atgaacggaa caagcatcca gtggaagaac cacgatcaaa acaaccacaa     1320

cacagaccgg agcagccata aggacagcat gaactgacca cccttagaag cactcctcgg     1380

tactcccata atcctctcgg agaaaaaaat cacaaggcaa ctgtgagtcc gggaatctct     1440

tctctgatcc ttcttcctta attcactccc acacccaaga agaaatgctt tccaaaaccg     1500

caagggtaga ctggtttatc cacccacaac atctacgaat cgtacttctt taattgatct     1560

aatttacata ttctgcgtgt tgtattcagc actaaaaaat ggtgggagct gggggagaat     1620

gaagactgtt aaatgaaacc agaaggatat ttactacttt tgcatgaaaa tagagctttc     1680

aagtacatgg ctagctttta tggcagttct ggtgaatgtt caatgggaac tggtcaccat     1740

gaaactttag agattaacga caagattttc tacttttttt aagtgatttt tttgtccttc     1800

agccaaacac aatatgggct caagtcactt ttatttgaaa tgtcatttgg tgccagtatc     1860

ccgaattc                                                              1868


<210>  2
<211>  427
<212>  PRT
<213>  

<400>  2

Met Glu Thr Leu Cys Leu Arg Ala Ser Phe Trp Leu Ala Leu Val Gly 
1               5                   10                  15      


Cys Val Ile Ser Asp Asn Pro Glu Arg Tyr Ser Thr Asn Leu Ser Asn 
            20                  25                  30          


His Val Asp Asp Phe Thr Thr Phe Arg Gly Thr Glu Leu Ser Phe Leu 
        35                  40                  45              


Val Thr Thr His Gln Pro Thr Asn Leu Val Leu Pro Ser Asn Gly Ser 
    50                  55                  60                  


Met His Asn Tyr Cys Pro Gln Gln Thr Lys Ile Thr Ser Ala Phe Lys 
65                  70                  75                  80  


Tyr Ile Asn Thr Val Ile Ser Cys Thr Ile Phe Ile Val Gly Met Val 
                85                  90                  95      


Gly Asn Ala Thr Leu Leu Arg Ile Ile Tyr Gln Asn Lys Cys Met Arg 
            100                 105                 110         


Asn Gly Pro Asn Ala Leu Ile Ala Ser Leu Ala Leu Gly Asp Leu Ile 
        115                 120                 125             


Tyr Val Val Ile Asp Leu Pro Ile Asn Val Phe Lys Leu Leu Ala Gly 
    130                 135                 140                 


Arg Trp Pro Phe Asp His Asn Asp Phe Gly Val Phe Leu Cys Lys Leu 
145                 150                 155                 160 


Phe Pro Phe Leu Gln Lys Ser Ser Val Gly Ile Thr Val Leu Asn Leu 
                165                 170                 175     


Cys Ala Leu Ser Val Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
            180                 185                 190         


Val Gln Gly Ile Gly Ile Pro Leu Val Thr Ala Ile Glu Ile Val Ser 
        195                 200                 205             


Ile Trp Ile Leu Ser Phe Ile Leu Ala Ile Pro Glu Ala Ile Gly Phe 
    210                 215                 220                 


Val Met Val Pro Phe Glu Tyr Arg Gly Glu Gln His Lys Thr Cys Met 
225                 230                 235                 240 


Leu Asn Ala Thr Ser Lys Phe Met Glu Phe Tyr Gln Asp Val Lys Asp 
                245                 250                 255     


Trp Trp Leu Phe Gly Phe Tyr Phe Cys Met Pro Leu Val Cys Thr Ala 
            260                 265                 270         


Ile Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Asn Arg Arg Asn Gly 
        275                 280                 285             


Ser Leu Arg Ile Ala Leu Ser Glu His Leu Lys Gln Arg Arg Glu Val 
    290                 295                 300                 


Ala Lys Thr Val Phe Cys Leu Val Val Ile Phe Ala Leu Cys Trp Phe 
305                 310                 315                 320 


Pro Leu His Leu Ser Arg Ile Leu Lys Lys Thr Val Tyr Asn Glu Met 
                325                 330                 335     


Asp Lys Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Leu Met Asp Tyr 
            340                 345                 350         


Ile Gly Ile Asn Leu Ala Thr Met Asn Ser Cys Ile Asn Pro Ile Ala 
        355                 360                 365             


Leu Tyr Phe Val Ser Lys Lys Phe Lys Asn Cys Phe Gln Ser Cys Leu 
    370                 375                 380                 


Cys Cys Cys Cys Tyr Gln Ser Lys Ser Leu Met Thr Ser Val Pro Met 
385                 390                 395                 400 


Asn Gly Thr Ser Ile Gln Trp Lys Asn His Asp Gln Asn Asn His Asn 
                405                 410                 415     


Thr Asp Arg Ser Ser His Lys Asp Ser Met Asn 
            420                 425         



<210>  3
<211>  2493
<212>  DNA
<213>  

<400>  3
cgggggtggc tgtgtcccag gatagctgga aggttaggac gctcttgcgg tcccagagtg       60

gagtggaagt tctggagctt tgggaggaga cggggaggac agactggagg cgtgttcctc      120

cggagttttc ttttccgtgc gagccctcgc gcgcgcgtac agtcatcccg ctggtctgac      180

gattgtggag aggaggtgga gaggcttcat ccatcccacc cggtcgtcgc ggggaattgg      240

ggtcccagcg agacctcccc cggagaagca gtgcccagga agttttctga agccggggta      300

gctgtgcagc cggagccgcc gccgcgccgg agcccgggac accggccacc ctccgcgcca      360

cccacccttg ccggctccgg cttcctctgg cccaggcgcc tcgcggaccc ggcagctgtc      420

tgcgcccgcc gagctccacg gtgaaaaaaa tagtgaaggt gtaaaagcag cacaagtgca      480

ataagagata tttcctcaaa tttgcctcaa gatggaaacc gtttgcctca gggcatcctt      540

ttggctggca ctggttggat gtgtaatcag tgataatgct gagagataca gcacaaatct      600

aagcaatcat gtggatgatt tcaccacttt tcatggcaca gagctcagcc tcctggttac      660

cactcatcaa cccactaact tggtcctacc cagcaatggc tcaatgcaca actattgccc      720

acagcagact aaaattactt cagcttttaa atacattaac actgtgatat cttgtactat      780

tttcatcgtg ggaatggtgg ggaatgcaac tctgctcagg atcatttacc agaacaaatg      840

tatgaggaat ggccccaacg cgctgatagc cagccttgcc cttggagacc ttatctatgt      900

ggtcattgat ctccctatca atgtatttaa gctgctggct gggcgctggc cttttgatca      960

caatgacttt ggcgtatttc tttgcaagct gttccccttt ttgcagaagt cctcagtggg     1020

gatcaccgtc ctcaacctct gcgctcttag tgttgacagg tacagagcag ttgcctcctg     1080

gagtcgtgtt cagggaattg ggattccttt ggtaactgcc attgaaattg tctccatctg     1140

gatcctgtcc ttcatcctgg ccattcctga agcgattggc ttcgtcatgg taccctttga     1200

atataggggt gaacagcata aaacctgtat gctcaatgct acgtcaaaat tcatggagtt     1260

ctaccaagat gtaaaggact ggtggctctt tgggttctat ttctgtatgc ccttggtgtg     1320

cactgcgatc ttctacaccc tcatgacttg tgagatgttg aacagaagga atggcagctt     1380

gagaattgcc ctcagtgaac atcttaagca gcgtcgagaa gtggcaaaaa cagttttctg     1440

cttggtcgta atttttgctc tgtgctggtt ccctcttcat ttaagccgta tattgaagaa     1500

aaccgtgtat aatgagatgg acaagaaccg atgtgaatta cttagtttct tgctgctcat     1560

ggattacatc ggtattaact tggcaaccat gaattcatgt ataaacccca tagctctgta     1620

ttttgtgagc aagaaattta aaaattgttt ccagtcatgc ctctgctgct gctgttacca     1680

gtccaaaagt ctgatgacct cggtccccat gaacggaaca agcatccagt ggaagaacca     1740

cgaacaaaac aaccacaaca cagaccggag cagccacaag gacagcatga actgaccacc     1800

ctgcgaagca ctcctgggta ctcccataat cctctgggag aaaaaaatca caaggcaact     1860

gtgactccgg aaatctcttc tctgatcctt cttccttaac tcactcccac acccaagaag     1920

aaatgctttc caaaaccgca agggtagacc ggtttagcca cccacgacat ctaccaatcg     1980

tacttcttta attaatctga tttacatatt ccgcgtgttg tattcagcac taaaaaatgg     2040

tgggagctgg gagagaatga agactgttca atgaaaccag aaggatattt actacttttg     2100

catgaaaata gagctttcaa gtacatgggt agcttttatg gcagttctgg tgaatgttca     2160

gtgggaactg gtcaccatga aactttagag attatgacaa gattttctac tttttttaac     2220

tgattttttg tccttcagcc aaacacaata tgggctcaag ttacttttat ttgaaatgtc     2280

atttggtgcc agtatttttt aactgcataa tagcctaaca tgactatttg aacttattta     2340

cacatagttt gcaaaaaaaa aaagacaaaa atagtattca ggtgagcaat taggttagta     2400

ttttctatgt cactgtttat ttttttaaaa cacaaattct aaagctacaa caaatactac     2460

aggcccttaa aacacagtct gatgatacat ttg                                  2493


<210>  4
<211>  427
<212>  PRT
<213>  

<400>  4

Met Glu Thr Val Cys Leu Arg Ala Ser Phe Trp Leu Ala Leu Val Gly 
1               5                   10                  15      


Cys Val Ile Ser Asp Asn Ala Glu Arg Tyr Ser Thr Asn Leu Ser Asn 
            20                  25                  30          


His Val Asp Asp Phe Thr Thr Phe His Gly Thr Glu Leu Ser Leu Leu 
        35                  40                  45              


Val Thr Thr His Gln Pro Thr Asn Leu Val Leu Pro Ser Asn Gly Ser 
    50                  55                  60                  


Met His Asn Tyr Cys Pro Gln Gln Thr Lys Ile Thr Ser Ala Phe Lys 
65                  70                  75                  80  


Tyr Ile Asn Thr Val Ile Ser Cys Thr Ile Phe Ile Val Gly Met Val 
                85                  90                  95      


Gly Asn Ala Thr Leu Leu Arg Ile Ile Tyr Gln Asn Lys Cys Met Arg 
            100                 105                 110         


Asn Gly Pro Asn Ala Leu Ile Ala Ser Leu Ala Leu Gly Asp Leu Ile 
        115                 120                 125             


Tyr Val Val Ile Asp Leu Pro Ile Asn Val Phe Lys Leu Leu Ala Gly 
    130                 135                 140                 


Arg Trp Pro Phe Asp His Asn Asp Phe Gly Val Phe Leu Cys Lys Leu 
145                 150                 155                 160 


Phe Pro Phe Leu Gln Lys Ser Ser Val Gly Ile Thr Val Leu Asn Leu 
                165                 170                 175     


Cys Ala Leu Ser Val Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
            180                 185                 190         


Val Gln Gly Ile Gly Ile Pro Leu Val Thr Ala Ile Glu Ile Val Ser 
        195                 200                 205             


Ile Trp Ile Leu Ser Phe Ile Leu Ala Ile Pro Glu Ala Ile Gly Phe 
    210                 215                 220                 


Val Met Val Pro Phe Glu Tyr Arg Gly Glu Gln His Lys Thr Cys Met 
225                 230                 235                 240 


Leu Asn Ala Thr Ser Lys Phe Met Glu Phe Tyr Gln Asp Val Lys Asp 
                245                 250                 255     


Trp Trp Leu Phe Gly Phe Tyr Phe Cys Met Pro Leu Val Cys Thr Ala 
            260                 265                 270         


Ile Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Asn Arg Arg Asn Gly 
        275                 280                 285             


Ser Leu Arg Ile Ala Leu Ser Glu His Leu Lys Gln Arg Arg Glu Val 
    290                 295                 300                 


Ala Lys Thr Val Phe Cys Leu Val Val Ile Phe Ala Leu Cys Trp Phe 
305                 310                 315                 320 


Pro Leu His Leu Ser Arg Ile Leu Lys Lys Thr Val Tyr Asn Glu Met 
                325                 330                 335     


Asp Lys Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Leu Met Asp Tyr 
            340                 345                 350         


Ile Gly Ile Asn Leu Ala Thr Met Asn Ser Cys Ile Asn Pro Ile Ala 
        355                 360                 365             


Leu Tyr Phe Val Ser Lys Lys Phe Lys Asn Cys Phe Gln Ser Cys Leu 
    370                 375                 380                 


Cys Cys Cys Cys Tyr Gln Ser Lys Ser Leu Met Thr Ser Val Pro Met 
385                 390                 395                 400 


Asn Gly Thr Ser Ile Gln Trp Lys Asn His Glu Gln Asn Asn His Asn 
                405                 410                 415     


Thr Asp Arg Ser Ser His Lys Asp Ser Met Asn 
            420                 425         



<210>  5
<211>  1436
<212>  DNA
<213>  

<400>  5
gtgagaccaa cataacagga cgtttcttca gatccacatt aagatgggtg tcctttgctt       60

tctggcgtcc ttttggctgg ccctggtggg aggcgcaatc gctgacaatg ctgagagata      120

cagtgctaat ctaagcagcc acgtggagga cttcacccct tttccaggga cagagttcga      180

ctttctgggc accacccttc gaccccctaa tttggccctg cctagcaatg gctcaatgca      240

tggctattgc ccacagcaga caaaaatcac gacggctttc aaatatatca acactgtgat      300

atcctgtacc attttcatcg tgggaatggt ggggaacgcc actctcctaa gaatcattta      360

ccaaaacaag tgtatgagga acggccccaa tgcgctcata gccagcctgg cccttggaga      420

ccttatctac gtggtcattg atctccccat caatgtgttt aagctgttgg cggggcgctg      480

gccttttgac cacaatgatt ttggagtgtt tctctgcaag ctgttcccct ttttgcagaa      540

gtcgtccgtg ggcatcactg tcctgaatct ctgcgctctc agtgtggaca ggtacagagc      600

agtggcttcc tggagccggg ttcaaggaat cgggatcccc ttgattaccg ccattgaaat      660

tgtctccatc tggatccttt cctttatctt ggccatccca gaagcaatcg gcttcgtcat      720

ggtacccttc gaatacaagg gcgagcagca caggacctgc atgctcaacg ccacgaccaa      780

gttcatggag ttttaccaag acgtgaagga ctggtggctc tttggattct acttctgcat      840

gcccttggtg tgcacagcaa tcttctatac cctcatgacc tgtgagatgc tcaacagaag      900

gaatgggagc ttgcggattg ccctcagcga acacctcaag cagcgtcgag aggtggcaaa      960

gaccgtcttc tgcttggttg tcatcttcgc cctgtgctgg ttccctcttc acttaagccg     1020

aattttgaag aaaaccgtct atgatgagat ggataagaac cggtgtgaac tgctcagctt     1080

cttgctgctc atggattaca ttggcattaa cctggcaacc atgaactctt gcataaaccc     1140

aatagctctg tattttgtga gcaagaaatt caaaaattgt tttcagtcat gcctctgttg     1200

ctgttgtcac cagtccaaaa gcctcatgac ctcggtcccc atgaatggaa cgagtatcca     1260

gtggaagaac caggagcaga accacaacac agaacggagc agccacaagg acagcatgaa     1320

ctaaccctgt gcagaagcac cgagcagtgt gccttcgagt cccaggatga aacggtcacg     1380

cagcagctgc gctcccaaaa cctcccaggt ctctcccctg ctttttgtct aagctt         1436


<210>  6
<211>  426
<212>  PRT
<213>  

<400>  6

Met Gly Val Leu Cys Phe Leu Ala Ser Phe Trp Leu Ala Leu Val Gly 
1               5                   10                  15      


Gly Ala Ile Ala Asp Asn Ala Glu Arg Tyr Ser Ala Asn Leu Ser Ser 
            20                  25                  30          


His Val Glu Asp Phe Thr Pro Phe Pro Gly Thr Glu Phe Asp Phe Leu 
        35                  40                  45              


Gly Thr Thr Leu Arg Pro Pro Asn Leu Ala Leu Pro Ser Asn Gly Ser 
    50                  55                  60                  


Met His Gly Tyr Cys Pro Gln Gln Thr Lys Ile Thr Thr Ala Phe Lys 
65                  70                  75                  80  


Tyr Ile Asn Thr Val Ile Ser Cys Thr Ile Phe Ile Val Gly Met Val 
                85                  90                  95      


Gly Asn Ala Thr Leu Leu Arg Ile Ile Tyr Gln Asn Lys Cys Met Arg 
            100                 105                 110         


Asn Gly Pro Asn Ala Leu Ile Ala Ser Leu Ala Leu Gly Asp Leu Ile 
        115                 120                 125             


Tyr Val Val Ile Asp Leu Pro Ile Asn Val Phe Lys Leu Leu Ala Gly 
    130                 135                 140                 


Arg Trp Pro Phe Asp His Asn Asp Phe Gly Val Phe Leu Cys Lys Leu 
145                 150                 155                 160 


Phe Pro Phe Leu Gln Lys Ser Ser Val Gly Ile Thr Val Leu Asn Leu 
                165                 170                 175     


Cys Ala Leu Ser Val Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
            180                 185                 190         


Val Gln Gly Ile Gly Ile Pro Leu Ile Thr Ala Ile Glu Ile Val Ser 
        195                 200                 205             


Ile Trp Ile Leu Ser Phe Ile Leu Ala Ile Pro Glu Ala Ile Gly Phe 
    210                 215                 220                 


Val Met Val Pro Phe Glu Tyr Lys Gly Glu Gln His Arg Thr Cys Met 
225                 230                 235                 240 


Leu Asn Ala Thr Thr Lys Phe Met Glu Phe Tyr Gln Asp Val Lys Asp 
                245                 250                 255     


Trp Trp Leu Phe Gly Phe Tyr Phe Cys Met Pro Leu Val Cys Thr Ala 
            260                 265                 270         


Ile Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Asn Arg Arg Asn Gly 
        275                 280                 285             


Ser Leu Arg Ile Ala Leu Ser Glu His Leu Lys Gln Arg Arg Glu Val 
    290                 295                 300                 


Ala Lys Thr Val Phe Cys Leu Val Val Ile Phe Ala Leu Cys Trp Phe 
305                 310                 315                 320 


Pro Leu His Leu Ser Arg Ile Leu Lys Lys Thr Val Tyr Asp Glu Met 
                325                 330                 335     


Asp Lys Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Leu Met Asp Tyr 
            340                 345                 350         


Ile Gly Ile Asn Leu Ala Thr Met Asn Ser Cys Ile Asn Pro Ile Ala 
        355                 360                 365             


Leu Tyr Phe Val Ser Lys Lys Phe Lys Asn Cys Phe Gln Ser Cys Leu 
    370                 375                 380                 


Cys Cys Cys Cys His Gln Ser Lys Ser Leu Met Thr Ser Val Pro Met 
385                 390                 395                 400 


Asn Gly Thr Ser Ile Gln Trp Lys Asn Gln Glu Gln Asn His Asn Thr 
                405                 410                 415     


Glu Arg Ser Ser His Lys Asp Ser Met Asn 
            420                 425     


<210>  7
<211>  33
<212>  DNA
<213>  С

<400>  7
agggccagtc agaacattgg cacaagcata cac                                    33


<210>  8
<211>  11
<212>  PRT
<213>  С

<400>  8

Arg Ala Ser Gln Asn Ile Gly Thr Ser Ile His 
1               5                   10      


<210>  9
<211>  33
<212>  DNA
<213>  С

<400>  9
cgagcaagtg aaaatattta cagttattta gca                                    33


<210>  10
<211>  11
<212>  PRT
<213>  С

<400>  10

Arg Ala Ser Glu Asn Ile Tyr Ser Tyr Leu Ala 
1               5                   10      


<210>  11
<211>  39
<212>  DNA
<213>  С

<400>  11
cagagcctct ttgatattga tggaaagaca tatttgaat                              39


<210>  12
<211>  13
<212>  PRT
<213>  С

<400>  12

Gln Ser Leu Phe Asp Ile Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10              


<210>  13
<211>  33
<212>  DNA
<213>  С

<400>  13
cgggcaagtc aggacattgg tggtagctta aac                                    33


<210>  14
<211>  11
<212>  PRT
<213>  С

<400>  14

Arg Ala Ser Gln Asp Ile Gly Gly Ser Leu Asn 
1               5                   10      


<210>  15
<211>  33
<212>  DNA
<213>  С

<400>  15
agggccagcc agactattag cgacttctta cac                                    33


<210>  16
<211>  11
<212>  PRT
<213>  С

<400>  16

Arg Ala Ser Gln Thr Ile Ser Asp Phe Leu His 
1               5                   10      


<210>  17
<211>  33
<212>  DNA
<213>  С

<400>  17
agggcaagtg aggacataca cactcaatta gcc                                    33


<210>  18
<211>  11
<212>  PRT
<213>  С

<400>  18

Arg Ala Ser Glu Asp Ile His Thr Gln Leu Ala 
1               5                   10      


<210>  19
<211>  48
<212>  DNA
<213>  С

<400>  19
agatctagtc agtacattgt tcatagtact ggaaccacct atttagaa                    48


<210>  20
<211>  16
<212>  PRT
<213>  С

<400>  20

Arg Ser Ser Gln Tyr Ile Val His Ser Thr Gly Thr Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  21
<211>  48
<212>  DNA
<213>  С

<400>  21
agatctagtc attaccttgt tcatgataac ggaaacacct atgttgaa                    48


<210>  22
<211>  16
<212>  PRT
<213>  С

<400>  22

Arg Ser Ser His Tyr Leu Val His Asp Asn Gly Asn Thr Tyr Val Glu 
1               5                   10                  15      


<210>  23
<211>  48
<212>  DNA
<213>  С

<400>  23
agatctagtc agaacattgt ccatagtact ggaaacacct atttagaa                    48


<210>  24
<211>  16
<212>  PRT
<213>  С

<400>  24

Arg Ser Ser Gln Asn Ile Val His Ser Thr Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  25
<211>  30
<212>  DNA
<213>  С

<400>  25
agtgtcagct caagtgtaag ttacatacac                                        30


<210>  26
<211>  10
<212>  PRT
<213>  С

<400>  26

Ser Val Ser Ser Ser Val Ser Tyr Ile His 
1               5                   10  


<210>  27
<211>  30
<212>  DNA
<213>  С

<400>  27
agtgccagct caagtgtaag ttacatgtgc                                        30


<210>  28
<211>  10
<212>  PRT
<213>  С

<400>  28

Ser Ala Ser Ser Ser Val Ser Tyr Met Cys 
1               5                   10  


<210>  29
<211>  18
<212>  DNA
<213>  С

<400>  29
cagggcatta acaattat                                                     18


<210>  30
<211>  6
<212>  PRT
<213>  С

<400>  30

Gln Gly Ile Asn Asn Tyr 
1               5       


<210>  31
<211>  21
<212>  DNA
<213>  С

<400>  31
tatgcttcta agtctatatc t                                                 21


<210>  32
<211>  7
<212>  PRT
<213>  С

<400>  32

Tyr Ala Ser Lys Ser Ile Ser 
1               5           


<210>  33
<211>  21
<212>  DNA
<213>  С

<400>  33
aatgcaaaaa ccttagcaga a                                                 21


<210>  34
<211>  7
<212>  PRT
<213>  С

<400>  34

Asn Ala Lys Thr Leu Ala Glu 
1               5           


<210>  35
<211>  21
<212>  DNA
<213>  С

<400>  35
ctggtgtctg aattggactc t                                                 21


<210>  36
<211>  7
<212>  PRT
<213>  С

<400>  36

Leu Val Ser Glu Leu Asp Ser 
1               5           


<210>  37
<211>  21
<212>  DNA
<213>  С

<400>  37
gccacatcca gcttagattc t                                                 21


<210>  38
<211>  7
<212>  PRT
<213>  С

<400>  38

Ala Thr Ser Ser Leu Asp Ser 
1               5           


<210>  39
<211>  21
<212>  DNA
<213>  С

<400>  39
tatgcttccc aatccatctc t                                                 21


<210>  40
<211>  7
<212>  PRT
<213>  С

<400>  40

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  41
<211>  21
<212>  DNA
<213>  С

<400>  41
ggtgcagcca gtttgaaaag t                                                 21


<210>  42
<211>  7
<212>  PRT
<213>  С

<400>  42

Gly Ala Ala Ser Leu Lys Ser 
1               5           


<210>  43
<211>  21
<212>  DNA
<213>  С

<400>  43
aaagtttcca accgattttc t                                                 21


<210>  44
<211>  7
<212>  PRT
<213>  С

<400>  44

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  45
<211>  21
<212>  DNA
<213>  С

<400>  45
gacacatcca aactggcttc t                                                 21


<210>  46
<211>  7
<212>  PRT
<213>  С

<400>  46

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  47
<211>  21
<212>  DNA
<213>  С

<400>  47
tatacatcaa ctttacagtc a                                                 21


<210>  48
<211>  7
<212>  PRT
<213>  С

<400>  48

Tyr Thr Ser Thr Leu Gln Ser 
1               5           


<210>  49
<211>  27
<212>  DNA
<213>  С

<400>  49
caacatagtt atagcttccc gtggacg                                           27


<210>  50
<211>  9
<212>  PRT
<213>  С

<400>  50

Gln His Ser Tyr Ser Phe Pro Trp Thr 
1               5                   


<210>  51
<211>  27
<212>  DNA
<213>  С

<400>  51
cagcatcatt atggtattcc gttcacg                                           27


<210>  52
<211>  9
<212>  PRT
<213>  С

<400>  52

Gln His His Tyr Gly Ile Pro Phe Thr 
1               5                   


<210>  53
<211>  27
<212>  DNA
<213>  С

<400>  53
tggcaaggta cacattttcc gctcacg                                           27


<210>  54
<211>  9
<212>  PRT
<213>  С

<400>  54

Trp Gln Gly Thr His Phe Pro Leu Thr 
1               5                   


<210>  55
<211>  27
<212>  DNA
<213>  С

<400>  55
ctacaatatg ctagttctcc gtatacg                                           27


<210>  56
<211>  9
<212>  PRT
<213>  С

<400>  56

Leu Gln Tyr Ala Ser Ser Pro Tyr Thr 
1               5                   


<210>  57
<211>  27
<212>  DNA
<213>  С

<400>  57
caaagtggta acacctttcc gtggacg                                           27


<210>  58
<211>  9
<212>  PRT
<213>  С

<400>  58

Gln Ser Gly Asn Thr Phe Pro Trp Thr 
1               5                   


<210>  59
<211>  27
<212>  DNA
<213>  С

<400>  59
caacagtata ggagtattcc gtggacg                                           27


<210>  60
<211>  9
<212>  PRT
<213>  С

<400>  60

Gln Gln Tyr Arg Ser Ile Pro Trp Thr 
1               5                   


<210>  61
<211>  27
<212>  DNA
<213>  С

<400>  61
tttcaaggtt cacattttcc attcacg                                           27


<210>  62
<211>  9
<212>  PRT
<213>  С

<400>  62

Phe Gln Gly Ser His Phe Pro Phe Thr 
1               5                   


<210>  63
<211>  27
<212>  DNA
<213>  С

<400>  63
tttcaaggtt cacatttccc attcacg                                           27


<210>  64
<211>  9
<212>  PRT
<213>  С

<400>  64

His Gln Trp Ser Thr Asn Pro Pro Thr 
1               5                   


<210>  65
<211>  27
<212>  DNA
<213>  С

<400>  65
cagcagtgga gtagtaaccc acccacg                                           27


<210>  66
<211>  9
<212>  PRT
<213>  С

<400>  66

Gln Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  67
<211>  24
<212>  DNA
<213>  С

<400>  67
cagcagttta gtaaacttcg gaca                                              24


<210>  68
<211>  8
<212>  PRT
<213>  С

<400>  68

Gln Gln Phe Ser Lys Leu Arg Thr 
1               5               


<210>  69
<211>  36
<212>  DNA
<213>  С

<400>  69
gggttctcac tgaccacttc tggcttgggt gttgcc                                 36


<210>  70
<211>  12
<212>  PRT
<213>  С

<400>  70

Gly Phe Ser Leu Thr Thr Ser Gly Leu Gly Val Ala 
1               5                   10          


<210>  71
<211>  30
<212>  DNA
<213>  С

<400>  71
ggctacacct ttactagcta ctggatacac                                        30


<210>  72
<211>  10
<212>  PRT
<213>  С

<400>  72

Gly Tyr Thr Phe Thr Ser Tyr Trp Ile His 
1               5                   10  


<210>  73
<211>  30
<212>  DNA
<213>  С

<400>  73
ggcctcaaca ttaaagacat ctatattcac                                        30


<210>  74
<211>  10
<212>  PRT
<213>  С

<400>  74

Gly Leu Asn Ile Lys Asp Ile Tyr Ile His 
1               5                   10  


<210>  75
<211>  30
<212>  DNA
<213>  С

<400>  75
ggttactcat tcaccaacta ctggatacac                                        30


<210>  76
<211>  10
<212>  PRT
<213>  С

<400>  76

Gly Tyr Ser Phe Thr Asn Tyr Trp Ile His 
1               5                   10  


<210>  77
<211>  30
<212>  DNA
<213>  С

<400>  77
ggattcactt tcagtgacta tcccatgtct                                        30


<210>  78
<211>  10
<212>  PRT
<213>  С

<400>  78

Gly Phe Thr Phe Ser Asp Tyr Pro Met Ser 
1               5                   10  


<210>  79
<211>  30
<212>  DNA
<213>  С

<400>  79
ggattcactt tcagtagctt tggcatgtct                                        30


<210>  80
<211>  10
<212>  PRT
<213>  С

<400>  80

Gly Phe Thr Phe Ser Ser Phe Gly Met Ser 
1               5                   10  


<210>  81
<211>  30
<212>  DNA
<213>  С

<400>  81
ggattcactt tcagtaccta tggcatgtct                                        30


<210>  82
<211>  10
<212>  PRT
<213>  С

<400>  82

Gly Phe Thr Phe Ser Thr Tyr Gly Met Ser 
1               5                   10  


<210>  83
<211>  30
<212>  DNA
<213>  С

<400>  83
ggattcactt tcagtagtta tggcatgtct                                        30


<210>  84
<211>  10
<212>  PRT
<213>  С

<400>  84

Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser 
1               5                   10  


<210>  85
<211>  36
<212>  DNA
<213>  С

<400>  85
gggttttcac tgaccacttc tggtatgggt gtaggc                                 36


<210>  86
<211>  12
<212>  PRT
<213>  С

<400>  86

Gly Phe Ser Leu Thr Thr Ser Gly Met Gly Val Gly 
1               5                   10          


<210>  87
<211>  36
<212>  DNA
<213>  С

<400>  87
ggattttcac tgagcacttc tggtttgggt gtaggc                                 36


<210>  88
<211>  12
<212>  PRT
<213>  С

<400>  88

Gly Phe Ser Leu Ser Thr Ser Gly Leu Gly Val Gly 
1               5                   10          


<210>  89
<211>  24
<212>  DNA
<213>  С

<400>  89
ggattcacct tcagtgatta ttac                                              24


<210>  90
<211>  8
<212>  PRT
<213>  С

<400>  90

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  91
<211>  48
<212>  DNA
<213>  С

<400>  91
cacatttggt cggatggtga cacgcgctat tacccagccc tgaagaac                    48


<210>  92
<211>  16
<212>  PRT
<213>  С

<400>  92

His Ile Trp Ser Asp Gly Asp Thr Arg Tyr Tyr Pro Ala Leu Lys Asn 
1               5                   10                  15      


<210>  93
<211>  36
<212>  DNA
<213>  С

<400>  93
tacattaatc ctgacactga ttatagtgag tacaat                                 36


<210>  94
<211>  12
<212>  PRT
<213>  С

<400>  94

Tyr Ile Asn Pro Asp Thr Asp Tyr Ser Glu Tyr Asn 
1               5                   10          


<210>  95
<211>  36
<212>  DNA
<213>  С

<400>  95
aggattgatc ctgcgaacgg taagactgca tatgac                                 36


<210>  96
<211>  12
<212>  PRT
<213>  С

<400>  96

Arg Ile Asp Pro Ala Asn Gly Lys Thr Ala Tyr Asp 
1               5                   10          


<210>  97
<211>  36
<212>  DNA
<213>  С

<400>  97
atgattgatc cttccgatgc tgaaactggg ttaaat                                 36


<210>  98
<211>  12
<212>  PRT
<213>  С

<400>  98

Met Ile Asp Pro Ser Asp Ala Glu Thr Gly Leu Asn 
1               5                   10          


<210>  99
<211>  24
<212>  DNA
<213>  С

<400>  99
gttagtgatg gtggtggttc cacc                                              24


<210>  100
<211>  8
<212>  PRT
<213>  С

<400>  100

Val Ser Asp Gly Gly Gly Ser Thr 
1               5               


<210>  101
<211>  24
<212>  DNA
<213>  С

<400>  101
attagtagtg ctggtagttt cacc                                              24


<210>  102
<211>  8
<212>  PRT
<213>  С

<400>  102

Ile Ser Ser Ala Gly Ser Phe Thr 
1               5               


<210>  103
<211>  51
<212>  DNA
<213>  С

<400>  103
accattaata ctaatggtgg taccacctat tatcgagaca gtgtgaaggg c                51


<210>  104
<211>  17
<212>  PRT
<213>  С

<400>  104

Thr Ile Asn Thr Asn Gly Gly Thr Thr Tyr Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  105
<211>  51
<212>  DNA
<213>  С

<400>  105
accataaata ctaatggtgg taacacctat tattcagaca atgtgaaggg c                51


<210>  106
<211>  17
<212>  PRT
<213>  С

<400>  106

Thr Ile Asn Thr Asn Gly Gly Asn Thr Tyr Tyr Ser Asp Asn Val Lys 
1               5                   10                  15      


Gly 
    


<210>  107
<211>  51
<212>  DNA
<213>  С

<400>  107
accattagta ctaatggtgc caccgccaat tatccagaca gtgtgaaggg c                51


<210>  108
<211>  17
<212>  PRT
<213>  С

<400>  108

Thr Ile Ser Thr Asn Gly Ala Thr Ala Asn Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  109
<211>  48
<212>  DNA
<213>  С

<400>  109
cacatttggt gggatgatga taagtactat aatccatccc tgaagagc                    48


<210>  110
<211>  16
<212>  PRT
<213>  С

<400>  110

His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  111
<211>  48
<212>  DNA
<213>  С

<400>  111
cacatttggt gggatgatga taagtactat aatccatccc ttaagaga                    48


<210>  112
<211>  16
<212>  PRT
<213>  С

<400>  112

His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ser Leu Lys Arg 
1               5                   10                  15      


<210>  113
<211>  30
<212>  DNA
<213>  С

<400>  113
attagaaatc gggctaatgg ttacacaaca                                        30


<210>  114
<211>  10
<212>  PRT
<213>  С

<400>  114

Ile Arg Asn Arg Ala Asn Gly Tyr Thr Thr 
1               5                   10  


<210>  115
<211>  30
<212>  DNA
<213>  С

<400>  115
atgaaggatg atagtcttta ctttgacaac                                        30


<210>  116
<211>  10
<212>  PRT
<213>  С

<400>  116

Met Lys Asp Asp Ser Leu Tyr Phe Asp Asn 
1               5                   10  


<210>  117
<211>  30
<212>  DNA
<213>  С

<400>  117
gcaagtgctg gttattattt ttttgacttc                                        30


<210>  118
<211>  10
<212>  PRT
<213>  С

<400>  118

Ala Ser Ala Gly Tyr Tyr Phe Phe Asp Phe 
1               5                   10  


<210>  119
<211>  15
<212>  DNA
<213>  С

<400>  119
ggtagggggg cccac                                                        15


<210>  120
<211>  5
<212>  PRT
<213>  С

<400>  120

Gly Arg Gly Ala His 
1               5   


<210>  121
<211>  33
<212>  DNA
<213>  С

<400>  121
gcaagaattg gcgattacta taatatggac tac                                    33


<210>  122
<211>  11
<212>  PRT
<213>  С

<400>  122

Ala Arg Ile Gly Asp Tyr Tyr Asn Met Asp Tyr 
1               5                   10      


<210>  123
<211>  45
<212>  DNA
<213>  С

<400>  123
acaagacatg cttcctacta tagctacgac cattctatgg actac                       45


<210>  124
<211>  15
<212>  PRT
<213>  С

<400>  124

Thr Arg His Ala Ser Tyr Tyr Ser Tyr Asp His Ser Met Asp Tyr 
1               5                   10                  15  


<210>  125
<211>  36
<212>  DNA
<213>  С

<400>  125
gcaagacggg ggtacgacgt tgggtgcttt gaccac                                 36


<210>  126
<211>  12
<212>  PRT
<213>  С

<400>  126

Ala Arg Arg Gly Tyr Asp Val Gly Cys Phe Asp His 
1               5                   10          


<210>  127
<211>  27
<212>  DNA
<213>  С

<400>  127
gcaagagact acggggctat ggactac                                           27


<210>  128
<211>  9
<212>  PRT
<213>  С

<400>  128

Ala Arg Asp Tyr Gly Ala Met Asp Tyr 
1               5                   


<210>  129
<211>  27
<212>  DNA
<213>  С

<400>  129
gcaactgaaa agggagctat gggctac                                           27


<210>  130
<211>  9
<212>  PRT
<213>  С

<400>  130

Ala Thr Glu Lys Gly Ala Met Gly Tyr 
1               5                   


<210>  131
<211>  57
<212>  DNA
<213>  С

<400>  131
gctcgaagaa ctgagactat gattacgaca gtgctatatt actatgctat ggactac          57


<210>  132
<211>  19
<212>  PRT
<213>  С

<400>  132

Ala Arg Arg Thr Glu Thr Met Ile Thr Thr Val Leu Tyr Tyr Tyr Ala 
1               5                   10                  15      


Met Asp Tyr 
            


<210>  133
<211>  54
<212>  DNA
<213>  С

<400>  133
gctcgaagga gggaagttaa cttcggtatt aactattact attctatgga ctac             54


<210>  134
<211>  18
<212>  PRT
<213>  С

<400>  134

Ala Arg Arg Arg Glu Val Asn Phe Gly Ile Asn Tyr Tyr Tyr Ser Met 
1               5                   10                  15      


Asp Tyr 
        


<210>  135
<211>  36
<212>  DNA
<213>  С

<400>  135
gtaagagatt cctatcacta cgggtacttc gatgtc                                 36


<210>  136
<211>  12
<212>  PRT
<213>  С

<400>  136

Val Arg Asp Ser Tyr His Tyr Gly Tyr Phe Asp Val 
1               5                   10          


<210>  137
<211>  324
<212>  DNA
<213>  С

<400>  137
gacatcttgc tgactcagtc tccagccatc ctgtctgtga gtccaggaaa aagagtcagt       60

ttctcctgca gggccagtca gaacattggc acaagcatac actggtatca gcaaagaaca      120

aatggttctc caaggcttct cataaagtat gcttctaagt ctatatctgg gatttcttcc      180

aggtttagtg gcagtggctc agggacagat tttactctta gtatcaacag tgtggagtct      240

gaagatattg cagcttatta ctgtcaacat agttatagct tcccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa acgg                                             324


<210>  138
<211>  108
<212>  PRT
<213>  С

<400>  138

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Lys Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Asn Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Lys Ser Ile Ser Gly Ile Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Ala Tyr Tyr Cys Gln His Ser Tyr Ser Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  139
<211>  324
<212>  DNA
<213>  С

<400>  139
gacatccaga tgactcagtc tccagcctcc ctatctacat ctgtgggaga aactgtcacc       60

atcacatgtc gagcaagtga aaatatttac agttatttag catggtatca gcagagacag      120

ggaaaatctc ctcacctcct ggtcaataat gcaaaaacct tagcagaagg tgtgccatca      180

aggttcagtg gcagtggatc aggcacacat ttttctctga ggatcagcgg cctgcagcct      240

gaagattttg ggagttatta ctgtcagcat cattatggta ttccgttcac gttcggaggg      300

gggaccaagt tgtcaataaa acgg                                             324


<210>  140
<211>  108
<212>  PRT
<213>  С

<400>  140

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Gln Gly Lys Ser Pro His Leu Leu Val 
        35                  40                  45              


Asn Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Phe Ser Leu Arg Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Ile Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Ser Ile Lys Arg 
            100                 105             


<210>  141
<211>  339
<212>  DNA
<213>  С

<400>  141
gatgttgtga tgacccagat tccactcact ttgtcggtta ccattggaca accagcctcc       60

atctcttgca agtcaagtca gagcctcttt gatattgatg gaaagacata tttgaattgg      120

ttgttacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc tgaattggac      180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgagga tttgggagtt tactattgtt ggcaaggtac acattttccg      300

ctcacgttcg gtgctgggac caagctggag ctgaaacgg                             339


<210>  142
<211>  113
<212>  PRT
<213>  С

<400>  142

Asp Val Val Met Thr Gln Ile Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Phe Asp Ile 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Glu Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg 
    


<210>  143
<211>  324
<212>  DNA
<213>  С

<400>  143
gacatccaga tgacccagtc tccatcctcc ttatctgcct ctctgggaga aagagtcagt       60

ctcacttgtc gggcaagtca ggacattggt ggtagcttaa actggcttca gcagaaacca      120

gatggaacta ttaaacgcct gatctacgcc acatccagct tagattctgg tgtccccaaa      180

aggttcagtg gcagtaggtc tgggtcagtt ttttctctca ccatcaccag ccttgagtct      240

gaagattttg tagactattt ctgtctacaa tatgctagtt ctccgtatac gttcggaggg      300

gggaccaagc tggaaataaa acgg                                             324


<210>  144
<211>  108
<212>  PRT
<213>  С

<400>  144

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Gly Ser 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Val Phe Ser Leu Thr Ile Thr Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Val Asp Tyr Phe Cys Leu Gln Tyr Ala Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  145
<211>  324
<212>  DNA
<213>  С

<400>  145
gacattgtga tgactcagtc tccagccacc ctgtctgtga ctccaggaga tagagtctct       60

ctttcctgca gggccagcca gactattagc gacttcttac actggtatca acaaaaatca      120

catgagtctc caaggcttct catcaaatat gcttcccaat ccatctctgg gatcccctcc      180

aggttcagtg gcactggatc agggtcagat ttcactctca ctatcaacag tgtggaacct      240

gaagatgttg gagtgtatta ctgtcaaagt ggtaacacct ttccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa acgg                                             324


<210>  146
<211>  108
<212>  PRT
<213>  С

<400>  146

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Thr Ile Ser Asp Phe 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Asn Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Gln Ser Gly Asn Thr Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  147
<211>  324
<212>  DNA
<213>  С

<400>  147
gacatccaga tgacacaatc ttcatcctcc ttttctggat ttctaggaga cagagtcacc       60

attacttgca gggcaagtga ggacatacac actcaattag cctggtatca gcagaaacca      120

ggaaatgctc ctaggctctt aatatctggt gcagccagtt tgaaaagtgg ggttccttca      180

agattcagtg gcactggatc tggaaaggat tacactctca gcattaccag tcttcagact      240

gaagatgttg ctacatatta ctgtcaacag tataggagta ttccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa acgg                                             324


<210>  148
<211>  108
<212>  PRT
<213>  С

<400>  148

Asp Ile Gln Met Thr Gln Ser Ser Ser Ser Phe Ser Gly Phe Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile His Thr Gln 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Ala Ser Leu Lys Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Arg Ser Ile Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  149
<211>  339
<212>  DNA
<213>  С

<400>  149
gatgttttga tgacccaaac tccgctctcc ctgcctgtca gtcttggaga tcacgcctcc       60

atctcttgca gatctagtca gtacattgtt catagtactg gaaccaccta tttagaatgg      120

tacctacaga aaccaggcca gtctccacag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cactggcagt ggatcaggga cagatttcac actcaggatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ttcaaggttc acattttcca      300

ttcacgttcg gctcggggac aaagttggaa ataaaacgg                             339


<210>  150
<211>  113
<212>  PRT
<213>  С

<400>  150

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp His Ala Ser Ile Ser Cys Arg Ser Ser Gln Tyr Ile Val His Ser 
            20                  25                  30          


Thr Gly Thr Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Phe Gln Gly 
                85                  90                  95      


Ser His Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  151
<211>  339
<212>  DNA
<213>  С

<400>  151
gaagttgtga tgacccaaac tccactctcc ttgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca ttaccttgtt catgataacg gaaacaccta tgttgaatgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaggtttc caaccgattt      180

tctggagtcc cagacaggtt tactggcagt ggttcaggga cagatttcac actcaagatc      240

agcagagtgg agtctgagga tctgggaatt tattactgct ttcaaggttc acatttccca      300

ttcacgttcg gctcggggac agagttggaa ataaaacgg                             339


<210>  152
<211>  113
<212>  PRT
<213>  С

<400>  152

Glu Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser His Tyr Leu Val His Asp 
            20                  25                  30          


Asn Gly Asn Thr Tyr Val Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ser Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Phe Pro Phe Thr Phe Gly Ser Gly Thr Glu Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  153
<211>  339
<212>  DNA
<213>  С

<400>  153
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gaacattgtc catagtactg gaaacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag ctcctgattt ataaagtttc caaccgattt      180

tctggggtcc caaacaggtt ccgtggcagt ggatcaggga cagatttcac actcaagatc      240

accagagtgg aggctgagga tctgggaatt tattactgct ttcaaggttc acattttcca      300

ttcacgttcg gctcggggac aaagttggaa ataaaacgg                             339


<210>  154
<211>  113
<212>  PRT
<213>  С

<400>  154

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser 
            20                  25                  30          


Thr Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asn Arg Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Thr Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  155
<211>  321
<212>  DNA
<213>  С

<400>  155
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgtcagctc aagtgtaagt tacatacact ggtaccaaca gaagtcaggc      120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccaccagtgg agtactaacc cacccacgtt cggagggggg      300

accaagctgg aaataagacg g                                                321


<210>  156
<211>  107
<212>  PRT
<213>  С

<400>  156

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Val Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys His Gln Trp Ser Thr Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg Arg 
            100                 105         


<210>  157
<211>  321
<212>  DNA
<213>  С

<400>  157
caaattgttc tcacccagtc tccagcactc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tacatgtgct ggtaccagca gaagccaaga      120

tcctccccca aaccctggat ttatctcaca tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagtagcat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtagtaacc cacccacgtt cggtgctggg      300

accaagctgg agctgaaacg g                                                321


<210>  158
<211>  107
<212>  PRT
<213>  С

<400>  158

Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Cys Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105         


<210>  159
<211>  321
<212>  DNA
<213>  С

<400>  159
gaaatccaga tgacacagac tccatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcacttgca gtgcaagtca gggcattaac aattatttga actggtatca gcagaaacca      120

ggtggaaaga ctagactcct catctattat acatcaactt tacagtcagg agtcccatca      180

aggttcagtg gcagtgggtc tgggacacat tattctctca ccatcagcaa tctggaacct      240

gaagatattg ccacttacta ttgtcagcag tttagtaaac ttcggacatt cggtggaggc      300

accaggctgg aaatcaaacg g                                                321


<210>  160
<211>  107
<212>  PRT
<213>  С

<400>  160

Glu Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Gly Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gly Lys Thr Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr His Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Phe Ser Lys Leu Arg Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys Arg 
            100                 105         


<210>  161
<211>  324
<212>  DNA
<213>  

<400>  161
gagattgtgc tgactcagag tccagacttc cagtcagtga cccccaagga gaaagtcacc       60

atcacatgcc gggcaagcca gaacatcggc acaagcattc actggtacca gcagaagccc      120

gatcagtccc ctaagctgct gatcaaatat gcctctaaga gtatttcagg ggtgccctct      180

agattcagcg gctccgggtc tggaacagac tttactctga ccattaactc cctggaggct      240

gaagatgccg ctacttacta ttgtcagcat agctactcat tcccttggac attcgggcag      300

gggaccaaag tggaaatcaa acgt                                             324


<210>  162
<211>  108
<212>  PRT
<213>  

<400>  162

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Lys Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Tyr Ser Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  163
<211>  339
<212>  DNA
<213>  

<400>  163
gatattgtga tgacccaaac tccgctctcc ctgtccgtca cccctggaca gccggcctcc       60

atctcttgca gatctagtca gaacattgtt catagtactg gaaacaccta tttagaatgg      120

tacctacaga aaccaggcca gtctccacag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaaaatc      240

agcagagtgg aggctgagga tgttggagtt tattactgct ttcaaggttc acattttcca      300

ttcacgttcg gccaagggac caaggtggaa atcaaacgt                             339


<210>  164
<211>  113
<212>  PRT
<213>  

<400>  164

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Ser 
            20                  25                  30          


Thr Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Phe Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  165
<211>  360
<212>  DNA
<213>  С

<400>  165
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg       60

acttgttctt tctctgggtt ctcactgacc acttctggct tgggtgttgc ctggattcgt      120

cagccttcag ggaagggtct ggagtggctg gcacacattt ggtcggatgg tgacacgcgc      180

tattacccag ccctgaagaa ccgactgaca atctccaagg attcctccag caaccaggtc      240

ttcctcaaga tcgcccgtgt ggacactgca gatactgcca catactactg tgctcgaatg      300

aaggatgata gtctttactt tgacaactgg ggccaaggca ctattttcac agtctcctca      360


<210>  166
<211>  120
<212>  PRT
<213>  С

<400>  166

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Thr Thr Ser 
            20                  25                  30          


Gly Leu Gly Val Ala Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Ser Asp Gly Asp Thr Arg Tyr Tyr Pro Ala 
    50                  55                  60                  


Leu Lys Asn Arg Leu Thr Ile Ser Lys Asp Ser Ser Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Arg Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met Lys Asp Asp Ser Leu Tyr Phe Asp Asn Trp Gly Gln 
            100                 105                 110         


Gly Thr Ile Phe Thr Val Ser Ser 
        115                 120 


<210>  167
<211>  351
<212>  DNA
<213>  С

<400>  167
cagatccagt tggtgcagtc tggggctgaa ctggcaaaac ctggggcctc agtgaggatg       60

tcctgcgaga cttctggcta cacctttact agctactgga tacactggat aaaagagagg      120

cctggacagg gtctggaatg gattggatac attaatcctg acactgatta tagtgagtac      180

aatcagaaat tcaaggacaa ggccagattg actgcagaca aatcctccac cacagcctac      240

atggagctga acagcctgac atttgatgat tctgcagtct attactgtgc aagtgctggt      300

tattattttt ttgacttctg gggccaaggc accactctca cagtctcctc a               351


<210>  168
<211>  117
<212>  PRT
<213>  С

<400>  168

Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Met Ser Cys Glu Thr Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile His Trp Ile Lys Glu Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Asp Thr Asp Tyr Ser Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Arg Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Thr Phe Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ala Gly Tyr Tyr Phe Phe Asp Phe Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  169
<211>  336
<212>  DNA
<213>  С

<400>  169
gaggttcagc tgcagcagtc tggggcagaa cttgtgaaac caggggcctc agtcaagttg       60

tcctgtacaa cttctggcct caacattaaa gacatctata ttcactgggt gaagcagagg      120

cctgaacagg gcctggagtg gattgggagg attgatcctg cgaacggtaa gactgcatat      180

gacctgaagt tccaggccaa ggccactata acagcagaca catcttccaa aacagcctac      240

ctgcacctca gcagcctgac atctgaggac actgccgtct attactgtgg taggggggcc      300

cactggggcc aaggcaccac tctcacagtc tcctca                                336


<210>  170
<211>  112
<212>  PRT
<213>  С

<400>  170

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Thr Ser Gly Leu Asn Ile Lys Asp Ile 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Lys Thr Ala Tyr Asp Leu Lys Phe 
    50                  55                  60                  


Gln Ala Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Lys Thr Ala Tyr 
65                  70                  75                  80  


Leu His Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Gly Ala His Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


<210>  171
<211>  354
<212>  DNA
<213>  С

<400>  171
cagatccagt tggtgcagtc tgggcctcag ctggttaggc ctggggcttc agtgaagata       60

tcctgcgagg cttctggtta ctcattcacc aactactgga tacactgggt gaagcagagg      120

cctggacagg gtcttgagtg gattggcatg attgatcctt ccgatgctga aactgggtta      180

aatcagaagt tcaaggacaa ggccacattg actgtagaca aatcctccag cacagcctac      240

atgcaactca gcagcccgac atctgaagac tctgcggtct attactgtgc aagaattggc      300

gattactata atatggacta ctggggtcaa ggaacctcag tcaccgtctc ctca            354


<210>  172
<211>  118
<212>  PRT
<213>  С

<400>  172

Gln Ile Gln Leu Val Gln Ser Gly Pro Gln Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Glu Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ala Glu Thr Gly Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Gly Asp Tyr Tyr Asn Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  173
<211>  366
<212>  DNA
<213>  С

<400>  173
gaagtgaagg tggtggagtc tgggggaggt ttagtgcagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt gactatccca tgtcttgggt tcgccagact      120

ccagagaaga gactggagtg ggtcgcatac gttagtgatg gtggtggttc cacctactat      180

ccagacattg taaagggccg attcaccatc tcccgagaca atgccaagaa caccctgtac      240

cttcaaatga gcagtctgaa gtctgaggac acggccatgt atttctgtac aagacatgct      300

tcctactata gctacgacca ttctatggac tactggggtc agggaacctc agtcaccgtc      360

tcatca                                                                 366


<210>  174
<211>  122
<212>  PRT
<213>  С

<400>  174

Glu Val Lys Val Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Val Ser Asp Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Ile Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Phe Cys 
                85                  90                  95      


Thr Arg His Ala Ser Tyr Tyr Ser Tyr Asp His Ser Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  175
<211>  357
<212>  DNA
<213>  С

<400>  175
cagatccagt tggtgcagtc tgggggagac ttagtgaggc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctttggca tgtcttggat tcgccagact      120

ccagacaaga ggctggagtg ggtcgcaacc attagtagtg ctggtagttt cacctactat      180

ccagacagtg tgaagggccg attcaccatc tccagagaca atgccaggaa caccctgtat      240

ctacaaatga acagtctgaa gtctgaggac tcagccatgt attactgtgc aagacggggg      300

tacgacgttg ggtgctttga ccactggggc cgaggcacca ctctcacagt ctcctca         357


<210>  176
<211>  119
<212>  PRT
<213>  С

<400>  176

Gln Ile Gln Leu Val Gln Ser Gly Gly Asp Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Ile Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Ala Gly Ser Phe Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Tyr Asp Val Gly Cys Phe Asp His Trp Gly Arg Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  177
<211>  348
<212>  DNA
<213>  С

<400>  177
gaggtgcacc tggtggagtc tgggggaggc ttagtgcagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt acctatggca tgtcttgggt tcgccagact      120

ccagacaaga ggctggagtt ggtcgcgacc attaatacta atggtggtac cacctattat      180

cgagacagtg tgaagggccg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgatgac acagccatgt attactgtgc aagagactac      300

ggggctatgg actactgggg tcaaggaacc tcagtcaccg tctcctca                   348


<210>  178
<211>  116
<212>  PRT
<213>  С

<400>  178

Glu Val His Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Asn Thr Asn Gly Gly Thr Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  179
<211>  345
<212>  DNA
<213>  С

<400>  179
gatgtgcacc tggtggagtc tgggggaggc ttagtgcagc ctggagggtc cctgacagtc       60

tcctgcgcag cctctggatt cactttcagt acctatggca tgtcttgggt tcgccagact      120

cgagacaaga ggctggagtt ggtcgcaacc ataaatacta atggtggtaa cacctattat      180

tcagacaatg tgaagggccg attcaccatt tccagagaca atgccaagaa caccctgtat      240

ttggaaatga gaggtctgag gtctggggac acagccatgt attactgtgc aagagactac      300

ggggctatgg actactgggg tcaaggaacc tcagtcaccg tctct                      345


<210>  180
<211>  115
<212>  PRT
<213>  С

<400>  180

Asp Val His Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Arg Asp Lys Arg Leu Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Asn Thr Asn Gly Gly Asn Thr Tyr Tyr Ser Asp Asn Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Arg Gly Leu Arg Ser Gly Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser 
        115 


<210>  181
<211>  348
<212>  DNA
<213>  С

<400>  181
gaggtgcagc tgcagcagcc tgggggaggc ttagtacagc ctggagggtc cctgacactc       60

tcctgtgcaa cctctggatt cactttcagt agttatggca tgtcttgggt tcgccagact      120

ccagccaaga ggctggagtt ggtcgcaacc attagtacta atggtgccac cgccaattat      180

ccagacagtg tgaagggccg attcaccatc tccagagaca atgccaagag caccctgtac      240

ctacaaatgc gcagtctgaa gtctgaggac acagccatgt attactgtgc aactgaaaag      300

ggagctatgg gctactgggg tcaaggaacc tcagtcaccg tctcctca                   348


<210>  182
<211>  116
<212>  PRT
<213>  С

<400>  182

Glu Val Gln Leu Gln Gln Pro Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Ala Lys Arg Leu Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Ser Thr Asn Gly Ala Thr Ala Asn Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Arg Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Glu Lys Gly Ala Met Gly Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  183
<211>  381
<212>  DNA
<213>  С

<400>  183
caagttactc taaaagagtc tggccctggg atattgaagc cctcacagac cctcagtctg       60

acttgttctt tctctgggtt ttcactgacc acttctggta tgggtgtagg ctggattcgt      120

cagccttcag ggaagggtct ggagtggctg gcacacattt ggtgggatga tgataagtac      180

tataatccat ccctgaagag ccaggtcaca atctccaagg acacctccag aaaccaggta      240

ttcctcaaga tcaccagtgt ggacactgca gatactgcca cttactactg tgctcgaaga      300

actgagacta tgattacgac agtgctatat tactatgcta tggactactg gggtcaagga      360

acctcagtca ccgtctcctc a                                                381


<210>  184
<211>  127
<212>  PRT
<213>  С

<400>  184

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Thr Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Gln Val Thr Ile Ser Lys Asp Thr Ser Arg Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Thr Glu Thr Met Ile Thr Thr Val Leu Tyr Tyr Tyr 
            100                 105                 110         


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125         


<210>  185
<211>  378
<212>  DNA
<213>  С

<400>  185
caagttactc taaaagagtc tggccctggg atattgaagc cctcacagac cctcagtctg       60

acttgttctt tctctggatt ttcactgagc acttctggtt tgggtgtagg ctggattcgt      120

cagccttcag ggaagggtct ggagtggctg gcacacattt ggtgggatga tgataagtac      180

tataatccat cccttaagag acagatcaca atctccaagg attcctccag aaaccaggta      240

ttcctcaaga tcaccaatgt ggacactgca gatactgcca cttactactg tgctcgaagg      300

agggaagtta acttcggtat taactattac tattctatgg actactgggg tcaaggaacc      360

tcagtcaccg tctcctca                                                    378


<210>  186
<211>  126
<212>  PRT
<213>  С

<400>  186

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Leu Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Arg Gln Ile Thr Ile Ser Lys Asp Ser Ser Arg Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Arg Glu Val Asn Phe Gly Ile Asn Tyr Tyr Tyr Ser 
            100                 105                 110         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125     


<210>  187
<211>  363
<212>  DNA
<213>  С

<400>  187
gaggtgaagc tggtggagtc tggaggacgc ttggtacagc ctgggaattc tctgagactc       60

tcctgtgcaa cttctggatt caccttcagt gattattaca tgagttgggt ccgccagact      120

ccaggaaggg cacttgagtg gttgagtttt attagaaatc gggctaatgg ttacacaaca      180

gagtacagtg catctgtgaa gggtcgattc accatctcca gagataattc ccaaagcatc      240

ctctatcttc acatgagcac cctgagacct gaggacagtg ccacttatta ctgtgtaaga      300

gattcctatc actacgggta cttcgatgtc tggggcgcag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  188
<211>  121
<212>  PRT
<213>  С

<400>  188

Glu Val Lys Leu Val Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Thr Pro Gly Arg Ala Leu Glu Trp Leu 
        35                  40                  45              


Ser Phe Ile Arg Asn Arg Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu His Met Ser Thr Leu Arg Pro Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Val Arg Asp Ser Tyr His Tyr Gly Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  189
<211>  360
<212>  DNA
<213>  

<400>  189
caggtgaccc tgaaggaatc cgggcctact ctggtgaaac ctacccagac tctgactctg       60

acttgtactt ttagcggctt ctcactgacc acatctggac tgggagtggc ttggatcaga      120

cagcctcctg gaaaggccct ggagtggctg gctcacattt ggagcgacgg cgatactcgg      180

tactatccag ccctgaaaaa cagactgact atcaccaagg acacatccaa aaaccaggtg      240

gtcctgacaa tgactaatat ggaccccgtc gataccgcaa catactattg cgcccatatg      300

aaggatgact ctctgtactt tgataactgg gggcagggaa ctctggtgac cgtgagcagc      360


<210>  190
<211>  120
<212>  PRT
<213>  

<400>  190

Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 
            20                  25                  30          


Gly Leu Gly Val Ala Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Ser Asp Gly Asp Thr Arg Tyr Tyr Pro Ala 
    50                  55                  60                  


Leu Lys Asn Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Met Lys Asp Asp Ser Leu Tyr Phe Asp Asn Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  191
<211>  348
<212>  DNA
<213>  

<400>  191
gaggtgcagc tgctggaatc tgggggggga ctggtgcagc ctggaggaag cctgagactg       60

agttgtgccg caagtgggtt tacatttagc tcctacggaa tgagctgggt gaggcaggct      120

ccaggcaagg gactggagtg ggtctctgca atcagtacca acggagccac agcttactat      180

gccgactccg tgaagggccg gttcactatc tcaagagata acagcaagaa caccctgtat      240

ctgcagatga attctctgcg ggcagaagac acagccgtct actattgcgc tactgagaaa      300

ggggcaatga gccactgggg acagggcaca ctggtgaccg tgagttcc                   348


<210>  192
<211>  116
<212>  PRT
<213>  

<400>  192

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Thr Asn Gly Ala Thr Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Glu Lys Gly Ala Met Ser His Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     



<210>  193
<211>  318
<212>  DNA
<213>  

<400>  193
accgtggccg ccccctccgt gttcatcttc cccccctccg acgagcagct gaagtccggc       60

accgcctccg tggtgtgcct gctgaacaac ttctacccca gggaggccaa ggtgcagtgg      120

aaggtggaca acgccctgca gtccggcaac tcccaggagt ccgtgaccga gcaggactcc      180

aaggactcca cctactccct gtcctccacc ctgaccctgt ccaaggccga ctacgagaag      240

cacaaggtgt acgcctgcga ggtgacccac cagggcctgt cctcccccgt gaccaagtcc      300

ttcaacaggg gcgagtgc                                                    318


<210>  194
<211>  106
<212>  PRT
<213>  

<400>  194

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210> 195
<211>  318
<212>  DNA
<213>  

<400>  195
ggacagccaa aggcagcacc atctgtgacc ctgttcccac ctagctccga ggagctgcag       60

gccaacaagg ccaccctggt gtgcctgatc tccgactttt acccaggagc agtgacagtg      120

gcatggaagg ccgattctag ccctgtgaag gccggcgtgg agaccacaac cccatctaag      180

cagagcaaca ataagtacgc cgcctcctct tatctgtccc tgacccccga gcagtggaag      240

tctcaccgga gctattcctg ccaggtgaca cacgagggca gcacagtgga gaagaccgtg      300

gcccctacag agtgttcc                                                    318


<210>  196
<211>  106
<212>  PRT
<213>  

<400>  196

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  197
<211>  978
<212>  DNA
<213>  

<400>  197
gcctccacca agggcccctc cgtgttcccc ctggccccct gctccaggtc cacctccgag       60

tccaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc      120

tggaactccg gcgccctgac ctccggcgtg cacaccttcc ccgccgtgct gcagtcctcc      180

ggcctgtact ccctgtcctc cgtggtgacc gtgccctcct cctccctggg caccaagacc      240

tacacctgca acgtggacca caagccctcc aacaccaagg tggacaagag ggtggagtcc      300

aagtacggcc ccccctgccc cccctgcccc gcccccgagg ccgccggcgg cccctccgtg      360

ttcctgttcc cccccaagcc caaggacacc ctgatgatct ccaggacccc cgaggtgacc      420

tgcgtggtgg tggacgtgtc ccaggaggac cccgaggtgc agttcaactg gtacgtggac      480

ggcgtggagg tgcacaacgc caagaccaag cccagggagg agcagttcaa ctccacctac      540

agggtggtgt ccgtgctgac cgtgctgcac caggactggc tgaacggcaa ggagtacaag      600

tgcaaggtgt ccaacaaggg cctgccctcc tccatcgaga agaccatctc caaggccaag      660

ggccagccca gggagcccca ggtgtacacc ctgcccccct cccaggagga gatgaccaag      720

aaccaggtgt ccctgacctg cctggtgaag ggcttctacc cctccgacat cgccgtggag      780

tgggagtcca acggccagcc cgagaacaac tacaagacca ccccccccgt gctggactcc      840

gacggctcct tcttcctgta ctccaggctg accgtggaca agtccaggtg gcaggagggc      900

aacgtgttct cctgctccgt gatgcacgag gccctgcaca accactacac ccagaagtcc      960

ctgtccctgt ccctgggc                                                    978


<210>  198
<211>  326
<212>  PRT
<213>  

<400>  198

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly 
                325  


<210>  199
<211>  20
<212>  DNA
<213>  ˹

<220>
<223>  ϳɹ

<400>  199
tttggrggga agatgaagac                                                   20


<210>  200
<211>  21
<212>  DNA
<213>  ˹

<220>
<223>  ϳɹ

<400>  200
ttaacactct cccctgttga a                                                 21


<210>  201
<211>  21
<212>  DNA
<213>  ˹

<220>
<223>  ϳɹ

<400>  201
ttaacactca ttcctgttga a                                                 21


<210>  202
<211>  21
<212>  DNA
<213>  ˹

<220>
<223>  ϳɹ

<400>  202
tggacaggga tccagagttc c                                                 21


<210>  203
<211>  21
<212>  DNA
<213>  ˹

<220>
<223>  ϳɹ

<400>  203
tggacagggc tccatagttc c                                                 21


<210>  204
<211>  20
<212>  DNA
<213>  ˹

<220>
<223>  ϳɹ

<400>  204
actcgtcctt ggtcaacgtg                                                   20

   
<210>  205
<211>  9
<212>  PRT
<213>  С

<400>  205
Gln His Ser Tyr Ser Trp Pro Trp Thr 
1               5     


<210>  206
<211>  326
<212>  PRT
<213>  

<400>  206

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  207
<211>  137
<212>  PRT
<213>  

<400>  207

Gly Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
1               5                   10                  15      


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
            20                  25                  30          


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
        35                  40                  45              


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
    50                  55                  60                  


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
65                  70                  75                  80  


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
                85                  90                  95      


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
            100                 105                 110         


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
        115                 120                 125             


Glu Glu Tyr Asn Thr Ser Asn Pro Asp 
    130                 135         


<210>  208
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  ϳɹ

<400>  208

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  


<210>  209
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  ϳɹ

<400>  209

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15     


<210>  210
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  ϳɹ

<400>  210

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20                


<210>  211
<211>  214
<212>  PRT
<213>  

<400>  211

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Lys Pro Asp Gln Tyr Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Lys Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Tyr Ser Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  212
<211>  603
<212>  PRT
<213>  ˹

<220>
<223>  ϳɹ

<400>  212

Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Ser 
            20                  25                  30          


Gly Leu Gly Val Ala Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Ser Asp Gly Asp Thr Arg Tyr Tyr Pro Ala 
    50                  55                  60                  


Leu Lys Asn Arg Leu Thr Ile Thr Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Met Lys Asp Asp Ser Leu Tyr Phe Asp Asn Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 


Gly Ser Gly Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met 
465                 470                 475                 480 


Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys 
                485                 490                 495     


Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met 
            500                 505                 510         


Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys 
        515                 520                 525             


Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val 
    530                 535                 540                 


Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala 
545                 550                 555                 560 


Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr 
                565                 570                 575     


Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile 
            580                 585                 590         


Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp 
        595                 600             