                               SEQUENCE LISTING

<110> IMCARE BIOTECH, LLC.
 
<120> ANTI-SERINE PROTEASE INHIBITOR KAZAL (SPIK) ANTIBODIES, 
      IMMUNOCONJUGATES, AND METHODS OF USE

<130> IMC-0002-WO

<140> PCT/US2020/041228
<141> 2020-07-08

<150> 62/871,565
<151> 2019-07-08

<160> 113   

<170> PatentIn version 3.5

<210> 1
<211> 151
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1
Leu Val Ala Val Leu Lys Gly Val Gln Cys Gln Ser Val Lys Glu Ser 
1               5                   10                  15      


Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr Leu Thr Leu Thr Cys Thr 
            20                  25                  30          


Val Ser Gly Phe Ser Leu Ser Ser Asn Ala Ile Ser Trp Val Arg Gln 
        35                  40                  45              


Ala Pro Gly Asn Gly Leu Glu Trp Ile Gly Ala Ile Gly Ser Ser Gly 
    50                  55                  60                  


Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Ser Arg Ser Thr Val Thr Arg 
65                  70                  75                  80  


Asn Thr Asn Leu Asn Thr Val Thr Leu Lys Met Thr Ser Leu Thr Ala 
                85                  90                  95      


Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg Trp Glu Asn Ile Gly Tyr 
            100                 105                 110         


Thr Asn Val Arg Leu Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys 
    130                 135                 140                 


Cys Gly Asp Thr Pro Ser Ser 
145                 150     


<210> 2
<211> 148
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Val Ala Val Leu Lys Gly Val Gln Cys Gln Ser Val Lys Glu Ser Glu 
1               5                   10                  15      


Gly Gly Leu Phe Lys Pro Thr Asp Thr Leu Thr Leu Thr Cys Thr Val 
            20                  25                  30          


Ser Gly Phe Ser Leu Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
        35                  40                  45              


Pro Gly Asn Gly Leu Glu Trp Ile Gly Arg Ile Asn Ser Gly Gly Ala 
    50                  55                  60                  


Thr Asp Tyr Ala Ser Trp Ala Arg Ser Arg Ser Thr Ile Thr Arg Asp 
65                  70                  75                  80  


Thr Asn Leu Asn Thr Val Thr Leu Gln Met Thr Ser Leu Thr Ala Ala 
                85                  90                  95      


Asp Thr Ala Thr Tyr Phe Cys Ala Lys Glu Glu Tyr Ser Tyr Gly Gly 
            100                 105                 110         


Ala Tyr Gly Met Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly Asp 
    130                 135                 140                 


Thr Pro Ser Ser 
145             


<210> 3
<211> 135
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 3
Leu Val Ala Val Leu Lys Gly Val Gln Cys Gln Ser Val Lys Glu Ser 
1               5                   10                  15      


Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr Leu Thr Leu Thr Cys Thr 
            20                  25                  30          


Val Ser Gly Phe Ser Leu Ser Ser Tyr Gly Val Ser Trp Val Arg Gln 
        35                  40                  45              


Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Trp Ser Gly Gly 
    50                  55                  60                  


Thr Thr Asp Tyr Ala Ser Trp Ala Lys Ser Arg Ser Thr Ile Thr Arg 
65                  70                  75                  80  


Asn Thr Asn Glu Asn Thr Val Thr Leu Lys Val Thr Ser Leu Thr Ala 
                85                  90                  95      


Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Gly Tyr Asp Tyr Gly 
            100                 105                 110         


Tyr Ala Ser Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Gly Gln Pro Lys Ala Pro Ser 
    130                 135 


<210> 4
<211> 153
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 4
Leu Val Ala Val Leu Lys Gly Val Gln Cys Gln Ser Val Lys Glu Ser 
1               5                   10                  15      


Glu Gly Gly Leu Phe Lys Pro Thr Asp Ala Leu Thr Leu Thr Cys Thr 
            20                  25                  30          


Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln 
        35                  40                  45              


Ala Pro Gly Ser Gly Leu Glu Trp Ile Gly Ala Ile Asn Thr Tyr Gly 
    50                  55                  60                  


Gly Thr Tyr Tyr Ala Ser Trp Ala Lys Ser Arg Ser Thr Ile Thr Arg 
65                  70                  75                  80  


Asn Thr Asn Glu Asn Thr Val Thr Leu Lys Met Thr Ser Leu Thr Ala 
                85                  90                  95      


Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asp Phe Asp Ser Asp Ala 
            100                 105                 110         


Tyr Thr Ser Ala Ser Gly Gly Met Asp Pro Trp Gly Pro Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gln Pro Lys Ala Pro Ser Phe Phe Pro Leu 
    130                 135                 140                 


Ala Pro Cys Cys Gly Asp Thr Pro Arg 
145                 150             


<210> 5
<211> 149
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Val Ala Val Leu Lys Gly Val Gln Cys Gln Ser Val Lys Glu Ser Glu 
1               5                   10                  15      


Gly Gly Leu Phe Lys Pro Thr Asp Thr Leu Thr Leu Thr Cys Thr Val 
            20                  25                  30          


Ser Gly Phe Ser Leu Ser Ser Tyr Ala Ile Gly Trp Val Arg Gln Ala 
        35                  40                  45              


Pro Gly Asn Gly Leu Glu Trp Ile Gly Thr Ile Val Thr Ser Gly Ile 
    50                  55                  60                  


Pro Tyr Tyr Ala Asn Trp Ala Lys Ser Arg Ser Thr Ile Thr Arg Asn 
65                  70                  75                  80  


Thr Asn Leu Asn Thr Val Thr Leu Lys Met Thr Ser Leu Thr Ala Ala 
                85                  90                  95      


Asp Thr Ala Thr Tyr Phe Cys Ala Arg Asn Leu Asp Pro Ala Tyr Ser 
            100                 105                 110         


Thr Thr Arg Leu Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys 
    130                 135                 140                 


Gly Asp Thr Pro Ser 
145                 


<210> 6
<211> 149
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Val Ala Val Leu Lys Gly Val Gln Cys Gln Ser Val Lys Glu Ser Glu 
1               5                   10                  15      


Gly Gly Leu Phe Lys Pro Thr Asp Thr Leu Thr Leu Thr Cys Thr Val 
            20                  25                  30          


Ser Gly Phe Ser Leu Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala 
        35                  40                  45              


Pro Gly Asn Gly Leu Glu Trp Ile Gly Ala Ile Gly Lys Ser Gly Ser 
    50                  55                  60                  


Ala Tyr Tyr Ala Ser Trp Ala Lys Ser Arg Ser Thr Ile Thr Arg Asn 
65                  70                  75                  80  


Thr Asn Leu Asn Thr Val Ser Leu Lys Met Thr Ser Leu Thr Ala Ala 
                85                  90                  95      


Asp Thr Ala Thr Tyr Phe Cys Ala Arg Trp Asp Ser Val Gly Trp Thr 
            100                 105                 110         


Asp Ala Arg Leu Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys 
    130                 135                 140                 


Gly Asp Thr Pro Ser 
145                 


<210> 7
<211> 136
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 7
Leu Val Ala Val Leu Lys Gly Val Gln Cys Gln Ser Val Lys Glu Ser 
1               5                   10                  15      


Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr Leu Thr Leu Thr Cys Thr 
            20                  25                  30          


Val Ser Gly Phe Ser Leu Ser Ala Tyr Ala Ile Ser Trp Val Arg Gln 
        35                  40                  45              


Ala Pro Gly Asn Gly Leu Glu Trp Ile Gly Ala Ile Asn Ser Gly Gly 
    50                  55                  60                  


Ser Ala Tyr Tyr Ala Asn Trp Ala Lys Ser Arg Ser Thr Ile Thr Arg 
65                  70                  75                  80  


Asn Thr Asn Leu Asn Thr Val Thr Leu Lys Met Thr Ser Leu Thr Ala 
                85                  90                  95      


Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Asp Ile Tyr Asp Tyr 
            100                 105                 110         


Gly Gly Ala Phe Asp Pro Trp Gly Pro Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Thr Gly Gln Pro Lys Leu His His 
    130                 135     


<210> 8
<211> 147
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Val Ala Val Leu Lys Gly Val Gln Cys Gln Ser Val Lys Glu Ser Glu 
1               5                   10                  15      


Gly Gly Leu Phe Lys Pro Thr Asp Thr Leu Thr Leu Thr Cys Thr Val 
            20                  25                  30          


Ser Gly Phe Ser Leu Ser Ile Tyr Gly Val Ser Trp Val Arg Gln Ala 
        35                  40                  45              


Pro Gly Asn Gly Leu Glu Trp Ile Gly Ile Ile Tyr Ala Ser Gly Ser 
    50                  55                  60                  


Ala Asp Tyr Ala Ser Trp Ala Lys Ser Arg Ser Thr Ile Thr Arg Asn 
65                  70                  75                  80  


Thr Asn Leu Asn Thr Val Thr Leu Lys Met Thr Ser Leu Thr Ala Ala 
                85                  90                  95      


Asp Thr Ala Thr Tyr Phe Cys Ala Arg Glu Asp Asp Thr Tyr Gly Tyr 
            100                 105                 110         


Thr Ser Ser Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly Asp 
    130                 135                 140                 


Thr Pro Ser 
145         


<210> 9
<211> 146
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 9
Leu Val Ala Val Leu Lys Gly Val Gln Cys Gln Ser Val Lys Glu Ser 
1               5                   10                  15      


Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr Leu Thr Leu Thr Cys Thr 
            20                  25                  30          


Val Ser Gly Phe Ser Leu Ser Ser Tyr Pro Ile Ser Trp Val Arg Gln 
        35                  40                  45              


Ala Pro Gly Asn Gly Leu Glu Trp Ile Gly Asp Ile Tyr Ala Ser Gly 
    50                  55                  60                  


Ser Ile Leu Tyr Ala Ser Trp Ala Thr Gly Arg Ser Thr Ile Thr Arg 
65                  70                  75                  80  


Asn Thr Asn Leu Asn Thr Val Thr Leu Lys Met Thr Ser Leu Thr Ala 
                85                  90                  95      


Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg Val Ser Tyr Ser Gly Gly 
            100                 105                 110         


Thr Asp Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gln 
        115                 120                 125             


Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly Asp Thr 
    130                 135                 140                 


Pro Ser 
145     


<210> 10
<211> 148
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 10
Leu Val Ala Val Leu Lys Gly Val Gln Cys Gln Ser Val Lys Glu Ser 
1               5                   10                  15      


Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr Leu Thr Leu Thr Cys Thr 
            20                  25                  30          


Val Ser Gly Phe Ser Leu Ser Ser Asn Val Ile Ser Trp Val Arg Gln 
        35                  40                  45              


Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Asp Ile Tyr Val Ser Gly 
    50                  55                  60                  


Asn Thr Asp Tyr Ala Ser Trp Ala Lys Ser Arg Ser Thr Ile Thr Arg 
65                  70                  75                  80  


Asn Ala Asn Leu Asn Thr Val Thr Leu Lys Met Thr Ser Leu Thr Ala 
                85                  90                  95      


Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg Tyr Asp Met Ser Ser Asp 
            100                 105                 110         


Ala Phe Asp Pro Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly Asp 
    130                 135                 140                 


Thr Pro Ser Ser 
145             


<210> 11
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 11
Trp Leu Pro Gly Ala Arg Cys Ala Tyr Asp Met Thr Gln Thr Pro Ala 
1               5                   10                  15      


Ser Val Glu Val Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala 
            20                  25                  30          


Ser Gln Ser Ile Ser Thr Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
        35                  40                  45              


Gln Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly 
    50                  55                  60                  


Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu 
65                  70                  75                  80  


Thr Ile Ser Gly Val Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln 
                85                  90                  95      


Gln Gly Tyr Ser Thr Ser Asp Val Asp Asn Ala Phe Gly Gly Gly Thr 
            100                 105                 110         


Glu Gly 
        


<210> 12
<211> 134
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 12
Leu Trp Leu Pro Gly Ala Arg Cys Ala Tyr Asp Met Thr Gln Thr Pro 
1               5                   10                  15      


Ala Ser Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln 
            20                  25                  30          


Ala Ser Glu Ser Ile Ser Thr Tyr Leu Ser Trp Leu Gln Gln Lys Pro 
        35                  40                  45              


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser 
    50                  55                  60                  


Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr 
65                  70                  75                  80  


Leu Thr Ile Ser Gly Val Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Gln Gln Asp Tyr Thr Ile Ser Asn Val Gly Asn Val Phe Gly Gly Gly 
            100                 105                 110         


Thr Glu Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile 
        115                 120                 125             


Phe Pro Pro Ser Ala Asp 
    130                 


<210> 13
<211> 134
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 13
Leu Trp Leu Pro Gly Ala Arg Cys Ala Tyr Asp Met Thr Gln Thr Pro 
1               5                   10                  15      


Ala Ser Val Glu Val Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln 
            20                  25                  30          


Ala Ser Glu Ser Ile Ser Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro 
        35                  40                  45              


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser 
    50                  55                  60                  


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
65                  70                  75                  80  


Leu Thr Ile Ser Asp Gly Gln Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Gln Gln Gly Tyr Ser Val Ser Asn Val Asp Asn Ile Phe Gly Gly Gly 
            100                 105                 110         


Thr Glu Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile 
        115                 120                 125             


Phe Pro Pro Ser Ala Asp 
    130                 


<210> 14
<211> 132
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 14
Trp Leu Pro Gly Ala Arg Cys Ala Tyr Asp Met Thr Gln Thr Pro Ala 
1               5                   10                  15      


Ser Val Glu Val Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala 
            20                  25                  30          


Ser Gln Ser Ile Asn Asn Tyr Leu Ser Trp Tyr Gln Gln Ile Pro Gly 
        35                  40                  45              


Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly 
    50                  55                  60                  


Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu 
65                  70                  75                  80  


Thr Ile Ser Gly Val Gln Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln 
                85                  90                  95      


Gln Gly Tyr Thr Ser Asn Val Asp Asn Val Phe Gly Gly Gly Thr Glu 
            100                 105                 110         


Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro 
        115                 120                 125             


Pro Ser Ala Asp 
    130         


<210> 15
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 15
Trp Leu Pro Gly Ala Arg Cys Ala Tyr Asp Met Thr Gln Thr Pro Ala 
1               5                   10                  15      


Ser Val Ser Glu Pro Val Arg Gly Thr Val Thr Ile Lys Cys Gln Ala 
            20                  25                  30          


Ser Gln Ser Ile Ser Thr Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
        35                  40                  45              


Gln Pro Pro Lys Leu Leu Ile Tyr Ala Ala Ser Tyr Leu Ala Ser Gly 
    50                  55                  60                  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
65                  70                  75                  80  


Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys His 
                85                  90                  95      


Gln Gly Tyr Ser Ala Ser Asn Val Asp Asn Thr Phe Gly Gly Gly Thr 
            100                 105                 110         


Glu Gly Gly Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe 
        115                 120                 125             


Pro Pro 
    130 


<210> 16
<211> 133
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
Trp Leu Pro Gly Ala Arg Cys Ala Tyr Asp Met Thr Gln Thr Pro Ala 
1               5                   10                  15      


Ser Val Glu Val Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala 
            20                  25                  30          


Ser Gln Ser Ile Ser Thr Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
        35                  40                  45              


Gln Arg Pro Lys Leu Leu Ile Tyr Gly Ala Ser Lys Leu Ala Ser Gly 
    50                  55                  60                  


Val Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
65                  70                  75                  80  


Thr Ile Ser Gly Val Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln 
                85                  90                  95      


Gln Gly Tyr Glu Thr Ser Asn Val Asp Asn Ala Phe Gly Gly Gly Thr 
            100                 105                 110         


Glu Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe 
        115                 120                 125             


Pro Pro Ser Ala Asp 
    130             


<210> 17
<211> 133
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 17
Trp Leu Pro Gly Ala Arg Cys Ala Tyr Asp Met Thr Gln Thr Pro Ala 
1               5                   10                  15      


Ser Val Glu Val Thr Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala 
            20                  25                  30          


Ser Gln Gly Ile Ser Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly 
        35                  40                  45              


Gln Pro Pro Lys Leu Leu Ile Tyr Ala Ala Thr Thr Leu Val Ser Gly 
    50                  55                  60                  


Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu 
65                  70                  75                  80  


Thr Ile Ser Gly Val Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln 
                85                  90                  95      


Gln Asp Tyr Thr Thr Ser Asn Val Asp Asn Thr Phe Gly Gly Gly Thr 
            100                 105                 110         


Glu Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe 
        115                 120                 125             


Pro Pro Ser Ala Asp 
    130             


<210> 18
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 18
Trp Leu Pro Gly Ala Arg Cys Ala Tyr Asp Met Thr Gln Thr Pro Ala 
1               5                   10                  15      


Ser Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala 
            20                  25                  30          


Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
        35                  40                  45              


Gln Pro Pro Lys Arg Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly 
    50                  55                  60                  


Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu 
65                  70                  75                  80  


Thr Ile Ser Gly Val Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln 
                85                  90                  95      


Gln Asp Tyr Ser Ser Asn Asn Ile Asp Asn Thr Phe Gly Gly Gly Thr 
            100                 105                 110         


Glu Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe 
        115                 120                 125             


Pro Pro 
    130 


<210> 19
<211> 130
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 19
Trp Leu Pro Gly Ala Arg Cys Ala Tyr Asp Met Thr Gln Thr Pro Ala 
1               5                   10                  15      


Ser Val Glu Val Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala 
            20                  25                  30          


Ser Glu Asp Ile Glu Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
        35                  40                  45              


Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Thr Leu Pro Ser Gly 
    50                  55                  60                  


Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
65                  70                  75                  80  


Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys Gln 
                85                  90                  95      


Gln Asp Tyr Ser Ser Ser Asn Val Asp Asn Thr Phe Gly Gly Gly Thr 
            100                 105                 110         


Glu Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe 
        115                 120                 125             


Pro Pro 
    130 


<210> 20
<211> 133
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 20
Leu Trp Leu Pro Gly Ala Arg Cys Ala Tyr Asp Met Thr Gln Thr Pro 
1               5                   10                  15      


Ala Ser Val Glu Val Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln 
            20                  25                  30          


Ala Ser Gln Asn Ile Gly Ser Tyr Leu Ser Trp Tyr Gln His Lys Pro 
        35                  40                  45              


Gly Gln Arg Pro Arg Leu Leu Met Tyr Arg Ala Ser Thr Leu Ala Ser 
    50                  55                  60                  


Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr 
65                  70                  75                  80  


Leu Thr Ile Ser Gly Val Gln Cys Asp Asn Ala Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Gln Gln Gly Tyr Thr Asn Ser Gly Val Asp Asn Thr Phe Gly Gly Gly 
            100                 105                 110         


Thr Glu Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile 
        115                 120                 125             


Phe Pro Pro Ser Ala 
    130             


<210> 21
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 21
Ser Ser Asn Ala Ile Ser 
1               5       


<210> 22
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 22
Ser Ser Tyr Ala Ile Ser 
1               5       


<210> 23
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 23
Ser Ser Tyr Gly Val Ser 
1               5       


<210> 24
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 24
Ser Ser Tyr Ala Ile Ser 
1               5       


<210> 25
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 25
Ser Ser Tyr Ala Ile Gly 
1               5       


<210> 26
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 26
Ser Ser Tyr Ala Ile Ser 
1               5       


<210> 27
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 27
Ser Ala Tyr Ala Ile Ser 
1               5       


<210> 28
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 28
Ser Ile Tyr Gly Val Ser 
1               5       


<210> 29
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 29
Ser Ser Tyr Pro Ile Ser 
1               5       


<210> 30
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 30
Ser Ser Asn Val Ile Ser 
1               5       


<210> 31
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 31
Ala Ile Gly Ser Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
1               5                   10                  15      


<210> 32
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 32
Arg Ile Asn Ser Gly Gly Ala Thr Asp Tyr Ala Ser Trp Ala Arg Ser 
1               5                   10                  15      


<210> 33
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 33
Ser Ile Trp Ser Gly Gly Thr Thr Asp Tyr Ala Ser Trp Ala Lys Ser 
1               5                   10                  15      


<210> 34
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 34
Ala Ile Asn Thr Tyr Gly Gly Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
1               5                   10                  15      


<210> 35
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 35
Thr Ile Val Thr Ser Gly Ile Pro Tyr Tyr Ala Asn Trp Ala Lys Ser 
1               5                   10                  15      


<210> 36
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 36
Ala Ile Gly Lys Ser Gly Ser Ala Tyr Tyr Ala Ser Trp Ala Lys Ser 
1               5                   10                  15      


<210> 37
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 37
Ala Ile Asn Ser Gly Gly Ser Ala Tyr Tyr Ala Asn Trp Ala Lys Ser 
1               5                   10                  15      


<210> 38
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 38
Ile Ile Tyr Ala Ser Gly Ser Ala Asp Tyr Ala Ser Trp Ala Lys Ser 
1               5                   10                  15      


<210> 39
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 39
Asp Ile Tyr Ala Ser Gly Ser Ile Leu Tyr Ala Ser Trp Ala Thr Gly 
1               5                   10                  15      


<210> 40
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 40
Asp Ile Tyr Val Ser Gly Asn Thr Asp Tyr Ala Ser Trp Ala Lys Ser 
1               5                   10                  15      


<210> 41
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 41
Arg Trp Glu Asn Ile Gly Tyr Thr Asn Val Arg Leu Asp Leu 
1               5                   10                  


<210> 42
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 42
Lys Glu Glu Tyr Ser Tyr Gly Gly Ala Tyr Gly Met 
1               5                   10          


<210> 43
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 43
Arg Gly Gly Tyr Asp Tyr Gly Tyr Ala Ser Asn Ile 
1               5                   10          


<210> 44
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 44
Arg Asp Phe Asp Ser Asp Ala Tyr Thr Ser Ala Ser Gly Gly Met Asp 
1               5                   10                  15      


Pro 
    


<210> 45
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 45
Arg Asn Leu Asp Pro Ala Tyr Ser Thr Thr Arg Leu Asp Leu 
1               5                   10                  


<210> 46
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 46
Arg Trp Asp Ser Val Gly Trp Thr Asp Ala Arg Leu Asp Leu 
1               5                   10                  


<210> 47
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 47
Arg Glu Asp Ile Tyr Asp Tyr Gly Gly Ala Phe Asp Pro 
1               5                   10              


<210> 48
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 48
Arg Glu Asp Asp Thr Tyr Gly Tyr Thr Ser Ser Ile 
1               5                   10          


<210> 49
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 49
Arg Val Ser Tyr Ser Gly Gly Thr Asp Ile 
1               5                   10  


<210> 50
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 50
Arg Tyr Asp Met Ser Ser Asp Ala Phe Asp Pro 
1               5                   10      


<210> 51
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 51
Gln Ala Ser Gln Ser Ile Ser Thr Ala Leu Ala 
1               5                   10      


<210> 52
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 52
Gln Ala Ser Glu Ser Ile Ser Thr Tyr Leu Ser 
1               5                   10      


<210> 53
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 53
Gln Ala Ser Glu Ser Ile Ser Ser Tyr Leu Ser 
1               5                   10      


<210> 54
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 54
Gln Ala Ser Gln Ser Ile Asn Asn Tyr Leu Ser 
1               5                   10      


<210> 55
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 55
Gln Ala Ser Gln Ser Ile Ser Thr Ala Leu Ala 
1               5                   10      


<210> 56
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 56
Gln Ala Ser Gln Ser Ile Ser Thr Ala Leu Ala 
1               5                   10      


<210> 57
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 57
Gln Ala Ser Gln Gly Ile Ser Ser Tyr Leu Ser 
1               5                   10      


<210> 58
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 58
Gln Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210> 59
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 59
Gln Ala Ser Glu Asp Ile Glu Ser Tyr Leu Ala 
1               5                   10      


<210> 60
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 60
Gln Ala Ser Gln Asn Ile Gly Ser Tyr Leu Ser 
1               5                   10      


<210> 61
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 61
Gly Ala Ser Thr Leu Ala Ser 
1               5           


<210> 62
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 62
Lys Ala Ser Thr Leu Ala Ser 
1               5           


<210> 63
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 63
Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210> 64
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 64
Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210> 65
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 65
Ala Ala Ser Tyr Leu Ala Ser 
1               5           


<210> 66
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 66
Gly Ala Ser Lys Leu Ala Ser 
1               5           


<210> 67
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 67
Ala Ala Thr Thr Leu Val Ser 
1               5           


<210> 68
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 68
Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210> 69
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 69
Arg Ala Ser Thr Leu Pro Ser 
1               5           


<210> 70
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 70
Arg Ala Ser Thr Leu Ala Ser 
1               5           


<210> 71
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 71
Gln Gln Gly Tyr Ser Thr Ser Asp Val Asp Asn Ala 
1               5                   10          


<210> 72
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 72
Gln Gln Asp Tyr Thr Ile Ser Asn Val Gly Asn Val 
1               5                   10          


<210> 73
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 73
Gln Gln Gly Tyr Ser Val Ser Asn Val Asp Asn Ile 
1               5                   10          


<210> 74
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 74
Gln Gln Gly Tyr Thr Ser Asn Val Asp Asn Val Phe 
1               5                   10          


<210> 75
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 75
His Gln Gly Tyr Ser Ala Ser Asn Val Asp Asn Thr 
1               5                   10          


<210> 76
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 76
Gln Gln Gly Tyr Glu Thr Ser Asn Val Asp Asn Ala 
1               5                   10          


<210> 77
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 77
Gln Gln Asp Tyr Thr Thr Ser Asn Val Asp Asn Thr 
1               5                   10          


<210> 78
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 78
Gln Gln Asp Tyr Ser Ser Asn Asn Ile Asp Asn Thr 
1               5                   10          


<210> 79
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 79
Gln Gln Asp Tyr Ser Ser Ser Asn Val Asp Asn Thr 
1               5                   10          


<210> 80
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 80
Gln Gln Gly Tyr Thr Asn Ser Gly Val Asp Asn Thr 
1               5                   10          


<210> 81
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 81
Met Lys Val Thr Gly Ile Phe Leu Leu Ser Ala Leu Ala Leu Leu Ser 
1               5                   10                  15      


Leu Ser Gly Asn Thr Gly Ala 
            20              


<210> 82
<211> 79
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 82
Met Lys Val Thr Gly Ile Phe Leu Leu Ser Ala Leu Ala Leu Leu Ser 
1               5                   10                  15      


Leu Ser Gly Asn Thr Gly Ala Asp Ser Leu Gly Arg Glu Ala Lys Cys 
            20                  25                  30          


Tyr Asn Glu Leu Asn Gly Cys Thr Lys Ile Tyr Asp Pro Val Cys Gly 
        35                  40                  45              


Thr Asp Gly Asn Thr Tyr Pro Asn Glu Cys Val Leu Cys Phe Glu Asn 
    50                  55                  60                  


Arg Lys Arg Gln Thr Ser Ile Leu Ile Gln Lys Ser Gly Pro Cys 
65                  70                  75                  


<210> 83
<211> 56
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 83
Asp Ser Leu Gly Arg Glu Ala Lys Cys Tyr Asn Glu Leu Asn Gly Cys 
1               5                   10                  15      


Thr Lys Ile Tyr Asp Pro Val Cys Gly Thr Asp Gly Asn Thr Tyr Pro 
            20                  25                  30          


Asn Glu Cys Val Leu Cys Phe Glu Asn Arg Lys Arg Gln Thr Ser Ile 
        35                  40                  45              


Leu Ile Gln Lys Ser Gly Pro Cys 
    50                  55      


<210> 84
<211> 453
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 84
ctggtcgctg tgctcaaagg tgtccagtgt cagtcggtga aggagtccga gggaggtctc       60

ttcaagccaa cggataccct gacactcacc tgcacagtct ctggattctc cctcagtagc      120

aatgcaataa gctgggtccg ccaggctcca gggaacgggc tggaatggat cggagccatt      180

ggtagtagtg gtagcacata ctacgcgagc tgggcgaaaa gccgatccac cgtcaccaga      240

aacaccaacc tgaacacggt gactctaaag atgaccagtc tgacagccgc ggacacggcc      300

acctatttct gtgcgagatg ggagaatatt ggttatacta atgttcggtt ggatctctgg      360

ggccagggca ccctggtcac cgtctcctca gggcaaccta aggctccatc agtcttccca      420

ctggccccct gctgcgggga cacacccagc tcc                                   453


<210> 85
<211> 343
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 85
tggctcccag gtgccagatg tgcctatgat atgacccaga ctccagcctc tgtggaggta       60

gctgtgggag gcacagtcac catcaagtgc caggccagtc agagcattag cactgcatta      120

gcctggtatc agcagaaacc agggcagcct cccaagctcc tgatctatgg tgcatccact      180

ctggcatctg gggtctcatc gcggttcaaa ggcagtggat ctgggacaca gttcactctc      240

accatcagcg gcgtggagtg tgccgatgct gccacttact actgtcaaca gggttatagt      300

actagtgatg ttgataatgc tttcggcgga gggaccgagg ggg                        343


<210> 86
<211> 445
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 86
ggtcgctgtg ctcaaaggtg tccagtgtca gtcggtgaag gagtccgagg gaggtctctt       60

caagccaacg gataccctga cactcacctg cacagtctct ggattctccc tcagtagcta      120

tgcaataagt tgggtccgcc aggctccagg gaacgggctg gaatggatcg ggcgcattaa      180

tagtggtggt gccacagact acgcgagctg ggcgagaagc cgatccacca tcaccagaga      240

caccaacctg aacacggtga ctctgcaaat gaccagtctg accgccgcgg acacggccac      300

ctatttctgt gcgaaagaag agtatagtta tggtggtgct tatggtatgt ggggcccagg      360

cactctggtc accgtctcct cagggcaacc taaggctcca tcagtcttcc cactggcccc      420

ctgctgcggg gacacaccca gctcc                                            445


<210> 87
<211> 404
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 87
ctctggctcc caggtgccag atgtgcctat gatatgaccc agactccagc ctccgtgtct       60

gcagctgtgg gaggcacagt caccatcaag tgccaggcca gtgagagcat tagtacctac      120

ttatcctggt tgcagcagaa accagggcag cctcccaagc tcctgatcta caaggcttcc      180

actctggcat ctggggtccc atcgcggttc aaaggcagtg gatctgggac agagttcact      240

ctcaccatca gcggtgtgca gtgtgacgat gctgccactt actactgtca acaggattat      300

actattagta atgttggtaa tgttttcggc ggagggaccg aggtggtggt caaaggtgat      360

ccagttgcac ctactgtcct catcttccca ccatcagcgg acca                       404


<210> 88
<211> 406
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 88
cctggtcgct gtgctcaaag gtgtccagtg tcagtcggtg aaggagtccg agggaggtct       60

cttcaagcca acggataccc tgacactcac ctgcacagtc tctggattct ccctcagtag      120

ttatggagtg agctgggtcc gccaggctcc agggaagggg ctggagtgga tcgggtccat      180

ttggagtggt ggtaccacag actacgcgag ctgggcgaaa agccgatcca ccataaccag      240

aaacaccaac gagaacacgg tgactctgaa agtgaccagt ctgacagccg cggacacggc      300

cacctatttc tgtgcgaggg ggggttatga ttatggttat gcctcgaaca tctggggccc      360

aggcaccctg gtcaccgtct cctcagggca acctaaggct ccatca                     406


<210> 89
<211> 404
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 89
ctctggctcc caggtgccag atgtgcctat gatatgaccc agactccagc ctctgtggag       60

gtagctgtgg gaggcacagt caccatcaag tgccaggcca gtgaaagcat tagcagctac      120

ttatcctggt atcagcagaa accagggcag cctcccaagc tcctgatcta cagggcttcc      180

actctggcat ctggggtccc atcgcggttc agtggcagtg gatctgggac agagttcact      240

ctcaccatca gcgacgggca gtgtgacgat gctgccactt actactgtca acagggttat      300

agtgttagta atgttgataa tattttcggc ggagggaccg aggtggtggt caaaggtgat      360

ccagttgcac ctactgtcct catcttccca ccatcagcgg acca                       404


<210> 90
<211> 459
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 90
cctggtcgct gtgctcaaag gtgtccagtg tcagtcggtg aaggagtccg agggaggtct       60

cttcaagcca acggatgccc tgacactcac ctgcacagtc tctggattct ccctcagtag      120

ctatgcaata agctgggtcc gccaggctcc agggagcggg ctggaatgga tcggagccat      180

taatacttat ggtggcacat actacgcgag ctgggcgaaa agccgatcca ccatcaccag      240

aaacaccaac gagaacacgg tgactctgaa aatgaccagt ctgacagccg cggacacggc      300

cacctatttc tgtgcgagag acttcgatag tgatgcttat acttctgcta gtgggggcat      360

ggacccctgg ggcccaggga ccctcgtcac cgtctcttca gggcaaccta aggctccatc      420

attcttccca ctggccccct gctgcgggga cacacccag                             459


<210> 91
<211> 400
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 91
tctggctccc aggtgccaga tgtgcctatg atatgaccca gactccagcc tctgtggagg       60

tagctgtggg aggcacagtc accatcaagt gccaggccag tcagagcatt aacaactact      120

tatcctggta tcagcaaata ccagggcagc ctcccaagct cctgatctac agggcatcca      180

ctctggcatc tggggtctca tcgcggttca aaggcagtgg atctgggaca cagttcactc      240

tcaccatcag cggcgtgcag tgtgccgatg ctgccactta ctactgtcaa cagggttata      300

ctagtaatgt tgataatgtt ttcggcggag ggaccgaggt ggtggtcaaa ggtgatccag      360

ttgcacctac tgtcctcatc ttcccaccat cagcggacca                            400


<210> 92
<211> 450
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 92
ggtcgctgtg ctcaaaggtg tccagtgtca gtcggtgaag gagtccgagg gaggtctctt       60

caagccaacg gataccctga cactcacctg cacagtctct ggattctccc tcagtagcta      120

tgcaataggc tgggtccgcc aggctccagg gaacgggctg gaatggatcg gaaccattgt      180

tactagtggt atcccatact acgcgaactg ggcgaaaagc cgatccacca tcaccagaaa      240

caccaacctg aacacggtga ctctgaaaat gaccagtctg acagccgcgg acacggccac      300

ctatttctgt gcgagaaatt tagatcctgc ttatagtacc actcggttgg atctctgggg      360

ccagggcacc ctggtcaccg tctcctcagg gcaacctaag gctccatcag tcttcccact      420

ggccccctgc tgcggggaca cacccagctc                                       450


<210> 93
<211> 394
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 93
tctggctccc aggtgccaga tgtgcctatg atatgaccca gactccagcc tccgtgtctg       60

aacctgtgag aggcacagtc accatcaagt gccaggccag tcagagcatt agcactgcat      120

tagcctggta tcagcagaaa ccagggcagc ctcccaagct cctgatctat gctgcatcct      180

atctggcctc tggggtccca tcgcggttca gcggcagtgg atctgggaca gagttcactc      240

tcaccatcag cgacctggag tgtgccgatg ctgccactta ctactgtcat cagggttata      300

gtgctagtaa tgttgataat actttcggcg gagggaccga ggggggggtc aaaggtgatc      360

cagttgcacc tactgtcctc atcttcccac catc                                  394


<210> 94
<211> 450
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 94
ggtcgctgtg ctcaaaggtg tccagtgtca gtcagtgaag gagtccgagg gaggtctctt       60

caagccaacg gataccctga cactcacctg cacagtctct ggattctccc tcagtagcta      120

tgcaataagt tgggtccgcc aggctccagg gaacgggctg gaatggatcg gagccattgg      180

taaaagtggt agcgcatact acgcgagctg ggcgaaaagc cgatccacca tcaccagaaa      240

caccaacctg aacacggtgt cgctgaaaat gaccagtctg acagccgcgg acacggccac      300

ctatttctgt gcgagatggg atagtgttgg ttggactgat gctcggttgg atctctgggg      360

ccagggcacc ctggtcaccg tctcctcagg gcaacctaag gctccatcag tcttcccact      420

ggccccctgc tgcggggaca cacccagctc                                       450


<210> 95
<211> 402
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 95
ctggctccca ggtgccagat gtgcctatga tatgacccag actccagcct ctgtggaggt       60

agctgtggga ggcacagtca ccatcaagtg ccaggccagt cagagcatta gcactgcatt      120

agcctggtat cagcagaaac cagggcagcg tcccaagctc ctgatctatg gtgcatcgaa      180

actggcatct ggggtctcat cgcggttcag tggcagtgga tctgggacag agttcactct      240

caccatcagc ggcgtggagt gtgccgatgc tgccacttac tactgtcaac agggttatga      300

aactagtaat gttgataatg ctttcggcgg agggaccgag gtggtggtca aaggtgatcc      360

agttgcacct actgtcctca tcttcccacc atcagcggac ca                         402


<210> 96
<211> 408
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 96
ctggtcgctg tgctcaaagg tgtccagtgt cagtcggtga aggagtccga gggaggtctc       60

ttcaagccaa cggataccct gacactcacc tgcacagtct ctggattctc cctcagtgcc      120

tatgcaataa gctgggtccg ccaggctcca gggaacgggc tggaatggat cggagccatt      180

aatagtggtg gtagcgcata ctacgcgaac tgggcgaaaa gccgatccac catcaccaga      240

aacaccaacc tgaacacggt gactctgaaa atgaccagtc tgacagccgc ggacacggcc      300

acctatttct gtgcgaggga agatatttat gattatggtg gtgcattcga tccctggggc      360

ccaggcaccc tggtcaccgt ctccacaggg caacctaagc tccatcat                   408


<210> 97
<211> 401
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 97
ctggctccca ggtgccagat gtgcctatga tatgacccag actccagcct ctgtggaggt       60

aactgtggga ggcacagtca ccatcaagtg ccaggccagt caaggcatta gtagttactt      120

atcctggtat cagcagaaac cagggcagcc tcccaagctc ctgatctatg ctgcgaccac      180

tctggtatct ggggtctcat cgcggttcaa aggcagtgga tctgggacac agttcactct      240

caccatcagc ggcgtggagt gtgccgatgc tgccacttac tactgtcagc aggattatac      300

tactagtaat gttgataata ctttcggcgg agggaccgag gtggtggtca aaggtgatcc      360

agttgcacct actgtcctca tcttcccacc atcagcggac c                          401


<210> 98
<211> 443
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 98
gtcgctgtgc tcaaaggtgt ccagtgtcag tcggtgaagg agtccgaggg aggtctcttc       60

aagccaacgg ataccctgac actcacctgc acagtctctg gattctccct cagcatctat      120

ggagtgagct gggtccgcca ggctccaggg aacgggctgg aatggatcgg aatcatttat      180

gctagtggta gcgcagacta cgcgagctgg gcgaaaagcc gatccaccat caccagaaac      240

accaacctga acacggtgac tctgaagatg accagtctga cagccgcgga cacggccacc      300

tatttctgtg cgagagagga cgatacttat ggttatacta gtagtatatg gggcccaggc      360

accctggtca ccgtctcctc agggcaacct aaggctccat cagtcttccc actggccccc      420

tgctgcgggg acacacccag ctc                                              443


<210> 99
<211> 391
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 99
tggctcccag gtgccagatg tgcctatgat atgacccaga ctccagcctc cgtgtctgca       60

gctgtgggag gcacagtcac catcaagtgc caggccagtc agagcattag tagctactta      120

aactggtatc agcagaaacc agggcagcct cccaagcgcc tgatctacag ggcatccact      180

ctggcatctg gggtctcatc gcggttcaaa ggcagtggat ctgggacaca gttcactctc      240

accatcagcg gcgtggagtg tgccgatgct gccacttact actgtcaaca ggattatagt      300

agtaataata ttgataatac tttcggcgga gggaccgagg tggtggtcaa aggtgatcca      360

gttgcaccta ctgtcctcat cttcccacca t                                     391


<210> 100
<211> 440
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 100
ctggtcgctg tgctcaaagg tgtccagtgt cagtcggtga aggagtccga gggaggtctc       60

ttcaagccaa cggataccct gacactcacc tgcacagtct ctggattctc cctcagtagc      120

tatccaataa gctgggtccg ccaggctcca gggaacgggc tggaatggat cggagacatt      180

tatgctagtg gtagtatatt gtacgcgagc tgggcgacag gccgatctac catcaccaga      240

aataccaacc tgaacacggt gactctgaaa atgaccagtc tgacagccgc ggacacggcc      300

acctatttct gtgcgagagt aagttatagt ggtggtaccg acatctgggg cccaggcacc      360

ctggtcaccg tctcctcagg gcaacctaag gctccatcag tcttcccact ggccccctgc      420

tgcggggaca cacccagctc                                                  440


<210> 101
<211> 394
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 101
tctggctccc aggtgccaga tgtgcctatg atatgaccca gactccagcc tctgtggagg       60

tagctgtggg aggcacagtc accatcaagt gccaggccag tgaggacatt gaaagctatt      120

tagcctggta tcagcagaaa ccagggcagc ctcccaagct cctgatctac agggcatcca      180

ctctgccatc tggggtccca tcgcggttca aaggcagtgg atctgggaca gagttcactc      240

tcaccatcag cgacctggag tgtgccgatg ctgccactta ctactgtcaa caggattata      300

gtagtagtaa tgttgataat actttcggcg gagggaccga ggtggtggtc aaaggtgatc      360

cagttgcacc tactgtcctc atcttcccac catc                                  394


<210> 102
<211> 444
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 102
ctggtcgctg tgctcaaagg tgtccagtgt cagtcggtga aggagtccga gggaggtctc       60

ttcaagccaa cggataccct gacactcacc tgcacagtct ctggattctc cctcagtagc      120

aatgtaataa gctgggtccg ccaggctcca gggaaggggc tggagtggat cggagacatt      180

tatgttagtg gtaacacaga ctacgcgagc tgggcgaaaa gccgatccac catcaccaga      240

aacgccaacc tgaacacggt gactctgaaa atgaccagtc tgacagccgc ggacacggcc      300

acctatttct gtgcgagata tgatatgagt agtgatgctt tcgatccctg gggcccaggc      360

accctggtca ccgtctcctc agggcaacct aaggctccat cagtcttccc actggccccc      420

tgctgcgggg acacacccag ctcc                                             444


<210> 103
<211> 401
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 103
tctctggctc ccaggtgcca gatgtgccta tgatatgacc cagactccag cctctgtgga       60

ggtagctgtg ggaggcacag tcaccatcaa gtgccaggcc agtcagaaca ttggtagcta      120

cttatcctgg tatcagcaca aaccagggca gcgtcccaga ctcctgatgt acagggcatc      180

cactctggca tctggggtct catcgcggtt caaaggcagt ggatctggga cagagttcac      240

tctcaccatc agcggtgtgc agtgtgacaa tgctgccact tactactgtc aacagggtta      300

tactaatagt ggtgttgata atactttcgg cggagggacc gaggtggtgg tcaaaggtga      360

tccagttgca cctactgtcc tcatcttccc accatcagcg g                          401


<210> 104
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 104
atgaaggtaa caggcatctt tcttctcagt gccttggccc tgttgagtct atctggtaac       60

actggagct                                                               69


<210> 105
<211> 237
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 105
atgaaggtaa caggcatctt tcttctcagt gccttggccc tgttgagtct atctggtaac       60

actggagctg actccctggg aagagaggcc aaatgttaca atgaacttaa tggatgcacc      120

aagatatatg accctgtctg tgggactgat ggaaatactt atcccaatga atgcgtgtta      180

tgttttgaaa atcggaaacg ccagacttct atcctcattc aaaaatctgg gccttgc         237


<210> 106
<211> 168
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 106
gactccctgg gaagagaggc caaatgttac aatgaactta atggatgcac caagatatat       60

gaccctgtct gtgggactga tggaaatact tatcccaatg aatgcgtgtt atgttttgaa      120

aatcggaaac gccagacttc tatcctcatt caaaaatctg ggccttgc                   168


<210> 107
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="A"

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="N"

<220>
<221> VARIANT
<222> (4)..(4)
<223> /replace="G" or "P" or "V"

<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="V"

<220>
<221> SITE
<222> (1)..(6)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 107
Ser Ser Tyr Ala Ile Ser 
1               5       


<210> 108
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(4)
<223> Any amino acid

<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="G" or "Y"

<220>
<221> MOD_RES
<222> (7)..(9)
<223> Any amino acid

<220>
<221> SITE
<222> (1)..(16)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 108
Xaa Ile Xaa Xaa Ser Gly Xaa Xaa Xaa Tyr Ala Ser Trp Ala Lys Ser 
1               5                   10                  15      


<210> 109
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (2)..(11)
<223> Any amino acid

<400> 109
Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210> 110
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (4)..(4)
<223> /replace="E"

<220>
<221> VARIANT
<222> (5)..(5)
<223> /replace="G" or "D" or "N"

<220>
<221> VARIANT
<222> (7)..(7)
<223> /replace="N" or "E" or "G"

<220>
<221> MOD_RES 
<222> (8)..(8)
<223> Any amino acid

<220>
<221> VARIANT
<222> (9)..(9)
<223> /replace="A"

<220>
<221> MOD_RES 
<222> (11)..(11)
<223> Any amino acid

<220>
<221> SITE
<222> (1)..(11)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 110
Gln Ala Ser Gln Ser Ile Ser Xaa Tyr Leu Xaa 
1               5                   10      


<210> 111
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES 
<222> (1)..(1)
<223> Any amino acid

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="T"

<220>
<221> VARIANT
<222> (4)..(4)
<223> /replace="Y" or "K"

<220>
<221> VARIANT
<222> (6)..(6)
<223> /replace="P" or "V"

<220>
<221> SITE
<222> (1)..(7)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 111
Xaa Ala Ser Thr Leu Ala Ser 
1               5           


<210> 112
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace="H"

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="D"

<220>
<221> MOD_RES 
<222> (5)..(6)
<223> Any amino acid

<220>
<221> VARIANT
<222> (7)..(7)
<223> /replace="N"

<220>
<221> VARIANT
<222> (8)..(8)
<223> /replace="D" or "V" or "G"

<220>
<221> VARIANT
<222> (9)..(9)
<223> /replace="D" or "I"

<220>
<221> VARIANT
<222> (10)..(10)
<223> /replace="G" or "N"

<220>
<221> VARIANT
<222> (11)..(11)
<223> /replace="V"

<220>
<221> MOD_RES
<222> (12)..(12)
<223> Any amino acid

<220>
<221> SITE
<222> (1)..(12)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 112
Gln Gln Gly Tyr Xaa Xaa Ser Asn Val Asp Asn Xaa 
1               5                   10          


<210> 113
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 113
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


