﻿                         序列表

<110>  北京科诺科服生物科技有限公司

<120>  一种用于治疗动物肿瘤的融合蛋白及组合物

<160>  6

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  817
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  SIGNAL
<222>  (1)..(817)
<223>  融合蛋白


<400>  1
Ile Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Leu Asp Trp His 
1               5                   10                  15      
Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys His Thr Pro Glu 
            20                  25                  30          
Glu Asp Asp Ile Thr Trp Thr Ser Ala Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              
Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  
Gln Tyr Thr Cys His Lys Gly Gly Lys Val Leu Ser Arg Ser Leu Leu 
65                  70                  75                  80  
Leu Ile His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      
Glu Gln Lys Glu Ser Lys Asn Lys Ile Phe Leu Lys Cys Glu Ala Lys 
            100                 105                 110         
Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Ala Ile Ser Thr 
        115                 120                 125             
Asp Leu Lys Phe Ser Val Lys Ser Ser Arg Gly Phe Ser Asp Pro Gln 
    130                 135                 140                 
Gly Val Thr Cys Gly Ala Val Thr Leu Ser Ala Glu Arg Val Arg Val 
145                 150                 155                 160 
Asp Asn Arg Asp Tyr Lys Lys Tyr Thr Val Glu Cys Gln Glu Gly Ser 
                165                 170                 175     
Ala Cys Pro Ser Ala Glu Glu Ser Leu Pro Ile Glu Val Val Val Asp 
            180                 185                 190         
Ala Ile His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile 
        195                 200                 205             
Arg Asp Ile Ile Lys Pro Asp Pro Pro Thr Asn Leu Gln Leu Lys Pro 
    210                 215                 220                 
Leu Lys Asn Ser Arg His Val Glu Val Ser Trp Glu Tyr Pro Asp Thr 
225                 230                 235                 240 
Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Ala 
                245                 250                 255     
Gln Gly Lys Asn Asn Arg Glu Lys Lys Asp Arg Leu Cys Val Asp Lys 
            260                 265                 270         
Thr Ser Ala Lys Val Val Cys His Lys Asp Ala Lys Ile Arg Val Gln 
        275                 280                 285             
Ala Arg Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Asp Trp Ala Ser Val 
    290                 295                 300                 
Ser Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
305                 310                 315                 320 
Gly Ser Arg Ser Leu Pro Thr Ala Ser Pro Ser Pro Gly Ile Phe Gln 
                325                 330                 335     
Cys Leu Asn His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Thr Leu 
            340                 345                 350         
Gln Lys Ala Arg Gln Thr Leu Glu Leu Tyr Ser Cys Thr Ser Glu Glu 
        355                 360                 365             
Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala 
    370                 375                 380                 
Cys Leu Pro Leu Glu Leu Thr Met Asn Glu Ser Cys Leu Ala Ser Arg 
385                 390                 395                 400 
Glu Ile Ser Leu Ile Thr Asn Gly Ser Cys Leu Ala Ser Gly Lys Ala 
                405                 410                 415     
Ser Phe Met Thr Val Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys 
            420                 425                 430         
Met Tyr Gln Met Glu Phe Lys Ala Met Asn Ala Lys Leu Leu Met Asp 
        435                 440                 445             
Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Thr Ala Ile Asp 
    450                 455                 460                 
Glu Leu Leu Gln Ala Leu Asn Phe Asn Ser Val Thr Val Pro Gln Lys 
465                 470                 475                 480 
Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys 
                485                 490                 495     
Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Met 
            500                 505                 510         
Met Ser Tyr Leu Asn Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        515                 520                 525             
Ser Gly Gly Gly Gly Ser Ala Pro Ile Thr Ser Ser Ser Thr Lys Glu 
    530                 535                 540                 
Thr Glu Gln Gln Met Glu Gln Leu Leu Leu Asp Leu Gln Leu Leu Leu 
545                 550                 555                 560 
Asn Gly Val Asn Asn Tyr Glu Asn Pro Gln Leu Ser Arg Met Leu Thr 
                565                 570                 575     
Phe Lys Phe Tyr Thr Pro Lys Lys Ala Thr Glu Phe Thr His Leu Gln 
            580                 585                 590         
Cys Leu Ala Glu Glu Leu Lys Asn Leu Glu Glu Val Leu Gly Leu Pro 
        595                 600                 605             
Gln Ser Lys Asn Val His Leu Thr Asp Thr Lys Glu Leu Ile Ser Asn 
    610                 615                 620                 
Met Asn Val Thr Leu Leu Lys Leu Lys Gly Ser Glu Thr Ser Tyr Asn 
625                 630                 635                 640 
Cys Glu Tyr Asp Asp Glu Thr Ala Thr Ile Thr Glu Phe Leu Asn Lys 
                645                 650                 655     
Trp Ile Thr Phe Cys Gln Ser Ile Phe Ser Thr Leu Thr Gly Gly Gly 
            660                 665                 670         
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Arg 
        675                 680                 685             
Ser Pro Thr Leu Val Thr Arg Pro Ser Gln His Val Asp Ala Ile Gln 
    690                 695                 700                 
Glu Ala Leu Ser Leu Leu Asn Asn Ser Asn Asp Val Thr Ala Val Met 
705                 710                 715                 720 
Asn Lys Ala Val Lys Val Val Ser Glu Val Phe Asp Pro Glu Gly Pro 
                725                 730                 735     
Thr Cys Leu Glu Thr Arg Leu Gln Leu Tyr Lys Glu Gly Leu Gln Gly 
            740                 745                 750         
Ser Leu Thr Ser Leu Lys Asn Pro Leu Thr Met Met Ala Asn His Tyr 
        755                 760                 765             
Lys Gln His Cys Pro Pro Thr Pro Glu Ser Pro Cys Ala Thr Gln Asn 
    770                 775                 780                 
Ile Asn Phe Lys Ser Phe Lys Glu Asn Leu Lys Asp Phe Leu Phe Asn 
785                 790                 795                 800 
Ile Pro Phe Asp Cys Trp Lys Pro Val Lys Lys His His His His His 
                805                 810                 815     
His 
    

<210>  2
<211>  817
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  SIGNAL
<222>  (1)..(817)
<223>  融合蛋白


<400>  2
Ile Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Leu Asp Trp His 
1               5                   10                  15      
Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys His Thr Pro Glu 
            20                  25                  30          
Glu Asp Asp Ile Thr Trp Thr Ser Ala Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              
Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  
Gln Tyr Thr Cys His Lys Gly Gly Lys Val Leu Ser Arg Ser Leu Leu 
65                  70                  75                  80  
Leu Ile His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      
Glu Gln Lys Glu Ser Lys Asn Lys Ile Phe Leu Lys Cys Glu Ala Lys 
            100                 105                 110         
Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Ala Ile Ser Thr 
        115                 120                 125             
Asp Leu Lys Phe Ser Val Lys Ser Ser Arg Gly Phe Ser Asp Pro Gln 
    130                 135                 140                 
Gly Val Thr Cys Gly Ala Val Thr Leu Ser Ala Glu Arg Val Arg Val 
145                 150                 155                 160 
Asp Asn Arg Asp Tyr Lys Lys Tyr Thr Val Glu Cys Gln Glu Gly Ser 
                165                 170                 175     
Ala Cys Pro Ser Ala Glu Glu Ser Leu Pro Ile Glu Val Val Val Asp 
            180                 185                 190         
Ala Ile His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile 
        195                 200                 205             
Arg Asp Ile Ile Lys Pro Asp Pro Pro Thr Asn Leu Gln Leu Lys Pro 
    210                 215                 220                 
Leu Lys Asn Ser Arg His Val Glu Val Ser Trp Glu Tyr Pro Asp Thr 
225                 230                 235                 240 
Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Ala 
                245                 250                 255     
Gln Gly Lys Asn Asn Arg Glu Lys Lys Asp Arg Leu Cys Val Asp Lys 
            260                 265                 270         
Thr Ser Ala Lys Val Val Cys His Lys Asp Ala Lys Ile Arg Val Gln 
        275                 280                 285             
Ala Arg Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Asp Trp Ala Ser Val 
    290                 295                 300                 
Ser Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
305                 310                 315                 320 
Gly Ser Arg Ser Leu Pro Thr Ala Ser Pro Ser Pro Gly Ile Phe Gln 
                325                 330                 335     
Cys Leu Asn His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Thr Leu 
            340                 345                 350         
Gln Lys Ala Arg Gln Thr Leu Glu Leu Tyr Ser Cys Thr Ser Glu Glu 
        355                 360                 365             
Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala 
    370                 375                 380                 
Cys Leu Pro Leu Glu Leu Thr Met Asn Glu Ser Cys Leu Ala Ser Arg 
385                 390                 395                 400 
Glu Ile Ser Leu Ile Thr Asn Gly Ser Cys Leu Ala Ser Gly Lys Ala 
                405                 410                 415     
Ser Phe Met Thr Val Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys 
            420                 425                 430         
Met Tyr Gln Met Glu Phe Lys Ala Met Asn Ala Lys Leu Leu Met Asp 
        435                 440                 445             
Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Thr Ala Ile Asp 
    450                 455                 460                 
Glu Leu Leu Gln Ala Leu Asn Phe Asn Ser Val Thr Val Pro Gln Lys 
465                 470                 475                 480 
Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys 
                485                 490                 495     
Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Met 
            500                 505                 510         
Met Ser Tyr Leu Asn Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        515                 520                 525             
Ser Gly Gly Gly Gly Ser Ala Pro Thr Arg Ser Pro Thr Leu Val Thr 
    530                 535                 540                 
Arg Pro Ser Gln His Val Asp Ala Ile Gln Glu Ala Leu Ser Leu Leu 
545                 550                 555                 560 
Asn Asn Ser Asn Asp Val Thr Ala Val Met Asn Lys Ala Val Lys Val 
                565                 570                 575     
Val Ser Glu Val Phe Asp Pro Glu Gly Pro Thr Cys Leu Glu Thr Arg 
            580                 585                 590         
Leu Gln Leu Tyr Lys Glu Gly Leu Gln Gly Ser Leu Thr Ser Leu Lys 
        595                 600                 605             
Asn Pro Leu Thr Met Met Ala Asn His Tyr Lys Gln His Cys Pro Pro 
    610                 615                 620                 
Thr Pro Glu Ser Pro Cys Ala Thr Gln Asn Ile Asn Phe Lys Ser Phe 
625                 630                 635                 640 
Lys Glu Asn Leu Lys Asp Phe Leu Phe Asn Ile Pro Phe Asp Cys Trp 
                645                 650                 655     
Lys Pro Val Lys Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            660                 665                 670         
Gly Gly Gly Ser Ala Pro Ile Thr Ser Ser Ser Thr Lys Glu Thr Glu 
        675                 680                 685             
Gln Gln Met Glu Gln Leu Leu Leu Asp Leu Gln Leu Leu Leu Asn Gly 
    690                 695                 700                 
Val Asn Asn Tyr Glu Asn Pro Gln Leu Ser Arg Met Leu Thr Phe Lys 
705                 710                 715                 720 
Phe Tyr Thr Pro Lys Lys Ala Thr Glu Phe Thr His Leu Gln Cys Leu 
                725                 730                 735     
Ala Glu Glu Leu Lys Asn Leu Glu Glu Val Leu Gly Leu Pro Gln Ser 
            740                 745                 750         
Lys Asn Val His Leu Thr Asp Thr Lys Glu Leu Ile Ser Asn Met Asn 
        755                 760                 765             
Val Thr Leu Leu Lys Leu Lys Gly Ser Glu Thr Ser Tyr Asn Cys Glu 
    770                 775                 780                 
Tyr Asp Asp Glu Thr Ala Thr Ile Thr Glu Phe Leu Asn Lys Trp Ile 
785                 790                 795                 800 
Thr Phe Cys Gln Ser Ile Phe Ser Thr Leu Thr His His His His His 
                805                 810                 815     
His 
    

<210>  3
<211>  816
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  SIGNAL
<222>  (1)..(816)
<223>  融合蛋白


<400>  3
Ile Trp Glu Leu Glu Lys Asn Val Tyr Val Val Glu Leu Asp Trp His 
1               5                   10                  15      
Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asn Thr Pro Glu 
            20                  25                  30          
Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              
Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Ala Asp Ala Gly 
    50                  55                  60                  
Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Phe Leu 
65                  70                  75                  80  
Leu Ile His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Arg 
                85                  90                  95      
Glu Gln Lys Glu Ser Lys Asn Lys Ile Phe Leu Lys Cys Glu Ala Lys 
            100                 105                 110         
Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Ala Ile Ser Thr 
        115                 120                 125             
Asp Leu Lys Phe Thr Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 
Glu Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Lys Val Arg Val 
145                 150                 155                 160 
Asp Asn Arg Asp Tyr Lys Lys Tyr Thr Val Glu Cys Gln Glu Gly Ser 
                165                 170                 175     
Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Val Val Asp 
            180                 185                 190         
Ala Ile His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile 
        195                 200                 205             
Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro 
    210                 215                 220                 
Leu Lys Asn Ser Arg His Val Glu Val Ser Trp Glu Tyr Pro Asp Thr 
225                 230                 235                 240 
Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Gly Val Gln Val 
                245                 250                 255     
Gln Gly Lys Asn Asn Arg Glu Lys Lys Asp Arg Leu Ser Val Asp Lys 
            260                 265                 270         
Thr Ser Ala Lys Val Val Cys His Lys Asp Ala Lys Ile Arg Val Gln 
        275                 280                 285             
Ala Arg Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Asn Trp Ala Ser Val 
    290                 295                 300                 
Ser Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
305                 310                 315                 320 
Gly Ser Arg Asn Leu Pro Thr Pro Thr Pro Ser Pro Gly Met Phe Gln 
                325                 330                 335     
Cys Leu Asn His Ser Gln Thr Leu Leu Arg Ala Ile Ser Asn Thr Leu 
            340                 345                 350         
Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu 
        355                 360                 365             
Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala 
    370                 375                 380                 
Cys Leu Pro Leu Glu Leu Thr Met Asn Glu Ser Cys Leu Ala Ser Arg 
385                 390                 395                 400 
Glu Ile Ser Leu Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr 
                405                 410                 415     
Ser Phe Met Thr Thr Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys 
            420                 425                 430         
Met Tyr Gln Val Glu Phe Lys Ala Met Asn Ala Lys Leu Leu Met Asp 
        435                 440                 445             
Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Thr Ala Ile Asp 
    450                 455                 460                 
Glu Leu Leu Gln Ala Leu Asn Val Asn Ser Val Thr Val Pro Gln Asn 
465                 470                 475                 480 
Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys 
                485                 490                 495     
Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asn Arg Met 
            500                 505                 510         
Met Ser Tyr Leu Asn Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        515                 520                 525             
Ser Gly Gly Gly Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Glu Thr 
    530                 535                 540                 
Gln Gln Gln Leu Glu Gln Leu Leu Leu Asp Leu Arg Leu Leu Leu Asn 
545                 550                 555                 560 
Gly Val Asn Asn Pro Glu Asn Pro Lys Leu Ser Arg Met Leu Thr Phe 
                565                 570                 575     
Lys Phe Tyr Val Pro Lys Lys Ala Thr Glu Leu Thr His Leu Gln Cys 
            580                 585                 590         
Leu Val Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Tyr Leu Ala Gln 
        595                 600                 605             
Ser Lys Asn Phe His Leu Asn His Ile Lys Glu Leu Met Ser Asn Ile 
    610                 615                 620                 
Asn Val Thr Val Leu Lys Leu Lys Gly Ser Glu Thr Arg Phe Thr Cys 
625                 630                 635                 640 
Asn Tyr Asp Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Lys Trp 
                645                 650                 655     
Ile Thr Phe Cys Gln Ser Ile Phe Ser Thr Leu Thr Gly Gly Gly Gly 
            660                 665                 670         
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser 
        675                 680                 685             
Pro Ser Ser Val Thr Arg Pro Trp Gln His Val Asp Ala Met Lys Glu 
    690                 695                 700                 
Ala Leu Ser Leu Leu Asn Asn Ser Ser Glu Ile Thr Ala Val Met Asn 
705                 710                 715                 720 
Glu Thr Val Glu Val Val Ser Glu Met Phe Asp Pro Glu Glu Pro Lys 
                725                 730                 735     
Cys Leu Gln Thr His Leu Lys Leu Tyr Glu Gln Gly Leu Arg Gly Ser 
            740                 745                 750         
Leu Ile Ser Leu Lys Glu Pro Leu Arg Met Met Ala Asn His Tyr Lys 
        755                 760                 765             
Gln His Cys Pro Leu Thr Pro Glu Thr Pro Cys Glu Thr Gln Thr Ile 
    770                 775                 780                 
Thr Phe Lys Asn Phe Lys Glu Lys Leu Lys Asp Phe Leu Phe Asn Asn 
785                 790                 795                 800 
Pro Phe Asp Cys Trp Gly Pro Asp Gln Lys His His His His His His 
                805                 810                 815     

<210>  4
<211>  816
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  SIGNAL
<222>  (1)..(816)
<223>  融合蛋白


<400>  4
Ile Trp Glu Leu Glu Lys Asn Val Tyr Val Val Glu Leu Asp Trp His 
1               5                   10                  15      
Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asn Thr Pro Glu 
            20                  25                  30          
Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              
Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Ala Asp Ala Gly 
    50                  55                  60                  
Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Phe Leu 
65                  70                  75                  80  
Leu Ile His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Arg 
                85                  90                  95      
Glu Gln Lys Glu Ser Lys Asn Lys Ile Phe Leu Lys Cys Glu Ala Lys 
            100                 105                 110         
Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Ala Ile Ser Thr 
        115                 120                 125             
Asp Leu Lys Phe Thr Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 
Glu Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Lys Val Arg Val 
145                 150                 155                 160 
Asp Asn Arg Asp Tyr Lys Lys Tyr Thr Val Glu Cys Gln Glu Gly Ser 
                165                 170                 175     
Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Val Val Asp 
            180                 185                 190         
Ala Ile His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile 
        195                 200                 205             
Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro 
    210                 215                 220                 
Leu Lys Asn Ser Arg His Val Glu Val Ser Trp Glu Tyr Pro Asp Thr 
225                 230                 235                 240 
Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Gly Val Gln Val 
                245                 250                 255     
Gln Gly Lys Asn Asn Arg Glu Lys Lys Asp Arg Leu Ser Val Asp Lys 
            260                 265                 270         
Thr Ser Ala Lys Val Val Cys His Lys Asp Ala Lys Ile Arg Val Gln 
        275                 280                 285             
Ala Arg Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Asn Trp Ala Ser Val 
    290                 295                 300                 
Ser Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
305                 310                 315                 320 
Gly Ser Arg Asn Leu Pro Thr Pro Thr Pro Ser Pro Gly Met Phe Gln 
                325                 330                 335     
Cys Leu Asn His Ser Gln Thr Leu Leu Arg Ala Ile Ser Asn Thr Leu 
            340                 345                 350         
Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu 
        355                 360                 365             
Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala 
    370                 375                 380                 
Cys Leu Pro Leu Glu Leu Thr Met Asn Glu Ser Cys Leu Ala Ser Arg 
385                 390                 395                 400 
Glu Ile Ser Leu Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr 
                405                 410                 415     
Ser Phe Met Thr Thr Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys 
            420                 425                 430         
Met Tyr Gln Val Glu Phe Lys Ala Met Asn Ala Lys Leu Leu Met Asp 
        435                 440                 445             
Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Thr Ala Ile Asp 
    450                 455                 460                 
Glu Leu Leu Gln Ala Leu Asn Val Asn Ser Val Thr Val Pro Gln Asn 
465                 470                 475                 480 
Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys 
                485                 490                 495     
Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asn Arg Met 
            500                 505                 510         
Met Ser Tyr Leu Asn Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        515                 520                 525             
Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Pro Ser Ser Val Thr 
    530                 535                 540                 
Arg Pro Trp Gln His Val Asp Ala Met Lys Glu Ala Leu Ser Leu Leu 
545                 550                 555                 560 
Asn Asn Ser Ser Glu Ile Thr Ala Val Met Asn Glu Thr Val Glu Val 
                565                 570                 575     
Val Ser Glu Met Phe Asp Pro Glu Glu Pro Lys Cys Leu Gln Thr His 
            580                 585                 590         
Leu Lys Leu Tyr Glu Gln Gly Leu Arg Gly Ser Leu Ile Ser Leu Lys 
        595                 600                 605             
Glu Pro Leu Arg Met Met Ala Asn His Tyr Lys Gln His Cys Pro Leu 
    610                 615                 620                 
Thr Pro Glu Thr Pro Cys Glu Thr Gln Thr Ile Thr Phe Lys Asn Phe 
625                 630                 635                 640 
Lys Glu Lys Leu Lys Asp Phe Leu Phe Asn Asn Pro Phe Asp Cys Trp 
                645                 650                 655     
Gly Pro Asp Gln Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            660                 665                 670         
Gly Gly Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Glu Thr Gln Gln 
        675                 680                 685             
Gln Leu Glu Gln Leu Leu Leu Asp Leu Arg Leu Leu Leu Asn Gly Val 
    690                 695                 700                 
Asn Asn Pro Glu Asn Pro Lys Leu Ser Arg Met Leu Thr Phe Lys Phe 
705                 710                 715                 720 
Tyr Val Pro Lys Lys Ala Thr Glu Leu Thr His Leu Gln Cys Leu Val 
                725                 730                 735     
Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Tyr Leu Ala Gln Ser Lys 
            740                 745                 750         
Asn Phe His Leu Asn His Ile Lys Glu Leu Met Ser Asn Ile Asn Val 
        755                 760                 765             
Thr Val Leu Lys Leu Lys Gly Ser Glu Thr Arg Phe Thr Cys Asn Tyr 
    770                 775                 780                 
Asp Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Lys Trp Ile Thr 
785                 790                 795                 800 
Phe Cys Gln Ser Ile Phe Ser Thr Leu Thr His His His His His His 
                805                 810                 815     

<210>  5
<211>  1309
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  SIGNAL
<222>  (1)..(1309)
<223>  融合蛋白


<400>  5
Ile Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Leu Asp Trp His 
1               5                   10                  15      
Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys His Thr Pro Glu 
            20                  25                  30          
Glu Asp Asp Ile Thr Trp Thr Ser Ala Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              
Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  
Gln Tyr Thr Cys His Lys Gly Gly Lys Val Leu Ser Arg Ser Leu Leu 
65                  70                  75                  80  
Leu Ile His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      
Glu Gln Lys Glu Ser Lys Asn Lys Ile Phe Leu Lys Cys Glu Ala Lys 
            100                 105                 110         
Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Ala Ile Ser Thr 
        115                 120                 125             
Asp Leu Lys Phe Ser Val Lys Ser Ser Arg Gly Phe Ser Asp Pro Gln 
    130                 135                 140                 
Gly Val Thr Cys Gly Ala Val Thr Leu Ser Ala Glu Arg Val Arg Val 
145                 150                 155                 160 
Asp Asn Arg Asp Tyr Lys Lys Tyr Thr Val Glu Cys Gln Glu Gly Ser 
                165                 170                 175     
Ala Cys Pro Ser Ala Glu Glu Ser Leu Pro Ile Glu Val Val Val Asp 
            180                 185                 190         
Ala Ile His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile 
        195                 200                 205             
Arg Asp Ile Ile Lys Pro Asp Pro Pro Thr Asn Leu Gln Leu Lys Pro 
    210                 215                 220                 
Leu Lys Asn Ser Arg His Val Glu Val Ser Trp Glu Tyr Pro Asp Thr 
225                 230                 235                 240 
Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Ala 
                245                 250                 255     
Gln Gly Lys Asn Asn Arg Glu Lys Lys Asp Arg Leu Cys Val Asp Lys 
            260                 265                 270         
Thr Ser Ala Lys Val Val Cys His Lys Asp Ala Lys Ile Arg Val Gln 
        275                 280                 285             
Ala Arg Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Asp Trp Ala Ser Val 
    290                 295                 300                 
Ser Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
305                 310                 315                 320 
Gly Ser Arg Ser Leu Pro Thr Ala Ser Pro Ser Pro Gly Ile Phe Gln 
                325                 330                 335     
Cys Leu Asn His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Thr Leu 
            340                 345                 350         
Gln Lys Ala Arg Gln Thr Leu Glu Leu Tyr Ser Cys Thr Ser Glu Glu 
        355                 360                 365             
Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala 
    370                 375                 380                 
Cys Leu Pro Leu Glu Leu Thr Met Asn Glu Ser Cys Leu Ala Ser Arg 
385                 390                 395                 400 
Glu Ile Ser Leu Ile Thr Asn Gly Ser Cys Leu Ala Ser Gly Lys Ala 
                405                 410                 415     
Ser Phe Met Thr Val Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys 
            420                 425                 430         
Met Tyr Gln Met Glu Phe Lys Ala Met Asn Ala Lys Leu Leu Met Asp 
        435                 440                 445             
Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Thr Ala Ile Asp 
    450                 455                 460                 
Glu Leu Leu Gln Ala Leu Asn Phe Asn Ser Val Thr Val Pro Gln Lys 
465                 470                 475                 480 
Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys 
                485                 490                 495     
Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Met 
            500                 505                 510         
Met Ser Tyr Leu Asn Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        515                 520                 525             
Ser Gly Gly Gly Gly Ser Ala Pro Ile Thr Ser Ser Ser Thr Lys Glu 
    530                 535                 540                 
Thr Glu Gln Gln Met Glu Gln Leu Leu Leu Asp Leu Gln Leu Leu Leu 
545                 550                 555                 560 
Asn Gly Val Asn Asn Tyr Glu Asn Pro Gln Leu Ser Arg Met Leu Thr 
                565                 570                 575     
Phe Lys Phe Tyr Thr Pro Lys Lys Ala Thr Glu Phe Thr His Leu Gln 
            580                 585                 590         
Cys Leu Ala Glu Glu Leu Lys Asn Leu Glu Glu Val Leu Gly Leu Pro 
        595                 600                 605             
Gln Ser Lys Asn Val His Leu Thr Asp Thr Lys Glu Leu Ile Ser Asn 
    610                 615                 620                 
Met Asn Val Thr Leu Leu Lys Leu Lys Gly Ser Glu Thr Ser Tyr Asn 
625                 630                 635                 640 
Cys Glu Tyr Asp Asp Glu Thr Ala Thr Ile Thr Glu Phe Leu Asn Lys 
                645                 650                 655     
Trp Ile Thr Phe Cys Gln Ser Ile Phe Ser Thr Leu Thr Gly Gly Gly 
            660                 665                 670         
Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
        675                 680                 685             
Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser 
    690                 695                 700                 
Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp 
705                 710                 715                 720 
Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser 
                725                 730                 735     
Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg 
            740                 745                 750         
Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu 
        755                 760                 765             
Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly 
    770                 775                 780                 
Lys Trp Ser Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
785                 790                 795                 800 
Ser Ser Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly 
                805                 810                 815     
Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
            820                 825                 830         
Ser Gln Ser Val Ser Met Pro Phe Leu Ala Trp Tyr Gln Gln Lys Pro 
        835                 840                 845             
Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 
    850                 855                 860                 
Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
865                 870                 875                 880 
Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
                885                 890                 895     
Gln Gln Met Arg Gly Arg Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 
            900                 905                 910         
Glu Ile Lys Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser 
        915                 920                 925             
Ser Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
    930                 935                 940                 
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
945                 950                 955                 960 
Leu Phe Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                965                 970                 975     
Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp 
            980                 985                 990         
Ser Val Lys Gly Arg Phe Thr Ile  Ser Arg Asp Asn Ser  Lys Asn Thr 
        995                 1000                 1005             
Leu Tyr  Leu Gln Met Asn Ser  Leu Arg Ala Glu Asp  Thr Ala Val Tyr 
    1010                 1015                 1020                 
Tyr  Cys Ala Lys Ser Thr  His Leu Tyr Leu Phe  Asp Tyr Trp Gly Gln  
1025                 1030                 1035                 1040 
Gly Thr Leu Val Thr  Val Ser Ser Gly Gly  Ser Gly Gly Ser Ser  Glu 
                1045                 1050                 1055     
Leu Thr Gln Asp  Pro Ala Val Ser Val  Ala Leu Gly Gln Thr  Val Arg 
            1060                 1065                 1070         
Ile Thr Cys  Gln Gly Asp Ser Leu  Arg Ser Tyr Tyr Ala  Ser Trp Tyr 
        1075                 1080                 1085             
Gln Gln  Lys Pro Gly Gln Ala  Pro Val Leu Val Ile  Tyr Gly Lys Asn 
    1090                 1095                 1100                 
Asn  Arg Pro Ser Gly Ile  Pro Asp Arg Phe Ser  Gly Ser Ser Ser Gly  
1105                 1110                 1115                 1120 
Asn Thr Ala Ser Leu  Thr Ile Thr Gly Ala  Gln Ala Glu Asp Glu  Ala 
                1125                 1130                 1135     
Asp Tyr Tyr Cys  Asn Ser Arg Asp Ser  Ser Gly Asn His Val  Val Phe 
            1140                 1145                 1150         
Gly Gly Gly  Thr Lys Leu Thr Val  Leu Ser Ser Ser Ser  Gly Leu Val 
        1155                 1160                 1165             
Pro Arg  Gly Ser Ser Ser Ser  Gly Ala Pro Thr Arg  Ser Pro Thr Leu 
    1170                 1175                 1180                 
Val  Thr Arg Pro Ser Gln  His Val Asp Ala Ile  Gln Glu Ala Leu Ser  
1185                 1190                 1195                 1200 
Leu Leu Asn Asn Ser  Asn Asp Val Thr Ala  Val Met Asn Lys Ala  Val 
                1205                 1210                 1215     
Lys Val Val Ser  Glu Val Phe Asp Pro  Glu Gly Pro Thr Cys  Leu Glu 
            1220                 1225                 1230         
Thr Arg Leu  Gln Leu Tyr Lys Glu  Gly Leu Gln Gly Ser  Leu Thr Ser 
        1235                 1240                 1245             
Leu Lys  Asn Pro Leu Thr Met  Met Ala Asn His Tyr  Lys Gln His Cys 
    1250                 1255                 1260                 
Pro  Pro Thr Pro Glu Ser  Pro Cys Ala Thr Gln  Asn Ile Asn Phe Lys  
1265                 1270                 1275                 1280 
Ser Phe Lys Glu Asn  Leu Lys Asp Phe Leu  Phe Asn Ile Pro Phe  Asp 
                1285                 1290                 1295     
Cys Trp Lys Pro  Val Lys Lys His His  His His His His 
            1300                 1305                 

<210>  6
<211>  1308
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  SIGNAL
<222>  (1)..(1308)
<223>  融合蛋白


<400>  6
Ile Trp Glu Leu Glu Lys Asn Val Tyr Val Val Glu Leu Asp Trp His 
1               5                   10                  15      
Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asn Thr Pro Glu 
            20                  25                  30          
Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              
Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Ala Asp Ala Gly 
    50                  55                  60                  
Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Phe Leu 
65                  70                  75                  80  
Leu Ile His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Arg 
                85                  90                  95      
Glu Gln Lys Glu Ser Lys Asn Lys Ile Phe Leu Lys Cys Glu Ala Lys 
            100                 105                 110         
Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Ala Ile Ser Thr 
        115                 120                 125             
Asp Leu Lys Phe Thr Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 
Glu Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Lys Val Arg Val 
145                 150                 155                 160 
Asp Asn Arg Asp Tyr Lys Lys Tyr Thr Val Glu Cys Gln Glu Gly Ser 
                165                 170                 175     
Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Val Val Asp 
            180                 185                 190         
Ala Ile His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile 
        195                 200                 205             
Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro 
    210                 215                 220                 
Leu Lys Asn Ser Arg His Val Glu Val Ser Trp Glu Tyr Pro Asp Thr 
225                 230                 235                 240 
Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Gly Val Gln Val 
                245                 250                 255     
Gln Gly Lys Asn Asn Arg Glu Lys Lys Asp Arg Leu Ser Val Asp Lys 
            260                 265                 270         
Thr Ser Ala Lys Val Val Cys His Lys Asp Ala Lys Ile Arg Val Gln 
        275                 280                 285             
Ala Arg Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Asn Trp Ala Ser Val 
    290                 295                 300                 
Ser Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
305                 310                 315                 320 
Gly Ser Arg Asn Leu Pro Thr Pro Thr Pro Ser Pro Gly Met Phe Gln 
                325                 330                 335     
Cys Leu Asn His Ser Gln Thr Leu Leu Arg Ala Ile Ser Asn Thr Leu 
            340                 345                 350         
Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu 
        355                 360                 365             
Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala 
    370                 375                 380                 
Cys Leu Pro Leu Glu Leu Thr Met Asn Glu Ser Cys Leu Ala Ser Arg 
385                 390                 395                 400 
Glu Ile Ser Leu Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr 
                405                 410                 415     
Ser Phe Met Thr Thr Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys 
            420                 425                 430         
Met Tyr Gln Val Glu Phe Lys Ala Met Asn Ala Lys Leu Leu Met Asp 
        435                 440                 445             
Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Thr Ala Ile Asp 
    450                 455                 460                 
Glu Leu Leu Gln Ala Leu Asn Val Asn Ser Val Thr Val Pro Gln Asn 
465                 470                 475                 480 
Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys 
                485                 490                 495     
Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asn Arg Met 
            500                 505                 510         
Met Ser Tyr Leu Asn Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        515                 520                 525             
Ser Gly Gly Gly Gly Ser Ala Pro Ala Ser Ser Ser Thr Lys Glu Thr 
    530                 535                 540                 
Gln Gln Gln Leu Glu Gln Leu Leu Leu Asp Leu Arg Leu Leu Leu Asn 
545                 550                 555                 560 
Gly Val Asn Asn Pro Glu Asn Pro Lys Leu Ser Arg Met Leu Thr Phe 
                565                 570                 575     
Lys Phe Tyr Val Pro Lys Lys Ala Thr Glu Leu Thr His Leu Gln Cys 
            580                 585                 590         
Leu Val Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Tyr Leu Ala Gln 
        595                 600                 605             
Ser Lys Asn Phe His Leu Asn His Ile Lys Glu Leu Met Ser Asn Ile 
    610                 615                 620                 
Asn Val Thr Val Leu Lys Leu Lys Gly Ser Glu Thr Arg Phe Thr Cys 
625                 630                 635                 640 
Asn Tyr Asp Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Lys Trp 
                645                 650                 655     
Ile Thr Phe Cys Gln Ser Ile Phe Ser Thr Leu Thr Gly Gly Gly Gly 
            660                 665                 670         
Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
        675                 680                 685             
Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Leu 
    690                 695                 700                 
Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp Gly 
705                 710                 715                 720 
Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile 
                725                 730                 735     
Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val 
            740                 745                 750         
Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser 
        755                 760                 765             
Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Lys 
    770                 775                 780                 
Trp Ser Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
785                 790                 795                 800 
Ser Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr 
                805                 810                 815     
Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
            820                 825                 830         
Gln Ser Val Ser Met Pro Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
        835                 840                 845             
Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly 
    850                 855                 860                 
Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
865                 870                 875                 880 
Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 
                885                 890                 895     
Gln Met Arg Gly Arg Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu 
            900                 905                 910         
Ile Lys Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser 
        915                 920                 925             
Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    930                 935                 940                 
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu 
945                 950                 955                 960 
Phe Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                965                 970                 975     
Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser 
            980                 985                 990         
Val Lys Gly Arg Phe Thr Ile Ser  Arg Asp Asn Ser Lys  Asn Thr Leu 
        995                 1000                 1005             
Tyr Leu  Gln Met Asn Ser Leu  Arg Ala Glu Asp Thr  Ala Val Tyr Tyr 
    1010                 1015                 1020                 
Cys  Ala Lys Ser Thr His  Leu Tyr Leu Phe Asp  Tyr Trp Gly Gln Gly  
1025                 1030                 1035                 1040 
Thr Leu Val Thr Val  Ser Ser Gly Gly Ser  Gly Gly Ser Ser Glu  Leu 
                1045                 1050                 1055     
Thr Gln Asp Pro  Ala Val Ser Val Ala  Leu Gly Gln Thr Val  Arg Ile 
            1060                 1065                 1070         
Thr Cys Gln  Gly Asp Ser Leu Arg  Ser Tyr Tyr Ala Ser  Trp Tyr Gln 
        1075                 1080                 1085             
Gln Lys  Pro Gly Gln Ala Pro  Val Leu Val Ile Tyr  Gly Lys Asn Asn 
    1090                 1095                 1100                 
Arg  Pro Ser Gly Ile Pro  Asp Arg Phe Ser Gly  Ser Ser Ser Gly Asn  
1105                 1110                 1115                 1120 
Thr Ala Ser Leu Thr  Ile Thr Gly Ala Gln  Ala Glu Asp Glu Ala  Asp 
                1125                 1130                 1135     
Tyr Tyr Cys Asn  Ser Arg Asp Ser Ser  Gly Asn His Val Val  Phe Gly 
            1140                 1145                 1150         
Gly Gly Thr  Lys Leu Thr Val Leu  Ser Ser Ser Ser Gly  Leu Val Pro 
        1155                 1160                 1165             
Arg Gly  Ser Ser Ser Ser Gly  Ala Pro Thr Ser Ser  Pro Ser Ser Val 
    1170                 1175                 1180                 
Thr  Arg Pro Trp Gln His  Val Asp Ala Met Lys  Glu Ala Leu Ser Leu  
1185                 1190                 1195                 1200 
Leu Asn Asn Ser Ser  Glu Ile Thr Ala Val  Met Asn Glu Thr Val  Glu 
                1205                 1210                 1215     
Val Val Ser Glu  Met Phe Asp Pro Glu  Glu Pro Lys Cys Leu  Gln Thr 
            1220                 1225                 1230         
His Leu Lys  Leu Tyr Glu Gln Gly  Leu Arg Gly Ser Leu  Ile Ser Leu 
        1235                 1240                 1245             
Lys Glu  Pro Leu Arg Met Met  Ala Asn His Tyr Lys  Gln His Cys Pro 
    1250                 1255                 1260                 
Leu  Thr Pro Glu Thr Pro  Cys Glu Thr Gln Thr  Ile Thr Phe Lys Asn  
1265                 1270                 1275                 1280 
Phe Lys Glu Lys Leu  Lys Asp Phe Leu Phe  Asn Asn Pro Phe Asp  Cys 
                1285                 1290                 1295     
Trp Gly Pro Asp  Gln Lys His His His  His His His 
            1300                 1305             

