                         SEQUENCE LISTING

<110> 祁展楷
 
<120> 眼镜蛇神经毒素多肽对鸦片类药品痛觉过敏和耐受的抑制及对其镇痛的协同增效作用

<130>  SNY-001

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  62
<212>  PRT
<213>  Naja atra or Naja kaouthia （中华眼镜蛇或孟加拉眼镜蛇）

<400>  1

Leu Glu Cys His Asn Gln Gln Ser Ser Gln Thr Pro Thr Thr Thr Gly 
1               5                   10                  15      


Cys Ser Gly Gly Glu Thr Asn Cys Tyr Lys Lys Arg Trp Arg Asp His 
            20                  25                  30          


Arg Gly Tyr Arg Thr Glu Arg Gly Cys Gly Cys Pro Ser Val Lys Asn 
        35                  40                  45              


Gly Ile Glu Ile Asn Cys Cys Thr Thr Asp Arg Cys Asn Asn 
    50                  55                  60          


<210>  2
<211>  83
<212>  PRT
<213>  Naja atra or Naja kaouthia （中华眼镜蛇或孟加拉眼镜蛇）

<400>  2

Met Lys Thr Leu Leu Leu Thr Leu Leu Val Val Thr Ile Val Cys Leu 
1               5                   10                  15      


Asp Leu Gly Tyr Thr Leu Glu Cys His Asn Gln Gln Ser Ser Gln Thr 
            20                  25                  30          


Pro Thr Thr Thr Gly Cys Ser Gly Gly Glu Thr Asn Cys Tyr Lys Lys 
        35                  40                  45              


Arg Trp Arg Asp His Arg Gly Tyr Arg Thr Glu Arg Gly Cys Gly Cys 
    50                  55                  60                  


Pro Ser Val Lys Asn Gly Ile Glu Ile Asn Cys Cys Thr Thr Asp Arg 
65                  70                  75                  80  


Cys Asn Asn 
            


<210>  3
<211>  74
<212>  PRT
<213>  Bungarus multicinctus （银环蛇）

<400>  3

Ile Val Cys His Thr Thr Ala Thr Ser Pro Ile Ser Ala Val Thr Cys 
1               5                   10                  15      


Pro Pro Gly Glu Asn Leu Cys Tyr Arg Lys Met Trp Cys Asp Ala Phe 
            20                  25                  30          


Cys Ser Ser Arg Gly Lys Val Val Glu Leu Gly Cys Ala Ala Thr Cys 
        35                  40                  45              


Pro Ser Lys Lys Pro Tyr Glu Glu Val Thr Cys Cys Ser Thr Asp Lys 
    50                  55                  60                  


Cys Asn Pro His Pro Lys Gln Arg Pro Gly 
65                  70                  


<210>  4
<211>  74
<212>  PRT
<213>  Bungarus multicinctus （银环蛇）

<400>  4

Ile Val Cys His Thr Thr Ala Thr Ser Pro Ile Ser Ala Val Thr Cys 
1               5                   10                  15      


Pro Pro Gly Glu Asn Leu Cys Tyr Arg Lys Met Trp Cys Asp Ala Phe 
            20                  25                  30          


Cys Ser Ser Arg Gly Lys Val Val Glu Leu Gly Cys Ala Ala Thr Cys 
        35                  40                  45              


Pro Ser Lys Lys Pro Tyr Glu Glu Val Thr Cys Cys Ser Thr Asp Lys 
    50                  55                  60                  


Cys Asn Pro His Pro Lys Gln Arg Pro Gly 
65                  70                  


<210>  5
<211>  68
<212>  PRT
<213>  Bungarus multicinctus （银环蛇）

<400>  5

Met Gln Cys Lys Thr Cys Ser Phe Tyr Thr Cys Pro Asn Ser Glu Thr 
1               5                   10                  15      


Cys Pro Asp Gly Lys Asn Ile Cys Val Lys Arg Ser Trp Thr Ala Val 
            20                  25                  30          


Ala Gly Asp Gly Leu Lys Arg Glu Ile Arg Arg Glu Cys Ala Ala Thr 
        35                  40                  45              


Cys Pro Pro Ser Lys Leu Gly Leu Thr Val Phe Cys Cys Thr Thr Asp 
    50                  55                  60                  


Asn Cys Asn His 
65              


<210>  6
<211>  68
<212>  PRT
<213>  Bungarus multicinctus （银环蛇）

<400>  6

Met Gln Cys Lys Thr Cys Ser Phe Tyr Thr Cys Pro Asn Ser Glu Thr 
1               5                   10                  15      


Cys Pro Asp Gly Lys Asn Ile Cys Val Lys Arg Ser Trp Thr Ala Val 
            20                  25                  30          


Ala Gly Asp Gly Leu Lys Arg Glu Ile Arg Arg Glu Cys Ala Ala Thr 
        35                  40                  45              


Cys Pro Pro Ser Lys Leu Gly Leu Thr Val Phe Cys Cys Thr Thr Asp 
    50                  55                  60                  


Asn Cys Asn His 
65              


<210>  7
<211>  72
<212>  PRT
<213>  Ophiophagus hannah  （ 眼镜王蛇）

<400>  7

Ile Arg Cys Phe Ile Thr Pro Asp Val Thr Ser Gln Ala Cys Pro Asp 
1               5                   10                  15      


Gly Gln Asn Ile Cys Tyr Thr Lys Thr Trp Cys Asp Asn Phe Cys Gly 
            20                  25                  30          


Met Arg Gly Lys Arg Val Asp Leu Gly Cys Ala Ala Thr Cys Pro Thr 
        35                  40                  45              


Val Lys Pro Gly Val Asp Ile Lys Cys Cys Ser Thr Asp Asn Cys Asn 
    50                  55                  60                  


Pro Phe Pro Thr Arg Glu Arg Ser 
65                  70          


<210>  8
<211>  71
<212>  PRT
<213>  Ophiophagus hannah （ 眼镜王蛇）

<400>  8

Ile Arg Cys Phe Ile Thr Pro Asp Val Thr Ser Gln Ala Cys Pro Asp 
1               5                   10                  15      


Gly His Val Cys Tyr Thr Lys Met Trp Cys Asp Asn Phe Cys Gly Met 
            20                  25                  30          


Arg Gly Lys Arg Val Asp Leu Gly Cys Ala Ala Thr Cys Pro Lys Val 
        35                  40                  45              


Lys Pro Gly Val Asn Ile Lys Cys Cys Ser Arg Asp Asn Cys Asn Pro 
    50                  55                  60                  


Phe Pro Thr Arg Lys Arg Ser 
65                  70      


<210>  9
<211>  72
<212>  PRT
<213>  Ophiophagus hannah （ 眼镜王蛇）

<400>  9

Thr Lys Cys Tyr Lys Thr Gly Asp Arg Ile Ile Ser Glu Ala Cys Pro 
1               5                   10                  15      


Pro Gly Gln Asp Leu Cys Tyr Met Lys Thr Trp Cys Asp Val Phe Cys 
            20                  25                  30          


Gly Thr Arg Gly Arg Val Ile Glu Leu Gly Cys Thr Ala Thr Cys Pro 
        35                  40                  45              


Thr Val Lys Pro His Glu Gln Ile Thr Cys Cys Ser Thr Asp Asn Cys 
    50                  55                  60                  


Asp Pro His His Lys Met Leu Gln 
65                  70          


<210>  10
<211>  61
<212>  PRT
<213>  Naja kaouthia （孟加拉眼镜蛇）

<400>  10

Leu Glu Cys His Asn Gln Gln Ser Ser Gln Ala Pro Thr Thr Lys Thr 
1               5                   10                  15      


Cys Ser Gly Glu Thr Asn Cys Tyr Lys Lys Trp Trp Ser Asp His Arg 
            20                  25                  30          


Gly Thr Ile Ile Glu Arg Gly Cys Gly Cys Pro Lys Val Lys Pro Gly 
        35                  40                  45              


Val Asn Leu Asn Cys Cys Arg Thr Asp Arg Cys Asn Asn 
    50                  55                  60      


<210>  11
<211>  62
<212>  PRT
<213>  Naja kaouthia （孟加拉眼镜蛇）

<400>  11

Leu Glu Cys His Asn Gln Gln Ser Ile Gln Thr Pro Thr Thr Thr Gly 
1               5                   10                  15      


Cys Ser Gly Gly Glu Thr Asn Cys Tyr Lys Lys Arg Trp Arg Asp His 
            20                  25                  30          


Arg Gly Tyr Arg Thr Glu Arg Gly Cys Gly Cys Pro Ser Val Lys Asn 
        35                  40                  45              


Gly Ile Glu Ile Asn Cys Cys Thr Thr Asp Arg Cys Asn Asn 
    50                  55                  60          


<210>  12
<211>  83
<212>  PRT
<213>  Naja kaouthia （孟加拉眼镜蛇）

<400>  12

Met Lys Thr Leu Leu Leu Thr Leu Leu Val Val Thr Ile Val Cys Leu 
1               5                   10                  15      


Asp Leu Gly Tyr Thr Leu Glu Cys His Asn Gln Gln Ser Ser Gln Thr 
            20                  25                  30          


Pro Thr Thr Thr Gly Cys Ser Gly Gly Glu Thr Asn Cys Tyr Lys Lys 
        35                  40                  45              


Arg Trp Arg Asp His Arg Gly Tyr Arg Thr Glu Arg Gly Cys Gly Cys 
    50                  55                  60                  


Pro Ser Val Lys Asn Gly Ile Glu Ile Asn Cys Cys Thr Thr Asp Arg 
65                  70                  75                  80  


Cys Asn Asn 
            


