                         SEQUENCE LISTING

<110>  Monash University
 
<120>  Methods for making recombinant protein

<130>  53084188AZD

<150>  AU2019902468
<151>  2019-07-12

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  2433
<212>  DNA
<213>  Homo sapiens

<400>  1
atggaacaca aagaagtggt gttgctcctg ctgctgttcc tgaagtccgg ccagggcgag       60

cccctggacg attacgtgaa cacccagggc gccagcctgt tcagcgtgac caagaaacag      120

ctgggagccg gcagcatcga ggaatgcgcc gccaagtgcg aagaggacga ggaattcacc      180

tgtcgggcct tccagtacca cagcaaagaa cagcagtgcg tgatcatggc cgagaacaga      240

aagagcagca tcatcatcag aatgcgggac gtggtgctgt tcgagaagaa ggtgtacctg      300

agcgagtgca agaccggcaa cggcaagaac taccggggca ccatgagcaa gaccaagaac      360

ggcatcacct gtcagaagtg gtccagcacc agcccccacc ggcctagatt ttctccagcc      420

acccacccta gcgagggcct ggaagagaac tactgccgga accccgacaa cgaccctcag      480

ggcccttggt gctacaccac cgaccccgag aagagatacg actactgcga catcctggaa      540

tgtgaagagg aatgcatgca ctgcagcggc gagaactacg acggcaagat ctccaagacc      600

atgagcggcc tggaatgcca ggcttgggac agccagtctc ctcacgccca cggctacatc      660

cccagcaagt tccccaacaa gaacctgaag aagaattact gcagaaaccc tgaccgcgag      720

ctgcggccct ggtgttttac caccgatcct aacaagagat gggagctgtg cgatatcccc      780

cggtgcacca cacctccacc tagcagcggc cctacctacc agtgtctgaa gggcaccggc      840

gagaattaca ggggcaacgt ggccgtgacc gtgtccggcc atacctgcca gcattggagc      900

gcccagaccc cccacaccca caacagaacc cccgagaact tcccctgcaa gaatctggac      960

gagaattatt gtcgcaaccc cgatggcaag agggccccct ggtgtcacac caccaacagc     1020

caggtgcgct gggagtactg caagatcccc agctgcgata gcagccccgt gtccacagaa     1080

cagctggccc ctacagcccc tcctgagctg acacctgtgg tgcaggattg ctaccacggc     1140

gacggccaga gctacagagg caccagcagc accaccacaa ccggcaagaa gtgccagagc     1200

tggtcctcca tgacccctca ccggcaccag aaaacccctg agaattaccc caacgccggc     1260

ctgaccatga actactgtag aaatcccgac gccgacaagg gaccctggtg cttcacaaca     1320

gacccttccg tcagatggga atactgtaat ctgaagaagt gcagcggcac cgaggccagc     1380

gtggtggctc ctccaccagt ggtgctgctg cccgatgtgg aaaccccctc cgaagaggac     1440

tgtatgttcg gcaatggcaa gggctataga ggcaagcggg ccaccaccgt gaccggcaca     1500

ccttgtcagg attgggccgc tcaggaaccc cacagacaca gcatcttcac cccagagaca     1560

aaccctcggg ccggactgga aaaaaactat tgtcggaatc ctgacggcga cgtgggagga     1620

ccttggtgtt atacaacaaa cccacggaag ctgtacgatt actgtgacgt gccccagtgt     1680

gccgccccta gcttcgattg tggcaagccc caggtggaac ccaagaaatg ccccggcaga     1740

gtcgtgggcg gatgtgtggc ccatcctcac tcttggcctt ggcaggtgtc cctgcggacc     1800

agattcggca tgcacttttg cggcggcacc ctgatcagcc ccgagtgggt gctgacagcc     1860

gcccactgtc tggaaaagtc ccccagaccc agcagctaca aagtgatcct gggagcccac     1920

caggaagtga acctggaacc tcacgtgcag gaaatcgagg tgtccagact gttcctggaa     1980

cccacccgga aggatatcgc cctgctgaag ctgagcagcc ctgccgtgat caccgacaaa     2040

gtgattcccg cctgcctgcc cagccccaac tatgtggtgg ccgacagaac cgagtgcttc     2100

atcaccggct ggggcgagac acagggcaca tttggagccg gcctgctgaa agaggcccag     2160

ctgcctgtga tcgagaacaa agtgtgcaac cgctacgagt tcctgaacgg cagagtgcag     2220

agcaccgagc tgtgtgccgg acatctggct ggcggcacag atagctgtca gggcgattct     2280

ggcggccctc tcgtgtgctt cgagaaggac aagtacatcc tgcagggcgt gaccagctgg     2340

ggcctgggat gtgccagacc taacaagccc ggcgtgtacg tgcgcgtgtc cagatttgtg     2400

acctggatcg agggcgtgat gcggaacaac tga                                  2433


<210>  2
<211>  810
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Thr Gln Gly Ala Ser 
            20                  25                  30          


Leu Phe Ser Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Ile Glu Glu 
        35                  40                  45              


Cys Ala Ala Lys Cys Glu Glu Asp Glu Glu Phe Thr Cys Arg Ala Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys 
                85                  90                  95      


Lys Val Tyr Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg 
            100                 105                 110         


Gly Thr Met Ser Lys Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp Ser 
        115                 120                 125             


Ser Thr Ser Pro His Arg Pro Arg Phe Ser Pro Ala Thr His Pro Ser 
    130                 135                 140                 


Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Pro Gln 
145                 150                 155                 160 


Gly Pro Trp Cys Tyr Thr Thr Asp Pro Glu Lys Arg Tyr Asp Tyr Cys 
                165                 170                 175     


Asp Ile Leu Glu Cys Glu Glu Glu Cys Met His Cys Ser Gly Glu Asn 
            180                 185                 190         


Tyr Asp Gly Lys Ile Ser Lys Thr Met Ser Gly Leu Glu Cys Gln Ala 
        195                 200                 205             


Trp Asp Ser Gln Ser Pro His Ala His Gly Tyr Ile Pro Ser Lys Phe 
    210                 215                 220                 


Pro Asn Lys Asn Leu Lys Lys Asn Tyr Cys Arg Asn Pro Asp Arg Glu 
225                 230                 235                 240 


Leu Arg Pro Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Leu 
                245                 250                 255     


Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Ser Ser Gly Pro Thr 
            260                 265                 270         


Tyr Gln Cys Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly Asn Val Ala 
        275                 280                 285             


Val Thr Val Ser Gly His Thr Cys Gln His Trp Ser Ala Gln Thr Pro 
    290                 295                 300                 


His Thr His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Asp 
305                 310                 315                 320 


Glu Asn Tyr Cys Arg Asn Pro Asp Gly Lys Arg Ala Pro Trp Cys His 
                325                 330                 335     


Thr Thr Asn Ser Gln Val Arg Trp Glu Tyr Cys Lys Ile Pro Ser Cys 
            340                 345                 350         


Asp Ser Ser Pro Val Ser Thr Glu Gln Leu Ala Pro Thr Ala Pro Pro 
        355                 360                 365             


Glu Leu Thr Pro Val Val Gln Asp Cys Tyr His Gly Asp Gly Gln Ser 
    370                 375                 380                 


Tyr Arg Gly Thr Ser Ser Thr Thr Thr Thr Gly Lys Lys Cys Gln Ser 
385                 390                 395                 400 


Trp Ser Ser Met Thr Pro His Arg His Gln Lys Thr Pro Glu Asn Tyr 
                405                 410                 415     


Pro Asn Ala Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp 
            420                 425                 430         


Lys Gly Pro Trp Cys Phe Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr 
        435                 440                 445             


Cys Asn Leu Lys Lys Cys Ser Gly Thr Glu Ala Ser Val Val Ala Pro 
    450                 455                 460                 


Pro Pro Val Val Leu Leu Pro Asp Val Glu Thr Pro Ser Glu Glu Asp 
465                 470                 475                 480 


Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys Arg Ala Thr Thr 
                485                 490                 495     


Val Thr Gly Thr Pro Cys Gln Asp Trp Ala Ala Gln Glu Pro His Arg 
            500                 505                 510         


His Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys 
        515                 520                 525             


Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Cys Tyr 
    530                 535                 540                 


Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro Gln Cys 
545                 550                 555                 560 


Ala Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys 
                565                 570                 575     


Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro His Ser Trp 
            580                 585                 590         


Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met His Phe Cys Gly 
        595                 600                 605             


Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu 
    610                 615                 620                 


Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His 
625                 630                 635                 640 


Gln Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg 
                645                 650                 655     


Leu Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys Leu Ser 
            660                 665                 670         


Ser Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser 
        675                 680                 685             


Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp 
    690                 695                 700                 


Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln 
705                 710                 715                 720 


Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn 
                725                 730                 735     


Gly Arg Val Gln Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly 
            740                 745                 750         


Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu 
        755                 760                 765             


Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys 
    770                 775                 780                 


Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val 
785                 790                 795                 800 


Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
                805                 810 


<210>  3
<211>  1209
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  recombinant PAI-1 Q197C and G355C

<400>  3
atgcagatgt ctcccgccct gacctgcctg gtgctgggcc tggccctggt gttcggagag       60

ggctctgccg tgcaccaccc acctagctac gtggcacacc tggcctccga cttcggcgtg      120

agggtgtttc agcaggtggc ccaggccagc aaggatcgca acgtggtgtt cagcccttat      180

ggcgtggcct ccgtgctggc catgctccag ctgaccacag gaggagagac ccagcagcag      240

atccaggcag ctatgggctt caagatcgac gataagggaa tggcacccgc cctgaggcac      300

ctgtacaagg agctgatggg cccttggaat aaggacgaga tcagcaccac agatgccatc      360

tttgtgcagc gcgacctgaa gctggtgcag ggcttcatgc cacacttctt tcggctgttc      420

cggagcaccg tgaagcaggt ggacttcagc gaggtggaga gggcccgctt tatcatcaac      480

gattgggtga agacccacac aaagggcatg atcagcaatc tgctgggcaa gggagcagtg      540

gatcagctga ccaggctggt gctggtgaac gccctgtact tcaatggctg ctggaagacc      600

ccatttcccg acagctccac acaccggaga ctgttccaca agtccgatgg ctctacagtg      660

agcgtgccta tgatggccca gaccaacaag ttcaattata cagagtttac cacacctgac      720

ggccactact atgacatcct ggagctgcca taccacggcg acaccctgag catgtttatc      780

gccgcccctt atgagaagga ggtgccactg tccgccctga caaacatcct gtccgcccag      840

ctgatctctc actggaaggg caatatgacc aggctgccaa ggctgctggt gctgcctaag      900

ttctccctgg agacagaggt ggacctgcgg aagcctctgg agaacctggg catgaccgat      960

atgttcagac agtttcaggc cgactttaca tctctgagcg atcaggagcc actgcacgtg     1020

gcacaggccc tccagaaggt gaagatcgag gtgaacgagt cctgtaccgt ggcctctagc     1080

tccacagccg tgatcgtgtc tgccaggatg gccccagagg agatcatcat ggatcggccc     1140

ttcctgtttg tggtgagaca caatccaacc ggcacagtgc tgttcatggg ccaggtcatg     1200

gagccctga                                                             1209


<210>  4
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant PAI-1, Q197C, G355C

<400>  4

Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu 
1               5                   10                  15      


Val Phe Gly Glu Gly Ser Ala Val His His Pro Pro Ser Tyr Val Ala 
            20                  25                  30          


His Leu Ala Ser Asp Phe Gly Val Arg Val Phe Gln Gln Val Ala Gln 
        35                  40                  45              


Ala Ser Lys Asp Arg Asn Val Val Phe Ser Pro Tyr Gly Val Ala Ser 
    50                  55                  60                  


Val Leu Ala Met Leu Gln Leu Thr Thr Gly Gly Glu Thr Gln Gln Gln 
65                  70                  75                  80  


Ile Gln Ala Ala Met Gly Phe Lys Ile Asp Asp Lys Gly Met Ala Pro 
                85                  90                  95      


Ala Leu Arg His Leu Tyr Lys Glu Leu Met Gly Pro Trp Asn Lys Asp 
            100                 105                 110         


Glu Ile Ser Thr Thr Asp Ala Ile Phe Val Gln Arg Asp Leu Lys Leu 
        115                 120                 125             


Val Gln Gly Phe Met Pro His Phe Phe Arg Leu Phe Arg Ser Thr Val 
    130                 135                 140                 


Lys Gln Val Asp Phe Ser Glu Val Glu Arg Ala Arg Phe Ile Ile Asn 
145                 150                 155                 160 


Asp Trp Val Lys Thr His Thr Lys Gly Met Ile Ser Asn Leu Leu Gly 
                165                 170                 175     


Lys Gly Ala Val Asp Gln Leu Thr Arg Leu Val Leu Val Asn Ala Leu 
            180                 185                 190         


Tyr Phe Asn Gly Cys Trp Lys Thr Pro Phe Pro Asp Ser Ser Thr His 
        195                 200                 205             


Arg Arg Leu Phe His Lys Ser Asp Gly Ser Thr Val Ser Val Pro Met 
    210                 215                 220                 


Met Ala Gln Thr Asn Lys Phe Asn Tyr Thr Glu Phe Thr Thr Pro Asp 
225                 230                 235                 240 


Gly His Tyr Tyr Asp Ile Leu Glu Leu Pro Tyr His Gly Asp Thr Leu 
                245                 250                 255     


Ser Met Phe Ile Ala Ala Pro Tyr Glu Lys Glu Val Pro Leu Ser Ala 
            260                 265                 270         


Leu Thr Asn Ile Leu Ser Ala Gln Leu Ile Ser His Trp Lys Gly Asn 
        275                 280                 285             


Met Thr Arg Leu Pro Arg Leu Leu Val Leu Pro Lys Phe Ser Leu Glu 
    290                 295                 300                 


Thr Glu Val Asp Leu Arg Lys Pro Leu Glu Asn Leu Gly Met Thr Asp 
305                 310                 315                 320 


Met Phe Arg Gln Phe Gln Ala Asp Phe Thr Ser Leu Ser Asp Gln Glu 
                325                 330                 335     


Pro Leu His Val Ala Gln Ala Leu Gln Lys Val Lys Ile Glu Val Asn 
            340                 345                 350         


Glu Ser Cys Thr Val Ala Ser Ser Ser Thr Ala Val Ile Val Ser Ala 
        355                 360                 365             


Arg Met Ala Pro Glu Glu Ile Ile Met Asp Arg Pro Phe Leu Phe Val 
    370                 375                 380                 


Val Arg His Asn Pro Thr Gly Thr Val Leu Phe Met Gly Gln Val Met 
385                 390                 395                 400 


Glu Pro 
        


<210>  5
<211>  4241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hPlg-IRES2-PAI-1 expression cassette

<400>  5
atggaacaca aagaagtggt gttgctcctg ctgctgttcc tgaagtccgg ccagggcgag       60

cccctggacg attacgtgaa cacccagggc gccagcctgt tcagcgtgac caagaaacag      120

ctgggagccg gcagcatcga ggaatgcgcc gccaagtgcg aagaggacga ggaattcacc      180

tgtcgggcct tccagtacca cagcaaagaa cagcagtgcg tgatcatggc cgagaacaga      240

aagagcagca tcatcatcag aatgcgggac gtggtgctgt tcgagaagaa ggtgtacctg      300

agcgagtgca agaccggcaa cggcaagaac taccggggca ccatgagcaa gaccaagaac      360

ggcatcacct gtcagaagtg gtccagcacc agcccccacc ggcctagatt ttctccagcc      420

acccacccta gcgagggcct ggaagagaac tactgccgga accccgacaa cgaccctcag      480

ggcccttggt gctacaccac cgaccccgag aagagatacg actactgcga catcctggaa      540

tgtgaagagg aatgcatgca ctgcagcggc gagaactacg acggcaagat ctccaagacc      600

atgagcggcc tggaatgcca ggcttgggac agccagtctc ctcacgccca cggctacatc      660

cccagcaagt tccccaacaa gaacctgaag aagaattact gcagaaaccc tgaccgcgag      720

ctgcggccct ggtgttttac caccgatcct aacaagagat gggagctgtg cgatatcccc      780

cggtgcacca cacctccacc tagcagcggc cctacctacc agtgtctgaa gggcaccggc      840

gagaattaca ggggcaacgt ggccgtgacc gtgtccggcc atacctgcca gcattggagc      900

gcccagaccc cccacaccca caacagaacc cccgagaact tcccctgcaa gaatctggac      960

gagaattatt gtcgcaaccc cgatggcaag agggccccct ggtgtcacac caccaacagc     1020

caggtgcgct gggagtactg caagatcccc agctgcgata gcagccccgt gtccacagaa     1080

cagctggccc ctacagcccc tcctgagctg acacctgtgg tgcaggattg ctaccacggc     1140

gacggccaga gctacagagg caccagcagc accaccacaa ccggcaagaa gtgccagagc     1200

tggtcctcca tgacccctca ccggcaccag aaaacccctg agaattaccc caacgccggc     1260

ctgaccatga actactgtag aaatcccgac gccgacaagg gaccctggtg cttcacaaca     1320

gacccttccg tcagatggga atactgtaat ctgaagaagt gcagcggcac cgaggccagc     1380

gtggtggctc ctccaccagt ggtgctgctg cccgatgtgg aaaccccctc cgaagaggac     1440

tgtatgttcg gcaatggcaa gggctataga ggcaagcggg ccaccaccgt gaccggcaca     1500

ccttgtcagg attgggccgc tcaggaaccc cacagacaca gcatcttcac cccagagaca     1560

aaccctcggg ccggactgga aaaaaactat tgtcggaatc ctgacggcga cgtgggagga     1620

ccttggtgtt atacaacaaa cccacggaag ctgtacgatt actgtgacgt gccccagtgt     1680

gccgccccta gcttcgattg tggcaagccc caggtggaac ccaagaaatg ccccggcaga     1740

gtcgtgggcg gatgtgtggc ccatcctcac tcttggcctt ggcaggtgtc cctgcggacc     1800

agattcggca tgcacttttg cggcggcacc ctgatcagcc ccgagtgggt gctgacagcc     1860

gcccactgtc tggaaaagtc ccccagaccc agcagctaca aagtgatcct gggagcccac     1920

caggaagtga acctggaacc tcacgtgcag gaaatcgagg tgtccagact gttcctggaa     1980

cccacccgga aggatatcgc cctgctgaag ctgagcagcc ctgccgtgat caccgacaaa     2040

gtgattcccg cctgcctgcc cagccccaac tatgtggtgg ccgacagaac cgagtgcttc     2100

atcaccggct ggggcgagac acagggcaca tttggagccg gcctgctgaa agaggcccag     2160

ctgcctgtga tcgagaacaa agtgtgcaac cgctacgagt tcctgaacgg cagagtgcag     2220

agcaccgagc tgtgtgccgg acatctggct ggcggcacag atagctgtca gggcgattct     2280

ggcggccctc tcgtgtgctt cgagaaggac aagtacatcc tgcagggcgt gaccagctgg     2340

ggcctgggat gtgccagacc taacaagccc ggcgtgtacg tgcgcgtgtc cagatttgtg     2400

acctggatcg agggcgtgat gcggaacaac tgaaagcttg gtaccgagct cggatccccc     2460

ctctccctcc ccccccccta acgttactgg ccgaagccgc ttggaataag gccggtgtgc     2520

gtttgtctat atgttatttt ccaccatatt gccgtctttt ggcaatgtga gggcccggaa     2580

acctggccct gtcttcttga cgagcattcc taggggtctt tcccctctcg ccaaaggaat     2640

gcaaggtctg ttgaatgtcg tgaaggaagc agttcctctg gaagcttctt gaagacaaac     2700

aacgtctgta gcgacccttt gcaggcagcg gaacccccca cctggcgaca ggtgcctctg     2760

cggccaaaag ccacgtgtat aagatacacc tgcaaaggcg gcacaacccc agtgccacgt     2820

tgtgagttgg atagttgtgg aaagagtcaa atggctctcc tcaagcgtat tcaacaaggg     2880

gctgaaggat gcccagaagg taccccattg tatgggatct gatctggggc ctcggtacac     2940

atgctttaca tgtgtttagt cgaggttaaa aaaacgtcta ggccccccga accacgggga     3000

cgtggttttc ctttgaaaaa cacgatgata atatgcagat gtctcccgcc ctgacctgcc     3060

tggtgctggg cctggccctg gtgttcggag agggctctgc cgtgcaccac ccacctagct     3120

acgtggcaca cctggcctcc gacttcggcg tgagggtgtt tcagcaggtg gcccaggcca     3180

gcaaggatcg caacgtggtg ttcagccctt atggcgtggc ctccgtgctg gccatgctcc     3240

agctgaccac aggaggagag acccagcagc agatccaggc agctatgggc ttcaagatcg     3300

acgataaggg aatggcaccc gccctgaggc acctgtacaa ggagctgatg ggcccttgga     3360

ataaggacga gatcagcacc acagatgcca tctttgtgca gcgcgacctg aagctggtgc     3420

agggcttcat gccacacttc tttcggctgt tccggagcac cgtgaagcag gtggacttca     3480

gcgaggtgga gagggcccgc tttatcatca acgattgggt gaagacccac acaaagggca     3540

tgatcagcaa tctgctgggc aagggagcag tggatcagct gaccaggctg gtgctggtga     3600

acgccctgta cttcaatggc tgctggaaga ccccatttcc cgacagctcc acacaccgga     3660

gactgttcca caagtccgat ggctctacag tgagcgtgcc tatgatggcc cagaccaaca     3720

agttcaatta tacagagttt accacacctg acggccacta ctatgacatc ctggagctgc     3780

cataccacgg cgacaccctg agcatgttta tcgccgcccc ttatgagaag gaggtgccac     3840

tgtccgccct gacaaacatc ctgtccgccc agctgatctc tcactggaag ggcaatatga     3900

ccaggctgcc aaggctgctg gtgctgccta agttctccct ggagacagag gtggacctgc     3960

ggaagcctct ggagaacctg ggcatgaccg atatgttcag acagtttcag gccgacttta     4020

catctctgag cgatcaggag ccactgcacg tggcacaggc cctccagaag gtgaagatcg     4080

aggtgaacga gtcctgtacc gtggcctcta gctccacagc cgtgatcgtg tctgccagga     4140

tggccccaga ggagatcatc atggatcggc ccttcctgtt tgtggtgaga cacaatccaa     4200

ccggcacagt gctgttcatg ggccaggtca tggagccctg a                         4241


<210>  6
<211>  2433
<212>  DNA
<213>  Homo sapiens

<400>  6
atggaacaca aagaagtggt gttgctcctg ctgctgttcc tgaagtccgg ccagggcgag       60

cccctggacg attacgtgaa cacccagggc gccagcctgt tcagcgtgac caagaaacag      120

ctgggagccg gcagcatcga ggaatgcgcc gccaagtgcg aagaggacga ggaattcacc      180

tgtcgggcct tccagtacca cagcaaagaa cagcagtgcg tgatcatggc cgagaacaga      240

aagagcagca tcatcatcag aatgcgggac gtggtgctgt tcgagaagaa ggtgtacctg      300

agcgagtgca agaccggcaa cggcaagaac taccggggca ccatgagcaa gaccaagaac      360

ggcatcacct gtcagaagtg gtccagcacc agcccccacc ggcctagatt ttctccagcc      420

acccacccta gcgagggcct ggaagagaac tactgccgga accccgacaa cgaccctcag      480

ggcccttggt gctacaccac cgaccccgag aagagatacg actactgcga catcctggaa      540

tgtgaagagg aatgcatgca ctgcagcggc gagaactacg acggcaagat ctccaagacc      600

atgagcggcc tggaatgcca ggcttgggac agccagtctc ctcacgccca cggctacatc      660

cccagcaagt tccccaacaa gaacctgaag aagaattact gcagaaaccc tgaccgcgag      720

ctgcggccct ggtgttttac caccgatcct aacaagagat gggagctgtg cgatatcccc      780

cggtgcacca cacctccacc tagcagcggc cctacctacc agtgtctgaa gggcaccggc      840

gagaattaca ggggcaacgt ggccgtgacc gtgtccggcc atacctgcca gcattggagc      900

gcccagaccc cccacaccca caacagaacc cccgagaact tcccctgcaa gaatctggac      960

gagaattatt gtcgcaaccc cgatggcaag agggccccct ggtgtcacac caccaacagc     1020

caggtgcgct gggagtactg caagatcccc agctgcgata gcagccccgt gtccacagaa     1080

cagctggccc ctacagcccc tcctgagctg acacctgtgg tgcaggattg ctaccacggc     1140

gacggccaga gctacagagg caccagcagc accaccacaa ccggcaagaa gtgccagagc     1200

tggtcctcca tgacccctca ccggcaccag aaaacccctg agaattaccc caacgccggc     1260

ctgaccatga actactgtag aaatcccgac gccgacaagg gaccctggtg cttcacaaca     1320

gacccttccg tcagatggga atactgtaat ctgaagaagt gcagcggcac cgaggccagc     1380

gtggtggctc ctccaccagt ggtgctgctg cccgatgtgg aaaccccctc cgaagaggac     1440

tgtatgttcg gcaatggcaa gggctataga ggcaagcggg ccaccaccgt gaccggcaca     1500

ccttgtcagg attgggccgc tcaggaaccc cacagacaca gcatcttcac cccagagaca     1560

aaccctcggg ccggactgga aaaaaactat tgtcggaatc ctgacggcga cgtgggagga     1620

ccttggtgtt atacaacaaa cccacggaag ctgtacgatt actgtgacgt gccccagtgt     1680

gccgccccta gcttcgattg tggcaagccc caggtggaac ccaagaaatg ccccggcaga     1740

gtcgtgggcg gatgtgtggc ccatcctcac tcttggcctt ggcaggtgtc cctgcggacc     1800

agattcggca tgcacttttg cggcggcacc ctgatcagcc ccgagtgggt gctgacagcc     1860

gcccactgtc tggaaaagtc ccccagaccc agcagctaca aagtgatcct gggagcccac     1920

caggaagtga acctggaacc tcacgtgcag gaaatcgagg tgtccagact gttcctggaa     1980

cccacccgga aggatatcgc cctgctgaag ctgagcagcc ctgccgtgat caccgacaaa     2040

gtgattcccg cctgcctgcc cagccccaac tatgtggtgg ccgacagaac cgagtgcttc     2100

atcaccggct ggggcgagac acagggcaca tttggagccg gcctgctgaa agaggcccag     2160

ctgcctgtga tcgagaacaa agtgtgcaac cgctacgagt tcctgaacgg cagagtgcag     2220

agcaccgagc tgtgtgccgg acatctggct ggcggcacag atagctgtca gggcgattct     2280

ggcggccctc tcgtgtgctt cgagaaggac aagtacatcc tgcagggcgt gaccagctgg     2340

ggcctgggat gtgccagacc taacaagccc ggcgtgtacg tgcgcgtgtc cagatttgtg     2400

acctggatcg agggcgtgat gcggaacaac tga                                  2433


<210>  7
<211>  810
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Thr Gln Gly Ala Ser 
            20                  25                  30          


Leu Phe Ser Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Ile Glu Glu 
        35                  40                  45              


Cys Ala Ala Lys Cys Glu Glu Asp Glu Glu Phe Thr Cys Arg Ala Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys 
                85                  90                  95      


Lys Val Tyr Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg 
            100                 105                 110         


Gly Thr Met Ser Lys Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp Ser 
        115                 120                 125             


Ser Thr Ser Pro His Arg Pro Arg Phe Ser Pro Ala Thr His Pro Ser 
    130                 135                 140                 


Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Pro Gln 
145                 150                 155                 160 


Gly Pro Trp Cys Tyr Thr Thr Asp Pro Glu Lys Arg Tyr Asp Tyr Cys 
                165                 170                 175     


Asp Ile Leu Glu Cys Glu Glu Glu Cys Met His Cys Ser Gly Glu Asn 
            180                 185                 190         


Tyr Asp Gly Lys Ile Ser Lys Thr Met Ser Gly Leu Glu Cys Gln Ala 
        195                 200                 205             


Trp Asp Ser Gln Ser Pro His Ala His Gly Tyr Ile Pro Ser Lys Phe 
    210                 215                 220                 


Pro Asn Lys Asn Leu Lys Lys Asn Tyr Cys Arg Asn Pro Asp Arg Glu 
225                 230                 235                 240 


Leu Arg Pro Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Leu 
                245                 250                 255     


Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Ser Ser Gly Pro Thr 
            260                 265                 270         


Tyr Gln Cys Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly Asn Val Ala 
        275                 280                 285             


Val Thr Val Ser Gly His Thr Cys Gln His Trp Ser Ala Gln Thr Pro 
    290                 295                 300                 


His Thr His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Asp 
305                 310                 315                 320 


Glu Asn Tyr Cys Arg Asn Pro Asp Gly Lys Arg Ala Pro Trp Cys His 
                325                 330                 335     


Thr Thr Asn Ser Gln Val Arg Trp Glu Tyr Cys Lys Ile Pro Ser Cys 
            340                 345                 350         


Asp Ser Ser Pro Val Ser Thr Glu Gln Leu Ala Pro Thr Ala Pro Pro 
        355                 360                 365             


Glu Leu Thr Pro Val Val Gln Asp Cys Tyr His Gly Asp Gly Gln Ser 
    370                 375                 380                 


Tyr Arg Gly Thr Ser Ser Thr Thr Thr Thr Gly Lys Lys Cys Gln Ser 
385                 390                 395                 400 


Trp Ser Ser Met Thr Pro His Arg His Gln Lys Thr Pro Glu Asn Tyr 
                405                 410                 415     


Pro Asn Ala Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp 
            420                 425                 430         


Lys Gly Pro Trp Cys Phe Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr 
        435                 440                 445             


Cys Asn Leu Lys Lys Cys Ser Gly Thr Glu Ala Ser Val Val Ala Pro 
    450                 455                 460                 


Pro Pro Val Val Leu Leu Pro Asp Val Glu Thr Pro Ser Glu Glu Asp 
465                 470                 475                 480 


Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys Arg Ala Thr Thr 
                485                 490                 495     


Val Thr Gly Thr Pro Cys Gln Asp Trp Ala Ala Gln Glu Pro His Arg 
            500                 505                 510         


His Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys 
        515                 520                 525             


Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Cys Tyr 
    530                 535                 540                 


Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro Gln Cys 
545                 550                 555                 560 


Ala Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys 
                565                 570                 575     


Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro His Ser Trp 
            580                 585                 590         


Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met His Phe Cys Gly 
        595                 600                 605             


Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu 
    610                 615                 620                 


Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His 
625                 630                 635                 640 


Gln Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg 
                645                 650                 655     


Leu Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys Leu Ser 
            660                 665                 670         


Ser Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser 
        675                 680                 685             


Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp 
    690                 695                 700                 


Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln 
705                 710                 715                 720 


Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn 
                725                 730                 735     


Gly Arg Val Gln Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly 
            740                 745                 750         


Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu 
        755                 760                 765             


Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys 
    770                 775                 780                 


Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val 
785                 790                 795                 800 


Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
                805                 810 


<210>  8
<211>  2202
<212>  DNA
<213>  Homo sapiens

<400>  8
atggaacaca aagaagtggt gttgctcctg ctgctgttcc tgaagtccgg ccagggcaag       60

gtgtacctga gcgagtgcaa gaccggcaac ggcaagaact accggggcac catgagcaag      120

accaagaacg gcatcacctg tcagaagtgg tccagcacca gcccccaccg gcctagattt      180

tctccagcca cccaccctag cgagggcctg gaagagaact actgccggaa ccccgacaac      240

gaccctcagg gcccttggtg ctacaccacc gaccccgaga agagatacga ctactgcgac      300

atcctggaat gtgaagagga atgcatgcac tgcagcggcg agaactacga cggcaagatc      360

tccaagacca tgagcggcct ggaatgccag gcttgggaca gccagtctcc tcacgcccac      420

ggctacatcc ccagcaagtt ccccaacaag aacctgaaga agaattactg cagaaaccct      480

gaccgcgagc tgcggccctg gtgttttacc accgatccta acaagagatg ggagctgtgc      540

gatatccccc ggtgcaccac acctccacct agcagcggcc ctacctacca gtgtctgaag      600

ggcaccggcg agaattacag gggcaacgtg gccgtgaccg tgtccggcca tacctgccag      660

cattggagcg cccagacccc ccacacccac aacagaaccc ccgagaactt cccctgcaag      720

aatctggacg agaattattg tcgcaacccc gatggcaaga gggccccctg gtgtcacacc      780

accaacagcc aggtgcgctg ggagtactgc aagatcccca gctgcgatag cagccccgtg      840

tccacagaac agctggcccc tacagcccct cctgagctga cacctgtggt gcaggattgc      900

taccacggcg acggccagag ctacagaggc accagcagca ccaccacaac cggcaagaag      960

tgccagagct ggtcctccat gacccctcac cggcaccaga aaacccctga gaattacccc     1020

aacgccggcc tgaccatgaa ctactgtaga aatcccgacg ccgacaaggg accctggtgc     1080

ttcacaacag acccttccgt cagatgggaa tactgtaatc tgaagaagtg cagcggcacc     1140

gaggccagcg tggtggctcc tccaccagtg gtgctgctgc ccgatgtgga aaccccctcc     1200

gaagaggact gtatgttcgg caatggcaag ggctatagag gcaagcgggc caccaccgtg     1260

accggcacac cttgtcagga ttgggccgct caggaacccc acagacacag catcttcacc     1320

ccagagacaa accctcgggc cggactggaa aaaaactatt gtcggaatcc tgacggcgac     1380

gtgggaggac cttggtgtta tacaacaaac ccacggaagc tgtacgatta ctgtgacgtg     1440

ccccagtgtg ccgcccctag cttcgattgt ggcaagcccc aggtggaacc caagaaatgc     1500

cccggcagag tcgtgggcgg atgtgtggcc catcctcact cttggccttg gcaggtgtcc     1560

ctgcggacca gattcggcat gcacttttgc ggcggcaccc tgatcagccc cgagtgggtg     1620

ctgacagccg cccactgtct ggaaaagtcc cccagaccca gcagctacaa agtgatcctg     1680

ggagcccacc aggaagtgaa cctggaacct cacgtgcagg aaatcgaggt gtccagactg     1740

ttcctggaac ccacccggaa ggatatcgcc ctgctgaagc tgagcagccc tgccgtgatc     1800

accgacaaag tgattcccgc ctgcctgccc agccccaact atgtggtggc cgacagaacc     1860

gagtgcttca tcaccggctg gggcgagaca cagggcacat ttggagccgg cctgctgaaa     1920

gaggcccagc tgcctgtgat cgagaacaaa gtgtgcaacc gctacgagtt cctgaacggc     1980

agagtgcaga gcaccgagct gtgtgccgga catctggctg gcggcacaga tagctgtcag     2040

ggcgattctg gcggccctct cgtgtgcttc gagaaggaca agtacatcct gcagggcgtg     2100

accagctggg gcctgggatg tgccagacct aacaagcccg gcgtgtacgt gcgcgtgtcc     2160

agatttgtga cctggatcga gggcgtgatg cggaacaact ga                        2202


<210>  9
<211>  733
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Lys Val Tyr Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys 
            20                  25                  30          


Asn Tyr Arg Gly Thr Met Ser Lys Thr Lys Asn Gly Ile Thr Cys Gln 
        35                  40                  45              


Lys Trp Ser Ser Thr Ser Pro His Arg Pro Arg Phe Ser Pro Ala Thr 
    50                  55                  60                  


His Pro Ser Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn 
65                  70                  75                  80  


Asp Pro Gln Gly Pro Trp Cys Tyr Thr Thr Asp Pro Glu Lys Arg Tyr 
                85                  90                  95      


Asp Tyr Cys Asp Ile Leu Glu Cys Glu Glu Glu Cys Met His Cys Ser 
            100                 105                 110         


Gly Glu Asn Tyr Asp Gly Lys Ile Ser Lys Thr Met Ser Gly Leu Glu 
        115                 120                 125             


Cys Gln Ala Trp Asp Ser Gln Ser Pro His Ala His Gly Tyr Ile Pro 
    130                 135                 140                 


Ser Lys Phe Pro Asn Lys Asn Leu Lys Lys Asn Tyr Cys Arg Asn Pro 
145                 150                 155                 160 


Asp Arg Glu Leu Arg Pro Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg 
                165                 170                 175     


Trp Glu Leu Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Ser Ser 
            180                 185                 190         


Gly Pro Thr Tyr Gln Cys Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly 
        195                 200                 205             


Asn Val Ala Val Thr Val Ser Gly His Thr Cys Gln His Trp Ser Ala 
    210                 215                 220                 


Gln Thr Pro His Thr His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys 
225                 230                 235                 240 


Asn Leu Asp Glu Asn Tyr Cys Arg Asn Pro Asp Gly Lys Arg Ala Pro 
                245                 250                 255     


Trp Cys His Thr Thr Asn Ser Gln Val Arg Trp Glu Tyr Cys Lys Ile 
            260                 265                 270         


Pro Ser Cys Asp Ser Ser Pro Val Ser Thr Glu Gln Leu Ala Pro Thr 
        275                 280                 285             


Ala Pro Pro Glu Leu Thr Pro Val Val Gln Asp Cys Tyr His Gly Asp 
    290                 295                 300                 


Gly Gln Ser Tyr Arg Gly Thr Ser Ser Thr Thr Thr Thr Gly Lys Lys 
305                 310                 315                 320 


Cys Gln Ser Trp Ser Ser Met Thr Pro His Arg His Gln Lys Thr Pro 
                325                 330                 335     


Glu Asn Tyr Pro Asn Ala Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro 
            340                 345                 350         


Asp Ala Asp Lys Gly Pro Trp Cys Phe Thr Thr Asp Pro Ser Val Arg 
        355                 360                 365             


Trp Glu Tyr Cys Asn Leu Lys Lys Cys Ser Gly Thr Glu Ala Ser Val 
    370                 375                 380                 


Val Ala Pro Pro Pro Val Val Leu Leu Pro Asp Val Glu Thr Pro Ser 
385                 390                 395                 400 


Glu Glu Asp Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys Arg 
                405                 410                 415     


Ala Thr Thr Val Thr Gly Thr Pro Cys Gln Asp Trp Ala Ala Gln Glu 
            420                 425                 430         


Pro His Arg His Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly 
        435                 440                 445             


Leu Glu Lys Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly Gly Pro 
    450                 455                 460                 


Trp Cys Tyr Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val 
465                 470                 475                 480 


Pro Gln Cys Ala Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu 
                485                 490                 495     


Pro Lys Lys Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro 
            500                 505                 510         


His Ser Trp Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met His 
        515                 520                 525             


Phe Cys Gly Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala 
    530                 535                 540                 


His Cys Leu Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu 
545                 550                 555                 560 


Gly Ala His Gln Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu 
                565                 570                 575     


Val Ser Arg Leu Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu 
            580                 585                 590         


Lys Leu Ser Ser Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys 
        595                 600                 605             


Leu Pro Ser Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile 
    610                 615                 620                 


Thr Gly Trp Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys 
625                 630                 635                 640 


Glu Ala Gln Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu 
                645                 650                 655     


Phe Leu Asn Gly Arg Val Gln Ser Thr Glu Leu Cys Ala Gly His Leu 
            660                 665                 670         


Ala Gly Gly Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val 
        675                 680                 685             


Cys Phe Glu Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly 
    690                 695                 700                 


Leu Gly Cys Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser 
705                 710                 715                 720 


Arg Phe Val Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
                725                 730             


<210>  10
<211>  1365
<212>  DNA
<213>  Homo sapiens

<400>  10
atggaacaca aagaagtggt gttgctcctg ctgctgttcc tgaagtccgg ccagggcgat       60

tgctaccacg gcgacggcca gagctacaga ggcaccagca gcaccaccac aaccggcaag      120

aagtgccaga gctggtcctc catgacccct caccggcacc agaaaacccc tgagaattac      180

cccaacgccg gcctgaccat gaactactgt agaaatcccg acgccgacaa gggaccctgg      240

tgcttcacaa cagacccttc cgtcagatgg gaatactgta atctgaagaa gtgcagcggc      300

accgaggcca gcgtggtggc tcctccacca gtggtgctgc tgcccgatgt ggaaaccccc      360

tccgaagagg actgtatgtt cggcaatggc aagggctata gaggcaagcg ggccaccacc      420

gtgaccggca caccttgtca ggattgggcc gctcaggaac cccacagaca cagcatcttc      480

accccagaga caaaccctcg ggccggactg gaaaaaaact attgtcggaa tcctgacggc      540

gacgtgggag gaccttggtg ttatacaaca aacccacgga agctgtacga ttactgtgac      600

gtgccccagt gtgccgcccc tagcttcgat tgtggcaagc cccaggtgga acccaagaaa      660

tgccccggca gagtcgtggg cggatgtgtg gcccatcctc actcttggcc ttggcaggtg      720

tccctgcgga ccagattcgg catgcacttt tgcggcggca ccctgatcag ccccgagtgg      780

gtgctgacag ccgcccactg tctggaaaag tcccccagac ccagcagcta caaagtgatc      840

ctgggagccc accaggaagt gaacctggaa cctcacgtgc aggaaatcga ggtgtccaga      900

ctgttcctgg aacccacccg gaaggatatc gccctgctga agctgagcag ccctgccgtg      960

atcaccgaca aagtgattcc cgcctgcctg cccagcccca actatgtggt ggccgacaga     1020

accgagtgct tcatcaccgg ctggggcgag acacagggca catttggagc cggcctgctg     1080

aaagaggccc agctgcctgt gatcgagaac aaagtgtgca accgctacga gttcctgaac     1140

ggcagagtgc agagcaccga gctgtgtgcc ggacatctgg ctggcggcac agatagctgt     1200

cagggcgatt ctggcggccc tctcgtgtgc ttcgagaagg acaagtacat cctgcagggc     1260

gtgaccagct ggggcctggg atgtgccaga cctaacaagc ccggcgtgta cgtgcgcgtg     1320

tccagatttg tgacctggat cgagggcgtg atgcggaaca actga                     1365


<210>  11
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Asp Cys Tyr His Gly Asp Gly Gln Ser Tyr Arg Gly Thr 
            20                  25                  30          


Ser Ser Thr Thr Thr Thr Gly Lys Lys Cys Gln Ser Trp Ser Ser Met 
        35                  40                  45              


Thr Pro His Arg His Gln Lys Thr Pro Glu Asn Tyr Pro Asn Ala Gly 
    50                  55                  60                  


Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp Lys Gly Pro Trp 
65                  70                  75                  80  


Cys Phe Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr Cys Asn Leu Lys 
                85                  90                  95      


Lys Cys Ser Gly Thr Glu Ala Ser Val Val Ala Pro Pro Pro Val Val 
            100                 105                 110         


Leu Leu Pro Asp Val Glu Thr Pro Ser Glu Glu Asp Cys Met Phe Gly 
        115                 120                 125             


Asn Gly Lys Gly Tyr Arg Gly Lys Arg Ala Thr Thr Val Thr Gly Thr 
    130                 135                 140                 


Pro Cys Gln Asp Trp Ala Ala Gln Glu Pro His Arg His Ser Ile Phe 
145                 150                 155                 160 


Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys Asn Tyr Cys Arg 
                165                 170                 175     


Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Cys Tyr Thr Thr Asn Pro 
            180                 185                 190         


Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro Gln Cys Ala Ala Pro Ser 
        195                 200                 205             


Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys Cys Pro Gly Arg 
    210                 215                 220                 


Val Val Gly Gly Cys Val Ala His Pro His Ser Trp Pro Trp Gln Val 
225                 230                 235                 240 


Ser Leu Arg Thr Arg Phe Gly Met His Phe Cys Gly Gly Thr Leu Ile 
                245                 250                 255     


Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu Glu Lys Ser Pro 
            260                 265                 270         


Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His Gln Glu Val Asn 
        275                 280                 285             


Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg Leu Phe Leu Glu 
    290                 295                 300                 


Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys Leu Ser Ser Pro Ala Val 
305                 310                 315                 320 


Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser Pro Asn Tyr Val 
                325                 330                 335     


Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp Gly Glu Thr Gln 
            340                 345                 350         


Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln Leu Pro Val Ile 
        355                 360                 365             


Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn Gly Arg Val Gln 
    370                 375                 380                 


Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly Thr Asp Ser Cys 
385                 390                 395                 400 


Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu Lys Asp Lys Tyr 
                405                 410                 415     


Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys Ala Arg Pro Asn 
            420                 425                 430         


Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val Thr Trp Ile Glu 
        435                 440                 445             


Gly Val Met Arg Asn Asn 
    450                 


<210>  12
<211>  1056
<212>  DNA
<213>  Homo sapiens

<400>  12
atggaacaca aagaagtggt gttgctcctg ctgctgttcc tgaagtccgg ccagggcgag       60

gactgtatgt tcggcaatgg caagggctat agaggcaagc gggccaccac cgtgaccggc      120

acaccttgtc aggattgggc cgctcaggaa ccccacagac acagcatctt caccccagag      180

acaaaccctc gggccggact ggaaaaaaac tattgtcgga atcctgacgg cgacgtggga      240

ggaccttggt gttatacaac aaacccacgg aagctgtacg attactgtga cgtgccccag      300

tgtgccgccc ctagcttcga ttgtggcaag ccccaggtgg aacccaagaa atgccccggc      360

agagtcgtgg gcggatgtgt ggcccatcct cactcttggc cttggcaggt gtccctgcgg      420

accagattcg gcatgcactt ttgcggcggc accctgatca gccccgagtg ggtgctgaca      480

gccgcccact gtctggaaaa gtcccccaga cccagcagct acaaagtgat cctgggagcc      540

caccaggaag tgaacctgga acctcacgtg caggaaatcg aggtgtccag actgttcctg      600

gaacccaccc ggaaggatat cgccctgctg aagctgagca gccctgccgt gatcaccgac      660

aaagtgattc ccgcctgcct gcccagcccc aactatgtgg tggccgacag aaccgagtgc      720

ttcatcaccg gctggggcga gacacagggc acatttggag ccggcctgct gaaagaggcc      780

cagctgcctg tgatcgagaa caaagtgtgc aaccgctacg agttcctgaa cggcagagtg      840

cagagcaccg agctgtgtgc cggacatctg gctggcggca cagatagctg tcagggcgat      900

tctggcggcc ctctcgtgtg cttcgagaag gacaagtaca tcctgcaggg cgtgaccagc      960

tggggcctgg gatgtgccag acctaacaag cccggcgtgt acgtgcgcgt gtccagattt     1020

gtgacctgga tcgagggcgt gatgcggaac aactga                               1056


<210>  13
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Glu Asp Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly 
            20                  25                  30          


Lys Arg Ala Thr Thr Val Thr Gly Thr Pro Cys Gln Asp Trp Ala Ala 
        35                  40                  45              


Gln Glu Pro His Arg His Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg 
    50                  55                  60                  


Ala Gly Leu Glu Lys Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly 
65                  70                  75                  80  


Gly Pro Trp Cys Tyr Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys 
                85                  90                  95      


Asp Val Pro Gln Cys Ala Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln 
            100                 105                 110         


Val Glu Pro Lys Lys Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala 
        115                 120                 125             


His Pro His Ser Trp Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly 
    130                 135                 140                 


Met His Phe Cys Gly Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr 
145                 150                 155                 160 


Ala Ala His Cys Leu Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val 
                165                 170                 175     


Ile Leu Gly Ala His Gln Glu Val Asn Leu Glu Pro His Val Gln Glu 
            180                 185                 190         


Ile Glu Val Ser Arg Leu Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala 
        195                 200                 205             


Leu Leu Lys Leu Ser Ser Pro Ala Val Ile Thr Asp Lys Val Ile Pro 
    210                 215                 220                 


Ala Cys Leu Pro Ser Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys 
225                 230                 235                 240 


Phe Ile Thr Gly Trp Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu 
                245                 250                 255     


Leu Lys Glu Ala Gln Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg 
            260                 265                 270         


Tyr Glu Phe Leu Asn Gly Arg Val Gln Ser Thr Glu Leu Cys Ala Gly 
        275                 280                 285             


His Leu Ala Gly Gly Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
    290                 295                 300                 


Leu Val Cys Phe Glu Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser 
305                 310                 315                 320 


Trp Gly Leu Gly Cys Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg 
                325                 330                 335     


Val Ser Arg Phe Val Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
            340                 345                 350     


<210>  14
<211>  807
<212>  DNA
<213>  Homo sapiens

<400>  14
atggaacaca aagaagtggt gttgctcctg ctgctgttcc tgaagtccgg ccagggcgcc       60

cctagcttcg attgtggcaa gccccaggtg gaacccaaga aatgccccgg cagagtcgtg      120

ggcggatgtg tggcccatcc tcactcttgg ccttggcagg tgtccctgcg gaccagattc      180

ggcatgcact tttgcggcgg caccctgatc agccccgagt gggtgctgac agccgcccac      240

tgtctggaaa agtcccccag acccagcagc tacaaagtga tcctgggagc ccaccaggaa      300

gtgaacctgg aacctcacgt gcaggaaatc gaggtgtcca gactgttcct ggaacccacc      360

cggaaggata tcgccctgct gaagctgagc agccctgccg tgatcaccga caaagtgatt      420

cccgcctgcc tgcccagccc caactatgtg gtggccgaca gaaccgagtg cttcatcacc      480

ggctggggcg agacacaggg cacatttgga gccggcctgc tgaaagaggc ccagctgcct      540

gtgatcgaga acaaagtgtg caaccgctac gagttcctga acggcagagt gcagagcacc      600

gagctgtgtg ccggacatct ggctggcggc acagatagct gtcagggcga ttctggcggc      660

cctctcgtgt gcttcgagaa ggacaagtac atcctgcagg gcgtgaccag ctggggcctg      720

ggatgtgcca gacctaacaa gcccggcgtg tacgtgcgcg tgtccagatt tgtgacctgg      780

atcgagggcg tgatgcggaa caactga                                          807


<210>  15
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro 
            20                  25                  30          


Lys Lys Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro His 
        35                  40                  45              


Ser Trp Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met His Phe 
    50                  55                  60                  


Cys Gly Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His 
65                  70                  75                  80  


Cys Leu Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly 
                85                  90                  95      


Ala His Gln Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu Val 
            100                 105                 110         


Ser Arg Leu Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys 
        115                 120                 125             


Leu Ser Ser Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu 
    130                 135                 140                 


Pro Ser Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr 
145                 150                 155                 160 


Gly Trp Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu 
                165                 170                 175     


Ala Gln Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe 
            180                 185                 190         


Leu Asn Gly Arg Val Gln Ser Thr Glu Leu Cys Ala Gly His Leu Ala 
        195                 200                 205             


Gly Gly Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys 
    210                 215                 220                 


Phe Glu Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu 
225                 230                 235                 240 


Gly Cys Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg 
                245                 250                 255     


Phe Val Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
            260                 265             


<210>  16
<211>  791
<212>  PRT
<213>  Homo sapiens

<400>  16

Glu Pro Leu Asp Asp Tyr Val Asn Thr Gln Gly Ala Ser Leu Phe Ser 
1               5                   10                  15      


Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Ile Glu Glu Cys Ala Ala 
            20                  25                  30          


Lys Cys Glu Glu Asp Glu Glu Phe Thr Cys Arg Ala Phe Gln Tyr His 
        35                  40                  45              


Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Arg Lys Ser Ser 
    50                  55                  60                  


Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys Lys Val Tyr 
65                  70                  75                  80  


Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg Gly Thr Met 
                85                  90                  95      


Ser Lys Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp Ser Ser Thr Ser 
            100                 105                 110         


Pro His Arg Pro Arg Phe Ser Pro Ala Thr His Pro Ser Glu Gly Leu 
        115                 120                 125             


Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Pro Gln Gly Pro Trp 
    130                 135                 140                 


Cys Tyr Thr Thr Asp Pro Glu Lys Arg Tyr Asp Tyr Cys Asp Ile Leu 
145                 150                 155                 160 


Glu Cys Glu Glu Glu Cys Met His Cys Ser Gly Glu Asn Tyr Asp Gly 
                165                 170                 175     


Lys Ile Ser Lys Thr Met Ser Gly Leu Glu Cys Gln Ala Trp Asp Ser 
            180                 185                 190         


Gln Ser Pro His Ala His Gly Tyr Ile Pro Ser Lys Phe Pro Asn Lys 
        195                 200                 205             


Asn Leu Lys Lys Asn Tyr Cys Arg Asn Pro Asp Arg Glu Leu Arg Pro 
    210                 215                 220                 


Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Leu Cys Asp Ile 
225                 230                 235                 240 


Pro Arg Cys Thr Thr Pro Pro Pro Ser Ser Gly Pro Thr Tyr Gln Cys 
                245                 250                 255     


Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly Asn Val Ala Val Thr Val 
            260                 265                 270         


Ser Gly His Thr Cys Gln His Trp Ser Ala Gln Thr Pro His Thr His 
        275                 280                 285             


Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Asp Glu Asn Tyr 
    290                 295                 300                 


Cys Arg Asn Pro Asp Gly Lys Arg Ala Pro Trp Cys His Thr Thr Asn 
305                 310                 315                 320 


Ser Gln Val Arg Trp Glu Tyr Cys Lys Ile Pro Ser Cys Asp Ser Ser 
                325                 330                 335     


Pro Val Ser Thr Glu Gln Leu Ala Pro Thr Ala Pro Pro Glu Leu Thr 
            340                 345                 350         


Pro Val Val Gln Asp Cys Tyr His Gly Asp Gly Gln Ser Tyr Arg Gly 
        355                 360                 365             


Thr Ser Ser Thr Thr Thr Thr Gly Lys Lys Cys Gln Ser Trp Ser Ser 
    370                 375                 380                 


Met Thr Pro His Arg His Gln Lys Thr Pro Glu Asn Tyr Pro Asn Ala 
385                 390                 395                 400 


Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp Lys Gly Pro 
                405                 410                 415     


Trp Cys Phe Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr Cys Asn Leu 
            420                 425                 430         


Lys Lys Cys Ser Gly Thr Glu Ala Ser Val Val Ala Pro Pro Pro Val 
        435                 440                 445             


Val Leu Leu Pro Asp Val Glu Thr Pro Ser Glu Glu Asp Cys Met Phe 
    450                 455                 460                 


Gly Asn Gly Lys Gly Tyr Arg Gly Lys Arg Ala Thr Thr Val Thr Gly 
465                 470                 475                 480 


Thr Pro Cys Gln Asp Trp Ala Ala Gln Glu Pro His Arg His Ser Ile 
                485                 490                 495     


Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys Asn Tyr Cys 
            500                 505                 510         


Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Cys Tyr Thr Thr Asn 
        515                 520                 525             


Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro Gln Cys Ala Ala Pro 
    530                 535                 540                 


Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys Cys Pro Gly 
545                 550                 555                 560 


Arg Val Val Gly Gly Cys Val Ala His Pro His Ser Trp Pro Trp Gln 
                565                 570                 575     


Val Ser Leu Arg Thr Arg Phe Gly Met His Phe Cys Gly Gly Thr Leu 
            580                 585                 590         


Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu Glu Lys Ser 
        595                 600                 605             


Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His Gln Glu Val 
    610                 615                 620                 


Asn Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg Leu Phe Leu 
625                 630                 635                 640 


Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys Leu Ser Ser Pro Ala 
                645                 650                 655     


Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser Pro Asn Tyr 
            660                 665                 670         


Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp Gly Glu Thr 
        675                 680                 685             


Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln Leu Pro Val 
    690                 695                 700                 


Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn Gly Arg Val 
705                 710                 715                 720 


Gln Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly Thr Asp Ser 
                725                 730                 735     


Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu Lys Asp Lys 
            740                 745                 750         


Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys Ala Arg Pro 
        755                 760                 765             


Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val Thr Trp Ile 
    770                 775                 780                 


Glu Gly Val Met Arg Asn Asn 
785                 790     


<210>  17
<211>  714
<212>  PRT
<213>  Homo sapiens

<400>  17

Lys Val Tyr Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg 
1               5                   10                  15      


Gly Thr Met Ser Lys Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp Ser 
            20                  25                  30          


Ser Thr Ser Pro His Arg Pro Arg Phe Ser Pro Ala Thr His Pro Ser 
        35                  40                  45              


Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Pro Gln 
    50                  55                  60                  


Gly Pro Trp Cys Tyr Thr Thr Asp Pro Glu Lys Arg Tyr Asp Tyr Cys 
65                  70                  75                  80  


Asp Ile Leu Glu Cys Glu Glu Glu Cys Met His Cys Ser Gly Glu Asn 
                85                  90                  95      


Tyr Asp Gly Lys Ile Ser Lys Thr Met Ser Gly Leu Glu Cys Gln Ala 
            100                 105                 110         


Trp Asp Ser Gln Ser Pro His Ala His Gly Tyr Ile Pro Ser Lys Phe 
        115                 120                 125             


Pro Asn Lys Asn Leu Lys Lys Asn Tyr Cys Arg Asn Pro Asp Arg Glu 
    130                 135                 140                 


Leu Arg Pro Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Leu 
145                 150                 155                 160 


Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Ser Ser Gly Pro Thr 
                165                 170                 175     


Tyr Gln Cys Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly Asn Val Ala 
            180                 185                 190         


Val Thr Val Ser Gly His Thr Cys Gln His Trp Ser Ala Gln Thr Pro 
        195                 200                 205             


His Thr His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Asp 
    210                 215                 220                 


Glu Asn Tyr Cys Arg Asn Pro Asp Gly Lys Arg Ala Pro Trp Cys His 
225                 230                 235                 240 


Thr Thr Asn Ser Gln Val Arg Trp Glu Tyr Cys Lys Ile Pro Ser Cys 
                245                 250                 255     


Asp Ser Ser Pro Val Ser Thr Glu Gln Leu Ala Pro Thr Ala Pro Pro 
            260                 265                 270         


Glu Leu Thr Pro Val Val Gln Asp Cys Tyr His Gly Asp Gly Gln Ser 
        275                 280                 285             


Tyr Arg Gly Thr Ser Ser Thr Thr Thr Thr Gly Lys Lys Cys Gln Ser 
    290                 295                 300                 


Trp Ser Ser Met Thr Pro His Arg His Gln Lys Thr Pro Glu Asn Tyr 
305                 310                 315                 320 


Pro Asn Ala Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp 
                325                 330                 335     


Lys Gly Pro Trp Cys Phe Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr 
            340                 345                 350         


Cys Asn Leu Lys Lys Cys Ser Gly Thr Glu Ala Ser Val Val Ala Pro 
        355                 360                 365             


Pro Pro Val Val Leu Leu Pro Asp Val Glu Thr Pro Ser Glu Glu Asp 
    370                 375                 380                 


Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys Arg Ala Thr Thr 
385                 390                 395                 400 


Val Thr Gly Thr Pro Cys Gln Asp Trp Ala Ala Gln Glu Pro His Arg 
                405                 410                 415     


His Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys 
            420                 425                 430         


Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Cys Tyr 
        435                 440                 445             


Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro Gln Cys 
    450                 455                 460                 


Ala Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys 
465                 470                 475                 480 


Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro His Ser Trp 
                485                 490                 495     


Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met His Phe Cys Gly 
            500                 505                 510         


Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu 
        515                 520                 525             


Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His 
    530                 535                 540                 


Gln Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg 
545                 550                 555                 560 


Leu Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys Leu Ser 
                565                 570                 575     


Ser Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser 
            580                 585                 590         


Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp 
        595                 600                 605             


Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln 
    610                 615                 620                 


Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn 
625                 630                 635                 640 


Gly Arg Val Gln Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly 
                645                 650                 655     


Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu 
            660                 665                 670         


Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys 
        675                 680                 685             


Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val 
    690                 695                 700                 


Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
705                 710                 


<210>  18
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  18

Asp Cys Tyr His Gly Asp Gly Gln Ser Tyr Arg Gly Thr Ser Ser Thr 
1               5                   10                  15      


Thr Thr Thr Gly Lys Lys Cys Gln Ser Trp Ser Ser Met Thr Pro His 
            20                  25                  30          


Arg His Gln Lys Thr Pro Glu Asn Tyr Pro Asn Ala Gly Leu Thr Met 
        35                  40                  45              


Asn Tyr Cys Arg Asn Pro Asp Ala Asp Lys Gly Pro Trp Cys Phe Thr 
    50                  55                  60                  


Thr Asp Pro Ser Val Arg Trp Glu Tyr Cys Asn Leu Lys Lys Cys Ser 
65                  70                  75                  80  


Gly Thr Glu Ala Ser Val Val Ala Pro Pro Pro Val Val Leu Leu Pro 
                85                  90                  95      


Asp Val Glu Thr Pro Ser Glu Glu Asp Cys Met Phe Gly Asn Gly Lys 
            100                 105                 110         


Gly Tyr Arg Gly Lys Arg Ala Thr Thr Val Thr Gly Thr Pro Cys Gln 
        115                 120                 125             


Asp Trp Ala Ala Gln Glu Pro His Arg His Ser Ile Phe Thr Pro Glu 
    130                 135                 140                 


Thr Asn Pro Arg Ala Gly Leu Glu Lys Asn Tyr Cys Arg Asn Pro Asp 
145                 150                 155                 160 


Gly Asp Val Gly Gly Pro Trp Cys Tyr Thr Thr Asn Pro Arg Lys Leu 
                165                 170                 175     


Tyr Asp Tyr Cys Asp Val Pro Gln Cys Ala Ala Pro Ser Phe Asp Cys 
            180                 185                 190         


Gly Lys Pro Gln Val Glu Pro Lys Lys Cys Pro Gly Arg Val Val Gly 
        195                 200                 205             


Gly Cys Val Ala His Pro His Ser Trp Pro Trp Gln Val Ser Leu Arg 
    210                 215                 220                 


Thr Arg Phe Gly Met His Phe Cys Gly Gly Thr Leu Ile Ser Pro Glu 
225                 230                 235                 240 


Trp Val Leu Thr Ala Ala His Cys Leu Glu Lys Ser Pro Arg Pro Ser 
                245                 250                 255     


Ser Tyr Lys Val Ile Leu Gly Ala His Gln Glu Val Asn Leu Glu Pro 
            260                 265                 270         


His Val Gln Glu Ile Glu Val Ser Arg Leu Phe Leu Glu Pro Thr Arg 
        275                 280                 285             


Lys Asp Ile Ala Leu Leu Lys Leu Ser Ser Pro Ala Val Ile Thr Asp 
    290                 295                 300                 


Lys Val Ile Pro Ala Cys Leu Pro Ser Pro Asn Tyr Val Val Ala Asp 
305                 310                 315                 320 


Arg Thr Glu Cys Phe Ile Thr Gly Trp Gly Glu Thr Gln Gly Thr Phe 
                325                 330                 335     


Gly Ala Gly Leu Leu Lys Glu Ala Gln Leu Pro Val Ile Glu Asn Lys 
            340                 345                 350         


Val Cys Asn Arg Tyr Glu Phe Leu Asn Gly Arg Val Gln Ser Thr Glu 
        355                 360                 365             


Leu Cys Ala Gly His Leu Ala Gly Gly Thr Asp Ser Cys Gln Gly Asp 
    370                 375                 380                 


Ser Gly Gly Pro Leu Val Cys Phe Glu Lys Asp Lys Tyr Ile Leu Gln 
385                 390                 395                 400 


Gly Val Thr Ser Trp Gly Leu Gly Cys Ala Arg Pro Asn Lys Pro Gly 
                405                 410                 415     


Val Tyr Val Arg Val Ser Arg Phe Val Thr Trp Ile Glu Gly Val Met 
            420                 425                 430         


Arg Asn Asn 
        435 


<210>  19
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  19

Glu Asp Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys Arg Ala 
1               5                   10                  15      


Thr Thr Val Thr Gly Thr Pro Cys Gln Asp Trp Ala Ala Gln Glu Pro 
            20                  25                  30          


His Arg His Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu 
        35                  40                  45              


Glu Lys Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp 
    50                  55                  60                  


Cys Tyr Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro 
65                  70                  75                  80  


Gln Cys Ala Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro 
                85                  90                  95      


Lys Lys Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro His 
            100                 105                 110         


Ser Trp Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met His Phe 
        115                 120                 125             


Cys Gly Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His 
    130                 135                 140                 


Cys Leu Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly 
145                 150                 155                 160 


Ala His Gln Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu Val 
                165                 170                 175     


Ser Arg Leu Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys 
            180                 185                 190         


Leu Ser Ser Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu 
        195                 200                 205             


Pro Ser Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr 
    210                 215                 220                 


Gly Trp Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu 
225                 230                 235                 240 


Ala Gln Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe 
                245                 250                 255     


Leu Asn Gly Arg Val Gln Ser Thr Glu Leu Cys Ala Gly His Leu Ala 
            260                 265                 270         


Gly Gly Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys 
        275                 280                 285             


Phe Glu Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu 
    290                 295                 300                 


Gly Cys Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg 
305                 310                 315                 320 


Phe Val Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
                325                 330         


<210>  20
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  20

Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys Cys 
1               5                   10                  15      


Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro His Ser Trp Pro 
            20                  25                  30          


Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met His Phe Cys Gly Gly 
        35                  40                  45              


Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu Glu 
    50                  55                  60                  


Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His Gln 
65                  70                  75                  80  


Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg Leu 
                85                  90                  95      


Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys Leu Ser Ser 
            100                 105                 110         


Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser Pro 
        115                 120                 125             


Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp Gly 
    130                 135                 140                 


Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln Leu 
145                 150                 155                 160 


Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn Gly 
                165                 170                 175     


Arg Val Gln Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly Thr 
            180                 185                 190         


Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu Lys 
        195                 200                 205             


Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys Ala 
    210                 215                 220                 


Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val Thr 
225                 230                 235                 240 


Trp Ile Glu Gly Val Met Arg Asn Asn 
                245                 


