                         SEQUENCE LISTING

<110>  Peking University
 
<120>  TARGETED RNA EDITING BY LEVERAGING ENDOGENOUS ADAR USING 
       ENGINEERED RNAS

<130>  FD00254PCT

<150>  PCT/CN2019/095802
<151>  2019-07-12

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  122
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  1
aagattgtgt gtggatcgat gatgacttcc atatatacat tccttggaaa gctgaacaaa       60

atgagtgaaa actctatacc gtcattctcg tcgaactgag gtccagcaca ttactccaac      120

ag                                                                     122


<210>  2
<211>  116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  2
gagtgagatc ttggaccaat gatgacttcc atacatgcat tccttggaaa gctgaacaaa       60

atgagtggga actctgtact atcatcttag ttgaactgag gtccaccggg ggctaa          116


<210>  3
<211>  508
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  3
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      360

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      420

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      480

acggtgggag gtctatataa gcagagct                                         508


<210>  4
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  4
gggagcagcc ucuggcauuc ugggagcuuc aucuggaccu gggucuucag ugaaccauug       60

uucaauaucg uccggggaca gcaucaaauc auccauugcu ugggacggca a               111


<210>  5
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  5
gacgcccacc gugugguugc uguccaggac ggucccggcc ugcgacacuu cggcccagag       60

cugcuccuca ucugcggggc gggggggggc cgucgccgcg uggggucguu g               111


<210>  6
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  6
cauauuacag aauaccuuga uagcauccaa uuugcauccu ugguuagggu caacccagua       60

uucuccacuc uugaguucag gauggcagaa uuucaggucu cugcaguuuc u               111


<210>  7
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  7
gugaagauaa gccaguccuc uaguaacaga augagcaaga cggcaagagc uuacccaguc       60

acuugugugg agacuuaaau acuugcauaa agauccauug ggauaguacu c               111


<210>  8
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  8
gugaacguca aacugucgga ccaauauggc agaaucuucu cucaucucaa cuuuccauau       60

ccguaucaug gaaucauagc auccuguaac uacuagcucu cuuacagcug g               111


<210>  9
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  9
gccaaugauc ucgugaguua ucucagcagu gugagccauc agggugauga caucccaggc       60

gaucgugugg ccuccaggag cccagagcag gaaguugagg agaaggugcc u               111


<210>  10
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  10
caagacggug aaccacucca uggucuucuu gucggcuuuc ugcacugugu acccccagag       60

cuccguguug ccgacauccu gggguggcuu ccacuccaga gccacauuaa g               111


<210>  11
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  11
aggauucucu uuugaaguau ugcuccccca guggauuggg uggcuccauu cacuccaaug       60

cugagcacuu ccacagagug gguuaaagcg gcuccgaaca cgaaacgugu a               111


<210>  12
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  12
tataactagt atggtgagca agggcgagga g                                      31


<210>  13
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  13
tatacgtctc atctacagat tcttccggcg tgtatacctt c                           41


<210>  14
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  14
tatacgtctc atagagatcc ccggtcgcca ccgtgagcaa gggcgaggag ctg              53


<210>  15
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  15
uaaaccgagg gaucauaggg gacugaaucc accauucuuc ucccaauccc u                51


<210>  16
<211>  151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  16
acuacaguug cuccgauauu uaggcuacgu caauaggcac uaacuuauug gcgcugguga       60

acggacuucc ucucgaguac cagaagauga cuacaaaacu ccuuuccauu gcgaguaucg      120

gagucuggcu caguuuggcc agggaggcac u                                     151


<210>  17
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  17
gcccttgctc actggcagag ccctccagca tcgcgagcag gcgctgcctc c                51


<210>  18
<211>  151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  18
acuacaguug cuccgauauu uaggcuacgu caauaggcac uaacuuauug gcgcugguga       60

acggacuucc ucucgaguac cagaagauga cuacaaaacu ccuuuccauu gcgaguaucg      120

gagucuggcu caguuuggcc agggaggcac u                                     151


<210>  19
<211>  116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  19
gagtgagatc ttggaccaat gatgacttcc atacatgcat tccttggaaa gctgaacaaa       60

atgagtggga actctgtact atcatcttag ttgaactgag gtccaccggg ggctaa          116


<210>  20
<211>  122
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  20
aagattgtgt gtggatcgat gatgacttcc atatatacat tccttggaaa gctgaacaaa       60

atgagtgaaa actctatacc gtcattctcg tcgaactgag gtccagcaca ttactccaac      120

ag                                                                     122


<210>  21
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  21
atggtgagca agggcgagga ggataacatg gccatcatca aggagttcat gcgcttcaag       60

gtgcacatgg agggctccgt gaacggccac gagttcgaga tcgagggcga gggcgagggc      120

cgcccctacg agggcaccca gaccgccaag ctgaaggtga ccaagggtgg ccccctgccc      180

ttcgcctggg acatcctgtc ccctcagttc atgtacggct ccaaggccta cgtgaagcac      240

cccgccgaca tccccgacta cttgaagctg tccttccccg agggcttcaa gtgggagcgc      300

gtgatgaact tcgaggacgg cggcgtggtg accgtgaccc aggactcctc cctgcaggac      360

ggcgagttca tctacaaggt gaagctgcgc ggcaccaact tcccctccga cggccccgta      420

atgcagaaga agaccatggg ctgggaggcc tcctccgagc ggatgtaccc cgaggacggc      480

gccctgaagg gcgagatcaa gcagaggctg aagctgaagg acggcggcca ctacgacgct      540

gaggtcaaga ccacctacaa ggccaagaag cccgtgcagc tgcccggcgc ctacaacgtc      600

aacatcaagt tggacatcac ctcccacaac gaggactaca ccatcgtgga acagtacgaa      660

cgcgccgagg gccgccactc caccggcggc atggacgagc tgtacaag                   708


<210>  22
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  22
ctgcagggcg gaggaggcag cggcggagga ggcagcggcg gaggaggcag cagaaggtat       60

acacgccgga agaatctgta gagatccccg gtcgccacc                              99


<210>  23
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  23
gtgagcaagg gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc       60

gacgtaaacg gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc      120

aagctgaccc tgaagttcat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc      180

gtgaccaccc tgacctacgg cgtgcagtgc ttcagccgct accccgacca catgaagcag      240

cacgacttct tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc      300

aaggacgacg gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga caccctggtg      360

aaccgcatcg agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag      420

ctggagtaca actacaacag ccacaacgtc tatatcatgg ccgacaagca gaagaacggc      480

atcaaggtga acttcaagat ccgccacaac atcgaggacg gcagcgtgca gctcgccgac      540

cactaccagc agaacacccc catcggcgac ggccccgtgc tgctgcccga caaccactac      600

ctgagcaccc agtccgccct gagcaaagac cccaacgaga agcgcgatca catggtcctg      660

ctggagttcg tgaccgccgc cgggatcact ctcggcatgg acgagctgta caagtaa         717


<210>  24
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  24
ctgcagggcg gaggaggcag cgcctgctcg cgatgctaga gggctctgcc a                51


<210>  25
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  25
aaccaugccg acugauggca g                                                 21


<210>  26
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  26
cugccaucag ucggcgugga cuguag                                            26


<210>  27
<211>  71
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  27
acagcuccuc gcccuugcuc acuggcagag cccuccagca ucgcgagcag gcgcugccuc       60

cuccgccgcu g                                                            71


<210>  28
<211>  121
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  28
cacacacaaa cacacacaac acaacacagc uccucgcccu ugcucacugg cagagcccuc       60

cagcaucgcg agcaggcgcu gccuccuccg ccgcugcaac acacaaaacc accacaccaa      120

c                                                                      121


<210>  29
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  29
accacacaca caaccaccac acacacacac acaaacacac acaacacaac acagcuccuc       60

gcccuugcuc acuggcagag cccuccagca ucgcgagcag gcgcugccuc cuccgccgcu      120

gcaacacaca aaaccaccac accaacccca acaaccacac acccacacaa c               171


<210>  30
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  30
gaugggcacc accccgguga acagcuccuc gcccuugcuc acuggcagag cccuccagca       60

ucgcgagcag gcgcugccuc cuccgccgcu gccuccuccg ccgcugccuc c               111


<210>  31
<211>  161
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  31
cacacacaaa cacacacaac acaacgaugg gcaccacccc ggugaacagc uccucgcccu       60

ugcucacugg cagagcccuc cagcaucgcg agcaggcgcu gccuccuccg ccgcugccuc      120

cuccgccgcu gccucccaac acacaaaacc accacaccaa c                          161


<210>  32
<211>  211
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  32
accacacaca caaccaccac acacacacac acaaacacac acaacacaac gaugggcacc       60

accccgguga acagcuccuc gcccuugcuc acuggcagag cccuccagca ucgcgagcag      120

gcgcugccuc cuccgccgcu gccuccuccg ccgcugccuc ccaacacaca aaaccaccac      180

accaacccca acaaccacac acccacacaa c                                     211


<210>  33
<211>  123
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  33
uugccaugug uaugugggga gacggucggg uccagauauu cguaucuguc gaguagagug       60

ugggcucccc acauacucug augauccaga gacgauauua cgucucagga ucauucaugg      120

caa                                                                    123


<210>  34
<211>  71
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  34
acagcuccuc gcccuugcuc acuggcagag cccuccagca ucgcgagcag gcgcugccuc       60

cuccgccgcu g                                                            71


<210>  35
<211>  71
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  35
uuucagcuau accugcccgg uauaaaggga cguucacacc gcgauguucu cugcugggga       60

auugcgcgau a                                                            71


<210>  36
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  36
gaugggcacc accccgguga acagcuccuc gcccuugcuc acuggcagag cccuccagca       60

ucgcgagcag gcgcugccuc cuccgccgcu gccuccuccg ccgcugccuc c               111


<210>  37
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  37
uaccgcuaca gccacgcuga uuucagcuau accugcccgg uauaaaggga cguucacacc       60

gcgauguucu cugcugggga auugcgcgau auucaggauu aaaagaagug c               111


<210>  38
<211>  151
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  38
acuacaguug cuccgauauu uaggcuacgu caauaggcac uaacuuauug gcgcugguga       60

acggacuucc ucucgaguac cagaagauga cuacaaaacu ccuuuccauu gcgaguaucg      120

gagucuggcu caguuuggcc agggaggcac u                                     151


<210>  39
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  39
acuggcagag cccuccagca ucgcgagcag g                                      31


<210>  40
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  40
gcccuugcuc acuggcagag cccuccagca ucgcgagcag gcgcugccuc c                51


<210>  41
<211>  71
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  41
acagcuccuc gcccuugcuc acuggcagag cccuccagca ucgcgagcag gcgcugccuc       60

cuccgcccug c                                                            71


<210>  42
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  42
accccgguga acagcuccuc gcccuugcuc acuggcagag cccuccagca ucgcgagcag       60

gcgcugccuc cuccgcccug cagcuuguac a                                      91


<210>  43
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  43
gaugggcacc accccgguga acagcuccuc gcccuugcuc acuggcagag cccuccagca       60

ucgcgagcag gcgcugccuc cuccgcccug cagcuuguac agcucgucca u               111


<210>  44
<211>  131
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  44
gcucgaccag gaugggcacc accccgguga acagcuccuc gcccuugcuc acuggcagag       60

cccuccagca ucgcgagcag gcgcugccuc cuccgcccug cagcuuguac agcucgucca      120

ugccgccggu g                                                           131


<210>  45
<211>  151
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  45
ucgccgucca gcucgaccag gaugggcacc accccgguga acagcuccuc gcccuugcuc       60

acuggcagag cccuccagca ucgcgagcag gcgcugccuc cuccgcccug cagcuuguac      120

agcucgucca ugccgccggu ggaguggcgg c                                     151


<210>  46
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  46
gaugggcacc accccgguga acagcuccuc gcccuugcuc acuggcagag cccuccagca       60

ucgcgagcag gcgcugccuc cuccgccgcu gccuccuccg ccgcugccuc c               111


<210>  47
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  47
uaccgcuaca gccacgcuga uuucagcuau accugcccgg uauaaaggga cguucacacc       60

gcgauguucu cugcugggga auugcgcgau auucaggauu aaaagaagug c               111


<210>  48
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  48
gaugggcacc accccgguga acagcuccuc gcccuugcuc acuggcagag cccuccagca       60

ucgcgagcag gcgcugccuc cuccgccgcu gccuccuccg ccgcugccuc c               111


<210>  49
<211>  111
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  49
uaccgcuaca gccacgcuga uuucagcuau accugcccgg uauaaaggga cguucacacc       60

gcgauguucu cugcugggga auugcgcgau auucaggauu aaaagaagug c               111


<210>  50
<211>  74
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  50
gcagcggcgg aggaggcagc gccugcucgc gaugcuagag ggcucugcca gugagcaagg       60

gcgaggagcu guuc                                                         74


<210>  51
<211>  87
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized sequence

<400>  51
gagcuguaca agcugcaggg cggaggaggc agcgccugcu cgcgaugcua gagggcucug       60

ccagugagca agggcgagga gcuguuc                                           87


